{"data_date":"2026-11-08","library_size":29380,"matched_against":"each record's title and abstract (summary field), case-insensitive","n":2002,"page":"https://alzhub.org/answers/blood-test-for-alzheimers","query":"title or abstract mentions \"blood test\", \"blood-based biomarker/test/assay\", \"plasma p-tau/biomarker/A\u03b2/amyloid/NfL/GFAP\", \"p-tau217/181/231\" or \"serum p-tau/biomarker/NfL/GFAP\"","studies":[{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-to-detect-alzheimer-disease-in-primary-care-and-e791e2c1","doi":null,"journal":"JAMA","n_participants":1213,"pmid":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/39068545/","study_design":"cross-sectional","title":"Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care","title_match":false,"year":2024},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/clinical-validation-of-the-precivityad2-blood-test-a-mass-1b1b5bc0","doi":null,"journal":"Alzheimer's & Dementia","n_participants":583,"pmid":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/38491912/","study_design":"cross-sectional","title":"Clinical validation of the PrecivityAD2 blood test: A mass spectrometry-based test with algorithm combining %p-tau217 and A\u03b242/40 ratio to identify presence of brain amyloid","title_match":true,"year":2024},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/independent-validation-of-the-precivityad2-blood-test-to-identify-7d747d82","doi":null,"journal":"npj Dementia","n_participants":191,"pmid":null,"source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12411272/","study_design":"cross-sectional","title":"Independent validation of the PrecivityAD2 blood test to identify presence or absence of brain amyloid pathology in individuals with cognitive impairment","title_match":true,"year":2025},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/diagnostic-accuracy-of-phosphorylated-tau217-in-detecting-alzheimer-s-519ae6e6","doi":null,"journal":"Alzheimer's & Dementia","n_participants":9787,"pmid":null,"source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11848338/","study_design":"meta-analysis","title":"Diagnostic accuracy of phosphorylated tau217 in detecting Alzheimer's disease pathology among cognitively impaired and unimpaired: A systematic review and meta-analysis","title_match":false,"year":2024},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/plasma-phospho-tau217-for-alzheimer-s-disease-diagnosis-in-primary-407e7d7f","doi":null,"journal":"Nature Medicine","n_participants":1767,"pmid":null,"source_url":"https://www.nature.com/articles/s41591-025-03622-w","study_design":"cross-sectional","title":"Plasma phospho-tau217 for Alzheimer's disease diagnosis in primary and secondary care using a fully automated platform","title_match":false,"year":2025},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/blood-phosphorylated-tau-for-the-diagnosis-of-alzheimer-s-disease-a-1f9fdc81","doi":null,"journal":"The Lancet Neurology","n_participants":29625,"pmid":null,"source_url":"https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00227-3/abstract","study_design":"meta-analysis","title":"Blood phosphorylated tau for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis","title_match":false,"year":2025},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-gfap-and-nfl-as-biomarkers-for-alzheimer-s-disease-c53cc9a6","doi":null,"journal":"Alzheimer's & Dementia","n_participants":1275,"pmid":null,"source_url":"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70987","study_design":"cohort","title":"Plasma P-tau217, GFAP, and NfL as biomarkers for Alzheimer's disease: role in disease stratification, pathological progression, and cognitive decline","title_match":true,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/pittsburgh-plasma-p-tau217-classification-accuracies-for-autosomal-e4bc0f72","doi":null,"journal":"Alzheimer's & Dementia","n_participants":363,"pmid":null,"source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12263344/","study_design":"cross-sectional","title":"Pittsburgh plasma p-tau217: Classification accuracies for autosomal dominant and sporadic Alzheimer's disease in the community","title_match":true,"year":2025},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/head-to-head-comparison-of-plasma-p-tau217-immunoassays-for-incipient-c113f7bd","doi":null,"journal":"Alzheimer's Research & Therapy","n_participants":344,"pmid":null,"source_url":"https://link.springer.com/article/10.1186/s13195-026-01969-x","study_design":"cross-sectional","title":"Head-to-head comparison of plasma p-tau217 immunoassays for incipient Alzheimer's disease in community cohorts","title_match":true,"year":2026},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/fda-approval-of-the-lumipulse-g-ptau217-amyloid-1-42-plasma-ratio-b441b009","doi":null,"journal":"Annals of Medicine and Surgery","n_participants":null,"pmid":null,"source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12889242/","study_design":null,"title":"FDA approval of the Lumipulse G pTau217/\u03b2-amyloid 1-42 plasma ratio test: a new era in accessible Alzheimer's diagnosis","title_match":true,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/nia-aa-research-framework-toward-a-biological-definition-of-alzheimer-75cea84d","doi":null,"journal":"Alzheimer's & Dementia","n_participants":null,"pmid":null,"source_url":"https://www.alzforum.org/papers/nia-aa-research-framework-toward-biological-definition-alzheimers-disease","study_design":null,"title":"NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/serum-neurofilament-dynamics-predicts-neurodegeneration-and-clinical-9106bc9f","doi":null,"journal":"Nature Medicine","n_participants":405,"pmid":null,"source_url":"https://pubmed.ncbi.nlm.nih.gov/30664784/","study_design":"cohort","title":"Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/plasma-glial-fibrillary-acidic-protein-detects-alzheimer-pathology-d7e9adeb","doi":null,"journal":"Alzheimer's Research & Therapy","n_participants":160,"pmid":null,"source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8005231/","study_design":"cohort","title":"Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive impairment","title_match":false,"year":2021},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/clinical-imaging-and-blood-biomarker-outcomes-in-a-phase-3-clinical-41570392","doi":"10.1016/j.tjpad.2026.100480","journal":"The Journal of Prevention of Alzheimer's Disease","n_participants":598,"pmid":"41570392","source_url":"https://pubmed.ncbi.nlm.nih.gov/41570392/","study_design":"phase-3-trial","title":"Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/diet-quality-and-dementia-risk-in-older-adults-with-alzheimer-42348207","doi":"10.1001/jamanetworkopen.2026.20254","journal":"JAMA Network Open","n_participants":1865,"pmid":"42348207","source_url":"https://pubmed.ncbi.nlm.nih.gov/42348207/","study_design":"cohort","title":"Diet Quality and Dementia Risk in Older Adults With Alzheimer Pathology","title_match":false,"year":2026},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/alzheimer-s-association-clinical-practice-guideline-on-the-use-of-40729527","doi":"10.1002/alz.70535","journal":"Alzheimer's & Dementia","n_participants":null,"pmid":"40729527","source_url":"https://pubmed.ncbi.nlm.nih.gov/40729527/","study_design":"systematic-review","title":"Alzheimer's Association Clinical Practice Guideline on the use of blood-based biomarkers in the diagnostic workup of suspected Alzheimer's disease within specialized care settings","title_match":true,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-for-detecting-alzheimer-s-disease-pathology-in-41193403","doi":"10.1002/alz.70828","journal":"Alzheimer's & Dementia","n_participants":null,"pmid":"41193403","source_url":"https://pubmed.ncbi.nlm.nih.gov/41193403/","study_design":"meta-analysis","title":"Blood-based biomarkers for detecting Alzheimer's disease pathology in cognitively impaired individuals within specialized care settings: A systematic review and meta-analysis","title_match":true,"year":2025},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-217-and-incident-mild-cognitive-impairment-41805953","doi":"10.1001/jamanetworkopen.2026.1295","journal":"JAMA Network Open","n_participants":2766,"pmid":"41805953","source_url":"https://pubmed.ncbi.nlm.nih.gov/41805953/","study_design":"cohort","title":"Plasma Phosphorylated Tau 217 and Incident Mild Cognitive Impairment and Dementia in Older Women","title_match":false,"year":2026},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-for-detecting-amyloid-clearance-after-donanemab-in-42565262","doi":"10.1002/alz.71740","journal":"Alzheimer's & Dementia","n_participants":830,"pmid":"42565262","source_url":"https://pubmed.ncbi.nlm.nih.gov/42565262/","study_design":"phase-3-trial","title":"Plasma P-tau217 for detecting amyloid clearance after donanemab in Alzheimer's disease","title_match":true,"year":2026},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/apoe-and-alzheimer-s-disease-and-related-dementias-risk-among-12-221-40219824","doi":"10.1002/alz.70138","journal":"Alzheimer's & Dementia","n_participants":12221,"pmid":"40219824","source_url":"https://pubmed.ncbi.nlm.nih.gov/40219824/","study_design":"case-control","title":"APOE and Alzheimer's disease and related dementias risk among 12,221 Hispanics/Latinos","title_match":false,"year":2025},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/predicting-onset-of-symptomatic-alzheimer-s-disease-with-plasma-p-41714746","doi":"10.1038/s41591-026-04206-y","journal":"Nature medicine","n_participants":603,"pmid":"41714746","source_url":"https://pubmed.ncbi.nlm.nih.gov/41714746/","study_design":"cohort","title":"Predicting onset of symptomatic Alzheimer's disease with plasma p-tau217 clocks","title_match":true,"year":2026},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/integration-of-plasma-emtbr-tau243-and-p-tau217-in-the-diagnosis-and-41864233","doi":"10.1016/S1474-4422(26)00029-3","journal":"The Lancet. Neurology","n_participants":572,"pmid":"41864233","source_url":"https://pubmed.ncbi.nlm.nih.gov/41864233/","study_design":"cohort","title":"Integration of plasma eMTBR-tau243 and p-tau217 in the diagnosis and stratification of Alzheimer's disease: a prospective cohort study","title_match":true,"year":2026},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-217-cutoffs-for-amyloid-pathology-and-41627837","doi":"10.1001/jamaneurol.2025.5530","journal":"JAMA neurology","n_participants":2571,"pmid":"41627837","source_url":"https://pubmed.ncbi.nlm.nih.gov/41627837/","study_design":"cross-sectional","title":"Plasma Phosphorylated Tau 217 Cutoffs for Amyloid Pathology and Kidney Function, Body Mass Index, and Anemia","title_match":false,"year":2026},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/prognostic-value-of-blood-based-p-tau217-levels-for-progression-to-42449500","doi":"10.1001/jama.2026.12556","journal":"JAMA","n_participants":2684,"pmid":"42449500","source_url":"https://pubmed.ncbi.nlm.nih.gov/42449500/","study_design":"cohort","title":"Prognostic Value of Blood-Based P-Tau217 Levels for Progression to Cognitive Impairment","title_match":true,"year":2026},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-217-concentrations-apoe-genotype-and-timing-42716078","doi":"10.1016/S1474-4422(26)00313-3","journal":"The Lancet. Neurology","n_participants":8582,"pmid":"42716078","source_url":"https://pubmed.ncbi.nlm.nih.gov/42716078/","study_design":"cohort","title":"Plasma phosphorylated tau 217 concentrations, APOE genotype, and timing of cognitive impairment in individuals across diverse racial and ethnic groups: a pooled analysis of prospective cohort studies","title_match":false,"year":2026},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/sex-differences-in-p-tau217-tau-aggregation-and-cognitive-decline-41697669","doi":"10.1001/jamaneurol.2025.5670","journal":"JAMA neurology","n_participants":1292,"pmid":"41697669","source_url":"https://pubmed.ncbi.nlm.nih.gov/41697669/","study_design":"cohort","title":"Sex Differences in P-Tau217, Tau Aggregation, and Cognitive Decline","title_match":true,"year":2026},{"alzhub_score":84,"alzhub_url":"https://alzhub.org/study/diagnostic-accuracy-of-a-plasma-phosphorylated-tau-217-immunoassay-38252443","doi":"10.1001/jamaneurol.2023.5319","journal":"JAMA Neurology","n_participants":786,"pmid":"38252443","source_url":"https://pubmed.ncbi.nlm.nih.gov/38252443/","study_design":"cohort","title":"Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology","title_match":false,"year":2024},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/a-two-step-workflow-based-on-plasma-p-tau217-to-screen-for-amyloid-37653254","doi":"10.1038/s43587-023-00471-5","journal":"Nature Aging","n_participants":348,"pmid":"37653254","source_url":"https://pubmed.ncbi.nlm.nih.gov/37653254/","study_design":"cohort","title":"A two-step workflow based on plasma p-tau217 to screen for amyloid \u03b2 positivity with further confirmatory testing only in uncertain cases","title_match":true,"year":2023},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/a-comprehensive-head-to-head-comparison-of-key-plasma-phosphorylated-39468767","doi":"10.1093/brain/awae346","journal":"Brain","n_participants":998,"pmid":"39468767","source_url":"https://pubmed.ncbi.nlm.nih.gov/39468767/","study_design":"cohort","title":"A comprehensive head-to-head comparison of key plasma phosphorylated tau 217 biomarker tests","title_match":false,"year":2025},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-217-and-a42-40-to-predict-early-brain-a-39068669","doi":"10.1001/jamaneurol.2024.2619","journal":"JAMA Neurology","n_participants":983,"pmid":"39068669","source_url":"https://pubmed.ncbi.nlm.nih.gov/39068669/","study_design":"cohort","title":"Plasma Phosphorylated Tau 217 and A\u03b242/40 to Predict Early Brain A\u03b2 Accumulation in People Without Cognitive Impairment","title_match":false,"year":2024},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/diagnostic-accuracy-of-plasma-p-tau217-a42-for-alzheimer-s-disease-in-40156286","doi":"10.1002/alz.70038","journal":"Alzheimer's & Dementia","n_participants":512,"pmid":"40156286","source_url":"https://pubmed.ncbi.nlm.nih.gov/40156286/","study_design":"cross-sectional","title":"Diagnostic accuracy of plasma p-tau217/A\u03b242 for Alzheimer's disease in clinical and community cohorts","title_match":true,"year":2025},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-and-tau-pet-predict-future-cognitive-decline-among-40155777","doi":"10.1038/s43587-025-00835-z","journal":"Nature Aging","n_participants":1474,"pmid":"40155777","source_url":"https://pubmed.ncbi.nlm.nih.gov/40155777/","study_design":"cohort","title":"Plasma p-tau217 and tau-PET predict future cognitive decline among cognitively unimpaired individuals: implications for clinical trials","title_match":true,"year":2025},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-217-to-identify-preclinical-alzheimer-40952756","doi":"10.1001/jamaneurol.2025.3217","journal":"JAMA Neurology","n_participants":2916,"pmid":"40952756","source_url":"https://pubmed.ncbi.nlm.nih.gov/40952756/","study_design":"cross-sectional","title":"Plasma Phosphorylated Tau 217 to Identify Preclinical Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-identifies-cognitively-normal-older-adults-who-will-40008832","doi":"10.1002/alz.14537","journal":"Alzheimer's & Dementia","n_participants":215,"pmid":"40008832","source_url":"https://pubmed.ncbi.nlm.nih.gov/40008832/","study_design":"cohort","title":"Plasma p-tau217 identifies cognitively normal older adults who will develop cognitive impairment in a 10-year window","title_match":true,"year":2025},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/concurrent-changes-in-plasma-phosphorylated-tau-217-tau-pet-and-40853684","doi":"10.1001/jamaneurol.2025.2974","journal":"JAMA Neurology","n_participants":1707,"pmid":"40853684","source_url":"https://pubmed.ncbi.nlm.nih.gov/40853684/","study_design":"cohort","title":"Concurrent Changes in Plasma Phosphorylated Tau 217, Tau PET, and Cognition in Preclinical Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/comparison-of-plasma-p-tau217-a42-p-tau217-and-a42-a40-biomarkers-by-40801297","doi":"10.1002/alz.70469","journal":"Alzheimer's & Dementia","n_participants":1135,"pmid":"40801297","source_url":"https://pubmed.ncbi.nlm.nih.gov/40801297/","study_design":"cross-sectional","title":"Comparison of plasma p-tau217/A\u03b242, p-tau217, and A\u03b242/A\u03b240 biomarkers by race to detect Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/quantitative-assessment-of-the-effect-of-chronic-kidney-disease-on-39823562","doi":"10.1212/WNL.0000000000210287","journal":"Neurology","n_participants":202,"pmid":"39823562","source_url":"https://pubmed.ncbi.nlm.nih.gov/39823562/","study_design":"cross-sectional","title":"Quantitative Assessment of the Effect of Chronic Kidney Disease on Plasma P-Tau217 Concentrations","title_match":true,"year":2025},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/changes-in-alzheimer-disease-blood-biomarkers-and-associations-with-39068543","doi":"10.1001/jama.2024.6619","journal":"JAMA","n_participants":1525,"pmid":"39068543","source_url":"https://pubmed.ncbi.nlm.nih.gov/39068543/","study_design":"cohort","title":"Changes in Alzheimer Disease Blood Biomarkers and Associations With Incident All-Cause Dementia","title_match":false,"year":2024},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/plasma-biomarker-strategy-for-selecting-patients-with-alzheimer-38048096","doi":"10.1001/jamaneurol.2023.4596","journal":"JAMA Neurology","n_participants":912,"pmid":"38048096","source_url":"https://pubmed.ncbi.nlm.nih.gov/38048096/","study_design":"cohort","title":"Plasma Biomarker Strategy for Selecting Patients With Alzheimer Disease for Antiamyloid Immunotherapies","title_match":true,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-alzheimer-biomarkers-and-diagnostic-decision-making-in-memory-42593792","doi":"10.1001/jamanetworkopen.2026.28864","journal":"JAMA Network Open","n_participants":450,"pmid":"42593792","source_url":"https://pubmed.ncbi.nlm.nih.gov/42593792/","study_design":"cohort","title":"Plasma Alzheimer Biomarkers and Diagnostic Decision-Making in Memory Clinics","title_match":false,"year":2026},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/prognostic-value-of-plasma-glial-fibrillary-acidic-protein-in-41268784","doi":"10.1002/alz.70948","journal":"Alzheimer's & Dementia","n_participants":949,"pmid":"41268784","source_url":"https://pubmed.ncbi.nlm.nih.gov/41268784/","study_design":"cohort","title":"Prognostic value of plasma glial fibrillary acidic protein in cognitively unimpaired older adults: Results from the A4 study","title_match":false,"year":2025},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/serum-gfap-levels-correlate-with-astrocyte-reactivity-post-mortem-38634687","doi":"10.1093/brain/awae035","journal":"Brain","n_participants":139,"pmid":"38634687","source_url":"https://pubmed.ncbi.nlm.nih.gov/38634687/","study_design":"cohort","title":"Serum GFAP levels correlate with astrocyte reactivity, post-mortem brain atrophy and neurofibrillary tangles","title_match":true,"year":2024},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/serum-nfl-and-gfap-are-associated-with-incident-dementia-and-dementia-37392405","doi":"10.1002/alz.13367","journal":"Alzheimer's & Dementia","n_participants":1712,"pmid":"37392405","source_url":"https://pubmed.ncbi.nlm.nih.gov/37392405/","study_design":"cohort","title":"Serum NfL and GFAP are associated with incident dementia and dementia mortality in older adults: The cardiovascular health study","title_match":true,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/diagnostic-performance-of-plasma-a42-40-ratio-p-tau181-gfap-and-nfl-40551285","doi":"10.1002/alz.14573","journal":"Alzheimer's & Dementia","n_participants":1298,"pmid":"40551285","source_url":"https://pubmed.ncbi.nlm.nih.gov/40551285/","study_design":"cross-sectional","title":"Diagnostic performance of plasma A\u03b242/40 ratio, p-tau181, GFAP, and NfL along the continuum of Alzheimer's disease and non-AD dementias: An international multi-center study","title_match":true,"year":2025},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/diagnostic-performance-of-plasma-p-tau217-and-a42-40-biomarkers-in-40476540","doi":"10.1002/alz.70316","journal":"Alzheimer's & Dementia","n_participants":509,"pmid":"40476540","source_url":"https://pubmed.ncbi.nlm.nih.gov/40476540/","study_design":"cross-sectional","title":"Diagnostic performance of plasma p-tau217 and A\u03b242/40 biomarkers in the outpatient memory clinic","title_match":true,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/estimation-of-the-value-based-price-of-a-blood-test-for-alzheimer-s-40494736","doi":"10.1016/j.tjpad.2025.100219","journal":"Journal of Prevention of Alzheimer's Disease","n_participants":null,"pmid":"40494736","source_url":"https://pubmed.ncbi.nlm.nih.gov/40494736/","study_design":"modelling","title":"Estimation of the value-based price of a blood test for Alzheimer's disease pathology in primary and specialty care in the U.S","title_match":true,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/microglia-modulate-a-dependent-astrocyte-reactivity-in-alzheimer-s-41198899","doi":"10.1038/s41593-025-02103-0","journal":"Nature Neuroscience","n_participants":352,"pmid":"41198899","source_url":"https://pubmed.ncbi.nlm.nih.gov/41198899/","study_design":"cohort","title":"Microglia modulate A\u03b2-dependent astrocyte reactivity in Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/interplay-between-astrocyte-reactivity-and-apoe-4-status-is-41163175","doi":"10.1186/s13024-025-00906-0","journal":"Molecular Neurodegeneration","n_participants":806,"pmid":"41163175","source_url":"https://pubmed.ncbi.nlm.nih.gov/41163175/","study_design":"cohort","title":"Interplay between astrocyte reactivity and APOE \u03b54 status is associated with accelerated pTau-related tau pathology in Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/apoe4-lowers-the-ptau217-threshold-for-tau-aggregation-and-spread-in-41410687","doi":"10.1093/brain/awaf463","journal":"Brain","n_participants":401,"pmid":"41410687","source_url":"https://pubmed.ncbi.nlm.nih.gov/41410687/","study_design":"cohort","title":"ApoE4 lowers the ptau217 threshold for tau aggregation and spread in an allele dose-dependent manner","title_match":true,"year":2026},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/plasma-emtbr-tau243-and-p-tau217-for-biological-staging-of-alzheimer-42189519","doi":"10.1001/jamaneurol.2026.1405","journal":"JAMA Neurology","n_participants":1028,"pmid":"42189519","source_url":"https://pubmed.ncbi.nlm.nih.gov/42189519/","study_design":"cohort","title":"Plasma eMTBR-tau243 and %p-tau217 for Biological Staging of Alzheimer Disease","title_match":true,"year":2026},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/assessing-cognitive-decline-and-dementia-risk-in-black-and-white-41151002","doi":"10.1212/WNL.0000000000214317","journal":"Neurology","n_participants":1014,"pmid":"41151002","source_url":"https://pubmed.ncbi.nlm.nih.gov/41151002/","study_design":"cohort","title":"Assessing Cognitive Decline and Dementia Risk in Black and White Older Adults With Blood Biomarkers pTau217, GFAP, NfL, and A\u03b2 Ratio","title_match":true,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/blood-based-at-n-biomarkers-for-alzheimer-s-disease-and-41688826","doi":"10.1038/s43587-025-01061-3","journal":"Nature Aging","n_participants":605,"pmid":"41688826","source_url":"https://pubmed.ncbi.nlm.nih.gov/41688826/","study_design":"cross-sectional","title":"Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America","title_match":false,"year":2026},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/electronic-health-records-to-test-multimorbidity-influences-to-plasma-41447112","doi":"10.1002/ana.78114","journal":"Annals of neurology","n_participants":617,"pmid":"41447112","source_url":"https://pubmed.ncbi.nlm.nih.gov/41447112/","study_design":"cross-sectional","title":"Electronic Health Records to Test Multimorbidity Influences to Plasma Biomarker Interpretation for Alzheimer's Disease","title_match":true,"year":2026},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/study-of-the-utility-and-impact-of-a-plasma-p-tau181-alzheimer-s-42254757","doi":"10.1002/trc2.70207","journal":"Alzheimer's & Dementia: Translational Research & Clinical Interventions","n_participants":100,"pmid":"42254757","source_url":"https://pubmed.ncbi.nlm.nih.gov/42254757/","study_design":"cohort","title":"Study of the utility and impact of a plasma p-tau181 Alzheimer's biomarker (SUITABLE)","title_match":true,"year":2026},{"alzhub_score":81,"alzhub_url":"https://alzhub.org/study/csf-and-blood-biomarkers-for-the-diagnosis-of-alzheimer-s-disease-a-27068280","doi":"10.1016/s1474-4422(16)00070-3","journal":"The Lancet. Neurology","n_participants":699,"pmid":"27068280","source_url":"https://pubmed.ncbi.nlm.nih.gov/27068280/","study_design":"systematic review","title":"CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis","title_match":false,"year":2016},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/discriminative-accuracy-of-plasma-phospho-tau217-for-alzheimer-32722745","doi":"10.1001/jama.2020.12134","journal":"JAMA","n_participants":301,"pmid":"32722745","source_url":"https://pubmed.ncbi.nlm.nih.gov/32722745/","study_design":"cross-sectional","title":"Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders","title_match":false,"year":2020},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/association-of-plasma-neurofilament-light-with-neurodegeneration-in-28346578","doi":"10.1001/jamaneurol.2016.6117","journal":"JAMA neurology","n_participants":197,"pmid":"28346578","source_url":"https://pubmed.ncbi.nlm.nih.gov/28346578/","study_design":"case-control study","title":"Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease","title_match":false,"year":2017},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/high-precision-plasma-amyloid-42-40-predicts-current-and-future-brain-31371569","doi":"10.1212/wnl.0000000000008081","journal":"Neurology","n_participants":null,"pmid":"31371569","source_url":"https://pubmed.ncbi.nlm.nih.gov/31371569/","study_design":null,"title":"High-precision plasma \u03b2-amyloid 42/40 predicts current and future brain amyloidosis","title_match":false,"year":2019},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/serum-neurofilament-dynamics-predicts-neurodegeneration-and-clinical-30664784","doi":"10.1038/s41591-018-0304-3","journal":"Nature medicine","n_participants":187,"pmid":"30664784","source_url":"https://pubmed.ncbi.nlm.nih.gov/30664784/","study_design":"cross-sectional","title":"Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/association-between-longitudinal-plasma-neurofilament-light-and-31009028","doi":"10.1001/jamaneurol.2019.0765","journal":"JAMA neurology","n_participants":1583,"pmid":"31009028","source_url":"https://pubmed.ncbi.nlm.nih.gov/31009028/","study_design":"cohort study","title":"Association Between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients With Alzheimer Disease","title_match":false,"year":2019},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/differences-between-plasma-and-cerebrospinal-fluid-glial-fibrillary-34661615","doi":"10.1001/jamaneurol.2021.3671","journal":"JAMA neurology","n_participants":300,"pmid":"34661615","source_url":"https://pubmed.ncbi.nlm.nih.gov/34661615/","study_design":"cross-sectional","title":"Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum","title_match":false,"year":2021},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/highly-accurate-blood-test-for-alzheimer-s-disease-is-similar-or-38382645","doi":"10.1038/s41591-024-02869-z","journal":"Nature medicine","n_participants":1422,"pmid":"38382645","source_url":"https://pubmed.ncbi.nlm.nih.gov/38382645/","study_design":null,"title":"Highly accurate blood test for Alzheimer's disease is similar or superior to clinical cerebrospinal fluid tests","title_match":true,"year":2024},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/associations-of-plasma-phospho-tau217-levels-with-tau-positron-33165506","doi":"10.1001/jamaneurol.2020.4201","journal":"JAMA neurology","n_participants":225,"pmid":"33165506","source_url":"https://pubmed.ncbi.nlm.nih.gov/33165506/","study_design":"cohort study","title":"Associations of Plasma Phospho-Tau217 Levels With Tau Positron Emission Tomography in Early Alzheimer Disease","title_match":false,"year":2021},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-to-detect-alzheimer-disease-in-primary-care-and-39068545","doi":"10.1001/jama.2024.13855","journal":"JAMA","n_participants":307,"pmid":"39068545","source_url":"https://pubmed.ncbi.nlm.nih.gov/39068545/","study_design":null,"title":"Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care","title_match":false,"year":2024},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/prediction-of-longitudinal-cognitive-decline-in-preclinical-alzheimer-36745413","doi":"10.1001/jamaneurol.2022.5272","journal":"JAMA neurology","n_participants":564,"pmid":"36745413","source_url":"https://pubmed.ncbi.nlm.nih.gov/36745413/","study_design":"cohort study","title":"Prediction of Longitudinal Cognitive Decline in Preclinical Alzheimer Disease Using Plasma Biomarkers","title_match":true,"year":2023},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/plasma-glial-fibrillary-acidic-protein-detects-alzheimer-pathology-33773595","doi":"10.1186/s13195-021-00804-9","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"33773595","source_url":"https://pubmed.ncbi.nlm.nih.gov/33773595/","study_design":"longitudinal study","title":"Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive impairment","title_match":false,"year":2021},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/longitudinal-associations-of-blood-phosphorylated-tau181-and-33427873","doi":"10.1001/jamaneurol.2020.4986","journal":"JAMA neurology","n_participants":1113,"pmid":"33427873","source_url":"https://pubmed.ncbi.nlm.nih.gov/33427873/","study_design":"cohort study","title":"Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer Disease","title_match":false,"year":2021},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/association-of-phosphorylated-tau-biomarkers-with-amyloid-positron-36508198","doi":"10.1001/jamaneurol.2022.4485","journal":"JAMA neurology","n_participants":609,"pmid":"36508198","source_url":"https://pubmed.ncbi.nlm.nih.gov/36508198/","study_design":"cross-sectional","title":"Association of Phosphorylated Tau Biomarkers With Amyloid Positron Emission Tomography vs Tau Positron Emission Tomography","title_match":false,"year":2023},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/csf-mtbr-tau243-is-a-specific-biomarker-of-tau-tangle-pathology-in-37443334","doi":"10.1038/s41591-023-02443-z","journal":"Nature medicine","n_participants":448,"pmid":"37443334","source_url":"https://pubmed.ncbi.nlm.nih.gov/37443334/","study_design":null,"title":"CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":82,"alzhub_url":"https://alzhub.org/study/association-of-donanemab-treatment-with-exploratory-plasma-biomarkers-36251300","doi":"10.1001/jamaneurol.2022.3392","journal":"JAMA neurology","n_participants":1955,"pmid":"36251300","source_url":"https://pubmed.ncbi.nlm.nih.gov/36251300/","study_design":null,"title":"Association of Donanemab Treatment With Exploratory Plasma Biomarkers in Early Symptomatic Alzheimer Disease: A Secondary Analysis of the TRAILBLAZER-ALZ Randomized Clinical Trial","title_match":true,"year":2022},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/comparison-of-plasma-phosphorylated-tau-species-with-amyloid-and-tau-34309632","doi":"10.1001/jamaneurol.2021.2293","journal":"JAMA neurology","n_participants":1329,"pmid":"34309632","source_url":"https://pubmed.ncbi.nlm.nih.gov/34309632/","study_design":null,"title":"Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive Outcomes","title_match":false,"year":2021},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/serum-neurofilament-light-in-familial-alzheimer-disease-a-marker-of-29070659","doi":"10.1212/wnl.0000000000004667","journal":"Neurology","n_participants":48,"pmid":"29070659","source_url":"https://pubmed.ncbi.nlm.nih.gov/29070659/","study_design":"cross-sectional","title":"Serum neurofilament light in familial Alzheimer disease: A marker of early neurodegeneration","title_match":false,"year":2017},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/levels-of-plasma-neurofilament-light-chain-and-cognitive-function-in-30478269","doi":"10.1038/s41598-018-35766-w","journal":"Scientific reports","n_participants":null,"pmid":"30478269","source_url":"https://pubmed.ncbi.nlm.nih.gov/30478269/","study_design":null,"title":"Levels of plasma neurofilament light chain and cognitive function in patients with Alzheimer or Parkinson disease","title_match":false,"year":2018},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/validation-of-plasma-amyloid-42-40-for-detecting-alzheimer-disease-34906975","doi":"10.1212/wnl.0000000000013211","journal":"Neurology","n_participants":465,"pmid":"34906975","source_url":"https://pubmed.ncbi.nlm.nih.gov/34906975/","study_design":null,"title":"Validation of Plasma Amyloid-\u03b2 42/40 for Detecting Alzheimer Disease Amyloid Plaques","title_match":true,"year":2022},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/quantification-of-plasma-phosphorylated-tau-to-use-as-a-biomarker-for-28866979","doi":"10.1186/s13024-017-0206-8","journal":"Molecular neurodegeneration","n_participants":20,"pmid":"28866979","source_url":"https://pubmed.ncbi.nlm.nih.gov/28866979/","study_design":null,"title":"Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer's disease and down syndrome","title_match":false,"year":2017},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/plasma-and-csf-biomarkers-for-the-diagnosis-of-alzheimer-s-disease-in-30172624","doi":"10.1016/s1474-4422(18)30285-0","journal":"The Lancet. Neurology","n_participants":282,"pmid":"30172624","source_url":"https://pubmed.ncbi.nlm.nih.gov/30172624/","study_design":"cross-sectional","title":"Plasma and CSF biomarkers for the diagnosis of Alzheimer's disease in adults with Down syndrome: a cross-sectional study","title_match":false,"year":2018},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-associated-with-the-apolipoprotein-e-genotype-and-22801723","doi":"10.1001/archneurol.2012.1070","journal":"Archives of neurology","n_participants":null,"pmid":"22801723","source_url":"https://pubmed.ncbi.nlm.nih.gov/22801723/","study_design":"cohort study","title":"Plasma biomarkers associated with the apolipoprotein E genotype and Alzheimer disease","title_match":true,"year":2012},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/diagnostic-value-of-plasma-p-tau181-nfl-and-gfap-in-a-clinical-36221099","doi":"10.1186/s13195-022-01093-6","journal":"Alzheimer's research & therapy","n_participants":59,"pmid":"36221099","source_url":"https://pubmed.ncbi.nlm.nih.gov/36221099/","study_design":null,"title":"Diagnostic value of plasma p-tau181, NfL, and GFAP in a clinical setting cohort of prevalent neurodegenerative dementias","title_match":true,"year":2022},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/serum-markers-glial-fibrillary-acidic-protein-and-neurofilament-light-36098162","doi":"10.1016/s2666-7568(20)30061-1","journal":"The lancet. Healthy longevity","n_participants":300,"pmid":"36098162","source_url":"https://pubmed.ncbi.nlm.nih.gov/36098162/","study_design":"cohort study","title":"Serum markers glial fibrillary acidic protein and neurofilament light for prognosis and monitoring in cognitively normal older people: a prospective memory clinic-based cohort study","title_match":false,"year":2021},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/assessment-of-plasma-total-tau-level-as-a-predictive-biomarker-for-30830207","doi":"10.1001/jamaneurol.2018.4666","journal":"JAMA neurology","n_participants":1453,"pmid":"30830207","source_url":"https://pubmed.ncbi.nlm.nih.gov/30830207/","study_design":"cohort study","title":"Assessment of Plasma Total Tau Level as a Predictive Biomarker for Dementia and Related Endophenotypes","title_match":false,"year":2019},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/mitigating-the-associations-of-kidney-dysfunction-with-blood-36987840","doi":"10.1001/jamaneurol.2023.0199","journal":"JAMA neurology","n_participants":141,"pmid":"36987840","source_url":"https://pubmed.ncbi.nlm.nih.gov/36987840/","study_design":"cross-sectional","title":"Mitigating the Associations of Kidney Dysfunction With Blood Biomarkers of Alzheimer Disease by Using Phosphorylated Tau to Total Tau Ratios","title_match":false,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/an-update-on-blood-based-biomarkers-for-non-alzheimer-32322100","doi":"10.1038/s41582-020-0348-0","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"32322100","source_url":"https://pubmed.ncbi.nlm.nih.gov/32322100/","study_design":null,"title":"An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders","title_match":true,"year":2020},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/diagnostic-performance-of-plasma-ptau-sub-217-sub-ptau-sub-181-sub-a-38926773","doi":"10.1186/s13195-024-01513-9","journal":"Alzheimer's research & therapy","n_participants":130,"pmid":"38926773","source_url":"https://pubmed.ncbi.nlm.nih.gov/38926773/","study_design":null,"title":"Diagnostic performance of plasma pTau217, pTau181, A\u03b21-42 and A\u03b21-40 in the LUMIPULSE automated platform for the detection of Alzheimer disease","title_match":true,"year":2024},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/remote-blood-biomarkers-of-longitudinal-cognitive-outcomes-in-a-32799383","doi":"10.1002/ana.25874","journal":"Annals of neurology","n_participants":1327,"pmid":"32799383","source_url":"https://pubmed.ncbi.nlm.nih.gov/32799383/","study_design":"longitudinal study","title":"Remote Blood Biomarkers of Longitudinal Cognitive Outcomes in a Population Study","title_match":false,"year":2020},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/plasma-tau-and-neurofilament-light-in-frontotemporal-lobar-33199433","doi":"10.1212/wnl.0000000000011226","journal":"Neurology","n_participants":265,"pmid":"33199433","source_url":"https://pubmed.ncbi.nlm.nih.gov/33199433/","study_design":"cross-sectional","title":"Plasma Tau and Neurofilament Light in Frontotemporal Lobar Degeneration and Alzheimer Disease","title_match":false,"year":2021},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-in-the-presenilin-1-e280a-autosomal-32470423","doi":"10.1016/s1474-4422(20)30137-x","journal":"The Lancet. Neurology","n_participants":null,"pmid":"32470423","source_url":"https://pubmed.ncbi.nlm.nih.gov/32470423/","study_design":"cohort study","title":"Plasma neurofilament light chain in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional and longitudinal cohort study","title_match":false,"year":2020},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/assessment-of-a-plasma-amyloid-probability-score-to-estimate-amyloid-35446396","doi":"10.1001/jamanetworkopen.2022.8392","journal":"JAMA network open","n_participants":249,"pmid":"35446396","source_url":"https://pubmed.ncbi.nlm.nih.gov/35446396/","study_design":"cohort study","title":"Assessment of a Plasma Amyloid Probability Score to Estimate Amyloid Positron Emission Tomography Findings Among Adults With Cognitive Impairment","title_match":true,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/astrocyte-biomarkers-gfap-and-ykl-40-mediate-early-alzheimer-s-37690071","doi":"10.1002/alz.13450","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37690071","source_url":"https://pubmed.ncbi.nlm.nih.gov/37690071/","study_design":null,"title":"Astrocyte biomarkers GFAP and YKL-40 mediate early Alzheimer's disease progression","title_match":false,"year":2024},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/comparing-the-clinical-utility-and-diagnostic-performance-of-csf-p-34493616","doi":"10.1212/wnl.0000000000012727","journal":"Neurology","n_participants":334,"pmid":"34493616","source_url":"https://pubmed.ncbi.nlm.nih.gov/34493616/","study_design":null,"title":"Comparing the Clinical Utility and Diagnostic Performance of CSF P-Tau181, P-Tau217, and P-Tau231 Assays","title_match":true,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/brain-imaging-and-blood-biomarker-abnormalities-in-children-with-26121081","doi":"10.1001/jamaneurol.2015.1099","journal":"JAMA neurology","n_participants":null,"pmid":"26121081","source_url":"https://pubmed.ncbi.nlm.nih.gov/26121081/","study_design":"cross-sectional","title":"Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease: A Cross-Sectional Study","title_match":false,"year":2015},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/amyloid-and-tau-prediction-of-cognitive-and-functional-decline-in-39044488","doi":"10.14283/jpad.2024.122","journal":"The journal of prevention of Alzheimer's disease","n_participants":583,"pmid":"39044488","source_url":"https://pubmed.ncbi.nlm.nih.gov/39044488/","study_design":"longitudinal study","title":"Amyloid and Tau Prediction of Cognitive and Functional Decline in Unimpaired Older Individuals: Longitudinal Data from the A4 and LEARN Studies","title_match":false,"year":2024},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/serum-neurofilament-light-chain-in-behavioral-variant-frontotemporal-30209235","doi":"10.1212/wnl.0000000000006318","journal":"Neurology","n_participants":74,"pmid":"30209235","source_url":"https://pubmed.ncbi.nlm.nih.gov/30209235/","study_design":null,"title":"Serum neurofilament light chain in behavioral variant frontotemporal dementia","title_match":false,"year":2018},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/csf-neurofilament-light-chain-and-phosphorylated-tau-181-predict-29282336","doi":"10.1212/wnl.0000000000004859","journal":"Neurology","n_participants":50,"pmid":"29282336","source_url":"https://pubmed.ncbi.nlm.nih.gov/29282336/","study_design":null,"title":"CSF neurofilament light chain and phosphorylated tau 181 predict disease progression in PSP","title_match":false,"year":2018},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/association-of-plasma-biomarkers-of-alzheimer-disease-with-cognition-37580163","doi":"10.1212/wnl.0000000000207675","journal":"Neurology","n_participants":267,"pmid":"37580163","source_url":"https://pubmed.ncbi.nlm.nih.gov/37580163/","study_design":null,"title":"Association of Plasma Biomarkers of Alzheimer Disease With Cognition and Medical Comorbidities in a Biracial Cohort","title_match":true,"year":2023},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/association-of-kidney-function-with-development-of-alzheimer-disease-36692879","doi":"10.1001/jamanetworkopen.2022.52387","journal":"JAMA network open","n_participants":766,"pmid":"36692879","source_url":"https://pubmed.ncbi.nlm.nih.gov/36692879/","study_design":"cohort study","title":"Association of Kidney Function With Development of Alzheimer Disease and Other Dementias and Dementia-Related Blood Biomarkers","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-in-neurodegenerative-diseases-implications-for-the-36878698","doi":"10.1212/wnl.0000000000207193","journal":"Neurology","n_participants":null,"pmid":"36878698","source_url":"https://pubmed.ncbi.nlm.nih.gov/36878698/","study_design":null,"title":"Blood Biomarkers in Neurodegenerative Diseases: Implications for the Clinical Neurologist","title_match":false,"year":2023},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/associations-of-fully-automated-csf-and-novel-plasma-biomarkers-with-34266917","doi":"10.1212/wnl.0000000000012513","journal":"Neurology","n_participants":27,"pmid":"34266917","source_url":"https://pubmed.ncbi.nlm.nih.gov/34266917/","study_design":null,"title":"Associations of Fully Automated CSF and Novel Plasma Biomarkers With Alzheimer Disease Neuropathology at Autopsy","title_match":true,"year":2021},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/timing-of-biomarker-changes-in-sporadic-alzheimer-s-disease-in-38400792","doi":"10.1002/ana.26891","journal":"Annals of neurology","n_participants":118,"pmid":"38400792","source_url":"https://pubmed.ncbi.nlm.nih.gov/38400792/","study_design":"cross-sectional","title":"Timing of Biomarker Changes in Sporadic Alzheimer's Disease in Estimated Years from Symptom Onset","title_match":false,"year":2024},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/association-of-plasma-and-cerebrospinal-fluid-alzheimer-disease-36201209","doi":"10.1001/jamanetworkopen.2022.35068","journal":"JAMA network open","n_participants":617,"pmid":"36201209","source_url":"https://pubmed.ncbi.nlm.nih.gov/36201209/","study_design":"cross-sectional","title":"Association of Plasma and Cerebrospinal Fluid Alzheimer Disease Biomarkers With Race and the Role of Genetic Ancestry, Vascular Comorbidities, and Neighborhood Factors","title_match":false,"year":2022},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/plasma-glial-fibrillary-acidic-protein-in-the-alzheimer-disease-36861369","doi":"10.1093/clinchem/hvad018","journal":"Clinical chemistry","n_participants":818,"pmid":"36861369","source_url":"https://pubmed.ncbi.nlm.nih.gov/36861369/","study_design":null,"title":"Plasma Glial Fibrillary Acidic Protein in the Alzheimer Disease Continuum: Relationship to Other Biomarkers, Differential Diagnosis, and Prediction of Clinical Progression","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/plasma-and-cerebrospinal-fluid-tau-and-neurofilament-concentrations-28816001","doi":"10.1111/ene.13389","journal":"European journal of neurology","n_participants":132,"pmid":"28816001","source_url":"https://pubmed.ncbi.nlm.nih.gov/28816001/","study_design":null,"title":"Plasma and cerebrospinal fluid tau and neurofilament concentrations in rapidly progressive neurological syndromes: a neuropathology-based cohort","title_match":false,"year":2017},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/alzheimer-blood-biomarkers-practical-guidelines-for-study-design-38750570","doi":"10.1186/s13024-024-00711-1","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"38750570","source_url":"https://pubmed.ncbi.nlm.nih.gov/38750570/","study_design":null,"title":"Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting","title_match":false,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/association-of-plasma-neurofilament-light-with-small-vessel-disease-33517704","doi":"10.1161/strokeaha.120.030302","journal":"Stroke","n_participants":496,"pmid":"33517704","source_url":"https://pubmed.ncbi.nlm.nih.gov/33517704/","study_design":"cross-sectional","title":"Association of Plasma Neurofilament Light With Small Vessel Disease Burden in Nondemented Elderly: A Longitudinal Study","title_match":false,"year":2021},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/association-of-chronic-kidney-disease-with-plasma-nfl-and-other-37225431","doi":"10.1212/wnl.0000000000207419","journal":"Neurology","n_participants":744,"pmid":"37225431","source_url":"https://pubmed.ncbi.nlm.nih.gov/37225431/","study_design":"cohort study","title":"Association of Chronic Kidney Disease With Plasma NfL and Other Biomarkers of Neurodegeneration: The H70 Birth Cohort Study in Gothenburg","title_match":true,"year":2023},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/detection-of-brain-tau-pathology-in-down-syndrome-using-plasma-35789365","doi":"10.1001/jamaneurol.2022.1740","journal":"JAMA neurology","n_participants":300,"pmid":"35789365","source_url":"https://pubmed.ncbi.nlm.nih.gov/35789365/","study_design":"cross-sectional","title":"Detection of Brain Tau Pathology in Down Syndrome Using Plasma Biomarkers","title_match":true,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/diagnostic-performance-and-clinical-applicability-of-blood-based-36450604","doi":"10.1212/wnl.0000000000201597","journal":"Neurology","n_participants":268,"pmid":"36450604","source_url":"https://pubmed.ncbi.nlm.nih.gov/36450604/","study_design":null,"title":"Diagnostic Performance and Clinical Applicability of Blood-Based Biomarkers in a Prospective Memory Clinic Cohort","title_match":true,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/consideration-of-sex-differences-in-the-measurement-and-31811073","doi":"10.1373/jalm.2019.030023","journal":"The journal of applied laboratory medicine","n_participants":null,"pmid":"31811073","source_url":"https://pubmed.ncbi.nlm.nih.gov/31811073/","study_design":null,"title":"Consideration of Sex Differences in the Measurement and Interpretation of Alzheimer Disease-Related Biofluid-Based Biomarkers","title_match":false,"year":2020},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/autosomal-dominant-and-sporadic-late-onset-alzheimer-s-disease-share-35580594","doi":"10.1093/brain/awac181","journal":"Brain : a journal of neurology","n_participants":559,"pmid":"35580594","source_url":"https://pubmed.ncbi.nlm.nih.gov/35580594/","study_design":null,"title":"Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology","title_match":false,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/detection-of-alzheimer-neuropathology-in-alzheimer-and-non-alzheimer-39928343","doi":"10.1001/jamaneurol.2024.5017","journal":"JAMA neurology","n_participants":125,"pmid":"39928343","source_url":"https://pubmed.ncbi.nlm.nih.gov/39928343/","study_design":null,"title":"Detection of Alzheimer Neuropathology in Alzheimer and Non-Alzheimer Clinical Syndromes With Blood-Based Biomarkers","title_match":true,"year":2025},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/association-of-plasma-amyloid-p-tau-gfap-and-nfl-with-csf-clinical-38830138","doi":"10.1212/wnl.0000000000209418","journal":"Neurology","n_participants":89,"pmid":"38830138","source_url":"https://pubmed.ncbi.nlm.nih.gov/38830138/","study_design":"cohort study","title":"Association of Plasma Amyloid, P-Tau, GFAP, and NfL With CSF, Clinical, and Cognitive Features in Patients With Dementia With Lewy Bodies","title_match":true,"year":2024},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/evaluation-of-plasma-biomarkers-for-a-t-n-classification-of-alzheimer-37079306","doi":"10.1001/jamanetworkopen.2023.8214","journal":"JAMA network open","n_participants":746,"pmid":"37079306","source_url":"https://pubmed.ncbi.nlm.nih.gov/37079306/","study_design":"cross-sectional","title":"Evaluation of Plasma Biomarkers for A/T/N Classification of Alzheimer Disease Among Adults of Caribbean Hispanic Ethnicity","title_match":true,"year":2023},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/proteomics-identifies-potential-immunological-drivers-of-39143319","doi":"10.1038/s43587-024-00682-4","journal":"Nature aging","n_participants":null,"pmid":"39143319","source_url":"https://pubmed.ncbi.nlm.nih.gov/39143319/","study_design":null,"title":"Proteomics identifies potential immunological drivers of postinfection brain atrophy and cognitive decline","title_match":false,"year":2024},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/operationalizing-diagnostic-criteria-for-alzheimer-s-disease-and-21255741","doi":"10.1016/j.jalz.2010.11.005","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"21255741","source_url":"https://pubmed.ncbi.nlm.nih.gov/21255741/","study_design":null,"title":"Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 1","title_match":false,"year":2011},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/comparative-neurofilament-light-chain-trajectories-in-csf-and-plasma-39557867","doi":"10.1038/s41467-024-52937-8","journal":"Nature communications","n_participants":567,"pmid":"39557867","source_url":"https://pubmed.ncbi.nlm.nih.gov/39557867/","study_design":"cross-sectional","title":"Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-for-prediction-of-alzheimer-s-disease-37269398","doi":"10.1007/s00401-023-02594-w","journal":"Acta neuropathologica","n_participants":350,"pmid":"37269398","source_url":"https://pubmed.ncbi.nlm.nih.gov/37269398/","study_design":null,"title":"Plasma biomarkers for prediction of Alzheimer's disease neuropathologic change","title_match":true,"year":2023},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/development-of-a-plasma-biomarker-diagnostic-model-incorporating-34662373","doi":"10.1093/clinchem/hvab192","journal":"Clinical chemistry","n_participants":159,"pmid":"34662373","source_url":"https://pubmed.ncbi.nlm.nih.gov/34662373/","study_design":null,"title":"Development of a Plasma Biomarker Diagnostic Model Incorporating Ultrasensitive Digital Immunoassay as a Screening Strategy for Alzheimer Disease in a Chinese Population","title_match":true,"year":2021},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/accuracy-of-biomarker-testing-for-neuropathologically-defined-32340038","doi":"10.7326/m19-3888","journal":"Annals of internal medicine","n_participants":null,"pmid":"32340038","source_url":"https://pubmed.ncbi.nlm.nih.gov/32340038/","study_design":"systematic review","title":"Accuracy of Biomarker Testing for Neuropathologically Defined Alzheimer Disease in Older Adults With Dementia","title_match":false,"year":2020},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/plasma-vegfa-and-pgf-impact-longitudinal-tau-and-cognition-in-38315899","doi":"10.1093/brain/awae034","journal":"Brain : a journal of neurology","n_participants":317,"pmid":"38315899","source_url":"https://pubmed.ncbi.nlm.nih.gov/38315899/","study_design":"longitudinal study","title":"Plasma VEGFA and PGF impact longitudinal tau and cognition in preclinical Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/evaluation-of-plasma-phosphorylated-tau217-for-differentiation-37010841","doi":"10.1001/jamaneurol.2023.0488","journal":"JAMA neurology","n_participants":113,"pmid":"37010841","source_url":"https://pubmed.ncbi.nlm.nih.gov/37010841/","study_design":"cohort study","title":"Evaluation of Plasma Phosphorylated Tau217 for Differentiation Between Alzheimer Disease and Frontotemporal Lobar Degeneration Subtypes Among Patients With Corticobasal Syndrome","title_match":false,"year":2023},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/association-of-bdnf-val66met-with-tau-hyperphosphorylation-and-35099506","doi":"10.1001/jamaneurol.2021.5181","journal":"JAMA neurology","n_participants":527,"pmid":"35099506","source_url":"https://pubmed.ncbi.nlm.nih.gov/35099506/","study_design":"cohort study","title":"Association of BDNF Val66Met With Tau Hyperphosphorylation and Cognition in Dominantly Inherited Alzheimer Disease","title_match":false,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/biomarkers-for-early-diagnosis-of-alzheimer-disease-alzheimer-18363842","doi":"10.1111/j.1582-4934.2008.00313.x","journal":"Journal of cellular and molecular medicine","n_participants":null,"pmid":"18363842","source_url":"https://pubmed.ncbi.nlm.nih.gov/18363842/","study_design":null,"title":"Biomarkers for early diagnosis of Alzheimer disease: 'ALZheimer ASsociated gene'--a new blood biomarker?","title_match":false,"year":2008},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/using-alzheimer-s-disease-blood-tests-to-accelerate-clinical-trial-35934777","doi":"10.1002/alz.12754","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"35934777","source_url":"https://pubmed.ncbi.nlm.nih.gov/35934777/","study_design":null,"title":"Using Alzheimer's disease blood tests to accelerate clinical trial enrollment","title_match":true,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-p-tau181-and-p-tau217-in-patients-with-traumatic-35577574","doi":"10.1212/wnl.0000000000200678","journal":"Neurology","n_participants":18,"pmid":"35577574","source_url":"https://pubmed.ncbi.nlm.nih.gov/35577574/","study_design":null,"title":"Plasma P-tau181 and P-tau217 in Patients With Traumatic Encephalopathy Syndrome With and Without Evidence of Alzheimer Disease Pathology","title_match":true,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/low-plasma-neurofilament-light-levels-associated-with-raised-cortical-31898549","doi":"10.1186/s13195-019-0574-0","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"31898549","source_url":"https://pubmed.ncbi.nlm.nih.gov/31898549/","study_design":null,"title":"Low plasma neurofilament light levels associated with raised cortical microglial activation suggest inflammation acts to protect prodromal Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/abnormal-clotting-of-the-intrinsic-contact-pathway-in-alzheimer-29700007","doi":"10.1182/bloodadvances.2018017798","journal":"Blood advances","n_participants":null,"pmid":"29700007","source_url":"https://pubmed.ncbi.nlm.nih.gov/29700007/","study_design":null,"title":"Abnormal clotting of the intrinsic/contact pathway in Alzheimer disease patients is related to cognitive ability","title_match":false,"year":2018},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-blood-biomarkers-in-patients-with-out-of-hospital-36877496","doi":"10.1001/jamaneurol.2023.0050","journal":"JAMA neurology","n_participants":80,"pmid":"36877496","source_url":"https://pubmed.ncbi.nlm.nih.gov/36877496/","study_design":"case-control study","title":"Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/csf-p-tau181-and-other-biomarkers-in-patients-with-neuronal-36517236","doi":"10.1212/wnl.0000000000201647","journal":"Neurology","n_participants":12,"pmid":"36517236","source_url":"https://pubmed.ncbi.nlm.nih.gov/36517236/","study_design":null,"title":"CSF P-Tau181 and Other Biomarkers in Patients With Neuronal Intranuclear Inclusion Disease","title_match":true,"year":2023},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-for-prognosis-of-cognitive-decline-in-patients-with-35800899","doi":"10.1093/braincomms/fcac155","journal":"Brain communications","n_participants":60,"pmid":"35800899","source_url":"https://pubmed.ncbi.nlm.nih.gov/35800899/","study_design":"cohort study","title":"Plasma biomarkers for prognosis of cognitive decline in patients with mild cognitive impairment","title_match":true,"year":2022},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/blood-derived-mitochondrial-dna-copy-number-is-associated-with-39444005","doi":"10.1186/s13195-024-01601-w","journal":"Alzheimer's research & therapy","n_participants":13799,"pmid":"39444005","source_url":"https://pubmed.ncbi.nlm.nih.gov/39444005/","study_design":null,"title":"Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites","title_match":false,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/effects-of-time-of-the-day-at-sampling-on-csf-and-plasma-levels-of-38909218","doi":"10.1186/s13195-024-01503-x","journal":"Alzheimer's research & therapy","n_participants":20,"pmid":"38909218","source_url":"https://pubmed.ncbi.nlm.nih.gov/38909218/","study_design":null,"title":"Effects of time of the day at sampling on CSF and plasma levels of Alzheimer' disease biomarkers","title_match":false,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/comparative-performance-of-plasma-ptau181-a42-ptau217-a42-ratios-and-40513421","doi":"10.1016/j.ebiom.2025.105805","journal":"EBioMedicine","n_participants":423,"pmid":"40513421","source_url":"https://pubmed.ncbi.nlm.nih.gov/40513421/","study_design":null,"title":"Comparative performance of plasma pTau181/A\u03b242, pTau217/A\u03b242 ratios, and individual measurements in detecting brain amyloidosis","title_match":true,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/plasma-tau-correlates-with-basal-forebrain-atrophy-rates-in-people-at-31801830","doi":"10.1212/wnl.0000000000008696","journal":"Neurology","n_participants":251,"pmid":"31801830","source_url":"https://pubmed.ncbi.nlm.nih.gov/31801830/","study_design":null,"title":"Plasma tau correlates with basal forebrain atrophy rates in people at risk for Alzheimer disease","title_match":false,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-in-mild-cognitive-impairment-patients-relationship-36880887","doi":"10.1111/ene.15762","journal":"European journal of neurology","n_participants":null,"pmid":"36880887","source_url":"https://pubmed.ncbi.nlm.nih.gov/36880887/","study_design":null,"title":"Blood biomarkers in mild cognitive impairment patients: Relationship between analytes and progression to Alzheimer disease dementia","title_match":false,"year":2023},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-plasma-biomarkers-distinguish-clinical-diagnostic-35504263","doi":"10.1159/000524390","journal":"Dementia and geriatric cognitive disorders","n_participants":54,"pmid":"35504263","source_url":"https://pubmed.ncbi.nlm.nih.gov/35504263/","study_design":null,"title":"Alzheimer's Disease Plasma Biomarkers Distinguish Clinical Diagnostic Groups in Memory Clinic Patients","title_match":true,"year":2022},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-a-potential-prognostic-biomarker-of-30951523","doi":"10.1371/journal.pone.0211575","journal":"PloS one","n_participants":24,"pmid":"30951523","source_url":"https://pubmed.ncbi.nlm.nih.gov/30951523/","study_design":null,"title":"Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patients","title_match":false,"year":2019},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/neuronal-pentraxin-1-a-synaptic-derived-plasma-biomarker-in-alzheimer-29501530","doi":"10.1016/j.nbd.2018.02.014","journal":"Neurobiology of disease","n_participants":null,"pmid":"29501530","source_url":"https://pubmed.ncbi.nlm.nih.gov/29501530/","study_design":null,"title":"Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease","title_match":true,"year":2018},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/performance-of-plasma-p-tau217-for-the-detection-of-amyloid-39160628","doi":"10.1186/s13195-024-01555-z","journal":"Alzheimer's research & therapy","n_participants":70,"pmid":"39160628","source_url":"https://pubmed.ncbi.nlm.nih.gov/39160628/","study_design":null,"title":"Performance of plasma p-tau217 for the detection of amyloid-\u03b2 positivity in a memory clinic cohort using an electrochemiluminescence immunoassay","title_match":true,"year":2024},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/evaluation-of-atn-lt-sub-gt-pd-lt-sub-gt-framework-and-biofluid-38306599","doi":"10.1212/wnl.0000000000208033","journal":"Neurology","n_participants":32,"pmid":"38306599","source_url":"https://pubmed.ncbi.nlm.nih.gov/38306599/","study_design":"longitudinal study","title":"Evaluation of ATNPD Framework and Biofluid Markers to Predict Cognitive Decline in Early Parkinson Disease","title_match":false,"year":2024},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/investigating-three-ways-of-measuring-the-intrinsic-capacity-domain-37505993","doi":"10.1093/ageing/afad133","journal":"Age and ageing","n_participants":1389,"pmid":"37505993","source_url":"https://pubmed.ncbi.nlm.nih.gov/37505993/","study_design":"longitudinal study","title":"Investigating three ways of measuring the intrinsic capacity domain of vitality: nutritional status, handgrip strength and ageing biomarkers","title_match":false,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/herpes-viruses-in-the-baltimore-longitudinal-study-of-aging-35985823","doi":"10.1212/wnl.0000000000201036","journal":"Neurology","n_participants":119,"pmid":"35985823","source_url":"https://pubmed.ncbi.nlm.nih.gov/35985823/","study_design":"cross-sectional","title":"Herpes Viruses in the Baltimore Longitudinal Study of Aging: Associations With Brain Volumes, Cognitive Performance, and Plasma Biomarkers","title_match":true,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/plasma-protein-biomarker-model-for-screening-alzheimer-disease-using-35075217","doi":"10.1038/s41598-022-05384-8","journal":"Scientific reports","n_participants":null,"pmid":"35075217","source_url":"https://pubmed.ncbi.nlm.nih.gov/35075217/","study_design":null,"title":"Plasma protein biomarker model for screening Alzheimer disease using multiple reaction monitoring-mass spectrometry","title_match":false,"year":2022},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/cognitive-phenotyping-and-interpretation-of-alzheimer-blood-biomarkers-40181683","doi":"10.1001/jamaneurol.2025.0142","journal":"JAMA neurology","n_participants":2323,"pmid":"40181683","source_url":"https://pubmed.ncbi.nlm.nih.gov/40181683/","study_design":"cohort study","title":"Cognitive Phenotyping and Interpretation of Alzheimer Blood Biomarkers","title_match":false,"year":2025},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/challenges-in-a-biological-definition-of-alzheimer-disease-39353147","doi":"10.1212/wnl.0000000000209884","journal":"Neurology","n_participants":null,"pmid":"39353147","source_url":"https://pubmed.ncbi.nlm.nih.gov/39353147/","study_design":"longitudinal study","title":"Challenges in a Biological Definition of Alzheimer Disease","title_match":false,"year":2024},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-in-relation-to-10-year-change-in-37535203","doi":"10.1007/s11357-023-00876-5","journal":"GeroScience","n_participants":975,"pmid":"37535203","source_url":"https://pubmed.ncbi.nlm.nih.gov/37535203/","study_design":null,"title":"Plasma neurofilament light chain in relation to 10-year change in cognition and neuroimaging markers: a population-based study","title_match":false,"year":2024},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/association-of-plasma-phosphorylated-tau-217-with-clinical-40472304","doi":"10.1212/wnl.0000000000213769","journal":"Neurology","n_participants":731,"pmid":"40472304","source_url":"https://pubmed.ncbi.nlm.nih.gov/40472304/","study_design":"cohort study","title":"Association of Plasma Phosphorylated Tau 217 With Clinical Deterioration Across Alzheimer Disease Stages","title_match":false,"year":2025},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-blood-biomarkers-and-cognition-among-individuals-39913137","doi":"10.1001/jamanetworkopen.2024.58149","journal":"JAMA network open","n_participants":758,"pmid":"39913137","source_url":"https://pubmed.ncbi.nlm.nih.gov/39913137/","study_design":"cohort study","title":"Alzheimer Disease Blood Biomarkers and Cognition Among Individuals With Diabetes and Overweight or Obesity","title_match":false,"year":2025},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-confirm-subjective-cognitive-decline-scd-as-a-40247130","doi":"10.1038/s41380-025-03021-0","journal":"Molecular psychiatry","n_participants":457,"pmid":"40247130","source_url":"https://pubmed.ncbi.nlm.nih.gov/40247130/","study_design":"longitudinal study","title":"Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer\u00b4s disease","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/plasma-alzheimer-s-biomarkers-and-brain-amyloid-in-hispanic-and-non-37671801","doi":"10.1002/alz.13456","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37671801","source_url":"https://pubmed.ncbi.nlm.nih.gov/37671801/","study_design":null,"title":"Plasma Alzheimer's biomarkers and brain amyloid in Hispanic and non-Hispanic older adults","title_match":false,"year":2024},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-total-tau-and-neurofilament-light-chain-levels-and-the-35232820","doi":"10.1212/wnl.0000000000200004","journal":"Neurology","n_participants":379,"pmid":"35232820","source_url":"https://pubmed.ncbi.nlm.nih.gov/35232820/","study_design":null,"title":"Plasma \u03b2-Amyloid, Total-Tau, and Neurofilament Light Chain Levels and the Risk of Stroke: A Prospective Population-Based Study","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-levels-are-associated-with-cortical-31305887","doi":"10.1093/jnen/nlz054","journal":"Journal of neuropathology and experimental neurology","n_participants":149,"pmid":"31305887","source_url":"https://pubmed.ncbi.nlm.nih.gov/31305887/","study_design":null,"title":"Plasma Neurofilament Light Chain Levels Are Associated With Cortical Hypometabolism in Alzheimer Disease Signature Regions","title_match":false,"year":2019},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/association-of-plasma-biomarkers-with-longitudinal-atrophy-and-40063856","doi":"10.1212/wnl.0000000000213438","journal":"Neurology","n_participants":1240,"pmid":"40063856","source_url":"https://pubmed.ncbi.nlm.nih.gov/40063856/","study_design":"cohort study","title":"Association of Plasma Biomarkers With Longitudinal Atrophy and Microvascular Burden on MRI Across Neurodegenerative and Cerebrovascular Diseases","title_match":true,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/longitudinal-changes-in-blood-biomarkers-of-clinical-alzheimer-36446595","doi":"10.1212/wnl.0000000000201289","journal":"Neurology","n_participants":1327,"pmid":"36446595","source_url":"https://pubmed.ncbi.nlm.nih.gov/36446595/","study_design":"longitudinal study","title":"Longitudinal Changes in Blood Biomarkers of Clinical Alzheimer Disease in a Biracial Population Sample","title_match":false,"year":2023},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/physical-activity-alzheimer-plasma-biomarkers-and-cognition-40042844","doi":"10.1001/jamanetworkopen.2025.0096","journal":"JAMA network open","n_participants":1144,"pmid":"40042844","source_url":"https://pubmed.ncbi.nlm.nih.gov/40042844/","study_design":"cross-sectional","title":"Physical Activity, Alzheimer Plasma Biomarkers, and Cognition","title_match":true,"year":2025},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/temporal-dynamics-and-biological-variability-of-alzheimer-biomarkers-39960728","doi":"10.1001/jamaneurol.2024.5263","journal":"JAMA neurology","n_participants":2611,"pmid":"39960728","source_url":"https://pubmed.ncbi.nlm.nih.gov/39960728/","study_design":"cohort study","title":"Temporal Dynamics and Biological Variability of Alzheimer Biomarkers","title_match":false,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/associations-between-blood-based-biomarkers-and-cognitive-and-38626384","doi":"10.1212/wnl.0000000000209307","journal":"Neurology","n_participants":1938,"pmid":"38626384","source_url":"https://pubmed.ncbi.nlm.nih.gov/38626384/","study_design":null,"title":"Associations Between Blood-Based Biomarkers and Cognitive and Functional Trajectories Among Participants of the MEMENTO Cohort","title_match":true,"year":2024},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/focused-ultrasound-mediated-liquid-biopsy-in-a-tauopathy-mouse-model-36719290","doi":"10.1148/radiol.220869","journal":"Radiology","n_participants":null,"pmid":"36719290","source_url":"https://pubmed.ncbi.nlm.nih.gov/36719290/","study_design":null,"title":"Focused Ultrasound-mediated Liquid Biopsy in a Tauopathy Mouse Model","title_match":false,"year":2023},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-and-risk-of-onset-of-mild-cognitive-impairment-39724536","doi":"10.1212/wnl.0000000000210225","journal":"Neurology","n_participants":271,"pmid":"39724536","source_url":"https://pubmed.ncbi.nlm.nih.gov/39724536/","study_design":"longitudinal study","title":"Blood-Based Biomarkers and Risk of Onset of Mild Cognitive Impairment Over the Short and Long Term","title_match":true,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/vascular-endothelial-cadherin-as-a-marker-of-endothelial-injury-in-36342663","doi":"10.1002/acn3.51685","journal":"Annals of clinical and translational neurology","n_participants":700,"pmid":"36342663","source_url":"https://pubmed.ncbi.nlm.nih.gov/36342663/","study_design":null,"title":"Vascular endothelial-cadherin as a marker of endothelial injury in preclinical Alzheimer disease","title_match":false,"year":2022},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/dissection-of-blood-brain-barrier-dysfunction-through-csf-pdgfr-and-40239464","doi":"10.1016/j.ebiom.2025.105694","journal":"EBioMedicine","n_participants":23,"pmid":"40239464","source_url":"https://pubmed.ncbi.nlm.nih.gov/40239464/","study_design":null,"title":"Dissection of blood-brain barrier dysfunction through CSF PDGFR\u03b2 and amyloid, tau, neuroinflammation, and synaptic CSF biomarkers in neurodegenerative disorders","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/cognitively-normal-apoe-4-carriers-have-specific-elevation-of-csf-33765432","doi":"10.1016/j.neurobiolaging.2021.02.008","journal":"Neurobiology of aging","n_participants":274,"pmid":"33765432","source_url":"https://pubmed.ncbi.nlm.nih.gov/33765432/","study_design":null,"title":"Cognitively normal APOE \u03b54 carriers have specific elevation of CSF SNAP-25","title_match":false,"year":2021},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/disentangling-relationships-between-alzheimer-s-disease-plasma-39701863","doi":"10.1016/j.ebiom.2024.105504","journal":"EBioMedicine","n_participants":null,"pmid":"39701863","source_url":"https://pubmed.ncbi.nlm.nih.gov/39701863/","study_design":null,"title":"Disentangling relationships between Alzheimer's disease plasma biomarkers and established biomarkers in patients of tertiary memory clinics","title_match":true,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/relationships-of-cognitive-measures-with-cerebrospinal-fluid-but-not-38038976","doi":"10.1002/ana.26838","journal":"Annals of neurology","n_participants":null,"pmid":"38038976","source_url":"https://pubmed.ncbi.nlm.nih.gov/38038976/","study_design":null,"title":"Relationships of Cognitive Measures with Cerebrospinal Fluid but Not Imaging Biomarkers of Alzheimer Disease Vary between Black and White Individuals","title_match":false,"year":2024},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/simultaneously-evaluating-the-effect-of-baseline-levels-and-30569014","doi":"10.1016/j.trci.2018.10.009","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":262,"pmid":"30569014","source_url":"https://pubmed.ncbi.nlm.nih.gov/30569014/","study_design":"longitudinal study","title":"Simultaneously evaluating the effect of baseline levels and longitudinal changes in disease biomarkers on cognition in dominantly inherited Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/psychosis-in-alzheimer-disease-and-elevations-in-disease-relevant-38922609","doi":"10.1001/jamapsychiatry.2024.1389","journal":"JAMA psychiatry","n_participants":752,"pmid":"38922609","source_url":"https://pubmed.ncbi.nlm.nih.gov/38922609/","study_design":"cohort study","title":"Psychosis in Alzheimer Disease and Elevations in Disease-Relevant Biomarkers","title_match":false,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-of-brain-injury-and-their-association-with-brain-38861647","doi":"10.2337/dc24-0229","journal":"Diabetes care","n_participants":373,"pmid":"38861647","source_url":"https://pubmed.ncbi.nlm.nih.gov/38861647/","study_design":null,"title":"Plasma Biomarkers of Brain Injury and Their Association With Brain MRI and Cognition in Type 1 Diabetes","title_match":true,"year":2024},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/genetic-architecture-of-plasma-alzheimer-disease-biomarkers-37208024","doi":"10.1093/hmg/ddad087","journal":"Human molecular genetics","n_participants":1467,"pmid":"37208024","source_url":"https://pubmed.ncbi.nlm.nih.gov/37208024/","study_design":null,"title":"Genetic architecture of plasma Alzheimer disease biomarkers","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/aerobic-exercise-does-not-affect-serum-neurofilament-light-in-36761410","doi":"10.3389/fnins.2023.1108191","journal":"Frontiers in neuroscience","n_participants":136,"pmid":"36761410","source_url":"https://pubmed.ncbi.nlm.nih.gov/36761410/","study_design":null,"title":"Aerobic exercise does not affect serum neurofilament light in patients with mild Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/genome-wide-association-study-identifies-two-loci-influencing-plasma-29747637","doi":"10.1186/s12920-018-0364-8","journal":"BMC medical genomics","n_participants":179,"pmid":"29747637","source_url":"https://pubmed.ncbi.nlm.nih.gov/29747637/","study_design":"longitudinal study","title":"Genome-wide association study identifies two loci influencing plasma neurofilament light levels","title_match":false,"year":2018},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/early-microglial-and-astrocyte-reactivity-in-preclinical-alzheimer-s-40747577","doi":"10.1002/alz.70502","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40747577","source_url":"https://pubmed.ncbi.nlm.nih.gov/40747577/","study_design":null,"title":"Early microglial and astrocyte reactivity in preclinical Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/plasma-glial-fibrillary-acid-protein-and-phosphorated-tau-181-39560478","doi":"10.1148/radiol.233019","journal":"Radiology","n_participants":50,"pmid":"39560478","source_url":"https://pubmed.ncbi.nlm.nih.gov/39560478/","study_design":null,"title":"Plasma Glial Fibrillary Acid Protein and Phosphorated Tau 181 Association with Presynaptic Density-Dependent Tau Pathology at 18F-SynVesT-1 Brain PET Imaging","title_match":false,"year":2024},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-of-alzheimer-disease-in-women-with-and-without-hiv-38019518","doi":"10.1001/jamanetworkopen.2023.44194","journal":"JAMA network open","n_participants":307,"pmid":"38019518","source_url":"https://pubmed.ncbi.nlm.nih.gov/38019518/","study_design":"cohort study","title":"Plasma Biomarkers of Alzheimer Disease in Women With and Without HIV","title_match":true,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/adamts4-is-involved-in-the-production-of-the-alzheimer-disease-36721026","doi":"10.1038/s41380-023-01946-y","journal":"Molecular psychiatry","n_participants":null,"pmid":"36721026","source_url":"https://pubmed.ncbi.nlm.nih.gov/36721026/","study_design":null,"title":"ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711","title_match":false,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/amyloid-dependent-and-independent-genetic-pathways-regulating-csf-tau-35641311","doi":"10.1212/wnl.0000000000200605","journal":"Neurology","n_participants":751,"pmid":"35641311","source_url":"https://pubmed.ncbi.nlm.nih.gov/35641311/","study_design":null,"title":"\u03b2-Amyloid-Dependent and -Independent Genetic Pathways Regulating CSF Tau Biomarkers in Alzheimer Disease","title_match":false,"year":2022},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/serum-nfl-in-alzheimer-dementia-results-of-the-prospective-dementia-35334608","doi":"10.3390/medicina58030433","journal":"Medicina (Kaunas, Lithuania)","n_participants":237,"pmid":"35334608","source_url":"https://pubmed.ncbi.nlm.nih.gov/35334608/","study_design":"cross-sectional","title":"Serum NfL in Alzheimer Dementia: Results of the Prospective Dementia Registry Austria","title_match":true,"year":2022},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/role-of-inflammatory-and-hemostatic-biomarkers-in-alzheimer-s-and-29061429","doi":"10.1016/j.ajp.2017.04.015","journal":"Asian journal of psychiatry","n_participants":68,"pmid":"29061429","source_url":"https://pubmed.ncbi.nlm.nih.gov/29061429/","study_design":null,"title":"Role of inflammatory and hemostatic biomarkers in Alzheimer's and vascular dementia - A pilot study from a tertiary center in Northern India","title_match":false,"year":2017},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/high-sensitivity-plasma-proteomics-reveals-disease-specific-41250190","doi":"10.1186/s13024-025-00909-x","journal":"Molecular neurodegeneration","n_participants":3232,"pmid":"41250190","source_url":"https://pubmed.ncbi.nlm.nih.gov/41250190/","study_design":null,"title":"High-sensitivity plasma proteomics reveals disease-specific signatures and predictive biomarkers of Alzheimer's disease phenotypes in a large mixed-dementia cohort","title_match":false,"year":2025},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/associations-between-changes-in-levels-of-phosphorylated-tau-and-40373247","doi":"10.1212/wnl.0000000000213676","journal":"Neurology","n_participants":431,"pmid":"40373247","source_url":"https://pubmed.ncbi.nlm.nih.gov/40373247/","study_design":"longitudinal study","title":"Associations Between Changes in Levels of Phosphorylated Tau and Severity of Cognitive Impairment in Early Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/nonalcoholic-fatty-liver-disease-and-longitudinal-change-in-imaging-38471046","doi":"10.1212/wnl.0000000000209203","journal":"Neurology","n_participants":1706,"pmid":"38471046","source_url":"https://pubmed.ncbi.nlm.nih.gov/38471046/","study_design":null,"title":"Nonalcoholic Fatty Liver Disease and Longitudinal Change in Imaging and Plasma Biomarkers of Alzheimer Disease and Vascular Pathology","title_match":true,"year":2024},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/cerebral-amyloid-angiopathy-and-downstream-alzheimer-disease-plasma-40343697","doi":"10.1001/jamanetworkopen.2025.8842","journal":"JAMA network open","n_participants":1708,"pmid":"40343697","source_url":"https://pubmed.ncbi.nlm.nih.gov/40343697/","study_design":"cohort study","title":"Cerebral Amyloid Angiopathy and Downstream Alzheimer Disease Plasma Biomarkers","title_match":true,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/tnfr-1-and-gdf-15-are-associated-with-plasma-neurofilament-light-36508390","doi":"10.1093/gerona/glac244","journal":"The journals of gerontology. Series A, Biological sciences and medical sciences","n_participants":116,"pmid":"36508390","source_url":"https://pubmed.ncbi.nlm.nih.gov/36508390/","study_design":"cross-sectional","title":"TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study","title_match":false,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/associations-of-plasma-neurofilament-light-chain-and-progranulin-with-34908159","doi":"10.1111/jgs.17604","journal":"Journal of the American Geriatrics Society","n_participants":403,"pmid":"34908159","source_url":"https://pubmed.ncbi.nlm.nih.gov/34908159/","study_design":"cross-sectional","title":"Associations of plasma neurofilament light chain and progranulin with frailty in older adults","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/molecular-neuropsychology-creation-of-test-specific-blood-biomarker-24107792","doi":"10.1159/000345605","journal":"Dementia and geriatric cognitive disorders","n_participants":395,"pmid":"24107792","source_url":"https://pubmed.ncbi.nlm.nih.gov/24107792/","study_design":null,"title":"Molecular neuropsychology: creation of test-specific blood biomarker algorithms","title_match":false,"year":2014},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/effect-of-obicetrapib-a-potent-cholesteryl-ester-transfer-protein-41109840","doi":"10.1016/j.tjpad.2025.100394","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"41109840","source_url":"https://pubmed.ncbi.nlm.nih.gov/41109840/","study_design":"clinical trial","title":"Effect of obicetrapib, a potent cholesteryl ester transfer protein inhibitor, on p-tau217 levels in patients with cardiovascular disease","title_match":true,"year":2026},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/olfaction-and-plasma-biomarkers-of-alzheimer-disease-and-40373252","doi":"10.1212/wnl.0000000000213706","journal":"Neurology","n_participants":1545,"pmid":"40373252","source_url":"https://pubmed.ncbi.nlm.nih.gov/40373252/","study_design":"cross-sectional","title":"Olfaction and Plasma Biomarkers of Alzheimer Disease and Neurodegeneration in the Atherosclerosis Risk in Communities Study","title_match":true,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/comparison-of-plasma-p-tau217-and-lt-sup-gt-18-lt-sup-gt-f-fdg-pet-39715476","doi":"10.1212/wnl.0000000000210211","journal":"Neurology","n_participants":81,"pmid":"39715476","source_url":"https://pubmed.ncbi.nlm.nih.gov/39715476/","study_design":null,"title":"Comparison of Plasma p-tau217 and [18F]FDG-PET for Identifying Alzheimer Disease in People With Early-Onset or Atypical Dementia","title_match":true,"year":2025},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/prognostic-value-of-alzheimer-s-disease-plasma-biomarkers-in-the-39253733","doi":"10.1016/j.lanepe.2024.101030","journal":"The Lancet regional health. Europe","n_participants":1007,"pmid":"39253733","source_url":"https://pubmed.ncbi.nlm.nih.gov/39253733/","study_design":"longitudinal study","title":"Prognostic value of Alzheimer's disease plasma biomarkers in the oldest-old: a prospective primary care-based study","title_match":true,"year":2024},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/diagnostic-utility-of-cerebrospinal-fluid-biomarkers-in-patients-with-37897306","doi":"10.1002/ana.26822","journal":"Annals of neurology","n_participants":44,"pmid":"37897306","source_url":"https://pubmed.ncbi.nlm.nih.gov/37897306/","study_design":"cross-sectional","title":"Diagnostic Utility of Cerebrospinal Fluid Biomarkers in Patients with Rapidly Progressive Dementia","title_match":false,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/cardiovascular-health-and-biomarkers-of-neurodegenerative-disease-in-40067299","doi":"10.1001/jamanetworkopen.2025.0527","journal":"JAMA network open","n_participants":1018,"pmid":"40067299","source_url":"https://pubmed.ncbi.nlm.nih.gov/40067299/","study_design":"cohort study","title":"Cardiovascular Health and Biomarkers of Neurodegenerative Disease in Older Adults","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/advanced-structural-brain-aging-in-preclinical-autosomal-dominant-38111006","doi":"10.1186/s13024-023-00688-3","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"38111006","source_url":"https://pubmed.ncbi.nlm.nih.gov/38111006/","study_design":null,"title":"Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease","title_match":false,"year":2023},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/blood-based-biomarker-for-optimization-of-early-and-differential-35858611","doi":"10.1055/a-1839-6237","journal":"Fortschritte der Neurologie-Psychiatrie","n_participants":null,"pmid":"35858611","source_url":"https://pubmed.ncbi.nlm.nih.gov/35858611/","study_design":"meta-analysis","title":"[Blood Based Biomarker for Optimization of Early and Differential Diagnosis of Alzheimer's Dementia]","title_match":true,"year":2022},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/a-population-based-study-of-head-injury-cognitive-function-and-33694298","doi":"10.1002/acn3.51331","journal":"Annals of clinical and translational neurology","n_participants":502,"pmid":"33694298","source_url":"https://pubmed.ncbi.nlm.nih.gov/33694298/","study_design":null,"title":"A population-based study of head injury, cognitive function and pathological markers","title_match":false,"year":2021},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/integrating-plasma-p-tau217-and-digital-cognitive-assessments-for-40491259","doi":"10.1002/alz.70355","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":954,"pmid":"40491259","source_url":"https://pubmed.ncbi.nlm.nih.gov/40491259/","study_design":null,"title":"Integrating plasma p-tau217 and digital cognitive assessments for early detection in Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/cognitive-impact-of-multidomain-intervention-and-omega-3-according-to-37872582","doi":"10.1186/s13195-023-01325-3","journal":"Alzheimer's research & therapy","n_participants":483,"pmid":"37872582","source_url":"https://pubmed.ncbi.nlm.nih.gov/37872582/","study_design":null,"title":"Cognitive impact of multidomain intervention and omega 3 according to blood A\u03b242/40 ratio: a subgroup analysis from the randomized MAPT trial","title_match":false,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/demographic-and-clinical-characteristics-associated-with-serum-gfap-37813589","doi":"10.1212/wnl.0000000000207706","journal":"Neurology","n_participants":1156,"pmid":"37813589","source_url":"https://pubmed.ncbi.nlm.nih.gov/37813589/","study_design":null,"title":"Demographic and Clinical Characteristics Associated With Serum GFAP Levels in an Ethnically Diverse Cohort","title_match":true,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/combined-effects-of-synaptic-and-axonal-integrity-on-longitudinal-36041868","doi":"10.1212/wnl.0000000000201165","journal":"Neurology","n_participants":null,"pmid":"36041868","source_url":"https://pubmed.ncbi.nlm.nih.gov/36041868/","study_design":"longitudinal study","title":"Combined Effects of Synaptic and Axonal Integrity on Longitudinal Gray Matter Atrophy in Cognitively Unimpaired Adults","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/dyrk1a-and-activity-dependent-neuroprotective-protein-comparative-35740400","doi":"10.3390/biomedicines10061380","journal":"Biomedicines","n_participants":null,"pmid":"35740400","source_url":"https://pubmed.ncbi.nlm.nih.gov/35740400/","study_design":"cross-sectional","title":"DYRK1A and Activity-Dependent Neuroprotective Protein Comparative Diagnosis Interest in Cerebrospinal Fluid and Plasma in the Context of Alzheimer-Related Cognitive Impairment in Down Syndrome Patients","title_match":false,"year":2022},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/clinical-utility-of-amyloid-imaging-in-a-complex-case-of-corticobasal-26225355","doi":"10.4172/2329-6895.1000194","journal":"Journal of neurological disorders","n_participants":null,"pmid":"26225355","source_url":"https://pubmed.ncbi.nlm.nih.gov/26225355/","study_design":null,"title":"Clinical Utility of Amyloid Imaging in a Complex Case of Corticobasal Syndrome Presenting with Psychiatric Symptoms","title_match":false,"year":2014},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/longitudinal-blood-based-biomarkers-and-clinical-progression-in-41335440","doi":"10.1001/jamanetworkopen.2025.45862","journal":"JAMA network open","n_participants":298,"pmid":"41335440","source_url":"https://pubmed.ncbi.nlm.nih.gov/41335440/","study_design":"cohort study","title":"Longitudinal Blood-Based Biomarkers and Clinical Progression in Subjective Cognitive Decline","title_match":true,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/association-of-enlarged-perivascular-spaces-with-early-serum-and-40845262","doi":"10.1212/wnl.0000000000213836","journal":"Neurology","n_participants":979,"pmid":"40845262","source_url":"https://pubmed.ncbi.nlm.nih.gov/40845262/","study_design":"cross-sectional","title":"Association of Enlarged Perivascular Spaces With Early Serum and Neuroimaging Biomarkers of Alzheimer Disease Pathology","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/analytical-validation-and-performance-of-a-blood-based-p-tau217-39836199","doi":"10.1093/jalm/jfae155","journal":"The journal of applied laboratory medicine","n_participants":1091,"pmid":"39836199","source_url":"https://pubmed.ncbi.nlm.nih.gov/39836199/","study_design":null,"title":"Analytical Validation and Performance of a Blood-Based P-tau217 Diagnostic Test for Alzheimer Disease","title_match":true,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/strong-diagnostic-performance-of-plasma-ptau217-for-csf-biomarker-39666133","doi":"10.1007/s00415-024-12732-3","journal":"Journal of neurology","n_participants":null,"pmid":"39666133","source_url":"https://pubmed.ncbi.nlm.nih.gov/39666133/","study_design":null,"title":"Strong diagnostic performance of plasma ptau217 for CSF biomarker-defined young-onset Alzheimer disease in a diagnostically heterogeneous clinical cohort","title_match":true,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/proteomic-clusters-underlie-heterogeneity-in-preclinical-alzheimer-s-36542469","doi":"10.1093/brain/awac484","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"36542469","source_url":"https://pubmed.ncbi.nlm.nih.gov/36542469/","study_design":"longitudinal study","title":"Proteomic clusters underlie heterogeneity in preclinical Alzheimer's disease progression","title_match":false,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/csf-phosphorylated-tau-as-an-indicator-of-subsequent-tau-accumulation-35764037","doi":"10.1016/j.neurobiolaging.2022.02.015","journal":"Neurobiology of aging","n_participants":143,"pmid":"35764037","source_url":"https://pubmed.ncbi.nlm.nih.gov/35764037/","study_design":"longitudinal study","title":"CSF phosphorylated tau as an indicator of subsequent tau accumulation","title_match":false,"year":2022},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-217-and-amyloid-burden-in-older-adults-41324928","doi":"10.1001/jamaneurol.2025.4721","journal":"JAMA neurology","n_participants":7834,"pmid":"41324928","source_url":"https://pubmed.ncbi.nlm.nih.gov/41324928/","study_design":"systematic review","title":"Plasma Phosphorylated Tau 217 and Amyloid Burden in Older Adults Without Cognitive Impairment: A Meta-Analysis","title_match":false,"year":2026},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-as-a-biomarker-of-alzheimer-s-disease-pathology-in-41213934","doi":"10.1038/s41467-025-65882-x","journal":"Nature communications","n_participants":2329,"pmid":"41213934","source_url":"https://pubmed.ncbi.nlm.nih.gov/41213934/","study_design":null,"title":"Plasma p-tau217 as a biomarker of Alzheimer's disease pathology in individuals with Down syndrome","title_match":true,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-vascular-disease-and-blood-brain-barrier-41052375","doi":"10.1212/wnl.0000000000214220","journal":"Neurology","n_participants":488,"pmid":"41052375","source_url":"https://pubmed.ncbi.nlm.nih.gov/41052375/","study_design":null,"title":"Alzheimer Disease, Vascular Disease, and Blood-Brain Barrier Permeability Biomarkers in Middle-Aged Adults","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/plasma-tau-biomarkers-are-distinctly-associated-with-tau-tangles-and-40791093","doi":"10.1002/alz.70562","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40791093","source_url":"https://pubmed.ncbi.nlm.nih.gov/40791093/","study_design":null,"title":"Plasma tau biomarkers are distinctly associated with tau tangles and decreased with Lewy body pathology","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/imaging-and-fluid-biomarkers-of-alzheimer-disease-complementation-40480828","doi":"10.2967/jnumed.125.270152","journal":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","n_participants":null,"pmid":"40480828","source_url":"https://pubmed.ncbi.nlm.nih.gov/40480828/","study_design":null,"title":"Imaging and Fluid Biomarkers of Alzheimer Disease: Complementation Rather Than Competition","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/generalizability-of-tau-and-amyloid-plasma-biomarkers-in-alzheimer-s-40133765","doi":"10.1002/alz.14367","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":2086,"pmid":"40133765","source_url":"https://pubmed.ncbi.nlm.nih.gov/40133765/","study_design":null,"title":"Generalizability of tau and amyloid plasma biomarkers in Alzheimer's disease cohorts of diverse genetic ancestries","title_match":true,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/lumipulse-measured-cerebrospinal-fluid-biomarkers-for-the-early-39496102","doi":"10.1212/wnl.0000000000209866","journal":"Neurology","n_participants":null,"pmid":"39496102","source_url":"https://pubmed.ncbi.nlm.nih.gov/39496102/","study_design":null,"title":"Lumipulse-Measured Cerebrospinal Fluid Biomarkers for the Early Detection of Alzheimer Disease","title_match":false,"year":2024},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/plasma-beta-amyloid-and-white-matter-lesions-in-ad-mci-and-cerebral-16401840","doi":"10.1212/01.wnl.0000191403.95453.6a","journal":"Neurology","n_participants":54,"pmid":"16401840","source_url":"https://pubmed.ncbi.nlm.nih.gov/16401840/","study_design":"cross-sectional","title":"Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy","title_match":false,"year":2006},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/plasma-multianalyte-profiling-in-mild-cognitive-impairment-and-22855860","doi":"10.1212/wnl.0b013e318266fa70","journal":"Neurology","n_participants":566,"pmid":"22855860","source_url":"https://pubmed.ncbi.nlm.nih.gov/22855860/","study_design":null,"title":"Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/csf-biomarkers-for-alzheimer-disease-correlate-with-cortical-brain-22517093","doi":"10.1212/wnl.0b013e3182563bd0","journal":"Neurology","n_participants":182,"pmid":"22517093","source_url":"https://pubmed.ncbi.nlm.nih.gov/22517093/","study_design":null,"title":"CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings","title_match":false,"year":2012},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/associations-between-cerebral-small-vessel-disease-and-alzheimer-24818585","doi":"10.1001/jamaneurol.2014.754","journal":"JAMA neurology","n_participants":914,"pmid":"24818585","source_url":"https://pubmed.ncbi.nlm.nih.gov/24818585/","study_design":"cross-sectional","title":"Associations between cerebral small-vessel disease and Alzheimer disease pathology as measured by cerebrospinal fluid biomarkers","title_match":false,"year":2014},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-levels-of-apolipoprotein-e-and-risk-of-dementia-in-the-general-25469919","doi":"10.1002/ana.24326","journal":"Annals of neurology","n_participants":75708,"pmid":"25469919","source_url":"https://pubmed.ncbi.nlm.nih.gov/25469919/","study_design":null,"title":"Plasma levels of apolipoprotein E and risk of dementia in the general population","title_match":false,"year":2015},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/mediterranean-diet-alzheimer-disease-biomarkers-and-brain-atrophy-in-33952652","doi":"10.1212/wnl.0000000000012067","journal":"Neurology","n_participants":512,"pmid":"33952652","source_url":"https://pubmed.ncbi.nlm.nih.gov/33952652/","study_design":"cross-sectional","title":"Mediterranean Diet, Alzheimer Disease Biomarkers and Brain Atrophy in Old Age","title_match":false,"year":2021},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/metal-protein-attenuation-with-iodochlorhydroxyquin-clioquinol-14676042","doi":"10.1001/archneur.60.12.1685","journal":"Archives of neurology","n_participants":null,"pmid":"14676042","source_url":"https://pubmed.ncbi.nlm.nih.gov/14676042/","study_design":"clinical trial","title":"Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial","title_match":false,"year":2003},{"alzhub_score":81,"alzhub_url":"https://alzhub.org/study/a-randomized-double-blind-placebo-controlled-trial-of-resveratrol-for-26362286","doi":"10.1212/wnl.0000000000002035","journal":"Neurology","n_participants":119,"pmid":"26362286","source_url":"https://pubmed.ncbi.nlm.nih.gov/26362286/","study_design":"clinical trial","title":"A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease","title_match":false,"year":2015},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/efficacy-of-ppar-agonist-pioglitazone-in-mild-alzheimer-disease-19923038","doi":"10.1016/j.neurobiolaging.2009.10.009","journal":"Neurobiology of aging","n_participants":21,"pmid":"19923038","source_url":"https://pubmed.ncbi.nlm.nih.gov/19923038/","study_design":null,"title":"Efficacy of PPAR-\u03b3 agonist pioglitazone in mild Alzheimer disease","title_match":false,"year":2011},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/phase-2-safety-trial-targeting-amyloid-beta-production-with-a-gamma-18695053","doi":"10.1001/archneur.65.8.1031","journal":"Archives of neurology","n_participants":15,"pmid":"18695053","source_url":"https://pubmed.ncbi.nlm.nih.gov/18695053/","study_design":null,"title":"Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease","title_match":false,"year":2008},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/effects-of-a-gamma-secretase-inhibitor-in-a-randomized-study-of-16505324","doi":"10.1212/01.wnl.0000198762.41312.e1","journal":"Neurology","n_participants":70,"pmid":"16505324","source_url":"https://pubmed.ncbi.nlm.nih.gov/16505324/","study_design":null,"title":"Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease","title_match":false,"year":2006},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/a-single-ascending-dose-study-of-bapineuzumab-in-patients-with-20505438","doi":"10.1097/wad.0b013e3181c53b00","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"20505438","source_url":"https://pubmed.ncbi.nlm.nih.gov/20505438/","study_design":"clinical trial","title":"A single ascending dose study of bapineuzumab in patients with Alzheimer disease","title_match":false,"year":2010},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/exploratory-tau-biomarker-results-from-a-multiple-ascending-dose-37902726","doi":"10.1001/jamaneurol.2023.3861","journal":"JAMA neurology","n_participants":13,"pmid":"37902726","source_url":"https://pubmed.ncbi.nlm.nih.gov/37902726/","study_design":"clinical trial","title":"Exploratory Tau Biomarker Results From a Multiple Ascending-Dose Study of BIIB080 in Alzheimer Disease: A Randomized Clinical Trial","title_match":false,"year":2023},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/safety-and-pharmacology-of-a-single-intravenous-dose-of-ponezumab-in-23334070","doi":"10.1097/wnf.0b013e31827db49b","journal":"Clinical neuropharmacology","n_participants":null,"pmid":"23334070","source_url":"https://pubmed.ncbi.nlm.nih.gov/23334070/","study_design":null,"title":"Safety and pharmacology of a single intravenous dose of ponezumab in subjects with mild-to-moderate Alzheimer disease: a phase I, randomized, placebo-controlled, double-blind, dose-escalation study","title_match":false,"year":2013},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/a-novel-abeta-isoform-pattern-in-csf-reflects-gamma-secretase-20350302","doi":"10.1186/alzrt30","journal":"Alzheimer's research & therapy","n_participants":35,"pmid":"20350302","source_url":"https://pubmed.ncbi.nlm.nih.gov/20350302/","study_design":null,"title":"A novel Abeta isoform pattern in CSF reflects gamma-secretase inhibition in Alzheimer disease","title_match":false,"year":2010},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/neuroprotective-effect-of-trans-resveratrol-in-mild-to-moderate-34402024","doi":"10.1007/s40120-021-00271-2","journal":"Neurology and therapy","n_participants":15,"pmid":"34402024","source_url":"https://pubmed.ncbi.nlm.nih.gov/34402024/","study_design":"case-control study","title":"Neuroprotective Effect of Trans-Resveratrol in Mild to Moderate Alzheimer Disease: A Randomized, Double-Blind Trial","title_match":false,"year":2021},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/effect-of-simvastatin-on-csf-alzheimer-disease-biomarkers-in-28821686","doi":"10.1212/wnl.0000000000004392","journal":"Neurology","n_participants":null,"pmid":"28821686","source_url":"https://pubmed.ncbi.nlm.nih.gov/28821686/","study_design":null,"title":"Effect of simvastatin on CSF Alzheimer disease biomarkers in cognitively normal adults","title_match":false,"year":2017},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/plasma-abeta-homocysteine-and-cognition-the-vitamin-intervention-for-19153374","doi":"10.1212/01.wnl.0000339486.63862.db","journal":"Neurology","n_participants":150,"pmid":"19153374","source_url":"https://pubmed.ncbi.nlm.nih.gov/19153374/","study_design":"randomized controlled trial","title":"Plasma Abeta, homocysteine, and cognition: the Vitamin Intervention for Stroke Prevention (VISP) trial","title_match":true,"year":2009},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/association-of-plasma-phosphorylated-tau-with-the-response-to-37657939","doi":"10.1212/wnl.0000000000207755","journal":"Neurology","n_participants":45,"pmid":"37657939","source_url":"https://pubmed.ncbi.nlm.nih.gov/37657939/","study_design":null,"title":"Association of Plasma Phosphorylated Tau With the Response to Neflamapimod Treatment in Patients With Dementia With Lewy Bodies","title_match":false,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/three-week-nutritional-supplementation-effect-on-long-term-21878804","doi":"10.1097/wad.0b013e31822c5bb3","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"21878804","source_url":"https://pubmed.ncbi.nlm.nih.gov/21878804/","study_design":null,"title":"Three-week nutritional supplementation effect on long-term nutritional status of patients with mild Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/phase-2a-proof-of-concept-double-blind-randomized-placebo-controlled-39671543","doi":"10.1212/wnl.0000000000210152","journal":"Neurology","n_participants":47,"pmid":"39671543","source_url":"https://pubmed.ncbi.nlm.nih.gov/39671543/","study_design":null,"title":"Phase 2A Proof-of-Concept Double-Blind, Randomized, Placebo-Controlled Trial of Nicotinamide in Early Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/digital-memory-assessments-and-plasma-ptau217-enable-efficient-41653883","doi":"10.1016/j.tjpad.2026.100503","journal":"The journal of prevention of Alzheimer's disease","n_participants":818,"pmid":"41653883","source_url":"https://pubmed.ncbi.nlm.nih.gov/41653883/","study_design":null,"title":"Digital memory assessments and plasma pTau217 enable efficient preclinical Alzheimer's trials","title_match":true,"year":2026},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/brain-imaging-and-fluid-biomarker-analysis-in-young-adults-at-genetic-23137948","doi":"10.1016/s1474-4422(12)70228-4","journal":"The Lancet. Neurology","n_participants":44,"pmid":"23137948","source_url":"https://pubmed.ncbi.nlm.nih.gov/23137948/","study_design":null,"title":"Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study","title_match":false,"year":2012},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/cognitive-effects-of-intentional-weight-loss-in-elderly-obese-26713821","doi":"10.1210/jc.2015-2315","journal":"The Journal of clinical endocrinology and metabolism","n_participants":40,"pmid":"26713821","source_url":"https://pubmed.ncbi.nlm.nih.gov/26713821/","study_design":null,"title":"Cognitive Effects of Intentional Weight Loss in Elderly Obese Individuals With Mild Cognitive Impairment","title_match":false,"year":2016},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/novel-risk-markers-and-long-term-outcomes-of-delirium-the-successful-22999782","doi":"10.1016/j.jamda.2012.08.004","journal":"Journal of the American Medical Directors Association","n_participants":550,"pmid":"22999782","source_url":"https://pubmed.ncbi.nlm.nih.gov/22999782/","study_design":"cohort study","title":"Novel risk markers and long-term outcomes of delirium: the successful aging after elective surgery (SAGES) study design and methods","title_match":false,"year":2012},{"alzhub_score":78,"alzhub_url":"https://alzhub.org/study/blood-phosphorylated-tau-181-as-a-biomarker-for-alzheimer-s-disease-a-32333900","doi":"10.1016/s1474-4422(20)30071-5","journal":"The Lancet. Neurology","n_participants":1131,"pmid":"32333900","source_url":"https://pubmed.ncbi.nlm.nih.gov/32333900/","study_design":"longitudinal study","title":"Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts","title_match":false,"year":2020},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/association-between-csf-biomarkers-and-incipient-alzheimer-s-disease-16488378","doi":"10.1016/s1474-4422(06)70355-6","journal":"The Lancet. Neurology","n_participants":null,"pmid":"16488378","source_url":"https://pubmed.ncbi.nlm.nih.gov/16488378/","study_design":null,"title":"Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study","title_match":false,"year":2006},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/plasma-p-tau181-in-alzheimer-s-disease-relationship-to-other-32123385","doi":"10.1038/s41591-020-0755-1","journal":"Nature medicine","n_participants":589,"pmid":"32123385","source_url":"https://pubmed.ncbi.nlm.nih.gov/32123385/","study_design":null,"title":"Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia","title_match":true,"year":2020},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/inverse-relation-between-in-vivo-amyloid-imaging-load-and-16372280","doi":"10.1002/ana.20730","journal":"Annals of neurology","n_participants":null,"pmid":"16372280","source_url":"https://pubmed.ncbi.nlm.nih.gov/16372280/","study_design":null,"title":"Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans","title_match":false,"year":2006},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/plasma-phospholipids-identify-antecedent-memory-impairment-in-older-24608097","doi":"10.1038/nm.3466","journal":"Nature medicine","n_participants":null,"pmid":"24608097","source_url":"https://pubmed.ncbi.nlm.nih.gov/24608097/","study_design":null,"title":"Plasma phospholipids identify antecedent memory impairment in older adults","title_match":false,"year":2014},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/plasma-p-tau231-a-new-biomarker-for-incipient-alzheimer-s-disease-33585983","doi":"10.1007/s00401-021-02275-6","journal":"Acta neuropathologica","n_participants":588,"pmid":"33585983","source_url":"https://pubmed.ncbi.nlm.nih.gov/33585983/","study_design":null,"title":"Plasma p-tau231: a new biomarker for incipient Alzheimer's disease pathology","title_match":true,"year":2021},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-217-and-phosphorylated-tau-181-as-34418401","doi":"10.1016/s1474-4422(21)00214-3","journal":"The Lancet. Neurology","n_participants":15,"pmid":"34418401","source_url":"https://pubmed.ncbi.nlm.nih.gov/34418401/","study_design":null,"title":"Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study","title_match":false,"year":2021},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/head-to-head-comparison-of-10-plasma-phospho-tau-assays-in-prodromal-36087307","doi":"10.1093/brain/awac333","journal":"Brain : a journal of neurology","n_participants":135,"pmid":"36087307","source_url":"https://pubmed.ncbi.nlm.nih.gov/36087307/","study_design":null,"title":"Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/advantages-and-disadvantages-of-the-use-of-the-csf-amyloid-a-42-40-31010420","doi":"10.1186/s13195-019-0485-0","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"31010420","source_url":"https://pubmed.ncbi.nlm.nih.gov/31010420/","study_design":null,"title":"Advantages and disadvantages of the use of the CSF Amyloid \u03b2 (A\u03b2) 42/40 ratio in the diagnosis of Alzheimer's Disease","title_match":false,"year":2019},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-for-alzheimer-s-disease-in-clinical-practice-and-37202517","doi":"10.1038/s43587-023-00403-3","journal":"Nature aging","n_participants":null,"pmid":"37202517","source_url":"https://pubmed.ncbi.nlm.nih.gov/37202517/","study_design":"longitudinal study","title":"Blood biomarkers for Alzheimer's disease in clinical practice and trials","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-and-cerebrospinal-fluid-levels-of-amyloid-beta-proteins-1-40-10634455","doi":"10.1001/archneur.57.1.100","journal":"Archives of neurology","n_participants":78,"pmid":"10634455","source_url":"https://pubmed.ncbi.nlm.nih.gov/10634455/","study_design":null,"title":"Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease","title_match":false,"year":2000},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/core-candidate-neurochemical-and-imaging-biomarkers-of-alzheimer-s-18631949","doi":"10.1016/j.jalz.2007.08.006","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"18631949","source_url":"https://pubmed.ncbi.nlm.nih.gov/18631949/","study_design":null,"title":"Core candidate neurochemical and imaging biomarkers of Alzheimer's disease","title_match":false,"year":2008},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/plasma-p-tau181-p-tau217-and-other-blood-based-alzheimer-s-disease-33580742","doi":"10.1002/alz.12301","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"33580742","source_url":"https://pubmed.ncbi.nlm.nih.gov/33580742/","study_design":null,"title":"Plasma p-tau181, p-tau217, and other blood-based Alzheimer's disease biomarkers in a multi-ethnic, community study","title_match":true,"year":2021},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/proteome-based-plasma-biomarkers-for-alzheimer-s-disease-17071923","doi":"10.1093/brain/awl279","journal":"Brain : a journal of neurology","n_participants":50,"pmid":"17071923","source_url":"https://pubmed.ncbi.nlm.nih.gov/17071923/","study_design":"case-control study","title":"Proteome-based plasma biomarkers for Alzheimer's disease","title_match":true,"year":2006},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/recommendations-for-the-diagnosis-and-management-of-alzheimer-s-17222085","doi":"10.1111/j.1468-1331.2006.01605.x","journal":"European journal of neurology","n_participants":null,"pmid":"17222085","source_url":"https://pubmed.ncbi.nlm.nih.gov/17222085/","study_design":"meta-analysis","title":"Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline","title_match":false,"year":2007},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/efns-guidelines-for-the-diagnosis-and-management-of-alzheimer-s-20831773","doi":"10.1111/j.1468-1331.2010.03040.x","journal":"European journal of neurology","n_participants":null,"pmid":"20831773","source_url":"https://pubmed.ncbi.nlm.nih.gov/20831773/","study_design":"meta-analysis","title":"EFNS guidelines for the diagnosis and management of Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/plasma-p-tau181-accurately-predicts-alzheimer-s-disease-pathology-at-32720099","doi":"10.1007/s00401-020-02195-x","journal":"Acta neuropathologica","n_participants":115,"pmid":"32720099","source_url":"https://pubmed.ncbi.nlm.nih.gov/32720099/","study_design":"longitudinal study","title":"Plasma p-tau181 accurately predicts Alzheimer's disease pathology at least 8\u00a0years prior to post-mortem and improves the clinical characterisation of cognitive decline","title_match":true,"year":2020},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/diagnostic-performance-and-prediction-of-clinical-progression-of-33106600","doi":"10.1038/s41380-020-00923-z","journal":"Molecular psychiatry","n_participants":1000,"pmid":"33106600","source_url":"https://pubmed.ncbi.nlm.nih.gov/33106600/","study_design":"longitudinal study","title":"Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging Initiative","title_match":false,"year":2021},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-as-a-clinical-biological-construct-an-international-39483064","doi":"10.1001/jamaneurol.2024.3770","journal":"JAMA neurology","n_participants":null,"pmid":"39483064","source_url":"https://pubmed.ncbi.nlm.nih.gov/39483064/","study_design":null,"title":"Alzheimer Disease as a Clinical-Biological Construct-An International Working Group Recommendation","title_match":false,"year":2024},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/measurement-of-phosphorylated-tau-epitopes-in-the-differential-14706948","doi":"10.1001/archpsyc.61.1.95","journal":"Archives of general psychiatry","n_participants":206,"pmid":"14706948","source_url":"https://pubmed.ncbi.nlm.nih.gov/14706948/","study_design":"cross-sectional","title":"Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study","title_match":false,"year":2004},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/dysfunctionally-phosphorylated-type-1-insulin-receptor-substrate-in-25342129","doi":"10.1096/fj.14-262048","journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","n_participants":26,"pmid":"25342129","source_url":"https://pubmed.ncbi.nlm.nih.gov/25342129/","study_design":"longitudinal study","title":"Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/glial-fibrillary-acidic-protein-in-serum-is-increased-in-alzheimer-s-30594925","doi":"10.3233/jad-180325","journal":"Journal of Alzheimer's disease : JAD","n_participants":28,"pmid":"30594925","source_url":"https://pubmed.ncbi.nlm.nih.gov/30594925/","study_design":null,"title":"Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer's Disease and Correlates with Cognitive Impairment","title_match":false,"year":2019},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/plasma-tau-neurofilament-light-chain-and-amyloid-levels-and-risk-of-32206776","doi":"10.1093/brain/awaa054","journal":"Brain : a journal of neurology","n_participants":549,"pmid":"32206776","source_url":"https://pubmed.ncbi.nlm.nih.gov/32206776/","study_design":null,"title":"Plasma tau, neurofilament light chain and amyloid-\u03b2 levels and risk of dementia; a population-based cohort study","title_match":false,"year":2020},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-tau-beta-amyloid-42-ratio-as-a-prediction-of-17210801","doi":"10.1001/archneur.64.3.noc60123","journal":"Archives of neurology","n_participants":139,"pmid":"17210801","source_url":"https://pubmed.ncbi.nlm.nih.gov/17210801/","study_design":"longitudinal study","title":"Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults","title_match":false,"year":2007},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/longitudinal-change-in-csf-biomarkers-in-autosomal-dominant-alzheimer-24598588","doi":"10.1126/scitranslmed.3007901","journal":"Science translational medicine","n_participants":null,"pmid":"24598588","source_url":"https://pubmed.ncbi.nlm.nih.gov/24598588/","study_design":"cross-sectional","title":"Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/amyloid-imaging-and-csf-biomarkers-in-predicting-cognitive-impairment-23576620","doi":"10.1212/wnl.0b013e3182918ca6","journal":"Neurology","n_participants":201,"pmid":"23576620","source_url":"https://pubmed.ncbi.nlm.nih.gov/23576620/","study_design":"longitudinal study","title":"Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later","title_match":false,"year":2013},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/diagnostic-performance-of-ro948-f-18-tau-positron-emission-tomography-32391858","doi":"10.1001/jamaneurol.2020.0989","journal":"JAMA neurology","n_participants":257,"pmid":"32391858","source_url":"https://pubmed.ncbi.nlm.nih.gov/32391858/","study_design":"cross-sectional","title":"Diagnostic Performance of RO948 F 18 Tau Positron Emission Tomography in the Differentiation of Alzheimer Disease From Other Neurodegenerative Disorders","title_match":false,"year":2020},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/comparison-of-analytical-platforms-for-cerebrospinal-fluid-measures-21555603","doi":"10.1001/archneurol.2011.105","journal":"Archives of neurology","n_participants":103,"pmid":"21555603","source_url":"https://pubmed.ncbi.nlm.nih.gov/21555603/","study_design":null,"title":"Comparison of analytical platforms for cerebrospinal fluid measures of \u03b2-amyloid 1-42, total tau, and p-tau181 for identifying Alzheimer disease amyloid plaque pathology","title_match":true,"year":2011},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/visinin-like-protein-1-diagnostic-and-prognostic-biomarker-in-21823155","doi":"10.1002/ana.22448","journal":"Annals of neurology","n_participants":211,"pmid":"21823155","source_url":"https://pubmed.ncbi.nlm.nih.gov/21823155/","study_design":null,"title":"Visinin-like protein-1: diagnostic and prognostic biomarker in Alzheimer disease","title_match":false,"year":2011},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-levels-and-the-risk-of-ad-in-normal-subjects-in-the-18401021","doi":"10.1212/01.wnl.0000306696.82017.66","journal":"Neurology","n_participants":55,"pmid":"18401021","source_url":"https://pubmed.ncbi.nlm.nih.gov/18401021/","study_design":"cross-sectional","title":"Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study","title_match":true,"year":2008},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-p-tau217-performs-better-than-p-tau181-as-a-32246036","doi":"10.1038/s41467-020-15436-0","journal":"Nature communications","n_participants":194,"pmid":"32246036","source_url":"https://pubmed.ncbi.nlm.nih.gov/32246036/","study_design":"longitudinal study","title":"Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer's disease","title_match":true,"year":2020},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-phospho-tau-in-alzheimer-s-disease-towards-diagnostic-and-36927491","doi":"10.1186/s13024-023-00605-8","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"36927491","source_url":"https://pubmed.ncbi.nlm.nih.gov/36927491/","study_design":null,"title":"Plasma phospho-tau in Alzheimer's disease: towards diagnostic and therapeutic trial applications","title_match":false,"year":2023},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/time-course-of-phosphorylated-tau181-in-blood-across-the-alzheimer-s-33257949","doi":"10.1093/brain/awaa399","journal":"Brain : a journal of neurology","n_participants":1067,"pmid":"33257949","source_url":"https://pubmed.ncbi.nlm.nih.gov/33257949/","study_design":"prospective cohort","title":"Time course of phosphorylated-tau181 in blood across the Alzheimer's disease spectrum","title_match":false,"year":2021},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/i-c9orf72-i-poly-gr-aggregation-induces-tdp-43-proteinopathy-32878979","doi":"10.1126/scitranslmed.abb3774","journal":"Science translational medicine","n_participants":null,"pmid":"32878979","source_url":"https://pubmed.ncbi.nlm.nih.gov/32878979/","study_design":null,"title":"C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy","title_match":false,"year":2020},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/oxidant-antioxidant-imbalance-in-alzheimer-s-disease-therapeutic-and-29636850","doi":"10.1155/2018/6435861","journal":"Oxidative medicine and cellular longevity","n_participants":null,"pmid":"29636850","source_url":"https://pubmed.ncbi.nlm.nih.gov/29636850/","study_design":null,"title":"Oxidant/Antioxidant Imbalance in Alzheimer's Disease: Therapeutic and Diagnostic Prospects","title_match":false,"year":2018},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/consumption-of-green-tea-but-not-black-tea-or-coffee-is-associated-24828424","doi":"10.1371/journal.pone.0096013","journal":"PloS one","n_participants":723,"pmid":"24828424","source_url":"https://pubmed.ncbi.nlm.nih.gov/24828424/","study_design":null,"title":"Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline","title_match":false,"year":2014},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/the-link-between-obstructive-sleep-apnea-and-neurocognitive-35913462","doi":"10.1513/annalsats.202205-380st","journal":"Annals of the American Thoracic Society","n_participants":null,"pmid":"35913462","source_url":"https://pubmed.ncbi.nlm.nih.gov/35913462/","study_design":"longitudinal study","title":"The Link between Obstructive Sleep Apnea and Neurocognitive Impairment: An Official American Thoracic Society Workshop Report","title_match":false,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/ethnic-differences-in-beliefs-regarding-alzheimer-disease-among-20104051","doi":"10.1097/jgp.0b013e3181ad4f3c","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":null,"pmid":"20104051","source_url":"https://pubmed.ncbi.nlm.nih.gov/20104051/","study_design":null,"title":"Ethnic differences in beliefs regarding Alzheimer disease among dementia family caregivers","title_match":false,"year":2009},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/characterizing-plasma-nfl-in-a-community-dwelling-multi-ethnic-cohort-34310015","doi":"10.1002/alz.12404","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":890,"pmid":"34310015","source_url":"https://pubmed.ncbi.nlm.nih.gov/34310015/","study_design":null,"title":"Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study","title_match":true,"year":2022},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-in-alzheimer-s-disease-and-vascular-disease-27241045","doi":"10.1038/srep26801","journal":"Scientific reports","n_participants":719,"pmid":"27241045","source_url":"https://pubmed.ncbi.nlm.nih.gov/27241045/","study_design":null,"title":"Plasma \u03b2-amyloid in Alzheimer's disease and vascular disease","title_match":false,"year":2016},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/head-to-head-comparison-of-8-plasma-amyloid-42-40-assays-in-alzheimer-34542571","doi":"10.1001/jamaneurol.2021.3180","journal":"JAMA neurology","n_participants":182,"pmid":"34542571","source_url":"https://pubmed.ncbi.nlm.nih.gov/34542571/","study_design":null,"title":"Head-to-Head Comparison of 8 Plasma Amyloid-\u03b2 42/40 Assays in Alzheimer Disease","title_match":true,"year":2021},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/ykl-40-a-novel-prognostic-fluid-biomarker-for-preclinical-alzheimer-s-21035623","doi":"10.1016/j.biopsych.2010.08.025","journal":"Biological psychiatry","n_participants":47,"pmid":"21035623","source_url":"https://pubmed.ncbi.nlm.nih.gov/21035623/","study_design":null,"title":"YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/plasma-abeta-1-40-and-abeta-1-42-and-the-risk-of-dementia-a-16857570","doi":"10.1016/s1474-4422(06)70501-4","journal":"The Lancet. Neurology","n_participants":6713,"pmid":"16857570","source_url":"https://pubmed.ncbi.nlm.nih.gov/16857570/","study_design":"cohort study","title":"Plasma Abeta(1-40) and Abeta(1-42) and the risk of dementia: a prospective case-cohort study","title_match":true,"year":2006},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/association-of-low-plasma-abeta42-abeta40-ratios-with-increased-17353377","doi":"10.1001/archneur.64.3.354","journal":"Archives of neurology","n_participants":53,"pmid":"17353377","source_url":"https://pubmed.ncbi.nlm.nih.gov/17353377/","study_design":null,"title":"Association of low plasma Abeta42/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease","title_match":true,"year":2007},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/multiplexed-immunoassay-panel-identifies-novel-csf-biomarkers-for-21526197","doi":"10.1371/journal.pone.0018850","journal":"PloS one","n_participants":null,"pmid":"21526197","source_url":"https://pubmed.ncbi.nlm.nih.gov/21526197/","study_design":null,"title":"Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis","title_match":false,"year":2011},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/a-cerebrospinal-fluid-synaptic-protein-biomarker-for-prediction-of-40164724","doi":"10.1038/s41591-025-03565-2","journal":"Nature medicine","n_participants":3397,"pmid":"40164724","source_url":"https://pubmed.ncbi.nlm.nih.gov/40164724/","study_design":"case-control study","title":"A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/a-blood-based-predictor-for-neocortical-a-burden-in-alzheimer-s-23628985","doi":"10.1038/mp.2013.40","journal":"Molecular psychiatry","n_participants":273,"pmid":"23628985","source_url":"https://pubmed.ncbi.nlm.nih.gov/23628985/","study_design":null,"title":"A blood-based predictor for neocortical A\u03b2 burden in Alzheimer's disease: results from the AIBL study","title_match":false,"year":2014},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/modifiable-risk-factors-for-dementia-and-dementia-risk-profiling-a-34635138","doi":"10.1186/s13195-021-00895-4","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"34635138","source_url":"https://pubmed.ncbi.nlm.nih.gov/34635138/","study_design":null,"title":"Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services-part 2 of 6","title_match":false,"year":2021},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/a-combination-model-of-ad-biomarkers-revealed-by-machine-learning-35668045","doi":"10.1002/alz.12700","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":411,"pmid":"35668045","source_url":"https://pubmed.ncbi.nlm.nih.gov/35668045/","study_design":null,"title":"A combination model of AD biomarkers revealed by machine learning precisely predicts Alzheimer's dementia: China Aging and Neurodegenerative Initiative (CANDI) study","title_match":false,"year":2023},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/remote-and-unsupervised-digital-memory-assessments-can-reliably-38867417","doi":"10.1002/alz.13919","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38867417","source_url":"https://pubmed.ncbi.nlm.nih.gov/38867417/","study_design":null,"title":"Remote and unsupervised digital memory assessments can reliably detect cognitive impairment in Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/global-neuropathologic-severity-of-alzheimer-s-disease-and-locus-36575455","doi":"10.1186/s13024-022-00578-0","journal":"Molecular neurodegeneration","n_participants":35,"pmid":"36575455","source_url":"https://pubmed.ncbi.nlm.nih.gov/36575455/","study_design":null,"title":"Global neuropathologic severity of Alzheimer's disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels","title_match":false,"year":2022},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/plasma-metabolic-profiles-predict-future-dementia-and-dementia-38254212","doi":"10.1186/s13195-023-01379-3","journal":"Alzheimer's research & therapy","n_participants":274160,"pmid":"38254212","source_url":"https://pubmed.ncbi.nlm.nih.gov/38254212/","study_design":"longitudinal study","title":"Plasma metabolic profiles predict future dementia and dementia subtypes: a prospective analysis of 274,160 participants","title_match":false,"year":2024},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/classifications-of-neurodegenerative-disorders-using-a-multiplex-32967146","doi":"10.3390/ijms21186914","journal":"International journal of molecular sciences","n_participants":377,"pmid":"32967146","source_url":"https://pubmed.ncbi.nlm.nih.gov/32967146/","study_design":null,"title":"Classifications of Neurodegenerative Disorders Using a Multiplex Blood Biomarkers-Based Machine Learning Model","title_match":false,"year":2020},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/serum-neuronal-exosomes-predict-and-differentiate-parkinson-s-disease-32273329","doi":"10.1136/jnnp-2019-322588","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":314,"pmid":"32273329","source_url":"https://pubmed.ncbi.nlm.nih.gov/32273329/","study_design":"cross-sectional","title":"Serum neuronal exosomes predict and differentiate Parkinson's disease from atypical parkinsonism","title_match":false,"year":2020},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/elevated-plasma-beta-amyloid-peptide-abeta-42-levels-incident-17620492","doi":"10.1001/archneur.64.7.1007","journal":"Archives of neurology","n_participants":204,"pmid":"17620492","source_url":"https://pubmed.ncbi.nlm.nih.gov/17620492/","study_design":"cohort study","title":"Elevated plasma beta-amyloid peptide Abeta(42) levels, incident dementia, and mortality in Down syndrome","title_match":false,"year":2007},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/change-in-plasma-a-peptides-and-onset-of-dementia-in-adults-with-down-21041786","doi":"10.1212/wnl.0b013e3181fb448b","journal":"Neurology","n_participants":225,"pmid":"21041786","source_url":"https://pubmed.ncbi.nlm.nih.gov/21041786/","study_design":null,"title":"Change in plasma A\u00df peptides and onset of dementia in adults with Down syndrome","title_match":false,"year":2010},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/quantitative-proteomics-analysis-of-maternal-plasma-in-down-syndrome-19902006","doi":"10.1155/2010/952047","journal":"Journal of biomedicine & biotechnology","n_participants":null,"pmid":"19902006","source_url":"https://pubmed.ncbi.nlm.nih.gov/19902006/","study_design":null,"title":"Quantitative proteomics analysis of maternal plasma in Down syndrome pregnancies using isobaric tagging reagent (iTRAQ)","title_match":false,"year":2010},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/increased-amyloid-beta-protein-levels-in-children-and-adolescents-17275850","doi":"10.1016/j.jns.2006.12.010","journal":"Journal of the neurological sciences","n_participants":35,"pmid":"17275850","source_url":"https://pubmed.ncbi.nlm.nih.gov/17275850/","study_design":null,"title":"Increased amyloid beta protein levels in children and adolescents with Down syndrome","title_match":false,"year":2007},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-beta-protein-1-42-levels-are-increased-in-old-down-12757888","doi":"10.1016/s0304-3940(03)00275-1","journal":"Neuroscience letters","n_participants":null,"pmid":"12757888","source_url":"https://pubmed.ncbi.nlm.nih.gov/12757888/","study_design":null,"title":"Plasma amyloid beta protein 1-42 levels are increased in old Down Syndrome but not in young Down Syndrome","title_match":true,"year":2003},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/serum-beta-synuclein-is-higher-in-down-syndrome-and-precedes-rise-of-35340050","doi":"10.1002/ana.26360","journal":"Annals of neurology","n_participants":14,"pmid":"35340050","source_url":"https://pubmed.ncbi.nlm.nih.gov/35340050/","study_design":"case-control study","title":"Serum Beta-Synuclein Is Higher in Down Syndrome and Precedes Rise of pTau181","title_match":true,"year":2022},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/plasma-p-tau212-as-a-biomarker-of-sporadic-and-down-syndrome-40275833","doi":"10.1002/alz.70172","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":245,"pmid":"40275833","source_url":"https://pubmed.ncbi.nlm.nih.gov/40275833/","study_design":null,"title":"Plasma p-tau212 as a biomarker of sporadic and Down syndrome Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-co-pathology-in-down-syndrome-associated-alzheimer-s-40528443","doi":"10.1002/alz.70342","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":270,"pmid":"40528443","source_url":"https://pubmed.ncbi.nlm.nih.gov/40528443/","study_design":null,"title":"Alpha-synuclein co-pathology in Down syndrome-associated Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/the-tau-biomarker-cascade-is-condensed-in-down-syndrome-compared-with-41240365","doi":"10.1093/brain/awaf428","journal":"Brain : a journal of neurology","n_participants":198,"pmid":"41240365","source_url":"https://pubmed.ncbi.nlm.nih.gov/41240365/","study_design":"longitudinal study","title":"The tau biomarker cascade is condensed in Down syndrome compared with sporadic Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/the-effects-of-mosaicism-on-biological-and-clinical-markers-of-39500037","doi":"10.1016/j.ebiom.2024.105433","journal":"EBioMedicine","n_participants":357,"pmid":"39500037","source_url":"https://pubmed.ncbi.nlm.nih.gov/39500037/","study_design":"longitudinal study","title":"The effects of mosaicism on biological and clinical markers of Alzheimer's disease in adults with Down syndrome","title_match":false,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/imaging-and-plasma-biomarkers-for-pathological-accumulation-in-down-41205623","doi":"10.1093/brain/awaf418","journal":"Brain : a journal of neurology","n_participants":328,"pmid":"41205623","source_url":"https://pubmed.ncbi.nlm.nih.gov/41205623/","study_design":"longitudinal study","title":"Imaging and plasma biomarkers for pathological accumulation in Down syndrome","title_match":true,"year":2026},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/association-of-plasma-neurofilament-light-chain-with-microstructural-39583646","doi":"10.1002/dad2.70023","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"39583646","source_url":"https://pubmed.ncbi.nlm.nih.gov/39583646/","study_design":"cross-sectional","title":"Association of plasma neurofilament light chain with microstructural white matter changes in Down syndrome","title_match":false,"year":2024},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/inflammation-associated-with-obesity-aging-and-amyloid-burden-in-42244445","doi":"10.1002/oby.70229","journal":"Obesity (Silver Spring, Md.)","n_participants":null,"pmid":"42244445","source_url":"https://pubmed.ncbi.nlm.nih.gov/42244445/","study_design":null,"title":"Inflammation Associated With Obesity, Aging, and Amyloid Burden in Adults With Down Syndrome","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/diagnostic-performance-of-plasma-a-sub-1-42-sub-a-sub-1-40-sub-and-d99e2e19","doi":"10.1101/2023.04.20.23288852","journal":"medRxiv","n_participants":136,"pmid":null,"source_url":"https://doi.org/10.1101/2023.04.20.23288852","study_design":null,"title":"Diagnostic performance of plasma A\u03b2 1-42 , A\u03b2 1-40 and pTau 181 in the LUMIPULSE automated platform for the detection of Alzheimer disease","title_match":true,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/changes-in-serum-synuclein-precede-blood-biomarkers-of-alzheimer-42768868","doi":"10.1002/alz.71860","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":131,"pmid":"42768868","source_url":"https://pubmed.ncbi.nlm.nih.gov/42768868/","study_design":"cross-sectional","title":"Changes in serum \u03b2-synuclein precede blood biomarkers of Alzheimer pathology in Down syndrome","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/cerebrovascular-disease-drives-alzheimer-plasma-biomarker-e40cb7d2","doi":"10.1101/2023.11.28.23298693","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1101/2023.11.28.23298693","study_design":null,"title":"Cerebrovascular disease drives Alzheimer plasma biomarker concentrations in adults with Down syndrome","title_match":true,"year":2023},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/diagnostic-value-of-plasma-phosphorylated-tau181-in-alzheimer-s-32123386","doi":"10.1038/s41591-020-0762-2","journal":"Nature medicine","n_participants":null,"pmid":"32123386","source_url":"https://pubmed.ncbi.nlm.nih.gov/32123386/","study_design":null,"title":"Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration","title_match":false,"year":2020},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/a-multicentre-validation-study-of-the-diagnostic-value-of-plasma-34099648","doi":"10.1038/s41467-021-23620-z","journal":"Nature communications","n_participants":805,"pmid":"34099648","source_url":"https://pubmed.ncbi.nlm.nih.gov/34099648/","study_design":null,"title":"A multicentre validation study of the diagnostic value of plasma neurofilament light","title_match":false,"year":2021},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/serum-neurofilament-light-chain-protein-is-a-measure-of-disease-27581216","doi":"10.1212/wnl.0000000000003154","journal":"Neurology","n_participants":74,"pmid":"27581216","source_url":"https://pubmed.ncbi.nlm.nih.gov/27581216/","study_design":null,"title":"Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia","title_match":false,"year":2016},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/prediction-of-future-alzheimer-s-disease-dementia-using-plasma-34031605","doi":"10.1038/s41591-021-01348-z","journal":"Nature medicine","n_participants":340,"pmid":"34031605","source_url":"https://pubmed.ncbi.nlm.nih.gov/34031605/","study_design":null,"title":"Prediction of future Alzheimer's disease dementia using plasma phospho-tau combined with other accessible measures","title_match":false,"year":2021},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/preserved-cognition-in-patients-with-early-alzheimer-disease-and-16286438","doi":"10.1176/appi.ajgp.13.11.950","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":20,"pmid":"16286438","source_url":"https://pubmed.ncbi.nlm.nih.gov/16286438/","study_design":null,"title":"Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study","title_match":false,"year":2005},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/longitudinal-plasma-p-tau217-is-increased-in-early-stages-of-33068398","doi":"10.1093/brain/awaa286","journal":"Brain : a journal of neurology","n_participants":62,"pmid":"33068398","source_url":"https://pubmed.ncbi.nlm.nih.gov/33068398/","study_design":"longitudinal study","title":"Longitudinal plasma p-tau217 is increased in early stages of Alzheimer's disease","title_match":true,"year":2020},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/increased-soluble-trem2-in-cerebrospinal-fluid-is-associated-with-31462511","doi":"10.1126/scitranslmed.aav6221","journal":"Science translational medicine","n_participants":null,"pmid":"31462511","source_url":"https://pubmed.ncbi.nlm.nih.gov/31462511/","study_design":null,"title":"Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-as-prescreener-for-the-earliest-alzheimer-pathological-30196548","doi":"10.1002/ana.25334","journal":"Annals of neurology","n_participants":248,"pmid":"30196548","source_url":"https://pubmed.ncbi.nlm.nih.gov/30196548/","study_design":null,"title":"Plasma Amyloid as Prescreener for the Earliest Alzheimer Pathological Changes","title_match":true,"year":2018},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/update-on-the-biomarker-core-of-the-alzheimer-s-disease-neuroimaging-20451871","doi":"10.1016/j.jalz.2010.03.008","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"20451871","source_url":"https://pubmed.ncbi.nlm.nih.gov/20451871/","study_design":null,"title":"Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects","title_match":false,"year":2010},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/evaluation-of-plasma-abeta-40-and-abeta-42-as-predictors-of-18486992","doi":"10.1016/j.neurobiolaging.2008.03.027","journal":"Neurobiology of aging","n_participants":null,"pmid":"18486992","source_url":"https://pubmed.ncbi.nlm.nih.gov/18486992/","study_design":null,"title":"Evaluation of plasma Abeta(40) and Abeta(42) as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment","title_match":true,"year":2010},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/inflammatory-biomarkers-in-alzheimer-s-disease-plasma-31047856","doi":"10.1016/j.jalz.2019.03.007","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"31047856","source_url":"https://pubmed.ncbi.nlm.nih.gov/31047856/","study_design":null,"title":"Inflammatory biomarkers in Alzheimer's disease plasma","title_match":false,"year":2019},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/fifteen-years-of-the-australian-imaging-biomarkers-and-lifestyle-aibl-34368630","doi":"10.3233/adr-210005","journal":"Journal of Alzheimer's disease reports","n_participants":1112,"pmid":"34368630","source_url":"https://pubmed.ncbi.nlm.nih.gov/34368630/","study_design":"cohort study","title":"Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/plasma-proteins-predict-conversion-to-dementia-from-prodromal-disease-25012867","doi":"10.1016/j.jalz.2014.05.1749","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1148,"pmid":"25012867","source_url":"https://pubmed.ncbi.nlm.nih.gov/25012867/","study_design":null,"title":"Plasma proteins predict conversion to dementia from prodromal disease","title_match":false,"year":2014},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/factors-affecting-a-plasma-levels-and-their-utility-as-biomarkers-in-21805181","doi":"10.1007/s00401-011-0861-8","journal":"Acta neuropathologica","n_participants":715,"pmid":"21805181","source_url":"https://pubmed.ncbi.nlm.nih.gov/21805181/","study_design":"longitudinal study","title":"Factors affecting A\u03b2 plasma levels and their utility as biomarkers in ADNI","title_match":false,"year":2011},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/predicting-progression-from-mild-cognitive-impairment-to-alzheimer-s-26901338","doi":"10.1371/journal.pone.0138866","journal":"PloS one","n_participants":139,"pmid":"26901338","source_url":"https://pubmed.ncbi.nlm.nih.gov/26901338/","study_design":null,"title":"Predicting Progression from Mild Cognitive Impairment to Alzheimer's Dementia Using Clinical, MRI, and Plasma Biomarkers via Probabilistic Pattern Classification","title_match":true,"year":2016},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/mri-and-csf-studies-in-the-early-diagnosis-of-alzheimer-s-disease-15324364","doi":"10.1111/j.1365-2796.2004.01381.x","journal":"Journal of internal medicine","n_participants":null,"pmid":"15324364","source_url":"https://pubmed.ncbi.nlm.nih.gov/15324364/","study_design":"cross-sectional","title":"MRI and CSF studies in the early diagnosis of Alzheimer's disease","title_match":false,"year":2004},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/plasma-ceramides-are-altered-in-mild-cognitive-impairment-and-predict-20813340","doi":"10.1016/j.jalz.2010.03.014","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":25,"pmid":"20813340","source_url":"https://pubmed.ncbi.nlm.nih.gov/20813340/","study_design":"cross-sectional","title":"Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss","title_match":false,"year":2010},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/identification-and-validation-of-novel-cerebrospinal-fluid-biomarkers-21264269","doi":"10.1371/journal.pone.0016032","journal":"PloS one","n_participants":24,"pmid":"21264269","source_url":"https://pubmed.ncbi.nlm.nih.gov/21264269/","study_design":null,"title":"Identification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer's disease","title_match":false,"year":2011},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/plasma-a42-40-ratio-detects-early-stages-of-alzheimer-s-disease-and-30569084","doi":"10.14283/jpad.2018.41","journal":"The journal of prevention of Alzheimer's disease","n_participants":145,"pmid":"30569084","source_url":"https://pubmed.ncbi.nlm.nih.gov/30569084/","study_design":null,"title":"Plasma A\u03b242/40 Ratio Detects Early Stages of Alzheimer's Disease and Correlates with CSF and Neuroimaging Biomarkers in the AB255 Study","title_match":true,"year":2019},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-profiled-by-fluid-and-imaging-markers-tau-pet-34593971","doi":"10.1038/s41380-021-01263-2","journal":"Molecular psychiatry","n_participants":282,"pmid":"34593971","source_url":"https://pubmed.ncbi.nlm.nih.gov/34593971/","study_design":"longitudinal study","title":"Alzheimer's disease profiled by fluid and imaging markers: tau PET best predicts cognitive decline","title_match":false,"year":2021},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/tau-pet-correlates-with-different-alzheimer-s-disease-related-34254442","doi":"10.15252/emmm.202114398","journal":"EMBO molecular medicine","n_participants":400,"pmid":"34254442","source_url":"https://pubmed.ncbi.nlm.nih.gov/34254442/","study_design":null,"title":"Tau PET correlates with different Alzheimer's disease-related features compared to CSF and plasma p-tau biomarkers","title_match":true,"year":2021},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/diagnostic-and-prognostic-performance-to-detect-alzheimer-s-disease-35568889","doi":"10.1186/s13195-022-01005-8","journal":"Alzheimer's research & therapy","n_participants":25,"pmid":"35568889","source_url":"https://pubmed.ncbi.nlm.nih.gov/35568889/","study_design":null,"title":"Diagnostic and prognostic performance to detect Alzheimer's disease and clinical progression of a novel assay for plasma p-tau217","title_match":true,"year":2022},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/effects-of-intensive-lifestyle-changes-on-the-progression-of-mild-38849944","doi":"10.1186/s13195-024-01482-z","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"38849944","source_url":"https://pubmed.ncbi.nlm.nih.gov/38849944/","study_design":"clinical trial","title":"Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: a randomized, controlled clinical trial","title_match":false,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/harnessing-peripheral-dna-methylation-differences-in-the-alzheimer-s-32539856","doi":"10.1186/s13148-020-00864-y","journal":"Clinical epigenetics","n_participants":653,"pmid":"32539856","source_url":"https://pubmed.ncbi.nlm.nih.gov/32539856/","study_design":"longitudinal study","title":"Harnessing peripheral DNA methylation differences in the Alzheimer's Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease","title_match":false,"year":2020},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/associations-between-biomarkers-and-age-in-the-presenilin-1-e280a-25580592","doi":"10.1001/jamaneurol.2014.3314","journal":"JAMA neurology","n_participants":null,"pmid":"25580592","source_url":"https://pubmed.ncbi.nlm.nih.gov/25580592/","study_design":"cross-sectional","title":"Associations between biomarkers and age in the presenilin 1 E280A autosomal dominant Alzheimer disease kindred: a cross-sectional study","title_match":false,"year":2015},{"alzhub_score":78,"alzhub_url":"https://alzhub.org/study/plasma-gfap-is-an-early-marker-of-amyloid-but-not-tau-pathology-in-34259835","doi":"10.1093/brain/awab223","journal":"Brain : a journal of neurology","n_participants":75,"pmid":"34259835","source_url":"https://pubmed.ncbi.nlm.nih.gov/34259835/","study_design":"longitudinal study","title":"Plasma GFAP is an early marker of amyloid-\u03b2 but not tau pathology in Alzheimer's disease","title_match":true,"year":2021},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/plcg2-protective-variant-p-p522r-modulates-tau-pathology-and-disease-32166339","doi":"10.1007/s00401-020-02138-6","journal":"Acta neuropathologica","n_participants":10097,"pmid":"32166339","source_url":"https://pubmed.ncbi.nlm.nih.gov/32166339/","study_design":"longitudinal study","title":"PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment","title_match":false,"year":2020},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/neuroinflammatory-biomarkers-in-alzheimer-s-disease-from-39596011","doi":"10.3390/ijms252211941","journal":"International journal of molecular sciences","n_participants":null,"pmid":"39596011","source_url":"https://pubmed.ncbi.nlm.nih.gov/39596011/","study_design":null,"title":"Neuroinflammatory Biomarkers in Alzheimer's Disease: From Pathophysiology to Clinical Implications","title_match":false,"year":2024},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/strem2-is-associated-with-amyloid-related-p-tau-increases-and-glucose-36620941","doi":"10.15252/emmm.202216987","journal":"EMBO molecular medicine","n_participants":70,"pmid":"36620941","source_url":"https://pubmed.ncbi.nlm.nih.gov/36620941/","study_design":"cross-sectional","title":"sTREM2 is associated with amyloid-related p-tau increases and glucose hypermetabolism in Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-and-plasma-biomarkers-in-alzheimer-disease-20157306","doi":"10.1038/nrneurol.2010.4","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"20157306","source_url":"https://pubmed.ncbi.nlm.nih.gov/20157306/","study_design":null,"title":"Cerebrospinal fluid and plasma biomarkers in Alzheimer disease","title_match":true,"year":2010},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/correlation-of-cerebrospinal-fluid-levels-of-tau-protein-15883264","doi":"10.1001/archneur.62.5.770","journal":"Archives of neurology","n_participants":22,"pmid":"15883264","source_url":"https://pubmed.ncbi.nlm.nih.gov/15883264/","study_design":null,"title":"Correlation of cerebrospinal fluid levels of tau protein phosphorylated at threonine 231 with rates of hippocampal atrophy in Alzheimer disease","title_match":false,"year":2005},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/combined-csf-tau-p-tau181-and-amyloid-beta-38-40-42-for-diagnosing-19142572","doi":"10.1007/s00702-008-0177-6","journal":"Journal of neural transmission (Vienna, Austria : 1996)","n_participants":44,"pmid":"19142572","source_url":"https://pubmed.ncbi.nlm.nih.gov/19142572/","study_design":null,"title":"Combined CSF tau, p-tau181 and amyloid-beta 38/40/42 for diagnosing Alzheimer's disease","title_match":true,"year":2009},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/reduced-csf-p-tau181-to-tau-ratio-is-a-biomarker-for-ftld-tdp-24174584","doi":"10.1212/01.wnl.0000436625.63650.27","journal":"Neurology","n_participants":30,"pmid":"24174584","source_url":"https://pubmed.ncbi.nlm.nih.gov/24174584/","study_design":null,"title":"Reduced CSF p-Tau181 to Tau ratio is a biomarker for FTLD-TDP","title_match":true,"year":2013},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/association-of-plasma-p-tau181-and-p-tau231-concentrations-with-34807233","doi":"10.1001/jamaneurol.2021.4222","journal":"JAMA neurology","n_participants":371,"pmid":"34807233","source_url":"https://pubmed.ncbi.nlm.nih.gov/34807233/","study_design":"cohort study","title":"Association of Plasma p-tau181 and p-tau231 Concentrations With Cognitive Decline in Patients With Probable Dementia With Lewy Bodies","title_match":true,"year":2022},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-at-threonine-181-and-neuropsychiatric-36323521","doi":"10.1212/wnl.0000000000201517","journal":"Neurology","n_participants":571,"pmid":"36323521","source_url":"https://pubmed.ncbi.nlm.nih.gov/36323521/","study_design":"cross-sectional","title":"Plasma Phosphorylated Tau at Threonine 181 and Neuropsychiatric Symptoms in Preclinical and Prodromal Alzheimer Disease","title_match":false,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/plasma-a42-and-total-tau-predict-cognitive-decline-in-amnestic-mild-31562355","doi":"10.1038/s41598-019-50315-9","journal":"Scientific reports","n_participants":22,"pmid":"31562355","source_url":"https://pubmed.ncbi.nlm.nih.gov/31562355/","study_design":null,"title":"Plasma A\u03b242 and Total Tau Predict Cognitive Decline in Amnestic Mild Cognitive Impairment","title_match":true,"year":2019},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/csf-biomarkers-in-posterior-cortical-atrophy-21525425","doi":"10.1212/wnl.0b013e31821ccc98","journal":"Neurology","n_participants":22,"pmid":"21525425","source_url":"https://pubmed.ncbi.nlm.nih.gov/21525425/","study_design":null,"title":"CSF biomarkers in posterior cortical atrophy","title_match":false,"year":2011},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-tau-and-beta-amyloid-in-alzheimer-patients-16085339","doi":"10.1016/j.neurobiolaging.2005.06.005","journal":"Neurobiology of aging","n_participants":219,"pmid":"16085339","source_url":"https://pubmed.ncbi.nlm.nih.gov/16085339/","study_design":null,"title":"Cerebrospinal fluid tau and beta-amyloid in Alzheimer patients, disease controls and an age-matched random sample","title_match":false,"year":2006},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/serum-interleukin-10-levels-correlate-with-cerebrospinal-fluid-28719891","doi":"10.1159/000474940","journal":"Neuro-degenerative diseases","n_participants":27,"pmid":"28719891","source_url":"https://pubmed.ncbi.nlm.nih.gov/28719891/","study_design":null,"title":"Serum Interleukin-10 Levels Correlate with Cerebrospinal Fluid Amyloid Beta Deposition in Alzheimer Disease Patients","title_match":false,"year":2017},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/accelerated-longitudinal-changes-and-ordering-of-alzheimer-disease-35925685","doi":"10.1093/brain/awac238","journal":"Brain : a journal of neurology","n_participants":2609,"pmid":"35925685","source_url":"https://pubmed.ncbi.nlm.nih.gov/35925685/","study_design":"longitudinal study","title":"Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan","title_match":false,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/plasma-p-tau181-a-sub-1-42-sub-ratio-predicts-a-pet-status-and-36447478","doi":"10.1002/dad2.12375","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"36447478","source_url":"https://pubmed.ncbi.nlm.nih.gov/36447478/","study_design":null,"title":"Plasma p-tau181/A\u03b21-42 ratio predicts A\u03b2-PET status and correlates with CSF-p-tau181/A\u03b21-42 and future cognitive decline","title_match":true,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/inverse-association-of-cortisol-serum-levels-with-t-tau-p-tau-181-and-18806919","doi":"10.1007/s00406-008-0838-3","journal":"European archives of psychiatry and clinical neuroscience","n_participants":26,"pmid":"18806919","source_url":"https://pubmed.ncbi.nlm.nih.gov/18806919/","study_design":null,"title":"Inverse association of cortisol serum levels with T-tau, P-tau 181 and P-tau 231 peptide levels and T-tau/Abeta 1-42 ratios in CSF in patients with mild Alzheimer's disease dementia","title_match":true,"year":2009},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/association-of-longitudinal-changes-in-cerebrospinal-fluid-total-tau-31825500","doi":"10.1001/jamanetworkopen.2019.17126","journal":"JAMA network open","n_participants":465,"pmid":"31825500","source_url":"https://pubmed.ncbi.nlm.nih.gov/31825500/","study_design":"cohort study","title":"Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease","title_match":false,"year":2019},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/association-of-total-tau-and-phosphorylated-tau-181-protein-levels-in-19270764","doi":null,"journal":"Journal of psychiatry & neuroscience : JPN","n_participants":null,"pmid":"19270764","source_url":"https://pubmed.ncbi.nlm.nih.gov/19270764/","study_design":null,"title":"Association of total tau and phosphorylated tau 181 protein levels in cerebrospinal fluid with cerebral atrophy in mild cognitive impairment and Alzheimer disease","title_match":false,"year":2009},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-validation-of-multifactor-model-of-plasma-a-sub-i-42-i-sub-and-32792940","doi":"10.3389/fnagi.2020.00212","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"32792940","source_url":"https://pubmed.ncbi.nlm.nih.gov/32792940/","study_design":null,"title":"The Validation of Multifactor Model of Plasma A\u03b2 42 and Total-Tau in Combination With MoCA for Diagnosing Probable Alzheimer Disease","title_match":true,"year":2020},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/csf-alzheimer-disease-biomarkers-time-varying-relationships-with-mci-36216518","doi":"10.1212/wnl.0000000000200953","journal":"Neurology","n_participants":273,"pmid":"36216518","source_url":"https://pubmed.ncbi.nlm.nih.gov/36216518/","study_design":"longitudinal study","title":"CSF Alzheimer Disease Biomarkers: Time-Varying Relationships With MCI Symptom Onset and Associations With Age, Sex, and ApoE4","title_match":false,"year":2022},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/csf-and-plasma-biomarkers-in-cerebral-amyloid-angiopathy-a-single-38869035","doi":"10.1177/23969873241260538","journal":"European stroke journal","n_participants":null,"pmid":"38869035","source_url":"https://pubmed.ncbi.nlm.nih.gov/38869035/","study_design":"systematic review","title":"CSF and plasma biomarkers in cerebral amyloid angiopathy: A single-center study and a systematic review/meta-analysis","title_match":true,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/csf-biomarkers-of-alzheimer-disease-in-patients-with-concomitant-36041863","doi":"10.1212/wnl.0000000000201202","journal":"Neurology","n_participants":61,"pmid":"36041863","source_url":"https://pubmed.ncbi.nlm.nih.gov/36041863/","study_design":null,"title":"CSF Biomarkers of Alzheimer Disease in Patients With Concomitant \u03b1-Synuclein Pathology","title_match":false,"year":2022},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/clarifying-the-association-of-csf-a-tau-bace1-and-neurogranin-with-at-39380095","doi":"10.1186/s13024-024-00755-3","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"39380095","source_url":"https://pubmed.ncbi.nlm.nih.gov/39380095/","study_design":null,"title":"Clarifying the association of CSF A\u03b2, tau, BACE1, and neurogranin with AT(N) stages in Alzheimer disease","title_match":false,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-a42-a40-and-p-tau181-predict-long-term-clinical-progression-in-36208187","doi":"10.1093/clinchem/hvac149","journal":"Clinical chemistry","n_participants":null,"pmid":"36208187","source_url":"https://pubmed.ncbi.nlm.nih.gov/36208187/","study_design":"longitudinal study","title":"Plasma A\u03b242/A\u03b240 and p-tau181 Predict Long-Term Clinical Progression in a Cohort with Amnestic Mild Cognitive Impairment","title_match":true,"year":2022},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/microglial-reactivity-correlates-with-presynaptic-loss-independent-of-38356322","doi":"10.1002/ana.26885","journal":"Annals of neurology","n_participants":65,"pmid":"38356322","source_url":"https://pubmed.ncbi.nlm.nih.gov/38356322/","study_design":"longitudinal study","title":"Microglial Reactivity Correlates with Presynaptic Loss Independent of \u03b2-Amyloid and Tau","title_match":false,"year":2024},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/prospective-associations-between-plasma-amyloid-beta-42-40-and-33336223","doi":"10.14283/jpad.2020.60","journal":"The journal of prevention of Alzheimer's disease","n_participants":477,"pmid":"33336223","source_url":"https://pubmed.ncbi.nlm.nih.gov/33336223/","study_design":null,"title":"Prospective Associations between Plasma Amyloid-Beta 42/40 and Frailty in Community-Dwelling Older Adults","title_match":true,"year":2021},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-biomarkers-for-alzheimer-disease-among-patients-40293734","doi":"10.1001/jamaneurol.2025.0693","journal":"JAMA neurology","n_participants":null,"pmid":"40293734","source_url":"https://pubmed.ncbi.nlm.nih.gov/40293734/","study_design":"cross-sectional","title":"Cerebrospinal Fluid Biomarkers for Alzheimer Disease Among Patients With Dementia","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/discordance-and-concordance-between-cerebrospinal-and-sup-18-sup-f-36266044","doi":"10.1212/wnl.0000000000201198","journal":"Neurology","n_participants":null,"pmid":"36266044","source_url":"https://pubmed.ncbi.nlm.nih.gov/36266044/","study_design":null,"title":"Discordance and Concordance Between Cerebrospinal and [18F]FDG-PET Biomarkers in Assessing Atypical and Early-Onset AD Dementia Cases","title_match":false,"year":2022},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/plasma-p-tau181-as-an-outcome-and-predictor-of-multidomain-38310892","doi":"10.1016/s2666-7568(23)00255-6","journal":"The lancet. Healthy longevity","n_participants":527,"pmid":"38310892","source_url":"https://pubmed.ncbi.nlm.nih.gov/38310892/","study_design":null,"title":"Plasma p-tau181 as an outcome and predictor of multidomain intervention effects: a secondary analysis of a randomised, controlled, dementia prevention trial","title_match":true,"year":2024},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/enhancing-alzheimer-disease-detection-using-neuropsychiatric-symptoms-40803669","doi":"10.1177/08919887251366634","journal":"Journal of geriatric psychiatry and neurology","n_participants":null,"pmid":"40803669","source_url":"https://pubmed.ncbi.nlm.nih.gov/40803669/","study_design":null,"title":"Enhancing Alzheimer Disease Detection Using Neuropsychiatric Symptoms: The Role of Mild Behavioural Impairment in the Revised NIA-AA Research Framework","title_match":false,"year":2026},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau181-outperforms-lt-sup-gt-18-lt-sup-gt-f-39447157","doi":"10.1111/ene.16255","journal":"European journal of neurology","n_participants":533,"pmid":"39447157","source_url":"https://pubmed.ncbi.nlm.nih.gov/39447157/","study_design":null,"title":"Plasma phosphorylated tau181 outperforms [18F] fluorodeoxyglucose positron emission tomography in the identification of early Alzheimer disease","title_match":false,"year":2024},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/association-of-nonmodifiable-risk-factors-with-alzheimer-disease-40239154","doi":"10.1212/wnl.0000000000213500","journal":"Neurology","n_participants":9940,"pmid":"40239154","source_url":"https://pubmed.ncbi.nlm.nih.gov/40239154/","study_design":"cohort study","title":"Association of Nonmodifiable Risk Factors With Alzheimer Disease Blood Biomarkers in Community-Dwelling Adults in the ESTHER Study","title_match":false,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/synuclein-seed-amplifications-assay-in-a-cohort-with-cognitive-40921019","doi":"10.1212/wnl.0000000000214040","journal":"Neurology","n_participants":337,"pmid":"40921019","source_url":"https://pubmed.ncbi.nlm.nih.gov/40921019/","study_design":"cohort study","title":"\u03b1-Synuclein Seed Amplifications Assay in a Cohort With Cognitive Impairment: Performance and Interactions With CSF and Plasma Biomarkers","title_match":true,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/associations-of-cerebrospinal-fluid-orexin-a-alzheimer-disease-39957622","doi":"10.1002/acn3.70009","journal":"Annals of clinical and translational neurology","n_participants":null,"pmid":"39957622","source_url":"https://pubmed.ncbi.nlm.nih.gov/39957622/","study_design":"systematic review","title":"Associations of Cerebrospinal Fluid Orexin-A, Alzheimer Disease Biomarkers, and Cognitive Performance","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-cerebrospinal-fluid-biomarkers-in-a-tertiary-38935019","doi":"10.1016/j.mayocp.2023.12.024","journal":"Mayo Clinic proceedings","n_participants":534,"pmid":"38935019","source_url":"https://pubmed.ncbi.nlm.nih.gov/38935019/","study_design":null,"title":"Alzheimer Disease Cerebrospinal Fluid Biomarkers in a Tertiary Neurology Practice","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/effect-of-neurotoxin-exposure-on-blood-biomarkers-of-37698523","doi":"10.1097/wad.0000000000000579","journal":"Alzheimer disease and associated disorders","n_participants":1516,"pmid":"37698523","source_url":"https://pubmed.ncbi.nlm.nih.gov/37698523/","study_design":null,"title":"Effect of Neurotoxin Exposure on Blood Biomarkers of Neurodegeneration and Alzheimer Disease","title_match":false,"year":2023},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/biomarkers-with-plasma-amyloid-and-tau-protein-assayed-by-35040113","doi":null,"journal":"Acta neurologica Taiwanica","n_participants":null,"pmid":"35040113","source_url":"https://pubmed.ncbi.nlm.nih.gov/35040113/","study_design":null,"title":"Biomarkers with Plasma Amyloid \u03b2 and Tau Protein Assayed by Immunomagnetic Reduction in Patients with Amnestic Mild Cognitive Impairment and Alzheimer's Disease","title_match":true,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/neurofilament-light-chain-and-alzheimer-pathology-biomarkers-in-40482625","doi":"10.1016/j.jns.2025.123562","journal":"Journal of the neurological sciences","n_participants":83,"pmid":"40482625","source_url":"https://pubmed.ncbi.nlm.nih.gov/40482625/","study_design":null,"title":"Neurofilament light chain and Alzheimer pathology biomarkers in elderly people with multiple sclerosis","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/plasma-nfl-p-tau181-and-p-tau181-a42-ratio-in-predicting-mild-40047555","doi":"10.4088/jcp.24m15558","journal":"The Journal of clinical psychiatry","n_participants":305,"pmid":"40047555","source_url":"https://pubmed.ncbi.nlm.nih.gov/40047555/","study_design":null,"title":"Plasma NfL, P-tau181, and P-tau181/A\u03b242 Ratio in Predicting Mild Behavioral Impairment in Dementia-Free Multiethnic Asian Older Adults With Mixed Pathology in a 5-Year Clinical Cohort","title_match":true,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-biomarkers-and-subjective-cognitive-decline-among-40911305","doi":"10.1001/jamanetworkopen.2025.31038","journal":"JAMA network open","n_participants":5712,"pmid":"40911305","source_url":"https://pubmed.ncbi.nlm.nih.gov/40911305/","study_design":"cross-sectional","title":"Alzheimer Disease Biomarkers and Subjective Cognitive Decline Among Hispanic and/or Latino Adults","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/dietary-patterns-and-blood-based-biomarkers-of-alzheimer-s-disease-in-40089420","doi":"10.1016/j.tjpad.2025.100124","journal":"The journal of prevention of Alzheimer's disease","n_participants":1907,"pmid":"40089420","source_url":"https://pubmed.ncbi.nlm.nih.gov/40089420/","study_design":"cross-sectional","title":"Dietary patterns and blood-based biomarkers of Alzheimer's disease in cognitively intact older adults: Findings from a population-based study","title_match":true,"year":2025},{"alzhub_score":30,"alzhub_url":"https://alzhub.org/study/supportive-csf-biomarker-evidence-to-enhance-the-national-institute-25468261","doi":"10.1016/j.ajp.2014.10.007","journal":"Asian journal of psychiatry","n_participants":12,"pmid":"25468261","source_url":"https://pubmed.ncbi.nlm.nih.gov/25468261/","study_design":null,"title":"Supportive CSF biomarker evidence to enhance the National Institute on Aging-Alzheimer's Association criteria for diagnosis of Alzheimer's type dementia--a study from Southern India","title_match":false,"year":2015},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/plasma-and-neurostructural-biomarkers-in-the-clinical-biological-40877100","doi":"10.1016/j.tjpad.2025.100331","journal":"The journal of prevention of Alzheimer's disease","n_participants":329,"pmid":"40877100","source_url":"https://pubmed.ncbi.nlm.nih.gov/40877100/","study_design":null,"title":"Plasma and neurostructural biomarkers in the clinical-biological characterization of early stages of the Alzheimer's disease continuum: findings from the Compostela Aging Study","title_match":false,"year":2026},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/stepwise-approach-to-alzheimer-s-disease-diagnosis-in-primary-care-40866545","doi":"10.1038/s41598-025-17394-3","journal":"Scientific reports","n_participants":181,"pmid":"40866545","source_url":"https://pubmed.ncbi.nlm.nih.gov/40866545/","study_design":null,"title":"Stepwise approach to alzheimer's disease diagnosis in primary care using cognitive screening, risk factors, neuroimaging and plasma biomarkers","title_match":true,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-p-tau231-and-total-tau-t-tau-as-prognostic-39637966","doi":"10.1016/j.resuscitation.2024.110450","journal":"Resuscitation","n_participants":425,"pmid":"39637966","source_url":"https://pubmed.ncbi.nlm.nih.gov/39637966/","study_design":"cohort study","title":"Plasma phosphorylated tau (p-tau231) and total tau (t-tau) as prognostic markers of neurological outcome after cardiac arrest - a multicentre study","title_match":true,"year":2025},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/new-biomarkers-for-alzheimer-s-disease-in-cerebrospinal-fluid-and-31407045","doi":"10.1007/s00115-019-0772-9","journal":"Der Nervenarzt","n_participants":null,"pmid":"31407045","source_url":"https://pubmed.ncbi.nlm.nih.gov/31407045/","study_design":null,"title":"[New biomarkers for Alzheimer's disease in cerebrospinal fluid and blood]","title_match":false,"year":2019},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-open-a-window-to-brain-pathophysiology-in-alzheimer-38818759","doi":null,"journal":"Lakartidningen","n_participants":null,"pmid":"38818759","source_url":"https://pubmed.ncbi.nlm.nih.gov/38818759/","study_design":null,"title":"[Blood biomarkers open a window to brain pathophysiology in Alzheimer's disease]","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/contingency-of-plasma-dementia-biomarkers-on-cognitive-profiles-for-41843859","doi":"10.1212/wnl.0000000000214779","journal":"Neurology","n_participants":null,"pmid":"41843859","source_url":"https://pubmed.ncbi.nlm.nih.gov/41843859/","study_design":null,"title":"Contingency of Plasma Dementia Biomarkers on Cognitive Profiles for Prognosis of Incident Dementia: The ARIC Study","title_match":false,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/cardiovascular-risk-as-a-moderator-of-the-relationship-between-plasma-41467404","doi":"10.1161/jaha.125.044438","journal":"Journal of the American Heart Association","n_participants":301,"pmid":"41467404","source_url":"https://pubmed.ncbi.nlm.nih.gov/41467404/","study_design":null,"title":"Cardiovascular Risk as a Moderator of the Relationship Between Plasma Alzheimer Disease Biomarkers and Cognitive Status","title_match":false,"year":2026},{"alzhub_score":30,"alzhub_url":"https://alzhub.org/study/news-on-blood-biomarker-based-early-diagnosis-of-the-preliminary-41197657","doi":"10.1055/a-2698-5992","journal":"Fortschritte der Neurologie-Psychiatrie","n_participants":null,"pmid":"41197657","source_url":"https://pubmed.ncbi.nlm.nih.gov/41197657/","study_design":null,"title":"[News on blood biomarker-based early diagnosis of the preliminary stages of Alzheimer's dementia]","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/prognostic-value-of-a-t-n-biomarkers-comparing-plasma-and-imaging-40910876","doi":"10.1097/rlu.0000000000006088","journal":"Clinical nuclear medicine","n_participants":null,"pmid":"40910876","source_url":"https://pubmed.ncbi.nlm.nih.gov/40910876/","study_design":"longitudinal study","title":"Prognostic Value of A/T/N Biomarkers: Comparing Plasma and Imaging Modalities in Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/associations-between-intrinsic-capacity-plasma-p-tau181-and-cognitive-40601428","doi":"10.1016/j.tjfa.2025.100064","journal":"The Journal of frailty & aging","n_participants":491,"pmid":"40601428","source_url":"https://pubmed.ncbi.nlm.nih.gov/40601428/","study_design":"cross-sectional","title":"Associations between intrinsic capacity, plasma p-tau181 and cognitive function over a 5-year follow-up among community-dwelling older adults: a secondary analysis of the MAPT Study","title_match":true,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-biomarkers-and-cognition-in-alzheimer-disease-and-40397510","doi":"10.1097/wad.0000000000000656","journal":"Alzheimer disease and associated disorders","n_participants":61,"pmid":"40397510","source_url":"https://pubmed.ncbi.nlm.nih.gov/40397510/","study_design":"cohort study","title":"Cerebrospinal Fluid Biomarkers and Cognition in Alzheimer Disease and Frontotemporal Dementia in a Memory Clinic Setting","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/cognitive-stability-among-plasma-p-tau-181-negative-individuals-a-5-40383731","doi":"10.1093/gerona/glaf113","journal":"The journals of gerontology. Series A, Biological sciences and medical sciences","n_participants":null,"pmid":"40383731","source_url":"https://pubmed.ncbi.nlm.nih.gov/40383731/","study_design":"longitudinal study","title":"Cognitive Stability Among Plasma p-tau 181 Negative Individuals: A 5-year Analysis of the Multidomain Alzheimer Prevention Trial Study","title_match":true,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/a-head-to-head-comparison-of-plasma-biomarkers-to-detect-biologically-0d19a4a8","doi":"10.1101/2024.10.26.24316176","journal":"medRxiv","n_participants":197,"pmid":null,"source_url":"https://doi.org/10.1101/2024.10.26.24316176","study_design":"cross-sectional","title":"A head-to-head comparison of plasma biomarkers to detect biologically defined Alzheimer in a memory clinic","title_match":true,"year":2024},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/clinical-significance-of-the-plasma-biomarker-panels-in-amyloid-38891795","doi":"10.3390/ijms25115607","journal":"International journal of molecular sciences","n_participants":55,"pmid":"38891795","source_url":"https://pubmed.ncbi.nlm.nih.gov/38891795/","study_design":null,"title":"Clinical Significance of the Plasma Biomarker Panels in Amyloid-Negative and Tau PET-Positive Amnestic Patients: Comparisons with Alzheimer's Disease and Unimpaired Cognitive Controls","title_match":true,"year":2024},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/lecanemab-in-symptomatic-psen1-p-met233val-early-onset-alzheimer-s-42676462","doi":"10.1002/dad2.70468","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"42676462","source_url":"https://pubmed.ncbi.nlm.nih.gov/42676462/","study_design":"longitudinal study","title":"Lecanemab in symptomatic PSEN1 p.Met233Val early-onset Alzheimer's disease: Neuroimaging safety, regional amyloid-PET dynamics, and longitudinal plasma biomarkers","title_match":true,"year":2026},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-of-alzheimer-disease-and-rates-of-global-and-domain-42593791","doi":"10.1001/jamanetworkopen.2026.28975","journal":"JAMA network open","n_participants":2008,"pmid":"42593791","source_url":"https://pubmed.ncbi.nlm.nih.gov/42593791/","study_design":"cohort study","title":"Blood Biomarkers of Alzheimer Disease and Rates of Global and Domain-Specific Cognitive Decline","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/a-phase-2b-randomized-clinical-trial-of-the-oral-p38-inhibitor-9c23dcf2","doi":"10.21203/rs.3.rs-10623740/v1","journal":"Research Square","n_participants":159,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10623740/v1","study_design":null,"title":"A Phase 2b randomized clinical trial of the oral p38\u03b1 inhibitor neflamapimod in dementia with Lewy bodies (DLB)","title_match":false,"year":2026},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/early-alzheimer-s-disease-blood-biomarkers-are-associated-with-a-42449187","doi":"10.1002/alz.71631","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":394,"pmid":"42449187","source_url":"https://pubmed.ncbi.nlm.nih.gov/42449187/","study_design":null,"title":"Early Alzheimer\u00b4s disease blood biomarkers are associated with a higher risk for postoperative long-term cognitive decline: Insights from the FINDERI study","title_match":false,"year":2026},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/performance-of-alzheimer-disease-plasma-biomarkers-in-patients-with-42441927","doi":"10.1212/wnl.0000000000214712","journal":"Neurology","n_participants":345,"pmid":"42441927","source_url":"https://pubmed.ncbi.nlm.nih.gov/42441927/","study_design":"cohort study","title":"Performance of Alzheimer Disease Plasma Biomarkers in Patients With Prion Diseases","title_match":true,"year":2026},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-217-in-participants-at-risk-for-chronic-42440317","doi":"10.1001/jamanetworkopen.2026.22966","journal":"JAMA network open","n_participants":231,"pmid":"42440317","source_url":"https://pubmed.ncbi.nlm.nih.gov/42440317/","study_design":"case-control study","title":"Plasma Phosphorylated Tau 217 in Participants at Risk for Chronic Traumatic Encephalopathy","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/abnormalities-in-core-ad-biomarkers-precede-inflammatory-and-glial-2a0fe361","doi":"10.64898/2026.03.31.26349851","journal":"medRxiv","n_participants":484,"pmid":null,"source_url":"https://doi.org/10.64898/2026.03.31.26349851","study_design":null,"title":"Abnormalities in core AD biomarkers precede inflammatory and glial markers in CSF in Autosomal Dominant Alzheimer\u2019s Disease","title_match":false,"year":2026},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-for-early-diagnosis-of-alzheimer-s-disease-a-42243744","doi":"10.1186/s12883-026-05046-6","journal":"BMC neurology","n_participants":null,"pmid":"42243744","source_url":"https://pubmed.ncbi.nlm.nih.gov/42243744/","study_design":"systematic review","title":"Blood-based biomarkers for early diagnosis of Alzheimer's disease: a current systematic review of diagnostic accuracy studies","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-for-alzheimer-disease-across-ethnoracial-groups-and-de7bbfdf","doi":"10.64898/2026.05.14.26353162","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.05.14.26353162","study_design":"meta-analysis","title":"Blood biomarkers for Alzheimer disease across ethnoracial groups and healthcare settings: a systematic review and meta-analysis","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/associations-of-blood-biomarkers-of-glial-cell-dysfunction-and-42092335","doi":"10.1002/alz.71422","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":3082,"pmid":"42092335","source_url":"https://pubmed.ncbi.nlm.nih.gov/42092335/","study_design":null,"title":"Associations of blood biomarkers of glial cell dysfunction and neuronal injury with future cognitive decline and incident dementia","title_match":false,"year":2026},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/impaired-lung-function-is-associated-with-elevated-blood-biomarkers-41981149","doi":"10.1038/s41598-026-48115-z","journal":"Scientific reports","n_participants":4072,"pmid":"41981149","source_url":"https://pubmed.ncbi.nlm.nih.gov/41981149/","study_design":null,"title":"Impaired lung function is associated with elevated blood biomarkers of AD/ADRD: unraveling the interplay with risk of dementia","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/grip-strength-modifies-the-association-between-blood-based-alzheimer-41964835","doi":"10.1007/s11357-026-02246-3","journal":"GeroScience","n_participants":348,"pmid":"41964835","source_url":"https://pubmed.ncbi.nlm.nih.gov/41964835/","study_design":"cross-sectional","title":"Grip strength modifies the association between blood-based alzheimer's biomarkers and cognitive function","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/diagnostic-performance-of-plasma-gfap-in-preclinical-stages-of-41845424","doi":"10.1186/s13195-026-02012-9","journal":"Alzheimer's research & therapy","n_participants":143,"pmid":"41845424","source_url":"https://pubmed.ncbi.nlm.nih.gov/41845424/","study_design":null,"title":"Diagnostic performance of plasma GFAP in preclinical stages of Alzheimer's disease using the Lumipulse platform","title_match":true,"year":2026},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-as-a-potential-biomarker-of-30055655","doi":"10.1186/s13195-018-0404-9","journal":"Alzheimer's research & therapy","n_participants":25,"pmid":"30055655","source_url":"https://pubmed.ncbi.nlm.nih.gov/30055655/","study_design":null,"title":"Plasma neurofilament light as a potential biomarker of neurodegeneration in Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/plasma-glial-fibrillary-acidic-protein-is-raised-in-progranulin-31937580","doi":"10.1136/jnnp-2019-321954","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":469,"pmid":"31937580","source_url":"https://pubmed.ncbi.nlm.nih.gov/31937580/","study_design":null,"title":"Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia","title_match":false,"year":2020},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/mood-changes-in-cognitively-normal-older-adults-are-linked-to-27426238","doi":"10.1016/j.jagp.2016.04.004","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":118,"pmid":"27426238","source_url":"https://pubmed.ncbi.nlm.nih.gov/27426238/","study_design":"longitudinal study","title":"Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels","title_match":false,"year":2016},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/individualized-prognosis-of-cognitive-decline-and-dementia-in-mild-37117993","doi":"10.1038/s43587-020-00003-5","journal":"Nature aging","n_participants":573,"pmid":"37117993","source_url":"https://pubmed.ncbi.nlm.nih.gov/37117993/","study_design":"longitudinal study","title":"Individualized prognosis of cognitive decline and dementia in mild cognitive impairment based on plasma biomarker combinations","title_match":true,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/longitudinal-change-in-csf-tau-and-a-biomarkers-for-up-to-48-months-23812320","doi":"10.1007/s00401-013-1151-4","journal":"Acta neuropathologica","n_participants":null,"pmid":"23812320","source_url":"https://pubmed.ncbi.nlm.nih.gov/23812320/","study_design":"cross-sectional","title":"Longitudinal change in CSF Tau and A\u03b2 biomarkers for up to 48 months in ADNI","title_match":false,"year":2013},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-and-risk-of-alzheimer-s-disease-in-the-framingham-25217292","doi":"10.1016/j.jalz.2014.07.001","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":2189,"pmid":"25217292","source_url":"https://pubmed.ncbi.nlm.nih.gov/25217292/","study_design":null,"title":"Plasma amyloid-\u03b2 and risk of Alzheimer's disease in the Framingham Heart Study","title_match":true,"year":2015},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/stage-specific-links-between-plasma-neurofilament-light-and-imaging-33210117","doi":"10.1093/brain/awaa342","journal":"Brain : a journal of neurology","n_participants":1149,"pmid":"33210117","source_url":"https://pubmed.ncbi.nlm.nih.gov/33210117/","study_design":"cross-sectional","title":"Stage-specific links between plasma neurofilament light and imaging biomarkers of Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-for-prediction-of-disease-progression-in-33827960","doi":"10.1212/wnl.0000000000011848","journal":"Neurology","n_participants":277,"pmid":"33827960","source_url":"https://pubmed.ncbi.nlm.nih.gov/33827960/","study_design":"longitudinal study","title":"Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration","title_match":false,"year":2021},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/sex-differences-in-plasma-p-tau181-associations-with-alzheimer-s-35768637","doi":"10.1038/s41380-022-01675-8","journal":"Molecular psychiatry","n_participants":null,"pmid":"35768637","source_url":"https://pubmed.ncbi.nlm.nih.gov/35768637/","study_design":null,"title":"Sex differences in plasma p-tau181 associations with Alzheimer's disease biomarkers, cognitive decline, and clinical progression","title_match":true,"year":2022},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-levels-in-alzheimer-s-disease-28428015","doi":"10.1016/j.neulet.2017.04.027","journal":"Neuroscience letters","n_participants":193,"pmid":"28428015","source_url":"https://pubmed.ncbi.nlm.nih.gov/28428015/","study_design":null,"title":"Plasma neurofilament light chain levels in Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/csf-synuclein-improves-diagnostic-and-prognostic-performance-of-csf-23812319","doi":"10.1007/s00401-013-1148-z","journal":"Acta neuropathologica","n_participants":389,"pmid":"23812319","source_url":"https://pubmed.ncbi.nlm.nih.gov/23812319/","study_design":"longitudinal study","title":"CSF \u03b1-synuclein improves diagnostic and prognostic performance of CSF tau and A\u03b2 in Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/comparison-of-plasma-neurofilament-light-and-total-tau-as-34906229","doi":"10.1186/s13195-021-00944-y","journal":"Alzheimer's research & therapy","n_participants":995,"pmid":"34906229","source_url":"https://pubmed.ncbi.nlm.nih.gov/34906229/","study_design":"cross-sectional","title":"Comparison of plasma neurofilament light and total tau as neurodegeneration markers: associations with cognitive and neuroimaging outcomes","title_match":false,"year":2021},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/longitudinal-plasma-phosphorylated-tau-181-tracks-disease-progression-34120152","doi":"10.1038/s41398-021-01476-7","journal":"Translational psychiatry","n_participants":1184,"pmid":"34120152","source_url":"https://pubmed.ncbi.nlm.nih.gov/34120152/","study_design":"longitudinal study","title":"Longitudinal plasma phosphorylated tau 181 tracks disease progression in Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/c-reactive-protein-plasma-amyloid-levels-and-their-interaction-with-30355213","doi":"10.1161/strokeaha.118.022317","journal":"Stroke","n_participants":736,"pmid":"30355213","source_url":"https://pubmed.ncbi.nlm.nih.gov/30355213/","study_design":"longitudinal study","title":"C-Reactive Protein, Plasma Amyloid-\u03b2 Levels, and Their Interaction With Magnetic Resonance Imaging Markers","title_match":true,"year":2018},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/plasma-p-tau181-level-predicts-neurodegeneration-and-progression-to-34557143","doi":"10.3389/fneur.2021.695696","journal":"Frontiers in neurology","n_participants":185,"pmid":"34557143","source_url":"https://pubmed.ncbi.nlm.nih.gov/34557143/","study_design":"cross-sectional","title":"Plasma p-tau181 Level Predicts Neurodegeneration and Progression to Alzheimer's Dementia: A Longitudinal Study","title_match":true,"year":2021},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-tau-and-neurodegeneration-biomarker-profiles-predict-33005724","doi":"10.1002/dad2.12104","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":183,"pmid":"33005724","source_url":"https://pubmed.ncbi.nlm.nih.gov/33005724/","study_design":"cross-sectional","title":"Plasma amyloid, tau, and neurodegeneration biomarker profiles predict Alzheimer's disease pathology and clinical progression in older adults without dementia","title_match":true,"year":2020},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-levels-cerebral-small-vessel-disease-and-cognition-the-28984600","doi":"10.3233/jad-170458","journal":"Journal of Alzheimer's disease : JAD","n_participants":1201,"pmid":"28984600","source_url":"https://pubmed.ncbi.nlm.nih.gov/28984600/","study_design":"meta-analysis","title":"Plasma Amyloid-\u03b2 Levels, Cerebral Small Vessel Disease, and Cognition: The Rotterdam Study","title_match":true,"year":2017},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/association-between-polygenic-risk-score-of-alzheimer-s-disease-and-33419453","doi":"10.1186/s13195-020-00754-8","journal":"Alzheimer's research & therapy","n_participants":818,"pmid":"33419453","source_url":"https://pubmed.ncbi.nlm.nih.gov/33419453/","study_design":null,"title":"Association between polygenic risk score of Alzheimer's disease and plasma phosphorylated tau in individuals from the Alzheimer's Disease Neuroimaging Initiative","title_match":false,"year":2021},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-levels-cerebral-atrophy-and-risk-of-dementia-a-29960604","doi":"10.1186/s13195-018-0395-6","journal":"Alzheimer's research & therapy","n_participants":458,"pmid":"29960604","source_url":"https://pubmed.ncbi.nlm.nih.gov/29960604/","study_design":null,"title":"Plasma amyloid-\u03b2 levels, cerebral atrophy and risk of dementia: a population-based study","title_match":true,"year":2018},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/association-of-choroid-plexus-volume-with-serum-biomarkers-clinical-37500561","doi":"10.1212/wnl.0000000000207600","journal":"Neurology","n_participants":135,"pmid":"37500561","source_url":"https://pubmed.ncbi.nlm.nih.gov/37500561/","study_design":"longitudinal study","title":"Association of Choroid Plexus Volume With Serum Biomarkers, Clinical Features, and Disease Severity in Patients With Frontotemporal Lobar Degeneration Spectrum","title_match":true,"year":2023},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/soluble-p-tau217-reflects-amyloid-and-tau-pathology-and-mediates-the-33949133","doi":"10.15252/emmm.202114022","journal":"EMBO molecular medicine","n_participants":88,"pmid":"33949133","source_url":"https://pubmed.ncbi.nlm.nih.gov/33949133/","study_design":null,"title":"Soluble P-tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau","title_match":true,"year":2021},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/recurrent-seizures-progressive-cognitive-decline-parkinsonism-and-a-23667227","doi":"10.1136/bcr-2013-009853","journal":"BMJ Case Reports","n_participants":null,"pmid":"23667227","source_url":"https://pubmed.ncbi.nlm.nih.gov/23667227/","study_design":null,"title":"Recurrent seizures, progressive cognitive decline, Parkinsonism and a calcified brain: is it Fahr's disease?","title_match":false,"year":2013},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/biomarker-guided-clustering-of-alzheimer-s-disease-clinical-syndromes-31585366","doi":"10.1016/j.neurobiolaging.2019.08.032","journal":"Neurobiology of Aging","n_participants":20,"pmid":"31585366","source_url":"https://pubmed.ncbi.nlm.nih.gov/31585366/","study_design":null,"title":"Biomarker-guided clustering of Alzheimer's disease clinical syndromes","title_match":false,"year":2019},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/can-integration-of-alzheimers-plasma-biomarkers-with-mri-39291164","doi":"10.1093/braincomms/fcae300","journal":"Brain Communications","n_participants":1185,"pmid":"39291164","source_url":"https://pubmed.ncbi.nlm.nih.gov/39291164/","study_design":"cross-sectional","title":"Can integration of Alzheimer\u2019s plasma biomarkers with MRI, cardiovascular, genetics, and lifestyle measures improve cognition prediction?","title_match":true,"year":2024},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/neighborhood-disadvantage-and-the-association-of-plasma-biomarkers-0f42f421","doi":"10.1093/geroni/igae098.1504","journal":"Innovation in Aging","n_participants":136,"pmid":null,"source_url":"https://doi.org/10.1093/geroni/igae098.1504","study_design":null,"title":"NEIGHBORHOOD DISADVANTAGE AND THE ASSOCIATION OF PLASMA BIOMARKERS WITH COGNITION IN A COHORT OF DIVERSE ADULTS","title_match":true,"year":2024},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/association-of-neighborhood-disadvantage-with-alzheimer-s-disease-41285652","doi":"10.1016/j.tjpad.2025.100445","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":755,"pmid":"41285652","source_url":"https://pubmed.ncbi.nlm.nih.gov/41285652/","study_design":"cohort study","title":"Association of neighborhood disadvantage with Alzheimer's disease pathology and the stability of blood-based biomarker performance","title_match":true,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/associations-among-cognitive-performance-vcam-1-and-gfap-in-black-42431159","doi":"10.1016/j.neurobiolaging.2026.07.003","journal":"Neurobiology of Aging","n_participants":313,"pmid":"42431159","source_url":"https://pubmed.ncbi.nlm.nih.gov/42431159/","study_design":"cross-sectional","title":"Associations among cognitive performance, VCAM-1, and GFAP in black adults: The ARCHES study","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/effects-of-structural-and-social-determinants-of-health-and-b608ec21","doi":"10.1002/alz.078605","journal":"Alzheimer s & Dementia","n_participants":931,"pmid":null,"source_url":"https://doi.org/10.1002/alz.078605","study_design":null,"title":"Effects of structural and social determinants of health and comorbidities on ethno\u2010racial differences in ATN plasma biomarkers of Alzheimer\u2019s disease: A HABS\u2010HD study","title_match":true,"year":2023},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/older-adults-in-more-disadvantaged-neighborhoods-exhibit-brain-75b8b974","doi":"10.1016/j.cccb.2026.100562","journal":"Cerebral Circulation - Cognition and Behavior","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1016/j.cccb.2026.100562","study_design":null,"title":"Older adults in more disadvantaged neighborhoods exhibit brain vascular dysfunction","title_match":false,"year":2026},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/the-association-between-major-depressive-disorder-plasma-biomarkers-42079383","doi":"10.1002/dad2.70337","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","n_participants":null,"pmid":"42079383","source_url":"https://pubmed.ncbi.nlm.nih.gov/42079383/","study_design":null,"title":"The association between major depressive disorder, plasma biomarkers of Alzheimer's disease, and mild behavioral impairment among older adults","title_match":true,"year":2026},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/selected-articles-from-this-issue-e9489aa9","doi":"10.1158/1055-9965.1841.29.10","journal":"Cancer Epidemiology Biomarkers & Prevention","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1158/1055-9965.1841.29.10","study_design":null,"title":"Selected Articles from This Issue","title_match":false,"year":2020},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/clusterderived-psychosocial-phenotypes-cognitive-outcomes-and-ad-27d4bca8","doi":"10.1002/alz.083049","journal":"Alzheimer s & Dementia","n_participants":215,"pmid":null,"source_url":"https://doi.org/10.1002/alz.083049","study_design":"longitudinal study","title":"Cluster\u2010Derived Psychosocial Phenotypes, Cognitive Outcomes, and AD Plasma Biomarkers of Black and Hispanic/Latino Older Adults Enrolled in HABS\u2010HD","title_match":true,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/neighborhood-disadvantage-systemic-inflammation-and-tau-pathology-a-41520181","doi":"10.1002/alz70856_105926","journal":"Alzheimer s & Dementia","n_participants":40,"pmid":"41520181","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12790584/","study_design":"cross-sectional","title":"Neighborhood disadvantage, systemic inflammation, and tau pathology: a link between social determinants of health and Alzheimer's disease risk","title_match":false,"year":2025},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/evaluating-plasma-p-tau217-as-an-endpoint-for-alzheimer-disease-41364889","doi":"10.1212/wnl.0000000000214441","journal":"Neurology","n_participants":716,"pmid":"41364889","source_url":"https://pubmed.ncbi.nlm.nih.gov/41364889/","study_design":"longitudinal study","title":"Evaluating Plasma p-tau217 as an Endpoint for Alzheimer Disease Clinical Trials","title_match":true,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/diagnostic-value-of-serum-p-tau217-in-alzheimer-disease-equal-to-41231544","doi":"10.1093/clinchem/hvaf162","journal":"Clinical Chemistry","n_participants":100,"pmid":"41231544","source_url":"https://pubmed.ncbi.nlm.nih.gov/41231544/","study_design":null,"title":"Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility?","title_match":true,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/association-of-18-f-flortaucipirpet-and-plasma-p-tau217-with-tau-41628396","doi":"10.1212/wnl.0000000000214576","journal":"Neurology","n_participants":56,"pmid":"41628396","source_url":"https://pubmed.ncbi.nlm.nih.gov/41628396/","study_design":null,"title":"Association of [ 18 F]Flortaucipir\u2013PET and Plasma p-Tau217 With Tau Neuropathology in Alzheimer Disease and Other Neurodegenerative Disorders","title_match":true,"year":2026},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/association-of-plasma-biomarkers-of-alzheimer-disease-and-39889254","doi":"10.1212/wnl.0000000000210271","journal":"Neurology","n_participants":421,"pmid":"39889254","source_url":"https://pubmed.ncbi.nlm.nih.gov/39889254/","study_design":"longitudinal study","title":"Association of Plasma Biomarkers of Alzheimer Disease and Neurodegeneration With Longitudinal Intra-Network Functional Brain Connectivity","title_match":true,"year":2025},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/anemia-and-blood-biomarkers-of-alzheimer-disease-in-dementia-41996117","doi":"10.1001/jamanetworkopen.2026.4029","journal":"JAMA Network Open","n_participants":3363,"pmid":"41996117","source_url":"https://pubmed.ncbi.nlm.nih.gov/41996117/","study_design":"cohort study","title":"Anemia and Blood Biomarkers of Alzheimer Disease in Dementia Development","title_match":false,"year":2026},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/integrating-mri-volume-and-plasma-p-tau217-for-amyloid-risk-40829110","doi":"10.1212/wnl.0000000000213954","journal":"Neurology","n_participants":807,"pmid":"40829110","source_url":"https://pubmed.ncbi.nlm.nih.gov/40829110/","study_design":"cohort study","title":"Integrating MRI Volume and Plasma p-Tau217 for Amyloid Risk Stratification in Early-Stage Alzheimer Disease","title_match":true,"year":2025},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-blood-biomarker-concentrations-across-race-and-41269690","doi":"10.1001/jamanetworkopen.2025.45046","journal":"JAMA Network Open","n_participants":4340,"pmid":"41269690","source_url":"https://pubmed.ncbi.nlm.nih.gov/41269690/","study_design":"cohort study","title":"Alzheimer Disease Blood Biomarker Concentrations Across Race and Ethnicity Groups in Middle-Aged Adults","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/impact-of-preanalytical-delay-on-the-performance-of-plasma-a42-a42-40-41166452","doi":"10.1002/alz.70867","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41166452","source_url":"https://pubmed.ncbi.nlm.nih.gov/41166452/","study_design":"prospective cohort","title":"Impact of preanalytical delay on the performance of plasma A\u03b242, A\u03b242/40, p\u2010tau217, and p\u2010tau217/A\u03b242 in detecting brain amyloidosis in the ALZAN cohort","title_match":true,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/can-longitudinal-measures-of-plasma-biomarkers-track-disease-5bc7b467","doi":"10.1002/alz70856_105473","journal":"Alzheimer s & Dementia","n_participants":718,"pmid":null,"source_url":"https://doi.org/10.1002/alz70856_105473","study_design":"longitudinal study","title":"Can longitudinal measures of plasma biomarkers track disease progression in early Alzheimer\u00b4s Disease?","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/plasma-ptau217-predicts-petbased-pathological-staging-for-precision-41700119","doi":"10.1002/alz.71199","journal":"Alzheimer s & Dementia","n_participants":237,"pmid":"41700119","source_url":"https://pubmed.ncbi.nlm.nih.gov/41700119/","study_design":null,"title":"Plasma p\u2010tau217 predicts PET\u2010based pathological staging for precision Alzheimer disease assessment","title_match":false,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/development-of-language-composites-for-enhanced-sensitivity-to-41366787","doi":"10.1002/alz.70975","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41366787","source_url":"https://pubmed.ncbi.nlm.nih.gov/41366787/","study_design":"longitudinal study","title":"Development of language composites for enhanced sensitivity to multiple plasma biomarkers","title_match":true,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/postmortem-associations-between-alzheimer-disease-pathology-and-41610380","doi":"10.1212/wnl.0000000000214351","journal":"Neurology","n_participants":85,"pmid":"41610380","source_url":"https://pubmed.ncbi.nlm.nih.gov/41610380/","study_design":"cohort study","title":"Postmortem Associations Between Alzheimer Disease Pathology and Plasma pTau217, GFAP, and NfL in AD and AD-Related Dementias","title_match":true,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/validation-of-blood-biomarkers-for-alzheimer-disease-in-thai-cohort-41452241","doi":"10.1002/alz70856_102473","journal":"Alzheimer s & Dementia","n_participants":51,"pmid":"41452241","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12742333/","study_design":null,"title":"Validation of blood biomarkers for Alzheimer Disease in Thai Cohort","title_match":false,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/prior-traumatic-brain-injury-and-alzheimer-disease-blood-biomarkers-42371653","doi":"10.1001/jamaneurol.2026.2042","journal":"JAMA Neurology","n_participants":272,"pmid":"42371653","source_url":"https://pubmed.ncbi.nlm.nih.gov/42371653/","study_design":"cohort study","title":"Prior Traumatic Brain Injury and Alzheimer Disease Blood Biomarkers","title_match":false,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/the-relationship-between-neurofilament-light-chain-and-depressive-40352263","doi":"10.1002/trc2.70048","journal":"Alzheimer s & Dementia Translational Research & Clinical Interventions","n_participants":512,"pmid":"40352263","source_url":"https://pubmed.ncbi.nlm.nih.gov/40352263/","study_design":"cross-sectional","title":"The relationship between neurofilament light chain and depressive symptoms according to cognitive status","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/glial-fibrillary-acidic-protein-and-neurofilament-light-reference-42133312","doi":"10.1001/jamanetworkopen.2026.12793","journal":"JAMA Network Open","n_participants":179,"pmid":"42133312","source_url":"https://pubmed.ncbi.nlm.nih.gov/42133312/","study_design":"cross-sectional","title":"Glial Fibrillary Acidic Protein and Neurofilament Light Reference Intervals in Healthy Individuals","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/clinical-validation-of-new-alzheimer-disease-diagnosis-tools-based-on-41354755","doi":"10.1038/s41598-025-31613-x","journal":"Scientific Reports","n_participants":113,"pmid":"41354755","source_url":"https://pubmed.ncbi.nlm.nih.gov/41354755/","study_design":null,"title":"Clinical validation of new alzheimer disease diagnosis tools based on plasma p-Tau217","title_match":true,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/variability-in-clinical-performance-of-the-fda-cleared-lumipulse-p-42223932","doi":"10.1001/jamaneurol.2026.1565","journal":"JAMA Neurology","n_participants":null,"pmid":"42223932","source_url":"https://pubmed.ncbi.nlm.nih.gov/42223932/","study_design":"cross-sectional","title":"Variability in Clinical Performance of the FDA-Cleared Lumipulse P-Tau217/\u03b2-Amyloid 1-42 Plasma Ratio","title_match":true,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/combination-of-a40-a42-and-tau-plasma-levels-to-distinguish-amyloid-40091634","doi":"10.5607/en25008","journal":"Experimental Neurobiology","n_participants":53,"pmid":"40091634","source_url":"https://pubmed.ncbi.nlm.nih.gov/40091634/","study_design":null,"title":"Combination of A\u03b240, A\u03b242, and Tau Plasma Levels to Distinguish Amyloid-PET Positive Alzheimer Patients from Normal Controls","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/promising-clinical-tools-for-specific-alzheimer-disease-diagnosis-40348819","doi":"10.1038/s41598-025-01511-3","journal":"Scientific Reports","n_participants":134,"pmid":"40348819","source_url":"https://pubmed.ncbi.nlm.nih.gov/40348819/","study_design":null,"title":"Promising clinical tools for specific Alzheimer disease diagnosis from plasma pTau217 and ApoE genotype in a cognitive disorder unit","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/sex-differences-in-alzheimer-s-disease-plasma-biomarker-levels-and-41755682","doi":"10.1002/alz.71244","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41755682","source_url":"https://pubmed.ncbi.nlm.nih.gov/41755682/","study_design":null,"title":"Sex differences in Alzheimer's disease plasma biomarker levels and clinical utility","title_match":true,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/storage-dependent-variability-in-alzheimer-disease-related-plasma-41069044","doi":"10.1093/jnen/nlaf115","journal":"Journal of Neuropathology & Experimental Neurology","n_participants":12,"pmid":"41069044","source_url":"https://pubmed.ncbi.nlm.nih.gov/41069044/","study_design":null,"title":"Storage-dependent variability in Alzheimer disease-related plasma biomarker results using the Fujirebio Lumipulse G1200 platform","title_match":true,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/age-specific-control-and-alzheimer-disease-reference-curves-and-z-41081630","doi":"10.1093/clinchem/hvaf120","journal":"Clinical Chemistry","n_participants":1273,"pmid":"41081630","source_url":"https://pubmed.ncbi.nlm.nih.gov/41081630/","study_design":null,"title":"Age-Specific Control and Alzheimer Disease Reference Curves and z -Scores for Glial Fibrillary Acidic Protein in Blood","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/evaluation-of-a-panel-of-plasma-biomarkers-for-alzheimer-s-disease-in-41212652","doi":"10.1177/13872877251393405","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"41212652","source_url":"https://pubmed.ncbi.nlm.nih.gov/41212652/","study_design":null,"title":"Evaluation of a panel of plasma biomarkers for Alzheimer's disease in a diverse research cohort","title_match":true,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/reference-proteins-to-improve-core-1-and-core-2-alzheimers-disease-41051312","doi":"10.1093/brain/awaf375","journal":"Brain","n_participants":1702,"pmid":"41051312","source_url":"https://pubmed.ncbi.nlm.nih.gov/41051312/","study_design":"longitudinal study","title":"Reference proteins to improve Core 1 and Core 2 Alzheimer\u2019s disease CSF and plasma biomarkers","title_match":true,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/associations-of-longitudinal-changes-in-blood-biomarkers-of-dementia-40779734","doi":"10.1212/wnl.0000000000213976","journal":"Neurology","n_participants":null,"pmid":"40779734","source_url":"https://pubmed.ncbi.nlm.nih.gov/40779734/","study_design":"cross-sectional","title":"Associations of Longitudinal Changes in Blood Biomarkers of Dementia With the Proportion of Genetically Inferred African Ancestry","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/systemic-inflammation-delirium-and-clinical-progression-in-mild-41708398","doi":"10.1016/j.ebiom.2026.106159","journal":"EBioMedicine","n_participants":333,"pmid":"41708398","source_url":"https://pubmed.ncbi.nlm.nih.gov/41708398/","study_design":null,"title":"Systemic inflammation, delirium and clinical progression in mild-moderate Alzheimer disease","title_match":false,"year":2026},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/cognitive-and-brain-reserve-as-modifiers-of-early-alzheimer-41980229","doi":"10.1212/wnl.0000000000214833","journal":"Neurology","n_participants":621,"pmid":"41980229","source_url":"https://pubmed.ncbi.nlm.nih.gov/41980229/","study_design":"cross-sectional","title":"Cognitive and Brain Reserve as Modifiers of Early Alzheimer Disease\u2013Related Cognitive Vulnerability","title_match":false,"year":2026},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/impaired-lung-function-is-associated-with-elevated-blood-biomarkers-40492085","doi":"10.1038/s41598-026-48115-z","journal":"Scientific Reports","n_participants":4072,"pmid":"40492085","source_url":"https://pubmed.ncbi.nlm.nih.gov/40492085/","study_design":null,"title":"Impaired lung function is associated with elevated blood biomarkers of AD/ADRD: unraveling the interplay with risk of dementia","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/comparative-prognostic-performance-of-hippocampal-volume-and-plasma-42683796","doi":"10.3988/jcn.2025.0659","journal":"Journal of Clinical Neurology","n_participants":null,"pmid":"42683796","source_url":"https://pubmed.ncbi.nlm.nih.gov/42683796/","study_design":null,"title":"Comparative Prognostic Performance of Hippocampal Volume and Plasma Biomarkers in Amyloid-Negative Subjective Cognitive Decline: A Four-Year Follow-up","title_match":true,"year":2026},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/clinical-evaluation-of-the-revised-biological-and-clinical-staging-42314105","doi":"10.1212/wnl.0000000000218184","journal":"Neurology","n_participants":1214,"pmid":"42314105","source_url":"https://pubmed.ncbi.nlm.nih.gov/42314105/","study_design":null,"title":"Clinical Evaluation of the Revised Biological and Clinical Staging Criteria for Alzheimer Disease in China","title_match":false,"year":2026},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/recent-breakthroughs-in-blood-based-biomarkers-of-alzheimer-disease-42476554","doi":"10.1093/ageing/afag213","journal":"Age and Ageing","n_participants":null,"pmid":"42476554","source_url":"https://pubmed.ncbi.nlm.nih.gov/42476554/","study_design":null,"title":"Recent breakthroughs in blood-based biomarkers of Alzheimer disease: opportunities and challenges in older adults","title_match":true,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/association-between-alzheimer-pathology-sleep-and-cognition-in-42673553","doi":"10.1212/wnl.0000000000218476","journal":"Neurology","n_participants":null,"pmid":"42673553","source_url":"https://pubmed.ncbi.nlm.nih.gov/42673553/","study_design":null,"title":"Association Between Alzheimer Pathology, Sleep, and Cognition in Patients With Late-Onset Unexplained Epilepsy","title_match":false,"year":2026},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/adiposity-and-the-alzheimer-diseaserelated-blood-biomarker-p-tau217-0432a700","doi":"10.1212/wn9.0000000000000150","journal":"Neurology Open Access","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1212/wn9.0000000000000150","study_design":null,"title":"Adiposity and the Alzheimer Disease\u2013Related Blood Biomarker, p-Tau217, in Community-Dwelling Midlife Women","title_match":true,"year":2026},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/neurofilament-but-not-alzheimer-disease-biomarkers-in-the-acute-phase-40703816","doi":"10.1016/j.resplu.2025.101025","journal":"Resuscitation Plus","n_participants":null,"pmid":"40703816","source_url":"https://pubmed.ncbi.nlm.nih.gov/40703816/","study_design":null,"title":"Neurofilament, but not Alzheimer disease biomarkers in the acute phase correlate with cognitive performance after cardiac arrest","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-blood-biomarkers-and-cognition-in-midlife-41447483","doi":"10.1002/alz70856_101201","journal":"Alzheimer s & Dementia","n_participants":1356,"pmid":"41447483","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12740106/","study_design":null,"title":"Alzheimer disease blood biomarkers and cognition in midlife","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/interplay-between-alzheimer-and-vascular-pathology-as-determinants-of-a8b97e3a","doi":"10.1016/j.cccb.2025.100471","journal":"Cerebral Circulation - Cognition and Behavior","n_participants":421,"pmid":null,"source_url":"https://doi.org/10.1016/j.cccb.2025.100471","study_design":"cross-sectional","title":"Interplay between Alzheimer and vascular pathology as determinants of plasma neurofilament light in a memory clinic population","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/interplay-between-alzheimer-and-vascular-pathology-as-determinants-of-b9e7be23","doi":"10.1002/alz70856_104832","journal":"Alzheimer s & Dementia","n_participants":371,"pmid":null,"source_url":"https://doi.org/10.1002/alz70856_104832","study_design":null,"title":"Interplay between Alzheimer and vascular pathology as determinants of plasma neurofilament light in a memory clinic population","title_match":false,"year":2025},{"alzhub_score":30,"alzhub_url":"https://alzhub.org/study/anemia-iron-deficiency-and-blood-biomarkers-for-alzheimer-disease-42534839","doi":"10.3389/fnut.2026.1897378","journal":"Frontiers in Nutrition","n_participants":null,"pmid":"42534839","source_url":"https://pubmed.ncbi.nlm.nih.gov/42534839/","study_design":null,"title":"Anemia, iron deficiency, and blood biomarkers for Alzheimer disease: clinical interpretation and dementia risk stratification","title_match":false,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/modulatory-effect-of-glial-fibrillary-acidic-protein-gfap-levels-on-ec93d4d3","doi":"10.1002/alz70856_106267","journal":"Alzheimer s & Dementia","n_participants":354,"pmid":null,"source_url":"https://doi.org/10.1002/alz70856_106267","study_design":"longitudinal study","title":"Modulatory effect of glial fibrillary acidic protein (GFAP) levels on the association between plasma p \u2010tau217 levels and cognitive decline in older adults","title_match":false,"year":2025},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/performance-of-alzheimer-disease-plasma-biomarkers-in-a-specialty-09e4dad9","doi":"10.1212/wnl.0000000000210899","journal":"Neurology","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1212/wnl.0000000000210899","study_design":null,"title":"Performance of Alzheimer Disease Plasma Biomarkers in a Specialty Memory Clinic (S15.005)","title_match":true,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/p-tau217-como-biomarcador-sanguineo-no-diagnostico-precoce-da-doenca-b67975db","doi":"10.51891/rease.v12i9.30082","journal":"Revista Ibero-Americana de Humanidades, Ci\u00eancias e Educa\u00e7\u00e3o","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.51891/rease.v12i9.30082","study_design":"longitudinal study","title":"P-TAU217 COMO BIOMARCADOR SANGU\u00cdNEO NO DIAGN\u00d3STICO PRECOCE DA DOEN\u00c7A DE ALZHEIMER: UMA REVIS\u00c3O DA LITERATURA","title_match":true,"year":2026},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/plasma-biomarker-association-with-cognition-in-uganda-2217c07a","doi":"10.1002/alz70856_106808","journal":"Alzheimer s & Dementia","n_participants":320,"pmid":null,"source_url":"https://doi.org/10.1002/alz70856_106808","study_design":"cohort study","title":"Plasma Biomarker Association with Cognition in Uganda","title_match":true,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/nonalcoholic-fatty-liver-disease-and-longitudinal-change-in-imaging-619fe9f2","doi":"10.17615/a2cm-m654","journal":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","n_participants":1706,"pmid":null,"source_url":"https://doi.org/10.17615/a2cm-m654","study_design":null,"title":"Nonalcoholic Fatty Liver Disease and Longitudinal Change in Imaging and Plasma Biomarkers of Alzheimer Disease and Vascular Pathology","title_match":true,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-and-clinical-outcomes-in-early-onset-dementia-42054026","doi":"10.1001/jamanetworkopen.2026.9687","journal":"JAMA Network Open","n_participants":245,"pmid":"42054026","source_url":"https://pubmed.ncbi.nlm.nih.gov/42054026/","study_design":"cohort study","title":"Plasma Biomarkers and Clinical Outcomes in Early-Onset Dementia","title_match":true,"year":2026},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/trajectories-of-plasma-and-csf-mtbr-tau243-and-phosphorylated-tau-41957377","doi":"10.1038/s41467-026-71732-1","journal":"Nature Communications","n_participants":null,"pmid":"41957377","source_url":"https://pubmed.ncbi.nlm.nih.gov/41957377/","study_design":null,"title":"Trajectories of plasma and CSF MTBR-tau243 and phosphorylated-tau species across the Alzheimer\u2019s disease continuum","title_match":false,"year":2026},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-for-neocortical-tau-burden-42573994","doi":"10.1001/jamaneurol.2026.2650","journal":"JAMA Neurology","n_participants":431,"pmid":"42573994","source_url":"https://pubmed.ncbi.nlm.nih.gov/42573994/","study_design":"cohort study","title":"Plasma Biomarkers for Neocortical Tau Burden","title_match":true,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/prediction-of-continuous-amyloid-positron-emission-tomography-with-41326715","doi":"10.1038/s44321-025-00348-7","journal":"EMBO Molecular Medicine","n_participants":1053,"pmid":"41326715","source_url":"https://pubmed.ncbi.nlm.nih.gov/41326715/","study_design":null,"title":"Prediction of continuous amyloid positron emission tomography with fluid measures of phosphorylated tau and \u03b2-amyloid","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/indices-of-arterial-stiffness-and-the-alzheimers-disease-biomarker-p-42325223","doi":"10.1159/000552328","journal":"Pulse","n_participants":871,"pmid":"42325223","source_url":"https://pubmed.ncbi.nlm.nih.gov/42325223/","study_design":"cross-sectional","title":"Indices of Arterial Stiffness and the Alzheimer\u2019s Disease Biomarker, p-tau217, in Non-Demented Midlife Women","title_match":true,"year":2026},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/associations-of-anthropometry-measures-across-35-years-with-late-life-42228892","doi":"10.1212/wnl.0000000000218093","journal":"Neurology","n_participants":8797,"pmid":"42228892","source_url":"https://pubmed.ncbi.nlm.nih.gov/42228892/","study_design":null,"title":"Associations of Anthropometry Measures Across 35 Years With Late-Life Plasma P-tau217 and Dementia","title_match":true,"year":2026},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/evaluation-of-copathology-and-clinical-trajectories-in-individuals-41396614","doi":"10.1001/jamaneurol.2025.4974","journal":"JAMA Neurology","n_participants":365,"pmid":"41396614","source_url":"https://pubmed.ncbi.nlm.nih.gov/41396614/","study_design":"cohort study","title":"Evaluation of Copathology and Clinical Trajectories in Individuals With Tau-Clinical Mismatch","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/head-to-head-comparison-of-plasma-biomarker-assays-across-platforms-42633973","doi":"10.1016/j.scib.2026.08.018","journal":"\u4e2d\u56fd\u79d1\u5b66\u901a\u62a5\uff1a\u82f1\u6587\u7248","n_participants":431,"pmid":"42633973","source_url":"https://pubmed.ncbi.nlm.nih.gov/42633973/","study_design":"cross-sectional","title":"Head-to-head comparison of plasma biomarker assays across platforms for amyloid pathology in a multicenter cohort","title_match":true,"year":2026},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/analytical-and-clinical-validity-of-a-high-throughput-fully-automated-42172309","doi":"10.1093/jalm/jfag052","journal":"The Journal of Applied Laboratory Medicine","n_participants":20,"pmid":"42172309","source_url":"https://pubmed.ncbi.nlm.nih.gov/42172309/","study_design":null,"title":"Analytical and Clinical Validity of a High-Throughput, Fully Automated Immunoassay for Plasma Neurofilament Light Chain","title_match":false,"year":2026},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/optimizing-plasma-p-tau217-thresholds-for-detection-of-preclinical-c5d27418","doi":"10.1212/wnl.0000000000215003","journal":"Neurology","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1212/wnl.0000000000215003","study_design":null,"title":"Optimizing Plasma p-tau217 Thresholds for Detection of Preclinical Alzheimer\u2019s Disease Across Different Racial and Ethnic Backgrounds (P10-13.011)","title_match":true,"year":2026},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/the-association-between-polygenic-risk-for-alzheimer-s-objective-4ef9e396","doi":"10.61919/wyfc0r72","journal":"Journal of Health Wellness and Community Research","n_participants":84,"pmid":null,"source_url":"https://doi.org/10.61919/wyfc0r72","study_design":"cross-sectional","title":"The Association Between Polygenic Risk for Alzheimer's, Objective Sleep Architecture, and Plasma Neurofilament Light Chain in Midlife","title_match":false,"year":2026},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/plasma-biomarker-characterization-of-alzheimers-disease-psychosis-in-41451623","doi":"10.1002/alz70859_106556","journal":"Alzheimer s & Dementia","n_participants":322,"pmid":"41451623","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12741765/","study_design":"clinical trial","title":"Plasma Biomarker Characterization of Alzheimer\u2019s Disease Psychosis in Study ACP\u2010204\u2010006","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/age-related-prevalence-of-abnormal-plasma-p-tau217-across-racial-2e7b0be9","doi":"10.1212/wn9.0000000000000145","journal":"Neurology Open Access","n_participants":2798,"pmid":null,"source_url":"https://doi.org/10.1212/wn9.0000000000000145","study_design":"cross-sectional","title":"Age-Related Prevalence of Abnormal Plasma p-Tau217 Across Racial Ethnic Groups in the Health and Aging Brain Study-Health Disparities","title_match":true,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/differential-associations-of-core-and-non-core-plasma-biomarkers-with-42199003","doi":"10.1177/13872877261450646","journal":"Journal of Alzheimer s Disease","n_participants":334,"pmid":"42199003","source_url":"https://pubmed.ncbi.nlm.nih.gov/42199003/","study_design":"cross-sectional","title":"Differential associations of core and non-core plasma biomarkers with cognitive performance in Black adults","title_match":true,"year":2026},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/sensorimotor-measures-predict-longitudinal-cognitive-decline-and-e50209fd","doi":"10.1093/geroni/igaf122.4258","journal":"Innovation in Aging","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1093/geroni/igaf122.4258","study_design":"cohort study","title":"Sensorimotor measures predict longitudinal cognitive decline and correlate with CSF and plasma biomarkers","title_match":true,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/sensorimotor-measures-predict-longitudinal-cognitive-decline-and-1cd1d1a8","doi":"10.1093/geroni/igaf122.4189","journal":"Innovation in Aging","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1093/geroni/igaf122.4189","study_design":"cohort study","title":"Sensorimotor measures predict longitudinal cognitive decline and correlate with CSF and plasma biomarkers","title_match":true,"year":2025},{"alzhub_score":26,"alzhub_url":"https://alzhub.org/study/blutbiomarker-fur-morbus-alzheimer-296a87ae","doi":"10.1055/a-2422-1921","journal":"DMW - Deutsche Medizinische Wochenschrift","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1055/a-2422-1921","study_design":null,"title":"Blutbiomarker f\u00fcr Morbus Alzheimer","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/dynamic-changes-in-plasma-biomarkers-of-alzheimer-s-disease-in-42785333","doi":"10.1016/s1474-4422(26)00284-x","journal":"The Lancet Neurology","n_participants":1312,"pmid":"42785333","source_url":"https://pubmed.ncbi.nlm.nih.gov/42785333/","study_design":"cohort study","title":"Dynamic changes in plasma biomarkers of Alzheimer's disease in patients treated with lecanemab: a longitudinal cohort study","title_match":true,"year":2026},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/cross-sectional-associations-of-plasma-vitamin-d-with-plasma-40706903","doi":"10.1016/j.nbd.2025.107041","journal":"Neurobiology of Disease","n_participants":311,"pmid":"40706903","source_url":"https://pubmed.ncbi.nlm.nih.gov/40706903/","study_design":"cross-sectional","title":"Cross-sectional associations of plasma vitamin D with plasma phosphorylated tau-181 and plasma neurofilament light chain in older adults with memory complaints","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/associations-of-18-f-pi-2620-binding-with-memory-and-phosphorylated-42463287","doi":"10.2967/jnumed.125.271927","journal":"Journal of Nuclear Medicine","n_participants":null,"pmid":"42463287","source_url":"https://pubmed.ncbi.nlm.nih.gov/42463287/","study_design":null,"title":"Associations of [ 18 F]PI-2620 Binding with Memory and Phosphorylated Tau 217 in Cognitively Unimpaired Older Adults","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/research-proposal-consciousness-mode-alzheimers-69ec05da","doi":"10.5281/zenodo.19692806","journal":"Zenodo (CERN European Organization for Nuclear Research)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.5281/zenodo.19692806","study_design":null,"title":"Research Proposal Consciousness Mode Alzheimers","title_match":false,"year":2026},{"alzhub_score":28,"alzhub_url":"https://alzhub.org/study/research-proposal-consciousness-mode-alzheimers-63327f9e","doi":"10.5281/zenodo.19660691","journal":"Zenodo (CERN European Organization for Nuclear Research)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.5281/zenodo.19660691","study_design":null,"title":"Research Proposal Consciousness Mode Alzheimers","title_match":false,"year":2026},{"alzhub_score":30,"alzhub_url":"https://alzhub.org/study/biomarkrer-for-alzheimers-sykdom-et-fremskritt-for-hvem-42237823","doi":"10.4045/tidsskr.26.0240","journal":"Tidsskrift for Den norske legeforening","n_participants":null,"pmid":"42237823","source_url":"https://pubmed.ncbi.nlm.nih.gov/42237823/","study_design":null,"title":"Biomark\u00f8rer for Alzheimers sykdom \u2013 et fremskritt for hvem?","title_match":false,"year":2026},{"alzhub_score":25,"alzhub_url":"https://alzhub.org/study/alzheimer-krankheit-wert-pradiktiver-blut-biomarker-untersucht-f4256268","doi":"10.1055/a-2700-8954","journal":"Fortschritte der Neurologie \u00b7 Psychiatrie","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1055/a-2700-8954","study_design":null,"title":"Alzheimer-Krankheit: Wert pr\u00e4diktiver Blut-Biomarker untersucht","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/exploratory-factor-and-network-analysis-of-43-inflammatory-plasma-42684984","doi":"10.1177/13872877261481701","journal":"Journal of Alzheimer s Disease","n_participants":334,"pmid":"42684984","source_url":"https://pubmed.ncbi.nlm.nih.gov/42684984/","study_design":"cross-sectional","title":"Exploratory factor and network analysis of 43 inflammatory plasma biomarkers and cognitive performance in Black adults","title_match":true,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/cell-weighted-polygenic-risk-scores-are-associated-with-amyloid-and-41040848","doi":"10.1093/braincomms/fcaf353","journal":"Brain Communications","n_participants":734,"pmid":"41040848","source_url":"https://pubmed.ncbi.nlm.nih.gov/41040848/","study_design":null,"title":"Cell-weighted polygenic risk scores are associated with \u03b2-amyloid and tau biomarkers in Alzheimer\u2019s disease","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/microgliaspecific-alzheimer-s-disease-polygenic-risk-score-predicts-41518606","doi":"10.1002/alz70856_106441","journal":"Alzheimer s & Dementia","n_participants":474,"pmid":"41518606","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12790387/","study_design":"longitudinal study","title":"Microglia\u2010specific Alzheimer's disease polygenic risk score predicts longitudinal increase in plasma tau and faster cognitive decline in cognitively unimpaired older adults","title_match":false,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/lecanemab-use-for-early-alzheimer-disease-in-canada-42373113","doi":"10.1503/cmaj.260193","journal":"Canadian Medical Association Journal","n_participants":null,"pmid":"42373113","source_url":"https://pubmed.ncbi.nlm.nih.gov/42373113/","study_design":null,"title":"Lecanemab use for early Alzheimer disease in Canada","title_match":false,"year":2026},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-biomarkers-and-subjective-cognitive-decline-among-034324bf","doi":"10.17615/x9sz-g140","journal":"UNC Libraries","n_participants":5712,"pmid":null,"source_url":"https://doi.org/10.17615/x9sz-g140","study_design":"cross-sectional","title":"Alzheimer Disease Biomarkers and Subjective Cognitive Decline Among Hispanic and/or Latino Adults","title_match":false,"year":2026},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/identification-of-genetic-modifiers-influencing-disease-risk-in-41442552","doi":"10.1002/alz70855_105550","journal":"Alzheimer s & Dementia","n_participants":91,"pmid":"41442552","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12735601/","study_design":null,"title":"Identification of genetic modifiers influencing disease risk in autosomal dominant Alzheimer disease mutation carriers","title_match":false,"year":2025},{"alzhub_score":26,"alzhub_url":"https://alzhub.org/study/exploring-the-pathogenesis-of-alzheimer-disease-in-basal-forebrain-521df110","doi":"10.25258/ijddt.16.32s.128","journal":"International Journal of Drug Delivery Technology","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.25258/ijddt.16.32s.128","study_design":null,"title":"Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons and Converging Insights from Alternative Hypothesis","title_match":false,"year":2026},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/biologia-en-la-sangre-avances-en-biomarcadores-plasmaticos-para-el-5f0eecf0","doi":"10.63969/141q5f06","journal":"Star of Sciences Multidisciplinary Journal","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.63969/141q5f06","study_design":null,"title":"Biolog\u00eda en la sangre: avances en biomarcadores plasm\u00e1ticos para el diagn\u00f3stico de la enfermedad de Alzheimer","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/how-to-efficiently-move-towards-primary-prevention-in-sporadic-ad-41450236","doi":"10.1002/alz70859_105951","journal":"Alzheimer s & Dementia","n_participants":1000,"pmid":"41450236","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12741627/","study_design":"longitudinal study","title":"How to efficiently move towards primary prevention in sporadic AD","title_match":false,"year":2025},{"alzhub_score":29,"alzhub_url":"https://alzhub.org/study/parallel-paths-uneven-progress-health-care-provider-and-patient-41434512","doi":"10.1002/alz70861_108349","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41434512","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12726436/","study_design":null,"title":"Parallel Paths, Uneven Progress: Health Care Provider and Patient Perspectives on Anti\u2010Amyloid Therapies for Early AD","title_match":false,"year":2025},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/endogenous-lithium-levels-and-alzheimer-disease-41784383","doi":"10.1093/clinchem/hvaf174","journal":"Clinical Chemistry","n_participants":null,"pmid":"41784383","source_url":"https://pubmed.ncbi.nlm.nih.gov/41784383/","study_design":null,"title":"Endogenous Lithium Levels and Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/clinical-features-of-older-ms-patients-with-and-without-alzheimer-42556030","doi":"10.1016/j.msard.2026.107406","journal":"Multiple Sclerosis and Related Disorders","n_participants":null,"pmid":"42556030","source_url":"https://pubmed.ncbi.nlm.nih.gov/42556030/","study_design":null,"title":"Clinical features of older MS patients with and without Alzheimer disease biomarkers","title_match":false,"year":2026},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/rates-of-alzheimer-disease-biomarker-positivity-stratified-by-by-sex-d8ce6554","doi":"10.1002/alz70856_105627","journal":"Alzheimer s & Dementia","n_participants":4000,"pmid":null,"source_url":"https://doi.org/10.1002/alz70856_105627","study_design":null,"title":"Rates of Alzheimer disease biomarker positivity stratified by by sex and race in a specialty memory clinic","title_match":false,"year":2025},{"alzhub_score":26,"alzhub_url":"https://alzhub.org/study/biomarcadores-de-laboratorio-en-la-enfermedad-de-alzheimer-avances-520c3a35","doi":"10.24875/kranion.m25000107","journal":"Kranion","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.24875/kranion.m25000107","study_design":null,"title":"Biomarcadores de laboratorio en la enfermedad de Alzheimer: avances recientes e implantaci\u00f3n en un hospital de tercer nivel","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/divergent-patterns-of-cognitive-decline-in-preclinical-alzheimer-s-42015324","doi":"10.1002/alz.71366","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"42015324","source_url":"https://pubmed.ncbi.nlm.nih.gov/42015324/","study_design":"longitudinal study","title":"Divergent patterns of cognitive decline in preclinical Alzheimer's disease: Implications for secondary prevention trials","title_match":false,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/amyloid-spatial-extent-with-florbetapir-pet-for-early-detection-of-41830758","doi":"10.1016/j.tjpad.2026.100529","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":null,"pmid":"41830758","source_url":"https://pubmed.ncbi.nlm.nih.gov/41830758/","study_design":"cross-sectional","title":"Amyloid spatial extent with florbetapir-PET for early detection of preclinical Alzheimer\u2019s disease","title_match":false,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/digital-cognitive-phenotyping-enhances-risk-stratification-in-42741980","doi":"10.1002/alz.71834","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"42741980","source_url":"https://pubmed.ncbi.nlm.nih.gov/42741980/","study_design":"longitudinal study","title":"Digital cognitive phenotyping enhances risk stratification in preclinical Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/the-role-of-blood-based-biomarkers-in-parkinsonian-disorders-40682931","doi":"10.1016/j.jns.2025.123617","journal":"Journal of the Neurological Sciences","n_participants":279,"pmid":"40682931","source_url":"https://pubmed.ncbi.nlm.nih.gov/40682931/","study_design":null,"title":"The role of blood-based biomarkers in Parkinsonian disorders, Alzheimer's disease and frontotemporal dementia","title_match":true,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/unravelling-the-plasma-proteome-pioneering-biomarkers-for-40613333","doi":"10.1002/alz.70162","journal":"Alzheimer s & Dementia","n_participants":248,"pmid":"40613333","source_url":"https://pubmed.ncbi.nlm.nih.gov/40613333/","study_design":null,"title":"Unravelling the plasma proteome: Pioneering biomarkers for differential dementia diagnosis","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/biofluid-biomarkers-in-distinguishing-young-onset-dementia-from-39887317","doi":"10.1097/yco.0000000000000979","journal":"Current Opinion in Psychiatry","n_participants":46,"pmid":"39887317","source_url":"https://pubmed.ncbi.nlm.nih.gov/39887317/","study_design":null,"title":"Biofluid biomarkers in distinguishing young-onset dementia from primary psychiatric disorders","title_match":false,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/associations-between-sleep-quality-plasma-neurofilament-light-and-40379641","doi":"10.1038/s41398-025-03389-1","journal":"Translational Psychiatry","n_participants":640,"pmid":"40379641","source_url":"https://pubmed.ncbi.nlm.nih.gov/40379641/","study_design":"longitudinal study","title":"Associations between sleep quality, plasma neurofilament light, and cognition in older adults without dementia","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-p-tau181-amyloid-beta-42-ratio-identifies-40757274","doi":"10.1021/acsomega.5c03650","journal":"ACS Omega","n_participants":43,"pmid":"40757274","source_url":"https://pubmed.ncbi.nlm.nih.gov/40757274/","study_design":null,"title":"Cerebrospinal Fluid p-Tau181/Amyloid Beta 42 Ratio Identifies Lymphatic-Venous Anastomosis Patients Who Respond to and Benefit from the Surgery for Relief of Cognitive Impairment with a Diagnostic Accuracy of 0.744","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/assessment-of-plasma-and-cerebrospinal-fluid-biomarkers-in-patients-40362548","doi":"10.3390/ijms26094308","journal":"International Journal of Molecular Sciences","n_participants":51,"pmid":"40362548","source_url":"https://pubmed.ncbi.nlm.nih.gov/40362548/","study_design":null,"title":"Assessment of Plasma and Cerebrospinal Fluid Biomarkers in Patients with Alzheimer\u2019s Disease and Other Dementias: A Center-Based Study","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/prevalence-aetiology-and-service-mapping-of-dementia-in-rural-uganda-2759073b","doi":"10.12688/wellcomeopenres.22944.2","journal":"Wellcome Open Research","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.12688/wellcomeopenres.22944.2","study_design":null,"title":"Prevalence, aetiology, and service mapping of dementia in rural Uganda. Part of DEPEND Uganda (Dementia Epidemiology, unmet Need and co-Developing Solutions in Uganda)","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/exploring-cognitive-and-neuroimaging-profiles-of-dementia-subtypes-of-40013096","doi":"10.3389/fnagi.2025.1552348","journal":"Frontiers in Aging Neuroscience","n_participants":45,"pmid":"40013096","source_url":"https://pubmed.ncbi.nlm.nih.gov/40013096/","study_design":null,"title":"Exploring cognitive and neuroimaging profiles of dementia subtypes of individuals with dementia in the Democratic Republic of Congo","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/accuracy-of-blood-based-neurofilament-light-to-different-genetic-40605462","doi":"10.1177/13872877251352103","journal":"Journal of Alzheimer s Disease","n_participants":474,"pmid":"40605462","source_url":"https://pubmed.ncbi.nlm.nih.gov/40605462/","study_design":null,"title":"Accuracy of blood-based neurofilament light to different genetic frontotemporal dementia from primary psychiatric disorders","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/diagnostic-value-of-fluidbased-nonamyloid-biomarkers-for-alzheimer-s-40438038","doi":"10.1002/dad2.70129","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","n_participants":70,"pmid":"40438038","source_url":"https://pubmed.ncbi.nlm.nih.gov/40438038/","study_design":null,"title":"Diagnostic value of fluid\u2010based non\u2010amyloid biomarkers for Alzheimer's disease and related dementias in a clinic\u2010based cohort from South Asia","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/diadem-digital-assessment-of-auditory-perception-in-dementia-study-41441593","doi":"10.1002/alz70856_098358","journal":"Alzheimer s & Dementia","n_participants":600,"pmid":"41441593","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12730523/","study_design":"cohort study","title":"(DIADEM) Digital Assessment of Auditory Perception in Dementia : Study Protocol","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/a-harmonized-visual-reading-framework-for-tau-pet-staging-in-42766299","doi":"10.1001/jamaneurol.2026.3253","journal":"JAMA Neurology","n_participants":681,"pmid":"42766299","source_url":"https://pubmed.ncbi.nlm.nih.gov/42766299/","study_design":"cross-sectional","title":"A Harmonized Visual Reading Framework for Tau PET Staging in Alzheimer Disease","title_match":false,"year":2026},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amyloid-probability-in-alzheimer-disease-from-plasma-cerebrospinal-6f44c1d3","doi":"10.1038/s44400-026-00109-4","journal":"npj Dementia","n_participants":320,"pmid":null,"source_url":"https://doi.org/10.1038/s44400-026-00109-4","study_design":"cross-sectional","title":"Amyloid probability in Alzheimer disease from plasma, cerebrospinal fluid, and amyloid imaging","title_match":false,"year":2026},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/evaluation-of-a-sensitive-visual-read-algorithm-for-assessing-3r-4r-40908124","doi":"10.2967/jnumed.125.269685","journal":"Journal of Nuclear Medicine","n_participants":1654,"pmid":"40908124","source_url":"https://pubmed.ncbi.nlm.nih.gov/40908124/","study_design":"cohort study","title":"Evaluation of a Sensitive Visual Read Algorithm for Assessing 3R/4R Tau PET Images","title_match":false,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/18f-ro948-tau-pet-imaging-and-plasma-biomarkers-in-part-and-late-1419fb90","doi":"10.1002/alz70856_107395","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1002/alz70856_107395","study_design":null,"title":"[18F] RO948 Tau PET imaging and plasma biomarkers in PART and LATE patients compared with sporadic Alzheimer's Disease","title_match":true,"year":2025},{"alzhub_score":30,"alzhub_url":"https://alzhub.org/study/blood-phosphorylated-tau-for-the-diagnosis-of-alzheimer-disease-42201264","doi":"10.1093/clinchem/hvag048","journal":"Clinical Chemistry","n_participants":null,"pmid":"42201264","source_url":"https://pubmed.ncbi.nlm.nih.gov/42201264/","study_design":null,"title":"Blood Phosphorylated Tau for the Diagnosis of Alzheimer Disease","title_match":false,"year":2026},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/rural-health-disparities-in-alzheimers-disease-and-related-dementias-4d25e5d3","doi":"10.1093/geroni/igaf122.024","journal":"Innovation in Aging","n_participants":25,"pmid":null,"source_url":"https://doi.org/10.1093/geroni/igaf122.024","study_design":null,"title":"Rural Health Disparities in Alzheimer\u2019s Disease and Related Dementias Biomarker Testing","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/informing-etiological-heterogeneity-of-mild-cognitive-impairment-and-39800468","doi":"10.1016/j.tjpad.2024.100011","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":104,"pmid":"39800468","source_url":"https://pubmed.ncbi.nlm.nih.gov/39800468/","study_design":"cross-sectional","title":"Informing etiological heterogeneity of mild cognitive impairment and risk for progression to dementia with plasma p-tau217","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/association-of-epigenetic-aging-with-plasma-biomarkers-of-amyloid-tau-40750903","doi":"10.1186/s13148-025-01941-w","journal":"Clinical Epigenetics","n_participants":null,"pmid":"40750903","source_url":"https://pubmed.ncbi.nlm.nih.gov/40750903/","study_design":null,"title":"Association of epigenetic aging with plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in Hispanic/Latino adults","title_match":true,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/spotlight-on-alzheimer-s-disease-and-related-dementias-research-in-40641055","doi":"10.1002/alz.70479","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40641055","source_url":"https://pubmed.ncbi.nlm.nih.gov/40641055/","study_design":null,"title":"Spotlight on Alzheimer's disease and related dementias research in East Asia","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/impact-of-apoe4related-dementia-risk-in-underrepresented-groups-from-40501118","doi":"10.1002/alz.70245","journal":"Alzheimer s & Dementia","n_participants":9784,"pmid":"40501118","source_url":"https://pubmed.ncbi.nlm.nih.gov/40501118/","study_design":"longitudinal study","title":"Impact of APOE4\u2010related dementia risk in underrepresented groups from the All of Us research program","title_match":false,"year":2025},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-of-alzheimers-disease-and-incident-dementia-in-40140622","doi":"10.1038/s41591-025-03605-x","journal":"Nature Medicine","n_participants":null,"pmid":"40140622","source_url":"https://pubmed.ncbi.nlm.nih.gov/40140622/","study_design":null,"title":"Blood-based biomarkers of Alzheimer\u2019s disease and incident dementia in the community","title_match":true,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/performance-of-plasma-biomarkers-for-diagnosis-and-prediction-of-40133253","doi":"10.1038/s41467-025-56756-3","journal":"Nature Communications","n_participants":49,"pmid":"40133253","source_url":"https://pubmed.ncbi.nlm.nih.gov/40133253/","study_design":"cohort study","title":"Performance of plasma biomarkers for diagnosis and prediction of dementia in a Brazilian cohort","title_match":true,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/targeted-proteomic-biomarker-profiling-using-nulisa-in-a-cohort-40318118","doi":"10.1002/alz.70166","journal":"Alzheimer s & Dementia","n_participants":252,"pmid":"40318118","source_url":"https://pubmed.ncbi.nlm.nih.gov/40318118/","study_design":"cross-sectional","title":"Targeted proteomic biomarker profiling using NULISA in a cohort enriched with risk for Alzheimer's disease and related dementias","title_match":false,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/prevalence-of-alzheimers-disease-pathology-in-the-community-41407852","doi":"10.1038/s41586-025-09841-y","journal":"Nature","n_participants":null,"pmid":"41407852","source_url":"https://pubmed.ncbi.nlm.nih.gov/41407852/","study_design":null,"title":"Prevalence of Alzheimer\u2019s disease pathology in the community","title_match":false,"year":2025},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/evaluating-the-diagnostic-performance-of-six-plasma-biomarkers-for-40181481","doi":"10.1186/s13195-025-01712-y","journal":"Alzheimer s Research & Therapy","n_participants":668,"pmid":"40181481","source_url":"https://pubmed.ncbi.nlm.nih.gov/40181481/","study_design":"cross-sectional","title":"Evaluating the diagnostic performance of six plasma biomarkers for Alzheimer\u2019s disease and other neurodegenerative dementias in a large Chinese cohort","title_match":true,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-identify-brain-atn-abnormalities-in-a-dementia-free-40713737","doi":"10.1186/s13195-025-01803-w","journal":"Alzheimer s Research & Therapy","n_participants":113,"pmid":"40713737","source_url":"https://pubmed.ncbi.nlm.nih.gov/40713737/","study_design":null,"title":"Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort","title_match":true,"year":2025},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/plasma-ptau181-and-amyloid-markers-predict-conversion-to-dementia-in-39761530","doi":"10.1093/brain/awaf003","journal":"Brain","n_participants":158,"pmid":"39761530","source_url":"https://pubmed.ncbi.nlm.nih.gov/39761530/","study_design":"cohort study","title":"Plasma pTau181 and amyloid markers predict conversion to dementia in idiopathic REM sleep behaviour disorder","title_match":true,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/the-dementia-somasignal-test-dsst-a-plasma-proteomic-predictor-of-39936291","doi":"10.1002/alz.14549","journal":"Alzheimer s & Dementia","n_participants":11277,"pmid":"39936291","source_url":"https://pubmed.ncbi.nlm.nih.gov/39936291/","study_design":"longitudinal study","title":"The Dementia SomaSignal Test (dSST): A plasma proteomic predictor of 20\u2010year dementia risk","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/development-and-validation-of-machine-learning-models-with-blood-40115175","doi":"10.1016/j.eclinm.2025.103142","journal":"EClinicalMedicine","n_participants":1324,"pmid":"40115175","source_url":"https://pubmed.ncbi.nlm.nih.gov/40115175/","study_design":null,"title":"Development and validation of machine learning models with blood-based digital biomarkers for Alzheimer\u2019s disease diagnosis: a multicohort diagnostic study","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/machine-learning-models-for-dementia-screening-to-classify-brain-39838434","doi":"10.1186/s13195-024-01650-1","journal":"Alzheimer s Research & Therapy","n_participants":15,"pmid":"39838434","source_url":"https://pubmed.ncbi.nlm.nih.gov/39838434/","study_design":null,"title":"Machine learning models for dementia screening to classify brain amyloid positivity on positron emission tomography using blood markers and demographic characteristics: a retrospective observational study","title_match":false,"year":2025},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/dementia-etiology-classification-using-nulisa-plasma-biomarkers-and-41394895","doi":"10.1002/alz.71603","journal":"Alzheimer s & Dementia","n_participants":194,"pmid":"41394895","source_url":"https://pubmed.ncbi.nlm.nih.gov/41394895/","study_design":"systematic review","title":"Dementia etiology classification using NULISA plasma biomarkers and machine learning","title_match":true,"year":2026},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/machine-learning-and-data-driven-inverse-modeling-of-metabolomics-40993122","doi":"10.1038/s41540-025-00580-4","journal":"npj Systems Biology and Applications","n_participants":null,"pmid":"40993122","source_url":"https://pubmed.ncbi.nlm.nih.gov/40993122/","study_design":null,"title":"Machine learning and data-driven inverse modeling of metabolomics unveil key processes of active aging","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/vascular-cognitive-impairment-and-dementia-prevention-treatments-41554956","doi":"10.1038/s41386-026-02331-3","journal":"Neuropsychopharmacology","n_participants":null,"pmid":"41554956","source_url":"https://pubmed.ncbi.nlm.nih.gov/41554956/","study_design":null,"title":"Vascular cognitive impairment and dementia: Prevention, treatments, mechanisms and management options for the future","title_match":false,"year":2026},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/association-of-rapid-eye-movement-sleep-latency-with-multimodal-39868572","doi":"10.1002/alz.14495","journal":"Alzheimer s & Dementia","n_participants":128,"pmid":"39868572","source_url":"https://pubmed.ncbi.nlm.nih.gov/39868572/","study_design":null,"title":"Association of rapid eye movement sleep latency with multimodal biomarkers of Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/recent-advances-in-neuroimaging-of-alzheimer-s-disease-and-related-40922096","doi":"10.1002/alz.70648","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40922096","source_url":"https://pubmed.ncbi.nlm.nih.gov/40922096/","study_design":null,"title":"Recent advances in neuroimaging of Alzheimer's disease and related dementias","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/phosphorylated-tau-217-in-young-adults-with-down-syndrome-and-down-10090373","doi":"10.1038/s43856-026-01921-y","journal":"Communications Medicine","n_participants":132,"pmid":null,"source_url":"https://doi.org/10.1038/s43856-026-01921-y","study_design":"longitudinal study","title":"Phosphorylated tau 217 in young adults with Down syndrome and Down syndrome regression disorder","title_match":false,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/b31-13-circadian-rest-activity-rhythm-and-alzheimers-disease-02ad0ff8","doi":"10.1093/ajrccm/aamag162.6475","journal":"American Journal of Respiratory and Critical Care Medicine","n_participants":29,"pmid":null,"source_url":"https://doi.org/10.1093/ajrccm/aamag162.6475","study_design":"cross-sectional","title":"B31-13 Circadian Rest-Activity Rhythm and Alzheimer\u2019s Disease Biomarkers in Adults With Down Syndrome","title_match":false,"year":2026},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/early-detection-of-white-matter-integrity-changes-in-down-syndrome-89e62d72","doi":"10.1002/alz70856_106537","journal":"Alzheimer s & Dementia","n_participants":70,"pmid":null,"source_url":"https://doi.org/10.1002/alz70856_106537","study_design":null,"title":"Early Detection of White Matter Integrity Changes in Down Syndrome: The Promise of PSMD as a Sensitive Biomarker","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/frontotemporal-dementia-how-to-deal-with-its-diagnostic-complexity-39911129","doi":"10.1080/14737175.2025.2461758","journal":"Expert Review of Neurotherapeutics","n_participants":null,"pmid":"39911129","source_url":"https://pubmed.ncbi.nlm.nih.gov/39911129/","study_design":null,"title":"Frontotemporal dementia. How to deal with its diagnostic complexity?","title_match":false,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/sex-differences-in-the-clinical-manifestation-of-autosomal-dominant-40277077","doi":"10.1002/alz.14630","journal":"Alzheimer s & Dementia","n_participants":337,"pmid":"40277077","source_url":"https://pubmed.ncbi.nlm.nih.gov/40277077/","study_design":"longitudinal study","title":"Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/neuroimaging-and-plasma-biomarker-differences-and-commonalities-in-40403153","doi":"10.1002/alz.70274","journal":"Alzheimer s & Dementia","n_participants":47,"pmid":"40403153","source_url":"https://pubmed.ncbi.nlm.nih.gov/40403153/","study_design":null,"title":"Neuroimaging and plasma biomarker differences and commonalities in Lewy body dementia subtypes","title_match":true,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/changes-in-dti-alps-index-and-its-associations-with-neuronal-damage-40921114","doi":"10.1016/j.parkreldis.2025.108014","journal":"Parkinsonism & Related Disorders","n_participants":32,"pmid":"40921114","source_url":"https://pubmed.ncbi.nlm.nih.gov/40921114/","study_design":"longitudinal study","title":"Changes in DTI-ALPS index and its associations with neuronal damage in Lewy body disease","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-in-the-distinction-of-alzheimers-disease-and-39940998","doi":"10.3390/ijms26031231","journal":"International Journal of Molecular Sciences","n_participants":108,"pmid":"39940998","source_url":"https://pubmed.ncbi.nlm.nih.gov/39940998/","study_design":null,"title":"Plasma Biomarkers in the Distinction of Alzheimer\u2019s Disease and Frontotemporal Dementia","title_match":true,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/disease-modifying-effects-of-tmem106b-in-genetic-frontotemporal-40260680","doi":"10.1093/brain/awaf019","journal":"Brain","n_participants":518,"pmid":"40260680","source_url":"https://pubmed.ncbi.nlm.nih.gov/40260680/","study_design":"cohort study","title":"Disease-modifying effects of TMEM106B in genetic frontotemporal dementia: a longitudinal GENFI study","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/plasma-ptau217-nfl-gfap-diagnostic-performance-and-biomarker-profiles-41025379","doi":"10.1002/alz.70717","journal":"Alzheimer s & Dementia","n_participants":40,"pmid":"41025379","source_url":"https://pubmed.ncbi.nlm.nih.gov/41025379/","study_design":null,"title":"Plasma p\u2010tau217, NfL, GFAP diagnostic performance and biomarker profiles in Alzheimer's disease, frontotemporal dementia, and psychiatric disorders, in a prospective unselected neuropsychiatry memory clinic","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/safety-cognitive-and-behavioral-outcomes-in-patients-with-dementia-40565990","doi":"10.3390/jcm14124245","journal":"Journal of Clinical Medicine","n_participants":43,"pmid":"40565990","source_url":"https://pubmed.ncbi.nlm.nih.gov/40565990/","study_design":"clinical trial","title":"Safety, Cognitive, and Behavioral Outcomes in Patients with Dementia with Lewy Bodies Treated with Nilotinib","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/clinical-and-neuropathological-associations-of-plasma-a42-a40-ptau217-39886325","doi":"10.1002/dad2.70078","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","n_participants":620,"pmid":"39886325","source_url":"https://pubmed.ncbi.nlm.nih.gov/39886325/","study_design":"longitudinal study","title":"Clinical and neuropathological associations of plasma A\u03b242/A\u03b240, p\u2010tau217 and neurofilament light in sporadic frontotemporal dementia spectrum disorders","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-ptau217-and-a42-40-as-markers-of-a-pathology-in-the-lewy-body-41075284","doi":"10.1002/alz.70788","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41075284","source_url":"https://pubmed.ncbi.nlm.nih.gov/41075284/","study_design":null,"title":"Plasma p\u2010tau217 and A\u03b242/40 as markers of A\u03b2 pathology in the Lewy body continuum","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/glymphatic-activity-is-linked-to-the-synaptic-vesicle-cycle-pathway-41061808","doi":"10.1016/j.nbd.2025.107135","journal":"Neurobiology of Disease","n_participants":37,"pmid":"41061808","source_url":"https://pubmed.ncbi.nlm.nih.gov/41061808/","study_design":null,"title":"Glymphatic activity is linked to the synaptic vesicle cycle pathway in frontotemporal dementia: A metabolomics study","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/the-association-between-plasma-and-mri-biomarkers-in-dementia-with-40847319","doi":"10.1186/s13195-025-01848-x","journal":"Alzheimer s Research & Therapy","n_participants":92,"pmid":"40847319","source_url":"https://pubmed.ncbi.nlm.nih.gov/40847319/","study_design":null,"title":"The association between plasma and MRI biomarkers in dementia with lewy bodies","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/allostatic-load-dynamics-alzheimer-s-disease-biomarkers-and-40606518","doi":"10.1002/dad2.70140","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","n_participants":385,"pmid":"40606518","source_url":"https://pubmed.ncbi.nlm.nih.gov/40606518/","study_design":null,"title":"Allostatic load dynamics, Alzheimer's disease biomarkers, and progression in individuals with mild cognitive impairment: findings from the Alzheimer's Disease Neuroimaging Initiative","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/the-patient-pathway-for-mild-cognitive-impairment-due-to-alzheimers-40483260","doi":"10.1016/j.tjpad.2025.100215","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":31,"pmid":"40483260","source_url":"https://pubmed.ncbi.nlm.nih.gov/40483260/","study_design":null,"title":"The patient pathway for mild cognitive impairment due to Alzheimer\u2019s disease in Asia: Current practices, barriers, and expert recommendations for optimization","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/blood-neurofilament-light-chain-and-phospho-tau-181-in-subjects-with-39941343","doi":"10.3390/jcm14030672","journal":"Journal of Clinical Medicine","n_participants":30,"pmid":"39941343","source_url":"https://pubmed.ncbi.nlm.nih.gov/39941343/","study_design":null,"title":"Blood Neurofilament Light Chain and Phospho-Tau 181 in Subjects with Mild Cognitive Impairment Due to Age-Related Hearing Loss","title_match":false,"year":2025},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-and-disease-prognosis-in-mild-cognitive-impairment-40156325","doi":"10.1002/mds.30181","journal":"Movement Disorders","n_participants":131,"pmid":"40156325","source_url":"https://pubmed.ncbi.nlm.nih.gov/40156325/","study_design":"longitudinal study","title":"Plasma Biomarkers and Disease Prognosis in Mild Cognitive Impairment with Lewy Bodies","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/prediction-of-mild-cognitive-impairment-progression-using-time-41040687","doi":"10.1126/sciadv.aee2305","journal":"Science Advances","n_participants":102,"pmid":"41040687","source_url":"https://pubmed.ncbi.nlm.nih.gov/41040687/","study_design":null,"title":"Prediction of mild cognitive impairment progression using time-sensitive multimodal biomarkers","title_match":false,"year":2026},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau217a-pivotal-plasma-biomarker-for-predicting-42117479","doi":"10.1080/13803395.2026.2671206","journal":"Journal of Clinical and Experimental Neuropsychology","n_participants":47,"pmid":"42117479","source_url":"https://pubmed.ncbi.nlm.nih.gov/42117479/","study_design":"longitudinal study","title":"Plasma Phosphorylated Tau217\u2013A Pivotal Plasma Biomarker for Predicting the Progression of Mild Cognitive Impairment to Alzheimer\u2019s Disease: A Reanalysis of ADNI Data","title_match":true,"year":2026},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-of-alzheimers-disease-and-progression-across-41276530","doi":"10.1038/s41467-025-66728-2","journal":"Nature Communications","n_participants":null,"pmid":"41276530","source_url":"https://pubmed.ncbi.nlm.nih.gov/41276530/","study_design":null,"title":"Blood biomarkers of Alzheimer\u2019s disease and progression across different stages of cognitive decline in the community","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-a42-a40-determined-by-mass-spectrometry-is-associated-with-41513583","doi":"10.1016/j.tjpad.2025.100465","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":200,"pmid":"41513583","source_url":"https://pubmed.ncbi.nlm.nih.gov/41513583/","study_design":"longitudinal study","title":"Plasma A\u03b242/A\u03b240 determined by mass spectrometry is associated with longitudinal changes in amyloid accumulation, brain atrophy, and conversion to mild cognitive impairment due to Alzheimer\u2019s disease in individuals with subjective cognitive decline: 5-year follow-up of the FACEHBI cohort","title_match":true,"year":2026},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/timedependent-biomarker-accuracy-in-forecasting-mild-cognitive-41433380","doi":"10.1002/alz70862_110285","journal":"Alzheimer s & Dementia","n_participants":102,"pmid":"41433380","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12725005/","study_design":"longitudinal study","title":"Time\u2010dependent biomarker accuracy in forecasting mild cognitive impairment","title_match":false,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/neuroprotective-antioxidant-and-anti-inflammatory-effect-of-greek-40427737","doi":"10.3390/biology14050548","journal":"Biology","n_participants":null,"pmid":"40427737","source_url":"https://pubmed.ncbi.nlm.nih.gov/40427737/","study_design":null,"title":"Neuroprotective, Antioxidant and Anti-Inflammatory Effect of Greek Pomegranate Seed Oil on N2a Neuroblastoma Cells and Mild Cognitive Impairment Patients","title_match":false,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/repeated-plasma-ptau217-measurements-to-monitor-clinical-progression-40442871","doi":"10.1002/alz.70319","journal":"Alzheimer s & Dementia","n_participants":186,"pmid":"40442871","source_url":"https://pubmed.ncbi.nlm.nih.gov/40442871/","study_design":"longitudinal study","title":"Repeated plasma p\u2010tau217 measurements to monitor clinical progression heterogeneity","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/what-does-a-positive-alzheimer-disease-blood-based-biomarker-result-42081782","doi":"10.1212/wnl.0000000000214953","journal":"Neurology","n_participants":null,"pmid":"42081782","source_url":"https://pubmed.ncbi.nlm.nih.gov/42081782/","study_design":null,"title":"What Does a Positive Alzheimer Disease Blood-Based Biomarker Result Mean in People With Mild Cognitive Impairment?","title_match":true,"year":2026},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/blood-level-of-amyloid-tau-and-p-tau-in-mild-cognitive-impairment-and-41949144","doi":"10.25259/ijmr_2164_2025","journal":"The Indian Journal of Medical Research","n_participants":96,"pmid":"41949144","source_url":"https://pubmed.ncbi.nlm.nih.gov/41949144/","study_design":null,"title":"Blood level of \u03b2-amyloid, Tau, and p-Tau in mild cognitive impairment and Alzheimer disease: A follow up study","title_match":false,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/diagnostic-value-and-difference-of-quantitative-susceptibility-40671196","doi":"10.1097/cm9.0000000000003683","journal":"Chinese Medical Journal","n_participants":20,"pmid":"40671196","source_url":"https://pubmed.ncbi.nlm.nih.gov/40671196/","study_design":"longitudinal study","title":"Diagnostic value and difference of quantitative susceptibility mapping and voxel-based morphological analysis in patients with Alzheimer\u2019s disease and mild cognitive impairment","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/ginkgo-biloba-and-longitudinal-changes-in-amyloid-pet-and-plasma-41984497","doi":"10.1177/13872877261441816","journal":"Journal of Alzheimer s Disease","n_participants":21,"pmid":"41984497","source_url":"https://pubmed.ncbi.nlm.nih.gov/41984497/","study_design":"cohort study","title":"Ginkgo biloba and longitudinal changes in amyloid PET and plasma amyloid-\u03b2 oligomerization in amyloid-positive mild cognitive impairment: A retrospective analysis","title_match":true,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/low-csf-app-refines-diagnosis-for-p-tau-negative-alzheimerlike-41444444","doi":"10.1002/alz70856_099406","journal":"Alzheimer s & Dementia","n_participants":384,"pmid":"41444444","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12738188/","study_design":null,"title":"Low CSF APP refines diagnosis for p \u2010tau negative Alzheimer\u2010like dementia","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/mosaic-loss-of-chromosome-y-and-plasma-a42-ptau181-ratio-as-dff7ac55","doi":"10.1002/alz70856_106620","journal":"Alzheimer s & Dementia","n_participants":30,"pmid":null,"source_url":"https://doi.org/10.1002/alz70856_106620","study_design":null,"title":"Mosaic Loss of Chromosome Y and Plasma A\u03b242/p\u2010tau181 Ratio as Biomarkers for Alzheimer's Disease in the Midwestern Amish","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/biomarcadores-sanguineos-no-diagnostico-precoce-da-doenca-de-6b1605e3","doi":"10.70773/revistatopicos/789452327","journal":"Revista T\u00f3picos.","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.70773/revistatopicos/789452327","study_design":null,"title":"BIOMARCADORES SANGU\u00cdNEOS NO DIAGN\u00d3STICO PRECOCE DA DOEN\u00c7A DE ALZHEIMER: UMA REVIS\u00c3O INTEGRATIVA","title_match":false,"year":2026},{"alzhub_score":25,"alzhub_url":"https://alzhub.org/study/avaliacao-do-papel-da-proteina-tau-no-diagnostico-precoce-e-4fb38053","doi":"10.55892/jrg.v8i19.2722","journal":"Revista JRG de Estudos Acad\u00eamicos","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.55892/jrg.v8i19.2722","study_design":null,"title":"Avalia\u00e7\u00e3o do Papel da Prote\u00edna Tau no Diagn\u00f3stico Precoce e Monitoramento do Alzheimer","title_match":false,"year":2025},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/the-evolving-roles-of-imaging-and-fluid-biomarkers-for-alzheimer-41447680","doi":"10.1002/alz70856_101336","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41447680","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12740309/","study_design":null,"title":"The evolving roles of imaging and fluid biomarkers for Alzheimer disease over the past quarter century","title_match":false,"year":2025},{"alzhub_score":26,"alzhub_url":"https://alzhub.org/study/biomarcadores-plasmaticos-na-deteccao-precoce-da-doenca-de-alzheimer-2f67a768","doi":"10.71248/22q77383","journal":"Cognitus Interdisciplinary Journal","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.71248/22q77383","study_design":null,"title":"BIOMARCADORES PLASM\u00c1TICOS NA DETEC\u00c7\u00c3O PRECOCE DA DOEN\u00c7A DE ALZHEIMER: UMA REVIS\u00c3O SISTEM\u00c1TICA","title_match":false,"year":2025},{"alzhub_score":28,"alzhub_url":"https://alzhub.org/study/revisao-sistematica-biomarcadores-sericos-no-diagnostico-precoce-da-017989b6","doi":"10.33448/rsd-v15i6.51180","journal":"Research Society and Development","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.33448/rsd-v15i6.51180","study_design":null,"title":"Revis\u00e3o sistem\u00e1tica: Biomarcadores s\u00e9ricos no diagn\u00f3stico precoce da doen\u00e7a de Alzheimer","title_match":false,"year":2026},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/7-fda-approved-csf-biomarkers-demonstrate-strong-predictive-value-for-dd3a1324","doi":"10.1093/ajcp/aqaf121.434","journal":"American Journal of Clinical Pathology","n_participants":40,"pmid":null,"source_url":"https://doi.org/10.1093/ajcp/aqaf121.434","study_design":null,"title":"7 FDA Approved CSF Biomarkers Demonstrate Strong Predictive Value for Identification of Alzheimer Disease Based on PET Scan in Patients with Standalone Alzheimer Cognitive Screening Tests","title_match":false,"year":2025},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/analogos-do-glp-1-na-doenca-de-alzheimer-potencial-neuroprotetor-alem-a57b2ca0","doi":"10.55905/rdelosv18.n75-128","journal":"DELOS Desarrollo Local Sostenible","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.55905/rdelosv18.n75-128","study_design":null,"title":"An\u00e1logos do glp-1 na doen\u00e7a de alzheimer: potencial neuroprotetor al\u00e9m do controle glic\u00eamico uma revis\u00e3o narrativa","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/biomarkers-of-underlying-alzheimer-disease-pathology-neuro-80aa2d8b","doi":"10.1093/ageing/afaf318.009","journal":"Age and Ageing","n_participants":333,"pmid":null,"source_url":"https://doi.org/10.1093/ageing/afaf318.009","study_design":null,"title":"Biomarkers of Underlying Alzheimer Disease Pathology & Neuro-inflammation, But Not Peripheral Inflammation, Predict Disease Clinically-Significant Progression in Mild-Moderate Alzheimer's Disease","title_match":false,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/from-clinical-judgment-to-biology-a-clinician-s-opinion-on-the-use-of-42028213","doi":"10.3389/fneur.2026.1804163","journal":"Frontiers in Neurology","n_participants":null,"pmid":"42028213","source_url":"https://pubmed.ncbi.nlm.nih.gov/42028213/","study_design":null,"title":"From clinical judgment to biology: a clinician's opinion on the use of blood-based biomarkers in Alzheimer's disease","title_match":true,"year":2026},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/is-tau-acetylation-a-key-to-frontotemporal-lobar-degeneration-42504910","doi":"10.1093/clinchem/hvag090","journal":"Clinical Chemistry","n_participants":null,"pmid":"42504910","source_url":"https://pubmed.ncbi.nlm.nih.gov/42504910/","study_design":null,"title":"Is Tau Acetylation a Key to Frontotemporal Lobar Degeneration Diagnosis?","title_match":false,"year":2026},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-biomarkers-including-tau-protein-and-amyloid-beta-c96d34e2","doi":"10.33545/26174693.2025.v9.i5c.7574","journal":"International Journal of Advanced Biochemistry Research","n_participants":62,"pmid":null,"source_url":"https://doi.org/10.33545/26174693.2025.v9.i5c.7574","study_design":null,"title":"Cerebrospinal fluid biomarkers including tau protein and amyloid-beta 42 for early detection and differential diagnosis of Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/blood-based-analysis-of-different-tau-variants-in-patients-with-a544b959","doi":"10.25673/123000","journal":"Digitalen Hochschulbibliothek Sachsen-Anhalt (Universit\u00e4ts- und Landesbibliothek Sachsen-Anhalt)","n_participants":27,"pmid":null,"source_url":"https://doi.org/10.25673/123000","study_design":null,"title":"Blood-based analysis of different tau variants in patients with multiple traumatic injuries","title_match":false,"year":2026},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/neurological-and-inflammatory-biomarkers-in-csf-along-the-alzheimer-s-41442429","doi":"10.1002/alz70856_097201","journal":"Alzheimer s & Dementia","n_participants":100,"pmid":"41442429","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12733682/","study_design":null,"title":"Neurological and inflammatory biomarkers in CSF along the Alzheimer's Disease spectrum","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/association-of-graph-network-properties-with-alzheimer-s-pathological-41447546","doi":"10.1002/alz70856_099727","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41447546","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12740131/","study_design":"longitudinal study","title":"Association of graph network properties with Alzheimer's pathological hallmarks early in the disease continuum","title_match":false,"year":2025},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/hat-nano-vang-vo-ong-va-sinh-pham-tai-to-hop-trien-vong-cho-xet-fcc626d3","doi":"10.58490/ctjump.2026i94.4307","journal":"T\u1ea1p ch\u00ed Y D\u01b0\u1ee3c h\u1ecdc C\u1ea7n Th\u01a1","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.58490/ctjump.2026i94.4307","study_design":null,"title":"H\u1ea0T NANO V\u00c0NG V\u1ece \u0110\u1ed2NG V\u00c0 SINH PH\u1ea8M T\u00c1I T\u1ed4 H\u1ee2P: TRI\u1ec2N V\u1eccNG CHO X\u00c9T NGHI\u1ec6M NHANH \u0110\u1ed8 NH\u1ea0Y CAO","title_match":false,"year":2026},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/biomarcadores-bioquimicos-emergentes-para-el-diagnostico-temprano-de-3ccbcb1b","doi":"10.56519/40dkrq29","journal":"Revista Polit\u00e9cnica de la Ciencia","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.56519/40dkrq29","study_design":null,"title":"BIOMARCADORES BIOQU\u00cdMICOS EMERGENTES PARA EL DIAGN\u00d3STICO TEMPRANO DE ENFERMEDADES NEURODEGENERATIVAS: REVISI\u00d3N SISTEM\u00c1TICA","title_match":false,"year":2026},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/biomarcadores-para-diagnostico-e-prognostico-de-doencas-c6ae3976","doi":"10.11606/issn.1679-9836.v104i3.esp.e-236262","journal":"Revista de Medicina","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.11606/issn.1679-9836.v104i3.esp.e-236262","study_design":null,"title":"Biomarcadores para diagn\u00f3stico e progn\u00f3stico de doen\u00e7as neurodegenerativas: uma revis\u00e3o de literatura","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/deep-medullary-vein-abnormalities-associated-with-cognitive-function-41434411","doi":"10.1002/alz70860_102602","journal":"Alzheimer s & Dementia","n_participants":903,"pmid":"41434411","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12725884/","study_design":"cross-sectional","title":"Deep medullary vein abnormalities associated with cognitive function and Alzheimer's disease plasma biomarkers in dementia\u2010free older adults: The MIND\u2010China Study","title_match":true,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/gamma-sensory-stimulation-in-mild-alzheimer-s-dementia-an-openlabel-41137616","doi":"10.1002/alz.70792","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41137616","source_url":"https://pubmed.ncbi.nlm.nih.gov/41137616/","study_design":"longitudinal study","title":"Gamma sensory stimulation in mild Alzheimer's dementia: An open\u2010label extension study","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/individualized-prediction-of-clinical-progression-to-dementia-using-41339948","doi":"10.1186/s13195-025-01925-1","journal":"Alzheimer s Research & Therapy","n_participants":184,"pmid":"41339948","source_url":"https://pubmed.ncbi.nlm.nih.gov/41339948/","study_design":null,"title":"Individualized prediction of clinical progression to dementia using plasma biomarkers in non-demented elderly","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/serum-level-changes-of-the-synaptic-marker-beta-synuclein-in-40571405","doi":"10.1136/jnnp-2025-336189","journal":"Journal of Neurology Neurosurgery & Psychiatry","n_participants":56,"pmid":"40571405","source_url":"https://pubmed.ncbi.nlm.nih.gov/40571405/","study_design":null,"title":"Serum level changes of the synaptic marker beta-synuclein in Alzheimer\u2019s disease continuum and other dementias","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/impact-of-cerebral-small-vessel-disease-on-cognitive-outcomes-in-41085237","doi":"10.1002/alz.70773","journal":"Alzheimer s & Dementia","n_participants":168,"pmid":"41085237","source_url":"https://pubmed.ncbi.nlm.nih.gov/41085237/","study_design":null,"title":"Impact of cerebral small vessel disease on cognitive outcomes in early age at onset MCI and dementia: Findings from the DIASPORA study","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/potential-role-of-amyloid-on-the-association-between-orexin-a-and-40457423","doi":"10.1186/s13195-025-01770-2","journal":"Alzheimer s Research & Therapy","n_participants":25,"pmid":"40457423","source_url":"https://pubmed.ncbi.nlm.nih.gov/40457423/","study_design":null,"title":"Potential role of Amyloid-\u03b2 on the association between Orexin-A and blood-brain barrier leakage of globus pallidus in Alzheimer\u2019s disease and dementia with lewy bodies","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/csf-acetylated-tau174-as-a-novel-diagnostic-and-prognostic-biomarker-41434517","doi":"10.1002/alz70861_108639","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41434517","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12725880/","study_design":null,"title":"CSF Acetylated Tau\u2010174 as a novel diagnostic and prognostic biomarker in Frontotemporal Dementia and Alzheimer\u2019s Disease","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/pet-and-blood-biomarkers-as-predictors-of-shortterm-progression-in-41447122","doi":"10.1002/alz70856_100227","journal":"Alzheimer s & Dementia","n_participants":42,"pmid":"41447122","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12739722/","study_design":null,"title":"PET and Blood Biomarkers as Predictors of Short\u2010Term Progression in MCI and Mild Dementia: Prospective Insights from a Southeast Asian Middle\u2010Income Country","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/associations-of-plasma-ptau231-with-serial-position-recall-40986437","doi":"10.1111/jnp.70012","journal":"Journal of Neuropsychology","n_participants":327,"pmid":"40986437","source_url":"https://pubmed.ncbi.nlm.nih.gov/40986437/","study_design":null,"title":"Associations of plasma p\u2010tau231 with serial position recall performance in free\u2010of\u2010dementia individuals","title_match":false,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/bdnf-val66met-genotype-dna-methylation-mrna-and-protein-levels-as-41009553","doi":"10.3390/ijms26188987","journal":"International Journal of Molecular Sciences","n_participants":null,"pmid":"41009553","source_url":"https://pubmed.ncbi.nlm.nih.gov/41009553/","study_design":null,"title":"BDNF Val66Met Genotype, DNA Methylation, mRNA, and Protein Levels as Potential Blood-Based Biomarkers for Dementia and Cognitive Decline","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/alzheimers-disease-diagnosis-among-dementia-patients-via-blood-40025636","doi":"10.1097/cm9.0000000000003496","journal":"Chinese Medical Journal","n_participants":156,"pmid":"40025636","source_url":"https://pubmed.ncbi.nlm.nih.gov/40025636/","study_design":null,"title":"Alzheimer\u2019s disease diagnosis among dementia patients via blood biomarker measurement based on the AT(N) system","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/safety-and-effectiveness-of-lecanemab-in-chinese-patients-with-early-41069006","doi":"10.1097/cm9.0000000000003888","journal":"Chinese Medical Journal","n_participants":64,"pmid":"41069006","source_url":"https://pubmed.ncbi.nlm.nih.gov/41069006/","study_design":null,"title":"Safety and effectiveness of lecanemab in Chinese patients with early Alzheimer\u2019s disease: Evidence from a multidimensional real-world study","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/estimating-cognitive-function-score-from-mild-cognitive-impairment-to-41823065","doi":"10.1177/13872877261429861","journal":"Journal of Alzheimer s Disease","n_participants":75,"pmid":"41823065","source_url":"https://pubmed.ncbi.nlm.nih.gov/41823065/","study_design":null,"title":"Estimating cognitive function score from mild cognitive impairment to moderate dementia using a hybrid model combining plasma biomarkers with electroencephalogram signal","title_match":true,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/plasma-nfl-and-gfap-in-the-preclinical-stages-of-neurodegenerative-41206819","doi":"10.1007/s00415-025-13498-y","journal":"Journal of Neurology","n_participants":1196,"pmid":"41206819","source_url":"https://pubmed.ncbi.nlm.nih.gov/41206819/","study_design":null,"title":"Plasma NfL and GFAP in the preclinical stages of neurodegenerative diseases: insights from the UK Biobank","title_match":true,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/objective-physical-activity-and-alzheimer-s-disease-burden-in-the-40965463","doi":"10.1002/alz.70655","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40965463","source_url":"https://pubmed.ncbi.nlm.nih.gov/40965463/","study_design":null,"title":"Objective physical activity and Alzheimer's disease burden in the population\u2010based Rotterdam Study","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/integrated-roles-of-systemic-diseases-and-serum-biomarkers-in-the-f0768c81","doi":"10.1002/mdb2.70008","journal":"Medicine Bulletin","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1002/mdb2.70008","study_design":null,"title":"Integrated Roles of Systemic Diseases and Serum Biomarkers in the Incidence of Age\u2010Related Macular Degeneration: The UK Biobank Study","title_match":true,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-distinguish-boston-criteria-2-0-cerebral-amyloid-40156276","doi":"10.1002/alz.70010","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40156276","source_url":"https://pubmed.ncbi.nlm.nih.gov/40156276/","study_design":null,"title":"Plasma biomarkers distinguish Boston Criteria 2.0 cerebral amyloid angiopathy from healthy controls","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/tdp-43-seeding-activity-in-the-olfactory-mucosa-of-patients-with-40287755","doi":"10.1186/s13024-025-00833-0","journal":"Molecular Neurodegeneration","n_participants":65,"pmid":"40287755","source_url":"https://pubmed.ncbi.nlm.nih.gov/40287755/","study_design":null,"title":"TDP-43 seeding activity in the olfactory mucosa of patients with amyotrophic lateral sclerosis","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/the-increase-in-tdp-43-and-neurogranin-blood-levels-at-different-40518820","doi":"10.1177/13872877251350385","journal":"Journal of Alzheimer s Disease","n_participants":234,"pmid":"40518820","source_url":"https://pubmed.ncbi.nlm.nih.gov/40518820/","study_design":null,"title":"The increase in TDP-43 and neurogranin blood levels at different stages of cognitive impairment in the elderly people: A cross-sectional study","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/serum-neurofilament-light-is-superior-to-glial-fibrillary-acidic-40486666","doi":"10.1136/bmjno-2024-001007","journal":"BMJ Neurology Open","n_participants":275,"pmid":"40486666","source_url":"https://pubmed.ncbi.nlm.nih.gov/40486666/","study_design":null,"title":"Serum neurofilament light is superior to glial fibrillary acidic protein to distinguish sporadic frontotemporal dementia from late-onset primary psychiatric disorders: a retrospective DIPPA-FTD study","title_match":false,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/trajectory-of-plasma-lipidome-associated-with-the-risk-of-late-onset-40592256","doi":"10.1016/j.ebiom.2025.105826","journal":"EBioMedicine","n_participants":1393,"pmid":"40592256","source_url":"https://pubmed.ncbi.nlm.nih.gov/40592256/","study_design":"cross-sectional","title":"Trajectory of plasma lipidome associated with the risk of late-onset Alzheimer's disease: a longitudinal cohort study","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/neurofilament-biomarkers-in-neurology-from-neuroinflammation-to-41097004","doi":"10.3390/ijms26199739","journal":"International Journal of Molecular Sciences","n_participants":null,"pmid":"41097004","source_url":"https://pubmed.ncbi.nlm.nih.gov/41097004/","study_design":"narrative review","title":"Neurofilament Biomarkers in Neurology: From Neuroinflammation to Neurodegeneration, Bridging Established and Novel Analytical Advances with Clinical Practice","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-of-amyloid-tau-neuroinflammation-in-alzheimers-40314736","doi":"10.1007/s00406-025-02013-z","journal":"European Archives of Psychiatry and Clinical Neuroscience","n_participants":27,"pmid":"40314736","source_url":"https://pubmed.ncbi.nlm.nih.gov/40314736/","study_design":null,"title":"Plasma biomarkers of amyloid, tau & neuroinflammation in Alzheimer\u2019s disease and corticobasal syndrome","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/microglia-as-a-key-player-in-arelated-astrocyte-reactivity-41449556","doi":"10.1002/alz70856_102677","journal":"Alzheimer s & Dementia","n_participants":62,"pmid":"41449556","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12740987/","study_design":null,"title":"Microglia as a key player in A\u03b2\u2010related astrocyte reactivity","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/targeting-the-mir965p-cathepsin-b-pathway-to-alleviate-neuronderived-40919134","doi":"10.1002/mco2.70368","journal":"MedComm","n_participants":null,"pmid":"40919134","source_url":"https://pubmed.ncbi.nlm.nih.gov/40919134/","study_design":null,"title":"Targeting the miR\u201096\u20105p/Cathepsin B Pathway to Alleviate Neuron\u2010Derived Neuroinflammation in Alzheimer's Disease","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-association-of-alzheimer-s-disease-and-related-dementias-41476029","doi":"10.1002/alz.71007","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41476029","source_url":"https://pubmed.ncbi.nlm.nih.gov/41476029/","study_design":"cross-sectional","title":"The association of Alzheimer's disease and related dementias blood\u2010based biomarkers with depressive symptoms","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/detecting-amyloid-and-tau-pathology-in-parkinsons-disease-4r-40895094","doi":"10.3389/fneur.2025.1638852","journal":"Frontiers in Neurology","n_participants":18,"pmid":"40895094","source_url":"https://pubmed.ncbi.nlm.nih.gov/40895094/","study_design":null,"title":"Detecting amyloid and tau pathology in Parkinson\u2019s disease, 4R-tauopathies and control subjects with plasma pTau217","title_match":true,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/neuropathologic-changes-in-people-with-essential-tremor-with-dementia-41160795","doi":"10.1212/wnl.0000000000214310","journal":"Neurology","n_participants":40,"pmid":"41160795","source_url":"https://pubmed.ncbi.nlm.nih.gov/41160795/","study_design":"cohort study","title":"Neuropathologic Changes in People With Essential Tremor With Dementia","title_match":false,"year":2025},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/plasma-mtbr-tau243-biomarker-identifies-tau-tangle-pathology-in-40164726","doi":"10.1038/s41591-025-03617-7","journal":"Nature Medicine","n_participants":108,"pmid":"40164726","source_url":"https://pubmed.ncbi.nlm.nih.gov/40164726/","study_design":null,"title":"Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer\u2019s disease","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/plasma-vesicle-associated-membrane-protein-2-and-glial-fibrillary-40620474","doi":"10.1093/braincomms/fcaf207","journal":"Brain Communications","n_participants":49,"pmid":"40620474","source_url":"https://pubmed.ncbi.nlm.nih.gov/40620474/","study_design":"cross-sectional","title":"Plasma vesicle-associated membrane protein 2 and glial fibrillary acidic protein associate with synaptic density in older adults without dementia","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/pathological-mechanisms-and-treatment-progression-of-alzheimers-40660381","doi":"10.1186/s40001-025-02886-9","journal":"European journal of medical research","n_participants":null,"pmid":"40660381","source_url":"https://pubmed.ncbi.nlm.nih.gov/40660381/","study_design":null,"title":"Pathological mechanisms and treatment progression of Alzheimer\u2019s disease","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/the-role-of-blood-based-biomarkers-in-transforming-alzheimers-disease-40943483","doi":"10.3390/ijms26178564","journal":"International Journal of Molecular Sciences","n_participants":null,"pmid":"40943483","source_url":"https://pubmed.ncbi.nlm.nih.gov/40943483/","study_design":"narrative review","title":"The Role of Blood-Based Biomarkers in Transforming Alzheimer\u2019s Disease Research and Clinical Management: A Review","title_match":true,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/synaptic-markers-are-associated-with-cognitive-decline-after-40461705","doi":"10.1038/s41598-025-04319-3","journal":"Scientific Reports","n_participants":null,"pmid":"40461705","source_url":"https://pubmed.ncbi.nlm.nih.gov/40461705/","study_design":"longitudinal study","title":"Synaptic markers are associated with cognitive decline after accounting for amyloid burden among an at-risk Alzheimer\u2019s disease cohort","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/biofluid-biomarker-changes-following-treatment-with-sabirnetug-acu193-39955261","doi":"10.1016/j.tjpad.2025.100082","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":null,"pmid":"39955261","source_url":"https://pubmed.ncbi.nlm.nih.gov/39955261/","study_design":"clinical trial","title":"Biofluid biomarker changes following treatment with sabirnetug (ACU193) in INTERCEPT-AD, a phase 1 trial in early Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/associations-of-klotho-vs-heterozygosity-and-klotho-protein-with-40112321","doi":"10.1177/13872877251326199","journal":"Journal of Alzheimer s Disease","n_participants":223,"pmid":"40112321","source_url":"https://pubmed.ncbi.nlm.nih.gov/40112321/","study_design":null,"title":"Associations of KLOTHO-VS heterozygosity and \u03b1-Klotho protein with cerebrospinal fluid Alzheimer's disease biomarkers","title_match":false,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/cita-go-on-study-a-community-based-multidomain-lifestyle-intervention-40589624","doi":"10.3389/fnagi.2025.1539711","journal":"Frontiers in Aging Neuroscience","n_participants":1051,"pmid":"40589624","source_url":"https://pubmed.ncbi.nlm.nih.gov/40589624/","study_design":"randomized controlled trial","title":"CITA GO-ON study. A community based multidomain lifestyle intervention to prevent cognitive decline. Protocol design and recruitment process","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/dietdriven-metabolite-patterns-link-the-mind-diet-to-dementia-41434081","doi":"10.1002/alz70860_106699","journal":"Alzheimer s & Dementia","n_participants":1104,"pmid":"41434081","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12725016/","study_design":null,"title":"Diet\u2010Driven Metabolite Patterns Link the MIND Diet to Dementia Biomarkers","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/the-3-minute-diagnostic-confusion-assessment-method-severity-score-40331035","doi":"10.1016/j.bjao.2025.100398","journal":"BJA Open","n_participants":177,"pmid":"40331035","source_url":"https://pubmed.ncbi.nlm.nih.gov/40331035/","study_design":"cohort study","title":"The 3-Minute Diagnostic Confusion Assessment Method severity score correlates with the Delirium Rating Scale\u2013Revised\u201398 and with biomarkers of delirium","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/safety-tolerability-and-potential-biomarkers-of-vodobatinib-in-40939527","doi":"10.1016/j.parkreldis.2025.108020","journal":"Parkinsonism & Related Disorders","n_participants":null,"pmid":"40939527","source_url":"https://pubmed.ncbi.nlm.nih.gov/40939527/","study_design":null,"title":"Safety, tolerability and potential biomarkers of vodobatinib in patients with dementia with Lewy bodies","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/white-matter-hyperintensities-moderate-the-association-between-41144252","doi":"10.2337/dc25-1162","journal":"Diabetes Care","n_participants":112,"pmid":"41144252","source_url":"https://pubmed.ncbi.nlm.nih.gov/41144252/","study_design":"cross-sectional","title":"White Matter Hyperintensities Moderate the Association Between Diabetes and Non-AD Brain Atrophy","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/retinal-microvascular-dysfunction-in-mild-cognitive-impairment-41761865","doi":"10.1002/alz.71216","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41761865","source_url":"https://pubmed.ncbi.nlm.nih.gov/41761865/","study_design":null,"title":"Retinal microvascular dysfunction in mild cognitive impairment: Associations with cerebral small vessel disease, plasma biomarkers, and cognitive decline","title_match":true,"year":2026},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/biomarker-advancements-in-cerebral-small-vessel-disease-an-overview-40364622","doi":"10.4103/nrr.nrr-d-24-01329","journal":"Neural Regeneration Research","n_participants":null,"pmid":"40364622","source_url":"https://pubmed.ncbi.nlm.nih.gov/40364622/","study_design":null,"title":"Biomarker advancements in cerebral small vessel disease: An overview","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/independent-and-interactive-contributions-of-white-matter-41906163","doi":"10.1186/s13195-026-02038-z","journal":"Alzheimer s Research & Therapy","n_participants":null,"pmid":"41906163","source_url":"https://pubmed.ncbi.nlm.nih.gov/41906163/","study_design":null,"title":"Independent and interactive contributions of white matter hyperintensities and Alzheimer\u2019s disease imaging and plasma biomarkers to cognitive decline in older adults without dementia","title_match":true,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/incidental-covert-cerebral-small-vessel-disease-detection-and-b43f515c","doi":"10.36922/an.4841","journal":"Advanced Neurology","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.36922/an.4841","study_design":"longitudinal study","title":"Incidental covert cerebral small vessel disease: Detection and management","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/elevated-serum-inflammasome-adaptor-protein-asc-is-associated-with-41884592","doi":"10.1093/braincomms/fcag068","journal":"Brain Communications","n_participants":531,"pmid":"41884592","source_url":"https://pubmed.ncbi.nlm.nih.gov/41884592/","study_design":null,"title":"Elevated serum inflammasome adaptor protein ASC is associated with white matter hyperintensities in vascular cognitive impairment","title_match":false,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/the-role-of-tau-amyloid-and-neuroinflammation-in-the-association-40753006","doi":"10.1016/j.tjpad.2025.100300","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":583,"pmid":"40753006","source_url":"https://pubmed.ncbi.nlm.nih.gov/40753006/","study_design":"cross-sectional","title":"The role of Tau, amyloid-\u03b2 and neuroinflammation in the association between cognition and white matter hyperintensities in a southeast Asian cohort","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/cerebral-small-vessel-disease-burden-relates-to-cognitive-decline-via-41958244","doi":"10.1177/0271678x261437577","journal":"Journal of Cerebral Blood Flow & Metabolism","n_participants":1026,"pmid":"41958244","source_url":"https://pubmed.ncbi.nlm.nih.gov/41958244/","study_design":"cross-sectional","title":"Cerebral small vessel disease burden relates to cognitive decline via impaired amyloid clearance in the general population","title_match":false,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/association-of-plasma-gfap-and-nfl-in-middle-aged-adults-with-mri-41461058","doi":"10.1212/wnl.0000000000214481","journal":"Neurology","n_participants":null,"pmid":"41461058","source_url":"https://pubmed.ncbi.nlm.nih.gov/41461058/","study_design":"longitudinal study","title":"Association of Plasma GFAP and NfL in Middle-Aged Adults With MRI Markers of Cerebral Small Vessel Disease Later in Life","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/glymphatic-dysfunction-associates-with-regional-white-matter-42411051","doi":"10.1017/s0033291726105005","journal":"Psychological Medicine","n_participants":216,"pmid":"42411051","source_url":"https://pubmed.ncbi.nlm.nih.gov/42411051/","study_design":null,"title":"Glymphatic dysfunction associates with regional white matter hyperintensities and plasma amyloid-\u03b2 burden across the Alzheimer\u2019s disease continuum","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/performance-of-upper-arm-capillary-blood-collection-for-alzheimers-c6e9e809","doi":"10.64898/2026.08.13.26360406","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.13.26360406","study_design":null,"title":"Performance of upper-arm capillary blood collection for Alzheimers disease and central nervous system biomarkers: comparison of Tasso+ and venous plasma","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/alzheimers-disease-blood-biomarkers-reveal-proteomic-modules-of-ab713afc","doi":"10.64898/2026.08.14.26360394","journal":"medRxiv (preprint)","n_participants":11042,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.14.26360394","study_design":null,"title":"Alzheimers disease blood biomarkers reveal proteomic modules of disease progression","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/the-dementia-trials-accelerator-dta-a-uk-dementia-trials-ready-cohort-25fefcbf","doi":"10.64898/2026.08.14.26359869","journal":"medRxiv (preprint)","n_participants":10000,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.14.26359869","study_design":null,"title":"The Dementia Trials Accelerator (DTA): a UK dementia trials-ready cohort","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/plasma-inflammatory-biomarker-associations-with-alzheimers-disease-0c982ec3","doi":"10.64898/2026.08.12.26360207","journal":"medRxiv (preprint)","n_participants":261,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.12.26360207","study_design":"cross-sectional","title":"Plasma inflammatory biomarker associations with Alzheimers disease clinical stage and CSF biomarkers: evaluation of sex effects","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/adult-vaccination-history-and-plasma-biomarker-signatures-in-the-179bc140","doi":"10.64898/2026.08.24.26361238","journal":"medRxiv (preprint)","n_participants":192,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.24.26361238","study_design":"longitudinal study","title":"Adult Vaccination History and Plasma Biomarker Signatures in the Asymptomatic PREVENT-AD Cohort","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/genetic-associations-with-eeg-signatures-in-mild-cognitive-impairment-0f6728d2","doi":"10.64898/2026.08.25.26361294","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.25.26361294","study_design":null,"title":"Genetic associations with EEG signatures in mild cognitive impairment: insights into Alzheimer's disease pathophysiology","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/treatment-response-biomarkers-in-early-alzheimers-disease-59d29669","doi":"10.64898/2026.08.27.26361425","journal":"medRxiv (preprint)","n_participants":65,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.27.26361425","study_design":"longitudinal study","title":"Treatment response biomarkers in early Alzheimers disease: longitudinal trajectories, sample size estimates, and the impact of progression variability","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/big-tau-and-brain-derived-tau-reveal-peripheral-and-central-nervous-a46fba4d","doi":"10.64898/2026.08.27.26361202","journal":"medRxiv (preprint)","n_participants":81,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.27.26361202","study_design":null,"title":"Big tau and brain-derived tau reveal peripheral and central nervous system involvement in neuropathies","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/returning-apoe-and-ptau-217-results-the-esmarter-randomized-7a589453","doi":"10.64898/2026.08.27.26361535","journal":"medRxiv (preprint)","n_participants":216,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.27.26361535","study_design":null,"title":"Returning APOE and pTau-217 Results: the eSMARTER Randomized Noninferiority Clinical Trial","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/analytical-validation-and-amyloid-status-discrimination-of-a-high-fa2a3d2c","doi":"10.64898/2026.08.31.26361836","journal":"medRxiv (preprint)","n_participants":449,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.31.26361836","study_design":null,"title":"Analytical validation and amyloid-status discrimination of a high-throughput, research-use-only plasma p-Tau217 immunoassay","title_match":true,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/a-two-stage-plasma-biomarker-algorithm-reduces-amyloid-pet-use-and-7da4a6e3","doi":"10.64898/2026.02.03.26345302","journal":"Annals of clinical and translational neurology","n_participants":630,"pmid":null,"source_url":"https://doi.org/10.64898/2026.02.03.26345302","study_design":null,"title":"A Two-Stage Plasma Biomarker Algorithm Reduces Amyloid PET Use and the p-Tau217 Gray Zone","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/proteoform-resolved-neogfap-as-a-diagnostic-and-prognostic-biomarker-2ab27f16","doi":"10.64898/2026.09.01.26361845","journal":"medRxiv (preprint)","n_participants":57,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.01.26361845","study_design":null,"title":"Proteoform-resolved neoGFAP as a diagnostic and prognostic biomarker across the TBI--MCI--AD continuum in Veterans","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/ancestry-specific-effects-of-apoe-on-alzheimer-disease-endophenotypes-52d13682","doi":"10.64898/2026.03.23.26349095","journal":"medRxiv (preprint)","n_participants":2733,"pmid":null,"source_url":"https://doi.org/10.64898/2026.03.23.26349095","study_design":null,"title":"Ancestry-specific effects of APOE on Alzheimer Disease Endophenotypes","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/amyloid-independent-elevation-of-plasma-phosphorylated-tau-217-tracks-f0e62b39","doi":"10.64898/2026.09.09.26362677","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.09.26362677","study_design":null,"title":"Amyloid-Independent Elevation of Plasma phosphorylated tau-217 Tracks Neurodegenerative Risk in Tuberous Sclerosis Complex: Implications for mTOR-Targeted Intervention","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/a-national-survey-exploring-dementia-diagnostics-and-care-provisions-4bcb0cda","doi":"10.64898/2026.09.11.26362825","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.11.26362825","study_design":null,"title":"A National Survey Exploring Dementia Diagnostics and Care Provisions in Primary Care in England","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/plasma-proteomics-reveals-stage-dependent-biological-remodelling-in-531152d3","doi":"10.64898/2026.09.14.26362968","journal":"medRxiv (preprint)","n_participants":1035,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.14.26362968","study_design":"cross-sectional","title":"Plasma proteomics reveals stage-dependent biological remodelling in Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/development-and-external-validation-of-a-plasma-p-tau217-based-model-54b6b226","doi":"10.64898/2026.09.15.26363045","journal":"medRxiv (preprint)","n_participants":401,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.15.26363045","study_design":null,"title":"Development and External Validation of a Plasma p-tau217-Based Model for MCI-to-Dementia Progression","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/association-of-plasma-biomarkers-with-longitudinal-change-in-age-and-7bb89a73","doi":"10.64898/2026.09.11.26362869","journal":"medRxiv (preprint)","n_participants":818,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.11.26362869","study_design":"cross-sectional","title":"Association of plasma biomarkers with longitudinal change in age- and Alzheimer's disease-related brain atrophy patterns","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/a-longitudinal-study-of-age-related-traits-and-cognitive-function-the-1633fa73","doi":"10.64898/2026.09.17.26363351","journal":"medRxiv (preprint)","n_participants":3978,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.17.26363351","study_design":"prospective cohort","title":"A longitudinal study of age-related traits and cognitive function: The Collaborative Amish Aging and Memory Project (CAAMP)","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/clinical-and-attitudinal-outcomes-of-a-personalized-multimodal-4286e09f","doi":"10.64898/2026.09.19.26363495","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.19.26363495","study_design":null,"title":"Clinical and attitudinal outcomes of a personalized, multimodal lifestyle intervention for Alzheimer's disease prevention in high-risk, cognitively normal older adults in north Alabama: A pilot study","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/elevation-in-plasma-p-tau217-concentrations-among-blood-donors-an-81db28dc","doi":"10.64898/2026.09.23.26363733","journal":"medRxiv (preprint)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.23.26363733","study_design":"cross-sectional","title":"Elevation in Plasma p-tau217 Concentrations Among Blood Donors: An Exploratory Cross-Sectional Study","title_match":true,"year":2026},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/biomarker-based-diagnosis-and-care-pathways-for-alzheimer-s-disease-42538752","doi":"10.1111/ene.70668","journal":"European journal of neurology","n_participants":null,"pmid":"42538752","source_url":"https://pubmed.ncbi.nlm.nih.gov/42538752/","study_design":null,"title":"Biomarker-Based Diagnosis and Care Pathways for Alzheimer's Disease in the Era of Disease-Modifying Treatments: A Consensus Statement by Belgian Experts","title_match":false,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/comparison-of-a-multi-analyte-algorithmic-immunoassay-blood-test-with-42434607","doi":"10.1002/dad2.70420","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":192,"pmid":"42434607","source_url":"https://pubmed.ncbi.nlm.nih.gov/42434607/","study_design":"cross-sectional","title":"Comparison of a multi-analyte algorithmic immunoassay blood test with immunoprecipitation mass spectrometry for the detection of amyloid pathology","title_match":true,"year":2026},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/advancing-early-detection-of-alzheimer-disease-in-the-primary-care-41445935","doi":"10.1212/cpj.0000000000200568","journal":"Neurology. Clinical practice","n_participants":603,"pmid":"41445935","source_url":"https://pubmed.ncbi.nlm.nih.gov/41445935/","study_design":"cross-sectional","title":"Advancing Early Detection of Alzheimer Disease in the Primary Care Setting in the United States","title_match":false,"year":2026},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-blood-based-biomarker-testing-a-stakeholder-40170393","doi":"10.1177/13872877251329394","journal":"Journal of Alzheimer's disease : JAD","n_participants":12,"pmid":"40170393","source_url":"https://pubmed.ncbi.nlm.nih.gov/40170393/","study_design":null,"title":"Alzheimer's disease blood-based biomarker testing: A stakeholder-informed assessment of coverage considerations","title_match":true,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/unlocking-ocular-biomarkers-for-early-detection-of-alzheimer-s-disease-39968707","doi":"10.1002/alz.14567","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39968707","source_url":"https://pubmed.ncbi.nlm.nih.gov/39968707/","study_design":null,"title":"Unlocking ocular biomarkers for early detection of Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/current-diagnostic-pathways-for-alzheimer-s-disease-a-cross-sectional-37483324","doi":"10.3233/ADR230007","journal":"Journal of Alzheimer's disease reports","n_participants":6744,"pmid":"37483324","source_url":"https://pubmed.ncbi.nlm.nih.gov/37483324/","study_design":"cross-sectional","title":"Current Diagnostic Pathways for Alzheimer's Disease: A Cross-Sectional Real-World Study Across Six Countries","title_match":false,"year":2023},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/a-phase-2-double-blind-placebo-controlled-24-week-treatment-clinical-34044875","doi":"10.1186/s13195-021-00843-2","journal":"Alzheimer's research & therapy","n_participants":464,"pmid":"34044875","source_url":"https://pubmed.ncbi.nlm.nih.gov/34044875/","study_design":"clinical trial","title":"A phase 2 double-blind placebo-controlled 24-week treatment clinical study of the p38 alpha kinase inhibitor neflamapimod in mild Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/plasma-proteomics-for-the-identification-of-alzheimer-disease-23314060","doi":"10.1097/wad.0b013e31827b60d2","journal":"Alzheimer disease and associated disorders","n_participants":109,"pmid":"23314060","source_url":"https://pubmed.ncbi.nlm.nih.gov/23314060/","study_design":"randomized controlled trial","title":"Plasma proteomics for the identification of Alzheimer disease","title_match":false,"year":2013},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/a-genome-wide-association-meta-analysis-of-plasma-a-peptides-24535457","doi":"10.1038/mp.2013.185","journal":"Molecular psychiatry","n_participants":null,"pmid":"24535457","source_url":"https://pubmed.ncbi.nlm.nih.gov/24535457/","study_design":"meta-analysis","title":"A genome-wide association meta-analysis of plasma A\u03b2 peptides concentrations in the elderly","title_match":true,"year":2014},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/17beta-estradiol-reduces-plasma-abeta40-for-hrt-naive-postmenopausal-12611754","doi":"10.1097/00019442-200303000-00015","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":null,"pmid":"12611754","source_url":"https://pubmed.ncbi.nlm.nih.gov/12611754/","study_design":"randomized controlled trial","title":"17beta-estradiol reduces plasma Abeta40 for HRT-na\u00efve postmenopausal women with Alzheimer disease: a preliminary study","title_match":true,"year":2003},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/plasma-levels-of-abeta42-and-abeta40-in-alzheimer-patients-during-12218259","doi":"10.1159/000063605","journal":"Dementia and geriatric cognitive disorders","n_participants":null,"pmid":"12218259","source_url":"https://pubmed.ncbi.nlm.nih.gov/12218259/","study_design":"clinical trial","title":"Plasma levels of Abeta42 and Abeta40 in Alzheimer patients during treatment with the acetylcholinesterase inhibitor tacrine","title_match":false,"year":2002},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/neurobiological-correlates-of-mild-behavioral-impairment-a-systematic-41121344","doi":"10.1186/s13195-025-01874-9","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"41121344","source_url":"https://pubmed.ncbi.nlm.nih.gov/41121344/","study_design":"systematic review","title":"Neurobiological correlates of Mild Behavioral Impairment: a systematic review and meta-analysis","title_match":false,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/phase-3-randomized-clinical-trials-of-simufilam-in-mild-to-moderate-41500915","doi":"10.1016/j.tjpad.2025.100469","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"41500915","source_url":"https://pubmed.ncbi.nlm.nih.gov/41500915/","study_design":"post-hoc analysis","title":"Phase 3 randomized clinical trials of simufilam in mild-to-moderate Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/plasma-gfap-outperforms-csf-gfap-in-detecting-amyloid-pathology-and-41905188","doi":"10.1016/j.tjpad.2026.100544","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"41905188","source_url":"https://pubmed.ncbi.nlm.nih.gov/41905188/","study_design":"longitudinal study","title":"Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associated with increased risk of clinical progression in early Alzheimer's disease","title_match":true,"year":2026},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/impact-of-zervimesine-on-the-neuroinflammatory-biomarker-gfap-and-41943055","doi":"10.1186/s13195-026-02025-4","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"41943055","source_url":"https://pubmed.ncbi.nlm.nih.gov/41943055/","study_design":"clinical trial","title":"Impact of zervimesine on the neuroinflammatory biomarker GFAP and related proteomic molecular correlates in plasma of participants from a phase 2 clinical trial in Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/neuroinflammatory-fluid-biomarkers-in-patients-with-alzheimer-s-40050444","doi":"10.1038/s41380-025-02939-9","journal":"Molecular psychiatry","n_participants":null,"pmid":"40050444","source_url":"https://pubmed.ncbi.nlm.nih.gov/40050444/","study_design":"meta-analysis","title":"Neuroinflammatory fluid biomarkers in patients with Alzheimer's disease: a systematic literature review","title_match":false,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/minocycline-for-sporadic-and-hereditary-cerebral-amyloid-angiopathy-37277877","doi":"10.1186/s13063-023-07371-4","journal":"Trials","n_participants":60,"pmid":"37277877","source_url":"https://pubmed.ncbi.nlm.nih.gov/37277877/","study_design":null,"title":"Minocycline for sporadic and hereditary cerebral amyloid angiopathy (BATMAN): study protocol for a placebo-controlled randomized double-blind trial","title_match":false,"year":2023},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/post-hoc-analysis-of-adamant-a-phase-2-clinical-trial-of-active-tau-39580468","doi":"10.1186/s13195-024-01620-7","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"39580468","source_url":"https://pubmed.ncbi.nlm.nih.gov/39580468/","study_design":"post-hoc analysis","title":"Post hoc analysis of ADAMANT, a phase 2 clinical trial of active tau immunotherapy with AADvac1 in patients with Alzheimer's disease, positive for plasma p-tau217","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-effect-of-apoe-4-on-alzheimer-s-disease-fluid-biomarkers-a-cross-39749650","doi":"10.1111/cns.70202","journal":"CNS neuroscience & therapeutics","n_participants":575,"pmid":"39749650","source_url":"https://pubmed.ncbi.nlm.nih.gov/39749650/","study_design":null,"title":"The Effect of APOE \u03b54 on Alzheimer's Disease Fluid Biomarkers: A Cross-Sectional Study Based on the COAST","title_match":false,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/plasma-mcp-1-and-changes-on-cognitive-function-in-community-dwelling-34996522","doi":"10.1186/s13195-021-00940-2","journal":"Alzheimer's research & therapy","n_participants":1097,"pmid":"34996522","source_url":"https://pubmed.ncbi.nlm.nih.gov/34996522/","study_design":"longitudinal study","title":"Plasma MCP-1 and changes on cognitive function in community-dwelling older adults","title_match":false,"year":2022},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/bioface-a-prospective-study-of-risk-factors-cognition-and-biomarkers-34420953","doi":"10.3233/jad-210254","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"34420953","source_url":"https://pubmed.ncbi.nlm.nih.gov/34420953/","study_design":null,"title":"BIOFACE: A Prospective Study of Risk Factors, Cognition, and Biomarkers in a Cohort of Individuals with Early-Onset Mild Cognitive Impairment. Study Rationale and Research Protocols","title_match":false,"year":2021},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/high-performance-plasma-amyloid-biomarkers-for-alzheimers-disease-29420472","doi":"10.1038/nature25456","journal":"Nature","n_participants":null,"pmid":"29420472","source_url":"https://pubmed.ncbi.nlm.nih.gov/29420472/","study_design":null,"title":"High performance plasma amyloid-\u03b2 biomarkers for Alzheimer\u2019s disease","title_match":true,"year":2018},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/biomarkers-for-neurodegenerative-diseases-34083813","doi":"10.1038/s41591-021-01382-x","journal":"Nature Medicine","n_participants":null,"pmid":"34083813","source_url":"https://pubmed.ncbi.nlm.nih.gov/34083813/","study_design":null,"title":"Biomarkers for neurodegenerative diseases","title_match":false,"year":2021},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/performance-of-plasma-phosphorylated-tau-181-and-217-in-the-community-35618838","doi":"10.1038/s41591-022-01822-2","journal":"Nature Medicine","n_participants":null,"pmid":"35618838","source_url":"https://pubmed.ncbi.nlm.nih.gov/35618838/","study_design":null,"title":"Performance of plasma phosphorylated tau 181 and 217 in the community","title_match":false,"year":2022},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/plasma-phosphotau181-increases-with-alzheimer-s-disease-clinical-29626426","doi":"10.1016/j.jalz.2018.02.013","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"29626426","source_url":"https://pubmed.ncbi.nlm.nih.gov/29626426/","study_design":null,"title":"Plasma phospho\u2010tau181 increases with Alzheimer's disease clinical severity and is associated with tau\u2010 and amyloid\u2010positron emission tomography","title_match":false,"year":2018},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/clinical-correlates-of-white-matter-findings-on-cranial-magnetic-8711786","doi":"10.1161/01.str.27.8.1274","journal":"Stroke","n_participants":null,"pmid":"8711786","source_url":"https://pubmed.ncbi.nlm.nih.gov/8711786/","study_design":null,"title":"Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study","title_match":false,"year":1996},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/clinical-and-biomarker-changes-of-alzheimer-s-disease-in-adults-with-32593336","doi":"10.1016/s0140-6736(20)30689-9","journal":"The Lancet","n_participants":null,"pmid":"32593336","source_url":"https://pubmed.ncbi.nlm.nih.gov/32593336/","study_design":null,"title":"Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study","title_match":false,"year":2020},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/differential-roles-of-a42-40-p-tau231-and-p-tau217-for-alzheimers-36456833","doi":"10.1038/s41591-022-02074-w","journal":"Nature Medicine","n_participants":null,"pmid":"36456833","source_url":"https://pubmed.ncbi.nlm.nih.gov/36456833/","study_design":null,"title":"Differential roles of A\u03b242/40, p-tau231 and p-tau217 for Alzheimer\u2019s trial selection and disease monitoring","title_match":true,"year":2022},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/sex-differences-in-alzheimer-s-disease-37030962","doi":"10.1016/j.ncl.2023.01.001","journal":"Neurologic clinics","n_participants":null,"pmid":"37030962","source_url":"https://pubmed.ncbi.nlm.nih.gov/37030962/","study_design":null,"title":"Sex Differences in Alzheimer's Disease","title_match":false,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/memory-and-plasma-ptau217-refine-prognosis-in-down-syndrome-42825390","doi":"10.1002/ana.78366","journal":"Annals of neurology","n_participants":null,"pmid":"42825390","source_url":"https://pubmed.ncbi.nlm.nih.gov/42825390/","study_design":null,"title":"Memory and Plasma pTau217 Refine Prognosis in Down Syndrome","title_match":true,"year":2026},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/onset-of-alzheimer-disease-in-apolipoprotein-4-carriers-is-earlier-in-2fcd5460","doi":"10.1101/2024.01.02.24300718","journal":"BMC neurology","n_participants":33,"pmid":null,"source_url":"https://doi.org/10.1101/2024.01.02.24300718","study_design":null,"title":"Onset of Alzheimer disease in apolipoprotein \u025b4 carriers is earlier in butyrylcholinesterase K variant carriers","title_match":false,"year":2024},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/diagnostic-performance-and-prediction-of-clinical-progression-of-01fa071e","doi":"10.1101/2020.07.15.20154237","journal":"Molecular psychiatry","n_participants":1000,"pmid":null,"source_url":"https://doi.org/10.1101/2020.07.15.20154237","study_design":"longitudinal study","title":"Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer\u2019s Disease Neuroimaging Initiative","title_match":false,"year":2020},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/clinical-factors-associated-with-discordant-plasma-p-tau217-and-42821845","doi":"10.1212/wnl.0000000000218591","journal":"Neurology","n_participants":706,"pmid":"42821845","source_url":"https://pubmed.ncbi.nlm.nih.gov/42821845/","study_design":null,"title":"Clinical Factors Associated With Discordant Plasma P-Tau217 and Established Alzheimer Disease Biomarkers","title_match":true,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/peritoneal-dialysis-reduces-amyloid-beta-plasma-levels-in-humans-and-28477083","doi":"10.1007/s00401-017-1721-y","journal":"Acta neuropathologica","n_participants":null,"pmid":"28477083","source_url":"https://pubmed.ncbi.nlm.nih.gov/28477083/","study_design":null,"title":"Peritoneal dialysis reduces amyloid-beta plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model","title_match":false,"year":2017},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/novel-blood-based-biomarkers-of-cognition-stress-and-physical-or-28731451","doi":"10.3233/jad-170447","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"28731451","source_url":"https://pubmed.ncbi.nlm.nih.gov/28731451/","study_design":null,"title":"Novel Blood-Based Biomarkers of Cognition, Stress, and Physical or Cognitive Training in Older Adults at Risk of Dementia: Preliminary Evidence for a Role of BDNF, Irisin, and the Kynurenine Pathway","title_match":true,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/individualized-clinical-management-of-patients-at-risk-for-alzheimer-31677936","doi":"10.1016/j.jalz.2019.08.198","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"31677936","source_url":"https://pubmed.ncbi.nlm.nih.gov/31677936/","study_design":null,"title":"Individualized clinical management of patients at risk for Alzheimer's dementia","title_match":false,"year":2019},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/synergic-trial-synchronizing-exercises-remedies-in-gait-and-cognition-29661156","doi":"10.1186/s12877-018-0782-7","journal":"BMC geriatrics","n_participants":null,"pmid":"29661156","source_url":"https://pubmed.ncbi.nlm.nih.gov/29661156/","study_design":null,"title":"SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment","title_match":false,"year":2018},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/plasma-a-and-neurofilament-light-chain-are-associated-with-cognitive-33032662","doi":"10.1186/s13195-020-00697-0","journal":"Alzheimer's research & therapy","n_participants":452,"pmid":"33032662","source_url":"https://pubmed.ncbi.nlm.nih.gov/33032662/","study_design":"cross-sectional","title":"Plasma A\u03b2 and neurofilament light chain are associated with cognitive and physical function decline in non-dementia older adults","title_match":true,"year":2020},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/genetic-architecture-of-plasma-amyloid-and-tau-biomarkers-in-the-amish-2f025e48","doi":"10.64898/2026.10.15.26365636","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.15.26365636","study_design":null,"title":"Genetic Architecture of Plasma Amyloid and Tau Biomarkers in the Amish","title_match":true,"year":2026},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/evidence-for-reduced-somatic-t-cell-receptor-sequence-diversity-42892741","doi":"10.1111/ahg.70063","journal":"Annals of human genetics","n_participants":72,"pmid":"42892741","source_url":"https://pubmed.ncbi.nlm.nih.gov/42892741/","study_design":"longitudinal study","title":"Evidence for Reduced Somatic T-Cell Receptor Sequence Diversity Profiles Among Midwestern Amish in an Aging Cohort Study","title_match":false,"year":2026},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/midlife-and-late-life-alzheimer-disease-blood-biomarkers-and-11-year-42886876","doi":"10.1212/wnl.0000000000218692","journal":"Neurology","n_participants":920,"pmid":"42886876","source_url":"https://pubmed.ncbi.nlm.nih.gov/42886876/","study_design":"prospective cohort","title":"Midlife and Late-Life Alzheimer Disease Blood Biomarkers and 11-Year Cognitive Decline","title_match":false,"year":2026},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/phosphorylated-tau-217-in-young-adults-with-down-syndrome-and-down-42897209","doi":"10.1038/s43856-026-01921-y","journal":"Communications medicine","n_participants":132,"pmid":"42897209","source_url":"https://pubmed.ncbi.nlm.nih.gov/42897209/","study_design":"longitudinal study","title":"Phosphorylated tau 217 in young adults with Down syndrome and Down syndrome regression disorder","title_match":false,"year":2026},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/diagnostic-and-prognostic-plasma-biomarkers-for-preclinical-alzheimer-34494715","doi":"10.1002/alz.12447","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"34494715","source_url":"https://pubmed.ncbi.nlm.nih.gov/34494715/","study_design":"longitudinal study","title":"Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease","title_match":true,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-tau-amyloid-1-42-ratio-predicts-brain-tau-deposition-and-30668647","doi":"10.1093/brain/awy347","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"30668647","source_url":"https://pubmed.ncbi.nlm.nih.gov/30668647/","study_design":"cross-sectional","title":"Plasma tau/amyloid-\u03b21-42 ratio predicts brain tau deposition and neurodegeneration in Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/causal-associations-between-modifiable-risk-factors-and-the-alzheimer-32996171","doi":"10.1002/ana.25918","journal":"Annals of neurology","n_participants":null,"pmid":"32996171","source_url":"https://pubmed.ncbi.nlm.nih.gov/32996171/","study_design":null,"title":"Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome","title_match":false,"year":2021},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/microrna-expression-in-extracellular-vesicles-as-a-novel-blood-based-37071449","doi":"10.1002/alz.13055","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37071449","source_url":"https://pubmed.ncbi.nlm.nih.gov/37071449/","study_design":null,"title":"MicroRNA expression in extracellular vesicles as a novel blood-based biomarker for Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/plasma-p-tau231-and-p-tau217-as-state-markers-of-amyloid-pathology-in-35953717","doi":"10.1038/s41591-022-01925-w","journal":"Nature medicine","n_participants":null,"pmid":"35953717","source_url":"https://pubmed.ncbi.nlm.nih.gov/35953717/","study_design":"longitudinal study","title":"Plasma p-tau231 and p-tau217 as state markers of amyloid-\u03b2 pathology in preclinical Alzheimer's disease","title_match":true,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-deposition-is-associated-with-increases-in-soluble-and-32426454","doi":"10.1126/sciadv.aaz2387","journal":"Science advances","n_participants":null,"pmid":"32426454","source_url":"https://pubmed.ncbi.nlm.nih.gov/32426454/","study_design":null,"title":"A\u03b2 deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/the-diagnostic-and-prognostic-capabilities-of-plasma-biomarkers-in-33491853","doi":"10.1002/alz.12283","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"33491853","source_url":"https://pubmed.ncbi.nlm.nih.gov/33491853/","study_design":"longitudinal study","title":"The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease","title_match":true,"year":2021},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/altered-bile-acid-profile-in-mild-cognitive-impairment-and-alzheimer-30337152","doi":"10.1016/j.jalz.2018.08.012","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1562,"pmid":"30337152","source_url":"https://pubmed.ncbi.nlm.nih.gov/30337152/","study_design":null,"title":"Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers","title_match":false,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/total-and-phosphorylated-tau-protein-as-biological-markers-of-19853650","doi":"10.1016/j.exger.2009.10.010","journal":"Experimental gerontology","n_participants":null,"pmid":"19853650","source_url":"https://pubmed.ncbi.nlm.nih.gov/19853650/","study_design":null,"title":"Total and phosphorylated tau protein as biological markers of Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/plasma-a42-40-ratio-p-tau181-gfap-and-nfl-across-the-alzheimer-s-36574591","doi":"10.1002/alz.12724","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":81,"pmid":"36574591","source_url":"https://pubmed.ncbi.nlm.nih.gov/36574591/","study_design":"cross-sectional","title":"Plasma A\u03b242/40 ratio, p-tau181, GFAP, and NfL across the Alzheimer's disease continuum: A cross-sectional and longitudinal study in the AIBL cohort","title_match":true,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/decreased-cerebrospinal-fluid-abeta-42-correlates-with-brain-atrophy-19260027","doi":"10.1002/ana.21559","journal":"Annals of neurology","n_participants":29,"pmid":"19260027","source_url":"https://pubmed.ncbi.nlm.nih.gov/19260027/","study_design":null,"title":"Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly","title_match":false,"year":2009},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-of-alzheimer-s-disease-improve-prediction-of-34117234","doi":"10.1038/s41467-021-23746-0","journal":"Nature communications","n_participants":null,"pmid":"34117234","source_url":"https://pubmed.ncbi.nlm.nih.gov/34117234/","study_design":null,"title":"Plasma biomarkers of Alzheimer's disease improve prediction of cognitive decline in cognitively unimpaired elderly populations","title_match":true,"year":2021},{"alzhub_score":81,"alzhub_url":"https://alzhub.org/study/lecanemab-in-patients-with-early-alzheimer-s-disease-detailed-results-36544184","doi":"10.1186/s13195-022-01124-2","journal":"Alzheimer's research & therapy","n_participants":856,"pmid":"36544184","source_url":"https://pubmed.ncbi.nlm.nih.gov/36544184/","study_design":"open-label trial","title":"Lecanemab in patients with early Alzheimer's disease: detailed results on biomarker, cognitive, and clinical effects from the randomized and open-label extension of the phase 2 proof-of-concept study","title_match":false,"year":2022},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/plasma-and-csf-biomarkers-in-a-memory-clinic-head-to-head-comparison-36370462","doi":"10.1002/alz.12841","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":197,"pmid":"36370462","source_url":"https://pubmed.ncbi.nlm.nih.gov/36370462/","study_design":null,"title":"Plasma and CSF biomarkers in a memory clinic: Head-to-head comparison of phosphorylated tau immunoassays","title_match":false,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/confounding-factors-of-alzheimer-s-disease-plasma-biomarkers-and-36152307","doi":"10.1002/alz.12787","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":748,"pmid":"36152307","source_url":"https://pubmed.ncbi.nlm.nih.gov/36152307/","study_design":null,"title":"Confounding factors of Alzheimer's disease plasma biomarkers and their impact on clinical performance","title_match":true,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-for-alzheimer-s-disease-in-relation-to-35195758","doi":"10.1007/s00401-022-02408-5","journal":"Acta neuropathologica","n_participants":null,"pmid":"35195758","source_url":"https://pubmed.ncbi.nlm.nih.gov/35195758/","study_design":null,"title":"Plasma biomarkers for Alzheimer's Disease in relation to neuropathology and cognitive change","title_match":true,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/head-to-head-comparison-of-leading-blood-tests-for-alzheimer-s-39394841","doi":"10.1002/alz.14315","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39394841","source_url":"https://pubmed.ncbi.nlm.nih.gov/39394841/","study_design":null,"title":"Head-to-head comparison of leading blood tests for Alzheimer's disease pathology","title_match":true,"year":2024},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/specific-associations-between-plasma-biomarkers-and-postmortem-36912178","doi":"10.15252/emmm.202217123","journal":"EMBO molecular medicine","n_participants":105,"pmid":"36912178","source_url":"https://pubmed.ncbi.nlm.nih.gov/36912178/","study_design":"longitudinal study","title":"Specific associations between plasma biomarkers and postmortem amyloid plaque and tau tangle loads","title_match":true,"year":2023},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/differential-levels-of-plasma-biomarkers-of-neurodegeneration-in-lewy-35078917","doi":"10.1136/jnnp-2021-327788","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":300,"pmid":"35078917","source_url":"https://pubmed.ncbi.nlm.nih.gov/35078917/","study_design":"longitudinal study","title":"Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy","title_match":true,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/clinical-and-analytical-comparison-of-six-simoa-assays-for-plasma-p-34863295","doi":"10.1186/s13195-021-00939-9","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"34863295","source_url":"https://pubmed.ncbi.nlm.nih.gov/34863295/","study_design":null,"title":"Clinical and analytical comparison of six Simoa assays for plasma P-tau isoforms P-tau181, P-tau217, and P-tau231","title_match":true,"year":2021},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/detecting-amyloid-positivity-in-early-alzheimer-s-disease-using-34151519","doi":"10.1002/alz.12395","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":591,"pmid":"34151519","source_url":"https://pubmed.ncbi.nlm.nih.gov/34151519/","study_design":null,"title":"Detecting amyloid positivity in early Alzheimer's disease using combinations of plasma A\u03b242/A\u03b240 and p-tau","title_match":true,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/csf-tau-phosphorylation-occupancies-at-t217-and-t205-represent-37117788","doi":"10.1038/s43587-023-00380-7","journal":"Nature aging","n_participants":263,"pmid":"37117788","source_url":"https://pubmed.ncbi.nlm.nih.gov/37117788/","study_design":null,"title":"CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/equivalence-of-plasma-p-tau217-with-cerebrospinal-fluid-in-the-37078495","doi":"10.1002/alz.13026","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":174,"pmid":"37078495","source_url":"https://pubmed.ncbi.nlm.nih.gov/37078495/","study_design":null,"title":"Equivalence of plasma p-tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-and-genetics-in-the-diagnosis-and-prediction-of-35383826","doi":"10.1093/brain/awac128","journal":"Brain : a journal of neurology","n_participants":1439,"pmid":"35383826","source_url":"https://pubmed.ncbi.nlm.nih.gov/35383826/","study_design":"case-control study","title":"Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-p-tau231-as-an-early-indicator-of-emerging-35158308","doi":"10.1016/j.ebiom.2022.103836","journal":"EBioMedicine","n_participants":171,"pmid":"35158308","source_url":"https://pubmed.ncbi.nlm.nih.gov/35158308/","study_design":null,"title":"Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease","title_match":true,"year":2022},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/an-accurate-fully-automated-panel-of-plasma-biomarkers-for-alzheimer-35950735","doi":"10.1002/alz.12751","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":920,"pmid":"35950735","source_url":"https://pubmed.ncbi.nlm.nih.gov/35950735/","study_design":null,"title":"An accurate fully automated panel of plasma biomarkers for Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/predicting-amyloid-pet-and-tau-pet-stages-with-plasma-biomarkers-36789483","doi":"10.1093/brain/awad042","journal":"Brain : a journal of neurology","n_participants":1136,"pmid":"36789483","source_url":"https://pubmed.ncbi.nlm.nih.gov/36789483/","study_design":null,"title":"Predicting amyloid PET and tau PET stages with plasma biomarkers","title_match":true,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-of-alzheimer-s-disease-a-review-of-available-assays-37220625","doi":"10.3233/adr-230029","journal":"Journal of Alzheimer's disease reports","n_participants":null,"pmid":"37220625","source_url":"https://pubmed.ncbi.nlm.nih.gov/37220625/","study_design":null,"title":"Plasma Biomarkers of Alzheimer's Disease: A Review of Available Assays, Recent Developments, and Implications for Clinical Practice","title_match":true,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/plasma-a42-a40-and-phospho-tau217-concentration-ratios-increase-the-37932961","doi":"10.1002/alz.13542","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37932961","source_url":"https://pubmed.ncbi.nlm.nih.gov/37932961/","study_design":null,"title":"Plasma A\u03b242/A\u03b240 and phospho-tau217 concentration ratios increase the accuracy of amyloid PET classification in preclinical Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/the-accuracy-and-robustness-of-plasma-biomarker-models-for-amyloid-35130933","doi":"10.1186/s13195-021-00942-0","journal":"Alzheimer's research & therapy","n_participants":50,"pmid":"35130933","source_url":"https://pubmed.ncbi.nlm.nih.gov/35130933/","study_design":null,"title":"The accuracy and robustness of plasma biomarker models for amyloid PET positivity","title_match":true,"year":2022},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-217-in-preclinical-alzheimer-s-disease-37013174","doi":"10.1093/braincomms/fcad057","journal":"Brain communications","n_participants":165,"pmid":"37013174","source_url":"https://pubmed.ncbi.nlm.nih.gov/37013174/","study_design":"cohort study","title":"Plasma phosphorylated tau 217 in preclinical Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/measurement-of-thirteen-biological-markers-in-csf-of-patients-with-16244482","doi":"10.1159/000089137","journal":"Dementia and geriatric cognitive disorders","n_participants":null,"pmid":"16244482","source_url":"https://pubmed.ncbi.nlm.nih.gov/16244482/","study_design":null,"title":"Measurement of thirteen biological markers in CSF of patients with Alzheimer's disease and other dementias","title_match":false,"year":2006},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/comparison-of-serum-neurodegenerative-biomarkers-among-hospitalized-35023610","doi":"10.1002/alz.12556","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":251,"pmid":"35023610","source_url":"https://pubmed.ncbi.nlm.nih.gov/35023610/","study_design":null,"title":"Comparison of serum neurodegenerative biomarkers among hospitalized COVID-19 patients versus non-COVID subjects with normal cognition, mild cognitive impairment, or Alzheimer's dementia","title_match":false,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/head-to-head-comparison-of-clinical-performance-of-csf-phospho-tau-33252199","doi":"10.1002/alz.12236","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":503,"pmid":"33252199","source_url":"https://pubmed.ncbi.nlm.nih.gov/33252199/","study_design":null,"title":"Head-to-head comparison of clinical performance of CSF phospho-tau T181 and T217 biomarkers for Alzheimer's disease diagnosis","title_match":false,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/mass-spectrometric-simultaneous-quantification-of-tau-species-in-37198279","doi":"10.1038/s43587-023-00405-1","journal":"Nature aging","n_participants":214,"pmid":"37198279","source_url":"https://pubmed.ncbi.nlm.nih.gov/37198279/","study_design":null,"title":"Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies","title_match":false,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-amyloid-42-40-ratio-in-clinical-setting-of-memory-26034513","doi":"10.1186/s13195-015-0114-5","journal":"Alzheimer's research & therapy","n_participants":367,"pmid":"26034513","source_url":"https://pubmed.ncbi.nlm.nih.gov/26034513/","study_design":null,"title":"Cerebrospinal fluid amyloid-\u03b2 42/40 ratio in clinical setting of memory centers: a multicentric study","title_match":false,"year":2015},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/markers-of-neuroinflammation-associated-with-alzheimer-s-disease-28161476","doi":"10.1016/j.bbi.2017.01.020","journal":"Brain, behavior, and immunity","n_participants":48,"pmid":"28161476","source_url":"https://pubmed.ncbi.nlm.nih.gov/28161476/","study_design":"cross-sectional","title":"Markers of neuroinflammation associated with Alzheimer's disease pathology in older adults","title_match":false,"year":2017},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/assay-of-plasma-phosphorylated-tau-protein-threonine-181-and-total-29376870","doi":"10.3233/jad-170810","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"29376870","source_url":"https://pubmed.ncbi.nlm.nih.gov/29376870/","study_design":null,"title":"Assay of Plasma Phosphorylated Tau Protein (Threonine 181) and Total Tau Protein in Early-Stage Alzheimer's Disease","title_match":false,"year":2018},{"alzhub_score":81,"alzhub_url":"https://alzhub.org/study/the-fda-approved-anti-amyloid-monoclonal-antibodies-for-the-treatment-38017568","doi":"10.1186/s40001-023-01512-w","journal":"European journal of medical research","n_participants":4471,"pmid":"38017568","source_url":"https://pubmed.ncbi.nlm.nih.gov/38017568/","study_design":"systematic review","title":"The FDA-approved anti-amyloid-\u03b2 monoclonal antibodies for the treatment of Alzheimer's disease: a systematic review and meta-analysis of randomized controlled trials","title_match":false,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/effects-of-pre-analytical-procedures-on-blood-biomarkers-for-34124336","doi":"10.1002/dad2.12168","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"34124336","source_url":"https://pubmed.ncbi.nlm.nih.gov/34124336/","study_design":null,"title":"Effects of pre-analytical procedures on blood biomarkers for Alzheimer's pathophysiology, glial activation, and neurodegeneration","title_match":false,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/identification-of-longitudinally-dynamic-biomarkers-in-alzheimer-s-24902845","doi":"10.1186/1750-1326-9-22","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"24902845","source_url":"https://pubmed.ncbi.nlm.nih.gov/24902845/","study_design":"longitudinal study","title":"Identification of longitudinally dynamic biomarkers in Alzheimer's disease cerebrospinal fluid by targeted proteomics","title_match":false,"year":2014},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/cerebral-and-extracerebral-cholesterol-metabolism-and-csf-markers-of-23291240","doi":"10.1016/j.bcp.2012.12.007","journal":"Biochemical pharmacology","n_participants":86,"pmid":"23291240","source_url":"https://pubmed.ncbi.nlm.nih.gov/23291240/","study_design":null,"title":"Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/diagnosis-of-alzheimer-s-disease-using-plasma-biomarkers-adjusted-to-39533113","doi":"10.1038/s43587-024-00731-y","journal":"Nature aging","n_participants":6896,"pmid":"39533113","source_url":"https://pubmed.ncbi.nlm.nih.gov/39533113/","study_design":"cohort study","title":"Diagnosis of Alzheimer's disease using plasma biomarkers adjusted to clinical probability","title_match":true,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/which-features-of-subjective-cognitive-decline-are-related-to-amyloid-31366409","doi":"10.1186/s13195-019-0515-y","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"31366409","source_url":"https://pubmed.ncbi.nlm.nih.gov/31366409/","study_design":null,"title":"Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study","title_match":false,"year":2019},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/a-novel-ultrasensitive-assay-for-plasma-p-tau217-performance-in-37975513","doi":"10.1002/alz.13525","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":308,"pmid":"37975513","source_url":"https://pubmed.ncbi.nlm.nih.gov/37975513/","study_design":null,"title":"A novel ultrasensitive assay for plasma p-tau217: Performance in individuals with subjective cognitive decline and early Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-p-tau181-to-a42-ratio-is-associated-with-brain-amyloid-burden-33792168","doi":"10.1002/alz.12332","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":43,"pmid":"33792168","source_url":"https://pubmed.ncbi.nlm.nih.gov/33792168/","study_design":null,"title":"Plasma P-tau181 to A\u03b242 ratio is associated with brain amyloid burden and hippocampal atrophy in an Asian cohort of Alzheimer's disease patients with concomitant cerebrovascular disease","title_match":true,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-biomarkers-for-early-and-differential-alzheimer-s-29562530","doi":"10.3233/jad-170680","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"29562530","source_url":"https://pubmed.ncbi.nlm.nih.gov/29562530/","study_design":null,"title":"Cerebrospinal Fluid Biomarkers for Early and Differential Alzheimer's Disease Diagnosis","title_match":false,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-markers-of-alzheimer-s-disease-pathology-and-26836182","doi":"10.3233/jad-150897","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"26836182","source_url":"https://pubmed.ncbi.nlm.nih.gov/26836182/","study_design":null,"title":"Cerebrospinal Fluid Markers of Alzheimer's Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer's Disease","title_match":false,"year":2016},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/plasma-phospho-tau181-in-presymptomatic-and-symptomatic-familial-32665603","doi":"10.1038/s41380-020-0838-x","journal":"Molecular psychiatry","n_participants":70,"pmid":"32665603","source_url":"https://pubmed.ncbi.nlm.nih.gov/32665603/","study_design":"longitudinal study","title":"Plasma phospho-tau181 in presymptomatic and symptomatic familial Alzheimer's disease: a longitudinal cohort study","title_match":false,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/csf-neurofilament-proteins-in-the-differential-diagnosis-of-dementia-17314187","doi":"10.1136/jnnp.2006.107326","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"17314187","source_url":"https://pubmed.ncbi.nlm.nih.gov/17314187/","study_design":null,"title":"CSF neurofilament proteins in the differential diagnosis of dementia","title_match":false,"year":2007},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/head-to-head-study-of-diagnostic-accuracy-of-plasma-and-cerebrospinal-38195896","doi":"10.1007/s00415-023-12148-5","journal":"Journal of neurology","n_participants":114,"pmid":"38195896","source_url":"https://pubmed.ncbi.nlm.nih.gov/38195896/","study_design":null,"title":"Head-to-head study of diagnostic accuracy of plasma and cerebrospinal fluid p-tau217 versus p-tau181 and p-tau231 in a memory clinic cohort","title_match":true,"year":2024},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/multi-analyte-proteomic-analysis-identifies-blood-based-39385222","doi":"10.1186/s13024-024-00753-5","journal":"Molecular neurodegeneration","n_participants":113,"pmid":"39385222","source_url":"https://pubmed.ncbi.nlm.nih.gov/39385222/","study_design":"cross-sectional","title":"Multi-analyte proteomic analysis identifies blood-based neuroinflammation, cerebrovascular and synaptic biomarkers in preclinical Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-alzheimer-s-disease-neuroimaging-initiative-2-biomarker-core-a-26194312","doi":"10.1016/j.jalz.2015.05.003","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"26194312","source_url":"https://pubmed.ncbi.nlm.nih.gov/26194312/","study_design":null,"title":"The Alzheimer's Disease Neuroimaging Initiative 2 Biomarker Core: A review of progress and plans","title_match":false,"year":2015},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/serum-amyloid-beta-levels-are-increased-in-patients-with-obstructive-26351108","doi":"10.1038/srep13917","journal":"Scientific reports","n_participants":null,"pmid":"26351108","source_url":"https://pubmed.ncbi.nlm.nih.gov/26351108/","study_design":null,"title":"Serum amyloid-beta levels are increased in patients with obstructive sleep apnea syndrome","title_match":false,"year":2015},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/differential-diagnostic-performance-of-a-panel-of-plasma-biomarkers-35603139","doi":"10.1002/dad2.12285","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":160,"pmid":"35603139","source_url":"https://pubmed.ncbi.nlm.nih.gov/35603139/","study_design":null,"title":"Differential diagnostic performance of a panel of plasma biomarkers for different types of dementia","title_match":true,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/comparison-of-two-plasma-p-tau217-assays-to-detect-and-monitor-38471397","doi":"10.1016/j.ebiom.2024.105046","journal":"EBioMedicine","n_participants":294,"pmid":"38471397","source_url":"https://pubmed.ncbi.nlm.nih.gov/38471397/","study_design":null,"title":"Comparison of two plasma p-tau217 assays to detect and monitor Alzheimer's pathology","title_match":true,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-p-tau181-and-p-tau217-in-discriminating-part-ad-and-other-key-37031430","doi":"10.1007/s00401-023-02570-4","journal":"Acta neuropathologica","n_participants":null,"pmid":"37031430","source_url":"https://pubmed.ncbi.nlm.nih.gov/37031430/","study_design":null,"title":"Plasma p-tau181 and p-tau217 in discriminating PART, AD and other key neuropathologies in older adults","title_match":true,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-p-tau231-p-tau181-pet-biomarkers-and-cognitive-change-in-older-35084051","doi":"10.1002/ana.26308","journal":"Annals of neurology","n_participants":129,"pmid":"35084051","source_url":"https://pubmed.ncbi.nlm.nih.gov/35084051/","study_design":null,"title":"Plasma p-tau231, p-tau181, PET Biomarkers, and Cognitive Change in Older Adults","title_match":true,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-amyloid-beta42-phosphorylated-tau-ratio-16870640","doi":"10.1093/gerona/61.7.755","journal":"The journals of gerontology. Series A, Biological sciences and medical sciences","n_participants":86,"pmid":"16870640","source_url":"https://pubmed.ncbi.nlm.nih.gov/16870640/","study_design":null,"title":"Cerebrospinal fluid amyloid beta42/phosphorylated tau ratio discriminates between Alzheimer's disease and vascular dementia","title_match":false,"year":2006},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/the-dynamics-of-plasma-biomarkers-across-the-alzheimer-s-continuum-36750875","doi":"10.1186/s13195-023-01174-0","journal":"Alzheimer's research & therapy","n_participants":206,"pmid":"36750875","source_url":"https://pubmed.ncbi.nlm.nih.gov/36750875/","study_design":null,"title":"The dynamics of plasma biomarkers across the Alzheimer's continuum","title_match":true,"year":2023},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/phosphorylated-tau-181-and-217-are-elevated-in-serum-and-muscle-of-40044663","doi":"10.1038/s41467-025-57144-7","journal":"Nature communications","n_participants":152,"pmid":"40044663","source_url":"https://pubmed.ncbi.nlm.nih.gov/40044663/","study_design":null,"title":"Phosphorylated tau 181 and 217 are elevated in serum and muscle of patients with amyotrophic lateral sclerosis","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/association-of-plasma-biomarkers-p-tau181-glial-fibrillary-acidic-35234335","doi":"10.1002/alz.12614","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":768,"pmid":"35234335","source_url":"https://pubmed.ncbi.nlm.nih.gov/35234335/","study_design":null,"title":"Association of plasma biomarkers, p-tau181, glial fibrillary acidic protein, and neurofilament light, with intermediate and long-term clinical Alzheimer's disease risk: Results from a prospective cohort followed over 17 years","title_match":true,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/application-of-the-atn-classification-scheme-in-a-population-without-33811742","doi":"10.1002/alz.12292","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"33811742","source_url":"https://pubmed.ncbi.nlm.nih.gov/33811742/","study_design":null,"title":"Application of the ATN classification scheme in a population without dementia: Findings from the EPAD cohort","title_match":false,"year":2021},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/effect-of-statins-on-alzheimer-s-disease-biomarkers-in-cerebrospinal-17183151","doi":"10.3233/jad-2006-10408","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"17183151","source_url":"https://pubmed.ncbi.nlm.nih.gov/17183151/","study_design":null,"title":"Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluid","title_match":false,"year":2006},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/the-alzheimer-s-association-global-biomarker-standardization-39907496","doi":"10.1002/alz.14508","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":40,"pmid":"39907496","source_url":"https://pubmed.ncbi.nlm.nih.gov/39907496/","study_design":"case-control study","title":"The Alzheimer's Association Global Biomarker Standardization Consortium (GBSC) plasma phospho-tau Round Robin study","title_match":false,"year":2025},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/longitudinal-changes-in-alzheimer-s-related-plasma-biomarkers-and-37216632","doi":"10.1002/alz.13157","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":199,"pmid":"37216632","source_url":"https://pubmed.ncbi.nlm.nih.gov/37216632/","study_design":"longitudinal study","title":"Longitudinal changes in Alzheimer's-related plasma biomarkers and brain amyloid","title_match":true,"year":2023},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/optimizing-cutpoints-for-clinical-interpretation-of-brain-amyloid-39030981","doi":"10.1002/alz.14140","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":427,"pmid":"39030981","source_url":"https://pubmed.ncbi.nlm.nih.gov/39030981/","study_design":null,"title":"Optimizing cutpoints for clinical interpretation of brain amyloid status using plasma p-tau217 immunoassays","title_match":true,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-and-phosphorylated-tau-181-as-biomarkers-33766131","doi":"10.1186/s13195-021-00805-8","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"33766131","source_url":"https://pubmed.ncbi.nlm.nih.gov/33766131/","study_design":null,"title":"Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer's disease pathology and clinical disease progression","title_match":false,"year":2021},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/the-cerebrospinal-fluid-a1-42-a1-40-ratio-improves-concordance-with-28869470","doi":"10.3233/jad-170327","journal":"Journal of Alzheimer's disease : JAD","n_participants":17,"pmid":"28869470","source_url":"https://pubmed.ncbi.nlm.nih.gov/28869470/","study_design":"longitudinal study","title":"The Cerebrospinal Fluid A\u03b21-42/A\u03b21-40 Ratio Improves Concordance with Amyloid-PET for Diagnosing Alzheimer's Disease in a Clinical Setting","title_match":false,"year":2017},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/discriminative-and-prognostic-potential-of-cerebrospinal-fluid-27239528","doi":"10.1016/j.dadm.2015.11.001","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":15,"pmid":"27239528","source_url":"https://pubmed.ncbi.nlm.nih.gov/27239528/","study_design":null,"title":"Discriminative and prognostic potential of cerebrospinal fluid phosphoTau/tau ratio and neurofilaments for frontotemporal dementia subtypes","title_match":false,"year":2015},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-predict-alzheimer-s-disease-before-clinical-onset-37875471","doi":"10.1038/s41467-023-42596-6","journal":"Nature communications","n_participants":126,"pmid":"37875471","source_url":"https://pubmed.ncbi.nlm.nih.gov/37875471/","study_design":null,"title":"Plasma biomarkers predict Alzheimer's disease before clinical onset in Chinese cohorts","title_match":true,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/detection-and-staging-of-alzheimer-s-disease-by-plasma-ptau217-on-a-39437657","doi":"10.1016/j.ebiom.2024.105405","journal":"EBioMedicine","n_participants":388,"pmid":"39437657","source_url":"https://pubmed.ncbi.nlm.nih.gov/39437657/","study_design":null,"title":"Detection and staging of Alzheimer's disease by plasma pTau217 on a high throughput immunoassay platform","title_match":true,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/blood-brain-barrier-opening-of-the-default-mode-network-in-alzheimer-36694943","doi":"10.1093/brain/awac459","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"36694943","source_url":"https://pubmed.ncbi.nlm.nih.gov/36694943/","study_design":null,"title":"Blood-brain barrier opening of the default mode network in Alzheimer's disease with magnetic resonance-guided focused ultrasound","title_match":false,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/test-retest-variability-of-plasma-biomarkers-in-alzheimer-s-disease-35699240","doi":"10.1002/alz.12706","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"35699240","source_url":"https://pubmed.ncbi.nlm.nih.gov/35699240/","study_design":null,"title":"Test-retest variability of plasma biomarkers in Alzheimer's disease and its effects on clinical prediction models","title_match":true,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/the-effects-of-normal-aging-and-apoe-genotype-on-the-levels-of-csf-17920160","doi":"10.1016/j.neurobiolaging.2007.08.019","journal":"Neurobiology of aging","n_participants":null,"pmid":"17920160","source_url":"https://pubmed.ncbi.nlm.nih.gov/17920160/","study_design":"longitudinal study","title":"The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease","title_match":false,"year":2009},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/dynamic-changes-of-csf-spdgfr-during-ageing-and-ad-progression-and-35033164","doi":"10.1186/s13024-021-00512-w","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"35033164","source_url":"https://pubmed.ncbi.nlm.nih.gov/35033164/","study_design":null,"title":"Dynamic changes of CSF sPDGFR\u03b2 during ageing and AD progression and associations with CSF ATN biomarkers","title_match":false,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-biomarker-profiles-and-the-correlation-with-cognitive-function-34225797","doi":"10.1186/s13195-021-00864-x","journal":"Alzheimer's research & therapy","n_participants":320,"pmid":"34225797","source_url":"https://pubmed.ncbi.nlm.nih.gov/34225797/","study_design":null,"title":"Plasma biomarker profiles and the correlation with cognitive function across the clinical spectrum of Alzheimer's disease","title_match":true,"year":2021},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-and-p-tau217-a1-42-are-effective-biomarkers-for-39887504","doi":"10.1002/alz.14536","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39887504","source_url":"https://pubmed.ncbi.nlm.nih.gov/39887504/","study_design":null,"title":"Plasma p-tau217 and p-tau217/A\u03b21-42 are effective biomarkers for identifying CSF- and PET imaging-diagnosed Alzheimer's disease: Insights for research and clinical practice","title_match":true,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/il-1-il-6-il-10-and-tnf-single-nucleotide-polymorphisms-in-human-32390629","doi":"10.3233/jad-200056","journal":"Journal of Alzheimer's disease : JAD","n_participants":115,"pmid":"32390629","source_url":"https://pubmed.ncbi.nlm.nih.gov/32390629/","study_design":null,"title":"IL-1\u03b2, IL-6, IL-10, and TNF\u03b1 Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer's Disease Pathology","title_match":false,"year":2020},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/plasma-p-tau-immunoassays-in-clinical-research-for-alzheimer-s-disease-39625101","doi":"10.1002/alz.14397","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39625101","source_url":"https://pubmed.ncbi.nlm.nih.gov/39625101/","study_design":null,"title":"Plasma p-tau immunoassays in clinical research for Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/diagnostic-value-of-serum-versus-plasma-phospho-tau-for-alzheimer-s-35545792","doi":"10.1186/s13195-022-01011-w","journal":"Alzheimer's research & therapy","n_participants":115,"pmid":"35545792","source_url":"https://pubmed.ncbi.nlm.nih.gov/35545792/","study_design":null,"title":"Diagnostic value of serum versus plasma phospho-tau for Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/nanomedicine-based-technologies-and-novel-biomarkers-for-the-33926475","doi":"10.1186/s12951-021-00864-x","journal":"Journal of nanobiotechnology","n_participants":null,"pmid":"33926475","source_url":"https://pubmed.ncbi.nlm.nih.gov/33926475/","study_design":null,"title":"Nanomedicine-based technologies and novel biomarkers for the diagnosis and treatment of Alzheimer's disease: from current to future challenges","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/insulin-resistance-is-associated-with-higher-cerebrospinal-fluid-tau-25812851","doi":"10.3233/jad-150072","journal":"Journal of Alzheimer's disease : JAD","n_participants":113,"pmid":"25812851","source_url":"https://pubmed.ncbi.nlm.nih.gov/25812851/","study_design":null,"title":"Insulin Resistance is Associated with Higher Cerebrospinal Fluid Tau Levels in Asymptomatic APOE\u025b4 Carriers","title_match":false,"year":2015},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/phosphorylated-tau181-in-plasma-as-a-potential-biomarker-for-34262030","doi":"10.1038/s41467-021-24319-x","journal":"Nature communications","n_participants":366,"pmid":"34262030","source_url":"https://pubmed.ncbi.nlm.nih.gov/34262030/","study_design":null,"title":"Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome","title_match":false,"year":2021},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-181-predicts-amyloid-status-and-conversion-37012068","doi":"10.1136/jnnp-2022-330540","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"37012068","source_url":"https://pubmed.ncbi.nlm.nih.gov/37012068/","study_design":null,"title":"Plasma phosphorylated tau 181 predicts amyloid status and conversion to dementia stage dependent on renal function","title_match":false,"year":2023},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau181-as-a-predictive-biomarker-for-alzheimer-34775468","doi":"10.1038/s41398-021-01709-9","journal":"Translational psychiatry","n_participants":1189,"pmid":"34775468","source_url":"https://pubmed.ncbi.nlm.nih.gov/34775468/","study_design":"cross-sectional","title":"Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer's amyloid, tau and FDG PET status","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/p-tau217-as-a-reliable-blood-based-marker-of-alzheimer-s-disease-39200300","doi":"10.3390/biomedicines12081836","journal":"Biomedicines","n_participants":null,"pmid":"39200300","source_url":"https://pubmed.ncbi.nlm.nih.gov/39200300/","study_design":"narrative review","title":"P-tau217 as a Reliable Blood-Based Marker of Alzheimer's Disease","title_match":true,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/trajectories-of-csf-and-plasma-biomarkers-across-alzheimer-s-disease-37977432","doi":"10.1016/j.nbd.2023.106356","journal":"Neurobiology of disease","n_participants":173,"pmid":"37977432","source_url":"https://pubmed.ncbi.nlm.nih.gov/37977432/","study_design":null,"title":"Trajectories of CSF and plasma biomarkers across Alzheimer's disease continuum: disease staging by NF-L, p-tau181, and GFAP","title_match":true,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/cellular-localization-of-p-tau217-in-brain-and-its-association-with-p-34991721","doi":"10.1186/s40478-021-01307-2","journal":"Acta neuropathologica communications","n_participants":null,"pmid":"34991721","source_url":"https://pubmed.ncbi.nlm.nih.gov/34991721/","study_design":null,"title":"Cellular localization of p-tau217 in brain and its association with p-tau217 plasma levels","title_match":true,"year":2022},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/combining-plasma-a-and-p-tau217-improves-detection-of-brain-amyloid-38778353","doi":"10.1186/s13195-024-01469-w","journal":"Alzheimer's research & therapy","n_participants":474,"pmid":"38778353","source_url":"https://pubmed.ncbi.nlm.nih.gov/38778353/","study_design":"cross-sectional","title":"Combining plasma A\u03b2 and p-tau217 improves detection of brain amyloid in non-demented elderly","title_match":true,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/csf-p-tau181-tau-ratio-as-biomarker-for-tdp-pathology-in-25352065","doi":"10.3109/21678421.2014.971812","journal":"Amyotrophic lateral sclerosis & frontotemporal degeneration","n_participants":39,"pmid":"25352065","source_url":"https://pubmed.ncbi.nlm.nih.gov/25352065/","study_design":null,"title":"Csf p-tau181/tau ratio as biomarker for TDP pathology in frontotemporal dementia","title_match":true,"year":2015},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/the-bio-hermes-study-biomarker-database-developed-to-investigate-38415908","doi":"10.1002/alz.13722","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":417,"pmid":"38415908","source_url":"https://pubmed.ncbi.nlm.nih.gov/38415908/","study_design":null,"title":"The Bio-Hermes Study: Biomarker database developed to investigate blood-based and digital biomarkers in community-based, diverse populations clinically screened for Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/amyloid-beta-misfolding-and-gfap-predict-risk-of-clinical-alzheimer-s-35852967","doi":"10.1002/alz.12745","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":68,"pmid":"35852967","source_url":"https://pubmed.ncbi.nlm.nih.gov/35852967/","study_design":null,"title":"Amyloid-beta misfolding and GFAP predict risk of clinical Alzheimer's disease diagnosis within 17 years","title_match":false,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/associations-of-longitudinal-plasma-p-tau181-and-nfl-with-tau-pet-a-34187867","doi":"10.1136/jnnp-2020-325537","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"34187867","source_url":"https://pubmed.ncbi.nlm.nih.gov/34187867/","study_design":"longitudinal study","title":"Associations of longitudinal plasma p-tau181 and NfL with tau-PET, A\u03b2-PET and cognition","title_match":true,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-for-alzheimer-s-disease-towards-clinical-34838239","doi":"10.1016/s1474-4422(21)00361-6","journal":"The Lancet. Neurology","n_participants":null,"pmid":"34838239","source_url":"https://pubmed.ncbi.nlm.nih.gov/34838239/","study_design":null,"title":"Blood-based biomarkers for Alzheimer's disease: towards clinical implementation","title_match":true,"year":2022},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/increased-neurofilament-light-chain-blood-levels-in-neurodegenerative-24073237","doi":"10.1371/journal.pone.0075091","journal":"PloS one","n_participants":20,"pmid":"24073237","source_url":"https://pubmed.ncbi.nlm.nih.gov/24073237/","study_design":"longitudinal study","title":"Increased neurofilament light chain blood levels in neurodegenerative neurological diseases","title_match":false,"year":2013},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/plasma-concentration-of-the-neurofilament-light-protein-nfl-is-a-26870824","doi":"10.1016/j.ebiom.2015.11.036","journal":"EBioMedicine","n_participants":null,"pmid":"26870824","source_url":"https://pubmed.ncbi.nlm.nih.gov/26870824/","study_design":"cross-sectional","title":"Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection: A Cross-Sectional Study","title_match":false,"year":2016},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/plasma-glial-fibrillary-acidic-protein-is-elevated-in-cognitively-33431793","doi":"10.1038/s41398-020-01137-1","journal":"Translational psychiatry","n_participants":63,"pmid":"33431793","source_url":"https://pubmed.ncbi.nlm.nih.gov/33431793/","study_design":"cross-sectional","title":"Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-and-plasma-biomarker-trajectories-with-increasing-31709776","doi":"10.15252/emmm.201911170","journal":"EMBO molecular medicine","n_participants":377,"pmid":"31709776","source_url":"https://pubmed.ncbi.nlm.nih.gov/31709776/","study_design":"cross-sectional","title":"Cerebrospinal fluid and plasma biomarker trajectories with increasing amyloid deposition in Alzheimer's disease","title_match":true,"year":2019},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-for-alzheimer-s-disease-34859598","doi":"10.15252/emmm.202114408","journal":"EMBO molecular medicine","n_participants":null,"pmid":"34859598","source_url":"https://pubmed.ncbi.nlm.nih.gov/34859598/","study_design":null,"title":"Blood-based biomarkers for Alzheimer's disease","title_match":true,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/neurofilament-proteins-as-biomarkers-to-monitor-neurological-diseases-34646114","doi":"10.3389/fnins.2021.689938","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"34646114","source_url":"https://pubmed.ncbi.nlm.nih.gov/34646114/","study_design":null,"title":"Neurofilament Proteins as Biomarkers to Monitor Neurological Diseases and the Efficacy of Therapies","title_match":false,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-and-csf-neurofilament-light-relation-to-longitudinal-31182505","doi":"10.1212/wnl.0000000000007767","journal":"Neurology","n_participants":null,"pmid":"31182505","source_url":"https://pubmed.ncbi.nlm.nih.gov/31182505/","study_design":"cross-sectional","title":"Plasma and CSF neurofilament light: Relation to longitudinal neuroimaging and cognitive measures","title_match":false,"year":2019},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/neurofilament-light-chain-in-serum-for-the-diagnosis-of-amyotrophic-30309882","doi":"10.1136/jnnp-2018-318704","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":124,"pmid":"30309882","source_url":"https://pubmed.ncbi.nlm.nih.gov/30309882/","study_design":"longitudinal study","title":"Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis","title_match":false,"year":2019},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/associations-of-amyloid-and-neurodegeneration-plasma-biomarkers-with-34569696","doi":"10.1002/alz.12466","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"34569696","source_url":"https://pubmed.ncbi.nlm.nih.gov/34569696/","study_design":null,"title":"Associations of amyloid and neurodegeneration plasma biomarkers with comorbidities","title_match":true,"year":2022},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/neurofilament-light-chain-a-biomarker-for-genetic-frontotemporal-27606344","doi":"10.1002/acn3.325","journal":"Annals of clinical and translational neurology","n_participants":174,"pmid":"27606344","source_url":"https://pubmed.ncbi.nlm.nih.gov/27606344/","study_design":"case-control study","title":"Neurofilament light chain: a biomarker for genetic frontotemporal dementia","title_match":false,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-of-astrocytic-and-neuronal-dysfunction-in-early-and-31879236","doi":"10.1016/j.jalz.2019.09.004","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"31879236","source_url":"https://pubmed.ncbi.nlm.nih.gov/31879236/","study_design":null,"title":"Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's disease","title_match":true,"year":2020},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/combination-of-plasma-amyloid-beta-1-42-1-40-and-glial-fibrillary-32988409","doi":"10.1186/s13195-020-00682-7","journal":"Alzheimer's research & therapy","n_participants":176,"pmid":"32988409","source_url":"https://pubmed.ncbi.nlm.nih.gov/32988409/","study_design":null,"title":"Combination of plasma amyloid beta (1-42/1-40) and glial fibrillary acidic protein strongly associates with cerebral amyloid pathology","title_match":true,"year":2020},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/a-review-of-fluid-biomarkers-for-alzheimer-s-disease-moving-from-csf-28733960","doi":"10.1007/s40120-017-0073-9","journal":"Neurology and therapy","n_participants":null,"pmid":"28733960","source_url":"https://pubmed.ncbi.nlm.nih.gov/28733960/","study_design":"longitudinal study","title":"A Review of Fluid Biomarkers for Alzheimer's Disease: Moving from CSF to Blood","title_match":false,"year":2017},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/brain-derived-tau-a-novel-blood-based-biomarker-for-alzheimer-s-36572122","doi":"10.1093/brain/awac407","journal":"Brain : a journal of neurology","n_participants":609,"pmid":"36572122","source_url":"https://pubmed.ncbi.nlm.nih.gov/36572122/","study_design":null,"title":"Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration","title_match":true,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/characterization-of-pre-analytical-sample-handling-effects-on-a-panel-34845818","doi":"10.1002/alz.12510","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"34845818","source_url":"https://pubmed.ncbi.nlm.nih.gov/34845818/","study_design":null,"title":"Characterization of pre-analytical sample handling effects on a panel of Alzheimer's disease-related blood-based biomarkers: Results from the Standardization of Alzheimer's Blood Biomarkers (SABB) working group","title_match":true,"year":2022},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/blood-nfl-a-biomarker-for-disease-severity-and-progression-in-31420461","doi":"10.1212/wnl.0000000000008088","journal":"Neurology","n_participants":178,"pmid":"31420461","source_url":"https://pubmed.ncbi.nlm.nih.gov/31420461/","study_design":null,"title":"Blood NfL: A biomarker for disease severity and progression in Parkinson disease","title_match":false,"year":2019},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/renal-function-is-associated-with-blood-neurofilament-light-chain-33230211","doi":"10.1038/s41598-020-76990-7","journal":"Scientific reports","n_participants":43,"pmid":"33230211","source_url":"https://pubmed.ncbi.nlm.nih.gov/33230211/","study_design":null,"title":"Renal function is associated with blood neurofilament light chain level in older adults","title_match":false,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/moving-fluid-biomarkers-for-alzheimer-s-disease-from-research-tools-33608044","doi":"10.1186/s13024-021-00430-x","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"33608044","source_url":"https://pubmed.ncbi.nlm.nih.gov/33608044/","study_design":null,"title":"Moving fluid biomarkers for Alzheimer's disease from research tools to routine clinical diagnostics","title_match":false,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/neurofilament-light-chain-as-a-biomarker-for-cognitive-decline-in-34480363","doi":"10.1002/mds.28779","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"34480363","source_url":"https://pubmed.ncbi.nlm.nih.gov/34480363/","study_design":"cross-sectional","title":"Neurofilament Light Chain as a Biomarker for Cognitive Decline in Parkinson Disease","title_match":false,"year":2021},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/a-blood-based-diagnostic-test-incorporating-plasma-a42-40-ratio-apoe-33933117","doi":"10.1186/s13024-021-00451-6","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"33933117","source_url":"https://pubmed.ncbi.nlm.nih.gov/33933117/","study_design":null,"title":"A blood-based diagnostic test incorporating plasma A\u03b242/40 ratio, ApoE proteotype, and age accurately identifies brain amyloid status: findings from a multi cohort validity analysis","title_match":true,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-42-40-ratios-as-biomarkers-for-amyloid-cerebral-28948206","doi":"10.1016/j.dadm.2017.07.004","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"28948206","source_url":"https://pubmed.ncbi.nlm.nih.gov/28948206/","study_design":"cross-sectional","title":"Plasma amyloid \u03b2 42/40 ratios as biomarkers for amyloid \u03b2 cerebral deposition in cognitively normal individuals","title_match":true,"year":2017},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/clinical-validation-of-the-lumipulse-g-cerebrospinal-fluid-assays-for-31759396","doi":"10.1186/s13195-019-0550-8","journal":"Alzheimer's research & therapy","n_participants":80,"pmid":"31759396","source_url":"https://pubmed.ncbi.nlm.nih.gov/31759396/","study_design":null,"title":"Clinical validation of the Lumipulse G cerebrospinal fluid assays for routine diagnosis of Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/plasma-markers-predict-changes-in-amyloid-tau-atrophy-and-cognition-34077494","doi":"10.1093/brain/awab163","journal":"Brain : a journal of neurology","n_participants":123,"pmid":"34077494","source_url":"https://pubmed.ncbi.nlm.nih.gov/34077494/","study_design":"longitudinal study","title":"Plasma markers predict changes in amyloid, tau, atrophy and cognition in non-demented subjects","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-past-and-the-future-of-alzheimer-s-disease-fluid-biomarkers-29562534","doi":"10.3233/jad-170773","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"29562534","source_url":"https://pubmed.ncbi.nlm.nih.gov/29562534/","study_design":null,"title":"The Past and the Future of Alzheimer's Disease Fluid Biomarkers","title_match":false,"year":2018},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-precivityadtm-test-accurate-and-reliable-lc-ms-ms-assays-for-34015303","doi":"10.1016/j.cca.2021.05.011","journal":"Clinica chimica acta; international journal of clinical chemistry","n_participants":null,"pmid":"34015303","source_url":"https://pubmed.ncbi.nlm.nih.gov/34015303/","study_design":null,"title":"The PrecivityAD\u2122 test: Accurate and reliable LC-MS/MS assays for quantifying plasma amyloid beta 40 and 42 and apolipoprotein E proteotype for the assessment of brain amyloidosis","title_match":true,"year":2021},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/genome-wide-haplotype-association-study-identifies-the-frmd4a-gene-as-22430674","doi":"10.1038/mp.2012.14","journal":"Molecular psychiatry","n_participants":2025,"pmid":"22430674","source_url":"https://pubmed.ncbi.nlm.nih.gov/22430674/","study_design":"case-control study","title":"Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-a-but-not-tau-is-related-to-brain-pib-retention-in-early-25054847","doi":"10.1021/cn500101j","journal":"ACS chemical neuroscience","n_participants":25,"pmid":"25054847","source_url":"https://pubmed.ncbi.nlm.nih.gov/25054847/","study_design":null,"title":"Plasma A\u03b2 but not tau is related to brain PiB retention in early Alzheimer's disease","title_match":true,"year":2014},{"alzhub_score":81,"alzhub_url":"https://alzhub.org/study/assessment-of-plasma-amyloid-42-40-and-cognitive-decline-among-33331917","doi":"10.1001/jamanetworkopen.2020.28634","journal":"JAMA network open","n_participants":448,"pmid":"33331917","source_url":"https://pubmed.ncbi.nlm.nih.gov/33331917/","study_design":"cohort study","title":"Assessment of Plasma Amyloid-\u03b242/40 and Cognitive Decline Among Community-Dwelling Older Adults","title_match":true,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/current-advances-in-plasma-and-cerebrospinal-fluid-biomarkers-in-33470669","doi":"10.1097/wco.0000000000000904","journal":"Current opinion in neurology","n_participants":null,"pmid":"33470669","source_url":"https://pubmed.ncbi.nlm.nih.gov/33470669/","study_design":null,"title":"Current advances in plasma and cerebrospinal fluid biomarkers in Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-beta-levels-are-associated-with-cerebral-amyloid-and-31384662","doi":"10.1016/j.dadm.2019.05.007","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"31384662","source_url":"https://pubmed.ncbi.nlm.nih.gov/31384662/","study_design":null,"title":"Plasma amyloid beta levels are associated with cerebral amyloid and tau deposition","title_match":true,"year":2019},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-abeta42-and-abeta40-as-markers-of-cognitive-change-in-follow-20478847","doi":"10.1136/jnnp.2010.205757","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":269,"pmid":"20478847","source_url":"https://pubmed.ncbi.nlm.nih.gov/20478847/","study_design":null,"title":"Plasma Abeta42 and Abeta40 as markers of cognitive change in follow-up: a prospective, longitudinal, population-based cohort study","title_match":true,"year":2010},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/acute-sleep-loss-decreases-csf-to-blood-clearance-of-alzheimer-s-36695437","doi":"10.1002/alz.12930","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"36695437","source_url":"https://pubmed.ncbi.nlm.nih.gov/36695437/","study_design":null,"title":"Acute sleep loss decreases CSF-to-blood clearance of Alzheimer's disease biomarkers","title_match":false,"year":2023},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-for-the-diagnosis-of-amnestic-mild-cognitive-34245759","doi":"10.1016/j.neubiorev.2021.07.007","journal":"Neuroscience and biobehavioral reviews","n_participants":null,"pmid":"34245759","source_url":"https://pubmed.ncbi.nlm.nih.gov/34245759/","study_design":"meta-analysis","title":"Blood biomarkers for the diagnosis of amnestic mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis","title_match":false,"year":2021},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/the-effect-of-cognitive-motor-dual-task-training-on-cognitive-26018225","doi":"10.1186/s12877-015-0058-4","journal":"BMC geriatrics","n_participants":27,"pmid":"26018225","source_url":"https://pubmed.ncbi.nlm.nih.gov/26018225/","study_design":null,"title":"The effect of cognitive-motor dual-task training on cognitive function and plasma amyloid \u03b2 peptide 42/40 ratio in healthy elderly persons: a randomized controlled trial","title_match":true,"year":2015},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/performance-of-a-fully-automated-lumipulse-plasma-phospho-tau181-36371232","doi":"10.1186/s13195-022-01116-2","journal":"Alzheimer's research & therapy","n_participants":463,"pmid":"36371232","source_url":"https://pubmed.ncbi.nlm.nih.gov/36371232/","study_design":"longitudinal study","title":"Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/comparative-analytical-performance-of-multiple-plasma-a42-and-a40-35820077","doi":"10.1002/alz.12697","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"35820077","source_url":"https://pubmed.ncbi.nlm.nih.gov/35820077/","study_design":null,"title":"Comparative analytical performance of multiple plasma A\u03b242 and A\u03b240 assays and their ability to predict positron emission tomography amyloid positivity","title_match":true,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/biological-variation-estimates-of-alzheimer-s-disease-plasma-37985230","doi":"10.1002/alz.13518","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":20,"pmid":"37985230","source_url":"https://pubmed.ncbi.nlm.nih.gov/37985230/","study_design":null,"title":"Biological variation estimates of Alzheimer's disease plasma biomarkers in healthy individuals","title_match":true,"year":2024},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/diagnostic-biomarkers-of-amyloid-and-tau-pathology-in-alzheimer-s-37357283","doi":"10.14283/jpad.2023.43","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"37357283","source_url":"https://pubmed.ncbi.nlm.nih.gov/37357283/","study_design":null,"title":"Diagnostic Biomarkers of Amyloid and Tau Pathology in Alzheimer's Disease: An Overview of Tests for Clinical Practice in the United States and Europe","title_match":false,"year":2023},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/chemically-treated-plasma-a-is-a-potential-blood-based-biomarker-for-28330509","doi":"10.1186/s13195-017-0248-8","journal":"Alzheimer's research & therapy","n_participants":353,"pmid":"28330509","source_url":"https://pubmed.ncbi.nlm.nih.gov/28330509/","study_design":"cross-sectional","title":"Chemically treated plasma A\u03b2 is a potential blood-based biomarker for screening cerebral amyloid deposition","title_match":true,"year":2017},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-a40-improves-the-interpretation-of-a42-26640457","doi":"10.3389/fneur.2015.00247","journal":"Frontiers in neurology","n_participants":null,"pmid":"26640457","source_url":"https://pubmed.ncbi.nlm.nih.gov/26640457/","study_design":null,"title":"Cerebrospinal Fluid A\u03b240 Improves the Interpretation of A\u03b242 Concentration for Diagnosing Alzheimer's Disease","title_match":false,"year":2015},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-in-alzheimer-s-disease-moving-towards-a-new-38253262","doi":"10.1515/cclm-2023-1434","journal":"Clinical chemistry and laboratory medicine","n_participants":null,"pmid":"38253262","source_url":"https://pubmed.ncbi.nlm.nih.gov/38253262/","study_design":null,"title":"Blood-based biomarkers in Alzheimer's disease - moving towards a new era of diagnostics","title_match":true,"year":2024},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/elevation-in-plasma-abeta42-in-geriatric-depression-a-pilot-study-16583267","doi":"10.1007/s11064-005-9029-z","journal":"Neurochemical research","n_participants":null,"pmid":"16583267","source_url":"https://pubmed.ncbi.nlm.nih.gov/16583267/","study_design":null,"title":"Elevation in plasma Abeta42 in geriatric depression: a pilot study","title_match":true,"year":2006},{"alzhub_score":84,"alzhub_url":"https://alzhub.org/study/blarcamesine-for-the-treatment-of-early-alzheimer-s-disease-results-39800452","doi":"10.1016/j.tjpad.2024.100016","journal":"The journal of prevention of Alzheimer's disease","n_participants":338,"pmid":"39800452","source_url":"https://pubmed.ncbi.nlm.nih.gov/39800452/","study_design":"open-label trial","title":"Blarcamesine for the treatment of Early Alzheimer's Disease: Results from the ANAVEX2-73-AD-004 Phase IIB/III trial","title_match":false,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/the-cerebrospinal-fluid-biomarker-ratio-a42-40-identifies-amyloid-35473631","doi":"10.1186/s13195-022-01003-w","journal":"Alzheimer's research & therapy","n_participants":44,"pmid":"35473631","source_url":"https://pubmed.ncbi.nlm.nih.gov/35473631/","study_design":null,"title":"The cerebrospinal fluid biomarker ratio A\u03b242/40 identifies amyloid positron emission tomography positivity better than A\u03b242 alone in a heterogeneous memory clinic cohort","title_match":false,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-a42-40-ratio-alone-or-combined-with-fdg-pet-can-accurately-31787105","doi":"10.1186/s13195-019-0549-1","journal":"Alzheimer's research & therapy","n_participants":39,"pmid":"31787105","source_url":"https://pubmed.ncbi.nlm.nih.gov/31787105/","study_design":null,"title":"Plasma A\u03b242/40 ratio alone or combined with FDG-PET can accurately predict amyloid-PET positivity: a cross-sectional analysis from the AB255 Study","title_match":true,"year":2019},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/combining-plasma-phospho-tau-and-accessible-measures-to-evaluate-35351181","doi":"10.1186/s13195-022-00990-0","journal":"Alzheimer's research & therapy","n_participants":110,"pmid":"35351181","source_url":"https://pubmed.ncbi.nlm.nih.gov/35351181/","study_design":null,"title":"Combining plasma phospho-tau and accessible measures to evaluate progression to Alzheimer's dementia in mild cognitive impairment patients","title_match":false,"year":2022},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/the-impact-of-kidney-function-on-alzheimer-s-disease-blood-biomarkers-39972340","doi":"10.1186/s13195-025-01692-z","journal":"Alzheimer's research & therapy","n_participants":124,"pmid":"39972340","source_url":"https://pubmed.ncbi.nlm.nih.gov/39972340/","study_design":null,"title":"The impact of kidney function on Alzheimer's disease blood biomarkers: implications for predicting amyloid-\u03b2 positivity","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/sleep-deprivation-induced-plasma-amyloid-transport-disturbance-in-28304302","doi":"10.3233/jad-161213","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"28304302","source_url":"https://pubmed.ncbi.nlm.nih.gov/28304302/","study_design":null,"title":"Sleep Deprivation Induced Plasma Amyloid-\u03b2 Transport Disturbance in Healthy Young Adults","title_match":true,"year":2017},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/comparison-of-plasma-and-csf-biomarkers-in-predicting-cognitive-36183195","doi":"10.1002/acn3.51670","journal":"Annals of clinical and translational neurology","n_participants":371,"pmid":"36183195","source_url":"https://pubmed.ncbi.nlm.nih.gov/36183195/","study_design":null,"title":"Comparison of plasma and CSF biomarkers in predicting cognitive decline","title_match":false,"year":2022},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/organ-aging-signatures-in-the-plasma-proteome-track-health-and-disease-38057571","doi":"10.1038/s41586-023-06802-1","journal":"Nature","n_participants":5676,"pmid":"38057571","source_url":"https://pubmed.ncbi.nlm.nih.gov/38057571/","study_design":null,"title":"Organ aging signatures in the plasma proteome track health and disease","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/guidelines-for-the-standardization-of-preanalytic-variables-for-blood-25282381","doi":"10.1016/j.jalz.2014.08.099","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"25282381","source_url":"https://pubmed.ncbi.nlm.nih.gov/25282381/","study_design":"cohort study","title":"Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research","title_match":true,"year":2015},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-future-of-blood-based-biomarkers-for-alzheimer-s-disease-23850333","doi":"10.1016/j.jalz.2013.01.013","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"23850333","source_url":"https://pubmed.ncbi.nlm.nih.gov/23850333/","study_design":null,"title":"The future of blood-based biomarkers for Alzheimer's disease","title_match":true,"year":2014},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/healthy-centenarians-do-not-exist-but-autonomous-centenarians-do-a-11527481","doi":"10.1046/j.1532-5415.2001.49180.x","journal":"Journal of the American Geriatrics Society","n_participants":276,"pmid":"11527481","source_url":"https://pubmed.ncbi.nlm.nih.gov/11527481/","study_design":null,"title":"Healthy centenarians do not exist, but autonomous centenarians do: a population-based study of morbidity among Danish centenarians","title_match":false,"year":2001},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/therapeutic-inhibition-of-the-complement-system-in-diseases-of-the-30886620","doi":"10.3389/fimmu.2019.00362","journal":"Frontiers in immunology","n_participants":null,"pmid":"30886620","source_url":"https://pubmed.ncbi.nlm.nih.gov/30886620/","study_design":null,"title":"Therapeutic Inhibition of the Complement System in Diseases of the Central Nervous System","title_match":false,"year":2019},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/serum-sphingomyelins-and-ceramides-are-early-predictors-of-memory-18455839","doi":"10.1016/j.neurobiolaging.2008.03.011","journal":"Neurobiology of aging","n_participants":null,"pmid":"18455839","source_url":"https://pubmed.ncbi.nlm.nih.gov/18455839/","study_design":"cross-sectional","title":"Serum sphingomyelins and ceramides are early predictors of memory impairment","title_match":false,"year":2010},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/developing-novel-blood-based-biomarkers-for-alzheimer-s-disease-24365657","doi":"10.1016/j.jalz.2013.10.007","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"24365657","source_url":"https://pubmed.ncbi.nlm.nih.gov/24365657/","study_design":null,"title":"Developing novel blood-based biomarkers for Alzheimer's disease","title_match":true,"year":2014},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/c-terminal-neurogranin-is-increased-in-cerebrospinal-fluid-but-26092348","doi":"10.1016/j.jalz.2015.05.012","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":29,"pmid":"26092348","source_url":"https://pubmed.ncbi.nlm.nih.gov/26092348/","study_design":null,"title":"C-terminal neurogranin is increased in cerebrospinal fluid but unchanged in plasma in Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/alternations-of-metabolic-profile-and-kynurenine-metabolism-in-the-29294246","doi":"10.1007/s12035-017-0845-3","journal":"Molecular neurobiology","n_participants":null,"pmid":"29294246","source_url":"https://pubmed.ncbi.nlm.nih.gov/29294246/","study_design":null,"title":"Alternations of Metabolic Profile and Kynurenine Metabolism in the Plasma of Parkinson's Disease","title_match":false,"year":2018},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/oligomeric-forms-of-amyloid-protein-in-plasma-as-a-potential-blood-29246249","doi":"10.1186/s13195-017-0324-0","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"29246249","source_url":"https://pubmed.ncbi.nlm.nih.gov/29246249/","study_design":null,"title":"Oligomeric forms of amyloid-\u03b2 protein in plasma as a potential blood-based biomarker for Alzheimer's disease","title_match":true,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/hyperhomocysteinemia-as-a-risk-factor-and-potential-nutraceutical-31069230","doi":"10.3389/fnut.2019.00049","journal":"Frontiers in nutrition","n_participants":null,"pmid":"31069230","source_url":"https://pubmed.ncbi.nlm.nih.gov/31069230/","study_design":null,"title":"Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies","title_match":false,"year":2019},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/a-blood-based-screening-tool-for-alzheimer-s-disease-that-spans-serum-22163278","doi":"10.1371/journal.pone.0028092","journal":"PloS one","n_participants":null,"pmid":"22163278","source_url":"https://pubmed.ncbi.nlm.nih.gov/22163278/","study_design":null,"title":"A blood-based screening tool for Alzheimer's disease that spans serum and plasma: findings from TARC and ADNI","title_match":false,"year":2011},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/long-non-coding-rna-bace1-as-may-serve-as-an-alzheimer-s-disease-31264051","doi":"10.1007/s12031-019-01364-2","journal":"Journal of molecular neuroscience : MN","n_participants":45,"pmid":"31264051","source_url":"https://pubmed.ncbi.nlm.nih.gov/31264051/","study_design":null,"title":"Long Non-coding RNA BACE1-AS May Serve as an Alzheimer's Disease Blood-Based Biomarker","title_match":true,"year":2019},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/novel-plasma-biomarker-surrogating-cerebral-amyloid-deposition-25391320","doi":"10.2183/pjab.90.353","journal":"Proceedings of the Japan Academy. Series B, Physical and biological sciences","n_participants":null,"pmid":"25391320","source_url":"https://pubmed.ncbi.nlm.nih.gov/25391320/","study_design":null,"title":"Novel plasma biomarker surrogating cerebral amyloid deposition","title_match":true,"year":2014},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-beta-measurements-a-desired-but-elusive-alzheimer-s-23470128","doi":"10.1186/alzrt162","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"23470128","source_url":"https://pubmed.ncbi.nlm.nih.gov/23470128/","study_design":"cross-sectional","title":"Plasma amyloid beta measurements - a desired but elusive Alzheimer's disease biomarker","title_match":true,"year":2013},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/association-of-plasma-glial-fibrillary-acidic-protein-gfap-with-35252538","doi":"10.1002/dad2.12291","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":200,"pmid":"35252538","source_url":"https://pubmed.ncbi.nlm.nih.gov/35252538/","study_design":"cross-sectional","title":"Association of plasma glial fibrillary acidic protein (GFAP) with neuroimaging of Alzheimer's disease and vascular pathology","title_match":false,"year":2022},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/identification-of-a-new-plasma-biomarker-of-alzheimer-s-disease-using-22203775","doi":"10.1194/jlr.m022376","journal":"Journal of lipid research","n_participants":null,"pmid":"22203775","source_url":"https://pubmed.ncbi.nlm.nih.gov/22203775/","study_design":null,"title":"Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology","title_match":true,"year":2012},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/neuronally-derived-extracellular-vesicle-synuclein-as-a-serum-38048087","doi":"10.1001/jamaneurol.2023.4398","journal":"JAMA neurology","n_participants":170,"pmid":"38048087","source_url":"https://pubmed.ncbi.nlm.nih.gov/38048087/","study_design":"cross-sectional","title":"Neuronally Derived Extracellular Vesicle \u03b1-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-behavioural-and-neuropathologic-sexual-dimorphism-and-absence-of-32093751","doi":"10.1186/s12974-020-01749-w","journal":"Journal of neuroinflammation","n_participants":null,"pmid":"32093751","source_url":"https://pubmed.ncbi.nlm.nih.gov/32093751/","study_design":null,"title":"The behavioural and neuropathologic sexual dimorphism and absence of MIP-3\u03b1 in tau P301S mouse model of Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-for-alzheimer-s-disease-diagnosis-and-35456047","doi":"10.3390/cells11081367","journal":"Cells","n_participants":null,"pmid":"35456047","source_url":"https://pubmed.ncbi.nlm.nih.gov/35456047/","study_design":"narrative review","title":"Blood-Based Biomarkers for Alzheimer's Disease Diagnosis and Progression: An Overview","title_match":true,"year":2022},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/biochemical-markers-related-to-alzheimer-s-dementia-in-serum-and-12009495","doi":"10.1016/s0197-4580(01)00328-1","journal":"Neurobiology of aging","n_participants":null,"pmid":"12009495","source_url":"https://pubmed.ncbi.nlm.nih.gov/12009495/","study_design":null,"title":"Biochemical markers related to Alzheimer's dementia in serum and cerebrospinal fluid","title_match":false,"year":2002},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/neurofilament-light-chain-as-a-blood-biomarker-to-differentiate-30953863","doi":"10.1016/j.jpsychires.2019.03.019","journal":"Journal of psychiatric research","n_participants":null,"pmid":"30953863","source_url":"https://pubmed.ncbi.nlm.nih.gov/30953863/","study_design":null,"title":"Neurofilament light chain as a blood biomarker to differentiate psychiatric disorders from behavioural variant frontotemporal dementia","title_match":false,"year":2019},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/evaluation-of-a-previously-suggested-plasma-biomarker-panel-to-22279551","doi":"10.1371/journal.pone.0029868","journal":"PloS one","n_participants":142,"pmid":"22279551","source_url":"https://pubmed.ncbi.nlm.nih.gov/22279551/","study_design":null,"title":"Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease","title_match":true,"year":2012},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/small-rna-fingerprinting-of-alzheimer-s-disease-frontal-cortex-32922692","doi":"10.1080/20013078.2020.1766822","journal":"Journal of extracellular vesicles","n_participants":null,"pmid":"32922692","source_url":"https://pubmed.ncbi.nlm.nih.gov/32922692/","study_design":null,"title":"Small RNA fingerprinting of Alzheimer's disease frontal cortex extracellular vesicles and their comparison with peripheral extracellular vesicles","title_match":false,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-glial-fibrillary-acidic-protein-in-autosomal-dominant-36576155","doi":"10.1002/alz.12879","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"36576155","source_url":"https://pubmed.ncbi.nlm.nih.gov/36576155/","study_design":null,"title":"Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: Associations with A\u03b2-PET, neurodegeneration, and cognition","title_match":false,"year":2023},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/study-design-and-baseline-characteristics-of-a-population-based-33129280","doi":"10.1186/s12199-020-00903-3","journal":"Environmental health and preventive medicine","n_participants":11410,"pmid":"33129280","source_url":"https://pubmed.ncbi.nlm.nih.gov/33129280/","study_design":"cohort study","title":"Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD)","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-decade-of-blood-biomarkers-for-alzheimer-s-disease-research-an-29562526","doi":"10.3233/jad-170531","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"29562526","source_url":"https://pubmed.ncbi.nlm.nih.gov/29562526/","study_design":null,"title":"A Decade of Blood Biomarkers for Alzheimer's Disease Research: An Evolving Field, Improving Study Designs, and the Challenge of Replication","title_match":false,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-for-neurodegenerative-disorders-ready-for-prime-time-36607770","doi":"10.1097/yco.0000000000000851","journal":"Current opinion in psychiatry","n_participants":null,"pmid":"36607770","source_url":"https://pubmed.ncbi.nlm.nih.gov/36607770/","study_design":null,"title":"Plasma biomarkers for neurodegenerative disorders: ready for prime time?","title_match":true,"year":2023},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/a-blood-screening-test-for-alzheimer-s-disease-27453929","doi":"10.1016/j.dadm.2016.06.004","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":1329,"pmid":"27453929","source_url":"https://pubmed.ncbi.nlm.nih.gov/27453929/","study_design":null,"title":"A blood screening test for Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/neurogranin-and-tau-in-cerebrospinal-fluid-and-plasma-of-patients-28854881","doi":"10.1186/s12883-017-0945-8","journal":"BMC neurology","n_participants":50,"pmid":"28854881","source_url":"https://pubmed.ncbi.nlm.nih.gov/28854881/","study_design":null,"title":"Neurogranin and tau in cerebrospinal fluid and plasma of patients with acute ischemic stroke","title_match":false,"year":2017},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/longitudinal-blood-biomarker-trajectories-in-preclinical-alzheimer-s-37294682","doi":"10.1002/alz.13318","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":373,"pmid":"37294682","source_url":"https://pubmed.ncbi.nlm.nih.gov/37294682/","study_design":"longitudinal study","title":"Longitudinal blood biomarker trajectories in preclinical Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/plasma-transthyretin-as-a-candidate-marker-for-alzheimer-s-disease-22002789","doi":"10.3233/jad-2011-110611","journal":"Journal of Alzheimer's disease : JAD","n_participants":270,"pmid":"22002789","source_url":"https://pubmed.ncbi.nlm.nih.gov/22002789/","study_design":null,"title":"Plasma transthyretin as a candidate marker for Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/biomarker-potential-of-brain-secreted-extracellular-vesicles-in-blood-32211497","doi":"10.1002/dad2.12001","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"32211497","source_url":"https://pubmed.ncbi.nlm.nih.gov/32211497/","study_design":null,"title":"Biomarker potential of brain-secreted extracellular vesicles in blood in Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/from-cerebrospinal-fluid-to-blood-the-third-wave-of-fluid-biomarkers-29758941","doi":"10.3233/jad-179926","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"29758941","source_url":"https://pubmed.ncbi.nlm.nih.gov/29758941/","study_design":null,"title":"From Cerebrospinal Fluid to Blood: The Third Wave of Fluid Biomarkers for Alzheimer's Disease","title_match":false,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/aptamer-functionalized-carbon-nanotube-field-effect-transistor-35816677","doi":"10.1021/acssensors.2c00967","journal":"ACS sensors","n_participants":null,"pmid":"35816677","source_url":"https://pubmed.ncbi.nlm.nih.gov/35816677/","study_design":null,"title":"Aptamer-Functionalized Carbon Nanotube Field-Effect Transistor Biosensors for Alzheimer's Disease Serum Biomarker Detection","title_match":true,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-potential-clinical-value-of-plasma-biomarkers-in-alzheimer-s-37694991","doi":"10.1002/alz.13455","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37694991","source_url":"https://pubmed.ncbi.nlm.nih.gov/37694991/","study_design":null,"title":"The potential clinical value of plasma biomarkers in Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/serum-bdnf-as-a-potential-biomarker-of-alzheimer-s-disease-33967943","doi":"10.3389/fneur.2021.653267","journal":"Frontiers in neurology","n_participants":66,"pmid":"33967943","source_url":"https://pubmed.ncbi.nlm.nih.gov/33967943/","study_design":null,"title":"Serum BDNF as a Potential Biomarker of Alzheimer's Disease: Verification Through Assessment of Serum, Cerebrospinal Fluid, and Medial Temporal Lobe Atrophy","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-capacity-of-people-with-a-mental-disability-to-make-a-health-care-10824650","doi":"10.1017/s0033291700001768","journal":"Psychological medicine","n_participants":20,"pmid":"10824650","source_url":"https://pubmed.ncbi.nlm.nih.gov/10824650/","study_design":null,"title":"The capacity of people with a 'mental disability' to make a health care decision","title_match":false,"year":2000},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/emerging-blood-exosome-based-biomarkers-for-preclinical-and-clinical-35535875","doi":"10.4103/1673-5374.335832","journal":"Neural regeneration research","n_participants":null,"pmid":"35535875","source_url":"https://pubmed.ncbi.nlm.nih.gov/35535875/","study_design":"systematic review","title":"Emerging blood exosome-based biomarkers for preclinical and clinical Alzheimer's disease: a meta-analysis and systematic review","title_match":false,"year":2022},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/plasma-biomarker-profiles-in-autosomal-dominant-alzheimer-s-disease-36626935","doi":"10.1093/brain/awac399","journal":"Brain : a journal of neurology","n_participants":164,"pmid":"36626935","source_url":"https://pubmed.ncbi.nlm.nih.gov/36626935/","study_design":"longitudinal study","title":"Plasma biomarker profiles in autosomal dominant Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/stability-of-blood-based-biomarkers-of-alzheimer-s-disease-over-30211292","doi":"10.1016/j.dadm.2018.06.001","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":12,"pmid":"30211292","source_url":"https://pubmed.ncbi.nlm.nih.gov/30211292/","study_design":null,"title":"Stability of blood-based biomarkers of Alzheimer's disease over multiple freeze-thaw cycles","title_match":true,"year":2018},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/plasma-high-density-lipoprotein-cholesterol-and-risk-of-dementia-33964140","doi":"10.1093/cvr/cvab164","journal":"Cardiovascular research","n_participants":111,"pmid":"33964140","source_url":"https://pubmed.ncbi.nlm.nih.gov/33964140/","study_design":null,"title":"Plasma high-density lipoprotein cholesterol and risk of dementia: observational and genetic studies","title_match":false,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-associates-with-alzheimer-s-disease-31673598","doi":"10.1016/j.dadm.2019.08.002","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"31673598","source_url":"https://pubmed.ncbi.nlm.nih.gov/31673598/","study_design":"cross-sectional","title":"Plasma neurofilament light associates with Alzheimer's disease metabolic decline in amyloid-positive individuals","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/raman-spectroscopy-to-diagnose-alzheimer-s-disease-and-dementia-with-29865787","doi":"10.1021/acschemneuro.8b00198","journal":"ACS chemical neuroscience","n_participants":null,"pmid":"29865787","source_url":"https://pubmed.ncbi.nlm.nih.gov/29865787/","study_design":null,"title":"Raman Spectroscopy to Diagnose Alzheimer's Disease and Dementia with Lewy Bodies in Blood","title_match":false,"year":2018},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-biomarkers-and-their-current-use-in-clinical-39232196","doi":"10.1038/s41380-024-02709-z","journal":"Molecular psychiatry","n_participants":null,"pmid":"39232196","source_url":"https://pubmed.ncbi.nlm.nih.gov/39232196/","study_design":null,"title":"Alzheimer's disease biomarkers and their current use in clinical research and practice","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/technical-performance-evaluation-of-olink-proximity-extension-assay-35734478","doi":"10.3389/fneur.2022.889647","journal":"Frontiers in neurology","n_participants":54,"pmid":"35734478","source_url":"https://pubmed.ncbi.nlm.nih.gov/35734478/","study_design":"longitudinal study","title":"Technical Performance Evaluation of Olink Proximity Extension Assay for Blood-Based Biomarker Discovery in Longitudinal Studies of Alzheimer's Disease","title_match":true,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-for-alzheimer-s-pathology-and-the-diagnostic-32832590","doi":"10.1002/dad2.12081","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"32832590","source_url":"https://pubmed.ncbi.nlm.nih.gov/32832590/","study_design":null,"title":"Blood-based biomarkers for Alzheimer's pathology and the diagnostic process for a disease-modifying treatment: Projecting the impact on the cost and wait times","title_match":true,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/3alpha-5alpha-thp-a-potential-plasma-neurosteroid-biomarker-in-16231167","doi":"10.1007/s00213-005-0186-1","journal":"Psychopharmacology","n_participants":15,"pmid":"16231167","source_url":"https://pubmed.ncbi.nlm.nih.gov/16231167/","study_design":null,"title":"3alpha,5alpha-THP: a potential plasma neurosteroid biomarker in Alzheimer's disease and perhaps non-Alzheimer's dementia","title_match":false,"year":2006},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/association-between-increased-levels-of-amyloid-oligomers-in-plasma-31651358","doi":"10.1186/s13195-019-0535-7","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"31651358","source_url":"https://pubmed.ncbi.nlm.nih.gov/31651358/","study_design":"longitudinal study","title":"Association between increased levels of amyloid-\u03b2 oligomers in plasma and episodic memory loss in Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/neurofilament-light-in-serum-and-cerebrospinal-fluid-of-hip-fracture-30522125","doi":"10.1159/000494754","journal":"Dementia and geriatric cognitive disorders","n_participants":130,"pmid":"30522125","source_url":"https://pubmed.ncbi.nlm.nih.gov/30522125/","study_design":null,"title":"Neurofilament Light in Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium","title_match":false,"year":2018},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/amyloid-misfolding-as-a-plasma-biomarker-indicates-risk-for-future-33357241","doi":"10.1186/s13195-020-00738-8","journal":"Alzheimer's research & therapy","n_participants":203,"pmid":"33357241","source_url":"https://pubmed.ncbi.nlm.nih.gov/33357241/","study_design":null,"title":"Amyloid-\u03b2 misfolding as a plasma biomarker indicates risk for future clinical Alzheimer's disease in individuals with subjective cognitive decline","title_match":true,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/biomarkers-for-alzheimer-s-disease-in-plasma-serum-and-blood-23470193","doi":"10.1186/alzrt164","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"23470193","source_url":"https://pubmed.ncbi.nlm.nih.gov/23470193/","study_design":null,"title":"Biomarkers for Alzheimer's disease in plasma, serum and blood - conceptual and practical problems","title_match":false,"year":2013},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-involvement-of-lipids-in-alzheimer-s-disease-24894353","doi":"10.1016/j.jgg.2014.04.003","journal":"Journal of genetics and genomics = Yi chuan xue bao","n_participants":null,"pmid":"24894353","source_url":"https://pubmed.ncbi.nlm.nih.gov/24894353/","study_design":null,"title":"The involvement of lipids in Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/development-of-alzheimer-s-disease-biomarkers-from-csf-to-blood-based-35453600","doi":"10.3390/biomedicines10040850","journal":"Biomedicines","n_participants":null,"pmid":"35453600","source_url":"https://pubmed.ncbi.nlm.nih.gov/35453600/","study_design":null,"title":"Development of Alzheimer's Disease Biomarkers: From CSF- to Blood-Based Biomarkers","title_match":true,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/expected-wait-times-for-access-to-a-disease-modifying-alzheimer-s-34569686","doi":"10.1002/alz.12470","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"34569686","source_url":"https://pubmed.ncbi.nlm.nih.gov/34569686/","study_design":null,"title":"Expected wait times for access to a disease-modifying Alzheimer's treatment in the United States","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/transthyretin-decrease-in-plasma-of-mci-and-ad-patients-investigation-22698061","doi":"10.2174/156720512803251057","journal":"Current Alzheimer research","n_participants":55,"pmid":"22698061","source_url":"https://pubmed.ncbi.nlm.nih.gov/22698061/","study_design":null,"title":"Transthyretin decrease in plasma of MCI and AD patients: investigation of mechanisms for disease modulation","title_match":false,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/biofluid-based-biomarkers-for-alzheimer-s-disease-related-pathologies-35213777","doi":"10.1002/alz.12618","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"35213777","source_url":"https://pubmed.ncbi.nlm.nih.gov/35213777/","study_design":null,"title":"Biofluid-based biomarkers for Alzheimer's disease-related pathologies: An update and synthesis of the literature","title_match":false,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/relationship-of-serum-beta-synuclein-with-blood-biomarkers-and-brain-36129098","doi":"10.1002/alz.12790","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":374,"pmid":"36129098","source_url":"https://pubmed.ncbi.nlm.nih.gov/36129098/","study_design":null,"title":"Relationship of serum beta-synuclein with blood biomarkers and brain atrophy","title_match":false,"year":2023},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/current-trends-in-blood-biomarker-detection-and-imaging-for-alzheimer-35460969","doi":"10.1016/j.bios.2022.114278","journal":"Biosensors & bioelectronics","n_participants":null,"pmid":"35460969","source_url":"https://pubmed.ncbi.nlm.nih.gov/35460969/","study_design":null,"title":"Current trends in blood biomarker detection and imaging for Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/biomarkers-of-alzheimer-s-disease-and-neurodegeneration-in-dried-38284555","doi":"10.1002/alz.13697","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":154,"pmid":"38284555","source_url":"https://pubmed.ncbi.nlm.nih.gov/38284555/","study_design":null,"title":"Biomarkers of Alzheimer's disease and neurodegeneration in dried blood spots-A new collection method for remote settings","title_match":false,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/ultrasensitive-detection-of-plasma-amyloid-as-a-biomarker-for-31424403","doi":"10.3233/jad-190533","journal":"Journal of Alzheimer's disease : JAD","n_participants":32,"pmid":"31424403","source_url":"https://pubmed.ncbi.nlm.nih.gov/31424403/","study_design":null,"title":"Ultrasensitive Detection of Plasma Amyloid-\u03b2 as a Biomarker for Cognitively Normal Elderly Individuals at Risk of Alzheimer's Disease","title_match":true,"year":2019},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/effect-of-renal-function-on-the-diagnostic-performance-of-plasma-37009461","doi":"10.3389/fnagi.2023.1150510","journal":"Frontiers in aging neuroscience","n_participants":645,"pmid":"37009461","source_url":"https://pubmed.ncbi.nlm.nih.gov/37009461/","study_design":"cross-sectional","title":"Effect of renal function on the diagnostic performance of plasma biomarkers for Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/blood-amyloid-oligomerization-as-a-biomarker-of-alzheimer-s-disease-a-32310175","doi":"10.3233/jad-200061","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"32310175","source_url":"https://pubmed.ncbi.nlm.nih.gov/32310175/","study_design":null,"title":"Blood Amyloid-\u03b2 Oligomerization as a Biomarker of Alzheimer's Disease: A Blinded Validation Study","title_match":false,"year":2020},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/alzheimer-s-polygenic-risk-scores-apoe-alzheimer-s-disease-risk-and-37516890","doi":"10.1186/s13195-023-01277-8","journal":"Alzheimer's research & therapy","n_participants":712,"pmid":"37516890","source_url":"https://pubmed.ncbi.nlm.nih.gov/37516890/","study_design":"cohort study","title":"Alzheimer's polygenic risk scores, APOE, Alzheimer's disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-identify-older-adults-at-risk-of-alzheimer-s-36876954","doi":"10.1002/alz.12986","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":847,"pmid":"36876954","source_url":"https://pubmed.ncbi.nlm.nih.gov/36876954/","study_design":null,"title":"Plasma biomarkers identify older adults at risk of Alzheimer's disease and related dementias in a real-world population-based cohort","title_match":true,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/blood-protein-markers-of-neocortical-amyloid-burden-a-candidate-study-25881911","doi":"10.3233/jad-150020","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"25881911","source_url":"https://pubmed.ncbi.nlm.nih.gov/25881911/","study_design":null,"title":"Blood Protein Markers of Neocortical Amyloid-\u03b2 Burden: A Candidate Study Using SOMAscan Technology","title_match":false,"year":2015},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/identification-of-a-blood-based-biomarker-panel-for-classification-of-21466745","doi":"10.1017/s1461145711000459","journal":"The international journal of neuropsychopharmacology","n_participants":155,"pmid":"21466745","source_url":"https://pubmed.ncbi.nlm.nih.gov/21466745/","study_design":null,"title":"Identification of a blood-based biomarker panel for classification of Alzheimer's disease","title_match":true,"year":2011},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/utility-of-different-mr-modalities-in-mild-cognitive-impairment-and-18692749","doi":"10.1016/j.acra.2008.04.008","journal":"Academic radiology","n_participants":54,"pmid":"18692749","source_url":"https://pubmed.ncbi.nlm.nih.gov/18692749/","study_design":"longitudinal study","title":"Utility of different MR modalities in mild cognitive impairment and its use as a predictor of conversion to probable dementia","title_match":false,"year":2008},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/blood-based-neurochemical-diagnosis-of-vascular-dementia-a-pilot-study-17662050","doi":"10.1111/j.1471-4159.2007.04763.x","journal":"Journal of neurochemistry","n_participants":15,"pmid":"17662050","source_url":"https://pubmed.ncbi.nlm.nih.gov/17662050/","study_design":null,"title":"Blood-based neurochemical diagnosis of vascular dementia: a pilot study","title_match":false,"year":2007},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-and-inflammatory-biomarkers-positively-correlate-38011580","doi":"10.1002/alz.13485","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":837,"pmid":"38011580","source_url":"https://pubmed.ncbi.nlm.nih.gov/38011580/","study_design":null,"title":"Alzheimer's disease and inflammatory biomarkers positively correlate in plasma in the UK-ADRC cohort","title_match":false,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/a-novel-blood-test-for-the-early-detection-of-alzheimer-s-disease-20930265","doi":"10.3233/jad-2010-101521","journal":"Journal of Alzheimer's disease : JAD","n_participants":74,"pmid":"20930265","source_url":"https://pubmed.ncbi.nlm.nih.gov/20930265/","study_design":null,"title":"A novel blood test for the early detection of Alzheimer's disease","title_match":true,"year":2011},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-217-exhibits-sex-specific-prognostication-37639492","doi":"10.1002/alz.13454","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":163,"pmid":"37639492","source_url":"https://pubmed.ncbi.nlm.nih.gov/37639492/","study_design":"longitudinal study","title":"Plasma phosphorylated tau-217 exhibits sex-specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults","title_match":false,"year":2024},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-for-alzheimer-s-disease-and-related-disorders-35470421","doi":"10.1111/ane.13628","journal":"Acta neurologica Scandinavica","n_participants":null,"pmid":"35470421","source_url":"https://pubmed.ncbi.nlm.nih.gov/35470421/","study_design":null,"title":"Blood biomarkers for Alzheimer's disease and related disorders","title_match":false,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/blood-based-biomarker-candidates-of-cerebral-amyloid-using-pib-pet-in-27031486","doi":"10.3233/jad-151155","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"27031486","source_url":"https://pubmed.ncbi.nlm.nih.gov/27031486/","study_design":"longitudinal study","title":"Blood-Based Biomarker Candidates of Cerebral Amyloid Using PiB PET in Non-Demented Elderly","title_match":true,"year":2016},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/levels-of-alzheimer-s-disease-blood-biomarkers-are-altered-after-food-37243891","doi":"10.1002/alz.13163","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37243891","source_url":"https://pubmed.ncbi.nlm.nih.gov/37243891/","study_design":null,"title":"Levels of Alzheimer's disease blood biomarkers are altered after food intake-A pilot intervention study in healthy adults","title_match":false,"year":2023},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/timing-of-changes-in-alzheimer-s-disease-plasma-biomarkers-as-40539416","doi":"10.1002/ana.27285","journal":"Annals of neurology","n_participants":784,"pmid":"40539416","source_url":"https://pubmed.ncbi.nlm.nih.gov/40539416/","study_design":"longitudinal study","title":"Timing of Changes in Alzheimer's Disease Plasma Biomarkers as Assessed by Amyloid and Tau PET Clocks","title_match":true,"year":2025},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/racial-and-ethnic-differences-in-plasma-biomarker-eligibility-for-a-38629508","doi":"10.1002/alz.13803","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":4905,"pmid":"38629508","source_url":"https://pubmed.ncbi.nlm.nih.gov/38629508/","study_design":null,"title":"Racial and ethnic differences in plasma biomarker eligibility for a preclinical Alzheimer's disease trial","title_match":true,"year":2024},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/development-of-an-ultra-high-sensitive-immunoassay-with-plasma-27278241","doi":"10.1186/s12951-016-0198-5","journal":"Journal of nanobiotechnology","n_participants":null,"pmid":"27278241","source_url":"https://pubmed.ncbi.nlm.nih.gov/27278241/","study_design":null,"title":"Development of an ultra-high sensitive immunoassay with plasma biomarker for differentiating Parkinson disease dementia from Parkinson disease using antibody functionalized magnetic nanoparticles","title_match":true,"year":2016},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/serum-neurofilament-light-chain-level-as-a-predictor-of-cognitive-34996525","doi":"10.1186/s13195-021-00953-x","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"34996525","source_url":"https://pubmed.ncbi.nlm.nih.gov/34996525/","study_design":null,"title":"Serum neurofilament light chain level as a predictor of cognitive stage transition","title_match":false,"year":2022},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/plasma-gfap-nfl-and-ptau-181-detect-preclinical-stages-of-dementia-38654932","doi":"10.3389/fendo.2024.1375302","journal":"Frontiers in endocrinology","n_participants":152,"pmid":"38654932","source_url":"https://pubmed.ncbi.nlm.nih.gov/38654932/","study_design":null,"title":"Plasma GFAP, NfL and pTau 181 detect preclinical stages of dementia","title_match":true,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/modeling-the-temporal-evolution-of-plasma-p-tau-in-relation-to-37963289","doi":"10.1002/alz.13539","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1408,"pmid":"37963289","source_url":"https://pubmed.ncbi.nlm.nih.gov/37963289/","study_design":null,"title":"Modeling the temporal evolution of plasma p-tau in relation to amyloid beta and tau PET","title_match":true,"year":2024},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/nanosensor-driven-detection-of-neuron-derived-exosomal-a-42-with-36943894","doi":"10.1021/acs.analchem.2c05751","journal":"Analytical chemistry","n_participants":27,"pmid":"36943894","source_url":"https://pubmed.ncbi.nlm.nih.gov/36943894/","study_design":null,"title":"Nanosensor-Driven Detection of Neuron-Derived Exosomal A\u03b2 42 with Graphene Electrolyte-Gated Transistor for Alzheimer's Disease Diagnosis","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/identification-of-cathepsin-d-as-a-plasma-biomarker-for-alzheimer-s-33445607","doi":"10.3390/cells10010138","journal":"Cells","n_participants":null,"pmid":"33445607","source_url":"https://pubmed.ncbi.nlm.nih.gov/33445607/","study_design":null,"title":"Identification of Cathepsin D as a Plasma Biomarker for Alzheimer's Disease","title_match":true,"year":2021},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/plasma-dyrk1a-as-a-novel-risk-factor-for-alzheimer-s-disease-25116835","doi":"10.1038/tp.2014.61","journal":"Translational psychiatry","n_participants":26,"pmid":"25116835","source_url":"https://pubmed.ncbi.nlm.nih.gov/25116835/","study_design":null,"title":"Plasma DYRK1A as a novel risk factor for Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/dynamics-of-plasma-biomarkers-in-down-syndrome-the-relative-levels-of-32192521","doi":"10.1186/s13195-020-00593-7","journal":"Alzheimer's research & therapy","n_participants":100,"pmid":"32192521","source_url":"https://pubmed.ncbi.nlm.nih.gov/32192521/","study_design":"longitudinal study","title":"Dynamics of plasma biomarkers in Down syndrome: the relative levels of A\u03b242 decrease with age, whereas NT1 tau and NfL increase","title_match":true,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/impact-of-pre-analytical-sample-handling-factors-on-plasma-biomarkers-36625424","doi":"10.1111/jnc.15757","journal":"Journal of neurochemistry","n_participants":null,"pmid":"36625424","source_url":"https://pubmed.ncbi.nlm.nih.gov/36625424/","study_design":null,"title":"Impact of pre-analytical sample handling factors on plasma biomarkers of Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/amyloid-as-a-blood-biomarker-for-alzheimer-s-disease-a-review-of-31868667","doi":"10.3233/jad-190714","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"31868667","source_url":"https://pubmed.ncbi.nlm.nih.gov/31868667/","study_design":null,"title":"Amyloid-\u03b2 as a Blood Biomarker for Alzheimer's Disease: A Review of Recent Literature","title_match":false,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/solanezumab-for-alzheimer-s-disease-21504387","doi":"10.1517/14712598.2011.578573","journal":"Expert opinion on biological therapy","n_participants":null,"pmid":"21504387","source_url":"https://pubmed.ncbi.nlm.nih.gov/21504387/","study_design":null,"title":"Solanezumab for Alzheimer's disease","title_match":false,"year":2011},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/a-and-tau-structure-based-biomarkers-for-a-blood-and-csf-based-two-30911600","doi":"10.1016/j.dadm.2019.01.008","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"30911600","source_url":"https://pubmed.ncbi.nlm.nih.gov/30911600/","study_design":null,"title":"A\u03b2 and tau structure-based biomarkers for a blood- and CSF-based two-step recruitment strategy to identify patients with dementia due to Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/a-longitudinal-study-of-plasma-ptau181-in-mild-cognitive-impairment-35318733","doi":"10.1002/mds.28994","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"35318733","source_url":"https://pubmed.ncbi.nlm.nih.gov/35318733/","study_design":"longitudinal study","title":"A Longitudinal Study of Plasma pTau181 in Mild Cognitive Impairment with Lewy Bodies and Alzheimer's Disease","title_match":true,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/novel-blood-test-for-early-biomarkers-of-preeclampsia-and-alzheimer-s-34354200","doi":"10.1038/s41598-021-95611-5","journal":"Scientific reports","n_participants":33,"pmid":"34354200","source_url":"https://pubmed.ncbi.nlm.nih.gov/34354200/","study_design":null,"title":"Novel blood test for early biomarkers of preeclampsia and Alzheimer's disease","title_match":true,"year":2021},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/soluble-amyloid-precursor-protein-as-blood-based-biomarker-of-23423136","doi":"10.1038/tp.2013.11","journal":"Translational psychiatry","n_participants":80,"pmid":"23423136","source_url":"https://pubmed.ncbi.nlm.nih.gov/23423136/","study_design":null,"title":"Soluble amyloid precursor protein \u03b2 as blood-based biomarker of Alzheimer's disease","title_match":true,"year":2013},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-for-alzheimer-disease-mapping-the-road-to-the-30297701","doi":"10.1038/s41582-018-0079-7","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"30297701","source_url":"https://pubmed.ncbi.nlm.nih.gov/30297701/","study_design":null,"title":"Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic","title_match":true,"year":2018},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/blood-plasma-phosphorylated-tau-isoforms-track-cns-change-in-32725127","doi":"10.1084/jem.20200861","journal":"The Journal of experimental medicine","n_participants":36,"pmid":"32725127","source_url":"https://pubmed.ncbi.nlm.nih.gov/32725127/","study_design":null,"title":"Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/increasing-participant-diversity-in-ad-research-plans-for-digital-36209495","doi":"10.1002/alz.12797","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":20000,"pmid":"36209495","source_url":"https://pubmed.ncbi.nlm.nih.gov/36209495/","study_design":"longitudinal study","title":"Increasing participant diversity in AD research: Plans for digital screening, blood testing, and a community-engaged approach in the Alzheimer's Disease Neuroimaging Initiative 4","title_match":false,"year":2023},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/primary-care-detection-of-alzheimer-s-disease-using-a-self-40954312","doi":"10.1038/s41591-025-03965-4","journal":"Nature medicine","n_participants":223,"pmid":"40954312","source_url":"https://pubmed.ncbi.nlm.nih.gov/40954312/","study_design":null,"title":"Primary care detection of Alzheimer's disease using a self-administered digital cognitive test and blood biomarkers","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/portable-electrochemical-micro-workstation-platform-for-simultaneous-35129691","doi":"10.1007/s00604-022-05199-4","journal":"Mikrochimica acta","n_participants":null,"pmid":"35129691","source_url":"https://pubmed.ncbi.nlm.nih.gov/35129691/","study_design":null,"title":"Portable electrochemical micro-workstation platform for simultaneous detection of multiple Alzheimer's disease biomarkers","title_match":false,"year":2022},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/scalable-plasma-and-digital-cognitive-markers-for-diagnosis-and-38224278","doi":"10.1002/alz.13686","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":49,"pmid":"38224278","source_url":"https://pubmed.ncbi.nlm.nih.gov/38224278/","study_design":null,"title":"Scalable plasma and digital cognitive markers for diagnosis and prognosis of Alzheimer's disease and related dementias","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/validation-deployment-and-real-world-implementation-of-a-modular-38374739","doi":"10.14283/jpad.2024.32","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"38374739","source_url":"https://pubmed.ncbi.nlm.nih.gov/38374739/","study_design":null,"title":"Validation, Deployment, and Real-World Implementation of a Modular Toolbox for Alzheimer's Disease Detection and Dementia Risk Reduction: The AD-RIDDLE Project","title_match":false,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/relationship-of-plasma-biomarkers-to-digital-cognitive-tests-in-38623387","doi":"10.1002/dad2.12590","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":46,"pmid":"38623387","source_url":"https://pubmed.ncbi.nlm.nih.gov/38623387/","study_design":null,"title":"Relationship of plasma biomarkers to digital cognitive tests in Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/genome-wide-association-study-identifies-four-novel-loci-associated-28247064","doi":"10.1007/s00401-017-1685-y","journal":"Acta neuropathologica","n_participants":3146,"pmid":"28247064","source_url":"https://pubmed.ncbi.nlm.nih.gov/28247064/","study_design":"case-control study","title":"Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers","title_match":false,"year":2017},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/an-examination-of-a-novel-multipanel-of-csf-biomarkers-in-the-33336877","doi":"10.1002/alz.12204","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":720,"pmid":"33336877","source_url":"https://pubmed.ncbi.nlm.nih.gov/33336877/","study_design":null,"title":"An examination of a novel multipanel of CSF biomarkers in the Alzheimer's disease clinical and pathological continuum","title_match":false,"year":2021},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/multiplex-proteomics-identifies-novel-csf-and-plasma-biomarkers-of-31694701","doi":"10.1186/s40478-019-0795-2","journal":"Acta neuropathologica communications","n_participants":59,"pmid":"31694701","source_url":"https://pubmed.ncbi.nlm.nih.gov/31694701/","study_design":null,"title":"Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer's disease","title_match":true,"year":2019},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/biomarker-modeling-of-alzheimer-s-disease-using-pet-based-braak-37118445","doi":"10.1038/s43587-022-00204-0","journal":"Nature aging","n_participants":159,"pmid":"37118445","source_url":"https://pubmed.ncbi.nlm.nih.gov/37118445/","study_design":null,"title":"Biomarker modeling of Alzheimer's disease using PET-based Braak staging","title_match":false,"year":2022},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/accelerating-alzheimer-s-therapeutic-development-the-past-and-future-37848035","doi":"10.1016/j.cell.2023.09.023","journal":"Cell","n_participants":null,"pmid":"37848035","source_url":"https://pubmed.ncbi.nlm.nih.gov/37848035/","study_design":"clinical trial","title":"Accelerating Alzheimer's therapeutic development: The past and future of clinical trials","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/mild-behavioral-impairment-and-its-relation-to-tau-pathology-in-33500386","doi":"10.1038/s41398-021-01206-z","journal":"Translational psychiatry","n_participants":null,"pmid":"33500386","source_url":"https://pubmed.ncbi.nlm.nih.gov/33500386/","study_design":null,"title":"Mild behavioral impairment and its relation to tau pathology in preclinical Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-tau-and-ptau-181-increase-with-cortical-amyloid-20049742","doi":"10.1002/emmm.200900048","journal":"EMBO molecular medicine","n_participants":null,"pmid":"20049742","source_url":"https://pubmed.ncbi.nlm.nih.gov/20049742/","study_design":null,"title":"Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease","title_match":false,"year":2009},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/gantenerumab-a-novel-human-anti-a-antibody-demonstrates-sustained-21955818","doi":"10.3233/jad-2011-110977","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"21955818","source_url":"https://pubmed.ncbi.nlm.nih.gov/21955818/","study_design":null,"title":"Gantenerumab: a novel human anti-A\u03b2 antibody demonstrates sustained cerebral amyloid-\u03b2 binding and elicits cell-mediated removal of human amyloid-\u03b2","title_match":false,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/anti-amyloid-antibody-therapies-in-alzheimer-s-disease-36655336","doi":"10.1093/brain/awad005","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"36655336","source_url":"https://pubmed.ncbi.nlm.nih.gov/36655336/","study_design":null,"title":"Anti-amyloid antibody therapies in Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/safety-and-tolerability-of-ban2401-a-clinical-study-in-alzheimer-s-27048170","doi":"10.1186/s13195-016-0181-2","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"27048170","source_url":"https://pubmed.ncbi.nlm.nih.gov/27048170/","study_design":null,"title":"Safety and tolerability of BAN2401--a clinical study in Alzheimer's disease with a protofibril selective A\u03b2 antibody","title_match":false,"year":2016},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/bapineuzumab-and-solanezumab-for-alzheimer-s-disease-is-the-amyloid-23574434","doi":"10.1517/14712598.2013.789856","journal":"Expert opinion on biological therapy","n_participants":null,"pmid":"23574434","source_url":"https://pubmed.ncbi.nlm.nih.gov/23574434/","study_design":null,"title":"Bapineuzumab and solanezumab for Alzheimer's disease: is the 'amyloid cascade hypothesis' still alive?","title_match":false,"year":2013},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/first-in-human-safety-and-long-term-exposure-data-for-aab-003-pf-26925577","doi":"10.1186/s13195-016-0177-y","journal":"Alzheimer's research & therapy","n_participants":52,"pmid":"26925577","source_url":"https://pubmed.ncbi.nlm.nih.gov/26925577/","study_design":"open-label trial","title":"First-In-Human safety and long-term exposure data for AAB-003 (PF-05236812) and biomarkers after intravenous infusions of escalating doses in patients with mild to moderate Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/effects-of-oral-alz-801-valiltramiprosate-on-plasma-biomarkers-brain-38902571","doi":"10.1007/s40265-024-02067-8","journal":"Drugs","n_participants":80,"pmid":"38902571","source_url":"https://pubmed.ncbi.nlm.nih.gov/38902571/","study_design":"clinical trial","title":"Effects of Oral ALZ-801/Valiltramiprosate on Plasma Biomarkers, Brain Hippocampal Volume, and Cognition: Results of 2-Year Single-Arm, Open-Label, Phase 2 Trial in APOE4 Carriers with Early Alzheimer's Disease","title_match":true,"year":2024},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/prognostic-and-predictive-factors-in-early-alzheimer-s-disease-a-38405341","doi":"10.3233/adr-230045","journal":"Journal of Alzheimer's disease reports","n_participants":null,"pmid":"38405341","source_url":"https://pubmed.ncbi.nlm.nih.gov/38405341/","study_design":null,"title":"Prognostic and Predictive Factors in Early Alzheimer's Disease: A Systematic Review","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/a-combined-physiologically-based-pharmacokinetic-and-quantitative-36632701","doi":"10.1002/psp4.12912","journal":"CPT: pharmacometrics & systems pharmacology","n_participants":null,"pmid":"36632701","source_url":"https://pubmed.ncbi.nlm.nih.gov/36632701/","study_design":null,"title":"A combined physiologically-based pharmacokinetic and quantitative systems pharmacology model for modeling amyloid aggregation in Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/sar228810-an-antibody-for-protofibrillar-amyloid-peptide-designed-to-30486882","doi":"10.1186/s13195-018-0447-y","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"30486882","source_url":"https://pubmed.ncbi.nlm.nih.gov/30486882/","study_design":null,"title":"SAR228810: an antibody for protofibrillar amyloid \u03b2 peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA)","title_match":false,"year":2018},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/lecanemab-treatment-for-alzheimer-s-disease-of-varying-severities-and-41070709","doi":"10.1002/alz.70750","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":68,"pmid":"41070709","source_url":"https://pubmed.ncbi.nlm.nih.gov/41070709/","study_design":"cohort study","title":"Lecanemab treatment for Alzheimer's Disease of varying severities and associated plasma biomarkers monitoring: A multi-center real-world study in China","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/quantitative-systems-pharmacology-based-exploration-of-relevant-anti-38774587","doi":"10.1002/trc2.12474","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":null,"pmid":"38774587","source_url":"https://pubmed.ncbi.nlm.nih.gov/38774587/","study_design":null,"title":"Quantitative systems pharmacology-based exploration of relevant anti-amyloid therapy challenges in clinical practice","title_match":false,"year":2024},{"alzhub_score":84,"alzhub_url":"https://alzhub.org/study/japanese-subgroup-analyses-from-emerge-and-engage-phase-3-clinical-39350371","doi":"10.14283/jpad.2024.106","journal":"The journal of prevention of Alzheimer's disease","n_participants":121,"pmid":"39350371","source_url":"https://pubmed.ncbi.nlm.nih.gov/39350371/","study_design":"clinical trial","title":"Japanese Subgroup Analyses from EMERGE and ENGAGE, Phase 3 Clinical Trials of Aducanumab in Patients with Early Alzheimer's Disease","title_match":false,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/real-world-experience-with-baseline-characteristics-and-safety-of-41396015","doi":"10.1177/13872877251406619","journal":"Journal of Alzheimer's disease : JAD","n_participants":190,"pmid":"41396015","source_url":"https://pubmed.ncbi.nlm.nih.gov/41396015/","study_design":null,"title":"Real-world experience with baseline characteristics and safety of lecanemab for Alzheimer's disease in Eastern China","title_match":false,"year":2026},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/higher-phosphorylated-tau-levels-predict-cognitive-decline-and-41276859","doi":"10.1186/s13195-025-01912-6","journal":"Alzheimer's research & therapy","n_participants":234,"pmid":"41276859","source_url":"https://pubmed.ncbi.nlm.nih.gov/41276859/","study_design":"longitudinal study","title":"Higher phosphorylated tau levels predict cognitive decline and amyloid-related imaging abnormalities during lecanemab treatment: clinical practice data","title_match":false,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/biomarkers-of-alzheimer-s-disease-among-mexican-americans-23313927","doi":"10.3233/jad-122074","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"23313927","source_url":"https://pubmed.ncbi.nlm.nih.gov/23313927/","study_design":null,"title":"Biomarkers of Alzheimer's disease among Mexican Americans","title_match":false,"year":2013},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/amyloid-beta-peptides-in-human-plasma-and-tissues-and-their-19118806","doi":"10.1016/j.jalz.2008.10.004","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"19118806","source_url":"https://pubmed.ncbi.nlm.nih.gov/19118806/","study_design":"longitudinal study","title":"Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease","title_match":false,"year":2009},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/metformin-in-amnestic-mild-cognitive-impairment-results-of-a-pilot-26890736","doi":"10.3233/jad-150493","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"26890736","source_url":"https://pubmed.ncbi.nlm.nih.gov/26890736/","study_design":null,"title":"Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial","title_match":false,"year":2016},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/age-but-not-diagnosis-is-the-main-predictor-of-plasma-amyloid-beta-12873852","doi":"10.1001/archneur.60.7.958","journal":"Archives of neurology","n_participants":146,"pmid":"12873852","source_url":"https://pubmed.ncbi.nlm.nih.gov/12873852/","study_design":null,"title":"Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels","title_match":true,"year":2003},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/physical-activity-and-amyloid-plasma-and-brain-levels-results-from-22889922","doi":"10.1038/mp.2012.107","journal":"Molecular psychiatry","n_participants":116,"pmid":"22889922","source_url":"https://pubmed.ncbi.nlm.nih.gov/22889922/","study_design":null,"title":"Physical activity and amyloid-\u03b2 plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing","title_match":false,"year":2013},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/does-severity-of-alzheimer-s-disease-contribute-to-its-responsiveness-30158897","doi":"10.3389/fneur.2018.00662","journal":"Frontiers in neurology","n_participants":null,"pmid":"30158897","source_url":"https://pubmed.ncbi.nlm.nih.gov/30158897/","study_design":null,"title":"Does Severity of Alzheimer's Disease Contribute to Its Responsiveness to Modifying Gut Microbiota? A Double Blind Clinical Trial","title_match":false,"year":2018},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/prognostic-serum-mirna-biomarkers-associated-with-alzheimer-s-disease-25349172","doi":"10.1038/mp.2014.127","journal":"Molecular psychiatry","n_participants":49,"pmid":"25349172","source_url":"https://pubmed.ncbi.nlm.nih.gov/25349172/","study_design":null,"title":"Prognostic serum miRNA biomarkers associated with Alzheimer's disease shows concordance with neuropsychological and neuroimaging assessment","title_match":false,"year":2015},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-40-42-ratio-predicts-cerebral-amyloidosis-in-31113759","doi":"10.1016/j.jalz.2019.03.009","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":276,"pmid":"31113759","source_url":"https://pubmed.ncbi.nlm.nih.gov/31113759/","study_design":"cohort study","title":"Plasma amyloid \u03b2 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease","title_match":true,"year":2019},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/down-syndrome-partial-trisomy-21-and-absence-of-alzheimer-s-disease-27983553","doi":"10.3233/jad-160836","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"27983553","source_url":"https://pubmed.ncbi.nlm.nih.gov/27983553/","study_design":null,"title":"Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer's Disease: The Role of APP","title_match":false,"year":2017},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/p-tau217-correlates-with-neurodegeneration-in-alzheimer-s-disease-and-38513667","doi":"10.1016/j.neuron.2024.02.017","journal":"Neuron","n_participants":null,"pmid":"38513667","source_url":"https://pubmed.ncbi.nlm.nih.gov/38513667/","study_design":null,"title":"P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy","title_match":true,"year":2024},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-in-alzheimer-s-disease-lumipulse-and-alzpath-simoa-39679606","doi":"10.1093/brain/awae368","journal":"Brain : a journal of neurology","n_participants":392,"pmid":"39679606","source_url":"https://pubmed.ncbi.nlm.nih.gov/39679606/","study_design":null,"title":"Plasma p-tau217 in Alzheimer's disease: Lumipulse and ALZpath SIMOA head-to-head comparison","title_match":true,"year":2025},{"alzhub_score":91,"alzhub_url":"https://alzhub.org/study/donanemab-in-preclinical-alzheimer-s-disease-screening-and-baseline-40955720","doi":"10.1002/alz.70662","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":63124,"pmid":"40955720","source_url":"https://pubmed.ncbi.nlm.nih.gov/40955720/","study_design":"longitudinal study","title":"Donanemab in preclinical Alzheimer's disease: Screening and baseline data from TRAILBLAZER-ALZ 3","title_match":false,"year":2025},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/donanemab-treatment-effect-by-baseline-tau-burden-and-disease-42273802","doi":"10.1002/alz.71577","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"42273802","source_url":"https://pubmed.ncbi.nlm.nih.gov/42273802/","study_design":null,"title":"Donanemab treatment effect by baseline tau burden and disease severity: Observations from the TRAILBLAZER-ALZ 2 trial","title_match":false,"year":2026},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/p-tau217-in-alzheimer-s-disease-35341762","doi":"10.1016/j.cca.2022.03.018","journal":"Clinica chimica acta; international journal of clinical chemistry","n_participants":null,"pmid":"35341762","source_url":"https://pubmed.ncbi.nlm.nih.gov/35341762/","study_design":"systematic review","title":"P-tau217 in Alzheimer's disease","title_match":true,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/fully-synthetic-phosphorylated-tau181-tau217-and-tau231-calibrators-38288278","doi":"10.3389/fnagi.2023.1340706","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"38288278","source_url":"https://pubmed.ncbi.nlm.nih.gov/38288278/","study_design":null,"title":"Fully synthetic phosphorylated Tau181, Tau217, and Tau231 calibrators for Alzheimer's disease diagnosis","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/differences-between-plasma-and-cerebrospinal-fluid-p-tau181-and-p-35404280","doi":"10.3233/jad-215646","journal":"Journal of Alzheimer's disease : JAD","n_participants":91,"pmid":"35404280","source_url":"https://pubmed.ncbi.nlm.nih.gov/35404280/","study_design":"cross-sectional","title":"Differences Between Plasma and Cerebrospinal Fluid p-tau181 and p-tau231 in Early Alzheimer's Disease","title_match":true,"year":2022},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/phosphorylated-tau-in-alzheimer-s-disease-37852722","doi":"10.1016/bs.acc.2023.05.001","journal":"Advances in clinical chemistry","n_participants":null,"pmid":"37852722","source_url":"https://pubmed.ncbi.nlm.nih.gov/37852722/","study_design":"systematic review","title":"Phosphorylated tau in Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/which-plasma-ptau217-assay-should-i-use-in-clinical-practice-pandora-39797604","doi":"10.1093/brain/awaf007","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"39797604","source_url":"https://pubmed.ncbi.nlm.nih.gov/39797604/","study_design":null,"title":"Which plasma pTau217 assay should I use in clinical practice? Pandora's box demystified","title_match":true,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-and-gfap-predict-widespread-cognitive-decline-in-41402627","doi":"10.1007/s00415-025-13556-5","journal":"Journal of neurology","n_participants":136,"pmid":"41402627","source_url":"https://pubmed.ncbi.nlm.nih.gov/41402627/","study_design":null,"title":"Plasma p-Tau217 and GFAP predict widespread cognitive decline in Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/als-plasma-biomarkers-reveal-neurofilament-and-ptau-correlate-with-39913612","doi":"10.1002/acn3.70001","journal":"Annals of clinical and translational neurology","n_participants":86,"pmid":"39913612","source_url":"https://pubmed.ncbi.nlm.nih.gov/39913612/","study_design":null,"title":"ALS plasma biomarkers reveal neurofilament and pTau correlate with disease onset and progression","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/evaluating-p-tau217-and-p-tau231-as-biomarkers-for-early-diagnosis-38672142","doi":"10.3390/biomedicines12040786","journal":"Biomedicines","n_participants":null,"pmid":"38672142","source_url":"https://pubmed.ncbi.nlm.nih.gov/38672142/","study_design":"narrative review","title":"Evaluating p-tau217 and p-tau231 as Biomarkers for Early Diagnosis and Differentiation of Alzheimer's Disease: A Narrative Review","title_match":true,"year":2024},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-for-early-detection-of-alzheimer-s-disease-a-cross-40483474","doi":"10.1186/s13195-025-01778-8","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"40483474","source_url":"https://pubmed.ncbi.nlm.nih.gov/40483474/","study_design":"cross-sectional","title":"Plasma biomarkers for early detection of alzheimer's disease: a cross-sectional study in a Japanese cohort","title_match":true,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/phospho-specific-plasma-p-tau181-assay-detects-clinical-as-well-as-35502634","doi":"10.1002/acn3.51553","journal":"Annals of clinical and translational neurology","n_participants":69,"pmid":"35502634","source_url":"https://pubmed.ncbi.nlm.nih.gov/35502634/","study_design":null,"title":"Phospho-specific plasma p-tau181 assay detects clinical as well as asymptomatic Alzheimer's disease","title_match":true,"year":2022},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/effectiveness-safety-and-biomarker-dynamics-of-lecanemab-in-chinese-41823189","doi":"10.1002/alz.71231","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"41823189","source_url":"https://pubmed.ncbi.nlm.nih.gov/41823189/","study_design":null,"title":"Effectiveness, safety, and biomarker dynamics of lecanemab in Chinese Alzheimer's disease population: a multicenter real-world study","title_match":false,"year":2026},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/head-to-head-comparison-of-brain-derived-ptau217-and-total-ptau217-41770931","doi":"10.1073/pnas.2536792123","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"41770931","source_url":"https://pubmed.ncbi.nlm.nih.gov/41770931/","study_design":null,"title":"Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classification","title_match":true,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/biomarker-related-phospho-tau217-appears-in-synapses-around-a-plaques-40902589","doi":"10.1016/j.celrep.2025.116203","journal":"Cell reports","n_participants":null,"pmid":"40902589","source_url":"https://pubmed.ncbi.nlm.nih.gov/40902589/","study_design":null,"title":"Biomarker-related phospho-tau217 appears in synapses around A\u03b2 plaques prior to tau tangle in cerebral cortex of preclinical Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/a-head-to-head-comparison-of-plasma-biomarkers-to-detect-alzheimer-s-39998475","doi":"10.1002/alz.14609","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":197,"pmid":"39998475","source_url":"https://pubmed.ncbi.nlm.nih.gov/39998475/","study_design":"cross-sectional","title":"A head-to-head comparison of plasma biomarkers to detect Alzheimer's disease in a memory clinic","title_match":true,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/the-two-cut-offs-approach-for-plasma-p-tau217-in-detecting-alzheimer-40357140","doi":"10.1002/dad2.70116","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"40357140","source_url":"https://pubmed.ncbi.nlm.nih.gov/40357140/","study_design":null,"title":"The two cut-offs approach for plasma p-tau217 in detecting Alzheimer's disease in subjective cognitive decline and mild cognitive impairment","title_match":true,"year":2025},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/physical-and-biopsychosocial-frailty-cognitive-phenotypes-and-plasma-40399764","doi":"10.1002/alz.70303","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":5149,"pmid":"40399764","source_url":"https://pubmed.ncbi.nlm.nih.gov/40399764/","study_design":"cross-sectional","title":"Physical and biopsychosocial frailty, cognitive phenotypes, and plasma biomarkers for Alzheimer's disease in Chinese older adults: A population-based study","title_match":true,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/donanemab-exposure-and-efficacy-relationship-using-modeling-in-37388759","doi":"10.1002/trc2.12404","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":null,"pmid":"37388759","source_url":"https://pubmed.ncbi.nlm.nih.gov/37388759/","study_design":"clinical trial","title":"Donanemab exposure and efficacy relationship using modeling in Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/analytical-and-clinical-performance-of-eight-simoa-and-lumipulse-39702308","doi":"10.1186/s13195-024-01630-5","journal":"Alzheimer's research & therapy","n_participants":40,"pmid":"39702308","source_url":"https://pubmed.ncbi.nlm.nih.gov/39702308/","study_design":null,"title":"Analytical and clinical performance of eight Simoa\u00ae and Lumipulse\u00ae assays for automated measurement of plasma p-tau181 and p-tau217","title_match":true,"year":2024},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/comparison-of-csf-phosphorylated-tau-181-and-217-for-cognitive-decline-34310832","doi":"10.1002/alz.12415","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":753,"pmid":"34310832","source_url":"https://pubmed.ncbi.nlm.nih.gov/34310832/","study_design":null,"title":"Comparison of CSF phosphorylated tau 181 and 217 for cognitive decline","title_match":false,"year":2022},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-p-tau181-and-a42-predict-amyloid-pet-positivity-in-42163294","doi":"10.1186/s13195-026-02080-x","journal":"Alzheimer's research & therapy","n_participants":1407,"pmid":"42163294","source_url":"https://pubmed.ncbi.nlm.nih.gov/42163294/","study_design":"cohort study","title":"Plasma p-tau217, p-tau181, and A\u03b242 predict amyloid PET positivity in cognitively unimpaired adults","title_match":true,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-relationship-between-p-tau217-p-tau231-and-p-tau205-in-the-human-38391945","doi":"10.3390/cells13040331","journal":"Cells","n_participants":null,"pmid":"38391945","source_url":"https://pubmed.ncbi.nlm.nih.gov/38391945/","study_design":null,"title":"The Relationship between p-tau217, p-tau231, and p-tau205 in the Human Brain Is Affected by the Cellular Environment and Alzheimer's Disease Pathology","title_match":true,"year":2024},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/plasma-ptau-217-amyloid-1-42-ratio-for-enhanced-accuracy-and-reduced-41562409","doi":"10.1093/brain/awag001","journal":"Brain : a journal of neurology","n_participants":208,"pmid":"41562409","source_url":"https://pubmed.ncbi.nlm.nih.gov/41562409/","study_design":null,"title":"Plasma pTau 217/\u03b2-amyloid 1-42 ratio for enhanced accuracy and reduced uncertainty in detecting amyloid pathology","title_match":true,"year":2026},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-for-alzheimer-s-disease-advances-in-early-41667028","doi":"10.1016/j.arr.2026.103058","journal":"Ageing research reviews","n_participants":null,"pmid":"41667028","source_url":"https://pubmed.ncbi.nlm.nih.gov/41667028/","study_design":null,"title":"Blood-based biomarkers for Alzheimer's disease: Advances in early detection and monitoring of age-related neurodegeneration","title_match":true,"year":2026},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/cross-cohort-validation-and-cutpoint-estimation-of-the-janssen-plasma-41273220","doi":"10.1002/alz.70916","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":441,"pmid":"41273220","source_url":"https://pubmed.ncbi.nlm.nih.gov/41273220/","study_design":"cohort study","title":"Cross-cohort validation and cutpoint estimation of the Janssen plasma p-tau217+ assay in predominantly cognitively normal community studies","title_match":true,"year":2025},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/blood-based-circular-rnas-for-early-diagnosis-of-alzheimer-s-disease-42387213","doi":"10.1038/s41591-026-04485-5","journal":"Nature medicine","n_participants":551,"pmid":"42387213","source_url":"https://pubmed.ncbi.nlm.nih.gov/42387213/","study_design":null,"title":"Blood-based circular RNAs for early diagnosis of Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-217-and-amyloid-42-40-for-amyloid-risk-in-40775788","doi":"10.1186/s13195-025-01826-3","journal":"Alzheimer's research & therapy","n_participants":1545,"pmid":"40775788","source_url":"https://pubmed.ncbi.nlm.nih.gov/40775788/","study_design":null,"title":"Plasma phosphorylated tau 217 and amyloid\u2011\u03b2 42/40 for amyloid risk in subgroups","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/reversible-tau-hyperphosphorylation-in-hibernation-a-blood-biomarker-41023457","doi":"10.1007/s00401-025-02930-2","journal":"Acta neuropathologica","n_participants":null,"pmid":"41023457","source_url":"https://pubmed.ncbi.nlm.nih.gov/41023457/","study_design":null,"title":"Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study","title_match":false,"year":2025},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/apoe-4-carriership-determines-a-faster-plasma-p-tau217-progression-in-41451854","doi":"10.1002/alz.71048","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":2039,"pmid":"41451854","source_url":"https://pubmed.ncbi.nlm.nih.gov/41451854/","study_design":"longitudinal study","title":"APOE \u025b4 carriership determines a faster plasma p-tau217 progression in A\u03b2-positive individuals","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-231-increases-at-one-year-intervals-in-38489191","doi":"10.3233/jad-231479","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"38489191","source_url":"https://pubmed.ncbi.nlm.nih.gov/38489191/","study_design":null,"title":"Plasma Phosphorylated Tau 231 Increases at One-Year Intervals in Cognitively Unimpaired Subjects","title_match":false,"year":2024},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/genetic-architecture-of-plasma-ptau217-and-related-biomarkers-in-41804841","doi":"10.1002/alz.71275","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1972,"pmid":"41804841","source_url":"https://pubmed.ncbi.nlm.nih.gov/41804841/","study_design":null,"title":"Genetic architecture of plasma pTau217 and related biomarkers in Alzheimer's disease via genome-wide association studies","title_match":true,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/performance-of-plasma-p-tau217-and-nfl-in-an-unselected-memory-clinic-39583647","doi":"10.1002/dad2.70003","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"39583647","source_url":"https://pubmed.ncbi.nlm.nih.gov/39583647/","study_design":null,"title":"Performance of plasma p-tau217 and NfL in an unselected memory clinic setting","title_match":true,"year":2024},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-and-p-tau181-levels-in-well-controlled-versus-drug-41386198","doi":"10.1016/j.yebeh.2025.110855","journal":"Epilepsy & behavior : E&B","n_participants":103,"pmid":"41386198","source_url":"https://pubmed.ncbi.nlm.nih.gov/41386198/","study_design":null,"title":"Plasma p-Tau217 and p-Tau181 levels in Well-Controlled versus Drug-Resistant focal epilepsy","title_match":true,"year":2026},{"alzhub_score":84,"alzhub_url":"https://alzhub.org/study/diagnostic-performance-of-plasma-p-tau217-p-tau181-and-p-tau231-42318558","doi":"10.3389/fnagi.2026.1834591","journal":"Frontiers in aging neuroscience","n_participants":4736,"pmid":"42318558","source_url":"https://pubmed.ncbi.nlm.nih.gov/42318558/","study_design":"systematic review","title":"Diagnostic performance of plasma p-Tau217, p-Tau181, and p-Tau231 across the Alzheimer's disease continuum: a network meta-analysis","title_match":true,"year":2026},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/head-to-head-comparison-of-plasma-p-tau181-p-tau231-and-glial-37268240","doi":"10.1016/j.nbd.2023.106175","journal":"Neurobiology of disease","n_participants":88,"pmid":"37268240","source_url":"https://pubmed.ncbi.nlm.nih.gov/37268240/","study_design":null,"title":"Head-to-head comparison of plasma p-tau181, p-tau231 and glial fibrillary acidic protein in clinically unimpaired elderly with three levels of APOE4-related risk for Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/comparison-of-plasma-alzpath-p-tau217-with-lilly-p-tau217-and-p-40588775","doi":"10.1186/s40478-025-02064-2","journal":"Acta neuropathologica communications","n_participants":72,"pmid":"40588775","source_url":"https://pubmed.ncbi.nlm.nih.gov/40588775/","study_design":null,"title":"Comparison of plasma ALZpath p-Tau217 with Lilly p-Tau217 and p-Tau181 in a neuropathological cohort","title_match":true,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/diagnostic-utility-of-plasma-p-tau217-differs-by-alzheimer-s-disease-41322377","doi":"10.1002/dad2.70227","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":606,"pmid":"41322377","source_url":"https://pubmed.ncbi.nlm.nih.gov/41322377/","study_design":null,"title":"Diagnostic utility of plasma p-tau217 differs by Alzheimer's disease tau-based subtypes","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/mitochondrial-dna-affects-tau-phosphorylation-in-aging-and-alzheimer-40596736","doi":"10.1002/alz.70390","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40596736","source_url":"https://pubmed.ncbi.nlm.nih.gov/40596736/","study_design":null,"title":"Mitochondrial DNA affects tau phosphorylation in aging and Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/false-positive-plasma-p-tau217-results-associated-with-heterophilic-41457950","doi":"10.1002/alz.71045","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"41457950","source_url":"https://pubmed.ncbi.nlm.nih.gov/41457950/","study_design":null,"title":"False positive plasma p-tau217 results associated with heterophilic antibody interference: A potential clinical pitfall","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/p-tau235-a-novel-biomarker-for-staging-preclinical-alzheimer-s-disease-34725927","doi":"10.15252/emmm.202115098","journal":"EMBO molecular medicine","n_participants":null,"pmid":"34725927","source_url":"https://pubmed.ncbi.nlm.nih.gov/34725927/","study_design":null,"title":"P-tau235: a novel biomarker for staging preclinical Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/novel-plasma-biomarkers-of-amyloid-plaque-pathology-and-cortical-39989429","doi":"10.1002/alz.14535","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39989429","source_url":"https://pubmed.ncbi.nlm.nih.gov/39989429/","study_design":null,"title":"Novel plasma biomarkers of amyloid plaque pathology and cortical thickness: Evaluation of the NULISA targeted proteomic platform in an ethnically diverse cohort","title_match":true,"year":2025},{"alzhub_score":82,"alzhub_url":"https://alzhub.org/study/the-relationship-of-soluble-tau-species-with-alzheimer-s-disease-40985290","doi":"10.1002/alz.70689","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":50,"pmid":"40985290","source_url":"https://pubmed.ncbi.nlm.nih.gov/40985290/","study_design":"post-hoc analysis","title":"The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology","title_match":false,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-concordance-with-amyloid-pet-among-ethnically-diverse-39021585","doi":"10.1002/dad2.12617","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":239,"pmid":"39021585","source_url":"https://pubmed.ncbi.nlm.nih.gov/39021585/","study_design":null,"title":"Plasma p-tau217 concordance with amyloid PET among ethnically diverse older adults","title_match":true,"year":2024},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/genetic-and-environmental-contributions-to-variation-in-plasma-41231229","doi":"10.1002/alz.70906","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":6495,"pmid":"41231229","source_url":"https://pubmed.ncbi.nlm.nih.gov/41231229/","study_design":null,"title":"Genetic and environmental contributions to variation in plasma phosphorylated tau 217","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/association-between-plasma-phosphorylated-tau-217-and-cognition-in-42473272","doi":"10.1002/mds.70400","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"42473272","source_url":"https://pubmed.ncbi.nlm.nih.gov/42473272/","study_design":null,"title":"Association Between Plasma Phosphorylated Tau-217 and Cognition in Parkinson's Disease","title_match":false,"year":2026},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/clinical-performance-and-head-to-head-comparison-of-csf-p-tau235-with-36899441","doi":"10.1186/s13195-023-01201-0","journal":"Alzheimer's research & therapy","n_participants":212,"pmid":"36899441","source_url":"https://pubmed.ncbi.nlm.nih.gov/36899441/","study_design":null,"title":"Clinical performance and head-to-head comparison of CSF p-tau235 with p-tau181, p-tau217 and p-tau231 in two memory clinic cohorts","title_match":true,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-p-tau212-identifies-cognitively-unimpaired-individuals-with-41447416","doi":"10.1007/s00415-025-13572-5","journal":"Journal of neurology","n_participants":317,"pmid":"41447416","source_url":"https://pubmed.ncbi.nlm.nih.gov/41447416/","study_design":null,"title":"Plasma p-tau212 identifies cognitively unimpaired individuals with emerging amyloid-\u03b2 pathology","title_match":true,"year":2025},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/implementing-plasma-p-tau217-and-cognitive-testing-for-alzheimer-s-41804834","doi":"10.1002/alz.71251","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"41804834","source_url":"https://pubmed.ncbi.nlm.nih.gov/41804834/","study_design":"longitudinal study","title":"Implementing plasma p-tau217 and cognitive testing for Alzheimer's screening in low-education populations in central China","title_match":true,"year":2026},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-for-alzheimer-s-disease-diagnosis-a-memory-clinic-41756817","doi":"10.1002/dad2.70286","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":163,"pmid":"41756817","source_url":"https://pubmed.ncbi.nlm.nih.gov/41756817/","study_design":null,"title":"Plasma p-tau217 for Alzheimer's disease diagnosis: a memory clinic implementation approach","title_match":true,"year":2026},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/optimized-plasma-p-tau217-and-p-tau217-a42-cutoffs-enhance-detection-42619350","doi":"10.1002/alz.71763","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":191,"pmid":"42619350","source_url":"https://pubmed.ncbi.nlm.nih.gov/42619350/","study_design":null,"title":"Optimized plasma p-tau217 and p-tau217/A\u03b242 cutoffs enhance detection of pre-clinical Alzheimer's disease across diverse participants","title_match":true,"year":2026},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-improves-diagnostic-accuracy-and-clinician-confidence-42254957","doi":"10.1016/j.xinn.2026.101272","journal":"Innovation (Cambridge (Mass.))","n_participants":null,"pmid":"42254957","source_url":"https://pubmed.ncbi.nlm.nih.gov/42254957/","study_design":"cross-sectional","title":"Plasma p-Tau217 improves diagnostic accuracy and clinician confidence in cognitive disorder classification","title_match":true,"year":2026},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/csf-and-plasma-tau-biomarkers-in-the-down-syndrome-alzheimer-s-42435584","doi":"10.1016/j.ebiom.2026.106370","journal":"EBioMedicine","n_participants":461,"pmid":"42435584","source_url":"https://pubmed.ncbi.nlm.nih.gov/42435584/","study_design":"cross-sectional","title":"CSF and plasma tau biomarkers in the Down syndrome-Alzheimer's disease continuum","title_match":false,"year":2026},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/plasma-p-tau-species-are-elevated-in-presymptomatic-and-symptomatic-41539185","doi":"10.1016/j.ebiom.2026.106127","journal":"EBioMedicine","n_participants":87,"pmid":"41539185","source_url":"https://pubmed.ncbi.nlm.nih.gov/41539185/","study_design":null,"title":"Plasma p-tau species are elevated in presymptomatic and symptomatic neuronal intranuclear inclusion disease","title_match":true,"year":2026},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-217-detects-amyloid-in-neuronal-synuclein-41963316","doi":"10.1038/s41531-026-01341-8","journal":"NPJ Parkinson's disease","n_participants":253,"pmid":"41963316","source_url":"https://pubmed.ncbi.nlm.nih.gov/41963316/","study_design":null,"title":"Plasma phosphorylated tau 217 detects amyloid-\u03b2 in neuronal synuclein disease","title_match":false,"year":2026},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/tau-proteins-in-blood-as-biomarkers-of-alzheimer-s-disease-and-other-35175385","doi":"10.1007/s00702-022-02471-y","journal":"Journal of neural transmission (Vienna, Austria : 1996)","n_participants":null,"pmid":"35175385","source_url":"https://pubmed.ncbi.nlm.nih.gov/35175385/","study_design":"longitudinal study","title":"Tau proteins in blood as biomarkers of Alzheimer's disease and other proteinopathies","title_match":false,"year":2022},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/cross-sectional-and-longitudinal-diagnostic-performance-of-plasma-p-42601653","doi":"10.1002/ana.78322","journal":"Annals of neurology","n_participants":326,"pmid":"42601653","source_url":"https://pubmed.ncbi.nlm.nih.gov/42601653/","study_design":"cross-sectional","title":"Cross-Sectional and Longitudinal Diagnostic Performance of Plasma p-tau217 and p-tau217/A\u03b242 in Alzheimer's Disease","title_match":true,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/phosphorylated-tau-in-cerebrospinal-fluid-derived-extracellular-39455624","doi":"10.1038/s41598-024-75406-0","journal":"Scientific reports","n_participants":20,"pmid":"39455624","source_url":"https://pubmed.ncbi.nlm.nih.gov/39455624/","study_design":null,"title":"Phosphorylated tau in cerebrospinal fluid-derived extracellular vesicles in Alzheimer's disease: a pilot study","title_match":false,"year":2024},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/performance-of-plasma-phosphorylated-tau-217-in-patients-on-the-40725025","doi":"10.3390/ijms26146771","journal":"International journal of molecular sciences","n_participants":276,"pmid":"40725025","source_url":"https://pubmed.ncbi.nlm.nih.gov/40725025/","study_design":null,"title":"Performance of Plasma Phosphorylated tau-217 in Patients on the Continuum of Alzheimer's Disease","title_match":false,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-p-tau181-217-and-231-in-definite-creutzfeldt-38924651","doi":"10.1002/alz.13907","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":29,"pmid":"38924651","source_url":"https://pubmed.ncbi.nlm.nih.gov/38924651/","study_design":null,"title":"Cerebrospinal fluid p-tau181, 217, and 231 in definite Creutzfeldt-Jakob disease with and without concomitant pathologies","title_match":true,"year":2024},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/association-between-plasma-p-tau217-and-alzheimer-s-copathology-and-41848292","doi":"10.1002/ana.78201","journal":"Annals of neurology","n_participants":46,"pmid":"41848292","source_url":"https://pubmed.ncbi.nlm.nih.gov/41848292/","study_design":"cohort study","title":"Association between Plasma P-tau217 and Alzheimer's Copathology and Cognitive Decline in Parkinson's Disease","title_match":true,"year":2026},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/association-of-plasma-p-tau-and-p-tau-a-ratio-with-alzheimer-s-41478832","doi":"10.1016/j.tjpad.2025.100472","journal":"The journal of prevention of Alzheimer's disease","n_participants":352,"pmid":"41478832","source_url":"https://pubmed.ncbi.nlm.nih.gov/41478832/","study_design":"longitudinal study","title":"Association of plasma p-tau and p-tau/A\u03b2 ratio with Alzheimer's pathology","title_match":true,"year":2026},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/comparison-of-three-plasma-p-tau217-assays-to-detect-pet-confirmed-41788190","doi":"10.1002/dad2.70294","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":113,"pmid":"41788190","source_url":"https://pubmed.ncbi.nlm.nih.gov/41788190/","study_design":null,"title":"Comparison of three plasma p-tau217 assays to detect PET-confirmed Alzheimer's pathologies","title_match":true,"year":2026},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/brain-derived-plasma-p-tau217-shows-enhanced-dynamic-range-for-42677463","doi":"10.1002/alz.71773","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"42677463","source_url":"https://pubmed.ncbi.nlm.nih.gov/42677463/","study_design":null,"title":"Brain-derived plasma p-tau217 shows enhanced dynamic range for Alzheimer's disease neuropathological change","title_match":true,"year":2026},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau217-strongly-associates-with-memory-deficits-39879633","doi":"10.1093/brain/awaf033","journal":"Brain : a journal of neurology","n_participants":103,"pmid":"39879633","source_url":"https://pubmed.ncbi.nlm.nih.gov/39879633/","study_design":"cross-sectional","title":"Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer's disease spectrum","title_match":false,"year":2025},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/heterogeneity-in-plasma-p-tau217-response-and-its-association-with-42535277","doi":"10.1002/alz.71705","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":153,"pmid":"42535277","source_url":"https://pubmed.ncbi.nlm.nih.gov/42535277/","study_design":"longitudinal study","title":"Heterogeneity in plasma p-tau217 response and its association with cognitive trajectories under lecanemab treatment","title_match":true,"year":2026},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/multimorbidity-and-associations-with-cognition-and-alzheimer-s-42083115","doi":"10.1002/ana.78238","journal":"Annals of neurology","n_participants":3808,"pmid":"42083115","source_url":"https://pubmed.ncbi.nlm.nih.gov/42083115/","study_design":null,"title":"Multimorbidity and Associations with Cognition and Alzheimer's Disease Biomarkers","title_match":false,"year":2026},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/tailoring-thresholds-for-interpreting-plasma-p-tau217-levels-40413031","doi":"10.1136/jnnp-2025-335830","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"40413031","source_url":"https://pubmed.ncbi.nlm.nih.gov/40413031/","study_design":"cross-sectional","title":"Tailoring thresholds for interpreting plasma p-tau217 levels","title_match":true,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/combining-plasma-p-tau231-and-glial-fibrillary-acidic-protein-41065027","doi":"10.1002/alz.70796","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"41065027","source_url":"https://pubmed.ncbi.nlm.nih.gov/41065027/","study_design":null,"title":"Combining plasma p-tau231 and glial fibrillary acidic protein produces higher discriminative accuracy for amyloid positivity than other blood-based biomarker combinations","title_match":true,"year":2025},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/plasma-derived-biomarkers-of-alzheimer-s-disease-and-neuropsychiatric-37529120","doi":"10.1002/dad2.12461","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":1005,"pmid":"37529120","source_url":"https://pubmed.ncbi.nlm.nih.gov/37529120/","study_design":"cross-sectional","title":"Plasma-derived biomarkers of Alzheimer's disease and neuropsychiatric symptoms: A community-based study","title_match":false,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/a-positive-alzheimer-s-blood-biomarker-is-not-a-diagnosis-the-42866775","doi":"10.1097/ms9.0000000000005661","journal":"Annals of medicine and surgery (2012)","n_participants":null,"pmid":"42866775","source_url":"https://pubmed.ncbi.nlm.nih.gov/42866775/","study_design":null,"title":"A positive Alzheimer's blood biomarker is not a diagnosis: the presence-primacy-permission framework for plasma p-tau217","title_match":true,"year":2026},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-predicts-in-vivo-brain-pathology-and-cognition-in-36571821","doi":"10.1002/alz.12906","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":24,"pmid":"36571821","source_url":"https://pubmed.ncbi.nlm.nih.gov/36571821/","study_design":null,"title":"Plasma p-tau217 predicts in vivo brain pathology and cognition in autosomal dominant Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/neuronal-plasma-biomarkers-in-acute-ischemic-stroke-39450480","doi":"10.1177/0271678x241293537","journal":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","n_participants":193,"pmid":"39450480","source_url":"https://pubmed.ncbi.nlm.nih.gov/39450480/","study_design":null,"title":"Neuronal plasma biomarkers in acute ischemic stroke","title_match":true,"year":2025},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-and-neuropsychiatric-symptoms-in-dementia-39732510","doi":"10.1002/alz.14434","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":222,"pmid":"39732510","source_url":"https://pubmed.ncbi.nlm.nih.gov/39732510/","study_design":"longitudinal study","title":"Plasma phosphorylated tau and neuropsychiatric symptoms in dementia with Lewy bodies","title_match":false,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/refining-alzheimer-s-disease-biological-diagnosis-with-plasma-41700306","doi":"10.1002/dad2.70285","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":401,"pmid":"41700306","source_url":"https://pubmed.ncbi.nlm.nih.gov/41700306/","study_design":null,"title":"Refining Alzheimer's disease biological diagnosis with plasma biomarkers: Resolving p-tau217 \"gray zone\" with p-tau181 integration","title_match":true,"year":2026},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/racial-and-ethnic-differences-in-plasma-p-tau217-ratio-biomarker-40861822","doi":"10.1002/dad2.70164","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":6437,"pmid":"40861822","source_url":"https://pubmed.ncbi.nlm.nih.gov/40861822/","study_design":null,"title":"Racial and ethnic differences in plasma p-tau217 ratio biomarker eligibility rates in a preclinical AD trial with lecanemab","title_match":true,"year":2025},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/polygenic-scores-of-core-1-alzheimer-s-disease-biomarkers-predict-41307156","doi":"10.1002/alz.70937","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":515,"pmid":"41307156","source_url":"https://pubmed.ncbi.nlm.nih.gov/41307156/","study_design":"longitudinal study","title":"Polygenic scores of Core 1 Alzheimer's disease biomarkers predict early cognitive and pathological change","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/greater-specificity-for-cerebrospinal-fluid-p-tau231-over-p-tau181-in-26444757","doi":"10.3233/jad-150167","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"26444757","source_url":"https://pubmed.ncbi.nlm.nih.gov/26444757/","study_design":"cross-sectional","title":"Greater specificity for cerebrospinal fluid P-tau231 over P-tau181 in the differentiation of healthy controls from Alzheimer's disease","title_match":true,"year":2016},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/predictive-value-of-plasma-p-tau217-for-alzheimer-s-dementia-compared-42463545","doi":"10.1038/s44321-026-00483-9","journal":"EMBO molecular medicine","n_participants":779,"pmid":"42463545","source_url":"https://pubmed.ncbi.nlm.nih.gov/42463545/","study_design":"cohort study","title":"Predictive value of plasma p-tau217 for Alzheimer's dementia compared to other blood-based biomarkers","title_match":true,"year":2026},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-p-tau181-and-nfl-as-early-indicators-of-dementia-risk-38145191","doi":"10.1002/dad2.12514","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":1857,"pmid":"38145191","source_url":"https://pubmed.ncbi.nlm.nih.gov/38145191/","study_design":"longitudinal study","title":"Plasma p-tau217, p-tau181, and NfL as early indicators of dementia risk in a community cohort: The Shanghai Aging Study","title_match":true,"year":2023},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-predicting-brain-wide-tau-accumulation-in-preclinical-40544093","doi":"10.1016/j.tjpad.2025.100252","journal":"The journal of prevention of Alzheimer's disease","n_participants":333,"pmid":"40544093","source_url":"https://pubmed.ncbi.nlm.nih.gov/40544093/","study_design":"cross-sectional","title":"Plasma p-tau217 predicting brain-wide tau accumulation in preclinical AD","title_match":true,"year":2025},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/prognostic-value-of-plasma-p-tau217-in-cognitively-unimpaired-older-42483984","doi":"10.1002/alz.71599","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1204,"pmid":"42483984","source_url":"https://pubmed.ncbi.nlm.nih.gov/42483984/","study_design":"longitudinal study","title":"Prognostic value of plasma %p-tau217 in cognitively unimpaired older adults","title_match":true,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/locus-coeruleus-entorhinal-cortex-tract-integrity-is-linked-to-plasma-41319161","doi":"10.1002/alz.70915","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"41319161","source_url":"https://pubmed.ncbi.nlm.nih.gov/41319161/","study_design":null,"title":"Locus coeruleus-entorhinal cortex tract integrity is linked to plasma tau and glial fibrillary acidic protein","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/development-of-a-p-tau217-electrochemiluminescent-immunosensor-37939215","doi":"10.1021/acschemneuro.3c00568","journal":"ACS chemical neuroscience","n_participants":null,"pmid":"37939215","source_url":"https://pubmed.ncbi.nlm.nih.gov/37939215/","study_design":null,"title":"Development of a P-tau217 Electrochemiluminescent Immunosensor Reinforced with Au-Cu Nanoparticles for Alzheimer's Disease Precaution","title_match":true,"year":2023},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/combining-p-tau217-and-digital-cognitive-testing-to-predict-cognitive-41913058","doi":"10.1002/alz.71328","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":183,"pmid":"41913058","source_url":"https://pubmed.ncbi.nlm.nih.gov/41913058/","study_design":"longitudinal study","title":"Combining p-tau217 and digital cognitive testing to predict cognitive decline","title_match":true,"year":2026},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-and-apoe-genotype-prodromal-alzheimer-s-disease-41809502","doi":"10.1002/dad2.70279","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"41809502","source_url":"https://pubmed.ncbi.nlm.nih.gov/41809502/","study_design":null,"title":"Plasma p-tau217 and APOE genotype: Prodromal Alzheimer's disease staging","title_match":true,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/day-to-day-sleep-variability-with-alzheimer-s-biomarkers-in-at-risk-38371359","doi":"10.1002/dad2.12521","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"38371359","source_url":"https://pubmed.ncbi.nlm.nih.gov/38371359/","study_design":null,"title":"Day-to-day sleep variability with Alzheimer's biomarkers in at-risk elderly","title_match":false,"year":2024},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/physical-activity-aerobic-fitness-and-ad-blood-biomarkers-the-ignite-42151104","doi":"10.1002/alz.71484","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":648,"pmid":"42151104","source_url":"https://pubmed.ncbi.nlm.nih.gov/42151104/","study_design":null,"title":"Physical activity, aerobic fitness, and AD blood biomarkers: The IGNITE study","title_match":false,"year":2026},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/analytical-and-clinical-validation-of-the-lumipulse-g-plasma-p-tau217-41981379","doi":"10.1002/alz.71374","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"41981379","source_url":"https://pubmed.ncbi.nlm.nih.gov/41981379/","study_design":null,"title":"Analytical and clinical validation of the Lumipulse G plasma p-tau217 assay for clinical implementation","title_match":true,"year":2026},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/preclinical-dementia-rating-scores-are-associated-with-plasma-40927740","doi":"10.1002/dad2.70179","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":639,"pmid":"40927740","source_url":"https://pubmed.ncbi.nlm.nih.gov/40927740/","study_design":"longitudinal study","title":"Preclinical dementia rating scores are associated with plasma phosphorylated tau-217","title_match":false,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/plasma-p-tau212-antemortem-diagnostic-performance-and-prediction-of-38168323","doi":"10.1101/2023.12.11.23299806","journal":"Nature communications","n_participants":388,"pmid":"38168323","source_url":"https://pubmed.ncbi.nlm.nih.gov/38168323/","study_design":null,"title":"Plasma p-tau212: antemortem diagnostic performance and prediction of autopsy verification of Alzheimer's disease neuropathology","title_match":true,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-for-movement-disorders-36156206","doi":"10.1111/ane.13700","journal":"Acta neurologica Scandinavica","n_participants":null,"pmid":"36156206","source_url":"https://pubmed.ncbi.nlm.nih.gov/36156206/","study_design":"cross-sectional","title":"Blood based biomarkers for movement disorders","title_match":true,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/long-term-depression-inducing-low-frequency-stimulation-enhances-p-35871344","doi":"10.3233/jad-220351","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"35871344","source_url":"https://pubmed.ncbi.nlm.nih.gov/35871344/","study_design":null,"title":"Long-Term Depression-Inducing Low Frequency Stimulation Enhances p-Tau181 and p-Tau217 in an Age-Dependent Manner in Live Rats","title_match":true,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/clinical-validation-of-novel-immunoassays-for-plasma-phosphorylated-41321279","doi":"10.1111/jnc.70313","journal":"Journal of neurochemistry","n_participants":53,"pmid":"41321279","source_url":"https://pubmed.ncbi.nlm.nih.gov/41321279/","study_design":null,"title":"Clinical Validation of Novel Immunoassays for Plasma Phosphorylated Tau 217, 212, 181, 231, and Brain-Derived Tau Across the Biochemical Spectrum of Alzheimer's Disease","title_match":false,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/epigenetic-clocks-and-longitudinal-plasma-biomarkers-of-alzheimer-s-40832399","doi":"10.1101/2025.08.12.25333453","journal":"medRxiv : the preprint server for health sciences","n_participants":null,"pmid":"40832399","source_url":"https://pubmed.ncbi.nlm.nih.gov/40832399/","study_design":null,"title":"Epigenetic clocks and longitudinal plasma biomarkers of Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/biomarker-treatment-effects-in-two-phase-3-trials-of-gantenerumab-39887500","doi":"10.1002/alz.14414","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39887500","source_url":"https://pubmed.ncbi.nlm.nih.gov/39887500/","study_design":"clinical trial","title":"Biomarker treatment effects in two phase 3 trials of gantenerumab","title_match":false,"year":2025},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/plasma-p-tau-markers-vascular-factors-and-cognitive-decline-in-the-42273887","doi":"10.1002/alz.71588","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"42273887","source_url":"https://pubmed.ncbi.nlm.nih.gov/42273887/","study_design":"longitudinal study","title":"Plasma p-tau markers, vascular factors, and cognitive decline in the CIMA-Q cohort","title_match":true,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/machine-learning-prediction-of-tau-pet-in-alzheimer-s-disease-using-39985487","doi":"10.1002/alz.14600","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39985487","source_url":"https://pubmed.ncbi.nlm.nih.gov/39985487/","study_design":null,"title":"Machine learning prediction of tau-PET in Alzheimer's disease using plasma, MRI, and clinical data","title_match":false,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/cns-selective-plasma-p-tau217-accurately-captures-alzheimer-s-disease-42238423","doi":"10.64898/2026.05.18.26353208","journal":"medRxiv : the preprint server for health sciences","n_participants":null,"pmid":"42238423","source_url":"https://pubmed.ncbi.nlm.nih.gov/42238423/","study_design":null,"title":"CNS-selective plasma p-tau217 accurately captures Alzheimer's disease pathology and progression","title_match":true,"year":2026},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-1-40-and-postoperative-delirium-after-cardiac-surgery-42518233","doi":"10.1001/jamanetworkopen.2026.25730","journal":"JAMA network open","n_participants":null,"pmid":"42518233","source_url":"https://pubmed.ncbi.nlm.nih.gov/42518233/","study_design":"cohort study","title":"Plasma Amyloid-\u03b2 1-40 and Postoperative Delirium After Cardiac Surgery","title_match":true,"year":2026},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/plasma-p-tau231-in-the-presenilin-1-e280a-autosomal-dominant-40588692","doi":"10.1002/alz.70421","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40588692","source_url":"https://pubmed.ncbi.nlm.nih.gov/40588692/","study_design":"longitudinal study","title":"Plasma p-tau231 in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional and longitudinal cohort study","title_match":true,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/in-an-older-age-vascular-cohort-carotid-stenosis-is-associated-with-41249770","doi":"10.1002/alz.70893","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":182,"pmid":"41249770","source_url":"https://pubmed.ncbi.nlm.nih.gov/41249770/","study_design":null,"title":"In an older-age vascular cohort, carotid stenosis is associated with processing speed and executive function cognitive deficits, which correlate with p-tau217","title_match":true,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/the-performance-of-plasma-p-tau217-in-black-middle-aged-and-older-40410928","doi":"10.1002/alz.70288","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":233,"pmid":"40410928","source_url":"https://pubmed.ncbi.nlm.nih.gov/40410928/","study_design":null,"title":"The performance of plasma p-tau217 in Black middle-aged and older adults","title_match":true,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/impact-of-racialization-on-neuroimaging-and-plasma-biomarkers-of-40631440","doi":"10.1002/alz.70463","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":260,"pmid":"40631440","source_url":"https://pubmed.ncbi.nlm.nih.gov/40631440/","study_design":null,"title":"Impact of racialization on neuroimaging and plasma biomarkers of Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/optimizing-timing-and-cost-effective-use-of-plasma-biomarkers-in-40830505","doi":"10.1186/s13195-025-01851-2","journal":"Alzheimer's research & therapy","n_participants":143,"pmid":"40830505","source_url":"https://pubmed.ncbi.nlm.nih.gov/40830505/","study_design":null,"title":"Optimizing timing and cost-effective use of plasma biomarkers in Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/clinical-and-demographic-factors-modify-the-association-between-39713247","doi":"10.1002/dad2.70047","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":1185,"pmid":"39713247","source_url":"https://pubmed.ncbi.nlm.nih.gov/39713247/","study_design":null,"title":"Clinical and demographic factors modify the association between plasma phosphorylated tau-181 and cognition","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/from-amyloid-to-synaptic-dysfunction-biomarker-driven-insights-into-40864734","doi":"10.3390/cimb47080580","journal":"Current issues in molecular biology","n_participants":null,"pmid":"40864734","source_url":"https://pubmed.ncbi.nlm.nih.gov/40864734/","study_design":null,"title":"From Amyloid to Synaptic Dysfunction: Biomarker-Driven Insights into Alzheimer's Disease","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/integrating-kidney-function-assessment-into-the-clinical-40924619","doi":"10.1177/13872877251375101","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"40924619","source_url":"https://pubmed.ncbi.nlm.nih.gov/40924619/","study_design":null,"title":"Integrating kidney function assessment into the clinical interpretation of plasma Alzheimer's disease biomarkers","title_match":false,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/multicenter-validation-of-plasma-p-tau217-amyloid-beta-1-42-ratio-in-42418465","doi":"10.1002/alz.71644","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":499,"pmid":"42418465","source_url":"https://pubmed.ncbi.nlm.nih.gov/42418465/","study_design":null,"title":"Multicenter validation of plasma p-tau217/ amyloid beta 1-42 ratio in symptomatic Alzheimer's disease","title_match":true,"year":2026},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/serum-p-tau217-is-a-prognostic-indicator-of-cognitive-impairment-in-41312760","doi":"10.1002/ana.78109","journal":"Annals of neurology","n_participants":300,"pmid":"41312760","source_url":"https://pubmed.ncbi.nlm.nih.gov/41312760/","study_design":null,"title":"Serum p-tau217 Is a Prognostic Indicator of Cognitive Impairment in Idiopathic REM Sleep Behavior Disorder","title_match":true,"year":2026},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/plasma-alzheimer-s-disease-biomarker-variability-amyloid-independent-39535473","doi":"10.1002/alz.14368","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":2935,"pmid":"39535473","source_url":"https://pubmed.ncbi.nlm.nih.gov/39535473/","study_design":null,"title":"Plasma Alzheimer's disease biomarker variability: Amyloid-independent and amyloid-dependent factors","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/serum-phosphorylated-tau-217-in-gba1-variant-carriers-with-and-41569009","doi":"10.1177/1877718x251413875","journal":"Journal of Parkinson's disease","n_participants":null,"pmid":"41569009","source_url":"https://pubmed.ncbi.nlm.nih.gov/41569009/","study_design":null,"title":"Serum phosphorylated tau 217 in GBA1 variant carriers with and without Parkinson disease","title_match":false,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/tau-phosphorylation-at-alzheimer-s-disease-biomarker-sites-impairs-40469052","doi":"10.1002/alz.70320","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40469052","source_url":"https://pubmed.ncbi.nlm.nih.gov/40469052/","study_design":null,"title":"Tau phosphorylation at Alzheimer's disease biomarker sites impairs its cleavage by lysosomal proteases","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/benchmarking-of-a-multi-biomarker-low-volume-panel-for-alzheimer-s-38947090","doi":"10.1101/2024.06.13.24308895","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38947090","source_url":"https://pubmed.ncbi.nlm.nih.gov/38947090/","study_design":null,"title":"Benchmarking of a multi-biomarker low-volume panel for Alzheimer's Disease and related dementia research","title_match":false,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-of-alzheimer-s-disease-and-cognition-a-literature-38254693","doi":"10.3390/biom14010093","journal":"Biomolecules","n_participants":null,"pmid":"38254693","source_url":"https://pubmed.ncbi.nlm.nih.gov/38254693/","study_design":"longitudinal study","title":"Blood Biomarkers of Alzheimer's Disease and Cognition: A Literature Review","title_match":false,"year":2024},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-glial-fibrillary-acid-protein-and-39054505","doi":"10.1186/s13195-024-01526-4","journal":"Alzheimer's research & therapy","n_participants":76,"pmid":"39054505","source_url":"https://pubmed.ncbi.nlm.nih.gov/39054505/","study_design":"longitudinal study","title":"Plasma neurofilament light, glial fibrillary acid protein, and phosphorylated tau 181 as biomarkers for neuropsychiatric symptoms and related clinical disease progression","title_match":false,"year":2024},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/evidence-based-standardized-sample-handling-protocol-for-accurate-41025225","doi":"10.1002/alz.70752","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":15,"pmid":"41025225","source_url":"https://pubmed.ncbi.nlm.nih.gov/41025225/","study_design":null,"title":"Evidence-based standardized sample handling protocol for accurate blood-based Alzheimer's disease biomarker measurement: Results and consensus of the Global Biomarker Standardization Consortium","title_match":false,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/plasma-glial-fibrillary-acidic-protein-and-neurofilament-light-chain-34893073","doi":"10.1186/s40035-021-00275-w","journal":"Translational neurodegeneration","n_participants":211,"pmid":"34893073","source_url":"https://pubmed.ncbi.nlm.nih.gov/34893073/","study_design":"cross-sectional","title":"Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia","title_match":false,"year":2021},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/real-world-applicability-of-glial-fibrillary-acidic-protein-and-36072480","doi":"10.3389/fnagi.2022.887498","journal":"Frontiers in aging neuroscience","n_participants":63,"pmid":"36072480","source_url":"https://pubmed.ncbi.nlm.nih.gov/36072480/","study_design":"cross-sectional","title":"Real-world applicability of glial fibrillary acidic protein and neurofilament light chain in Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-and-clinical-diagnosis-in-35988220","doi":"10.3233/jad-220272","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"35988220","source_url":"https://pubmed.ncbi.nlm.nih.gov/35988220/","study_design":null,"title":"Plasma Neurofilament Light Chain and Clinical Diagnosis in Frontotemporal Dementia Syndromes","title_match":false,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-outperforms-glial-fibrillary-acidic-39577322","doi":"10.1016/j.jns.2024.123291","journal":"Journal of the neurological sciences","n_participants":22,"pmid":"39577322","source_url":"https://pubmed.ncbi.nlm.nih.gov/39577322/","study_design":null,"title":"Plasma neurofilament light outperforms glial fibrillary acidic protein in differentiating behavioural variant frontotemporal dementia from primary psychiatric disorders","title_match":false,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-and-plasma-neurofilament-light-relate-to-abnormal-31700989","doi":"10.1016/j.dadm.2019.08.008","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":333,"pmid":"31700989","source_url":"https://pubmed.ncbi.nlm.nih.gov/31700989/","study_design":null,"title":"Cerebrospinal fluid and plasma neurofilament light relate to abnormal cognition","title_match":false,"year":2019},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-and-brain-volumetric-outcomes-among-middle-37257406","doi":"10.1016/j.neurobiolaging.2023.04.013","journal":"Neurobiology of aging","n_participants":179,"pmid":"37257406","source_url":"https://pubmed.ncbi.nlm.nih.gov/37257406/","study_design":"cross-sectional","title":"Plasma neurofilament light and brain volumetric outcomes among middle-aged urban adults","title_match":false,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-reflects-more-severe-manifestation-of-40796698","doi":"10.1038/s41380-025-03149-z","journal":"Molecular psychiatry","n_participants":860,"pmid":"40796698","source_url":"https://pubmed.ncbi.nlm.nih.gov/40796698/","study_design":null,"title":"Plasma neurofilament light reflects more severe manifestation of Alzheimer's disease in men","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/traumatic-brain-injury-changes-in-plasma-amyloid-tau-and-40951938","doi":"10.1002/alz.70611","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40951938","source_url":"https://pubmed.ncbi.nlm.nih.gov/40951938/","study_design":null,"title":"Traumatic brain injury, changes in plasma amyloid, tau, and neurodegenerative biomarkers, and dementia risk","title_match":true,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/biomarkers-for-alzheimer-s-disease-are-upregulated-in-patients-with-40982223","doi":"10.1177/13872877251378759","journal":"Journal of Alzheimer's disease : JAD","n_participants":79,"pmid":"40982223","source_url":"https://pubmed.ncbi.nlm.nih.gov/40982223/","study_design":"cross-sectional","title":"Biomarkers for Alzheimer's disease are upregulated in patients with diabetic retinopathy","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/astrocyte-reactivity-is-associated-with-tau-tangle-load-and-cortical-39080744","doi":"10.1186/s13024-024-00750-8","journal":"Molecular neurodegeneration","n_participants":470,"pmid":"39080744","source_url":"https://pubmed.ncbi.nlm.nih.gov/39080744/","study_design":null,"title":"Astrocyte reactivity is associated with tau tangle load and cortical thinning in Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/pathologic-and-cognitive-correlates-of-plasma-biomarkers-in-38644682","doi":"10.1002/alz.13777","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":132,"pmid":"38644682","source_url":"https://pubmed.ncbi.nlm.nih.gov/38644682/","study_design":"longitudinal study","title":"Pathologic and cognitive correlates of plasma biomarkers in neurodegenerative disease","title_match":true,"year":2024},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/hepatic-and-renal-function-impact-concentrations-of-plasma-biomarkers-35845260","doi":"10.1002/dad2.12321","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":135,"pmid":"35845260","source_url":"https://pubmed.ncbi.nlm.nih.gov/35845260/","study_design":null,"title":"Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology","title_match":true,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-predicts-cerebellar-atrophy-and-33636389","doi":"10.1016/j.nbd.2021.105311","journal":"Neurobiology of disease","n_participants":62,"pmid":"33636389","source_url":"https://pubmed.ncbi.nlm.nih.gov/33636389/","study_design":null,"title":"Plasma neurofilament light chain predicts cerebellar atrophy and clinical progression in spinocerebellar ataxia","title_match":false,"year":2021},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/the-association-between-personality-and-plasma-biomarkers-of-37210782","doi":"10.1016/j.neurobiolaging.2023.04.011","journal":"Neurobiology of aging","n_participants":786,"pmid":"37210782","source_url":"https://pubmed.ncbi.nlm.nih.gov/37210782/","study_design":"longitudinal study","title":"The association between personality and plasma biomarkers of astrogliosis and neuronal injury","title_match":true,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/relationships-between-pet-and-blood-plasma-biomarkers-in-corticobasal-38885334","doi":"10.1002/alz.13914","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38885334","source_url":"https://pubmed.ncbi.nlm.nih.gov/38885334/","study_design":null,"title":"Relationships between PET and blood plasma biomarkers in corticobasal syndrome","title_match":true,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/serum-gfap-differentiates-alzheimer-s-disease-from-frontotemporal-35477892","doi":"10.1136/jnnp-2021-328547","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":230,"pmid":"35477892","source_url":"https://pubmed.ncbi.nlm.nih.gov/35477892/","study_design":null,"title":"Serum GFAP differentiates Alzheimer's disease from frontotemporal dementia and predicts MCI-to-dementia conversion","title_match":true,"year":2022},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/plasma-nfl-gfap-and-ptau181-in-patients-with-isolated-rem-sleep-40488440","doi":"10.1093/sleep/zsaf163","journal":"Sleep","n_participants":44,"pmid":"40488440","source_url":"https://pubmed.ncbi.nlm.nih.gov/40488440/","study_design":"cross-sectional","title":"Plasma NfL, GFAP, and pTau181 in patients with isolated REM sleep behavior disorder","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/early-alzheimer-s-disease-screening-approach-using-plasma-biomarkers-37762457","doi":"10.3390/ijms241814151","journal":"International journal of molecular sciences","n_participants":50,"pmid":"37762457","source_url":"https://pubmed.ncbi.nlm.nih.gov/37762457/","study_design":null,"title":"Early Alzheimer's Disease Screening Approach Using Plasma Biomarkers","title_match":true,"year":2023},{"alzhub_score":80,"alzhub_url":"https://alzhub.org/study/central-autonomic-network-dysfunction-and-plasma-alzheimer-s-disease-38851772","doi":"10.1186/s13195-024-01486-9","journal":"Alzheimer's research & therapy","n_participants":122,"pmid":"38851772","source_url":"https://pubmed.ncbi.nlm.nih.gov/38851772/","study_design":"meta-analysis","title":"Central autonomic network dysfunction and plasma Alzheimer's disease biomarkers in older adults","title_match":false,"year":2024},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/clinical-application-of-plasma-neurofilament-light-chain-in-a-memory-35585907","doi":"10.12779/dnd.2022.21.2.59","journal":"Dementia and neurocognitive disorders","n_participants":14,"pmid":"35585907","source_url":"https://pubmed.ncbi.nlm.nih.gov/35585907/","study_design":"longitudinal study","title":"Clinical Application of Plasma Neurofilament Light Chain in a Memory Clinic: A Pilot Study","title_match":false,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/vascular-risk-gait-behavioral-and-plasma-indicators-of-vcid-37932910","doi":"10.1002/alz.13540","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":745,"pmid":"37932910","source_url":"https://pubmed.ncbi.nlm.nih.gov/37932910/","study_design":null,"title":"Vascular risk, gait, behavioral, and plasma indicators of VCID","title_match":false,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/evaluation-of-serum-neurofilament-light-chain-and-glial-fibrillary-38352136","doi":"10.3389/fneur.2024.1320653","journal":"Frontiers in neurology","n_participants":null,"pmid":"38352136","source_url":"https://pubmed.ncbi.nlm.nih.gov/38352136/","study_design":null,"title":"Evaluation of serum neurofilament light chain and glial fibrillary acidic protein in the diagnosis of Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-neurodegenerative-biomarkers-in-cognitively-preserved-39571163","doi":"10.14336/ad.2024.1260","journal":"Aging and disease","n_participants":null,"pmid":"39571163","source_url":"https://pubmed.ncbi.nlm.nih.gov/39571163/","study_design":null,"title":"Plasma Neurodegenerative Biomarkers in Cognitively Preserved Nonagenarians","title_match":false,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/hearing-loss-plasma-neurodegenerative-biomarkers-and-cognitive-40961167","doi":"10.1177/13872877251378675","journal":"Journal of Alzheimer's disease : JAD","n_participants":373,"pmid":"40961167","source_url":"https://pubmed.ncbi.nlm.nih.gov/40961167/","study_design":"cross-sectional","title":"Hearing loss, plasma neurodegenerative biomarkers, and cognitive function: Independent and additive effects","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/preanalytical-stability-of-plasma-biomarkers-for-alzheimer-s-disease-37192842","doi":"10.1002/dad2.12439","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":13,"pmid":"37192842","source_url":"https://pubmed.ncbi.nlm.nih.gov/37192842/","study_design":null,"title":"Preanalytical stability of plasma biomarkers for Alzheimer's disease pathology","title_match":true,"year":2023},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-is-associated-with-cognitive-decline-34183688","doi":"10.1038/s41598-021-91038-0","journal":"Scientific reports","n_participants":null,"pmid":"34183688","source_url":"https://pubmed.ncbi.nlm.nih.gov/34183688/","study_design":"cross-sectional","title":"Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults","title_match":false,"year":2021},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/neuropathologic-correlates-of-distinct-plasma-biomarker-profiles-in-40465828","doi":"10.1093/brain/awaf211","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"40465828","source_url":"https://pubmed.ncbi.nlm.nih.gov/40465828/","study_design":null,"title":"Neuropathologic correlates of distinct plasma biomarker profiles in community-living older adults","title_match":true,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-protein-correlates-with-diffusion-tensor-33108404","doi":"10.1371/journal.pone.0236384","journal":"PloS one","n_participants":null,"pmid":"33108404","source_url":"https://pubmed.ncbi.nlm.nih.gov/33108404/","study_design":"longitudinal study","title":"Plasma neurofilament light protein correlates with diffusion tensor imaging metrics in frontotemporal dementia","title_match":false,"year":2020},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-nfl-and-cognitive-functioning-in-older-adults-the-moderating-41098318","doi":"10.1002/dad2.70205","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":417,"pmid":"41098318","source_url":"https://pubmed.ncbi.nlm.nih.gov/41098318/","study_design":null,"title":"Plasma NfL and cognitive functioning in older adults: The moderating role of HDL cholesterol","title_match":true,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/differential-associations-of-apoe-and-trem2-variants-with-glial-40659842","doi":"10.1038/s41380-025-03098-7","journal":"Molecular psychiatry","n_participants":50000,"pmid":"40659842","source_url":"https://pubmed.ncbi.nlm.nih.gov/40659842/","study_design":null,"title":"Differential associations of APOE and TREM2 variants with glial fibrillary acidic protein and neurofilament light in plasma of UK Biobank participants support distinct disease mechanisms","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-in-memory-clinic-practice-evidence-36462720","doi":"10.1016/j.nbd.2022.105937","journal":"Neurobiology of disease","n_participants":558,"pmid":"36462720","source_url":"https://pubmed.ncbi.nlm.nih.gov/36462720/","study_design":"cross-sectional","title":"Plasma neurofilament light chain in memory clinic practice: Evidence from a real-life study","title_match":false,"year":2023},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/white-matter-hyperintensities-in-progranulin-associated-31835286","doi":"10.1016/j.nicl.2019.102077","journal":"NeuroImage. Clinical","n_participants":336,"pmid":"31835286","source_url":"https://pubmed.ncbi.nlm.nih.gov/31835286/","study_design":"longitudinal study","title":"White matter hyperintensities in progranulin-associated frontotemporal dementia: A longitudinal GENFI study","title_match":false,"year":2019},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/reduced-plasma-a-peptides-but-stable-nfl-and-gfap-in-major-depressive-41683895","doi":"10.3390/ijms27031474","journal":"International journal of molecular sciences","n_participants":null,"pmid":"41683895","source_url":"https://pubmed.ncbi.nlm.nih.gov/41683895/","study_design":"cross-sectional","title":"Reduced Plasma A\u03b2 Peptides but Stable NfL and GFAP in Major Depressive Disorder","title_match":true,"year":2026},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/genetic-risk-and-plasma-biomarkers-of-dementia-with-lewy-bodies-in-a-40374660","doi":"10.1038/s41531-025-00988-z","journal":"NPJ Parkinson's disease","n_participants":151,"pmid":"40374660","source_url":"https://pubmed.ncbi.nlm.nih.gov/40374660/","study_design":null,"title":"Genetic risk and plasma biomarkers of dementia with Lewy bodies in a Chinese population","title_match":true,"year":2025},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/association-between-plasma-neurofilament-light-chain-levels-and-34311152","doi":"10.1016/j.jneuroim.2021.577662","journal":"Journal of neuroimmunology","n_participants":168,"pmid":"34311152","source_url":"https://pubmed.ncbi.nlm.nih.gov/34311152/","study_design":"meta-analysis","title":"Association between plasma neurofilament light chain levels and cognitive function in patients with Parkinson's disease","title_match":false,"year":2021},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/association-of-serum-neurofilament-light-chain-and-glial-fibrillary-36754139","doi":"10.1016/j.brainres.2023.148271","journal":"Brain research","n_participants":140,"pmid":"36754139","source_url":"https://pubmed.ncbi.nlm.nih.gov/36754139/","study_design":"cross-sectional","title":"Association of serum neurofilament light chain and glial fibrillary acidic protein levels with cognitive decline in Parkinson's disease","title_match":false,"year":2023},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-in-behavioural-variant-frontotemporal-37477141","doi":"10.1177/00048674231187312","journal":"The Australian and New Zealand journal of psychiatry","n_participants":42,"pmid":"37477141","source_url":"https://pubmed.ncbi.nlm.nih.gov/37477141/","study_design":null,"title":"Plasma neurofilament light in behavioural variant frontotemporal dementia compared to mood and psychotic disorders","title_match":false,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-as-a-predictor-of-multiple-system-41359208","doi":"10.1007/s00415-025-13559-2","journal":"Journal of neurology","n_participants":22,"pmid":"41359208","source_url":"https://pubmed.ncbi.nlm.nih.gov/41359208/","study_design":null,"title":"Plasma neurofilament light chain as a predictor of multiple system atrophy in idiopathic REM sleep behavior disorder","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/neuroimaging-and-biomarker-evidence-of-neurodegeneration-in-asthma-34536414","doi":"10.1016/j.jaci.2021.09.010","journal":"The Journal of allergy and clinical immunology","n_participants":111,"pmid":"34536414","source_url":"https://pubmed.ncbi.nlm.nih.gov/34536414/","study_design":null,"title":"Neuroimaging and biomarker evidence of neurodegeneration in asthma","title_match":false,"year":2022},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/type-1-diabetes-is-associated-with-higher-plasma-levels-of-biomarkers-42558640","doi":"10.3389/fimmu.2026.1860993","journal":"Frontiers in immunology","n_participants":90,"pmid":"42558640","source_url":"https://pubmed.ncbi.nlm.nih.gov/42558640/","study_design":"cross-sectional","title":"Type 1 diabetes is associated with higher plasma levels of biomarkers of neurodegeneration and neuroinflammation","title_match":false,"year":2026},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/relationship-between-plasma-neurofilament-light-chain-gut-microbiota-35180112","doi":"10.3233/jad-215141","journal":"Journal of Alzheimer's disease : JAD","n_participants":128,"pmid":"35180112","source_url":"https://pubmed.ncbi.nlm.nih.gov/35180112/","study_design":"cohort study","title":"Relationship Between Plasma Neurofilament Light Chain, Gut Microbiota, and Dementia: A Cross-Sectional Study","title_match":false,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/diagnostic-and-prognostic-value-of-plasma-neurofilament-light-and-33883011","doi":"10.1186/s13195-021-00815-6","journal":"Alzheimer's research & therapy","n_participants":70,"pmid":"33883011","source_url":"https://pubmed.ncbi.nlm.nih.gov/33883011/","study_design":null,"title":"Diagnostic and prognostic value of plasma neurofilament light and total-tau in sporadic Creutzfeldt-Jakob disease","title_match":false,"year":2021},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/alzheimer-s-and-neurodegenerative-disease-biomarkers-in-blood-predict-38689358","doi":"10.1186/s13195-024-01459-y","journal":"Alzheimer's research & therapy","n_participants":622,"pmid":"38689358","source_url":"https://pubmed.ncbi.nlm.nih.gov/38689358/","study_design":"longitudinal study","title":"Alzheimer's and neurodegenerative disease biomarkers in blood predict brain atrophy and cognitive decline","title_match":false,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-of-alzheimer-s-disease-in-the-continuum-of-dementia-38329197","doi":"10.1002/alz.13653","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38329197","source_url":"https://pubmed.ncbi.nlm.nih.gov/38329197/","study_design":null,"title":"Plasma biomarkers of Alzheimer's disease in the continuum of dementia with Lewy bodies","title_match":true,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/neurofilament-light-chain-plasma-concentration-predicts-31514172","doi":"10.18632/aging.102220","journal":"Aging","n_participants":null,"pmid":"31514172","source_url":"https://pubmed.ncbi.nlm.nih.gov/31514172/","study_design":"longitudinal study","title":"Neurofilament light chain plasma concentration predicts neurodegeneration and clinical progression in nondemented elderly adults","title_match":false,"year":2019},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/utility-of-plasma-neurofilament-light-and-total-tau-for-clinical-32995466","doi":"10.1002/dad2.12099","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"32995466","source_url":"https://pubmed.ncbi.nlm.nih.gov/32995466/","study_design":"cross-sectional","title":"Utility of plasma neurofilament light and total tau for clinical trials in Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-relationship-between-plasma-biomarkers-and-amyloid-pet-in-35872565","doi":"10.1016/j.parkreldis.2022.07.008","journal":"Parkinsonism & related disorders","n_participants":null,"pmid":"35872565","source_url":"https://pubmed.ncbi.nlm.nih.gov/35872565/","study_design":null,"title":"The relationship between plasma biomarkers and amyloid PET in dementia with Lewy bodies","title_match":true,"year":2022},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-and-longitudinal-progression-of-white-32310173","doi":"10.3233/jad-200022","journal":"Journal of Alzheimer's disease : JAD","n_participants":1029,"pmid":"32310173","source_url":"https://pubmed.ncbi.nlm.nih.gov/32310173/","study_design":"cross-sectional","title":"Plasma Neurofilament Light and Longitudinal Progression of White Matter Hyperintensity in Elderly Persons Without Dementia","title_match":false,"year":2020},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/associations-between-trajectories-of-plasma-biomarkers-for-alzheimer-40877465","doi":"10.1038/s41380-025-03166-y","journal":"Molecular psychiatry","n_participants":1270,"pmid":"40877465","source_url":"https://pubmed.ncbi.nlm.nih.gov/40877465/","study_design":"cohort study","title":"Associations between trajectories of plasma biomarkers for Alzheimer's disease, brain structures, and cognitive function: a prospective cohort study in the UK Biobank","title_match":true,"year":2026},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/a-combination-of-neurofilament-light-glial-fibrillary-acidic-protein-36120776","doi":"10.3233/jad-220318","journal":"Journal of Alzheimer's disease : JAD","n_participants":37,"pmid":"36120776","source_url":"https://pubmed.ncbi.nlm.nih.gov/36120776/","study_design":null,"title":"A Combination of Neurofilament Light, Glial Fibrillary Acidic Protein, and Neuronal Pentraxin-2 Discriminates Between Frontotemporal Dementia and Other Dementias","title_match":false,"year":2022},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/acute-effects-of-lactate-infusion-on-metabolism-ad-biomarkers-and-41376120","doi":"10.1002/alz.70984","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":24,"pmid":"41376120","source_url":"https://pubmed.ncbi.nlm.nih.gov/41376120/","study_design":null,"title":"Acute effects of lactate infusion on metabolism, AD biomarkers, and cognition: The LEAN study","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-predicts-cognitive-progression-in-34151807","doi":"10.3233/jad-210342","journal":"Journal of Alzheimer's disease : JAD","n_participants":45,"pmid":"34151807","source_url":"https://pubmed.ncbi.nlm.nih.gov/34151807/","study_design":null,"title":"Plasma Neurofilament Light Chain Predicts Cognitive Progression in Prodromal and Clinical Dementia with Lewy Bodies","title_match":false,"year":2021},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/comprehensive-cross-sectional-and-longitudinal-analyses-of-plasma-35492244","doi":"10.1016/j.xcrm.2022.100607","journal":"Cell reports. Medicine","n_participants":null,"pmid":"35492244","source_url":"https://pubmed.ncbi.nlm.nih.gov/35492244/","study_design":"longitudinal study","title":"Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-for-alzheimer-s-and-related-dementias-a-review-and-38520383","doi":"10.1093/arclin/acae019","journal":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","n_participants":null,"pmid":"38520383","source_url":"https://pubmed.ncbi.nlm.nih.gov/38520383/","study_design":null,"title":"Plasma biomarkers for Alzheimer's and related dementias: A review and outlook for clinical neuropsychology","title_match":true,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/systematic-assessment-of-10-biomarker-candidates-focusing-on-34363416","doi":"10.1002/mds.28738","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":151,"pmid":"34363416","source_url":"https://pubmed.ncbi.nlm.nih.gov/34363416/","study_design":null,"title":"Systematic Assessment of 10 Biomarker Candidates Focusing on \u03b1-Synuclein-Related Disorders","title_match":false,"year":2021},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/serum-biomarkers-associated-with-aging-and-neurodegeneration-in-38000775","doi":"10.1016/j.neulet.2023.137569","journal":"Neuroscience letters","n_participants":13,"pmid":"38000775","source_url":"https://pubmed.ncbi.nlm.nih.gov/38000775/","study_design":null,"title":"Serum biomarkers associated with aging and neurodegeneration in common marmosets (Callithrix jacchus)","title_match":true,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/association-of-plasma-biomarkers-with-amyloid-and-tau-pet-in-pre-42084083","doi":"10.1002/alz.71441","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":66,"pmid":"42084083","source_url":"https://pubmed.ncbi.nlm.nih.gov/42084083/","study_design":null,"title":"Association of plasma biomarkers with amyloid and tau PET in pre-dementia stages","title_match":true,"year":2026},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/plasma-and-mri-biomarkers-capture-neuronal-damage-in-former-40481074","doi":"10.1038/s41598-025-93066-6","journal":"Scientific reports","n_participants":15,"pmid":"40481074","source_url":"https://pubmed.ncbi.nlm.nih.gov/40481074/","study_design":"longitudinal study","title":"Plasma and MRI biomarkers capture neuronal damage in former professional boxers","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/blood-and-cerebrospinal-fluid-neurofilament-light-differentially-32810755","doi":"10.1016/j.neurobiolaging.2020.07.018","journal":"Neurobiology of aging","n_participants":227,"pmid":"32810755","source_url":"https://pubmed.ncbi.nlm.nih.gov/32810755/","study_design":null,"title":"Blood and cerebrospinal fluid neurofilament light differentially detect neurodegeneration in early Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-of-neurodegeneration-in-mild-cognitive-impairment-37489795","doi":"10.1017/s0033291723001952","journal":"Psychological medicine","n_participants":55,"pmid":"37489795","source_url":"https://pubmed.ncbi.nlm.nih.gov/37489795/","study_design":null,"title":"Plasma biomarkers of neurodegeneration in mild cognitive impairment with Lewy bodies","title_match":true,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chains-as-blood-based-biomarkers-for-early-37762074","doi":"10.3390/ijms241813771","journal":"International journal of molecular sciences","n_participants":null,"pmid":"37762074","source_url":"https://pubmed.ncbi.nlm.nih.gov/37762074/","study_design":null,"title":"Plasma Neurofilament Light Chains as Blood-Based Biomarkers for Early Diagnosis of Canine Cognitive Dysfunction Syndrome","title_match":true,"year":2023},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/distinguishing-frontotemporal-lobar-degeneration-tau-from-tdp-43-36215050","doi":"10.1001/jamaneurol.2022.3265","journal":"JAMA neurology","n_participants":46,"pmid":"36215050","source_url":"https://pubmed.ncbi.nlm.nih.gov/36215050/","study_design":"cross-sectional","title":"Distinguishing Frontotemporal Lobar Degeneration Tau From TDP-43 Using Plasma Biomarkers","title_match":true,"year":2022},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/plasma-markers-of-neurodegeneration-latent-cognitive-abilities-and-39289522","doi":"10.1038/s41598-024-72806-0","journal":"Scientific reports","n_participants":null,"pmid":"39289522","source_url":"https://pubmed.ncbi.nlm.nih.gov/39289522/","study_design":"cross-sectional","title":"Plasma markers of neurodegeneration, latent cognitive abilities and physical activity in healthy aging","title_match":false,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/peripheral-risk-factors-and-their-role-in-biomarker-based-screening-39718159","doi":"10.1002/alz.14293","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":305,"pmid":"39718159","source_url":"https://pubmed.ncbi.nlm.nih.gov/39718159/","study_design":null,"title":"Peripheral risk factors and their role in biomarker-based screening for dementia in the community","title_match":false,"year":2024},{"alzhub_score":88,"alzhub_url":"https://alzhub.org/study/alzheimer-s-blood-based-biomarkers-incident-dementia-and-interactions-42509652","doi":"10.1002/alz.71704","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":2467,"pmid":"42509652","source_url":"https://pubmed.ncbi.nlm.nih.gov/42509652/","study_design":null,"title":"Alzheimer's blood-based biomarkers, incident dementia, and interactions with age, APOE status, and hormone therapy","title_match":true,"year":2026},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/deamidation-related-blood-biomarkers-show-promise-for-early-36575499","doi":"10.1186/s40364-022-00435-8","journal":"Biomarker research","n_participants":140,"pmid":"36575499","source_url":"https://pubmed.ncbi.nlm.nih.gov/36575499/","study_design":"longitudinal study","title":"Deamidation-related blood biomarkers show promise for early diagnostics of neurodegeneration","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-may-be-a-biomarker-for-the-inverse-32082140","doi":"10.3389/fnagi.2020.00010","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"32082140","source_url":"https://pubmed.ncbi.nlm.nih.gov/32082140/","study_design":null,"title":"Plasma Neurofilament Light Chain May Be a Biomarker for the Inverse Association Between Cancers and Neurodegenerative Diseases","title_match":false,"year":2020},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/body-mass-index-and-blood-volume-influence-plasma-biomarkers-and-41074913","doi":"10.1002/alz.70765","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"41074913","source_url":"https://pubmed.ncbi.nlm.nih.gov/41074913/","study_design":null,"title":"Body mass index and blood volume influence plasma biomarkers and positron emission tomography classification in preclinical Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/novel-biomarkers-for-alzheimer-s-disease-plasma-neurofilament-light-38779175","doi":"10.1155/2024/6668159","journal":"International journal of Alzheimer's disease","n_participants":null,"pmid":"38779175","source_url":"https://pubmed.ncbi.nlm.nih.gov/38779175/","study_design":null,"title":"Novel Biomarkers for Alzheimer's Disease: Plasma Neurofilament Light and Cerebrospinal Fluid","title_match":false,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/anti-cmv-igg-seropositivity-is-associated-with-plasma-biomarker-38393897","doi":"10.3233/jad-230220","journal":"Journal of Alzheimer's disease : JAD","n_participants":303,"pmid":"38393897","source_url":"https://pubmed.ncbi.nlm.nih.gov/38393897/","study_design":"cross-sectional","title":"Anti-CMV IgG Seropositivity is Associated with Plasma Biomarker Evidence of Amyloid-\u03b2 Accumulation","title_match":true,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/correlation-studies-of-hippocampal-morphometry-and-plasma-nfl-levels-38084365","doi":"10.1109/tcss.2023.3313819","journal":"IEEE transactions on computational social systems","n_participants":null,"pmid":"38084365","source_url":"https://pubmed.ncbi.nlm.nih.gov/38084365/","study_design":null,"title":"Correlation studies of Hippocampal Morphometry and Plasma NFL Levels in Cognitively Unimpaired Subjects","title_match":true,"year":2023},{"alzhub_score":80,"alzhub_url":"https://alzhub.org/study/neurofilament-light-chain-as-a-potential-biomarker-in-plasma-for-37519166","doi":"10.31083/j.jin2204085","journal":"Journal of integrative neuroscience","n_participants":2397,"pmid":"37519166","source_url":"https://pubmed.ncbi.nlm.nih.gov/37519166/","study_design":"meta-analysis","title":"Neurofilament Light Chain as a Potential Biomarker in Plasma for Alzheimer's Disease and Mild Cognitive Impairment: A Systematic Review and a Meta-Analysis","title_match":false,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/association-of-plasma-glial-fibrillary-acidic-protein-and-42216665","doi":"10.1177/13872877261452676","journal":"Journal of Alzheimer's disease : JAD","n_participants":50,"pmid":"42216665","source_url":"https://pubmed.ncbi.nlm.nih.gov/42216665/","study_design":"cross-sectional","title":"Association of plasma glial fibrillary acidic protein and neurofilament light chain with retinal cell layer thickness: A cross-sectional study of ophthalmic surgical patients","title_match":false,"year":2026},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/atypical-white-matter-hyperintensities-markedly-impact-plasma-37393503","doi":"10.3233/jad-230315","journal":"Journal of Alzheimer's disease : JAD","n_participants":12,"pmid":"37393503","source_url":"https://pubmed.ncbi.nlm.nih.gov/37393503/","study_design":null,"title":"Atypical White Matter Hyperintensities Markedly Impact Plasma Neurofilament Light Chain Variability in GRN Patients","title_match":false,"year":2023},{"alzhub_score":80,"alzhub_url":"https://alzhub.org/study/circulating-biomarkers-of-neurodegeneration-and-all-cause-and-41824925","doi":"10.1212/wnl.0000000000214752","journal":"Neurology","n_participants":30239,"pmid":"41824925","source_url":"https://pubmed.ncbi.nlm.nih.gov/41824925/","study_design":"cohort study","title":"Circulating Biomarkers of Neurodegeneration and All-Cause and Dementia-Specific Mortality","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/biomarker-profile-of-a-chinese-als-cohort-a-comprehensive-clinical-40818509","doi":"10.1016/j.nbd.2025.107059","journal":"Neurobiology of disease","n_participants":null,"pmid":"40818509","source_url":"https://pubmed.ncbi.nlm.nih.gov/40818509/","study_design":null,"title":"Biomarker profile of a Chinese ALS cohort: A comprehensive clinical-biomarkers-imaging analysis","title_match":false,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-associated-with-impaired-regional-38425361","doi":"10.18502/cjn.v22i4.14526","journal":"Current journal of neurology","n_participants":29,"pmid":"38425361","source_url":"https://pubmed.ncbi.nlm.nih.gov/38425361/","study_design":"cross-sectional","title":"Plasma neurofilament light chain associated with impaired regional cerebral blood flow in healthy individuals","title_match":false,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-levels-correlate-with-white-matter-damage-35226303","doi":"10.1007/s40520-022-02095-y","journal":"Aging clinical and experimental research","n_participants":92,"pmid":"35226303","source_url":"https://pubmed.ncbi.nlm.nih.gov/35226303/","study_design":"cross-sectional","title":"Plasma neurofilament light levels correlate with white matter damage prior to Alzheimer's disease: results from ADNI","title_match":false,"year":2022},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/cross-sectional-and-longitudinal-evaluation-of-plasma-glial-37885919","doi":"10.1002/dad2.12492","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":567,"pmid":"37885919","source_url":"https://pubmed.ncbi.nlm.nih.gov/37885919/","study_design":"cross-sectional","title":"Cross-sectional and longitudinal evaluation of plasma glial fibrillary acidic protein to detect and predict clinical syndromes of Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-and-cognitive-decline-in-hiv-findings-from-two-u-s-41847265","doi":"10.17925/id.2025.4.1.3","journal":"TouchREVIEWS in infectious diseases","n_participants":null,"pmid":"41847265","source_url":"https://pubmed.ncbi.nlm.nih.gov/41847265/","study_design":"cross-sectional","title":"Plasma Biomarkers and Cognitive Decline in HIV: Findings from Two U.S. Cohorts","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/evaluation-of-blood-based-diagnostic-biomarkers-for-canine-cognitive-40646873","doi":"10.3390/ani15131974","journal":"Animals : an open access journal from MDPI","n_participants":null,"pmid":"40646873","source_url":"https://pubmed.ncbi.nlm.nih.gov/40646873/","study_design":null,"title":"Evaluation of Blood-Based Diagnostic Biomarkers for Canine Cognitive Dysfunction Syndrome","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-inflammasome-adaptor-protein-asc-in-plasma-as-a-biomarker-of-39063000","doi":"10.3390/ijms25147758","journal":"International journal of molecular sciences","n_participants":null,"pmid":"39063000","source_url":"https://pubmed.ncbi.nlm.nih.gov/39063000/","study_design":null,"title":"The Inflammasome Adaptor Protein ASC in Plasma as a Biomarker of Early Cognitive Changes","title_match":false,"year":2024},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/ad-related-plasma-biomarkers-in-centenarians-links-to-cognition-and-41416584","doi":"10.1002/alz.70969","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":60,"pmid":"41416584","source_url":"https://pubmed.ncbi.nlm.nih.gov/41416584/","study_design":"longitudinal study","title":"AD-related plasma biomarkers in centenarians: links to cognition and neuropathology","title_match":true,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/differential-roles-of-alzheimer-s-disease-plasma-biomarkers-in-39907189","doi":"10.1002/alz.14526","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":2984,"pmid":"39907189","source_url":"https://pubmed.ncbi.nlm.nih.gov/39907189/","study_design":null,"title":"Differential roles of Alzheimer's disease plasma biomarkers in stepwise biomarker-guided diagnostics","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-and-future-declines-in-cognition-and-34514342","doi":"10.3233/adr-210302","journal":"Journal of Alzheimer's disease reports","n_participants":null,"pmid":"34514342","source_url":"https://pubmed.ncbi.nlm.nih.gov/34514342/","study_design":null,"title":"Plasma Neurofilament Light and Future Declines in Cognition and Function in Alzheimer's Disease in the FIT-AD Trial","title_match":false,"year":2021},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/inflammation-disrupts-cognitive-integrity-via-plasma-neurofilament-35871350","doi":"10.3233/jad-220475","journal":"Journal of Alzheimer's disease : JAD","n_participants":112,"pmid":"35871350","source_url":"https://pubmed.ncbi.nlm.nih.gov/35871350/","study_design":null,"title":"Inflammation Disrupts Cognitive Integrity via Plasma Neurofilament Light Chain Coupling Brain Networks in Alzheimer's Disease","title_match":false,"year":2022},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/plasma-nfl-and-gfap-for-predicting-vci-and-related-brain-changes-in-40566826","doi":"10.1002/alz.70381","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1810,"pmid":"40566826","source_url":"https://pubmed.ncbi.nlm.nih.gov/40566826/","study_design":"longitudinal study","title":"Plasma NfL and GFAP for predicting VCI and related brain changes in community and clinical cohorts","title_match":true,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/combined-use-of-plasma-p-tau217-nfl-and-gfap-predicts-domain-specific-41319153","doi":"10.1002/alz.70934","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":523,"pmid":"41319153","source_url":"https://pubmed.ncbi.nlm.nih.gov/41319153/","study_design":null,"title":"Combined use of plasma p-tau217, NfL, and GFAP predicts domain-specific cognitive decline in cognitively unimpaired and MCI individuals","title_match":true,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-as-blood-marker-for-poor-brain-white-36371816","doi":"10.1016/j.neurobiolaging.2022.10.004","journal":"Neurobiology of aging","n_participants":163,"pmid":"36371816","source_url":"https://pubmed.ncbi.nlm.nih.gov/36371816/","study_design":null,"title":"Plasma neurofilament light as blood marker for poor brain white matter integrity among middle-aged urban adults","title_match":false,"year":2023},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/plasma-markers-of-astrocytic-and-axonal-integrity-in-idiopathic-40879604","doi":"10.1002/mds.70016","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":2004,"pmid":"40879604","source_url":"https://pubmed.ncbi.nlm.nih.gov/40879604/","study_design":"cohort study","title":"Plasma Markers of Astrocytic and Axonal Integrity in Idiopathic/Isolated REM Sleep Behavior Disorder (iRBD) as Predictors of Dementia with Lewy Bodies","title_match":false,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-as-prognostic-marker-of-cognitive-39427171","doi":"10.1186/s13195-024-01593-7","journal":"Alzheimer's research & therapy","n_participants":158,"pmid":"39427171","source_url":"https://pubmed.ncbi.nlm.nih.gov/39427171/","study_design":"cross-sectional","title":"Plasma neurofilament light chain as prognostic marker of cognitive decline in neurodegenerative diseases, a clinical setting study","title_match":false,"year":2024},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-mediates-the-effect-of-subsyndromal-40438503","doi":"10.3389/fnagi.2025.1547394","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"40438503","source_url":"https://pubmed.ncbi.nlm.nih.gov/40438503/","study_design":null,"title":"Plasma neurofilament light chain mediates the effect of subsyndromal symptomatic depression on cognitive decline in older adults","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-in-primary-progressive-aphasia-and-31640103","doi":"10.3233/jad-190838","journal":"Journal of Alzheimer's disease : JAD","n_participants":80,"pmid":"31640103","source_url":"https://pubmed.ncbi.nlm.nih.gov/31640103/","study_design":null,"title":"Plasma Neurofilament Light Chain in Primary Progressive Aphasia and Related Disorders: Clinical Significance and Metabolic Correlates","title_match":false,"year":2019},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/associations-of-plasma-neurofilament-light-chain-with-cognition-and-38664843","doi":"10.1186/s13195-024-01464-1","journal":"Alzheimer's research & therapy","n_participants":969,"pmid":"38664843","source_url":"https://pubmed.ncbi.nlm.nih.gov/38664843/","study_design":"cross-sectional","title":"Associations of plasma neurofilament light chain with cognition and neuroimaging measures in community-dwelling early old age men","title_match":false,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/heritability-of-alzheimer-s-disease-plasma-biomarkers-a-nuclear-twin-39588748","doi":"10.1002/alz.14269","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39588748","source_url":"https://pubmed.ncbi.nlm.nih.gov/39588748/","study_design":null,"title":"Heritability of Alzheimer's disease plasma biomarkers: A nuclear twin family design","title_match":true,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-diagnostic-progression-is-associated-with-41014048","doi":"10.1002/alz.70726","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":24,"pmid":"41014048","source_url":"https://pubmed.ncbi.nlm.nih.gov/41014048/","study_design":null,"title":"Alzheimer's disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome","title_match":false,"year":2025},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/presymptomatic-plasma-biomarkers-in-autosomal-dominant-alzheimer-s-42637536","doi":"10.1136/jnnp-2026-339037","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":113,"pmid":"42637536","source_url":"https://pubmed.ncbi.nlm.nih.gov/42637536/","study_design":"cohort study","title":"Presymptomatic plasma biomarkers in autosomal dominant Alzheimer's disease: sequence and timing","title_match":true,"year":2026},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/neurofilament-light-chain-and-cardiac-mibg-uptake-as-predictors-for-37233802","doi":"10.1007/s00415-023-11785-0","journal":"Journal of neurology","n_participants":null,"pmid":"37233802","source_url":"https://pubmed.ncbi.nlm.nih.gov/37233802/","study_design":null,"title":"Neurofilament light chain and cardiac MIBG uptake as predictors for phenoconversion in isolated REM sleep behavior disorder","title_match":false,"year":2023},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/association-of-cognitive-function-with-neurofilament-light-chain-in-36408096","doi":"10.3389/fnagi.2022.1027705","journal":"Frontiers in aging neuroscience","n_participants":55,"pmid":"36408096","source_url":"https://pubmed.ncbi.nlm.nih.gov/36408096/","study_design":"cohort study","title":"Association of cognitive function with Neurofilament light chain in the aqueous humor of human eye","title_match":false,"year":2022},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/inflammation-profiles-in-alzheimer-s-disease-relate-to-cognition-and-42363728","doi":"10.1002/alz.71642","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"42363728","source_url":"https://pubmed.ncbi.nlm.nih.gov/42363728/","study_design":null,"title":"Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration","title_match":false,"year":2026},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/multivariate-patterns-of-plasma-biomarkers-predict-region-specific-41830135","doi":"10.1002/alz.71265","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"41830135","source_url":"https://pubmed.ncbi.nlm.nih.gov/41830135/","study_design":null,"title":"Multivariate patterns of plasma biomarkers predict region-specific Alzheimer's pathology and cognitive decline across independent cohorts","title_match":true,"year":2026},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/association-of-csf-plasma-and-imaging-markers-of-neurodegeneration-35110378","doi":"10.1212/wnl.0000000000200035","journal":"Neurology","n_participants":401,"pmid":"35110378","source_url":"https://pubmed.ncbi.nlm.nih.gov/35110378/","study_design":"cohort study","title":"Association of CSF, Plasma, and Imaging Markers of Neurodegeneration With Clinical Progression in People With Subjective Cognitive Decline","title_match":false,"year":2022},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/plasma-biomarker-trajectories-impact-of-ad-genetic-risk-and-clinical-40151521","doi":"10.1002/dad2.70081","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"40151521","source_url":"https://pubmed.ncbi.nlm.nih.gov/40151521/","study_design":"longitudinal study","title":"Plasma biomarker trajectories: Impact of AD genetic risk and clinical progression","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/a-19-year-old-adolescent-with-probable-alzheimer-s-disease-36565128","doi":"10.3233/jad-221065","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"36565128","source_url":"https://pubmed.ncbi.nlm.nih.gov/36565128/","study_design":null,"title":"A 19-Year-Old Adolescent with Probable Alzheimer's Disease","title_match":false,"year":2023},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-ptau217-a1-42-plasma-ratio-the-first-fda-cleared-blood-biomarker-40582836","doi":"10.5582/ddt.2025.01055","journal":"Drug discoveries & therapeutics","n_participants":null,"pmid":"40582836","source_url":"https://pubmed.ncbi.nlm.nih.gov/40582836/","study_design":null,"title":"The pTau217/A\u03b21-42 plasma ratio: The first FDA-cleared blood biomarker test for diagnosis of Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-in-alzheimer-s-disease-37878665","doi":"10.1021/acschemneuro.3c00641","journal":"ACS chemical neuroscience","n_participants":null,"pmid":"37878665","source_url":"https://pubmed.ncbi.nlm.nih.gov/37878665/","study_design":null,"title":"Blood Biomarkers in Alzheimer's Disease","title_match":false,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/predicting-cognitive-decline-with-amyloid-pet-plasma-p-tau217-a42-40-41117398","doi":"10.1002/alz.70802","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":225,"pmid":"41117398","source_url":"https://pubmed.ncbi.nlm.nih.gov/41117398/","study_design":null,"title":"Predicting cognitive decline with amyloid-PET, plasma p-tau217, A\u03b242/40, and p-tau217/A\u03b242 in a community-based cohort - relevance for clinical trial enrollment","title_match":true,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/real-world-implementation-of-lecanemab-and-donanemab-in-an-italian-41857623","doi":"10.1186/s13195-026-02015-6","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"41857623","source_url":"https://pubmed.ncbi.nlm.nih.gov/41857623/","study_design":"cohort study","title":"Real-world implementation of lecanemab and donanemab in an Italian memory center: a 1-year experience","title_match":false,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/combining-lumipulse-p-tau217-and-a42-40-as-confirmatory-tests-for-a-40976838","doi":"10.1002/alz.70707","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40976838","source_url":"https://pubmed.ncbi.nlm.nih.gov/40976838/","study_design":null,"title":"Combining Lumipulse p-tau217 and A\u03b242/40 as confirmatory tests for A\u03b2 positivity prior to disease-modifying therapy","title_match":true,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-ratios-in-autosomal-dominant-alzheimer-s-disease-the-33892504","doi":"10.1093/brain/awab166","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"33892504","source_url":"https://pubmed.ncbi.nlm.nih.gov/33892504/","study_design":"cohort study","title":"Plasma amyloid-\u03b2 ratios in autosomal dominant Alzheimer's disease: the influence of genotype","title_match":true,"year":2021},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-beta-x-42-x-40-ratio-and-cognitive-decline-in-38940303","doi":"10.1002/alz.13909","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38940303","source_url":"https://pubmed.ncbi.nlm.nih.gov/38940303/","study_design":"longitudinal study","title":"Plasma amyloid beta X-42/X-40 ratio and cognitive decline in suspected early and preclinical Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/clinical-performance-and-robustness-evaluation-of-plasma-amyloid-42-36150024","doi":"10.1002/alz.12801","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"36150024","source_url":"https://pubmed.ncbi.nlm.nih.gov/36150024/","study_design":null,"title":"Clinical performance and robustness evaluation of plasma amyloid-\u03b242/40 prescreening","title_match":true,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/plasma-atn-i-classification-and-precision-pharmacology-in-alzheimer-s-37079778","doi":"10.1002/alz.13084","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37079778","source_url":"https://pubmed.ncbi.nlm.nih.gov/37079778/","study_design":null,"title":"Plasma ATN(I) classification and precision pharmacology in Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/clinical-utility-of-plasma-a42-40-ratio-by-lc-ms-ms-in-alzheimer-s-38168329","doi":"10.1101/2023.12.12.23299878","journal":"Frontiers in neurology","n_participants":null,"pmid":"38168329","source_url":"https://pubmed.ncbi.nlm.nih.gov/38168329/","study_design":null,"title":"Clinical utility of plasma A\u03b242/40 ratio by LC-MS/MS in Alzheimer's disease assessment","title_match":true,"year":2023},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/enlarged-perivascular-spaces-and-plasma-a42-a40-ratio-in-older-adults-37156179","doi":"10.1016/j.neurobiolaging.2023.04.004","journal":"Neurobiology of aging","n_participants":56,"pmid":"37156179","source_url":"https://pubmed.ncbi.nlm.nih.gov/37156179/","study_design":"longitudinal study","title":"Enlarged perivascular spaces and plasma A\u03b242/A\u03b240 ratio in older adults without dementia","title_match":true,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/diagnostic-performance-of-automated-plasma-amyloid-assays-combined-36071505","doi":"10.1186/s13195-022-01071-y","journal":"Alzheimer's research & therapy","n_participants":42,"pmid":"36071505","source_url":"https://pubmed.ncbi.nlm.nih.gov/36071505/","study_design":null,"title":"Diagnostic performance of automated plasma amyloid-\u03b2 assays combined with pre-analytical immunoprecipitation","title_match":true,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/association-of-plasma-alzheimer-s-disease-biomarkers-with-cognitive-40883967","doi":"10.1002/alz.70625","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":381,"pmid":"40883967","source_url":"https://pubmed.ncbi.nlm.nih.gov/40883967/","study_design":null,"title":"Association of plasma Alzheimer's disease biomarkers with cognitive decline in cognitively unimpaired individuals","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/is-plasma-amyloid-1-42-1-40-a-better-biomarker-for-alzheimer-s-36461122","doi":"10.1186/s12987-022-00390-4","journal":"Fluids and barriers of the CNS","n_participants":null,"pmid":"36461122","source_url":"https://pubmed.ncbi.nlm.nih.gov/36461122/","study_design":null,"title":"Is plasma amyloid-\u03b2 1-42/1-40 a better biomarker for Alzheimer's disease than A\u03b2X-42/X-40?","title_match":true,"year":2022},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/brain-amyloid-deposition-and-blood-biomarkers-in-patients-with-30958377","doi":"10.3233/jad-190056","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"30958377","source_url":"https://pubmed.ncbi.nlm.nih.gov/30958377/","study_design":null,"title":"Brain Amyloid-\u03b2 Deposition and Blood Biomarkers in Patients with Clinically Diagnosed Alzheimer's Disease","title_match":false,"year":2019},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/enhancing-diagnostic-precision-in-alzheimer-s-disease-impact-of-41326959","doi":"10.1002/alz.70931","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"41326959","source_url":"https://pubmed.ncbi.nlm.nih.gov/41326959/","study_design":null,"title":"Enhancing diagnostic precision in Alzheimer's disease: Impact of comorbidities on blood biomarkers for clinical integration","title_match":false,"year":2025},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/longitudinal-evaluation-of-the-natural-history-of-amyloid-in-plasma-32954297","doi":"10.1093/braincomms/fcaa041","journal":"Brain communications","n_participants":15,"pmid":"32954297","source_url":"https://pubmed.ncbi.nlm.nih.gov/32954297/","study_design":"longitudinal study","title":"Longitudinal evaluation of the natural history of amyloid-\u03b2 in plasma and brain","title_match":false,"year":2020},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/plasma-a42-a40-ratios-in-older-people-with-human-immunodeficiency-36610788","doi":"10.1093/cid/ciad001","journal":"Clinical infectious diseases : an official publication of the Infectious Diseases Society of America","n_participants":43,"pmid":"36610788","source_url":"https://pubmed.ncbi.nlm.nih.gov/36610788/","study_design":null,"title":"Plasma A\u03b242/A\u03b240 Ratios in Older People With Human Immunodeficiency Virus","title_match":true,"year":2023},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/cognitive-and-functional-performance-and-plasma-biomarkers-of-early-38623384","doi":"10.1002/dad2.12582","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":260,"pmid":"38623384","source_url":"https://pubmed.ncbi.nlm.nih.gov/38623384/","study_design":"cohort study","title":"Cognitive and functional performance and plasma biomarkers of early Alzheimer's disease in Down syndrome","title_match":true,"year":2024},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/diffusion-mri-relates-to-plasma-a42-40-in-pet-negative-participants-38441274","doi":"10.1002/alz.13693","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38441274","source_url":"https://pubmed.ncbi.nlm.nih.gov/38441274/","study_design":null,"title":"Diffusion MRI relates to plasma A\u03b242/40 in PET negative participants without dementia","title_match":true,"year":2024},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-biomarkers-in-the-longitudinal-early-onset-37491668","doi":"10.1002/alz.13399","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37491668","source_url":"https://pubmed.ncbi.nlm.nih.gov/37491668/","study_design":"longitudinal study","title":"Cerebrospinal fluid biomarkers in the Longitudinal Early-onset Alzheimer's Disease Study","title_match":false,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/association-of-plasma-biomarkers-of-amyloid-and-neurodegeneration-35952440","doi":"10.1016/j.neurobiolaging.2022.07.006","journal":"Neurobiology of aging","n_participants":64,"pmid":"35952440","source_url":"https://pubmed.ncbi.nlm.nih.gov/35952440/","study_design":null,"title":"Association of plasma biomarkers of amyloid and neurodegeneration with cerebrovascular disease and Alzheimer's disease","title_match":true,"year":2022},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/robustness-of-csf-a42-40-and-a42-p-tau181-measured-using-fully-36681387","doi":"10.1002/alz.12897","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":750,"pmid":"36681387","source_url":"https://pubmed.ncbi.nlm.nih.gov/36681387/","study_design":"longitudinal study","title":"Robustness of CSF A\u03b242/40 and A\u03b242/P-tau181 measured using fully automated immunoassays to detect AD-related outcomes","title_match":true,"year":2023},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/apoe-4-carrier-status-modifies-plasma-p-tau181-concentrations-in-38752508","doi":"10.1002/alz.13804","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38752508","source_url":"https://pubmed.ncbi.nlm.nih.gov/38752508/","study_design":null,"title":"APOE \u03b54 carrier status modifies plasma p-tau181 concentrations in cognitively healthy super-seniors","title_match":true,"year":2024},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/reference-intervals-for-plasma-amyloid-in-korean-adults-without-27578514","doi":"10.3343/alm.2016.36.6.595","journal":"Annals of laboratory medicine","n_participants":370,"pmid":"27578514","source_url":"https://pubmed.ncbi.nlm.nih.gov/27578514/","study_design":null,"title":"Reference Intervals for Plasma Amyloid \u03b2 in Korean Adults Without Cognitive Impairment","title_match":true,"year":2016},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/midlife-sleep-characteristics-and-alzheimer-s-disease-biomarkers-20-41981266","doi":"10.1002/alz.71342","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1325,"pmid":"41981266","source_url":"https://pubmed.ncbi.nlm.nih.gov/41981266/","study_design":null,"title":"Midlife sleep characteristics and Alzheimer's disease biomarkers 20 years later","title_match":false,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/clinical-significance-of-fluid-biomarkers-in-alzheimer-s-disease-32385624","doi":"10.1007/s43440-020-00107-0","journal":"Pharmacological reports : PR","n_participants":null,"pmid":"32385624","source_url":"https://pubmed.ncbi.nlm.nih.gov/32385624/","study_design":null,"title":"Clinical significance of fluid biomarkers in Alzheimer's Disease","title_match":false,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-importance-of-cognitive-correlates-of-plasma-amyloid-42-40-39584368","doi":"10.1177/13872877241301804","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"39584368","source_url":"https://pubmed.ncbi.nlm.nih.gov/39584368/","study_design":null,"title":"The importance of cognitive correlates of plasma amyloid-\u03b2 42/40","title_match":true,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/baseline-levels-and-longitudinal-changes-in-plasma-a42-40-among-black-38956096","doi":"10.1038/s41467-024-49859-w","journal":"Nature communications","n_participants":null,"pmid":"38956096","source_url":"https://pubmed.ncbi.nlm.nih.gov/38956096/","study_design":"longitudinal study","title":"Baseline levels and longitudinal changes in plasma A\u03b242/40 among Black and white individuals","title_match":true,"year":2024},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/choriocapillaris-reduction-accurately-discriminates-against-early-38747519","doi":"10.1002/alz.13871","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38747519","source_url":"https://pubmed.ncbi.nlm.nih.gov/38747519/","study_design":null,"title":"Choriocapillaris reduction accurately discriminates against early-onset Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/blood-essential-trace-elements-and-alzheimer-s-disease-biomarkers-in-40520530","doi":"10.3389/fnagi.2025.1539749","journal":"Frontiers in aging neuroscience","n_participants":194,"pmid":"40520530","source_url":"https://pubmed.ncbi.nlm.nih.gov/40520530/","study_design":"cross-sectional","title":"Blood essential trace elements and Alzheimer's disease biomarkers in midlife","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/plasma-a42-40-predicts-progression-from-a-amyloid-negative-to-41478830","doi":"10.1016/j.tjpad.2025.100455","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"41478830","source_url":"https://pubmed.ncbi.nlm.nih.gov/41478830/","study_design":"cohort study","title":"Plasma A\u03b242/40 predicts progression from A\u03b2-amyloid negative to positive PET scans","title_match":true,"year":2026},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-discriminate-cerebral-amyloid-status-and-cognitive-38047367","doi":"10.2174/0115672050271523231111192725","journal":"Current Alzheimer research","n_participants":null,"pmid":"38047367","source_url":"https://pubmed.ncbi.nlm.nih.gov/38047367/","study_design":"cross-sectional","title":"Blood Biomarkers Discriminate Cerebral Amyloid Status and Cognitive Diagnosis when Collected with ACD-A Anticoagulant","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-alzheimer-s-disease-biomarker-relationships-with-incident-39989078","doi":"10.1002/alz.14629","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":290,"pmid":"39989078","source_url":"https://pubmed.ncbi.nlm.nih.gov/39989078/","study_design":null,"title":"Plasma Alzheimer's disease biomarker relationships with incident abnormal amyloid PET","title_match":false,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/physical-activity-biomarkers-of-brain-pathologies-and-dementia-risk-37422285","doi":"10.1002/alz.13360","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1044,"pmid":"37422285","source_url":"https://pubmed.ncbi.nlm.nih.gov/37422285/","study_design":null,"title":"Physical activity, biomarkers of brain pathologies and dementia risk: Results from the Memento clinical cohort","title_match":false,"year":2023},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/characteristics-of-discordance-between-amyloid-positron-emission-38341444","doi":"10.1038/s41398-024-02766-6","journal":"Translational psychiatry","n_participants":null,"pmid":"38341444","source_url":"https://pubmed.ncbi.nlm.nih.gov/38341444/","study_design":"cross-sectional","title":"Characteristics of discordance between amyloid positron emission tomography and plasma amyloid-\u03b2 42/40 positivity","title_match":true,"year":2024},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/cohort-analysis-of-the-association-of-delirium-severity-with-34260706","doi":"10.1093/gerona/glab203","journal":"The journals of gerontology. Series A, Biological sciences and medical sciences","n_participants":54,"pmid":"34260706","source_url":"https://pubmed.ncbi.nlm.nih.gov/34260706/","study_design":"cohort study","title":"Cohort Analysis of the Association of Delirium Severity With Cerebrospinal Fluid Amyloid-Tau-Neurodegeneration Pathologies","title_match":false,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-and-glucose-metabolism-correlate-in-neocortical-41978790","doi":"10.1093/braincomms/fcag074","journal":"Brain communications","n_participants":null,"pmid":"41978790","source_url":"https://pubmed.ncbi.nlm.nih.gov/41978790/","study_design":null,"title":"Plasma p-tau217 and glucose metabolism correlate in neocortical association areas in Alzheimer's disease","title_match":true,"year":2026},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/performance-of-the-lumipulse-plasma-a42-40-and-ptau181-immunoassays-38304322","doi":"10.1002/dad2.12545","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":179,"pmid":"38304322","source_url":"https://pubmed.ncbi.nlm.nih.gov/38304322/","study_design":null,"title":"Performance of the Lumipulse plasma A\u03b242/40 and pTau181 immunoassays in the detection of amyloid pathology","title_match":true,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/non-linear-character-of-plasma-amyloid-beta-over-the-course-of-35401142","doi":"10.3389/fnagi.2022.832700","journal":"Frontiers in aging neuroscience","n_participants":449,"pmid":"35401142","source_url":"https://pubmed.ncbi.nlm.nih.gov/35401142/","study_design":null,"title":"Non-linear Character of Plasma Amyloid Beta Over the Course of Cognitive Decline in Alzheimer's Continuum","title_match":true,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-amyloid-beta-42-38-ratio-as-a-plasma-biomarker-of-early-memory-39241563","doi":"10.1016/j.neurobiolaging.2024.08.009","journal":"Neurobiology of aging","n_participants":null,"pmid":"39241563","source_url":"https://pubmed.ncbi.nlm.nih.gov/39241563/","study_design":null,"title":"The amyloid beta 42/38 ratio as a plasma biomarker of early memory deficits in cognitively unimpaired older adults","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-review-of-application-of-a42-40-ratio-in-diagnosis-and-prognosis-of-36155521","doi":"10.3233/jad-220673","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"36155521","source_url":"https://pubmed.ncbi.nlm.nih.gov/36155521/","study_design":null,"title":"A Review of Application of A\u03b242/40 Ratio in Diagnosis and Prognosis of Alzheimer's Disease","title_match":false,"year":2022},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/plasma-a42-40-and-cognitive-variability-are-associated-with-cognitive-37752907","doi":"10.1002/trc2.12414","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":235,"pmid":"37752907","source_url":"https://pubmed.ncbi.nlm.nih.gov/37752907/","study_design":"longitudinal study","title":"Plasma A\u03b242/40 and cognitive variability are associated with cognitive function in Black Americans: Findings from the AA-FAIM cohort","title_match":true,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-reflect-dementia-symptoms-and-are-influenced-by-40076944","doi":"10.3390/ijms26052325","journal":"International journal of molecular sciences","n_participants":111,"pmid":"40076944","source_url":"https://pubmed.ncbi.nlm.nih.gov/40076944/","study_design":null,"title":"Blood Biomarkers Reflect Dementia Symptoms and Are Influenced by Cerebrovascular Lesions","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/amyloid-beta42-plasma-levels-are-elevated-in-amnestic-mild-cognitive-19584444","doi":"10.3233/jad-2009-1144","journal":"Journal of Alzheimer's disease : JAD","n_participants":191,"pmid":"19584444","source_url":"https://pubmed.ncbi.nlm.nih.gov/19584444/","study_design":null,"title":"Amyloid-beta42 plasma levels are elevated in amnestic mild cognitive impairment","title_match":false,"year":2009},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/csf-a40-and-p-tau181-might-differentiate-atypical-from-typical-ad-36108600","doi":"10.1159/000526888","journal":"Neuro-degenerative diseases","n_participants":39,"pmid":"36108600","source_url":"https://pubmed.ncbi.nlm.nih.gov/36108600/","study_design":"retrospective cohort","title":"CSF A\u03b240 and P-Tau181 Might Differentiate Atypical from Typical AD Phenotypes: Preliminary Evidence","title_match":true,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/pre-analytical-sampling-and-storage-conditions-of-amyloid-peptides-in-33016918","doi":"10.3233/jad-200777","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"33016918","source_url":"https://pubmed.ncbi.nlm.nih.gov/33016918/","study_design":null,"title":"Pre-Analytical Sampling and Storage Conditions of Amyloid-\u03b2 Peptides in Venous and Capillary Blood","title_match":false,"year":2020},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/head-to-head-comparison-of-different-blood-collecting-tubes-for-36139033","doi":"10.3390/biom12091194","journal":"Biomolecules","n_participants":34,"pmid":"36139033","source_url":"https://pubmed.ncbi.nlm.nih.gov/36139033/","study_design":null,"title":"Head-to-Head Comparison of Different Blood Collecting Tubes for Quantification of Alzheimer's Disease Biomarkers in Plasma","title_match":false,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/vascular-risk-predicts-plasma-amyloid-42-40-through-cerebral-amyloid-37021572","doi":"10.1161/strokeaha.122.041854","journal":"Stroke","n_participants":96,"pmid":"37021572","source_url":"https://pubmed.ncbi.nlm.nih.gov/37021572/","study_design":"cross-sectional","title":"Vascular Risk Predicts Plasma Amyloid \u03b2 42/40 Through Cerebral Amyloid Burden in Apolipoprotein E \u03b54 Carriers","title_match":true,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/profiling-of-plasma-biomarkers-in-the-context-of-memory-assessment-in-37491358","doi":"10.1038/s41398-023-02558-4","journal":"Translational psychiatry","n_participants":75,"pmid":"37491358","source_url":"https://pubmed.ncbi.nlm.nih.gov/37491358/","study_design":null,"title":"Profiling of plasma biomarkers in the context of memory assessment in a tertiary memory clinic","title_match":true,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/performance-of-blood-biomarkers-in-internal-jugular-vein-for-41207832","doi":"10.1016/j.scib.2025.10.044","journal":"Science bulletin","n_participants":463,"pmid":"41207832","source_url":"https://pubmed.ncbi.nlm.nih.gov/41207832/","study_design":null,"title":"Performance of blood biomarkers in internal jugular vein for Alzheimer's disease pathologies: the Delta Method study","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/can-the-clinical-sign-head-turning-sign-and-simple-questions-in-39568089","doi":"10.1186/s13195-024-01605-6","journal":"Alzheimer's research & therapy","n_participants":155,"pmid":"39568089","source_url":"https://pubmed.ncbi.nlm.nih.gov/39568089/","study_design":null,"title":"Can the clinical sign \"head-turning sign\" and simple questions in \"Neucop-Q\" predict amyloid \u03b2 pathology?","title_match":false,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/the-association-between-plasma-amyloid-42-40-and-percentage-of-39392602","doi":"10.3233/jad-240164","journal":"Journal of Alzheimer's disease : JAD","n_participants":119,"pmid":"39392602","source_url":"https://pubmed.ncbi.nlm.nih.gov/39392602/","study_design":null,"title":"The Association Between Plasma Amyloid-\u03b2 42/40 and Percentage of Semantic Intrusion Errors in Mild Cognitive Impairment","title_match":true,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/blood-brain-barrier-dysfunction-and-a42-40-ratio-dose-dependent-37569528","doi":"10.3390/ijms241512151","journal":"International journal of molecular sciences","n_participants":172,"pmid":"37569528","source_url":"https://pubmed.ncbi.nlm.nih.gov/37569528/","study_design":null,"title":"Blood-Brain Barrier Dysfunction and A\u03b242/40 Ratio Dose-Dependent Modulation with the ApoE Genotype within the ATN Framework","title_match":false,"year":2023},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/relationship-between-physical-activity-and-biomarkers-of-pathology-39748841","doi":"10.1002/trc2.70003","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":null,"pmid":"39748841","source_url":"https://pubmed.ncbi.nlm.nih.gov/39748841/","study_design":"longitudinal study","title":"Relationship between physical activity and biomarkers of pathology and neuroinflammation in preclinical autosomal-dominant Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/interactions-between-weight-loss-and-plasma-neurodegenerative-markers-35034116","doi":"10.1093/gerona/glac015","journal":"The journals of gerontology. Series A, Biological sciences and medical sciences","n_participants":470,"pmid":"35034116","source_url":"https://pubmed.ncbi.nlm.nih.gov/35034116/","study_design":null,"title":"Interactions Between Weight Loss and Plasma Neurodegenerative Markers for Determining Cognitive Decline Among Community-Dwelling Older Adults","title_match":false,"year":2022},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/diagnostic-accuracy-of-automated-lumipulse-plasma-ptau-217-in-39174818","doi":"10.1007/s00415-024-12631-7","journal":"Journal of neurology","n_participants":98,"pmid":"39174818","source_url":"https://pubmed.ncbi.nlm.nih.gov/39174818/","study_design":"cross-sectional","title":"Diagnostic accuracy of automated Lumipulse plasma pTau-217 in Alzheimer's disease: a real-world study","title_match":true,"year":2024},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-of-neurodegeneration-and-neuroinflammation-in-42158847","doi":"10.1093/braincomms/fcag125","journal":"Brain communications","n_participants":403,"pmid":"42158847","source_url":"https://pubmed.ncbi.nlm.nih.gov/42158847/","study_design":null,"title":"Plasma biomarkers of neurodegeneration and neuroinflammation in intracranial atherosclerotic disease","title_match":true,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-of-cerebral-small-vessel-disease-38417710","doi":"10.1016/j.arr.2024.102247","journal":"Ageing research reviews","n_participants":null,"pmid":"38417710","source_url":"https://pubmed.ncbi.nlm.nih.gov/38417710/","study_design":null,"title":"Blood-based biomarkers of cerebral small vessel disease","title_match":true,"year":2024},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/plasma-tau-biomarkers-for-biological-staging-of-alzheimer-s-disease-40847200","doi":"10.1038/s43587-025-00951-w","journal":"Nature aging","n_participants":689,"pmid":"40847200","source_url":"https://pubmed.ncbi.nlm.nih.gov/40847200/","study_design":"longitudinal study","title":"Plasma tau biomarkers for biological staging of Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/a-plasma-biomarker-panel-for-detecting-early-amyloid-accumulation-and-40414160","doi":"10.1016/j.ebiom.2025.105741","journal":"EBioMedicine","n_participants":400,"pmid":"40414160","source_url":"https://pubmed.ncbi.nlm.nih.gov/40414160/","study_design":"cross-sectional","title":"A plasma biomarker panel for detecting early amyloid-\u03b2 accumulation and its changes in middle-aged cognitively unimpaired individuals at risk for Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-cyclegan-plasma-biomarker-guided-mri-to-pet-cross-modality-40822978","doi":"10.1109/isbi60581.2025.10980900","journal":"Proceedings. IEEE International Symposium on Biomedical Imaging","n_participants":null,"pmid":"40822978","source_url":"https://pubmed.ncbi.nlm.nih.gov/40822978/","study_design":null,"title":"PLASMA-CYCLEGAN: PLASMA BIOMARKER-GUIDED MRI TO PET CROSS-MODALITY TRANSLATION USING CONDITIONAL CYCLEGAN","title_match":true,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/evaluation-of-plasma-p-tau217-biomarkers-in-detecting-amyloid-41653881","doi":"10.1016/j.tjpad.2026.100502","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"41653881","source_url":"https://pubmed.ncbi.nlm.nih.gov/41653881/","study_design":"longitudinal study","title":"Evaluation of plasma p-tau217 biomarkers in detecting amyloid pathology and predicting cognitive outcomes: Observations from Japanese Alzheimer's disease neuroimaging initiative cohort","title_match":true,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/blood-biomarker-based-classification-study-for-neurodegenerative-37821485","doi":"10.1038/s41598-023-43956-4","journal":"Scientific reports","n_participants":null,"pmid":"37821485","source_url":"https://pubmed.ncbi.nlm.nih.gov/37821485/","study_design":null,"title":"Blood biomarker-based classification study for neurodegenerative diseases","title_match":false,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/a-possible-blood-plasma-biomarker-for-early-stage-alzheimer-s-disease-35446894","doi":"10.1371/journal.pone.0267407","journal":"PloS one","n_participants":25,"pmid":"35446894","source_url":"https://pubmed.ncbi.nlm.nih.gov/35446894/","study_design":null,"title":"A possible blood plasma biomarker for early-stage Alzheimer's disease","title_match":true,"year":2022},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/unexpected-low-rate-of-amyloid-pathology-in-multiple-sclerosis-38963256","doi":"10.1002/ana.27027","journal":"Annals of neurology","n_participants":null,"pmid":"38963256","source_url":"https://pubmed.ncbi.nlm.nih.gov/38963256/","study_design":null,"title":"Unexpected Low Rate of Amyloid-\u03b2 Pathology in Multiple Sclerosis Patients","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/relationship-between-dementia-and-systemic-metabolic-disorders-39400834","doi":"10.1007/978-3-031-67458-7_44","journal":"Advances in experimental medicine and biology","n_participants":null,"pmid":"39400834","source_url":"https://pubmed.ncbi.nlm.nih.gov/39400834/","study_design":null,"title":"Relationship Between Dementia and Systemic Metabolic Disorders","title_match":false,"year":2024},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/plasma-biomarker-trajectories-across-alzheimer-s-clinical-onset-a-17-42021299","doi":"10.1186/s13195-026-02045-0","journal":"Alzheimer's research & therapy","n_participants":17,"pmid":"42021299","source_url":"https://pubmed.ncbi.nlm.nih.gov/42021299/","study_design":"longitudinal study","title":"Plasma biomarker trajectories across Alzheimer's clinical onset: a 17-year prospective study","title_match":true,"year":2026},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-of-neurodegeneration-in-patients-and-high-risk-39085262","doi":"10.1038/s41531-024-00745-8","journal":"NPJ Parkinson's disease","n_participants":84,"pmid":"39085262","source_url":"https://pubmed.ncbi.nlm.nih.gov/39085262/","study_design":null,"title":"Plasma biomarkers of neurodegeneration in patients and high risk subjects with Lewy body disease","title_match":true,"year":2024},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/diagnostic-accuracy-of-blood-based-biomarker-panels-a-systematic-35360215","doi":"10.3389/fnagi.2022.683689","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"35360215","source_url":"https://pubmed.ncbi.nlm.nih.gov/35360215/","study_design":"systematic review","title":"Diagnostic Accuracy of Blood-Based Biomarker Panels: A Systematic Review","title_match":true,"year":2022},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/effects-of-obesity-on-plasma-biomarker-and-amyloid-pet-trajectories-40620424","doi":"10.1002/dad2.70143","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"40620424","source_url":"https://pubmed.ncbi.nlm.nih.gov/40620424/","study_design":"cross-sectional","title":"Effects of obesity on plasma biomarker and amyloid PET trajectories in Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/mitochondrial-blood-based-biomarker-is-related-to-cardiorespiratory-41070365","doi":"10.1002/trc2.70163","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":null,"pmid":"41070365","source_url":"https://pubmed.ncbi.nlm.nih.gov/41070365/","study_design":null,"title":"Mitochondrial blood-based biomarker is related to cardiorespiratory fitness and aging in a sex-dependent manner","title_match":true,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-in-alzheimer-s-disease-future-directions-for-38058357","doi":"10.1002/dad2.12508","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"38058357","source_url":"https://pubmed.ncbi.nlm.nih.gov/38058357/","study_design":null,"title":"Blood-based biomarkers in Alzheimer's disease: Future directions for implementation","title_match":true,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/a-blood-test-for-alzheimer-s-disease-progress-challenges-and-29614671","doi":"10.3233/jad-179904","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"29614671","source_url":"https://pubmed.ncbi.nlm.nih.gov/29614671/","study_design":null,"title":"A Blood Test for Alzheimer's Disease: Progress, Challenges, and Recommendations","title_match":true,"year":2018},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/caregivers-attitudes-toward-blood-based-biomarker-testing-for-38371360","doi":"10.1002/dad2.12549","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":107,"pmid":"38371360","source_url":"https://pubmed.ncbi.nlm.nih.gov/38371360/","study_design":null,"title":"Caregivers' attitudes toward blood-based biomarker testing for Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/acceptability-and-feasibility-of-plasma-phosphorylated-tau181-in-two-36852663","doi":"10.1002/gps.5897","journal":"International journal of geriatric psychiatry","n_participants":null,"pmid":"36852663","source_url":"https://pubmed.ncbi.nlm.nih.gov/36852663/","study_design":null,"title":"Acceptability and feasibility of plasma phosphorylated-tau181 in two memory services","title_match":false,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-and-alzheimer-s-disease-related-changes-in-late-life-28453490","doi":"10.3233/jad-170111","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"28453490","source_url":"https://pubmed.ncbi.nlm.nih.gov/28453490/","study_design":null,"title":"Plasma Amyloid-\u03b2 and Alzheimer's Disease-Related Changes in Late-Life Depression","title_match":true,"year":2017},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/multivariate-models-using-nulisaseq-and-plasma-p-tau217-for-staging-41133401","doi":"10.1002/alz.70793","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":387,"pmid":"41133401","source_url":"https://pubmed.ncbi.nlm.nih.gov/41133401/","study_design":null,"title":"Multivariate models using NULISAseq and plasma p-tau217 for staging Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/considerations-for-use-of-blood-based-biomarkers-in-epidemiologic-37846130","doi":"10.1093/aje/kwad197","journal":"American journal of epidemiology","n_participants":null,"pmid":"37846130","source_url":"https://pubmed.ncbi.nlm.nih.gov/37846130/","study_design":null,"title":"Considerations for Use of Blood-Based Biomarkers in Epidemiologic Dementia Research","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/potential-of-hsa-mir200a-3p-and-hsa-mir502-3p-as-blood-based-36251230","doi":"10.1007/s11033-022-07987-w","journal":"Molecular biology reports","n_participants":null,"pmid":"36251230","source_url":"https://pubmed.ncbi.nlm.nih.gov/36251230/","study_design":null,"title":"Potential of hsa-miR200a-3p and hsa-miR502-3p as blood-based biomarker for Alzheimer's disease","title_match":true,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/blood-based-systems-biology-biomarkers-for-next-generation-clinical-31636492","doi":"10.31887/dcns.2019.21.2/hhampel","journal":"Dialogues in clinical neuroscience","n_participants":null,"pmid":"31636492","source_url":"https://pubmed.ncbi.nlm.nih.gov/31636492/","study_design":null,"title":"Blood-based systems biology biomarkers for next-generation clinical trials in Alzheimer's disease ","title_match":false,"year":2019},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-nt1-tau-is-a-specific-and-early-marker-of-alzheimer-s-disease-32829532","doi":"10.1002/ana.25885","journal":"Annals of neurology","n_participants":null,"pmid":"32829532","source_url":"https://pubmed.ncbi.nlm.nih.gov/32829532/","study_design":null,"title":"Plasma NT1 Tau is a Specific and Early Marker of Alzheimer's Disease","title_match":false,"year":2020},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-and-plasma-a-assays-in-the-differential-39736793","doi":"10.1186/s13195-024-01647-w","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"39736793","source_url":"https://pubmed.ncbi.nlm.nih.gov/39736793/","study_design":null,"title":"Blood-based biomarkers and plasma A\u03b2 assays in the differential diagnosis of Alzheimer's disease and behavioral-variant frontotemporal dementia","title_match":true,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/enhancing-dementia-risk-screening-with-gan-synthesized-periodontal-39206296","doi":"10.3389/fneur.2024.1379916","journal":"Frontiers in neurology","n_participants":108,"pmid":"39206296","source_url":"https://pubmed.ncbi.nlm.nih.gov/39206296/","study_design":null,"title":"Enhancing dementia risk screening with GAN-synthesized periodontal examination and general blood test data","title_match":true,"year":2024},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-and-their-correlation-in-adult-children-of-parents-36110426","doi":"10.3389/fnagi.2022.977515","journal":"Frontiers in aging neuroscience","n_participants":99,"pmid":"36110426","source_url":"https://pubmed.ncbi.nlm.nih.gov/36110426/","study_design":"longitudinal study","title":"Plasma biomarkers and their correlation in adult children of parents with Alzheimer's disease","title_match":true,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/associations-of-alzheimer-s-related-plasma-biomarkers-with-cognitive-37480401","doi":"10.1007/s00415-023-11875-z","journal":"Journal of neurology","n_participants":null,"pmid":"37480401","source_url":"https://pubmed.ncbi.nlm.nih.gov/37480401/","study_design":null,"title":"Associations of Alzheimer's-related plasma biomarkers with cognitive decline in Parkinson's disease","title_match":true,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/blood-tests-for-alzheimer-s-disease-increasing-efforts-to-expand-and-35491788","doi":"10.3233/jad-215730","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"35491788","source_url":"https://pubmed.ncbi.nlm.nih.gov/35491788/","study_design":null,"title":"Blood Tests for Alzheimer's Disease: Increasing Efforts to Expand and Diversify Research Participation Is Critical for Widespread Validation and Acceptance","title_match":true,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/early-diagnosis-of-alzheimer-s-disease-with-blood-test-tempting-but-38313372","doi":"10.22088/ijmcm.bums.12.2.172","journal":"International journal of molecular and cellular medicine","n_participants":null,"pmid":"38313372","source_url":"https://pubmed.ncbi.nlm.nih.gov/38313372/","study_design":null,"title":"Early Diagnosis of Alzheimer's Disease with Blood Test; Tempting but Challenging","title_match":true,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/amyloid-metabolism-and-amyloid-targeting-blood-based-biomarkers-of-32390633","doi":"10.3233/jad-200104","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"32390633","source_url":"https://pubmed.ncbi.nlm.nih.gov/32390633/","study_design":null,"title":"Amyloid Metabolism and Amyloid-Targeting Blood-Based Biomarkers of Alzheimer's Disease","title_match":true,"year":2020},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/a-blood-biomarker-test-for-brain-amyloid-impacts-the-clinical-37550958","doi":"10.1002/acn3.51863","journal":"Annals of clinical and translational neurology","n_participants":366,"pmid":"37550958","source_url":"https://pubmed.ncbi.nlm.nih.gov/37550958/","study_design":"cohort study","title":"A blood biomarker test for brain amyloid impacts the clinical evaluation of cognitive impairment","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-blood-test-for-alzheimer-s-disease-it-s-about-time-or-not-ready-for-35147543","doi":"10.3233/jad-215490","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"35147543","source_url":"https://pubmed.ncbi.nlm.nih.gov/35147543/","study_design":null,"title":"A Blood Test for Alzheimer's Disease: It's about Time or Not Ready for Prime Time?","title_match":true,"year":2022},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/a-novel-plasma-based-biomarker-of-alzheimer-s-disease-26401710","doi":"10.3233/jad-150183","journal":"Journal of Alzheimer's disease : JAD","n_participants":135,"pmid":"26401710","source_url":"https://pubmed.ncbi.nlm.nih.gov/26401710/","study_design":null,"title":"A Novel Plasma Based Biomarker of Alzheimer's Disease","title_match":false,"year":2015},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/blood-neurofilament-levels-predict-cognitive-decline-across-the-38139190","doi":"10.3390/ijms242417361","journal":"International journal of molecular sciences","n_participants":350,"pmid":"38139190","source_url":"https://pubmed.ncbi.nlm.nih.gov/38139190/","study_design":null,"title":"Blood Neurofilament Levels Predict Cognitive Decline across the Alzheimer's Disease Continuum","title_match":false,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/highly-sensitive-blood-based-biomarkers-detection-of-beta-amyloid-and-39286809","doi":"10.3389/fneur.2024.1445479","journal":"Frontiers in neurology","n_participants":null,"pmid":"39286809","source_url":"https://pubmed.ncbi.nlm.nih.gov/39286809/","study_design":null,"title":"Highly sensitive blood-based biomarkers detection of beta-amyloid and phosphorylated-tau181 for Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/biological-age-acceleration-associates-with-alzheimer-s-disease-41572665","doi":"10.1002/alz.71005","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"41572665","source_url":"https://pubmed.ncbi.nlm.nih.gov/41572665/","study_design":null,"title":"Biological age acceleration associates with Alzheimer's disease plasma biomarker levels","title_match":true,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/high-performance-plasma-biomarker-panel-for-alzheimer-s-disease-38117205","doi":"10.1021/acsnano.3c09311","journal":"ACS nano","n_participants":null,"pmid":"38117205","source_url":"https://pubmed.ncbi.nlm.nih.gov/38117205/","study_design":null,"title":"High-Performance Plasma Biomarker Panel for Alzheimer's Disease Screening Using a Femtomolar-Level Label-Free Biosensing System","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/fibrinogen-isoforms-as-potential-blood-based-biomarkers-of-alzheimer-33280461","doi":"10.1080/00207454.2020.1860038","journal":"The International journal of neuroscience","n_participants":null,"pmid":"33280461","source_url":"https://pubmed.ncbi.nlm.nih.gov/33280461/","study_design":null,"title":"Fibrinogen isoforms as potential blood-based biomarkers of Alzheimer's disease using a proteomics approach","title_match":true,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-p-tau181-associated-with-structural-changes-in-mild-cognitive-35648357","doi":"10.1007/s40520-022-02148-2","journal":"Aging clinical and experimental research","n_participants":null,"pmid":"35648357","source_url":"https://pubmed.ncbi.nlm.nih.gov/35648357/","study_design":"cross-sectional","title":"Plasma p-tau181 associated with structural changes in mild cognitive impairment","title_match":true,"year":2022},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/design-and-feasibility-of-an-alzheimer-s-disease-blood-test-study-in-37204806","doi":"10.1002/alz.13125","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":859,"pmid":"37204806","source_url":"https://pubmed.ncbi.nlm.nih.gov/37204806/","study_design":null,"title":"Design and feasibility of an Alzheimer's disease blood test study in a diverse community-based population","title_match":true,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/adam10-biomarker-of-mild-cognitive-impairment-but-not-of-cognitive-33675901","doi":"10.1016/j.exger.2021.111303","journal":"Experimental gerontology","n_participants":null,"pmid":"33675901","source_url":"https://pubmed.ncbi.nlm.nih.gov/33675901/","study_design":null,"title":"ADAM10: Biomarker of mild cognitive impairment but not of cognitive frailty","title_match":false,"year":2021},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/fluid-candidate-biomarkers-for-alzheimer-s-disease-a-precision-33187336","doi":"10.3390/jpm10040221","journal":"Journal of personalized medicine","n_participants":null,"pmid":"33187336","source_url":"https://pubmed.ncbi.nlm.nih.gov/33187336/","study_design":null,"title":"Fluid Candidate Biomarkers for Alzheimer's Disease: A Precision Medicine Approach","title_match":false,"year":2020},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-for-alzheimer-s-disease-a-multicenter-based-37500404","doi":"10.1016/j.scib.2023.07.009","journal":"Science bulletin","n_participants":null,"pmid":"37500404","source_url":"https://pubmed.ncbi.nlm.nih.gov/37500404/","study_design":"cross-sectional","title":"Blood-based biomarkers for Alzheimer's disease: a multicenter-based cross-sectional and longitudinal study in China","title_match":true,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/editorial-introduction-to-the-special-issue-on-biomarker-based-40266020","doi":"10.1111/jnp.12427","journal":"Journal of neuropsychology","n_participants":null,"pmid":"40266020","source_url":"https://pubmed.ncbi.nlm.nih.gov/40266020/","study_design":null,"title":"Editorial introduction to the special issue on biomarker-based diagnosis of Alzheimer's disease: A synthesis of the commentaries","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/a-genome-wide-association-study-of-plasma-phosphorylated-tau181-34119372","doi":"10.1016/j.neurobiolaging.2021.04.018","journal":"Neurobiology of aging","n_participants":1153,"pmid":"34119372","source_url":"https://pubmed.ncbi.nlm.nih.gov/34119372/","study_design":null,"title":"A genome-wide association study of plasma phosphorylated tau181","title_match":false,"year":2021},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/deep-learning-based-screening-test-for-cognitive-impairment-using-33381075","doi":"10.3389/fneur.2020.588140","journal":"Frontiers in neurology","n_participants":202,"pmid":"33381075","source_url":"https://pubmed.ncbi.nlm.nih.gov/33381075/","study_design":null,"title":"Deep Learning-Based Screening Test for Cognitive Impairment Using Basic Blood Test Data for Health Examination","title_match":true,"year":2020},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/a-fragment-of-s38aa-is-a-novel-plasma-biomarker-of-alzheimer-s-disease-31524172","doi":"10.3233/jad-190700","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"31524172","source_url":"https://pubmed.ncbi.nlm.nih.gov/31524172/","study_design":null,"title":"A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer's Disease","title_match":true,"year":2019},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/elevation-of-plasma-phosphorylated-tau181-during-neurological-36204656","doi":"10.1002/dad2.12358","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"36204656","source_url":"https://pubmed.ncbi.nlm.nih.gov/36204656/","study_design":null,"title":"Elevation of plasma phosphorylated tau181 during neurological illnesses affecting consciousness and kidney dysfunction","title_match":false,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/microrna-predicts-cognitive-performance-in-healthy-older-adults-32846274","doi":"10.1016/j.neurobiolaging.2020.07.023","journal":"Neurobiology of aging","n_participants":null,"pmid":"32846274","source_url":"https://pubmed.ncbi.nlm.nih.gov/32846274/","study_design":null,"title":"MicroRNA predicts cognitive performance in healthy older adults","title_match":false,"year":2020},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/plasma-a-biomarker-for-early-diagnosis-and-prognosis-of-alzheimer-s-37341353","doi":null,"journal":"Danish medical journal","n_participants":17,"pmid":"37341353","source_url":"https://pubmed.ncbi.nlm.nih.gov/37341353/","study_design":"systematic review","title":"Plasma A\u03b2 biomarker for early diagnosis and prognosis of Alzheimer's disease - a systematic review","title_match":true,"year":2023},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/cerebrovascular-disease-is-associated-with-alzheimer-s-plasma-39403075","doi":"10.1093/braincomms/fcae331","journal":"Brain communications","n_participants":null,"pmid":"39403075","source_url":"https://pubmed.ncbi.nlm.nih.gov/39403075/","study_design":"cross-sectional","title":"Cerebrovascular disease is associated with Alzheimer's plasma biomarker concentrations in adults with Down syndrome","title_match":true,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-for-predicting-the-development-of-dementia-in-a-38606661","doi":"10.1111/pcn.13661","journal":"Psychiatry and clinical neurosciences","n_participants":151,"pmid":"38606661","source_url":"https://pubmed.ncbi.nlm.nih.gov/38606661/","study_design":null,"title":"Plasma biomarkers for predicting the development of dementia in a community-dwelling older Japanese population","title_match":true,"year":2024},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/plasma-glial-fibrillary-acidic-protein-in-the-visual-and-language-38528318","doi":"10.1002/alz.13713","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38528318","source_url":"https://pubmed.ncbi.nlm.nih.gov/38528318/","study_design":null,"title":"Plasma glial fibrillary acidic protein in the visual and language variants of Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/symptom-guided-blood-biomarker-testing-for-alzheimer-s-disease-42862762","doi":"10.1159/dem/aciag010","journal":"Dementia and geriatric cognitive disorders","n_participants":603,"pmid":"42862762","source_url":"https://pubmed.ncbi.nlm.nih.gov/42862762/","study_design":null,"title":"Symptom-Guided Blood Biomarker Testing for Alzheimer's Disease","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/multimer-detection-system-oligomerized-amyloid-beta-mds-oa-a-plasma-35547155","doi":"10.1155/2022/9960832","journal":"International journal of Alzheimer's disease","n_participants":null,"pmid":"35547155","source_url":"https://pubmed.ncbi.nlm.nih.gov/35547155/","study_design":null,"title":"Multimer Detection System-Oligomerized Amyloid Beta (MDS-OA\u03b2): A Plasma-Based Biomarker Differentiates Alzheimer's Disease from Other Etiologies of Dementia","title_match":false,"year":2022},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/biological-age-and-age-acceleration-predict-alzheimer-s-disease-40661306","doi":"10.1101/2025.05.22.25328181","journal":"medRxiv : the preprint server for health sciences","n_participants":null,"pmid":"40661306","source_url":"https://pubmed.ncbi.nlm.nih.gov/40661306/","study_design":null,"title":"Biological Age and Age Acceleration Predict Alzheimer's Disease Plasma Biomarker Levels","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/lifestyle-factors-and-plasma-biomarkers-of-alzheimer-s-disease-a-40082178","doi":"10.1016/j.tjpad.2025.100130","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"40082178","source_url":"https://pubmed.ncbi.nlm.nih.gov/40082178/","study_design":null,"title":"Lifestyle factors and plasma biomarkers of Alzheimer's disease: A narrative review","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-of-alzheimer-s-disease-balancing-clinical-relevance-41194436","doi":"10.17219/acem/208917","journal":"Advances in clinical and experimental medicine : official organ Wroclaw Medical University","n_participants":null,"pmid":"41194436","source_url":"https://pubmed.ncbi.nlm.nih.gov/41194436/","study_design":null,"title":"Blood biomarkers of Alzheimer's disease: Balancing clinical relevance with improved accessibility and sustainability","title_match":false,"year":2025},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/the-panama-aging-research-initiative-longitudinal-study-31401637","doi":"10.37757/mr2019.v21.n2-3.10","journal":"MEDICC review","n_participants":423,"pmid":"31401637","source_url":"https://pubmed.ncbi.nlm.nih.gov/31401637/","study_design":"cohort study","title":"The Panama Aging Research Initiative Longitudinal Study","title_match":false,"year":2019},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/evaluation-of-blood-based-plasma-biomarkers-as-potential-markers-of-36710683","doi":"10.3233/jad-221118","journal":"Journal of Alzheimer's disease : JAD","n_participants":100,"pmid":"36710683","source_url":"https://pubmed.ncbi.nlm.nih.gov/36710683/","study_design":"cross-sectional","title":"Evaluation of Blood-Based Plasma Biomarkers as Potential Markers of Amyloid Burden in Preclinical Alzheimer's Disease","title_match":true,"year":2023},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/resting-state-eeg-captures-functional-network-correlates-of-plasma-p-41534360","doi":"10.1016/j.nicl.2026.103947","journal":"NeuroImage. Clinical","n_participants":128,"pmid":"41534360","source_url":"https://pubmed.ncbi.nlm.nih.gov/41534360/","study_design":null,"title":"Resting-State EEG captures functional network correlates of plasma p-Tau-217 in Alzheimer's disease","title_match":true,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/developing-educational-materials-to-aid-in-alzheimer-s-blood-41262682","doi":"10.1002/trc2.70182","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":null,"pmid":"41262682","source_url":"https://pubmed.ncbi.nlm.nih.gov/41262682/","study_design":null,"title":"Developing educational materials to aid in Alzheimer's blood biomarker disclosure","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/plasma-total-tau-and-neurobehavioral-symptoms-of-cognitive-decline-in-34803857","doi":"10.3389/fpsyg.2021.774049","journal":"Frontiers in psychology","n_participants":null,"pmid":"34803857","source_url":"https://pubmed.ncbi.nlm.nih.gov/34803857/","study_design":"longitudinal study","title":"Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-for-dementia-with-lewy-bodies-42261703","doi":"10.1177/13872877261456317","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"42261703","source_url":"https://pubmed.ncbi.nlm.nih.gov/42261703/","study_design":null,"title":"Blood-based biomarkers for dementia with Lewy bodies","title_match":true,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/integration-of-amyloid-oligomerization-tendency-as-a-plasma-biomarker-36733444","doi":"10.3389/fneur.2022.1028448","journal":"Frontiers in neurology","n_participants":null,"pmid":"36733444","source_url":"https://pubmed.ncbi.nlm.nih.gov/36733444/","study_design":null,"title":"Integration of amyloid-\u03b2 oligomerization tendency as a plasma biomarker in Alzheimer's disease diagnosis","title_match":true,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/recent-diagnostic-techniques-for-the-detection-of-alzheimer-s-disease-36525239","doi":"10.1007/s11845-022-03244-y","journal":"Irish journal of medical science","n_participants":null,"pmid":"36525239","source_url":"https://pubmed.ncbi.nlm.nih.gov/36525239/","study_design":null,"title":"Recent diagnostic techniques for the detection of Alzheimer's disease: a short review","title_match":false,"year":2023},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-quantified-by-the-fully-automated-lumipulse-g-41535718","doi":"10.1038/s41598-025-34241-7","journal":"Scientific reports","n_participants":494,"pmid":"41535718","source_url":"https://pubmed.ncbi.nlm.nih.gov/41535718/","study_design":null,"title":"Plasma p-tau217, quantified by the fully automated LUMIPULSE G platform, outperforms p-tau181 in predicting amyloid pathology in cognitive complaints patients","title_match":true,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/cognitive-impairment-and-p-tau217-are-high-in-a-vascular-patient-40772428","doi":"10.1002/alz.70565","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40772428","source_url":"https://pubmed.ncbi.nlm.nih.gov/40772428/","study_design":null,"title":"Cognitive impairment and p-tau217 are high in a vascular patient cohort","title_match":true,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/tau-pathology-mediated-the-plasma-biomarkers-and-cognitive-function-39128687","doi":"10.1016/j.exger.2024.112535","journal":"Experimental gerontology","n_participants":20,"pmid":"39128687","source_url":"https://pubmed.ncbi.nlm.nih.gov/39128687/","study_design":null,"title":"Tau pathology mediated the plasma biomarkers and cognitive function in patients with mild cognitive impairment","title_match":true,"year":2024},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/sex-specific-biomarkers-in-alzheimer-s-disease-progression-framingham-36348973","doi":"10.1002/dad2.12369","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":1398,"pmid":"36348973","source_url":"https://pubmed.ncbi.nlm.nih.gov/36348973/","study_design":"longitudinal study","title":"Sex-specific biomarkers in Alzheimer's disease progression: Framingham Heart Study","title_match":false,"year":2022},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/plasma-and-csf-neurofilament-light-chain-distinguish-39369278","doi":"10.1002/alz.14278","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":337,"pmid":"39369278","source_url":"https://pubmed.ncbi.nlm.nih.gov/39369278/","study_design":null,"title":"Plasma and CSF neurofilament light chain distinguish neurodegenerative from primary psychiatric conditions in a clinical setting","title_match":false,"year":2024},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/health-related-factors-and-their-impact-on-blood-based-biomarkers-of-42733904","doi":"10.1016/j.nbas.2026.100166","journal":"Aging brain","n_participants":116,"pmid":"42733904","source_url":"https://pubmed.ncbi.nlm.nih.gov/42733904/","study_design":null,"title":"Health-related factors and their impact on blood-based biomarkers of Alzheimer's disease","title_match":true,"year":2026},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-and-plasma-tau-as-a-biomarker-for-brain-tauopathy-32096052","doi":"10.1007/978-981-32-9358-8_29","journal":"Advances in experimental medicine and biology","n_participants":null,"pmid":"32096052","source_url":"https://pubmed.ncbi.nlm.nih.gov/32096052/","study_design":"cohort study","title":"Cerebrospinal Fluid and Plasma Tau as a Biomarker for Brain Tauopathy","title_match":false,"year":2019},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/blood-brain-barrier-permeable-blockers-association-with-alzheimer-s-39584306","doi":"10.1177/13872877241293812","journal":"Journal of Alzheimer's disease : JAD","n_participants":216,"pmid":"39584306","source_url":"https://pubmed.ncbi.nlm.nih.gov/39584306/","study_design":null,"title":"Blood-brain barrier permeable \u03b2-blockers association with Alzheimer's disease cerebrospinal fluid biomarkers levels in non-demented individuals","title_match":false,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-and-plasma-biomarkers-in-neurodegenerative-30814356","doi":"10.3233/jad-181152","journal":"Journal of Alzheimer's disease : JAD","n_participants":213,"pmid":"30814356","source_url":"https://pubmed.ncbi.nlm.nih.gov/30814356/","study_design":null,"title":"Cerebrospinal Fluid and Plasma Biomarkers in Neurodegenerative Diseases","title_match":true,"year":2019},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/elecsys-cerebrospinal-fluid-assays-accurately-distinguish-alzheimer-s-35841250","doi":"10.14283/jpad.2022.27","journal":"The journal of prevention of Alzheimer's disease","n_participants":130,"pmid":"35841250","source_url":"https://pubmed.ncbi.nlm.nih.gov/35841250/","study_design":null,"title":"Elecsys Cerebrospinal Fluid Assays Accurately Distinguish Alzheimer's Disease from Frontotemporal Lobar Degeneration","title_match":false,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/amyloid-imaging-cerebrospinal-fluid-biomarkers-predict-driving-27128959","doi":"10.1097/wad.0000000000000154","journal":"Alzheimer disease and associated disorders","n_participants":129,"pmid":"27128959","source_url":"https://pubmed.ncbi.nlm.nih.gov/27128959/","study_design":null,"title":"Amyloid Imaging, Cerebrospinal Fluid Biomarkers Predict Driving Performance Among Cognitively Normal Individuals","title_match":false,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/staging-of-alzheimer-s-disease-past-present-and-future-perspectives-35717526","doi":"10.1016/j.molmed.2022.05.008","journal":"Trends in molecular medicine","n_participants":null,"pmid":"35717526","source_url":"https://pubmed.ncbi.nlm.nih.gov/35717526/","study_design":null,"title":"Staging of Alzheimer's disease: past, present, and future perspectives","title_match":false,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-tau-p-tau-181-and-amyloid-38-40-42-in-21135556","doi":"10.1159/000322370","journal":"Dementia and geriatric cognitive disorders","n_participants":25,"pmid":"21135556","source_url":"https://pubmed.ncbi.nlm.nih.gov/21135556/","study_design":null,"title":"Cerebrospinal fluid tau, p-tau 181 and amyloid-\u03b238/40/42 in frontotemporal dementias and primary progressive aphasias","title_match":true,"year":2011},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/national-trends-in-cerebrospinal-fluid-biomarker-testing-for-41445784","doi":"10.1177/25424823251410102","journal":"Journal of Alzheimer's disease reports","n_participants":null,"pmid":"41445784","source_url":"https://pubmed.ncbi.nlm.nih.gov/41445784/","study_design":null,"title":"National trends in cerebrospinal fluid biomarker testing for Alzheimer's disease in Japan","title_match":false,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/differences-between-ante-mortem-alzheimer-s-disease-biomarkers-in-36840620","doi":"10.1002/alz.12997","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":100,"pmid":"36840620","source_url":"https://pubmed.ncbi.nlm.nih.gov/36840620/","study_design":null,"title":"Differences between ante mortem Alzheimer's disease biomarkers in predicting neuropathology at autopsy","title_match":false,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/increased-cerebrospinal-fluid-tau-levels-in-logopenic-variant-of-24217280","doi":"10.3233/jad-131382","journal":"Journal of Alzheimer's disease : JAD","n_participants":30,"pmid":"24217280","source_url":"https://pubmed.ncbi.nlm.nih.gov/24217280/","study_design":null,"title":"Increased cerebrospinal fluid tau levels in logopenic variant of Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/neuropsychological-and-behavioural-correlates-of-csf-biomarkers-in-16434124","doi":"10.1016/j.neuint.2005.11.002","journal":"Neurochemistry international","n_participants":201,"pmid":"16434124","source_url":"https://pubmed.ncbi.nlm.nih.gov/16434124/","study_design":null,"title":"Neuropsychological and behavioural correlates of CSF biomarkers in dementia","title_match":false,"year":2006},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-alzheimer-s-biomarkers-and-neurofilament-light-34077945","doi":"10.1159/000514052","journal":"Neuro-degenerative diseases","n_participants":null,"pmid":"34077945","source_url":"https://pubmed.ncbi.nlm.nih.gov/34077945/","study_design":null,"title":"Cerebrospinal Fluid Alzheimer's Biomarkers and Neurofilament Light Profile of Idiopathic Normal Pressure Hydrocephalus in China: A PUMCH Cohort Study","title_match":false,"year":2020},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/speech-digital-biomarker-combined-with-fluid-biomarkers-predict-41121436","doi":"10.1186/s13195-025-01877-6","journal":"Alzheimer's research & therapy","n_participants":238,"pmid":"41121436","source_url":"https://pubmed.ncbi.nlm.nih.gov/41121436/","study_design":null,"title":"Speech digital biomarker combined with fluid biomarkers predict cognitive impairment through machine learning","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-for-early-alzheimer-s-disease-diagnosis-in-38427184","doi":"10.1007/978-1-0716-3774-6_1","journal":"Methods in molecular biology (Clifton, N.J.)","n_participants":null,"pmid":"38427184","source_url":"https://pubmed.ncbi.nlm.nih.gov/38427184/","study_design":null,"title":"Blood-Based Biomarkers for Early Alzheimer's Disease Diagnosis in Real-World Settings","title_match":true,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/atn-blood-biomarkers-are-related-to-digital-cognitive-assessment-in-39445343","doi":"10.1002/dad2.70029","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":114,"pmid":"39445343","source_url":"https://pubmed.ncbi.nlm.nih.gov/39445343/","study_design":null,"title":"ATN blood biomarkers are related to digital cognitive assessment in type 1 diabetes","title_match":false,"year":2024},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/web-based-las-fname-and-blood-biomarkers-in-autosomal-dominant-41737720","doi":"10.1002/dad2.70289","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"41737720","source_url":"https://pubmed.ncbi.nlm.nih.gov/41737720/","study_design":"longitudinal study","title":"Web-based LAS-FNAME and blood biomarkers in autosomal dominant Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/combining-a-computerized-cognitive-test-with-serum-biomarkers-41143873","doi":"10.1177/13872877251389224","journal":"Journal of Alzheimer's disease : JAD","n_participants":54,"pmid":"41143873","source_url":"https://pubmed.ncbi.nlm.nih.gov/41143873/","study_design":null,"title":"Combining a computerized cognitive test with serum biomarkers improves detection of early-onset neurodegenerative disorders","title_match":true,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apoe-differentially-moderates-cerebrospinal-fluid-and-plasma-36780762","doi":"10.1016/j.neurobiolaging.2022.10.016","journal":"Neurobiology of aging","n_participants":727,"pmid":"36780762","source_url":"https://pubmed.ncbi.nlm.nih.gov/36780762/","study_design":null,"title":"APOE differentially moderates cerebrospinal fluid and plasma phosphorylated tau181 associations with multi-domain cognition","title_match":false,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/genome-wide-association-of-tau-neuroimaging-and-plasma-biomarkers-in-40667715","doi":"10.1002/alz.70398","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":375,"pmid":"40667715","source_url":"https://pubmed.ncbi.nlm.nih.gov/40667715/","study_design":null,"title":"Genome-wide association of tau neuroimaging and plasma biomarkers in adults with Down syndrome","title_match":true,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/genetic-risk-scores-enhance-the-diagnostic-value-of-plasma-biomarkers-37279785","doi":"10.1093/brain/awad196","journal":"Brain : a journal of neurology","n_participants":962,"pmid":"37279785","source_url":"https://pubmed.ncbi.nlm.nih.gov/37279785/","study_design":null,"title":"Genetic risk scores enhance the diagnostic value of plasma biomarkers of brain amyloidosis","title_match":true,"year":2023},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/polygenic-risk-for-alzheimer-s-disease-is-associated-with-neuroaxonal-38213949","doi":"10.1002/dad2.12504","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"38213949","source_url":"https://pubmed.ncbi.nlm.nih.gov/38213949/","study_design":"cohort study","title":"Polygenic risk for Alzheimer's disease is associated with neuroaxonal damage before onset of clinical symptoms","title_match":false,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/investigating-the-genetic-characteristics-of-hippocampal-volume-and-35623891","doi":"10.1212/wnl.0000000000200554","journal":"Neurology","n_participants":1261,"pmid":"35623891","source_url":"https://pubmed.ncbi.nlm.nih.gov/35623891/","study_design":null,"title":"Investigating the Genetic Characteristics of Hippocampal Volume and Plasma \u03b2-Amyloid in a Chinese Community-Dwelling Population","title_match":false,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/genetic-study-of-young-onset-dementia-using-targeted-gene-panel-33580635","doi":"10.1002/ajmg.b.32836","journal":"American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics","n_participants":52,"pmid":"33580635","source_url":"https://pubmed.ncbi.nlm.nih.gov/33580635/","study_design":null,"title":"Genetic study of young-onset dementia using targeted gene panel sequencing in Taiwan","title_match":false,"year":2021},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/combining-csf-mtbr-tau243-and-plasma-ptau217-ratio-enhances-the-41170658","doi":"10.1002/alz.70881","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":242,"pmid":"41170658","source_url":"https://pubmed.ncbi.nlm.nih.gov/41170658/","study_design":null,"title":"Combining CSF MTBR-tau243 and plasma pTau217 ratio enhances the prediction of continuous regional tau PET burden in early Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/combining-cerebrospinal-fluid-and-pi-2620-tau-pet-for-biomarker-based-39263969","doi":"10.1002/alz.14185","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":64,"pmid":"39263969","source_url":"https://pubmed.ncbi.nlm.nih.gov/39263969/","study_design":null,"title":"Combining cerebrospinal fluid and PI-2620 tau-PET for biomarker-based stratification of Alzheimer's disease and 4R-tauopathies","title_match":false,"year":2024},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/characterization-of-alzheimer-s-tau-biomarker-discordance-using-33947453","doi":"10.1186/s13195-021-00834-3","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"33947453","source_url":"https://pubmed.ncbi.nlm.nih.gov/33947453/","study_design":"longitudinal study","title":"Characterization of Alzheimer's tau biomarker discordance using plasma, CSF, and PET","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/predicting-continuous-amyloid-pet-values-with-csf-and-plasma-a42-a40-36874595","doi":"10.1002/dad2.12405","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"36874595","source_url":"https://pubmed.ncbi.nlm.nih.gov/36874595/","study_design":null,"title":"Predicting continuous amyloid PET values with CSF and plasma A\u03b242/A\u03b240","title_match":true,"year":2023},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/predicting-amyloid-pet-positivity-using-plasma-p-tau181-and-other-38026758","doi":"10.1002/dad2.12502","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"38026758","source_url":"https://pubmed.ncbi.nlm.nih.gov/38026758/","study_design":"cohort study","title":"Predicting amyloid PET positivity using plasma p-tau181 and other blood-based biomarkers","title_match":true,"year":2023},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/depression-and-alzheimer-s-disease-biomarkers-predict-driving-decline-30400098","doi":"10.3233/jad-180564","journal":"Journal of Alzheimer's disease : JAD","n_participants":131,"pmid":"30400098","source_url":"https://pubmed.ncbi.nlm.nih.gov/30400098/","study_design":null,"title":"Depression and Alzheimer's Disease Biomarkers Predict Driving Decline","title_match":false,"year":2018},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/non-invasive-biomarkers-for-early-detection-of-alzheimer-s-disease-a-37596437","doi":"10.1007/s12035-023-03578-3","journal":"Molecular neurobiology","n_participants":null,"pmid":"37596437","source_url":"https://pubmed.ncbi.nlm.nih.gov/37596437/","study_design":null,"title":"Non-invasive Biomarkers for Early Detection of Alzheimer's Disease: a New-Age Perspective","title_match":false,"year":2024},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/assessing-outer-retinal-and-choroidal-changes-in-scd-potential-for-41315191","doi":"10.1038/s41398-025-03781-x","journal":"Translational psychiatry","n_participants":57,"pmid":"41315191","source_url":"https://pubmed.ncbi.nlm.nih.gov/41315191/","study_design":null,"title":"Assessing outer retinal and choroidal changes in scd: potential for high-risk screening using SS-OCTA","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/overview-of-alzheimer-s-disease-neuroimaging-initiative-and-future-39711072","doi":"10.1002/alz.14321","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39711072","source_url":"https://pubmed.ncbi.nlm.nih.gov/39711072/","study_design":null,"title":"Overview of Alzheimer's Disease Neuroimaging Initiative and future clinical trials","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/maximizing-the-benefit-and-managing-the-risk-of-anti-amyloid-40118715","doi":"10.1016/j.neurot.2025.e00570","journal":"Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics","n_participants":null,"pmid":"40118715","source_url":"https://pubmed.ncbi.nlm.nih.gov/40118715/","study_design":null,"title":"Maximizing the benefit and managing the risk of anti-amyloid monoclonal antibody therapy for Alzheimer's disease: Strategies and research directions","title_match":false,"year":2025},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/amyloid-related-imaging-abnormalities-in-japanese-patients-with-41936348","doi":"10.1016/j.tjpad.2026.100562","journal":"The journal of prevention of Alzheimer's disease","n_participants":120,"pmid":"41936348","source_url":"https://pubmed.ncbi.nlm.nih.gov/41936348/","study_design":"longitudinal study","title":"Amyloid-related imaging abnormalities in Japanese patients with Alzheimer's disease treated with Lecanemab: A real-world study","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/viewpoint-clinicians-perspectives-on-how-disease-modifying-drugs-for-37357267","doi":"10.14283/jpad.2023.72","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"37357267","source_url":"https://pubmed.ncbi.nlm.nih.gov/37357267/","study_design":null,"title":"Viewpoint: Clinicians' Perspectives on How Disease Modifying Drugs for Alzheimer's Disease Impact Specialty Care","title_match":false,"year":2023},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/pharmacodynamic-effects-of-semorinemab-on-plasma-and-csf-biomarkers-39513754","doi":"10.1002/alz.14346","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39513754","source_url":"https://pubmed.ncbi.nlm.nih.gov/39513754/","study_design":"clinical trial","title":"Pharmacodynamic effects of semorinemab on plasma and CSF biomarkers of Alzheimer's disease pathophysiology","title_match":false,"year":2024},{"alzhub_score":81,"alzhub_url":"https://alzhub.org/study/a-phase-2-randomized-placebo-controlled-study-on-the-efficacy-and-40912996","doi":"10.1016/j.tjpad.2025.100337","journal":"The journal of prevention of Alzheimer's disease","n_participants":210,"pmid":"40912996","source_url":"https://pubmed.ncbi.nlm.nih.gov/40912996/","study_design":"clinical trial","title":"A phase 2 randomized, placebo-controlled study on the efficacy and safety of AR1001, a phosphodiesterase-5 inhibitor, in patients with mild-to-moderate Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/a-phase-3-trial-of-iv-immunoglobulin-for-alzheimer-disease-28381506","doi":"10.1212/wnl.0000000000003904","journal":"Neurology","n_participants":390,"pmid":"28381506","source_url":"https://pubmed.ncbi.nlm.nih.gov/28381506/","study_design":"clinical trial","title":"A phase 3 trial of IV immunoglobulin for Alzheimer disease","title_match":false,"year":2017},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/protocol-of-a-phase-ii-randomized-multi-center-double-blind-placebo-37874102","doi":"10.14283/jpad.2023.55","journal":"The journal of prevention of Alzheimer's disease","n_participants":60,"pmid":"37874102","source_url":"https://pubmed.ncbi.nlm.nih.gov/37874102/","study_design":null,"title":"Protocol of a Phase II Randomized, Multi-Center, Double-Blind, Placebo-Controlled Trial of S-Adenosyl Methionine in Participants with Mild Cognitive Impairment or Dementia Due to Alzheimer's Disease","title_match":false,"year":2023},{"alzhub_score":85,"alzhub_url":"https://alzhub.org/study/a-phase-2-randomized-multicenter-double-blind-placebo-controlled-41980907","doi":"10.1002/alz.71381","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":63,"pmid":"41980907","source_url":"https://pubmed.ncbi.nlm.nih.gov/41980907/","study_design":"clinical trial","title":"A phase 2, randomized, multicenter, double-blind, placebo-controlled trial of S-adenosyl methionine in participants with mild cognitive impairment or dementia due to Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":86,"alzhub_url":"https://alzhub.org/study/randomized-double-blind-study-of-zervimesine-in-mild-to-moderate-41930592","doi":"10.1177/13872877261437145","journal":"Journal of Alzheimer's disease : JAD","n_participants":153,"pmid":"41930592","source_url":"https://pubmed.ncbi.nlm.nih.gov/41930592/","study_design":"clinical trial","title":"Randomized, double-blind study of zervimesine in mild to moderate Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/insomnia-symptoms-and-biomarkers-of-alzheimer-s-disease-in-the-36641673","doi":"10.3233/jad-220924","journal":"Journal of Alzheimer's disease : JAD","n_participants":63,"pmid":"36641673","source_url":"https://pubmed.ncbi.nlm.nih.gov/36641673/","study_design":"cross-sectional","title":"Insomnia Symptoms and Biomarkers of Alzheimer's Disease in the Community","title_match":false,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/elevated-circulating-amyloid-concentrations-in-obesity-and-diabetes-32407295","doi":"10.1172/jci122237","journal":"The Journal of clinical investigation","n_participants":null,"pmid":"32407295","source_url":"https://pubmed.ncbi.nlm.nih.gov/32407295/","study_design":null,"title":"Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction","title_match":false,"year":2020},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/cognitive-reserve-cortisol-and-alzheimer-s-disease-biomarkers-a-38837661","doi":"10.1002/alz.13866","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38837661","source_url":"https://pubmed.ncbi.nlm.nih.gov/38837661/","study_design":"cross-sectional","title":"Cognitive reserve, cortisol, and Alzheimer's disease biomarkers: A memory clinic study","title_match":false,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/peripheral-biomarkers-of-neuroinflammation-in-alzheimer-s-disease-and-42150695","doi":"10.1016/j.bcp.2026.118077","journal":"Biochemical pharmacology","n_participants":null,"pmid":"42150695","source_url":"https://pubmed.ncbi.nlm.nih.gov/42150695/","study_design":null,"title":"Peripheral biomarkers of neuroinflammation in Alzheimer's disease and vascular dementia","title_match":false,"year":2026},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-co-pathology-is-associated-with-accelerated-amyloid-40098057","doi":"10.1186/s13024-025-00822-3","journal":"Molecular neurodegeneration","n_participants":384,"pmid":"40098057","source_url":"https://pubmed.ncbi.nlm.nih.gov/40098057/","study_design":"longitudinal study","title":"Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-detects-alzheimer-s-disease-co-pathology-in-cerebral-42552750","doi":"10.1002/alz.71709","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":231,"pmid":"42552750","source_url":"https://pubmed.ncbi.nlm.nih.gov/42552750/","study_design":null,"title":"Plasma p-tau217 detects Alzheimer's disease co-pathology in cerebral amyloid angiopathy: Comparison to CSF biomarkers in the ANGMAR cohort","title_match":true,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/putaminal-hypermetabolism-identifies-lewy-body-co-pathology-in-41273227","doi":"10.1002/alz.70920","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"41273227","source_url":"https://pubmed.ncbi.nlm.nih.gov/41273227/","study_design":null,"title":"Putaminal hypermetabolism identifies Lewy body co-pathology in Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/association-of-csf-synuclein-seed-amplification-assay-positivity-with-39428831","doi":"10.1002/alz.14276","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1637,"pmid":"39428831","source_url":"https://pubmed.ncbi.nlm.nih.gov/39428831/","study_design":"cross-sectional","title":"Association of CSF \u03b1-synuclein seed amplification assay positivity with disease progression and cognitive decline: A longitudinal Alzheimer's Disease Neuroimaging Initiative study","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/neurogranin-and-neuronal-pentraxin-receptor-as-synaptic-dysfunction-34640593","doi":"10.3390/jcm10194575","journal":"Journal of clinical medicine","n_participants":null,"pmid":"34640593","source_url":"https://pubmed.ncbi.nlm.nih.gov/34640593/","study_design":null,"title":"Neurogranin and Neuronal Pentraxin Receptor as Synaptic Dysfunction Biomarkers in Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/ubiquitin-proteasome-system-in-the-different-stages-of-dominantly-39108475","doi":"10.21203/rs.3.rs-4202125/v1","journal":"Research square","n_participants":null,"pmid":"39108475","source_url":"https://pubmed.ncbi.nlm.nih.gov/39108475/","study_design":null,"title":"Ubiquitin-Proteasome System in the Different Stages of Dominantly Inherited Alzheimer's Disease","title_match":false,"year":2024},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/longitudinal-plasma-biomarkers-and-multimodal-pet-across-apoe-4-19abfe03","doi":"10.21203/rs.3.rs-11294615/v1","journal":"Research Square","n_participants":60,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11294615/v1","study_design":"longitudinal study","title":"Longitudinal plasma biomarkers and multimodal PET across APOE \u03b54 genotypes: a prospective cohort study","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/concurrent-cognitive-behavioral-and-systemic-physiological-features-5c090ac9","doi":"10.64898/2026.10.26.761827","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.26.761827","study_design":null,"title":"Concurrent cognitive, behavioral and systemic physiological features mark preclinical Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-across-the-alzheimer-s-disease-continuum-in-650383db","doi":"10.64898/2026.10.27.26366659","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.27.26366659","study_design":"cross-sectional","title":"Blood-based biomarkers across the Alzheimer's disease continuum in older Korean population","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/cognition-in-healthy-aging-ages-36-to-108-associations-with-dementia-4c319601","doi":"10.64898/2026.10.25.26366428","journal":"medRxiv","n_participants":1396,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.25.26366428","study_design":null,"title":"Cognition in healthy aging, ages 36 to 108: Associations with dementia risk factors and neurodegenerative disease biomarkers","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/detection-of-tau-spatial-extent-using-mk6240-and-flortaucipir-pet-5c9de0fb","doi":"10.64898/2026.10.26.26366488","journal":"medRxiv","n_participants":682,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.26.26366488","study_design":null,"title":"Detection of tau spatial extent using MK6240 and flortaucipir PET","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/brain-derived-ptau217-and-plasma-proteomic-profiles-across-cognitive-b635ff16","doi":"10.64898/2026.10.26.26366533","journal":"medRxiv","n_participants":786,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.26.26366533","study_design":null,"title":"Brain-Derived pTau217 and Plasma Proteomic Profiles Across Cognitive and Dementia Groups in Congolese Older Adults","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/plasma-proteomic-correlates-of-cognitive-function-in-older-adults-8134b2bd","doi":"10.64898/2026.10.22.26366214","journal":"medRxiv","n_participants":779,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.22.26366214","study_design":"prospective cohort","title":"Plasma Proteomic Correlates of Cognitive Function in Older Adults From Central Africa","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/plasma-emtbr-tau-as-a-marker-of-clinical-stage-and-progression-across-935d5a9a","doi":"10.64898/2026.10.21.26366056","journal":"medRxiv","n_participants":436,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.21.26366056","study_design":"cohort study","title":"Plasma eMTBR-tau as a marker of clinical stage and progression across the Alzheimer\u2019s disease continuum","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/associations-of-genetic-predisposition-to-alzheimers-disease-with-a6466441","doi":"10.21203/rs.3.rs-11220681/v1","journal":"Research Square","n_participants":3947,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11220681/v1","study_design":null,"title":"Associations of genetic predisposition to Alzheimer\u2019s disease with blood-based biomarkers: a community-based study","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/soluble-amyloid-composition-links-proximal-app-processing-fibrillar-415c6827","doi":"10.21203/rs.3.rs-10955863/v1","journal":"Research Square","n_participants":91,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10955863/v1","study_design":null,"title":"Soluble amyloid composition links proximal APP processing, fibrillar burden and the p-tau181 response","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/synuclein-seed-amplification-status-modifies-the-relationship-between-af4554ea","doi":"10.21203/rs.3.rs-11271891/v1","journal":"Research Square","n_participants":193,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11271891/v1","study_design":"cross-sectional","title":"\u03b1-Synuclein Seed Amplification Status Modifies the Relationship Between Plasma p-tau217, Amyloid and Fibrillar Tau","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-and-incident-clinical-stage-progression-in-the-7d89c156","doi":"10.64898/2026.10.19.26365317","journal":"medRxiv","n_participants":3645,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.19.26365317","study_design":null,"title":"Plasma biomarkers and incident clinical stage progression in the specialized memory clinic: a longitudinal study","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/performance-boundaries-of-plasma-centred-prediction-across-pet-and-c9526c45","doi":"10.64898/2026.10.15.26365631","journal":"medRxiv","n_participants":1097,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.15.26365631","study_design":"post-hoc analysis","title":"Performance boundaries of plasma-centred prediction across PET- and MRI-defined AT(N): QC-first internal validation in ADNI with separate axis-specific assessments","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/basal-ganglia-iron-accumulation-mediates-stage-dependent-associations-cac95d7a","doi":"10.21203/rs.3.rs-11017150/v1","journal":"Research Square","n_participants":94,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11017150/v1","study_design":null,"title":"Basal Ganglia Iron Accumulation Mediates Stage-Dependent Associations Between Plasma pTau217 and Hippocampal Atrophy in Alzheimer\u2019s Disease","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/dna-encoded-library-guided-discovery-of-a-first-in-class-molecular-c1b494a3","doi":"10.64898/2026.10.12.758423","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.12.758423","study_design":null,"title":"DNA-Encoded Library-Guided Discovery of a First-in-Class Molecular Glue of the NOS1AP-SCRIB Complex in Alzheimer\u2019s Disease Patient-Derived Neurons","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-links-mortality-to-neuroaxonal-injury-7dd5e4ea","doi":"10.64898/2026.10.17.26365798","journal":"medRxiv","n_participants":559,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.17.26365798","study_design":null,"title":"Plasma neurofilament light links mortality to neuroaxonal injury beyond clinical decline and Alzheimer disease plasma biomarkers: a multi-cohort study of oldest old individuals","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-is-markedly-elevated-in-general-25f2d41d","doi":"10.64898/2026.10.18.26365854","journal":"medRxiv","n_participants":176,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.18.26365854","study_design":"cross-sectional","title":"Plasma Neurofilament Light Chain is Markedly Elevated in General Hospital Inpatients with Delirium","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/comparative-analysis-of-plasma-ptau217-nfl-and-eight-modifiable-risk-d52f05ae","doi":"10.64898/2026.10.15.26365615","journal":"medRxiv","n_participants":3935,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.15.26365615","study_design":null,"title":"Comparative analysis of plasma pTau217, NfL and eight modifiable risk scores for 11-year dementia prediction in the HUNT Study","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/alzheimers-disease-blood-based-biomarkers-in-the-boston-latino-aging-b88d713c","doi":"10.64898/2026.10.13.26365304","journal":"medRxiv","n_participants":122,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.13.26365304","study_design":"longitudinal study","title":"Alzheimer\u2019s disease blood-based biomarkers in the Boston Latino Aging Study (BLAST): Associations with cognition and depressive symptoms","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/blood-plasma-coenzyme-q-10-and-p-selectin-are-predictive-factors-for-ca662b7e","doi":"10.20944/preprints202610.1228.v1","journal":"Preprints.org","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.20944/preprints202610.1228.v1","study_design":"cross-sectional","title":"Blood Plasma Coenzyme Q 10 and P-Selectin Are Predictive Factors for Mild Cognitive Dysfunction in Elderly Women","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-of-alzheimers-disease-neuropathology-cognition-and-f728d2cc","doi":"10.64898/2026.10.02.26364486","journal":"medRxiv","n_participants":1260,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.02.26364486","study_design":null,"title":"Blood Biomarkers of Alzheimer\u2019s Disease Neuropathology, Cognition, and Response to a Multidomain Lifestyle Intervention: Secondary analysis of the FINGER Randomized Controlled Dementia Risk Reduction Trial","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/a-first-in-class-brain-penetrant-small-molecule-inhibitor-of-the-806f3501","doi":"10.64898/2026.10.01.755865","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.01.755865","study_design":null,"title":"A First-in-Class, Brain-Penetrant Small Molecule Inhibitor of the NOS1AP-Tau Interaction Rescues Tau Pathology In Vivo and Improves Cognition","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/analytical-performance-of-a-delayed-centrifugation-blood-collection-4cc33be6","doi":"10.64898/2026.10.05.26364780","journal":"medRxiv","n_participants":43,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.05.26364780","study_design":null,"title":"Analytical performance of a delayed-centrifugation blood collection tube for remote blood biomarker assessment","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/sex-differences-in-genetic-liability-to-modifiable-alzheimers-disease-c65529a9","doi":"10.64898/2026.10.01.26364536","journal":"medRxiv","n_participants":27751,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.01.26364536","study_design":"systematic review","title":"Sex differences in genetic liability to modifiable Alzheimer\u2019s disease risk factors","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/tau-pet-subtype-modifies-the-association-between-plasma-p-tau217-and-ada7a142","doi":"10.64898/2026.09.25.26363629","journal":"medRxiv","n_participants":396,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.25.26363629","study_design":"cross-sectional","title":"Tau-PET subtype modifies the association between plasma p-tau217 and memory in Alzheimer\u2019s disease","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/does-csf-testing-add-value-after-an-indeterminate-plasma-p-tau217-632475b0","doi":"10.21203/rs.3.rs-10754560/v1","journal":"Research Square","n_participants":283,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10754560/v1","study_design":null,"title":"Does CSF testing add value after an indeterminate plasma p-tau217 result?","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/quantitative-systems-pharmacology-analysis-of-amyloid-aggregation-and-a02492d7","doi":"10.21203/rs.3.rs-10570608/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10570608/v1","study_design":"clinical trial","title":"Quantitative Systems Pharmacology Analysis of Amyloid Aggregation and Hippocampal Atrophy Trajectories in Alzheimer\u2019s Disease by APOE4 Genotype and Valiltramiprosate/ALZ-801 Treatment","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/clinically-relevant-biomarkers-of-alzheimer-s-disease-are-associated-718be203","doi":"10.64898/2026.08.12.744516","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.12.744516","study_design":"cross-sectional","title":"Clinically Relevant Biomarkers of Alzheimer's Disease Are Associated with Age and Cortical Atrophy in Chimpanzees ( Pan troglodytes )","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/plasma-biomarker-profiles-in-a-colombian-cohort-of-heterozygous-apoe3-6c38e2c0","doi":"10.21203/rs.3.rs-10705602/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10705602/v1","study_design":"cross-sectional","title":"Plasma Biomarker Profiles in a Colombian Cohort of Heterozygous APOE3-Christchurch Carriers","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/diagnostic-concordance-between-plasma-p-tau217-and-amyloid-biomarkers-d8ff574a","doi":"10.21203/rs.3.rs-10410778/v1","journal":"Research Square","n_participants":918,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10410778/v1","study_design":"longitudinal study","title":"Diagnostic Concordance Between Plasma p-Tau217 and Amyloid-\u03b2 Biomarkers in Symptomatic Alzheimer's Disease: Evidence From a Chinese Cohort","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/social-isolation-loneliness-and-blood-based-ad-adrd-biomarkers-in-a-1c8d3cb2","doi":"10.64898/2026.08.06.26359882","journal":"medRxiv","n_participants":3862,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.06.26359882","study_design":null,"title":"Social isolation, loneliness, and blood-based AD/ADRD biomarkers in a nationally-representative study of middle-aged and older adults","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/test-retest-reliability-of-plasma-biomarkers-and-digital-cognitive-3b9d2254","doi":"10.21203/rs.3.rs-10016306/v1","journal":"Research Square","n_participants":92,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10016306/v1","study_design":null,"title":"Test-retest reliability of plasma biomarkers and digital cognitive metrics at clinically meaningful timescales","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/epigenetic-clock-trajectories-and-brain-health-in-midlife-23452582","doi":"10.64898/2026.07.16.26358251","journal":"medRxiv","n_participants":2833,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.16.26358251","study_design":null,"title":"Epigenetic Clock Trajectories and Brain Health in Midlife","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/neurovascular-outer-retinal-degeneration-in-presymptomatic-alzheimers-7050e06c","doi":"10.21203/rs.3.rs-10251231/v2","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10251231/v2","study_design":"cross-sectional","title":"Neurovascular Outer Retinal Degeneration in Presymptomatic Alzheimer\u2019s Disease: An Oculomic Biomarker Study","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/plasma-metabolomic-profiling-of-frailty-in-older-adults-at-risk-of-e9617661","doi":"10.64898/2026.10.06.26364906","journal":"medRxiv","n_participants":118,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.06.26364906","study_design":null,"title":"Plasma metabolomic profiling of frailty in older adults at risk of dementia","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/chronic-migraine-and-alzheimers-dementia-a-candidate-mechanistic-8b77381d","doi":"10.20944/preprints202605.0132.v2","journal":"Preprints.org","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.20944/preprints202605.0132.v2","study_design":"case-control study","title":"Chronic Migraine and Alzheimer\u2019s Dementia: A Candidate Mechanistic Route, and the Evidence That Would Test It","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/a-new-frontier-in-cwd-detection-antemortem-plasma-biomarkers-and-6e1d26a2","doi":"10.64898/2026.08.04.742870","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.04.742870","study_design":null,"title":"A New Frontier in CWD Detection: Antemortem Plasma Biomarkers and Behavioral Profiling in Transgenic Mouse Models","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/consensus-risk-modeling-and-uncertainty-quantification-of-alzheimers-3ce20113","doi":"10.64898/2026.07.30.26359341","journal":"medRxiv","n_participants":472,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.30.26359341","study_design":null,"title":"Consensus Risk Modeling and Uncertainty Quantification of Alzheimer\u2019s Disease Using 5ADCSI Plasma Biomarkers and Multiple External Machine-Learning Frameworks","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/association-of-total-and-brain-derived-alzheimers-disease-plasma-2461a135","doi":"10.64898/2026.07.29.26359150","journal":"medRxiv","n_participants":541,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.29.26359150","study_design":"cohort study","title":"Association of total and brain-derived Alzheimer\u2019s disease plasma biomarkers with brain amyloid deposition in a community-based sample","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/decreased-plasma-igf-1-is-associated-with-cortical-atrophy-but-not-aa6728f4","doi":"10.20944/preprints202607.1813.v1","journal":"Preprints.org","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.20944/preprints202607.1813.v1","study_design":null,"title":"Decreased Plasma IGF-1 Is Associated with Cortical Atrophy, But Not Concomitant Cerebrovascular Disease in Alzheimer\u2019s Dementia","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/dissociable-structural-and-molecular-pathways-of-age-related-11572edc","doi":"10.64898/2026.06.29.735429","journal":"bioRxiv","n_participants":146,"pmid":null,"source_url":"https://doi.org/10.64898/2026.06.29.735429","study_design":"longitudinal study","title":"Dissociable structural and molecular pathways of age-related variability in sustained attention","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/genetic-architecture-of-alzheimers-disease-related-plasma-biomarkers-5f0d801a","doi":"10.64898/2025.12.17.25342458","journal":"medRxiv","n_participants":696,"pmid":null,"source_url":"https://doi.org/10.64898/2025.12.17.25342458","study_design":null,"title":"Genetic architecture of Alzheimer\u2019s disease-related plasma biomarkers","title_match":true,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/effect-of-prior-traumatic-brain-injury-on-alzheimers-disease-blood-9b971246","doi":"10.64898/2026.01.13.26344009","journal":"medRxiv","n_participants":93,"pmid":null,"source_url":"https://doi.org/10.64898/2026.01.13.26344009","study_design":"cohort study","title":"Effect of prior traumatic brain injury on Alzheimer\u2019s disease blood biomarkers in Vietnam Veterans","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/proteomic-biomarkers-of-cognitive-function-apoe-4-status-and-dementia-2d2f572b","doi":"10.64898/2026.01.27.26344912","journal":"medRxiv","n_participants":14258,"pmid":null,"source_url":"https://doi.org/10.64898/2026.01.27.26344912","study_design":null,"title":"Proteomic biomarkers of cognitive function, APOE \u03b54 status, and dementia in Generation Scotland","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/atn-classification-and-machine-learned-plasma-biomarker-phenotypes-2e7985ea","doi":"10.64898/2026.01.02.26343331","journal":"medRxiv","n_participants":51,"pmid":null,"source_url":"https://doi.org/10.64898/2026.01.02.26343331","study_design":"longitudinal study","title":"ATN Classification and Machine-Learned Plasma Biomarker Phenotypes Reveal Distinct Alzheimer\u2019s Pathology in a Population-Based Cohort","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/association-of-infections-and-autoimmune-conditions-with-cognition-a-e37446c9","doi":"10.64898/2026.02.13.26346282","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.02.13.26346282","study_design":null,"title":"Association of infections and autoimmune conditions with cognition: a study using self-reported conditions and identifying a novel plasma biomarker","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/predicting-the-age-of-alzheimers-symptom-onset-from-a-blood-test-7d6ebedf","doi":"10.64898/2026.03.26.26349230","journal":"medRxiv","n_participants":83,"pmid":null,"source_url":"https://doi.org/10.64898/2026.03.26.26349230","study_design":"longitudinal study","title":"Predicting the age of Alzheimer\u2019s symptom onset from a blood test: evaluating a prognostic claim","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/csf-alzheimers-disease-biomarkers-in-relation-to-functional-status-65085d45","doi":"10.64898/2026.10.26.26366525","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.26.26366525","study_design":"longitudinal study","title":"CSF Alzheimer\u2019s Disease Biomarkers in Relation to Functional Status and Tofersen Treatment Response in ALS","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/at-n-anchored-multimodal-deep-learning-for-alzheimers-staging-a-88ea4149","doi":"10.20944/preprints202609.2240.v1","journal":"Preprints.org","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.20944/preprints202609.2240.v1","study_design":null,"title":"AT(N)-Anchored Multimodal Deep Learning for Alzheimer\u2019s Staging: A Taxonomy and Continuous Burden Index for Low-Resource Settings","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/locus-coeruleus-intensity-as-a-marker-of-early-stage-alzheimers-1d4e0089","doi":"10.64898/2026.10.07.26364896","journal":"medRxiv","n_participants":163,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.07.26364896","study_design":"longitudinal study","title":"Locus coeruleus intensity as a marker of early-stage Alzheimer\u2019s disease: associations with plasma pTau 217 and memory","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/mri-derived-periventricular-diffusivity-contextualizes-plasma-ptau217-1e5483ae","doi":"10.21203/rs.3.rs-10895317/v1","journal":"Research Square","n_participants":602,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10895317/v1","study_design":null,"title":"MRI-derived periventricular diffusivity contextualizes plasma pTau217 associations with Alzheimer pathology: a discovery\u2013validation study","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/clinical-expression-beyond-measured-alzheimer-disease-molecular-f99a3bc7","doi":"10.21203/rs.3.rs-10847343/v1","journal":"Research Square","n_participants":436,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10847343/v1","study_design":"longitudinal study","title":"Clinical expression beyond measured Alzheimer disease molecular pathology: a discovery and external evaluation study","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/csf-complement-proteins-are-associated-with-early-tau-pathology-and-84f8f39d","doi":"10.64898/2026.08.24.742564","journal":"bioRxiv","n_participants":708,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.24.742564","study_design":null,"title":"CSF complement proteins are associated with early tau pathology and synaptic damage in an asymptomatic population at risk of Alzheimer\u2019s disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/estimating-amyloid-deposition-using-brain-perfusion-spect-in-6cc54487","doi":"10.21203/rs.3.rs-10624411/v1","journal":"Research Square","n_participants":88,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10624411/v1","study_design":null,"title":"Estimating amyloid-\u03b2 deposition using brain perfusion SPECT in Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/multimodal-transformer-based-fusion-of-blood-based-and-digital-2417b906","doi":"10.21203/rs.3.rs-10462750/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10462750/v1","study_design":null,"title":"Multimodal Transformer-Based Fusion of Blood-Based and Digital Biomarkers for Explainable (XAI) Ultra-Early Alzheimer's Disease Detection","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/biomarker-informed-interpretation-of-dyadic-cognitive-function-index-1ed8e428","doi":"10.64898/2026.07.27.26359000","journal":"medRxiv","n_participants":1686,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.27.26359000","study_design":"cross-sectional","title":"Biomarker-Informed Interpretation of Dyadic Cognitive Function Index Scores in Cognitively Unimpaired Older Adults","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/multivariate-blood-biomarkers-capture-resilience-and-resistance-0f2be5f0","doi":"10.64898/2026.08.03.26359415","journal":"medRxiv","n_participants":1009,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.03.26359415","study_design":null,"title":"Multivariate blood biomarkers capture resilience and resistance phenotypes across the Alzheimer\u2019s disease spectrum","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/regional-cerebrospinal-fluid-motility-as-a-key-determinant-of-soluble-89aedc92","doi":"10.21203/rs.3.rs-10530209/v1","journal":"Research Square","n_participants":502,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10530209/v1","study_design":null,"title":"Regional Cerebrospinal Fluid Motility as a Key Determinant of Soluble Amyloid-\u03b2 Levels and Kinetics","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/altered-t1w-t2w-flair-ratio-in-white-matter-hyperintensities-as-an-b5f25332","doi":"10.64898/2026.07.28.26359139","journal":"medRxiv","n_participants":71,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.28.26359139","study_design":"cross-sectional","title":"Altered T1w/T2w-FLAIR Ratio in White Matter Hyperintensities as an Indicator of Structural Integrity Loss: Association with Alzheimer\u2019s Disease and Vascular Dementia","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/deep-nanoparticle-protein-corona-plasma-proteomics-resolves-a-stage-7fb049ee","doi":"10.64898/2026.07.25.740710","journal":"bioRxiv","n_participants":90,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.25.740710","study_design":null,"title":"Deep nanoparticle protein corona plasma proteomics resolves a stage-specific peripheral signature of Alzheimer\u2019s disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/biomarker-variability-limits-individualized-amyloid-time-estimation-d4682f47","doi":"10.64898/2026.07.08.737258","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.08.737258","study_design":null,"title":"Biomarker Variability Limits Individualized Amyloid Time Estimation in Alzheimer Disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/amyloid-and-tau-cerebrospinal-fluid-biomarker-normalization-in-a-1d9e787e","doi":"10.21203/rs.3.rs-10778388/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10778388/v1","study_design":null,"title":"Amyloid and Tau Cerebrospinal Fluid Biomarker Normalization in a Patient with Alzheimer\u2019s Disease treated with Lecanemab: A Case Report","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/active-amyloid-beta-immunization-ameliorates-synapse-loss-and-c4ebe54d","doi":"10.64898/2026.08.10.26359862","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.10.26359862","study_design":null,"title":"Active amyloid beta immunization ameliorates synapse loss and phosphorylated-tau accumulation around remaining plaques for up to 14 years after treatment","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/xpro1595-a-selective-soluble-tnf-neutralizer-in-early-alzheimers-377d6a5b","doi":"10.1101/2025.09.24.25336496","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1101/2025.09.24.25336496","study_design":"clinical trial","title":"XPro1595, a Selective Soluble TNF Neutralizer, in Early Alzheimer\u2019s Disease with Inflammation (ADi): Results from the Phase 2 MINDFuL Trial","title_match":false,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/plasma-ptau-181-exhibits-flat-longitudinal-trajectories-and-weak-eaeb6aee","doi":"10.21203/rs.3.rs-8204349/v1","journal":"Research Square","n_participants":2523,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-8204349/v1","study_design":"cross-sectional","title":"Plasma pTau-181 Exhibits Flat Longitudinal Trajectories and Weak Cognitive Correlation in UK Biobank: Implications for Anti-Tau Antibody Trial Failures","title_match":true,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/new-alzheimers-disease-diagnostics-and-psychological-clinical-24e6bbda","doi":"10.31234/osf.io/sz4ay_v1","journal":"PsyArXiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.31234/osf.io/sz4ay_v1","study_design":"clinical trial","title":"New Alzheimer\u2019s Disease Diagnostics and Psychological Clinical Perspectives","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/hypertension-is-associated-with-better-brain-health-outcomes-in-older-21596d92","doi":"10.21203/rs.3.rs-10731777/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10731777/v1","study_design":null,"title":"Hypertension is associated with better brain health outcomes in older-age asymptomatic carotid disease populations - A Multi-Cohort Study","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/the-role-of-cortisol-in-cns-disease-11-hsd1-inhibition-as-a-potential-7db41b34","doi":"10.20944/preprints202610.1646.v1","journal":"Preprints.org","n_participants":247,"pmid":null,"source_url":"https://doi.org/10.20944/preprints202610.1646.v1","study_design":null,"title":"The Role of Cortisol in CNS Disease \u201311\u03b2-HSD1 Inhibition as a Potential New Therapeutic Strategy for Alzheimer\u2019s Disease and Major Depressive Disorder","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/prenatal-pesticide-exposure-and-early-alzheimer-disease-related-71e2ee29","doi":"10.64898/2026.05.13.26352896","journal":"medRxiv","n_participants":179,"pmid":null,"source_url":"https://doi.org/10.64898/2026.05.13.26352896","study_design":"cohort study","title":"Prenatal Pesticide Exposure and Early Alzheimer Disease-Related Biomarker and Cognitive Changes in Midlife","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/plasma-emtbr-tau-as-a-robust-biomarker-for-alzheimers-disease-tangle-09101ef3","doi":"10.64898/2026.09.29.26363951","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.29.26363951","study_design":null,"title":"Plasma eMTBR-tau as a robust biomarker for Alzheimer\u2019s disease tangle pathology up to 10 years before death","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/person-centredness-in-dementia-diagnosis-detection-a-scoping-review-a07266ec","doi":"10.21203/rs.3.rs-10092382/v1","journal":"Research Square","n_participants":23,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10092382/v1","study_design":"longitudinal study","title":"Person-Centredness in Dementia Diagnosis & Detection: A Scoping Review","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/biomarker-informed-csf-proteomics-reveals-enpp2lpa-lipid-signaling-7155c963","doi":"10.64898/2026.07.08.26357565","journal":"medRxiv","n_participants":500,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.08.26357565","study_design":null,"title":"Biomarker-informed CSF proteomics reveals ENPP2\u2013LPA lipid signaling associated with Alzheimer\u2019s disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/serum-brain-derived-p-tau-217-and-sv2a-reduce-peripheral-interference-d16a4c7b","doi":"10.64898/2026.07.28.26359122","journal":"medRxiv","n_participants":1198,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.28.26359122","study_design":"cross-sectional","title":"Serum brain-derived p-tau 217 and SV2A Reduce Peripheral Interference in Alzheimer\u2019s Disease: A Multicohort Study","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/validation-of-the-self-test-computerised-protect-cognitive-test-5148408c","doi":"10.64898/2026.07.23.26358814","journal":"medRxiv","n_participants":46,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.23.26358814","study_design":null,"title":"Validation of the self-test computerised PROTECT Cognitive Test System for detection of dementia and Mild Cognitive Impairment","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/detecting-preclinical-alzheimers-disease-risk-in-cognitively-normal-7e9f0fc0","doi":"10.64898/2026.01.15.26344226","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.01.15.26344226","study_design":null,"title":"Detecting Preclinical Alzheimer\u2019s Disease Risk in Cognitively Normal Adults Using Speech Acoustics: Validation with Plasma p-Tau217 and APOE-\u03b54 Status","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-ywhag-nptx2-ratio-predicts-clinical-severity-and-4579e717","doi":"10.64898/2026.08.22.746470","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.22.746470","study_design":null,"title":"Cerebrospinal fluid YWHAG:NPTX2 ratio predicts clinical severity and future phenoconversion in frontotemporal lobar degeneration","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/disease-specific-tangle-immunophenotypes-distinguish-hippocampal-ff9cb4d7","doi":"10.64898/2026.08.13.744594","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.13.744594","study_design":null,"title":"Disease-specific tangle immunophenotypes distinguish hippocampal vulnerability in Alzheimer\u2019s disease and Parkinson\u2019s disease dementia","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/alterations-of-gut-microbiota-in-down-syndrome-and-their-association-99c7bc3a","doi":"10.64898/2026.04.03.716276","journal":"bioRxiv","n_participants":58,"pmid":null,"source_url":"https://doi.org/10.64898/2026.04.03.716276","study_design":null,"title":"Alterations of gut microbiota in Down syndrome and their association with Alzheimer\u2019s disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/automated-plasma-phospho-tau217-assays-for-the-diagnosis-of-down-763c19f0","doi":"10.21203/rs.3.rs-7359108/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-7359108/v1","study_design":null,"title":"Automated Plasma Phospho-tau217 Assays for the diagnosis of Down Syndrome-Related Alzheimer's Disease","title_match":false,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/association-of-age-with-clinical-progression-across-plasma-p-tau217-540a9f49","doi":"10.64898/2026.08.08.26359816","journal":"medRxiv","n_participants":3741,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.08.26359816","study_design":"longitudinal study","title":"Association of age with clinical progression across plasma p-tau217 levels","title_match":true,"year":2026},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/longitudinal-cognitive-and-biomarker-changes-in-dominantly-inherited-30217935","doi":"10.1212/wnl.0000000000006277","journal":"Neurology","n_participants":null,"pmid":"30217935","source_url":"https://pubmed.ncbi.nlm.nih.gov/30217935/","study_design":"cross-sectional","title":"Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease","title_match":false,"year":2018},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/population-based-blood-screening-for-pre-clinical-alzheimers-disease-ab059739","doi":"10.1136/jnnp-2022-abn.297","journal":"Journal of Neurology Neurosurgery & Psychiatry","n_participants":543,"pmid":null,"source_url":"https://doi.org/10.1136/jnnp-2022-abn.297","study_design":null,"title":"Population-based blood screening for pre-clinical Alzheimer\u2019s disease: a British birth cohort at age 70","title_match":false,"year":2022},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/alzheimers-disease-biomarkers-and-future-decline-in-cognitive-normal-29036824","doi":"10.3233/jad-170511","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"29036824","source_url":"https://pubmed.ncbi.nlm.nih.gov/29036824/","study_design":"longitudinal study","title":"Alzheimer\u2019s Disease Biomarkers and Future Decline in Cognitive Normal Older Adults","title_match":false,"year":2017},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/insulin-resistance-is-associated-with-increased-levels-of-27079723","doi":"10.3233/jad-160110","journal":"Journal of Alzheimer s Disease","n_participants":70,"pmid":"27079723","source_url":"https://pubmed.ncbi.nlm.nih.gov/27079723/","study_design":null,"title":"Insulin Resistance is Associated with Increased Levels of Cerebrospinal Fluid Biomarkers of Alzheimer\u2019s Disease and Reduced Memory Function in At-Risk Healthy Middle-Aged Adults","title_match":false,"year":2016},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/estimation-of-tau-and-phosphorylated-tau181-in-serum-of-alzheimers-27459603","doi":"10.1371/journal.pone.0159099","journal":"PLoS ONE","n_participants":null,"pmid":"27459603","source_url":"https://pubmed.ncbi.nlm.nih.gov/27459603/","study_design":null,"title":"Estimation of Tau and Phosphorylated Tau181 in Serum of Alzheimer\u2019s Disease and Mild Cognitive Impairment Patients","title_match":false,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/dna-hypomethylation-in-blood-links-b3galt4-and-zadh2-to-alzheimers-30372681","doi":"10.3233/jad-180592","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"30372681","source_url":"https://pubmed.ncbi.nlm.nih.gov/30372681/","study_design":null,"title":"DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer\u2019s Disease","title_match":false,"year":2018},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/impact-of-harmonization-of-collection-tubes-on-alzheimer-s-disease-24269268","doi":"10.1016/j.jalz.2013.06.008","journal":"Alzheimer s & Dementia","n_participants":1966,"pmid":"24269268","source_url":"https://pubmed.ncbi.nlm.nih.gov/24269268/","study_design":null,"title":"Impact of harmonization of collection tubes on Alzheimer's disease diagnosis","title_match":false,"year":2013},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-differentiate-parkinsons-disease-from-atypical-29755341","doi":"10.3389/fnagi.2018.00123","journal":"Frontiers in Aging Neuroscience","n_participants":204,"pmid":"29755341","source_url":"https://pubmed.ncbi.nlm.nih.gov/29755341/","study_design":null,"title":"Plasma Biomarkers Differentiate Parkinson\u2019s Disease From Atypical Parkinsonism Syndromes","title_match":true,"year":2018},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/increased-plasma-neurofilament-light-chain-concentration-correlates-30626432","doi":"10.1186/s40478-018-0649-3","journal":"Acta Neuropathologica Communications","n_participants":12,"pmid":"30626432","source_url":"https://pubmed.ncbi.nlm.nih.gov/30626432/","study_design":"longitudinal study","title":"Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration","title_match":false,"year":2019},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/vertical-graphene-based-printed-electrochemical-biosensor-for-37622844","doi":"10.3390/bios13080758","journal":"Biosensors","n_participants":null,"pmid":"37622844","source_url":"https://pubmed.ncbi.nlm.nih.gov/37622844/","study_design":null,"title":"Vertical Graphene-Based Printed Electrochemical Biosensor for Simultaneous Detection of Four Alzheimer\u2019s Disease Blood Biomarkers","title_match":false,"year":2023},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/intranasal-insulin-administration-dose-dependently-modulates-verbal-18430999","doi":"10.3233/jad-2008-13309","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"18430999","source_url":"https://pubmed.ncbi.nlm.nih.gov/18430999/","study_design":null,"title":"Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-\u03b2 in Memory-Impaired Older Adults","title_match":true,"year":2008},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/intravenous-immunoglobulin-for-alzheimer-s-disease-25546751","doi":"10.1111/cei.12500","journal":"Clinical & Experimental Immunology","n_participants":16,"pmid":"25546751","source_url":"https://pubmed.ncbi.nlm.nih.gov/25546751/","study_design":"open-label trial","title":"Intravenous immunoglobulin for Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/blood-based-protein-biomarkers-for-diagnosis-of-alzheimer-disease-22801742","doi":"10.1001/archneurol.2012.1282","journal":"Archives of Neurology","n_participants":207,"pmid":"22801742","source_url":"https://pubmed.ncbi.nlm.nih.gov/22801742/","study_design":"longitudinal study","title":"Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease","title_match":false,"year":2012},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-csf-p-tau181-a42-ratio-offers-a-good-accuracy-in-vivo-in-the-193bead1","doi":"10.2174/1567205016666190725150836","journal":"Current Alzheimer Research","n_participants":526,"pmid":null,"source_url":"https://doi.org/10.2174/1567205016666190725150836","study_design":null,"title":"The CSF p-tau181/A\u03b242 Ratio Offers a Good Accuracy \u201cIn Vivo\u201d in the Differential Diagnosis of Alzheimer\u2019s Dementia","title_match":true,"year":2019},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/association-of-plasma-p-tau181-with-memory-decline-in-non-demented-cf62d2ac","doi":"10.1093/braincomms/fcab136","journal":"Brain Communications","n_participants":604,"pmid":null,"source_url":"https://doi.org/10.1093/braincomms/fcab136","study_design":"longitudinal study","title":"Association of plasma P-tau181 with memory decline in non-demented adults","title_match":true,"year":2021},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/abundance-of-nef-and-p-tau217-in-brains-of-individuals-diagnosed-with-6ee68b9d","doi":"10.1007/s12035-021-02608-2","journal":"Molecular Neurobiology","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1007/s12035-021-02608-2","study_design":null,"title":"Abundance of Nef and p-Tau217 in Brains of Individuals Diagnosed with HIV-Associated Neurocognitive Disorders Correlate with Disease Severance","title_match":true,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/association-of-apoe-4-and-plasma-p-tau181-with-preclinical-alzheimers-2b804420","doi":"10.3233/jad-210673","journal":"Journal of Alzheimer's Disease","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.3233/jad-210673","study_design":"longitudinal study","title":"Association of APOE \u025b4 and Plasma p-tau181 with Preclinical Alzheimer\u2019s Disease and Longitudinal Change in Hippocampus Function","title_match":true,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/fluorescent-aptasensor-and-colorimetric-aptablot-for-p-tau231-7161ac9f","doi":"10.3390/biomedicines10010093","journal":"Biomedicines","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.3390/biomedicines10010093","study_design":null,"title":"Fluorescent Aptasensor and Colorimetric Aptablot for p-tau231 Detection: Toward Early Diagnosis of Alzheimer\u2019s Disease","title_match":true,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-and-p-tau181-and-risk-of-psychosis-in-8f209bfc","doi":"10.3233/jpd-223182","journal":"Journal of Parkinson's Disease","n_participants":63,"pmid":null,"source_url":"https://doi.org/10.3233/jpd-223182","study_design":null,"title":"Plasma Neurofilament Light and p-tau181 and Risk of Psychosis in Parkinson\u2019s Disease","title_match":true,"year":2022},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau181-is-a-predictor-of-post-stroke-cognitive-bbbbe568","doi":"10.3389/fnagi.2022.889101","journal":"Frontiers in Aging Neuroscience","n_participants":136,"pmid":null,"source_url":"https://doi.org/10.3389/fnagi.2022.889101","study_design":"longitudinal study","title":"Plasma Phosphorylated-tau181 Is a Predictor of Post-stroke Cognitive Impairment: A Longitudinal Study","title_match":false,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/plasma-p-tau181-for-the-discrimination-of-alzheimers-disease-from-f284f7df","doi":"10.3390/biom12081099","journal":"Biomolecules","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.3390/biom12081099","study_design":null,"title":"Plasma P-Tau181 for the Discrimination of Alzheimer\u2019s Disease from Other Primary Dementing and/or Movement Disorders","title_match":true,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-p-tau181-neurofilament-light-chain-and-association-with-c7b91a06","doi":"10.1038/s41531-022-00384-x","journal":"npj Parkinson's Disease","n_participants":136,"pmid":null,"source_url":"https://doi.org/10.1038/s41531-022-00384-x","study_design":"cross-sectional","title":"Plasma p-tau181, neurofilament light chain and association with cognition in Parkinson\u2019s disease","title_match":true,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/revised-criteria-for-diagnosis-and-staging-of-alzheimer-s-disease-38934362","doi":"10.1002/alz.13859","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38934362","source_url":"https://pubmed.ncbi.nlm.nih.gov/38934362/","study_design":null,"title":"Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup","title_match":false,"year":2024},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/plasma-phospho-tau217-for-alzheimer-s-disease-diagnosis-in-primary-40205199","doi":"10.1038/s41591-025-03622-w","journal":"Nature medicine","n_participants":337,"pmid":"40205199","source_url":"https://pubmed.ncbi.nlm.nih.gov/40205199/","study_design":null,"title":"Plasma phospho-tau217 for Alzheimer's disease diagnosis in primary and secondary care using a fully automated platform","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/clinical-validation-of-the-precivityad2-blood-test-a-mass-38491912","doi":"10.1002/alz.13764","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":583,"pmid":"38491912","source_url":"https://pubmed.ncbi.nlm.nih.gov/38491912/","study_design":null,"title":"Clinical validation of the PrecivityAD2 blood test: A mass spectrometry-based test with algorithm combining %p-tau217 and A\u03b242/40 ratio to identify presence of brain amyloid","title_match":true,"year":2024},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/diagnostic-accuracy-of-phosphorylated-tau217-in-detecting-alzheimer-s-39711334","doi":"10.1002/alz.14458","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39711334","source_url":"https://pubmed.ncbi.nlm.nih.gov/39711334/","study_design":null,"title":"Diagnostic accuracy of phosphorylated tau217 in detecting Alzheimer's disease pathology among cognitively impaired and unimpaired: A systematic review and meta-analysis","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/lower-cerebrospinal-fluid-concentration-of-brain-derived-neurotrophic-26138246","doi":"10.1007/s12017-015-8361-y","journal":"Neuromolecular medicine","n_participants":128,"pmid":"26138246","source_url":"https://pubmed.ncbi.nlm.nih.gov/26138246/","study_design":null,"title":"Lower Cerebrospinal Fluid Concentration of Brain-Derived Neurotrophic Factor Predicts Progression from Mild Cognitive Impairment to Alzheimer's Disease","title_match":false,"year":2015},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/elevated-plasma-phosphorylated-tau-181-in-amyotrophic-lateral-35877814","doi":"10.1002/ana.26462","journal":"Annals of neurology","n_participants":130,"pmid":"35877814","source_url":"https://pubmed.ncbi.nlm.nih.gov/35877814/","study_design":null,"title":"Elevated Plasma Phosphorylated Tau 181 in Amyotrophic Lateral Sclerosis","title_match":false,"year":2022},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/head-to-head-comparison-between-plasma-p-tau217-and-flortaucipir-pet-37740209","doi":"10.1186/s13195-023-01302-w","journal":"Alzheimer's research & therapy","n_participants":85,"pmid":"37740209","source_url":"https://pubmed.ncbi.nlm.nih.gov/37740209/","study_design":"longitudinal study","title":"Head-to-head comparison between plasma p-tau217 and flortaucipir-PET in amyloid-positive patients with cognitive impairment","title_match":true,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/galectin-3-is-elevated-in-csf-and-is-associated-with-a-deposits-and-35895141","doi":"10.1007/s00401-022-02469-6","journal":"Acta neuropathologica","n_participants":119,"pmid":"35895141","source_url":"https://pubmed.ncbi.nlm.nih.gov/35895141/","study_design":null,"title":"Galectin-3 is elevated in CSF and is associated with A\u03b2 deposits and tau aggregates in brain tissue in Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/clinical-evaluation-of-a-novel-plasma-ptau217-38182740","doi":"10.1038/s41598-024-51334-x","journal":"Scientific reports","n_participants":131,"pmid":"38182740","source_url":"https://pubmed.ncbi.nlm.nih.gov/38182740/","study_design":null,"title":"Clinical evaluation of a novel plasma pTau217 electrochemiluminescence immunoassay in Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/association-of-plasma-biomarkers-with-cognition-cognitive-decline-and-38105605","doi":"10.1002/alz.13560","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":480,"pmid":"38105605","source_url":"https://pubmed.ncbi.nlm.nih.gov/38105605/","study_design":null,"title":"Association of plasma biomarkers with cognition, cognitive decline, and daily function across and within neurodegenerative diseases: Results from the Ontario Neurodegenerative Disease Research Initiative","title_match":true,"year":2024},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/elevated-csf-angiopoietin-2-correlates-with-blood-brain-barrier-38182581","doi":"10.1038/s41398-023-02706-w","journal":"Translational psychiatry","n_participants":121,"pmid":"38182581","source_url":"https://pubmed.ncbi.nlm.nih.gov/38182581/","study_design":null,"title":"Elevated CSF angiopoietin-2 correlates with blood-brain barrier leakiness and markers of neuronal injury in early Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/ultrasensitive-assays-for-detection-of-plasma-tau-and-phosphorylated-33712071","doi":"10.1186/s40035-021-00234-5","journal":"Translational neurodegeneration","n_participants":null,"pmid":"33712071","source_url":"https://pubmed.ncbi.nlm.nih.gov/33712071/","study_design":"meta-analysis","title":"Ultrasensitive assays for detection of plasma tau and phosphorylated tau 181 in Alzheimer's disease: a systematic review and meta-analysis","title_match":false,"year":2021},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/blood-phosphorylated-tau-for-the-diagnosis-of-alzheimer-s-disease-a-40818474","doi":"10.1016/s1474-4422(25)00227-3","journal":"The Lancet. Neurology","n_participants":null,"pmid":"40818474","source_url":"https://pubmed.ncbi.nlm.nih.gov/40818474/","study_design":"systematic review","title":"Blood phosphorylated tau for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/clinical-value-of-plasma-alzpath-ptau217-immunoassay-for-assessing-38658136","doi":"10.1136/jnnp-2024-333467","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"38658136","source_url":"https://pubmed.ncbi.nlm.nih.gov/38658136/","study_design":null,"title":"Clinical value of plasma ALZpath pTau217 immunoassay for assessing mild cognitive impairment","title_match":true,"year":2024},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/cognitive-variability-predicts-incident-alzheimer-s-disease-and-mild-29125485","doi":"10.3233/jad-170498","journal":"Journal of Alzheimer's disease : JAD","n_participants":105,"pmid":"29125485","source_url":"https://pubmed.ncbi.nlm.nih.gov/29125485/","study_design":"longitudinal study","title":"Cognitive Variability Predicts Incident Alzheimer's Disease and Mild Cognitive Impairment Comparable to a Cerebrospinal Fluid Biomarker","title_match":false,"year":2018},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/longitudinal-phospho-tau217-predicts-amyloid-positron-emission-39044490","doi":"10.14283/jpad.2024.134","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"39044490","source_url":"https://pubmed.ncbi.nlm.nih.gov/39044490/","study_design":"longitudinal study","title":"Longitudinal Phospho-tau217 Predicts Amyloid Positron Emission Tomography in Asymptomatic Alzheimer's Disease","title_match":false,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/csf-biomarkers-and-plasma-p-tau181-as-predictors-of-longitudinal-tau-35226405","doi":"10.1002/alz.12570","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":163,"pmid":"35226405","source_url":"https://pubmed.ncbi.nlm.nih.gov/35226405/","study_design":null,"title":"CSF biomarkers and plasma p-tau181 as predictors of longitudinal tau accumulation: Implications for clinical trial design","title_match":true,"year":2022},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-sphingolipids-amyloid-and-tau-in-adults-at-risk-24952994","doi":"10.1016/j.neurobiolaging.2014.05.019","journal":"Neurobiology of aging","n_participants":null,"pmid":"24952994","source_url":"https://pubmed.ncbi.nlm.nih.gov/24952994/","study_design":null,"title":"Cerebrospinal fluid sphingolipids, \u03b2-amyloid, and tau in adults at risk for Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/plasma-p-tau212-antemortem-diagnostic-performance-and-prediction-of-38521766","doi":"10.1038/s41467-024-46876-7","journal":"Nature communications","n_participants":388,"pmid":"38521766","source_url":"https://pubmed.ncbi.nlm.nih.gov/38521766/","study_design":null,"title":"Plasma p-tau212 antemortem diagnostic performance and prediction of autopsy verification of Alzheimer's disease neuropathology","title_match":true,"year":2024},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/comparison-of-plasma-and-csf-biomarkers-across-ethnoracial-groups-in-35510092","doi":"10.1002/dad2.12315","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"35510092","source_url":"https://pubmed.ncbi.nlm.nih.gov/35510092/","study_design":"cross-sectional","title":"Comparison of plasma and CSF biomarkers across ethnoracial groups in the ADNI","title_match":false,"year":2022},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/decreasing-body-mass-index-is-associated-with-cerebrospinal-fluid-29054536","doi":"10.1016/j.exger.2017.10.013","journal":"Experimental gerontology","n_participants":null,"pmid":"29054536","source_url":"https://pubmed.ncbi.nlm.nih.gov/29054536/","study_design":null,"title":"Decreasing body mass index is associated with cerebrospinal fluid markers of Alzheimer's pathology in MCI and mild dementia","title_match":false,"year":2017},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/validation-of-alzheimer-s-disease-csf-and-plasma-biological-markers-19539742","doi":"10.1016/j.exger.2009.06.003","journal":"Experimental gerontology","n_participants":49,"pmid":"19539742","source_url":"https://pubmed.ncbi.nlm.nih.gov/19539742/","study_design":null,"title":"Validation of Alzheimer's disease CSF and plasma biological markers: the multicentre reliability study of the pilot European Alzheimer's Disease Neuroimaging Initiative (E-ADNI)","title_match":false,"year":2009},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/matrix-metalloproteinase-10-is-linked-to-the-risk-of-progression-to-35088840","doi":"10.1093/brain/awac024","journal":"Brain : a journal of neurology","n_participants":410,"pmid":"35088840","source_url":"https://pubmed.ncbi.nlm.nih.gov/35088840/","study_design":"longitudinal study","title":"Matrix metalloproteinase 10 is linked to the risk of progression to dementia of the Alzheimer's type","title_match":false,"year":2022},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/association-of-plasma-p-tau181-with-memory-decline-in-non-demented-34222875","doi":"10.1093/braincomms/fcab136","journal":"Brain communications","n_participants":604,"pmid":"34222875","source_url":"https://pubmed.ncbi.nlm.nih.gov/34222875/","study_design":"longitudinal study","title":"Association of plasma P-tau181 with memory decline in non-demented adults","title_match":true,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/dissociation-between-csf-total-tau-and-tau-protein-phosphorylated-at-16298235","doi":"10.1016/j.neurobiolaging.2004.12.003","journal":"Neurobiology of aging","n_participants":null,"pmid":"16298235","source_url":"https://pubmed.ncbi.nlm.nih.gov/16298235/","study_design":null,"title":"Dissociation between CSF total tau and tau protein phosphorylated at threonine 231 in Creutzfeldt-Jakob disease","title_match":false,"year":2006},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/optimal-blood-tau-species-for-the-detection-of-alzheimer-s-disease-38159140","doi":"10.1007/s00401-023-02660-3","journal":"Acta neuropathologica","n_participants":123,"pmid":"38159140","source_url":"https://pubmed.ncbi.nlm.nih.gov/38159140/","study_design":null,"title":"Optimal blood tau species for the detection of Alzheimer's disease neuropathology: an immunoprecipitation mass spectrometry and autopsy study","title_match":false,"year":2023},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-efficacy-of-plasma-biomarkers-in-early-diagnosis-of-alzheimer-s-24318929","doi":"10.1002/gps.4053","journal":"International journal of geriatric psychiatry","n_participants":null,"pmid":"24318929","source_url":"https://pubmed.ncbi.nlm.nih.gov/24318929/","study_design":null,"title":"The efficacy of plasma biomarkers in early diagnosis of Alzheimer's disease","title_match":true,"year":2014},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/transcranial-blood-brain-barrier-opening-in-alzheimer-s-disease-39113808","doi":"10.7150/thno.94206","journal":"Theranostics","n_participants":null,"pmid":"39113808","source_url":"https://pubmed.ncbi.nlm.nih.gov/39113808/","study_design":"clinical trial","title":"Transcranial blood-brain barrier opening in Alzheimer's disease patients using a portable focused ultrasound system with real-time 2-D cavitation mapping","title_match":false,"year":2024},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/predictive-value-of-cerebrospinal-fluid-visinin-like-protein-1-levels-26836160","doi":"10.3233/jad-150705","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"26836160","source_url":"https://pubmed.ncbi.nlm.nih.gov/26836160/","study_design":null,"title":"Predictive Value of Cerebrospinal Fluid Visinin-Like Protein-1 Levels for Alzheimer's Disease Early Detection and Differential Diagnosis in Patients with Mild Cognitive Impairment","title_match":false,"year":2016},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/accuracy-of-plasma-a40-a42-and-p-tau181-to-detect-csf-alzheimer-s-37784138","doi":"10.1186/s13195-023-01319-1","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"37784138","source_url":"https://pubmed.ncbi.nlm.nih.gov/37784138/","study_design":null,"title":"Accuracy of plasma A\u03b240, A\u03b242, and p-tau181 to detect CSF Alzheimer's pathological changes in cognitively unimpaired subjects using the Lumipulse automated platform","title_match":true,"year":2023},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/elevated-plasma-p-tau181-levels-unrelated-to-alzheimer-s-disease-37012065","doi":"10.1136/jnnp-2022-330709","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":39,"pmid":"37012065","source_url":"https://pubmed.ncbi.nlm.nih.gov/37012065/","study_design":"longitudinal study","title":"Elevated plasma p-tau181 levels unrelated to Alzheimer's disease pathology in amyotrophic lateral sclerosis","title_match":true,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/n-terminal-and-mid-region-tau-fragments-as-fluid-biomarkers-in-35311972","doi":"10.1093/brain/awab481","journal":"Brain : a journal of neurology","n_participants":342,"pmid":"35311972","source_url":"https://pubmed.ncbi.nlm.nih.gov/35311972/","study_design":null,"title":"N-terminal and mid-region tau fragments as fluid biomarkers in neurological diseases","title_match":false,"year":2022},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/blood-based-atn-biomarkers-of-alzheimer-s-disease-a-meta-analysis-33252080","doi":"10.3233/jad-200900","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"33252080","source_url":"https://pubmed.ncbi.nlm.nih.gov/33252080/","study_design":"meta-analysis","title":"Blood-Based ATN Biomarkers of Alzheimer's Disease: A Meta-Analysis","title_match":false,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-ptau217-predicts-continuous-brain-amyloid-levels-in-38940656","doi":"10.1002/alz.14073","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38940656","source_url":"https://pubmed.ncbi.nlm.nih.gov/38940656/","study_design":null,"title":"Plasma pTau217 predicts continuous brain amyloid levels in preclinical and early Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/apoe4-potentiates-amyloid-effects-on-longitudinal-tau-pathology-37749258","doi":"10.1038/s43587-023-00490-2","journal":"Nature aging","n_participants":94,"pmid":"37749258","source_url":"https://pubmed.ncbi.nlm.nih.gov/37749258/","study_design":"longitudinal study","title":"APOE\u03b54 potentiates amyloid \u03b2 effects on longitudinal tau pathology","title_match":false,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/longitudinal-cerebrospinal-fluid-tau-load-increases-in-mild-cognitive-12429378","doi":"10.1016/s0304-3940(02)01038-8","journal":"Neuroscience letters","n_participants":null,"pmid":"12429378","source_url":"https://pubmed.ncbi.nlm.nih.gov/12429378/","study_design":"cross-sectional","title":"Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment","title_match":false,"year":2002},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/plasma-n-terminal-containing-tau-fragments-nta-tau-a-biomarker-of-tau-38365825","doi":"10.1186/s13024-024-00707-x","journal":"Molecular neurodegeneration","n_participants":1294,"pmid":"38365825","source_url":"https://pubmed.ncbi.nlm.nih.gov/38365825/","study_design":"longitudinal study","title":"Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer's Disease","title_match":false,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/changes-in-csf-spdgfr-level-and-their-association-with-blood-brain-36915135","doi":"10.1186/s13195-023-01199-5","journal":"Alzheimer's research & therapy","n_participants":158,"pmid":"36915135","source_url":"https://pubmed.ncbi.nlm.nih.gov/36915135/","study_design":null,"title":"Changes in CSF sPDGFR\u03b2 level and their association with blood-brain barrier breakdown in Alzheimer's disease with or without small cerebrovascular lesions","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/acute-phase-markers-in-csf-reveal-inflammatory-changes-in-alzheimer-s-32882319","doi":"10.1016/j.pneurobio.2020.101904","journal":"Progress in neurobiology","n_participants":1291,"pmid":"32882319","source_url":"https://pubmed.ncbi.nlm.nih.gov/32882319/","study_design":null,"title":"Acute phase markers in CSF reveal inflammatory changes in Alzheimer's disease that intersect with pathology, APOE \u03b54, sex and age","title_match":false,"year":2021},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/benchmarking-of-a-multi-biomarker-low-volume-panel-for-alzheimer-s-39575871","doi":"10.1002/alz.14413","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39575871","source_url":"https://pubmed.ncbi.nlm.nih.gov/39575871/","study_design":null,"title":"Benchmarking of a multi-biomarker low-volume panel for Alzheimer's disease and related dementia research","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/fully-automated-measurement-of-plasma-a42-40-and-p-tau181-analytical-38323780","doi":"10.1002/alz.13687","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":450,"pmid":"38323780","source_url":"https://pubmed.ncbi.nlm.nih.gov/38323780/","study_design":null,"title":"Fully automated measurement of plasma A\u03b242/40 and p-tau181: Analytical robustness and concordance with cerebrospinal fluid profile along the Alzheimer's disease continuum in two independent cohorts","title_match":true,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/increased-cerebrospinal-fluid-levels-of-ubiquitin-carboxyl-terminal-27504117","doi":"10.1159/000447239","journal":"Dementia and geriatric cognitive disorders extra","n_participants":null,"pmid":"27504117","source_url":"https://pubmed.ncbi.nlm.nih.gov/27504117/","study_design":null,"title":"Increased Cerebrospinal Fluid Levels of Ubiquitin Carboxyl-Terminal Hydrolase L1 in Patients with Alzheimer's Disease","title_match":false,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/multimodal-prediction-of-dementia-with-up-to-10-years-follow-up-the-25201779","doi":"10.3233/jad-141053","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"25201779","source_url":"https://pubmed.ncbi.nlm.nih.gov/25201779/","study_design":null,"title":"Multimodal prediction of dementia with up to 10 years follow up: the Gothenburg MCI study","title_match":false,"year":2015},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/longitudinal-plasma-phosphorylated-tau217-and-other-related-38970274","doi":"10.1002/alz.14100","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38970274","source_url":"https://pubmed.ncbi.nlm.nih.gov/38970274/","study_design":"longitudinal study","title":"Longitudinal plasma phosphorylated-tau217 and other related biomarkers in a non-demented Alzheimer's risk-enhanced sample","title_match":false,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/associations-between-cerebrospinal-fluid-biomarkers-and-cognition-in-26599300","doi":"10.3233/jpd-150682","journal":"Journal of Parkinson's disease","n_participants":null,"pmid":"26599300","source_url":"https://pubmed.ncbi.nlm.nih.gov/26599300/","study_design":"cohort study","title":"Associations between Cerebrospinal Fluid Biomarkers and Cognition in Early Untreated Parkinson's Disease","title_match":false,"year":2015},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/diagnostic-value-of-csf-protein-profile-in-a-portuguese-population-of-19418113","doi":"10.1007/s00415-009-5160-0","journal":"Journal of neurology","n_participants":71,"pmid":"19418113","source_url":"https://pubmed.ncbi.nlm.nih.gov/19418113/","study_design":null,"title":"Diagnostic value of CSF protein profile in a Portuguese population of sCJD patients","title_match":false,"year":2009},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/ad-with-subcortical-white-matter-lesions-and-vascular-dementia-csf-15990115","doi":"10.1016/j.jns.2005.05.016","journal":"Journal of the neurological sciences","n_participants":35,"pmid":"15990115","source_url":"https://pubmed.ncbi.nlm.nih.gov/15990115/","study_design":null,"title":"AD with subcortical white matter lesions and vascular dementia: CSF markers for differential diagnosis","title_match":false,"year":2005},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amyloid-and-tau-dynamics-in-human-brain-interstitial-fluid-in-25720406","doi":"10.3233/jad-142862","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"25720406","source_url":"https://pubmed.ncbi.nlm.nih.gov/25720406/","study_design":null,"title":"Amyloid-\u03b2 and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus","title_match":false,"year":2015},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/utility-of-blood-based-tau-biomarkers-for-mild-cognitive-impairment-37190093","doi":"10.3390/cells12081184","journal":"Cells","n_participants":null,"pmid":"37190093","source_url":"https://pubmed.ncbi.nlm.nih.gov/37190093/","study_design":"meta-analysis","title":"Utility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer's Disease: Systematic Review and Meta-Analysis","title_match":false,"year":2023},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/homocysteine-metabolism-and-cerebrospinal-fluid-markers-for-alzheimer-19661622","doi":"10.3233/jad-2009-1187","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"19661622","source_url":"https://pubmed.ncbi.nlm.nih.gov/19661622/","study_design":null,"title":"Homocysteine metabolism and cerebrospinal fluid markers for Alzheimer's disease","title_match":false,"year":2009},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/similar-brain-proteomic-signatures-in-alzheimer-s-disease-and-epilepsy-38289539","doi":"10.1007/s00401-024-02683-4","journal":"Acta neuropathologica","n_participants":null,"pmid":"38289539","source_url":"https://pubmed.ncbi.nlm.nih.gov/38289539/","study_design":null,"title":"Similar brain proteomic signatures in Alzheimer's disease and epilepsy","title_match":false,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/clinical-and-biological-relevance-of-glial-fibrillary-acidic-protein-37924152","doi":"10.1186/s13195-023-01340-4","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"37924152","source_url":"https://pubmed.ncbi.nlm.nih.gov/37924152/","study_design":null,"title":"Clinical and biological relevance of glial fibrillary acidic protein in Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/associations-between-plasma-biomarkers-and-cognition-in-patients-with-31698867","doi":"10.3390/jcm8111893","journal":"Journal of clinical medicine","n_participants":40,"pmid":"31698867","source_url":"https://pubmed.ncbi.nlm.nih.gov/31698867/","study_design":"cross-sectional","title":"Associations between Plasma Biomarkers and Cognition in Patients with Alzheimer's Disease and Amnestic Mild Cognitive Impairment: A Cross-Sectional and Longitudinal Study","title_match":true,"year":2019},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/a-comparison-of-p-tau-assays-for-the-specificity-to-detect-tau-40289884","doi":"10.1002/alz.70208","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":668,"pmid":"40289884","source_url":"https://pubmed.ncbi.nlm.nih.gov/40289884/","study_design":null,"title":"A comparison of p-tau assays for the specificity to detect tau changes in Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/gastrodin-and-gastrodigenin-improve-energy-metabolism-disorders-and-36985572","doi":"10.3390/molecules28062598","journal":"Molecules (Basel, Switzerland)","n_participants":null,"pmid":"36985572","source_url":"https://pubmed.ncbi.nlm.nih.gov/36985572/","study_design":null,"title":"Gastrodin and Gastrodigenin Improve Energy Metabolism Disorders and Mitochondrial Dysfunction to Antagonize Vascular Dementia","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/population-pharmacokinetic-pharmacodynamic-analyses-of-amyloid-36165093","doi":"10.1002/psp4.12862","journal":"CPT: pharmacometrics & systems pharmacology","n_participants":null,"pmid":"36165093","source_url":"https://pubmed.ncbi.nlm.nih.gov/36165093/","study_design":null,"title":"Population pharmacokinetic-pharmacodynamic analyses of amyloid positron emission tomography and plasma biomarkers for lecanemab in subjects with early Alzheimer's disease","title_match":true,"year":2022},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/associating-alzheimer-s-disease-pathology-with-its-cerebrospinal-35026840","doi":"10.1093/brain/awac013","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"35026840","source_url":"https://pubmed.ncbi.nlm.nih.gov/35026840/","study_design":null,"title":"Associating Alzheimer's disease pathology with its cerebrospinal fluid biomarkers","title_match":false,"year":2022},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/concordance-of-csf-measures-of-alzheimer-s-pathology-with-amyloid-pet-33598527","doi":"10.1002/dad2.12131","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":63,"pmid":"33598527","source_url":"https://pubmed.ncbi.nlm.nih.gov/33598527/","study_design":null,"title":"Concordance of CSF measures of Alzheimer's pathology with amyloid PET status in a preclinical cohort: A comparison of Lumipulse and established immunoassays","title_match":false,"year":2021},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/tau-plasma-levels-in-subjective-cognitive-decline-results-from-the-28842559","doi":"10.1038/s41598-017-08779-0","journal":"Scientific reports","n_participants":null,"pmid":"28842559","source_url":"https://pubmed.ncbi.nlm.nih.gov/28842559/","study_design":"longitudinal study","title":"Tau plasma levels in subjective cognitive decline: Results from the DELCODE study","title_match":false,"year":2017},{"alzhub_score":83,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-biomarkers-in-cerebral-amyloid-angiopathy-new-35237145","doi":"10.3389/fnagi.2022.783996","journal":"Frontiers in aging neuroscience","n_participants":31,"pmid":"35237145","source_url":"https://pubmed.ncbi.nlm.nih.gov/35237145/","study_design":"meta-analysis","title":"Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy: New Data and Quantitative Meta-Analysis","title_match":false,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/association-of-apoe-4-and-plasma-p-tau181-with-preclinical-alzheimer-34924376","doi":"10.3233/jad-210673","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"34924376","source_url":"https://pubmed.ncbi.nlm.nih.gov/34924376/","study_design":"longitudinal study","title":"Association of APOE \u025b4 and Plasma p-tau181 with Preclinical Alzheimer's Disease and Longitudinal Change in Hippocampus Function","title_match":true,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-p-tau-lt-sub-gt-181-lt-sub-gt-shows-stronger-network-34854549","doi":"10.1002/alz.12508","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":235,"pmid":"34854549","source_url":"https://pubmed.ncbi.nlm.nih.gov/34854549/","study_design":null,"title":"Plasma p-tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau","title_match":true,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/novel-blood-based-proteomic-signatures-across-multiple-40145305","doi":"10.1002/alz.70116","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":36,"pmid":"40145305","source_url":"https://pubmed.ncbi.nlm.nih.gov/40145305/","study_design":null,"title":"Novel blood-based proteomic signatures across multiple neurodegenerative diseases","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/i-fusobacterium-nucleatum-i-infection-induced-neurodegeneration-and-36188448","doi":"10.3389/fnins.2022.884543","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"36188448","source_url":"https://pubmed.ncbi.nlm.nih.gov/36188448/","study_design":null,"title":"Fusobacterium nucleatum infection-induced neurodegeneration and abnormal gut microbiota composition in Alzheimer's disease-like rats","title_match":false,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/longitudinal-changes-in-brain-oxygen-extraction-fraction-oef-in-older-35791732","doi":"10.1002/alz.12727","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"35791732","source_url":"https://pubmed.ncbi.nlm.nih.gov/35791732/","study_design":"longitudinal study","title":"Longitudinal changes in brain oxygen extraction fraction (OEF) in older adults: Relationship to markers of vascular and Alzheimer's pathology","title_match":false,"year":2023},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/a-longitudinal-study-of-total-and-phosphorylated-synuclein-with-other-29376878","doi":"10.3233/jad-171013","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"29376878","source_url":"https://pubmed.ncbi.nlm.nih.gov/29376878/","study_design":"longitudinal study","title":"A Longitudinal Study of Total and Phosphorylated \u03b1-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment","title_match":false,"year":2018},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/biomarker-discovery-in-alzheimer-s-and-neurodegenerative-diseases-40401628","doi":"10.1002/alz.14621","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40401628","source_url":"https://pubmed.ncbi.nlm.nih.gov/40401628/","study_design":null,"title":"Biomarker discovery in Alzheimer's and neurodegenerative diseases using Nucleic Acid Linked Immuno-Sandwich Assay","title_match":false,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-of-amyloid-tau-axonal-and-neuroinflammation-38961441","doi":"10.1186/s13195-024-01502-y","journal":"Alzheimer's research & therapy","n_participants":104,"pmid":"38961441","source_url":"https://pubmed.ncbi.nlm.nih.gov/38961441/","study_design":null,"title":"Plasma biomarkers of amyloid, tau, axonal, and neuroinflammation pathologies in dementia with Lewy bodies","title_match":true,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/tau-pathology-is-associated-with-synaptic-density-and-longitudinal-38589563","doi":"10.1038/s41380-024-02501-z","journal":"Molecular psychiatry","n_participants":null,"pmid":"38589563","source_url":"https://pubmed.ncbi.nlm.nih.gov/38589563/","study_design":"cross-sectional","title":"Tau pathology is associated with synaptic density and longitudinal synaptic loss in Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/skeletal-muscle-mitochondrial-function-predicts-cognitive-impairment-37530130","doi":"10.1002/alz.13388","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37530130","source_url":"https://pubmed.ncbi.nlm.nih.gov/37530130/","study_design":null,"title":"Skeletal muscle mitochondrial function predicts cognitive impairment and is associated with biomarkers of Alzheimer's disease and neurodegeneration","title_match":false,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/autotaxin-is-related-to-metabolic-dysfunction-and-predicts-alzheimer-27911319","doi":"10.3233/jad-160891","journal":"Journal of Alzheimer's disease : JAD","n_participants":86,"pmid":"27911319","source_url":"https://pubmed.ncbi.nlm.nih.gov/27911319/","study_design":null,"title":"Autotaxin is Related to Metabolic Dysfunction and Predicts Alzheimer's Disease Outcomes","title_match":false,"year":2017},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/csf-beta-amyloid-1-42-what-are-we-measuring-in-alzheimer-s-disease-25750918","doi":"10.1002/acn3.160","journal":"Annals of clinical and translational neurology","n_participants":69,"pmid":"25750918","source_url":"https://pubmed.ncbi.nlm.nih.gov/25750918/","study_design":null,"title":"CSF beta-amyloid 1-42 - what are we measuring in Alzheimer's disease?","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/genetic-variants-of-gsk3b-are-associated-with-biomarkers-for-25420549","doi":"10.3233/jad-142025","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"25420549","source_url":"https://pubmed.ncbi.nlm.nih.gov/25420549/","study_design":null,"title":"Genetic variants of GSK3B are associated with biomarkers for Alzheimer's disease and cognitive function","title_match":false,"year":2015},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/p-tau217-and-other-blood-biomarkers-of-dementia-variation-with-time-39271655","doi":"10.1038/s41398-024-03084-7","journal":"Translational psychiatry","n_participants":38,"pmid":"39271655","source_url":"https://pubmed.ncbi.nlm.nih.gov/39271655/","study_design":null,"title":"P-tau217 and other blood biomarkers of dementia: variation with time of day","title_match":true,"year":2024},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/a-blood-based-biomarker-workflow-for-optimal-tau-pet-referral-in-38486040","doi":"10.1038/s41467-024-46603-2","journal":"Nature communications","n_participants":548,"pmid":"38486040","source_url":"https://pubmed.ncbi.nlm.nih.gov/38486040/","study_design":null,"title":"A blood-based biomarker workflow for optimal tau-PET referral in memory clinic settings","title_match":true,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/plasma-gfap-associates-with-secondary-alzheimer-s-pathology-in-lewy-37000892","doi":"10.1002/acn3.51768","journal":"Annals of clinical and translational neurology","n_participants":19,"pmid":"37000892","source_url":"https://pubmed.ncbi.nlm.nih.gov/37000892/","study_design":null,"title":"Plasma GFAP associates with secondary Alzheimer's pathology in Lewy body disease","title_match":true,"year":2023},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau181-predicts-cognitive-and-functional-decline-36518085","doi":"10.1002/acn3.51695","journal":"Annals of clinical and translational neurology","n_participants":91,"pmid":"36518085","source_url":"https://pubmed.ncbi.nlm.nih.gov/36518085/","study_design":null,"title":"Plasma phosphorylated tau181 predicts cognitive and functional decline","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/biochemical-neuropathological-and-neuroimaging-characteristics-of-21094210","doi":"10.1016/j.neulet.2010.10.039","journal":"Neuroscience letters","n_participants":null,"pmid":"21094210","source_url":"https://pubmed.ncbi.nlm.nih.gov/21094210/","study_design":null,"title":"Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation","title_match":false,"year":2011},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/blood-phosphorylated-tau217-distinguishes-amyloid-positive-from-40047958","doi":"10.1007/s00415-025-12996-3","journal":"Journal of neurology","n_participants":null,"pmid":"40047958","source_url":"https://pubmed.ncbi.nlm.nih.gov/40047958/","study_design":"systematic review","title":"Blood phosphorylated Tau217 distinguishes amyloid-positive from amyloid-negative subjects in the Alzheimer's disease continuum. A systematic review and meta-analysis","title_match":false,"year":2025},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/apoe4-impact-on-soluble-and-insoluble-tau-pathology-is-mostly-39817469","doi":"10.1093/brain/awaf016","journal":"Brain : a journal of neurology","n_participants":1370,"pmid":"39817469","source_url":"https://pubmed.ncbi.nlm.nih.gov/39817469/","study_design":"cross-sectional","title":"APOE4 impact on soluble and insoluble tau pathology is mostly influenced by amyloid-\u03b2","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-of-alzheimer-s-disease-in-the-community-variation-by-38717935","doi":"10.1002/alz.13860","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38717935","source_url":"https://pubmed.ncbi.nlm.nih.gov/38717935/","study_design":null,"title":"Blood biomarkers of Alzheimer's disease in the community: Variation by chronic diseases and inflammatory status","title_match":false,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/systematic-characterization-of-multi-omics-landscape-between-gut-38652661","doi":"10.1016/j.celrep.2024.114128","journal":"Cell reports","n_participants":null,"pmid":"38652661","source_url":"https://pubmed.ncbi.nlm.nih.gov/38652661/","study_design":null,"title":"Systematic characterization of multi-omics landscape between gut microbial metabolites and GPCRome in Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/sex-differences-in-blood-biomarkers-and-cognitive-performance-in-37279390","doi":"10.1002/alz.13314","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37279390","source_url":"https://pubmed.ncbi.nlm.nih.gov/37279390/","study_design":"cross-sectional","title":"Sex differences in blood biomarkers and cognitive performance in individuals with autosomal dominant Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/dissociable-contribution-of-plasma-nfl-and-p-tau181-to-cognitive-35752549","doi":"10.1016/j.parkreldis.2022.05.020","journal":"Parkinsonism & related disorders","n_participants":null,"pmid":"35752549","source_url":"https://pubmed.ncbi.nlm.nih.gov/35752549/","study_design":"prospective cohort","title":"Dissociable contribution of plasma NfL and p-tau181 to cognitive impairment in Parkinson's disease","title_match":true,"year":2022},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/blood-phosphorylated-tau-181-as-a-biomarker-for-amyloid-burden-on-35491781","doi":"10.3233/jad-215639","journal":"Journal of Alzheimer's disease : JAD","n_participants":18,"pmid":"35491781","source_url":"https://pubmed.ncbi.nlm.nih.gov/35491781/","study_design":null,"title":"Blood Phosphorylated Tau 181 as a Biomarker for Amyloid Burden on Brain PET in Cognitively Healthy Adults","title_match":false,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/cutting-through-the-noise-a-narrative-review-of-alzheimer-s-disease-39814656","doi":"10.1016/j.tjpad.2024.100056","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"39814656","source_url":"https://pubmed.ncbi.nlm.nih.gov/39814656/","study_design":null,"title":"Cutting through the noise: A narrative review of Alzheimer's disease plasma biomarkers for routine clinical use","title_match":true,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/metabotropic-glutamate-receptor-5-mglur5-is-associated-with-38217040","doi":"10.1186/s13195-024-01385-z","journal":"Alzheimer's research & therapy","n_participants":27,"pmid":"38217040","source_url":"https://pubmed.ncbi.nlm.nih.gov/38217040/","study_design":null,"title":"Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer's disease: A [18F]PSS232 PET/MRI study","title_match":false,"year":2024},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/risk-of-alzheimer-s-disease-is-associated-with-longitudinal-changes-38183363","doi":"10.1002/alz.13652","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38183363","source_url":"https://pubmed.ncbi.nlm.nih.gov/38183363/","study_design":"longitudinal study","title":"Risk of Alzheimer's disease is associated with longitudinal changes in plasma biomarkers in the multi-ethnic Washington Heights-Hamilton Heights-Inwood Columbia Aging Project (WHICAP) cohort","title_match":true,"year":2024},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/sensitive-label-free-detection-of-the-biomarker-phosphorylated-tau-36933321","doi":"10.1016/j.bios.2023.115174","journal":"Biosensors & bioelectronics","n_participants":null,"pmid":"36933321","source_url":"https://pubmed.ncbi.nlm.nih.gov/36933321/","study_design":null,"title":"Sensitive label-free detection of the biomarker phosphorylated tau-217 protein in Alzheimer's disease using a graphene-based solution-gated field effect transistor","title_match":false,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/evaluation-of-cerebrospinal-fluid-phosphorylated-tau-lt-sub-gt-231-lt-29453935","doi":"10.1111/cns.12814","journal":"CNS neuroscience & therapeutics","n_participants":198,"pmid":"29453935","source_url":"https://pubmed.ncbi.nlm.nih.gov/29453935/","study_design":null,"title":"Evaluation of cerebrospinal fluid phosphorylated tau231 as a biomarker in the differential diagnosis of Alzheimer's disease and vascular dementia","title_match":false,"year":2018},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/plasma-p-tau-lt-sub-gt-217-lt-sub-gt-and-neurofilament-p-tau-lt-sub-39776166","doi":"10.1002/alz.14482","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":374,"pmid":"39776166","source_url":"https://pubmed.ncbi.nlm.nih.gov/39776166/","study_design":"cohort study","title":"Plasma p-tau217 and neurofilament/p-tau217 ratio in differentiating Alzheimer's disease from syndromes associated with frontotemporal lobar degeneration","title_match":true,"year":2025},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/plasma-phospho-tau217-as-a-predictive-biomarker-for-alzheimer-s-39743558","doi":"10.1186/s13195-024-01655-w","journal":"Alzheimer's research & therapy","n_participants":234,"pmid":"39743558","source_url":"https://pubmed.ncbi.nlm.nih.gov/39743558/","study_design":null,"title":"Plasma phospho-tau217 as a predictive biomarker for Alzheimer's disease in a large south American cohort","title_match":false,"year":2025},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/clinical-application-of-plasma-p-tau217-to-assess-eligibility-for-38971815","doi":"10.1186/s13195-024-01521-9","journal":"Alzheimer's research & therapy","n_participants":150,"pmid":"38971815","source_url":"https://pubmed.ncbi.nlm.nih.gov/38971815/","study_design":"cohort study","title":"Clinical application of plasma P-tau217 to assess eligibility for amyloid-lowering immunotherapy in memory clinic patients with early Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/reference-intervals-for-plasma-amyloid-total-tau-and-phosphorylated-37237388","doi":"10.1186/s13195-023-01246-1","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"37237388","source_url":"https://pubmed.ncbi.nlm.nih.gov/37237388/","study_design":null,"title":"Reference intervals for plasma amyloid-\u03b2, total tau, and phosphorylated tau181 in healthy elderly Chinese individuals without cognitive impairment","title_match":true,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/modulating-heart-rate-oscillation-affects-plasma-amyloid-beta-and-tau-36894565","doi":"10.1038/s41598-023-30167-0","journal":"Scientific reports","n_participants":108,"pmid":"36894565","source_url":"https://pubmed.ncbi.nlm.nih.gov/36894565/","study_design":null,"title":"Modulating heart rate oscillation affects plasma amyloid beta and tau levels in younger and older adults","title_match":true,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-tau-neurodegeneration-biomarkers-and-inflammatory-36062146","doi":"10.3389/fnagi.2022.963845","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"36062146","source_url":"https://pubmed.ncbi.nlm.nih.gov/36062146/","study_design":null,"title":"Plasma \u03b2-amyloid, tau, neurodegeneration biomarkers and inflammatory factors of probable Alzheimer's disease dementia in Chinese individuals","title_match":false,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/low-levels-of-cerebrospinal-fluid-complement-3-and-factor-h-predict-25478014","doi":"10.1186/alzrt266","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"25478014","source_url":"https://pubmed.ncbi.nlm.nih.gov/25478014/","study_design":"longitudinal study","title":"Low levels of cerebrospinal fluid complement 3 and factor H predict faster cognitive decline in mild cognitive impairment","title_match":false,"year":2014},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/association-of-plasma-biomarkers-of-alzheimer-s-disease-and-related-38753951","doi":"10.1002/alz.13829","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":787,"pmid":"38753951","source_url":"https://pubmed.ncbi.nlm.nih.gov/38753951/","study_design":null,"title":"Association of plasma biomarkers of Alzheimer's disease and related disorders with cognition and cognitive decline: The MYHAT population-based study","title_match":true,"year":2024},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/associations-among-plasma-mri-and-amyloid-pet-biomarkers-of-alzheimer-38747525","doi":"10.1002/alz.13835","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":299,"pmid":"38747525","source_url":"https://pubmed.ncbi.nlm.nih.gov/38747525/","study_design":null,"title":"Associations among plasma, MRI, and amyloid PET biomarkers of Alzheimer's disease and related dementias and the impact of health-related comorbidities in a community-dwelling cohort","title_match":false,"year":2024},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/different-inflammatory-signatures-based-on-csf-biomarkers-relate-to-38216727","doi":"10.1038/s41380-023-02387-3","journal":"Molecular psychiatry","n_participants":295,"pmid":"38216727","source_url":"https://pubmed.ncbi.nlm.nih.gov/38216727/","study_design":"longitudinal study","title":"Different inflammatory signatures based on CSF biomarkers relate to preserved or diminished brain structure and cognition","title_match":false,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/assessment-of-plasma-and-cerebrospinal-fluid-biomarkers-in-different-36674742","doi":"10.3390/ijms24021226","journal":"International journal of molecular sciences","n_participants":22,"pmid":"36674742","source_url":"https://pubmed.ncbi.nlm.nih.gov/36674742/","study_design":null,"title":"Assessment of Plasma and Cerebrospinal Fluid Biomarkers in Different Stages of Alzheimer's Disease and Frontotemporal Dementia","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/csf-tau368-total-tau-ratio-reflects-cognitive-performance-and-36544221","doi":"10.1186/s13195-022-01142-0","journal":"Alzheimer's research & therapy","n_participants":125,"pmid":"36544221","source_url":"https://pubmed.ncbi.nlm.nih.gov/36544221/","study_design":null,"title":"CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired individuals","title_match":true,"year":2022},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/ante-mortem-plasma-phosphorylated-tau-181-predicts-alzheimer-s-35554506","doi":"10.1093/brain/awac175","journal":"Brain : a journal of neurology","n_participants":103,"pmid":"35554506","source_url":"https://pubmed.ncbi.nlm.nih.gov/35554506/","study_design":null,"title":"Ante-mortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy","title_match":false,"year":2022},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/comprehensive-evaluation-of-plasma-tau-biomarkers-for-detecting-and-40550877","doi":"10.1038/s43587-025-00904-3","journal":"Nature aging","n_participants":425,"pmid":"40550877","source_url":"https://pubmed.ncbi.nlm.nih.gov/40550877/","study_design":"cross-sectional","title":"Comprehensive evaluation of plasma tau biomarkers for detecting and monitoring Alzheimer's disease in a multicenter and multiethnic aging population","title_match":false,"year":2025},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/plasma-ptau217-ratio-predicts-continuous-regional-brain-tau-39575854","doi":"10.1002/alz.14411","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39575854","source_url":"https://pubmed.ncbi.nlm.nih.gov/39575854/","study_design":null,"title":"Plasma pTau217 ratio predicts continuous regional brain tau accumulation in amyloid-positive early Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/neuropathological-changes-associated-with-aberrant-cerebrospinal-38539238","doi":"10.1186/s40478-024-01758-3","journal":"Acta neuropathologica communications","n_participants":22,"pmid":"38539238","source_url":"https://pubmed.ncbi.nlm.nih.gov/38539238/","study_design":null,"title":"Neuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and A\u03b242 in Alzheimer's disease and other neurodegenerative diseases","title_match":true,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/plasma-p-tau181-as-a-promising-non-invasive-biomarker-of-alzheimer-s-37716237","doi":"10.1016/j.jns.2023.120805","journal":"Journal of the neurological sciences","n_participants":null,"pmid":"37716237","source_url":"https://pubmed.ncbi.nlm.nih.gov/37716237/","study_design":null,"title":"Plasma p-tau181 as a promising non-invasive biomarker of Alzheimer's Disease pathology in Subjective Cognitive Decline and Mild Cognitive Impairment","title_match":true,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/performance-of-plasma-a42-40-measured-using-a-fully-automated-37667408","doi":"10.1186/s13195-023-01296-5","journal":"Alzheimer's research & therapy","n_participants":174,"pmid":"37667408","source_url":"https://pubmed.ncbi.nlm.nih.gov/37667408/","study_design":null,"title":"Performance of plasma A\u03b242/40, measured using a fully automated immunoassay, across a broad patient population in identifying amyloid status","title_match":true,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/csf-ferritin-in-the-clinicopathological-progression-of-alzheimer-s-36357168","doi":"10.1136/jnnp-2022-330052","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"36357168","source_url":"https://pubmed.ncbi.nlm.nih.gov/36357168/","study_design":"longitudinal study","title":"CSF ferritin in the clinicopathological progression of Alzheimer's disease and associations with APOE and inflammation biomarkers","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-correlations-between-plasma-fibrinogen-with-amyloid-beta-and-tau-33551734","doi":"10.3389/fnins.2020.625844","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"33551734","source_url":"https://pubmed.ncbi.nlm.nih.gov/33551734/","study_design":null,"title":"The Correlations Between Plasma Fibrinogen With Amyloid-Beta and Tau Levels in Patients With Alzheimer's Disease","title_match":false,"year":2020},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/comparing-atn-t-designation-by-tau-pet-visual-reads-tau-pet-33398408","doi":"10.1007/s00259-020-05152-8","journal":"European journal of nuclear medicine and molecular imaging","n_participants":351,"pmid":"33398408","source_url":"https://pubmed.ncbi.nlm.nih.gov/33398408/","study_design":null,"title":"Comparing ATN-T designation by tau PET visual reads, tau PET quantification, and CSF PTau181 across three cohorts","title_match":true,"year":2021},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/sleep-spindles-and-slow-oscillations-predict-cognition-and-biomarkers-39878233","doi":"10.1002/alz.14424","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":60,"pmid":"39878233","source_url":"https://pubmed.ncbi.nlm.nih.gov/39878233/","study_design":"prospective cohort","title":"Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/clinical-utility-of-plasma-p-tau217-in-identifying-abnormal-brain-39807654","doi":"10.1002/alz.14502","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":142,"pmid":"39807654","source_url":"https://pubmed.ncbi.nlm.nih.gov/39807654/","study_design":null,"title":"Clinical utility of plasma p-tau217 in identifying abnormal brain amyloid burden in an Asian cohort with high prevalence of concomitant cerebrovascular disease","title_match":true,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/serum-neurofilament-light-chain-and-inflammatory-cytokines-as-38643230","doi":"10.1038/s41598-024-59530-5","journal":"Scientific reports","n_participants":null,"pmid":"38643230","source_url":"https://pubmed.ncbi.nlm.nih.gov/38643230/","study_design":"cross-sectional","title":"Serum neurofilament light chain and inflammatory cytokines as biomarkers for early detection of mild cognitive impairment","title_match":false,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/elevated-plasma-sclerostin-is-associated-with-high-brain-amyloid-load-37666862","doi":"10.1038/s41514-023-00114-4","journal":"npj aging","n_participants":65,"pmid":"37666862","source_url":"https://pubmed.ncbi.nlm.nih.gov/37666862/","study_design":null,"title":"Elevated plasma sclerostin is associated with high brain amyloid-\u03b2 load in cognitively normal older adults","title_match":false,"year":2023},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/sex-differences-in-alzheimer-s-disease-plasma-mmp-9-and-markers-of-36324151","doi":"10.1186/s13195-022-01106-4","journal":"Alzheimer's research & therapy","n_participants":238,"pmid":"36324151","source_url":"https://pubmed.ncbi.nlm.nih.gov/36324151/","study_design":"longitudinal study","title":"Sex differences in Alzheimer's disease: plasma MMP-9 and markers of disease severity","title_match":false,"year":2022},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/does-csf-p-tau181-help-to-discriminate-alzheimer-s-disease-from-other-24817210","doi":"10.1007/s00702-014-1226-y","journal":"Journal of neural transmission (Vienna, Austria : 1996)","n_participants":null,"pmid":"24817210","source_url":"https://pubmed.ncbi.nlm.nih.gov/24817210/","study_design":"meta-analysis","title":"Does CSF p-tau181 help to discriminate Alzheimer's disease from other dementias and mild cognitive impairment? A meta-analysis of the literature","title_match":true,"year":2014},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/a-minimally-invasive-dried-blood-spot-biomarker-test-for-the-41491101","doi":"10.1038/s41591-025-04080-0","journal":"Nature medicine","n_participants":337,"pmid":"41491101","source_url":"https://pubmed.ncbi.nlm.nih.gov/41491101/","study_design":null,"title":"A minimally invasive dried blood spot biomarker test for the detection of Alzheimer's disease pathology","title_match":false,"year":2026},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/association-of-microplastics-in-human-cerebrospinal-fluid-with-40435616","doi":"10.1016/j.jhazmat.2025.138748","journal":"Journal of hazardous materials","n_participants":null,"pmid":"40435616","source_url":"https://pubmed.ncbi.nlm.nih.gov/40435616/","study_design":null,"title":"Association of microplastics in human cerebrospinal fluid with Alzheimer's disease-related changes","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/tau-seeds-from-alzheimer-s-disease-brains-trigger-tau-spread-in-38148705","doi":"10.1002/alz.13604","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38148705","source_url":"https://pubmed.ncbi.nlm.nih.gov/38148705/","study_design":null,"title":"Tau seeds from Alzheimer's disease brains trigger tau spread in macaques while oligomeric-A\u03b2 mediates pathology maturation","title_match":false,"year":2024},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/microglial-activation-tau-pathology-and-neurodegeneration-biomarkers-35847667","doi":"10.3389/fnagi.2022.848180","journal":"Frontiers in aging neuroscience","n_participants":430,"pmid":"35847667","source_url":"https://pubmed.ncbi.nlm.nih.gov/35847667/","study_design":"longitudinal study","title":"Microglial Activation, Tau Pathology, and Neurodegeneration Biomarkers Predict Longitudinal Cognitive Decline in Alzheimer's Disease Continuum","title_match":false,"year":2022},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/objective-subtle-cognitive-decline-and-plasma-phosphorylated-tau181-34692978","doi":"10.1002/dad2.12238","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":402,"pmid":"34692978","source_url":"https://pubmed.ncbi.nlm.nih.gov/34692978/","study_design":"longitudinal study","title":"Objective subtle cognitive decline and plasma phosphorylated tau181: Early markers of Alzheimer's disease-related declines","title_match":false,"year":2021},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/synergistic-association-between-plasma-a-lt-sub-gt-1-42-lt-sub-gt-and-33825443","doi":"10.1021/acschemneuro.1c00010","journal":"ACS chemical neuroscience","n_participants":62,"pmid":"33825443","source_url":"https://pubmed.ncbi.nlm.nih.gov/33825443/","study_design":null,"title":"Synergistic Association between Plasma A\u03b21-42 and p-tau in Alzheimer's Disease but Not in Parkinson's Disease or Frontotemporal Dementia","title_match":true,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/effects-of-certain-pre-analytical-factors-on-the-performance-of-38331843","doi":"10.1186/s13195-024-01391-1","journal":"Alzheimer's research & therapy","n_participants":50,"pmid":"38331843","source_url":"https://pubmed.ncbi.nlm.nih.gov/38331843/","study_design":null,"title":"Effects of certain pre-analytical factors on the performance of plasma phospho-tau217","title_match":false,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/tryptophan-metabolism-and-neurodegeneration-longitudinal-associations-36565121","doi":"10.3233/jad-220906","journal":"Journal of Alzheimer's disease : JAD","n_participants":301,"pmid":"36565121","source_url":"https://pubmed.ncbi.nlm.nih.gov/36565121/","study_design":null,"title":"Tryptophan Metabolism and Neurodegeneration: Longitudinal Associations of Kynurenine Pathway Metabolites with Cognitive Performance and Plasma Alzheimer's Disease and Related Dementias Biomarkers in the Duke Physical Performance Across the LifeSpan Study","title_match":false,"year":2023},{"alzhub_score":78,"alzhub_url":"https://alzhub.org/study/plasma-tau-proteins-for-the-diagnosis-of-mild-cognitive-impairment-35959295","doi":"10.3389/fnagi.2022.942629","journal":"Frontiers in aging neuroscience","n_participants":56,"pmid":"35959295","source_url":"https://pubmed.ncbi.nlm.nih.gov/35959295/","study_design":"systematic review","title":"Plasma tau proteins for the diagnosis of mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis","title_match":false,"year":2022},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/the-csf-p-tau181-a42-ratio-offers-a-good-accuracy-in-vivo-in-the-31345148","doi":"10.2174/1567205016666190725150836","journal":"Current Alzheimer research","n_participants":526,"pmid":"31345148","source_url":"https://pubmed.ncbi.nlm.nih.gov/31345148/","study_design":null,"title":"The CSF p-tau181/A\u03b242 Ratio Offers a Good Accuracy \"In Vivo\" in the Differential Diagnosis of Alzheimer's Dementia","title_match":true,"year":2019},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/pharmacologic-reversal-of-advanced-alzheimer-s-disease-in-mice-and-41435831","doi":"10.1016/j.xcrm.2025.102535","journal":"Cell reports. Medicine","n_participants":null,"pmid":"41435831","source_url":"https://pubmed.ncbi.nlm.nih.gov/41435831/","study_design":null,"title":"Pharmacologic reversal of advanced Alzheimer's disease in mice and identification of potential therapeutic nodes in human brain","title_match":false,"year":2026},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/evaluation-of-plasma-p-tau217-for-detecting-amyloid-pathology-in-a-40613474","doi":"10.1002/alz.70426","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":598,"pmid":"40613474","source_url":"https://pubmed.ncbi.nlm.nih.gov/40613474/","study_design":null,"title":"Evaluation of plasma p-tau217 for detecting amyloid pathology in a heterogeneous community-based cohort","title_match":true,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/diagnostic-performance-of-plasma-p-tau217-in-a-memory-clinic-cohort-40140924","doi":"10.1186/s13195-025-01719-5","journal":"Alzheimer's research & therapy","n_participants":493,"pmid":"40140924","source_url":"https://pubmed.ncbi.nlm.nih.gov/40140924/","study_design":null,"title":"Diagnostic performance of plasma p-tau217 in a memory clinic cohort using the Lumipulse automated platform","title_match":true,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/relationship-between-plasma-p-tau217-and-amyloid-pet-in-racial-and-39044491","doi":"10.14283/jpad.2024.124","journal":"The journal of prevention of Alzheimer's disease","n_participants":1018,"pmid":"39044491","source_url":"https://pubmed.ncbi.nlm.nih.gov/39044491/","study_design":null,"title":"Relationship between Plasma P-Tau217 and Amyloid PET in Racial and Ethnic Underrepresented Groups (RE-URG) Compared with Non RE-URG in LEARN and A4","title_match":true,"year":2024},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/neuropsychiatric-symptoms-in-alzheimer-s-continuum-and-their-38159651","doi":"10.1016/j.jad.2023.12.062","journal":"Journal of affective disorders","n_participants":53,"pmid":"38159651","source_url":"https://pubmed.ncbi.nlm.nih.gov/38159651/","study_design":"cross-sectional","title":"Neuropsychiatric symptoms in Alzheimer's continuum and their association with plasma biomarkers","title_match":true,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/levels-of-plasma-brain-derived-tau-and-p-tau181-in-alzheimer-s-37858957","doi":"10.1002/alz.13516","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37858957","source_url":"https://pubmed.ncbi.nlm.nih.gov/37858957/","study_design":null,"title":"Levels of plasma brain-derived tau and p-tau181 in Alzheimer's disease and rapidly progressive dementias","title_match":true,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/dysregulation-of-ruminococcaceae-and-megamonas-could-be-predictive-37543169","doi":"10.1016/j.micpath.2023.106272","journal":"Microbial pathogenesis","n_participants":1013,"pmid":"37543169","source_url":"https://pubmed.ncbi.nlm.nih.gov/37543169/","study_design":null,"title":"Dysregulation of Ruminococcaceae and Megamonas could be predictive markers for rapid progression of mild cognitive impairment","title_match":false,"year":2023},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-diagnostic-accuracy-by-fluid-and-neuroimaging-atn-37438991","doi":"10.1111/cns.14357","journal":"CNS neuroscience & therapeutics","n_participants":2340,"pmid":"37438991","source_url":"https://pubmed.ncbi.nlm.nih.gov/37438991/","study_design":"longitudinal study","title":"Alzheimer's disease diagnostic accuracy by fluid and neuroimaging ATN framework","title_match":false,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/head-to-head-comparison-of-plasma-and-pet-imaging-atn-markers-in-37381042","doi":"10.1186/s40035-023-00365-x","journal":"Translational neurodegeneration","n_participants":137,"pmid":"37381042","source_url":"https://pubmed.ncbi.nlm.nih.gov/37381042/","study_design":null,"title":"Head-to-head comparison of plasma and PET imaging ATN markers in subjects with cognitive complaints","title_match":false,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/the-relationship-of-insulin-resistance-and-diabetes-to-tau-pet-suvr-36932429","doi":"10.1186/s13195-023-01180-2","journal":"Alzheimer's research & therapy","n_participants":280,"pmid":"36932429","source_url":"https://pubmed.ncbi.nlm.nih.gov/36932429/","study_design":null,"title":"The relationship of insulin resistance and diabetes to tau PET SUVR in middle-aged to older adults","title_match":false,"year":2023},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/the-tas-test-project-a-prospective-longitudinal-validation-of-new-35850660","doi":"10.1186/s12883-022-02772-5","journal":"BMC neurology","n_participants":300,"pmid":"35850660","source_url":"https://pubmed.ncbi.nlm.nih.gov/35850660/","study_design":"cohort study","title":"The TAS Test project: a prospective longitudinal validation of new online motor-cognitive tests to detect preclinical Alzheimer's disease and estimate 5-year risks of cognitive decline and dementia","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/neurodegenerative-disease-biomarkers-a-lt-sub-gt-1-40-lt-sub-gt-a-lt-29484263","doi":"10.1002/brb3.903","journal":"Brain and behavior","n_participants":null,"pmid":"29484263","source_url":"https://pubmed.ncbi.nlm.nih.gov/29484263/","study_design":null,"title":"Neurodegenerative disease biomarkers A\u03b21-40, A\u03b21-42, tau, and p-tau181 in the vervet monkey cerebrospinal fluid: Relation to normal aging, genetic influences, and cerebral amyloid angiopathy","title_match":false,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/protein-signature-in-cerebrospinal-fluid-and-serum-of-alzheimer-s-28628634","doi":"10.1371/journal.pone.0179280","journal":"PloS one","n_participants":null,"pmid":"28628634","source_url":"https://pubmed.ncbi.nlm.nih.gov/28628634/","study_design":null,"title":"Protein signature in cerebrospinal fluid and serum of Alzheimer's disease patients: The case of apolipoprotein A-1 proteoforms","title_match":false,"year":2017},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/accuracy-and-clinical-applicability-of-plasma-tau-181-and-217-for-39849125","doi":"10.1007/s00415-025-12897-5","journal":"Journal of neurology","n_participants":468,"pmid":"39849125","source_url":"https://pubmed.ncbi.nlm.nih.gov/39849125/","study_design":null,"title":"Accuracy and clinical applicability of plasma tau 181 and 217 for Alzheimer's disease diagnosis in a memory clinic cohort","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/association-and-multimodal-model-of-retinal-and-blood-based-39794837","doi":"10.1186/s13195-024-01668-5","journal":"Alzheimer's research & therapy","n_participants":82,"pmid":"39794837","source_url":"https://pubmed.ncbi.nlm.nih.gov/39794837/","study_design":null,"title":"Association and multimodal model of retinal and blood-based biomarkers for detection of preclinical Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/clinical-value-of-novel-blood-based-tau-biomarkers-in-creutzfeldt-39641397","doi":"10.1002/alz.14422","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39641397","source_url":"https://pubmed.ncbi.nlm.nih.gov/39641397/","study_design":null,"title":"Clinical value of novel blood-based tau biomarkers in Creutzfeldt-Jakob disease","title_match":false,"year":2025},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/mitochondrial-dna-abundance-in-blood-is-associated-with-alzheimer-s-39009700","doi":"10.1038/s41380-024-02670-x","journal":"Molecular psychiatry","n_participants":790,"pmid":"39009700","source_url":"https://pubmed.ncbi.nlm.nih.gov/39009700/","study_design":"cohort study","title":"Mitochondrial DNA abundance in blood is associated with Alzheimer's disease- and dementia-risk","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/comparison-of-plasma-and-neuroimaging-biomarkers-to-predict-cognitive-38755703","doi":"10.1186/s13195-024-01478-9","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"38755703","source_url":"https://pubmed.ncbi.nlm.nih.gov/38755703/","study_design":null,"title":"Comparison of plasma and neuroimaging biomarkers to predict cognitive decline in non-demented memory clinic patients","title_match":false,"year":2024},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/personalized-whole-brain-neural-mass-models-reveal-combined-a-and-tau-38704445","doi":"10.1038/s42003-024-06217-2","journal":"Communications biology","n_participants":132,"pmid":"38704445","source_url":"https://pubmed.ncbi.nlm.nih.gov/38704445/","study_design":null,"title":"Personalized whole-brain neural mass models reveal combined A\u03b2 and tau hyperexcitable influences in Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/the-impact-of-kidney-function-on-plasma-neurofilament-light-and-38347655","doi":"10.1186/s13195-024-01401-2","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"38347655","source_url":"https://pubmed.ncbi.nlm.nih.gov/38347655/","study_design":null,"title":"The impact of kidney function on plasma neurofilament light and phospho-tau 181 in a community-based cohort: the Shanghai Aging Study","title_match":false,"year":2024},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/construction-of-a-microcavity-based-microfluidic-chip-with-37201340","doi":"10.1016/j.talanta.2023.124677","journal":"Talanta","n_participants":null,"pmid":"37201340","source_url":"https://pubmed.ncbi.nlm.nih.gov/37201340/","study_design":null,"title":"Construction of a microcavity-based microfluidic chip with simultaneous SERS quantification of dual biomarkers for early diagnosis of Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/integrated-algorithm-combining-plasma-biomarkers-and-cognitive-37165172","doi":"10.1038/s43856-023-00295-9","journal":"Communications medicine","n_participants":609,"pmid":"37165172","source_url":"https://pubmed.ncbi.nlm.nih.gov/37165172/","study_design":null,"title":"Integrated algorithm combining plasma biomarkers and cognitive assessments accurately predicts brain \u03b2-amyloid pathology","title_match":true,"year":2023},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/potential-utility-of-plasma-p-tau-and-neurofilament-light-chain-as-36878697","doi":"10.1212/wnl.0000000000207115","journal":"Neurology","n_participants":257,"pmid":"36878697","source_url":"https://pubmed.ncbi.nlm.nih.gov/36878697/","study_design":"longitudinal study","title":"Potential Utility of Plasma P-Tau and Neurofilament Light Chain as Surrogate Biomarkers for Preventive Clinical Trials","title_match":true,"year":2023},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-for-the-diagnosis-of-neurodegenerative-dementia-a-36423207","doi":"10.1177/08919887221141651","journal":"Journal of geriatric psychiatry and neurology","n_participants":null,"pmid":"36423207","source_url":"https://pubmed.ncbi.nlm.nih.gov/36423207/","study_design":"systematic review","title":"Blood Biomarkers for the Diagnosis of Neurodegenerative Dementia: A Systematic Review","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/clinical-utility-of-cerebrospinal-fluid-biomarkers-measured-by-36321325","doi":"10.1002/acn3.51681","journal":"Annals of clinical and translational neurology","n_participants":null,"pmid":"36321325","source_url":"https://pubmed.ncbi.nlm.nih.gov/36321325/","study_design":null,"title":"Clinical utility of cerebrospinal fluid biomarkers measured by LUMIPULSE\u00ae system","title_match":false,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/sex-differences-in-risk-factors-that-predict-progression-from-mild-35968841","doi":"10.1017/s1355617722000297","journal":"Journal of the International Neuropsychological Society : JINS","n_participants":449,"pmid":"35968841","source_url":"https://pubmed.ncbi.nlm.nih.gov/35968841/","study_design":null,"title":"Sex differences in risk factors that predict progression from mild cognitive impairment to Alzheimer's dementia","title_match":false,"year":2023},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/development-of-a-biosensor-for-phosphorylated-tau-181-protein-35078121","doi":"10.1016/j.bioelechem.2022.108057","journal":"Bioelectrochemistry (Amsterdam, Netherlands)","n_participants":null,"pmid":"35078121","source_url":"https://pubmed.ncbi.nlm.nih.gov/35078121/","study_design":null,"title":"Development of a biosensor for phosphorylated Tau 181 protein detection in Early-Stage Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/abundance-of-nef-and-p-tau217-in-brains-of-individuals-diagnosed-with-34843091","doi":"10.1007/s12035-021-02608-2","journal":"Molecular neurobiology","n_participants":null,"pmid":"34843091","source_url":"https://pubmed.ncbi.nlm.nih.gov/34843091/","study_design":null,"title":"Abundance of Nef and p-Tau217 in Brains of Individuals Diagnosed with HIV-Associated Neurocognitive Disorders Correlate with Disease Severance","title_match":true,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/neuropathology-neuroimaging-and-fluid-biomarkers-in-alzheimer-s-38611617","doi":"10.3390/diagnostics14070704","journal":"Diagnostics (Basel, Switzerland)","n_participants":null,"pmid":"38611617","source_url":"https://pubmed.ncbi.nlm.nih.gov/38611617/","study_design":null,"title":"Neuropathology, Neuroimaging, and Fluid Biomarkers in Alzheimer's Disease","title_match":false,"year":2024},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/validation-of-a-prototype-tau-thr231-phosphorylation-csf-elisa-as-a-30767082","doi":"10.1007/s00702-019-01982-5","journal":"Journal of neural transmission (Vienna, Austria : 1996)","n_participants":null,"pmid":"30767082","source_url":"https://pubmed.ncbi.nlm.nih.gov/30767082/","study_design":null,"title":"Validation of a prototype tau Thr231 phosphorylation CSF ELISA as a potential biomarker for Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-proteomic-profiles-of-cerebrospinal-fluid-defined-alzheimer-s-29125490","doi":"10.3233/jad-170426","journal":"Journal of Alzheimer's disease : JAD","n_participants":72,"pmid":"29125490","source_url":"https://pubmed.ncbi.nlm.nih.gov/29125490/","study_design":"cross-sectional","title":"Plasma Proteomic Profiles of Cerebrospinal Fluid-Defined Alzheimer's Disease Pathology in Older Adults","title_match":false,"year":2017},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/increased-cerebrospinal-fluid-calpain-activity-and-microparticle-25200336","doi":"10.1016/j.jalz.2014.06.003","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":64,"pmid":"25200336","source_url":"https://pubmed.ncbi.nlm.nih.gov/25200336/","study_design":null,"title":"Increased cerebrospinal fluid calpain activity and microparticle levels in Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/progressive-myoclonus-epilepsy-in-down-syndrome-patients-with-dementia-24893590","doi":"10.1007/s00415-014-7376-x","journal":"Journal of neurology","n_participants":null,"pmid":"24893590","source_url":"https://pubmed.ncbi.nlm.nih.gov/24893590/","study_design":null,"title":"Progressive myoclonus epilepsy in Down syndrome patients with dementia","title_match":false,"year":2014},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/equivalence-of-plasma-and-serum-for-clinical-measurement-of-p-tau217-40600294","doi":"10.1111/jnc.70114","journal":"Journal of neurochemistry","n_participants":50,"pmid":"40600294","source_url":"https://pubmed.ncbi.nlm.nih.gov/40600294/","study_design":null,"title":"Equivalence of Plasma and Serum for Clinical Measurement of p-tau217: Comparative Analyses of Four Blood-Based Assays","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/cut-points-and-gray-zones-the-challenges-of-integrating-alzheimer-s-40145267","doi":"10.1002/alz.70113","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40145267","source_url":"https://pubmed.ncbi.nlm.nih.gov/40145267/","study_design":null,"title":"Cut-points and gray zones: The challenges of integrating Alzheimer's disease plasma biomarkers into clinical practice","title_match":true,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/influence-of-cognitive-impairment-and-race-on-plasma-p-tau-lt-sub-gt-39988568","doi":"10.1002/alz.14585","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":113,"pmid":"39988568","source_url":"https://pubmed.ncbi.nlm.nih.gov/39988568/","study_design":null,"title":"Influence of cognitive impairment and race on plasma p-Tau217 in two diverse cohorts","title_match":true,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/development-of-thresholds-and-a-visualization-tool-for-use-of-a-blood-39096164","doi":"10.1002/alz.14088","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":1199,"pmid":"39096164","source_url":"https://pubmed.ncbi.nlm.nih.gov/39096164/","study_design":null,"title":"Development of thresholds and a visualization tool for use of a blood test in routine clinical dementia practice","title_match":true,"year":2024},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/the-impact-of-exercise-on-blood-based-biomarkers-of-alzheimer-s-38488949","doi":"10.1007/s11357-024-01130-2","journal":"GeroScience","n_participants":null,"pmid":"38488949","source_url":"https://pubmed.ncbi.nlm.nih.gov/38488949/","study_design":null,"title":"The impact of exercise on blood-based biomarkers of Alzheimer's disease in cognitively unimpaired older adults","title_match":true,"year":2024},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/the-associations-of-phosphorylated-tau-181-and-tau-231-levels-in-38339929","doi":"10.3233/jad-230799","journal":"Journal of Alzheimer's disease : JAD","n_participants":5017,"pmid":"38339929","source_url":"https://pubmed.ncbi.nlm.nih.gov/38339929/","study_design":null,"title":"The Associations of Phosphorylated Tau 181 and Tau 231 Levels in Plasma and Cerebrospinal Fluid with Cognitive Function in Alzheimer's Disease: A Systematic Review and Meta-Analysis","title_match":false,"year":2024},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/associations-of-plasma-phosphorylated-tau181-and-neurofilament-light-36074638","doi":"10.1111/cns.13962","journal":"CNS neuroscience & therapeutics","n_participants":234,"pmid":"36074638","source_url":"https://pubmed.ncbi.nlm.nih.gov/36074638/","study_design":null,"title":"Associations of plasma phosphorylated tau181 and neurofilament light chain with brain amyloid burden and cognition in objectively defined subtle cognitive decline patients","title_match":false,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-ev-concentration-and-size-are-altered-in-35159272","doi":"10.3390/cells11030462","journal":"Cells","n_participants":120,"pmid":"35159272","source_url":"https://pubmed.ncbi.nlm.nih.gov/35159272/","study_design":null,"title":"Cerebrospinal Fluid EV Concentration and Size Are Altered in Alzheimer's Disease and Dementia with Lewy Bodies","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/serum-neurofilament-light-chain-as-a-surrogate-of-cognitive-decline-34375485","doi":"10.1111/ene.15058","journal":"European journal of neurology","n_participants":null,"pmid":"34375485","source_url":"https://pubmed.ncbi.nlm.nih.gov/34375485/","study_design":null,"title":"Serum neurofilament light chain as a surrogate of cognitive decline in sporadic and familial frontotemporal dementia","title_match":false,"year":2022},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/plasma-levels-of-phosphorylated-tau-181-are-associated-with-cerebral-33959711","doi":"10.1093/braincomms/fcab073","journal":"Brain communications","n_participants":389,"pmid":"33959711","source_url":"https://pubmed.ncbi.nlm.nih.gov/33959711/","study_design":"cross-sectional","title":"Plasma levels of phosphorylated tau 181 are associated with cerebral metabolic dysfunction in cognitively impaired and amyloid-positive individuals","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-fatty-acid-binding-protein-3-is-related-to-26484922","doi":"10.3233/jad-150525","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"26484922","source_url":"https://pubmed.ncbi.nlm.nih.gov/26484922/","study_design":null,"title":"Cerebrospinal Fluid Fatty Acid-Binding Protein 3 is Related to Dementia Development in a Population-Based Sample of Older Adult Women Followed for 8 Years","title_match":false,"year":2016},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/validation-of-elisa-methods-for-quantification-of-total-tau-and-21694458","doi":"10.3233/jad-2011-110296","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"21694458","source_url":"https://pubmed.ncbi.nlm.nih.gov/21694458/","study_design":"clinical trial","title":"Validation of ELISA methods for quantification of total tau and phosporylated-tau181 in human cerebrospinal fluid with measurement in specimens from two Alzheimer's disease studies","title_match":false,"year":2011},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/synaptic-loss-pattern-is-constrained-by-brain-connectome-and-40640137","doi":"10.1038/s41467-025-61497-4","journal":"Nature communications","n_participants":null,"pmid":"40640137","source_url":"https://pubmed.ncbi.nlm.nih.gov/40640137/","study_design":null,"title":"Synaptic loss pattern is constrained by brain connectome and modulated by phosphorylated tau in Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/differences-in-alzheimer-s-disease-blood-biomarker-stability-40308118","doi":"10.1002/alz.70173","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40308118","source_url":"https://pubmed.ncbi.nlm.nih.gov/40308118/","study_design":null,"title":"Differences in Alzheimer's disease blood biomarker stability: Implications for the use of tau/amyloid ratios","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-differentiate-ad-related-versus-non-ad-related-40110626","doi":"10.1002/alz.14619","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":648,"pmid":"40110626","source_url":"https://pubmed.ncbi.nlm.nih.gov/40110626/","study_design":null,"title":"Blood biomarkers differentiate AD-related versus non-AD-related cognitive deficits","title_match":false,"year":2025},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/comparison-of-plasma-p-tau217-and-p-tau181-in-predicting-amyloid-40044785","doi":"10.1038/s41598-025-90232-8","journal":"Scientific reports","n_participants":121,"pmid":"40044785","source_url":"https://pubmed.ncbi.nlm.nih.gov/40044785/","study_design":null,"title":"Comparison of plasma p-tau217 and p-tau181 in predicting amyloid positivity and prognosis among Korean memory clinic patients","title_match":true,"year":2025},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/cross-cultural-validation-of-plasma-p-tau217-and-p-tau181-as-39877979","doi":"10.1002/alz.14565","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":270,"pmid":"39877979","source_url":"https://pubmed.ncbi.nlm.nih.gov/39877979/","study_design":null,"title":"Cross-cultural validation of plasma p-tau217 and p-tau181 as precision biomarkers for amyloid PET positivity: An East Asian study in Taiwan and Korea","title_match":true,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/longitudinal-changes-in-the-functional-connectivity-of-individuals-at-38172488","doi":"10.1007/s11357-023-01036-5","journal":"GeroScience","n_participants":null,"pmid":"38172488","source_url":"https://pubmed.ncbi.nlm.nih.gov/38172488/","study_design":"cross-sectional","title":"Longitudinal changes in the functional connectivity of individuals at risk of Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/inhibition-of-asparagine-endopeptidase-aep-effectively-treats-38030711","doi":"10.1038/s41386-023-01774-2","journal":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","n_participants":null,"pmid":"38030711","source_url":"https://pubmed.ncbi.nlm.nih.gov/38030711/","study_design":null,"title":"Inhibition of asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer's disease in mice","title_match":false,"year":2024},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/predicting-cognitive-stage-transition-using-p-tau181-centiloid-and-36988152","doi":"10.1002/alz.13054","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"36988152","source_url":"https://pubmed.ncbi.nlm.nih.gov/36988152/","study_design":null,"title":"Predicting cognitive stage transition using p-tau181, Centiloid, and other measures","title_match":true,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/regional-white-matter-hyperintensities-and-alzheimer-s-disease-36744337","doi":"10.3233/jad-220846","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"36744337","source_url":"https://pubmed.ncbi.nlm.nih.gov/36744337/","study_design":"cross-sectional","title":"Regional White Matter Hyperintensities and Alzheimer's Disease Biomarkers Among Older Adults with Normal Cognition and Mild Cognitive Impairment","title_match":false,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/systematic-evaluation-of-urinary-formic-acid-as-a-new-potential-36533170","doi":"10.3389/fnagi.2022.1046066","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"36533170","source_url":"https://pubmed.ncbi.nlm.nih.gov/36533170/","study_design":null,"title":"Systematic evaluation of urinary formic acid as a new potential biomarker for Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/impaired-glymphatic-clearance-measured-using-diffusion-tensor-image-40776573","doi":"10.1002/mds.30325","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":null,"pmid":"40776573","source_url":"https://pubmed.ncbi.nlm.nih.gov/40776573/","study_design":"longitudinal study","title":"Impaired Glymphatic Clearance, Measured Using Diffusion Tensor Image Analysis Along the Perivascular Space (DTI-ALPS), is Linked to Poor Cognitive Outcomes in Parkinson's Disease","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/white-matter-injury-plasma-alzheimer-s-disease-and-neurodegenerative-39935410","doi":"10.1002/alz.14594","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":262,"pmid":"39935410","source_url":"https://pubmed.ncbi.nlm.nih.gov/39935410/","study_design":null,"title":"White matter injury, plasma Alzheimer's disease, and neurodegenerative biomarkers on cognitive decline in community-dwelling older adults: A 10-year longitudinal study","title_match":false,"year":2025},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/diagnostic-accuracy-of-plasma-p-tau217-for-detecting-pathological-39559871","doi":"10.14283/jpad.2024.152","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"39559871","source_url":"https://pubmed.ncbi.nlm.nih.gov/39559871/","study_design":"prospective cohort","title":"Diagnostic Accuracy of Plasma p-tau217 for Detecting Pathological Cerebrospinal Fluid Changes in Cognitively Unimpaired Subjects Using the Lumipulse Platform","title_match":true,"year":2024},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/association-between-blood-based-protein-biomarkers-and-brain-mri-in-39264441","doi":"10.1007/s00415-024-12674-w","journal":"Journal of neurology","n_participants":33,"pmid":"39264441","source_url":"https://pubmed.ncbi.nlm.nih.gov/39264441/","study_design":"systematic review","title":"Association between blood-based protein biomarkers and brain MRI in the Alzheimer's disease continuum: a systematic review","title_match":false,"year":2024},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/plasma-ptau181-and-ptau217-predict-asymptomatic-amyloid-accumulation-39051027","doi":"10.1093/braincomms/fcae162","journal":"Brain communications","n_participants":75,"pmid":"39051027","source_url":"https://pubmed.ncbi.nlm.nih.gov/39051027/","study_design":"cohort study","title":"Plasma pTau181 and pTau217 predict asymptomatic amyloid accumulation equally well as amyloid PET","title_match":true,"year":2024},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-for-alzheimer-s-disease-and-cognitive-function-38126555","doi":"10.1002/alz.13583","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":192,"pmid":"38126555","source_url":"https://pubmed.ncbi.nlm.nih.gov/38126555/","study_design":"longitudinal study","title":"Blood-based biomarkers for Alzheimer's disease and cognitive function from mid- to late life","title_match":true,"year":2024},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/subjective-cognitive-complaints-and-blood-biomarkers-of-37951931","doi":"10.1186/s13195-023-01341-3","journal":"Alzheimer's research & therapy","n_participants":6357,"pmid":"37951931","source_url":"https://pubmed.ncbi.nlm.nih.gov/37951931/","study_design":"case-control study","title":"Subjective cognitive complaints and blood biomarkers of neurodegenerative diseases: a longitudinal cohort study","title_match":false,"year":2023},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau181-levels-reflect-white-matter-35015198","doi":"10.1007/s11011-022-00908-7","journal":"Metabolic brain disease","n_participants":41,"pmid":"35015198","source_url":"https://pubmed.ncbi.nlm.nih.gov/35015198/","study_design":"prospective cohort","title":"Plasma phosphorylated-tau181 levels reflect white matter microstructural changes across Alzheimer's disease progression","title_match":false,"year":2022},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/platelet-amyloid-protein-precursor-app-ratio-and-phosphorylated-tau-31336382","doi":"10.1093/gerona/glz005","journal":"The journals of gerontology. Series A, Biological sciences and medical sciences","n_participants":null,"pmid":"31336382","source_url":"https://pubmed.ncbi.nlm.nih.gov/31336382/","study_design":"meta-analysis","title":"Platelet Amyloid-\u03b2 Protein Precursor (A\u03b2PP) Ratio and Phosphorylated Tau as Promising Indicators for Early Alzheimer's Disease","title_match":false,"year":2020},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/profiling-plasma-biomarkers-particularly-ptau217-and-ptau217-a42-and-40785395","doi":"10.1111/jnc.70182","journal":"Journal of neurochemistry","n_participants":80,"pmid":"40785395","source_url":"https://pubmed.ncbi.nlm.nih.gov/40785395/","study_design":null,"title":"Profiling Plasma Biomarkers, Particularly pTau217 and pTau217/A\u03b242, and Their Relation to Cognition in Memory Clinic Patients","title_match":true,"year":2025},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-of-alzheimer-s-disease-and-12-year-muscle-strength-40414227","doi":"10.1016/j.lanhl.2025.100715","journal":"The lancet. Healthy longevity","n_participants":3363,"pmid":"40414227","source_url":"https://pubmed.ncbi.nlm.nih.gov/40414227/","study_design":"cohort study","title":"Blood biomarkers of Alzheimer's disease and 12-year muscle strength trajectories in community-dwelling older adults: a cohort study","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/immunoassay-detection-of-multiphosphorylated-tau-proteoforms-as-39747866","doi":"10.1038/s41467-024-54878-8","journal":"Nature communications","n_participants":55,"pmid":"39747866","source_url":"https://pubmed.ncbi.nlm.nih.gov/39747866/","study_design":null,"title":"Immunoassay detection of multiphosphorylated tau proteoforms as cerebrospinal fluid and plasma Alzheimer's disease biomarkers","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau217-is-increased-in-niemann-pick-disease-39502943","doi":"10.1093/braincomms/fcae375","journal":"Brain communications","n_participants":60,"pmid":"39502943","source_url":"https://pubmed.ncbi.nlm.nih.gov/39502943/","study_design":"cross-sectional","title":"Plasma phosphorylated-tau217 is increased in Niemann-Pick disease type C","title_match":false,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/precivityad2tm-blood-test-analytical-validation-of-an-lc-ms-ms-assay-39202226","doi":"10.3390/diagnostics14161739","journal":"Diagnostics (Basel, Switzerland)","n_participants":null,"pmid":"39202226","source_url":"https://pubmed.ncbi.nlm.nih.gov/39202226/","study_design":null,"title":"PrecivityAD2\u2122 Blood Test: Analytical Validation of an LC-MS/MS Assay for Quantifying Plasma Phospho-tau217 and Non-Phospho-tau217 Peptide Concentrations That Are Used with Plasma Amyloid-\u03b242/40 in a Multianalyte Assay with Algorithmic Analysis for Detecting Brain Amyloid Pathology","title_match":true,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/nanoscale-flow-cytometry-based-quantification-of-blood-based-38958575","doi":"10.1002/alz.14087","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38958575","source_url":"https://pubmed.ncbi.nlm.nih.gov/38958575/","study_design":null,"title":"Nanoscale flow cytometry-based quantification of blood-based extracellular vesicle biomarkers distinguishes MCI and Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/influence-of-physiological-variables-and-comorbidities-on-plasma-a40-38338759","doi":"10.3390/ijms25031481","journal":"International journal of molecular sciences","n_participants":null,"pmid":"38338759","source_url":"https://pubmed.ncbi.nlm.nih.gov/38338759/","study_design":null,"title":"Influence of Physiological Variables and Comorbidities on Plasma A\u03b240, A\u03b242, and p-tau181 Levels in Cognitively Unimpaired Individuals","title_match":true,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/associations-of-the-a-t-n-profiles-in-pet-csf-and-plasma-biomarkers-37506291","doi":"10.1002/alz.13413","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":100,"pmid":"37506291","source_url":"https://pubmed.ncbi.nlm.nih.gov/37506291/","study_design":null,"title":"Associations of the A/T/N profiles in PET, CSF, and plasma biomarkers with Alzheimer's disease neuropathology at autopsy","title_match":true,"year":2023},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/green-tea-improves-cognitive-function-through-reducing-ad-pathology-35992609","doi":"10.3389/fnagi.2022.919766","journal":"Frontiers in aging neuroscience","n_participants":264,"pmid":"35992609","source_url":"https://pubmed.ncbi.nlm.nih.gov/35992609/","study_design":null,"title":"Green tea improves cognitive function through reducing AD-pathology and improving anti-oxidative stress capacity in Chinese middle-aged and elderly people","title_match":false,"year":2022},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/establishment-of-combined-diagnostic-models-of-alzheimer-s-disease-in-35710549","doi":"10.1038/s41398-022-02016-7","journal":"Translational psychiatry","n_participants":64,"pmid":"35710549","source_url":"https://pubmed.ncbi.nlm.nih.gov/35710549/","study_design":null,"title":"Establishment of combined diagnostic models of Alzheimer's disease in a Chinese cohort: the Chongqing Ageing & Dementia Study (CADS)","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-clinical-use-of-cerebrospinal-fluid-biomarkers-for-alzheimer-s-27911328","doi":"10.3233/jad-160975","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"27911328","source_url":"https://pubmed.ncbi.nlm.nih.gov/27911328/","study_design":null,"title":"The Clinical Use of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease Diagnosis: The Italian Selfie","title_match":false,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/role-of-cerebrospinal-fluid-biomarkers-to-predict-conversion-to-25274948","doi":"10.1515/cclm-2014-0414","journal":"Clinical chemistry and laboratory medicine","n_participants":null,"pmid":"25274948","source_url":"https://pubmed.ncbi.nlm.nih.gov/25274948/","study_design":null,"title":"Role of cerebrospinal fluid biomarkers to predict conversion to dementia in patients with mild cognitive impairment: a clinical cohort study","title_match":false,"year":2015},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/potential-utility-of-plasma-ptau217-for-assessing-amyloid-and-tau-40768095","doi":"10.1007/s00259-025-07457-y","journal":"European journal of nuclear medicine and molecular imaging","n_participants":2919,"pmid":"40768095","source_url":"https://pubmed.ncbi.nlm.nih.gov/40768095/","study_design":"longitudinal study","title":"Potential utility of plasma pTau217 for assessing amyloid and tau biomarker profiles","title_match":true,"year":2025},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/biofluid-based-staging-of-alzheimer-s-disease-40095069","doi":"10.1007/s00401-025-02863-w","journal":"Acta neuropathologica","n_participants":219,"pmid":"40095069","source_url":"https://pubmed.ncbi.nlm.nih.gov/40095069/","study_design":null,"title":"Biofluid-based staging of Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/blood-phosphorylated-tau181-reliably-differentiates-amyloid-positive-39822285","doi":"10.1002/dad2.70068","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"39822285","source_url":"https://pubmed.ncbi.nlm.nih.gov/39822285/","study_design":"systematic review","title":"Blood phosphorylated Tau181 reliably differentiates amyloid-positive from amyloid-negative subjects in the Alzheimer's disease continuum: A systematic review and meta-analysis","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/plasma-p-tau181-and-amyloid-markers-in-alzheimer-s-disease-a-39208716","doi":"10.1016/j.neurobiolaging.2024.08.007","journal":"Neurobiology of aging","n_participants":null,"pmid":"39208716","source_url":"https://pubmed.ncbi.nlm.nih.gov/39208716/","study_design":null,"title":"Plasma p-tau181 and amyloid markers in Alzheimer's disease: A comparison between Lumipulse and SIMOA","title_match":true,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/systematic-phenotyping-and-characterization-of-the-3xtg-ad-mouse-35140584","doi":"10.3389/fnins.2021.785276","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"35140584","source_url":"https://pubmed.ncbi.nlm.nih.gov/35140584/","study_design":null,"title":"Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-as-a-biomarker-of-alzheimer-s-35288777","doi":"10.1007/s00415-022-11055-5","journal":"Journal of neurology","n_participants":110,"pmid":"35288777","source_url":"https://pubmed.ncbi.nlm.nih.gov/35288777/","study_design":null,"title":"Plasma neurofilament light chain as a biomarker of Alzheimer's disease in Subjective Cognitive Decline and Mild Cognitive Impairment","title_match":false,"year":2022},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/using-the-alzheimer-s-disease-neuroimaging-initiative-to-improve-34581485","doi":"10.1002/alz.12422","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"34581485","source_url":"https://pubmed.ncbi.nlm.nih.gov/34581485/","study_design":null,"title":"Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/diagnostic-and-prognostic-value-of-serum-nfl-and-p-tau-sub-181-sub-in-32611664","doi":"10.1136/jnnp-2020-323487","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":417,"pmid":"32611664","source_url":"https://pubmed.ncbi.nlm.nih.gov/32611664/","study_design":"cross-sectional","title":"Diagnostic and prognostic value of serum NfL and p-Tau181 in frontotemporal lobar degeneration","title_match":true,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/an-update-on-blood-based-markers-of-alzheimer-s-disease-using-the-31833025","doi":"10.1007/s40120-019-00164-5","journal":"Neurology and therapy","n_participants":null,"pmid":"31833025","source_url":"https://pubmed.ncbi.nlm.nih.gov/31833025/","study_design":null,"title":"An Update on Blood-Based Markers of Alzheimer's Disease Using the SiMoA Platform","title_match":false,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/association-between-cerebrospinal-fluid-and-plasma-neurodegeneration-28692877","doi":"10.1016/j.neurobiolaging.2017.06.002","journal":"Neurobiology of aging","n_participants":null,"pmid":"28692877","source_url":"https://pubmed.ncbi.nlm.nih.gov/28692877/","study_design":null,"title":"Association between cerebrospinal fluid and plasma neurodegeneration biomarkers with brain atrophy in Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/medical-comorbidities-and-ethnicity-impact-plasma-alzheimer-s-disease-35235702","doi":"10.1002/alz.12647","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":445,"pmid":"35235702","source_url":"https://pubmed.ncbi.nlm.nih.gov/35235702/","study_design":null,"title":"Medical comorbidities and ethnicity impact plasma Alzheimer's disease biomarkers: Important considerations for clinical trials and practice","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/a-peripheral-signature-of-alzheimer-s-disease-featuring-microbiota-37254223","doi":"10.1186/s13195-023-01218-5","journal":"Alzheimer's research & therapy","n_participants":34,"pmid":"37254223","source_url":"https://pubmed.ncbi.nlm.nih.gov/37254223/","study_design":null,"title":"A peripheral signature of Alzheimer's disease featuring microbiota-gut-brain axis markers","title_match":false,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/profiling-of-serum-exosome-mirna-reveals-the-potential-of-a-mirna-33629272","doi":"10.1007/s12035-021-02323-y","journal":"Molecular neurobiology","n_participants":24,"pmid":"33629272","source_url":"https://pubmed.ncbi.nlm.nih.gov/33629272/","study_design":null,"title":"Profiling of Serum Exosome MiRNA Reveals the Potential of a MiRNA Panel as Diagnostic Biomarker for Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/serum-glial-fibrillary-acidic-protein-gfap-is-a-marker-of-disease-32804092","doi":"10.3233/jad-200608","journal":"Journal of Alzheimer's disease : JAD","n_participants":406,"pmid":"32804092","source_url":"https://pubmed.ncbi.nlm.nih.gov/32804092/","study_design":"cross-sectional","title":"Serum Glial Fibrillary Acidic Protein (GFAP) Is a Marker of Disease Severity in Frontotemporal Lobar Degeneration","title_match":false,"year":2020},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/serum-neurofilament-light-chain-is-a-discriminative-biomarker-between-31595378","doi":"10.1007/s00415-019-09567-8","journal":"Journal of neurology","n_participants":91,"pmid":"31595378","source_url":"https://pubmed.ncbi.nlm.nih.gov/31595378/","study_design":null,"title":"Serum neurofilament light chain is a discriminative biomarker between frontotemporal lobar degeneration and primary psychiatric disorders","title_match":false,"year":2020},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/neurofilament-light-chain-protein-in-neurodegenerative-dementia-a-31026486","doi":"10.1016/j.neubiorev.2019.04.014","journal":"Neuroscience and biobehavioral reviews","n_participants":null,"pmid":"31026486","source_url":"https://pubmed.ncbi.nlm.nih.gov/31026486/","study_design":"meta-analysis","title":"Neurofilament light chain protein in neurodegenerative dementia: A systematic review and network meta-analysis","title_match":false,"year":2019},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/transitioning-from-cerebrospinal-fluid-to-blood-tests-to-facilitate-34021943","doi":"10.1111/joim.13332","journal":"Journal of internal medicine","n_participants":null,"pmid":"34021943","source_url":"https://pubmed.ncbi.nlm.nih.gov/34021943/","study_design":null,"title":"Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's disease","title_match":true,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/comparison-of-csf-and-serum-neurofilament-light-and-heavy-chain-as-34417339","doi":"10.1136/jnnp-2021-327129","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":75,"pmid":"34417339","source_url":"https://pubmed.ncbi.nlm.nih.gov/34417339/","study_design":null,"title":"Comparison of CSF and serum neurofilament light and heavy chain as differential diagnostic biomarkers for ALS","title_match":false,"year":2022},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/longitudinal-measurement-of-serum-neurofilament-light-in-30786919","doi":"10.1186/s13195-019-0472-5","journal":"Alzheimer's research & therapy","n_participants":61,"pmid":"30786919","source_url":"https://pubmed.ncbi.nlm.nih.gov/30786919/","study_design":"longitudinal study","title":"Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/plasma-gfap-in-parkinson-s-disease-with-cognitive-impairment-and-its-36759508","doi":"10.1038/s41531-023-00447-7","journal":"NPJ Parkinson's disease","n_participants":31,"pmid":"36759508","source_url":"https://pubmed.ncbi.nlm.nih.gov/36759508/","study_design":null,"title":"Plasma GFAP in Parkinson's disease with cognitive impairment and its potential to predict conversion to dementia","title_match":true,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/detection-of-amyloid-positivity-in-alzheimer-s-disease-neuroimaging-33842885","doi":"10.1093/braincomms/fcab008","journal":"Brain communications","n_participants":null,"pmid":"33842885","source_url":"https://pubmed.ncbi.nlm.nih.gov/33842885/","study_design":null,"title":"Detection of \u03b2-amyloid positivity in Alzheimer's Disease Neuroimaging Initiative participants with demographics, cognition, MRI and plasma biomarkers","title_match":true,"year":2021},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-for-amyloid-tau-and-cytokines-in-down-syndrome-and-30902060","doi":"10.1186/s13195-019-0477-0","journal":"Alzheimer's research & therapy","n_participants":31,"pmid":"30902060","source_url":"https://pubmed.ncbi.nlm.nih.gov/30902060/","study_design":null,"title":"Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease","title_match":true,"year":2019},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/correlations-between-plasma-and-pet-beta-amyloid-levels-in-30497535","doi":"10.1186/s13195-018-0444-1","journal":"Alzheimer's research & therapy","n_participants":200,"pmid":"30497535","source_url":"https://pubmed.ncbi.nlm.nih.gov/30497535/","study_design":null,"title":"Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundaci\u00f3 ACE Healthy Brain Initiative (FACEHBI)","title_match":false,"year":2018},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-a-lt-sub-gt-42-lt-sub-gt-a-lt-sub-gt-40-lt-sub-gt-is-sensitive-39713875","doi":"10.1002/alz.14442","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39713875","source_url":"https://pubmed.ncbi.nlm.nih.gov/39713875/","study_design":"cross-sectional","title":"Plasma A\u03b242/A\u03b240 is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/a-two-step-immunoassay-for-the-simultaneous-assessment-of-a38-a40-and-30526652","doi":"10.1186/s13195-018-0448-x","journal":"Alzheimer's research & therapy","n_participants":23,"pmid":"30526652","source_url":"https://pubmed.ncbi.nlm.nih.gov/30526652/","study_design":null,"title":"A two-step immunoassay for the simultaneous assessment of A\u03b238, A\u03b240 and A\u03b242 in human blood plasma supports the A\u03b242/A\u03b240 ratio as a promising biomarker candidate of Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/concentrations-of-matrix-metalloproteinases-and-their-tissue-24448781","doi":"10.3233/jad-131634","journal":"Journal of Alzheimer's disease : JAD","n_participants":33,"pmid":"24448781","source_url":"https://pubmed.ncbi.nlm.nih.gov/24448781/","study_design":null,"title":"Concentrations of matrix metalloproteinases and their tissue inhibitors in the cerebrospinal fluid of patients with Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/evolution-of-abeta42-and-abeta40-levels-and-abeta42-abeta40-ratio-in-19262954","doi":"10.1007/s12603-009-0059-0","journal":"The journal of nutrition, health & aging","n_participants":null,"pmid":"19262954","source_url":"https://pubmed.ncbi.nlm.nih.gov/19262954/","study_design":"cross-sectional","title":"Evolution of Abeta42 and Abeta40 levels and Abeta42/Abeta40 ratio in plasma during progression of Alzheimer's disease: a multicenter assessment","title_match":false,"year":2009},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-peptides-in-canine-aging-and-cognitive-dysfunction-as-21377518","doi":"10.1016/j.exger.2011.02.013","journal":"Experimental gerontology","n_participants":null,"pmid":"21377518","source_url":"https://pubmed.ncbi.nlm.nih.gov/21377518/","study_design":null,"title":"Plasma \u03b2-amyloid peptides in canine aging and cognitive dysfunction as a model of Alzheimer's disease","title_match":false,"year":2011},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-glial-fibrillary-acidic-protein-is-associated-with-18f-smbt-1-36776057","doi":"10.3233/jad-220908","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"36776057","source_url":"https://pubmed.ncbi.nlm.nih.gov/36776057/","study_design":null,"title":"Plasma Glial Fibrillary Acidic Protein Is Associated with 18F-SMBT-1 PET: Two Putative Astrocyte Reactivity Biomarkers for Alzheimer's Disease","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/evaluation-of-visinin-like-protein-1-concentrations-in-the-25159667","doi":"10.3233/jad-141050","journal":"Journal of Alzheimer's disease : JAD","n_participants":33,"pmid":"25159667","source_url":"https://pubmed.ncbi.nlm.nih.gov/25159667/","study_design":null,"title":"Evaluation of visinin-like protein 1 concentrations in the cerebrospinal fluid of patients with mild cognitive impairment as a dynamic biomarker of Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/clinical-performance-of-an-antibody-free-assay-for-plasma-a42-a40-to-36604729","doi":"10.1186/s13195-022-01143-z","journal":"Alzheimer's research & therapy","n_participants":200,"pmid":"36604729","source_url":"https://pubmed.ncbi.nlm.nih.gov/36604729/","study_design":"cohort study","title":"Clinical performance of an antibody-free assay for plasma A\u03b242/A\u03b240 to detect early alterations of Alzheimer's disease in individuals with subjective cognitive decline","title_match":true,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/performance-of-the-plasma-a42-a40-ratio-measured-with-a-novel-hplc-ms-34686209","doi":"10.1186/s13195-021-00911-7","journal":"Alzheimer's research & therapy","n_participants":134,"pmid":"34686209","source_url":"https://pubmed.ncbi.nlm.nih.gov/34686209/","study_design":null,"title":"Performance of the plasma A\u03b242/A\u03b240 ratio, measured with a novel HPLC-MS/MS method, as a biomarker of amyloid PET status in a DPUK-KOREAN cohort","title_match":true,"year":2021},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/fluid-biomarker-based-molecular-phenotyping-of-alzheimer-s-disease-31699324","doi":"10.1016/bs.pmbts.2019.07.006","journal":"Progress in molecular biology and translational science","n_participants":null,"pmid":"31699324","source_url":"https://pubmed.ncbi.nlm.nih.gov/31699324/","study_design":null,"title":"Fluid biomarker-based molecular phenotyping of Alzheimer's disease patients in research and clinical settings","title_match":false,"year":2019},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/the-global-alzheimer-s-association-round-robin-study-on-plasma-34692980","doi":"10.1002/dad2.12242","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"34692980","source_url":"https://pubmed.ncbi.nlm.nih.gov/34692980/","study_design":null,"title":"The global Alzheimer's Association round robin study on plasma amyloid \u03b2 methods","title_match":true,"year":2021},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/the-contribution-of-vascular-risk-factors-in-neurodegenerative-32753051","doi":"10.1186/s13195-020-00658-7","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"32753051","source_url":"https://pubmed.ncbi.nlm.nih.gov/32753051/","study_design":"cross-sectional","title":"The contribution of vascular risk factors in neurodegenerative disorders: from mild cognitive impairment to Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/the-relationship-of-plasma-a-levels-to-dementia-in-aging-individuals-21440911","doi":"10.1016/j.jns.2011.03.005","journal":"Journal of the neurological sciences","n_participants":588,"pmid":"21440911","source_url":"https://pubmed.ncbi.nlm.nih.gov/21440911/","study_design":null,"title":"The relationship of plasma A\u03b2 levels to dementia in aging individuals with mild cognitive impairment","title_match":true,"year":2011},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-dynamics-in-late-life-major-depression-a-longitudinal-35902554","doi":"10.1038/s41398-022-02077-8","journal":"Translational psychiatry","n_participants":null,"pmid":"35902554","source_url":"https://pubmed.ncbi.nlm.nih.gov/35902554/","study_design":null,"title":"Plasma Amyloid-\u03b2 dynamics in late-life major depression: a longitudinal study","title_match":true,"year":2022},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/examining-the-association-between-blood-based-biomarkers-and-human-35266629","doi":"10.1002/alz.12639","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":90,"pmid":"35266629","source_url":"https://pubmed.ncbi.nlm.nih.gov/35266629/","study_design":null,"title":"Examining the association between blood-based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort","title_match":true,"year":2023},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-concentration-in-alzheimer-s-disease-performance-of-a-32176645","doi":"10.3233/jad-200046","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"32176645","source_url":"https://pubmed.ncbi.nlm.nih.gov/32176645/","study_design":"case-control study","title":"Plasma Amyloid Concentration in Alzheimer's Disease: Performance of a High-Throughput Amyloid Assay in Distinguishing Alzheimer's Disease Cases from Controls","title_match":true,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/differential-levels-of-p75ntr-ectodomain-in-csf-and-blood-in-patients-26440538","doi":"10.1038/tp.2015.146","journal":"Translational psychiatry","n_participants":null,"pmid":"26440538","source_url":"https://pubmed.ncbi.nlm.nih.gov/26440538/","study_design":null,"title":"Differential levels of p75NTR ectodomain in CSF and blood in patients with Alzheimer's disease: a novel diagnostic marker","title_match":false,"year":2015},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/fully-automated-and-highly-specific-plasma-amyloid-immunoassays-35739591","doi":"10.1186/s13195-022-01029-0","journal":"Alzheimer's research & therapy","n_participants":197,"pmid":"35739591","source_url":"https://pubmed.ncbi.nlm.nih.gov/35739591/","study_design":"clinical trial","title":"Fully automated and highly specific plasma \u03b2-amyloid immunoassays predict \u03b2-amyloid status defined by amyloid positron emission tomography with high accuracy","title_match":false,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/serum-amyloid-beta-protein-in-young-and-elderly-depression-a-pilot-20377819","doi":"10.1111/j.1479-8301.2009.00293.x","journal":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","n_participants":60,"pmid":"20377819","source_url":"https://pubmed.ncbi.nlm.nih.gov/20377819/","study_design":"cohort study","title":"Serum amyloid beta protein in young and elderly depression: a pilot study","title_match":false,"year":2009},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/independent-study-demonstrates-amyloid-probability-score-accurately-36975407","doi":"10.1002/acn3.51763","journal":"Annals of clinical and translational neurology","n_participants":13,"pmid":"36975407","source_url":"https://pubmed.ncbi.nlm.nih.gov/36975407/","study_design":null,"title":"Independent study demonstrates amyloid probability score accurately indicates amyloid pathology","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-beta-amyloid-level-and-depression-in-older-adults-22499763","doi":"10.1093/gerona/gls093","journal":"The journals of gerontology. Series A, Biological sciences and medical sciences","n_participants":null,"pmid":"22499763","source_url":"https://pubmed.ncbi.nlm.nih.gov/22499763/","study_design":"longitudinal study","title":"Plasma beta amyloid level and depression in older adults","title_match":false,"year":2013},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-of-alzheimer-s-disease-and-neurodegeneration-39350363","doi":"10.14283/jpad.2024.142","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"39350363","source_url":"https://pubmed.ncbi.nlm.nih.gov/39350363/","study_design":null,"title":"Plasma Biomarkers of Alzheimer's Disease and Neurodegeneration According to Sociodemographic Characteristics and Chronic Health Conditions","title_match":true,"year":2024},{"alzhub_score":81,"alzhub_url":"https://alzhub.org/study/plasma-a-as-a-biomarker-for-predicting-a-pet-status-in-alzheimer-s-35241627","doi":"10.1136/jnnp-2021-327864","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":3047,"pmid":"35241627","source_url":"https://pubmed.ncbi.nlm.nih.gov/35241627/","study_design":"meta-analysis","title":"Plasma A\u03b2 as a biomarker for predicting A\u03b2-PET status in Alzheimer's disease\uff1aa systematic review with meta-analysis","title_match":true,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/blood-derived-amyloid-biomarkers-for-alzheimer-s-disease-prevention-35098969","doi":"10.14283/jpad.2021.70","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"35098969","source_url":"https://pubmed.ncbi.nlm.nih.gov/35098969/","study_design":"cross-sectional","title":"Blood Derived Amyloid Biomarkers for Alzheimer's Disease Prevention","title_match":false,"year":2022},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/sorl1-gene-plasma-biomarkers-and-the-risk-of-alzheimer-s-disease-for-28034305","doi":"10.1186/s13195-016-0222-x","journal":"Alzheimer's research & therapy","n_participants":798,"pmid":"28034305","source_url":"https://pubmed.ncbi.nlm.nih.gov/28034305/","study_design":null,"title":"SORL1 gene, plasma biomarkers, and the risk of Alzheimer's disease for the Han Chinese population in Taiwan","title_match":true,"year":2016},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-total-tau-and-neurofilament-light-chain-across-the-37899059","doi":"10.3233/jad-230932","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"37899059","source_url":"https://pubmed.ncbi.nlm.nih.gov/37899059/","study_design":null,"title":"Plasma Amyloid-\u03b2, Total Tau, and Neurofilament Light Chain Across the Alzheimer's Disease Clinical Spectrum: A Population-Based Study","title_match":true,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-demographic-and-medical-correlates-of-plasma-a40-and-a42-22732677","doi":"10.1097/wad.0b013e318260a8cb","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"22732677","source_url":"https://pubmed.ncbi.nlm.nih.gov/22732677/","study_design":"cross-sectional","title":"The demographic and medical correlates of plasma a\u03b240 and a\u03b242","title_match":true,"year":2013},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/characterization-of-plasma-at-n-biomarkers-among-a-racial-and-39975470","doi":"10.1002/trc2.70045","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":764,"pmid":"39975470","source_url":"https://pubmed.ncbi.nlm.nih.gov/39975470/","study_design":null,"title":"Characterization of plasma AT(N) biomarkers among a racial and ethnically diverse community-based cohort: an HABS-HD study","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/fluid-biomarkers-in-dementia-diagnosis-35678404","doi":"10.1212/con.0000000000001083","journal":"Continuum (Minneapolis, Minn.)","n_participants":null,"pmid":"35678404","source_url":"https://pubmed.ncbi.nlm.nih.gov/35678404/","study_design":null,"title":"Fluid Biomarkers in Dementia Diagnosis","title_match":false,"year":2022},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/correlation-between-brain-structure-atrophy-and-plasma-amyloid-and-35547625","doi":"10.3389/fnagi.2022.816043","journal":"Frontiers in aging neuroscience","n_participants":33,"pmid":"35547625","source_url":"https://pubmed.ncbi.nlm.nih.gov/35547625/","study_design":null,"title":"Correlation Between Brain Structure Atrophy and Plasma Amyloid-\u03b2 and Phosphorylated Tau in Patients With Alzheimer's Disease and Amnestic Mild Cognitive Impairment Explored by Surface-Based Morphometry","title_match":true,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/clinical-utility-of-plasma-a42-40-ratio-by-lc-ms-ms-in-alzheimer-s-38595851","doi":"10.3389/fneur.2024.1364658","journal":"Frontiers in neurology","n_participants":null,"pmid":"38595851","source_url":"https://pubmed.ncbi.nlm.nih.gov/38595851/","study_design":null,"title":"Clinical utility of plasma A\u03b242/40 ratio by LC-MS/MS in Alzheimer's disease assessment","title_match":true,"year":2024},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/amyloid-levels-and-cognitive-trajectories-in-non-demented-ptau181-35973034","doi":"10.1093/brain/awac297","journal":"Brain : a journal of neurology","n_participants":154,"pmid":"35973034","source_url":"https://pubmed.ncbi.nlm.nih.gov/35973034/","study_design":"longitudinal study","title":"Amyloid-\u03b2 levels and cognitive trajectories in non-demented pTau181-positive subjects without amyloidopathy","title_match":true,"year":2022},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/plasma-a42-as-a-biomarker-of-prodromal-alzheimer-s-disease-30149449","doi":"10.3233/jad-180321","journal":"Journal of Alzheimer's disease : JAD","n_participants":76,"pmid":"30149449","source_url":"https://pubmed.ncbi.nlm.nih.gov/30149449/","study_design":"longitudinal study","title":"Plasma A\u03b242 as a Biomarker of Prodromal Alzheimer's Disease Progression in Patients with Amnestic Mild Cognitive Impairment: Evidence from the PharmaCog/E-ADNI Study","title_match":true,"year":2019},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/amyloid-related-cerebral-microbleed-and-plasma-a40-are-associated-33782518","doi":"10.1038/s41598-021-86617-0","journal":"Scientific reports","n_participants":135,"pmid":"33782518","source_url":"https://pubmed.ncbi.nlm.nih.gov/33782518/","study_design":null,"title":"Amyloid related cerebral microbleed and plasma A\u03b240 are associated with cognitive decline in Parkinson's disease","title_match":true,"year":2021},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/elevation-of-plasma-amyloid-level-is-more-significant-in-early-stage-29865072","doi":"10.3233/jad-180140","journal":"Journal of Alzheimer's disease : JAD","n_participants":1314,"pmid":"29865072","source_url":"https://pubmed.ncbi.nlm.nih.gov/29865072/","study_design":"cross-sectional","title":"Elevation of Plasma Amyloid-\u03b2 Level is More Significant in Early Stage of Cognitive Impairment: A Population-Based Cross-Sectional Study","title_match":true,"year":2018},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-and-cognitive-decline-in-patients-with-38489178","doi":"10.3233/jad-231096","journal":"Journal of Alzheimer's disease : JAD","n_participants":412,"pmid":"38489178","source_url":"https://pubmed.ncbi.nlm.nih.gov/38489178/","study_design":null,"title":"Alzheimer's Disease and Cognitive Decline in Patients with Cardiovascular Diseases Along the Heart-Brain Axis","title_match":false,"year":2024},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/association-of-plasma-a-sub-42-sub-a-sub-40-sub-ratio-and-late-onset-37541842","doi":"10.1212/wnl.0000000000207635","journal":"Neurology","n_participants":null,"pmid":"37541842","source_url":"https://pubmed.ncbi.nlm.nih.gov/37541842/","study_design":null,"title":"Association of Plasma A\u03b242/A\u03b240 Ratio and Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study","title_match":true,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/terminally-differentiated-effector-memory-t-cells-associate-with-38867294","doi":"10.1186/s12979-024-00443-2","journal":"Immunity & ageing : I & A","n_participants":84,"pmid":"38867294","source_url":"https://pubmed.ncbi.nlm.nih.gov/38867294/","study_design":null,"title":"Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort","title_match":false,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/definition-of-a-threshold-for-the-plasma-a42-a40-ratio-measured-by-38256246","doi":"10.3390/ijms25021173","journal":"International journal of molecular sciences","n_participants":88,"pmid":"38256246","source_url":"https://pubmed.ncbi.nlm.nih.gov/38256246/","study_design":null,"title":"Definition of a Threshold for the Plasma A\u03b242/A\u03b240 Ratio Measured by Single-Molecule Array to Predict the Amyloid Status of Individuals without Dementia","title_match":true,"year":2024},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/association-between-modifiable-risk-factors-and-levels-of-blood-based-38204926","doi":"10.14283/jarlife.2024.1","journal":"JAR life","n_participants":779,"pmid":"38204926","source_url":"https://pubmed.ncbi.nlm.nih.gov/38204926/","study_design":null,"title":"Association between Modifiable Risk Factors and Levels of Blood-Based Biomarkers of Alzheimer's and Related Dementias in the Look AHEAD Cohort","title_match":true,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/apoe-4-modulates-the-association-among-plasma-a-lt-sub-gt-42-lt-sub-35351867","doi":"10.1038/s41398-022-01899-w","journal":"Translational psychiatry","n_participants":null,"pmid":"35351867","source_url":"https://pubmed.ncbi.nlm.nih.gov/35351867/","study_design":"longitudinal study","title":"APOE-\u03b54 modulates the association among plasma A\u03b242/A\u03b240, vascular diseases, neurodegeneration and cognitive decline in non-demented elderly adults","title_match":true,"year":2022},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/performance-of-plasma-amyloid-total-tau-and-neurofilament-light-chain-34776933","doi":"10.3389/fnagi.2021.749649","journal":"Frontiers in aging neuroscience","n_participants":277,"pmid":"34776933","source_url":"https://pubmed.ncbi.nlm.nih.gov/34776933/","study_design":"cross-sectional","title":"Performance of Plasma Amyloid \u03b2, Total Tau, and Neurofilament Light Chain in the Identification of Probable Alzheimer's Disease in South China","title_match":true,"year":2021},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/levels-of-soluble-interleukin-6-receptor-and-asp358ala-are-associated-36810164","doi":"10.1212/nxi.0000000000200095","journal":"Neurology(R) neuroimmunology & neuroinflammation","n_participants":120,"pmid":"36810164","source_url":"https://pubmed.ncbi.nlm.nih.gov/36810164/","study_design":"cross-sectional","title":"Levels of Soluble Interleukin 6 Receptor and Asp358Ala Are Associated With Cognitive Performance and Alzheimer Disease Biomarkers","title_match":false,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/erlangen-score-as-a-tool-to-predict-progression-from-mild-cognitive-30611311","doi":"10.1186/s13195-018-0456-x","journal":"Alzheimer's research & therapy","n_participants":47,"pmid":"30611311","source_url":"https://pubmed.ncbi.nlm.nih.gov/30611311/","study_design":null,"title":"Erlangen Score as a tool to predict progression from mild cognitive impairment to dementia in Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":78,"alzhub_url":"https://alzhub.org/study/whole-exome-sequence-based-association-analyses-of-plasma-amyloid-in-28704393","doi":"10.1371/journal.pone.0180046","journal":"PloS one","n_participants":725,"pmid":"28704393","source_url":"https://pubmed.ncbi.nlm.nih.gov/28704393/","study_design":"meta-analysis","title":"Whole exome sequence-based association analyses of plasma amyloid-\u03b2 in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study","title_match":true,"year":2017},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-peptides-in-type-2-diabetes-a-matched-case-control-28106562","doi":"10.3233/jad-161050","journal":"Journal of Alzheimer's disease : JAD","n_participants":194,"pmid":"28106562","source_url":"https://pubmed.ncbi.nlm.nih.gov/28106562/","study_design":null,"title":"Plasma Amyloid-\u03b2 Peptides in Type 2 Diabetes: A Matched Case-Control Study","title_match":true,"year":2017},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/plasma-ptau181-reveals-a-pathological-signature-that-predicts-38888142","doi":"10.1002/ana.27003","journal":"Annals of neurology","n_participants":565,"pmid":"38888142","source_url":"https://pubmed.ncbi.nlm.nih.gov/38888142/","study_design":"longitudinal study","title":"Plasma pTau181 Reveals a Pathological Signature that Predicts Cognitive Outcomes in Lewy Body Disease","title_match":true,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/serum-ngal-is-associated-with-distinct-plasma-amyloid-peptides-25613101","doi":"10.3233/jad-142514","journal":"Journal of Alzheimer's disease : JAD","n_participants":67,"pmid":"25613101","source_url":"https://pubmed.ncbi.nlm.nih.gov/25613101/","study_design":null,"title":"Serum NGAL is Associated with Distinct Plasma Amyloid-\u03b2 Peptides According to the Clinical Diagnosis of Dementia in Down Syndrome","title_match":true,"year":2015},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/associations-of-midlife-lifestyle-and-health-factors-with-long-term-37393497","doi":"10.3233/jad-221287","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"37393497","source_url":"https://pubmed.ncbi.nlm.nih.gov/37393497/","study_design":"longitudinal study","title":"Associations of Midlife Lifestyle and Health Factors with Long-Term Changes in Blood-Based Biomarkers of Alzheimer's Disease and Neurodegeneration","title_match":true,"year":2023},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/the-corcobia-study-cut-off-points-of-alzheimer-s-disease-csf-35961506","doi":"10.1016/j.nrleng.2022.05.002","journal":"Neurologia","n_participants":42,"pmid":"35961506","source_url":"https://pubmed.ncbi.nlm.nih.gov/35961506/","study_design":null,"title":"The CORCOBIA study: Cut-off points of Alzheimer's disease CSF biomarkers in a clinical cohort","title_match":false,"year":2024},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/predicting-longitudinal-cognitive-decline-and-alzheimer-s-conversion-38994939","doi":"10.3390/cells13131085","journal":"Cells","n_participants":50,"pmid":"38994939","source_url":"https://pubmed.ncbi.nlm.nih.gov/38994939/","study_design":"cohort study","title":"Predicting Longitudinal Cognitive Decline and Alzheimer's Conversion in Mild Cognitive Impairment Patients Based on Plasma Biomarkers","title_match":true,"year":2024},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/comparison-of-plasma-soluble-and-extracellular-vesicles-associated-38943196","doi":"10.1186/s13195-024-01508-6","journal":"Alzheimer's research & therapy","n_participants":168,"pmid":"38943196","source_url":"https://pubmed.ncbi.nlm.nih.gov/38943196/","study_design":null,"title":"Comparison of plasma soluble and extracellular vesicles-associated biomarkers in Alzheimer's disease patients and cognitively normal individuals","title_match":false,"year":2024},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/multi-night-acoustic-stimulation-is-associated-with-better-sleep-38744792","doi":"10.1007/s11357-024-01195-z","journal":"GeroScience","n_participants":null,"pmid":"38744792","source_url":"https://pubmed.ncbi.nlm.nih.gov/38744792/","study_design":null,"title":"Multi-night acoustic stimulation is associated with better sleep, amyloid dynamics, and memory in older adults with cognitive impairment","title_match":false,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/the-associations-between-synaptic-density-and-a-t-n-biomarkers-in-38295871","doi":"10.1177/0271678x241230733","journal":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","n_participants":97,"pmid":"38295871","source_url":"https://pubmed.ncbi.nlm.nih.gov/38295871/","study_design":null,"title":"The associations between synaptic density and \"A/T/N\" biomarkers in Alzheimer's disease: An 18F-SynVesT-1 PET/MR study","title_match":false,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/csf-and-plasma-a42-40-across-alzheimer-s-disease-continuum-comparison-37656487","doi":"10.1515/cclm-2023-0659","journal":"Clinical chemistry and laboratory medicine","n_participants":19,"pmid":"37656487","source_url":"https://pubmed.ncbi.nlm.nih.gov/37656487/","study_design":null,"title":"CSF and plasma A\u03b242/40 across Alzheimer's disease continuum: comparison of two ultrasensitive Simoa\u00ae assays targeting distinct amyloid regions","title_match":true,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/the-heritability-of-blood-based-biomarkers-related-to-risk-of-37622539","doi":"10.1002/alz.13407","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37622539","source_url":"https://pubmed.ncbi.nlm.nih.gov/37622539/","study_design":null,"title":"The heritability of blood-based biomarkers related to risk of Alzheimer's disease in a population-based sample of early old-age men","title_match":true,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/plasma-core-alzheimer-s-disease-biomarkers-predict-amyloid-deposition-36547971","doi":"10.1021/acschemneuro.2c00636","journal":"ACS chemical neuroscience","n_participants":null,"pmid":"36547971","source_url":"https://pubmed.ncbi.nlm.nih.gov/36547971/","study_design":null,"title":"Plasma Core Alzheimer's Disease Biomarkers Predict Amyloid Deposition Burden by Positron Emission Tomography in Chinese Individuals with Cognitive Decline","title_match":false,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/association-between-life-s-simple-7-and-cerebrospinal-fluid-35619174","doi":"10.1186/s13195-022-01019-2","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"35619174","source_url":"https://pubmed.ncbi.nlm.nih.gov/35619174/","study_design":null,"title":"Association between Life's Simple 7 and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: the CABLE study","title_match":false,"year":2022},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/associations-of-risk-genes-with-onset-age-and-plasma-biomarkers-of-35001095","doi":"10.1038/s41386-021-01258-1","journal":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","n_participants":3604,"pmid":"35001095","source_url":"https://pubmed.ncbi.nlm.nih.gov/35001095/","study_design":null,"title":"Associations of risk genes with onset age and plasma biomarkers of Alzheimer's disease: a large case-control study in mainland China","title_match":true,"year":2022},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/lecanemab-associated-amyloid-protofibril-in-cerebrospinal-fluid-39761671","doi":"10.1002/ana.27175","journal":"Annals of neurology","n_participants":163,"pmid":"39761671","source_url":"https://pubmed.ncbi.nlm.nih.gov/39761671/","study_design":null,"title":"Lecanemab-Associated Amyloid-\u03b2 Protofibril in Cerebrospinal Fluid Correlates with Biomarkers of Neurodegeneration in Alzheimer's Disease","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/pathological-angiogenesis-was-associated-with-cerebrovascular-lesion-39777972","doi":"10.1002/alz.14521","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39777972","source_url":"https://pubmed.ncbi.nlm.nih.gov/39777972/","study_design":null,"title":"Pathological angiogenesis was associated with cerebrovascular lesion and neurodegeneration in Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/short-term-variability-of-alzheimer-s-disease-plasma-biomarkers-in-a-39838483","doi":"10.1186/s13195-024-01658-7","journal":"Alzheimer's research & therapy","n_participants":27,"pmid":"39838483","source_url":"https://pubmed.ncbi.nlm.nih.gov/39838483/","study_design":"longitudinal study","title":"Short-term variability of Alzheimer's disease plasma biomarkers in a mixed memory clinic cohort","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/association-between-glymphatic-system-function-and-cognitive-39827682","doi":"10.1016/j.yebeh.2024.110258","journal":"Epilepsy & behavior : E&B","n_participants":null,"pmid":"39827682","source_url":"https://pubmed.ncbi.nlm.nih.gov/39827682/","study_design":"post-hoc analysis","title":"Association between glymphatic system function and cognitive impairment in elderly patients with late-onset epilepsy","title_match":false,"year":2025},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/performance-of-plasma-biomarkers-combined-with-structural-mri-to-39350364","doi":"10.14283/jpad.2024.110","journal":"The journal of prevention of Alzheimer's disease","n_participants":428,"pmid":"39350364","source_url":"https://pubmed.ncbi.nlm.nih.gov/39350364/","study_design":"cross-sectional","title":"Performance of Plasma Biomarkers Combined with Structural MRI to Identify Candidate Participants for Alzheimer's Disease-Modifying Therapy","title_match":true,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/diagnostic-value-of-isolated-plasma-biomarkers-and-its-combination-in-38588788","doi":"10.1016/j.cca.2024.118784","journal":"Clinica chimica acta; international journal of clinical chemistry","n_participants":92,"pmid":"38588788","source_url":"https://pubmed.ncbi.nlm.nih.gov/38588788/","study_design":null,"title":"Diagnostic value of isolated plasma biomarkers and its combination in neurodegenerative dementias: A multicenter cohort study","title_match":true,"year":2024},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/the-hippocampal-subfield-volume-reduction-and-plasma-biomarker-38489180","doi":"10.3233/jad-231114","journal":"Journal of Alzheimer's disease : JAD","n_participants":40,"pmid":"38489180","source_url":"https://pubmed.ncbi.nlm.nih.gov/38489180/","study_design":"cross-sectional","title":"The Hippocampal Subfield Volume Reduction and Plasma Biomarker Changes in Mild Cognitive Impairment and Alzheimer's Disease","title_match":true,"year":2024},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/prospective-analysis-of-plasma-amyloid-beta-and-postoperative-36842841","doi":"10.1016/j.bja.2023.01.020","journal":"British journal of anaesthesia","n_participants":100,"pmid":"36842841","source_url":"https://pubmed.ncbi.nlm.nih.gov/36842841/","study_design":"cohort study","title":"Prospective analysis of plasma amyloid beta and postoperative delirium in the Interventions for Postoperative Delirium: Biomarker-3 study","title_match":true,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/the-association-of-subjective-sleep-characteristics-and-plasma-36806992","doi":"10.1007/s00415-023-11626-0","journal":"Journal of neurology","n_participants":335,"pmid":"36806992","source_url":"https://pubmed.ncbi.nlm.nih.gov/36806992/","study_design":null,"title":"The association of subjective sleep characteristics and plasma biomarkers of Alzheimer's disease pathology in older cognitively unimpaired adults with higher amyloid-\u03b2 burden","title_match":true,"year":2023},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/potential-association-of-bone-mineral-density-loss-with-cognitive-35773707","doi":"10.1186/s12891-022-05580-7","journal":"BMC musculoskeletal disorders","n_participants":null,"pmid":"35773707","source_url":"https://pubmed.ncbi.nlm.nih.gov/35773707/","study_design":"cross-sectional","title":"Potential association of bone mineral density loss with cognitive impairment and central and peripheral amyloid-\u03b2 changes: a cross-sectional study","title_match":false,"year":2022},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/novel-ultrasensitive-detection-technologies-for-the-identification-of-35213367","doi":"10.3233/jad-215093","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"35213367","source_url":"https://pubmed.ncbi.nlm.nih.gov/35213367/","study_design":"systematic review","title":"Novel Ultrasensitive Detection Technologies for the Identification of Early and Minimally Invasive Alzheimer's Disease Blood Biomarkers","title_match":false,"year":2022},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/elevated-plasma-a42-in-cognitively-impaired-individuals-taking-ace-28449585","doi":"10.1177/1533317517707288","journal":"American journal of Alzheimer's disease and other dementias","n_participants":null,"pmid":"28449585","source_url":"https://pubmed.ncbi.nlm.nih.gov/28449585/","study_design":null,"title":"Elevated Plasma A\u03b242 in Cognitively Impaired Individuals Taking ACE Inhibitor Antihypertensives","title_match":true,"year":2017},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/combination-of-plasma-biomarkers-and-clinical-data-for-the-detection-22503901","doi":"10.1016/j.neulet.2012.03.094","journal":"Neuroscience letters","n_participants":112,"pmid":"22503901","source_url":"https://pubmed.ncbi.nlm.nih.gov/22503901/","study_design":null,"title":"Combination of plasma biomarkers and clinical data for the detection of sporadic Alzheimer's disease","title_match":true,"year":2012},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/lysophosphatidylcholines-are-associated-with-amyloidosis-in-early-41407938","doi":"10.1038/s43587-025-01025-7","journal":"Nature aging","n_participants":1068,"pmid":"41407938","source_url":"https://pubmed.ncbi.nlm.nih.gov/41407938/","study_design":null,"title":"Lysophosphatidylcholines are associated with amyloidosis in early stages of Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/accuracy-of-plasma-biomarkers-to-detect-alzheimer-s-disease-40108829","doi":"10.1002/alz.14570","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":304,"pmid":"40108829","source_url":"https://pubmed.ncbi.nlm.nih.gov/40108829/","study_design":"cohort study","title":"Accuracy of plasma biomarkers to detect Alzheimer's disease proteinopathy prior to dementia","title_match":true,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/evaluation-of-core-biomarkers-of-alzheimer-s-disease-in-saliva-and-38992063","doi":"10.1038/s41598-024-66923-z","journal":"Scientific reports","n_participants":null,"pmid":"38992063","source_url":"https://pubmed.ncbi.nlm.nih.gov/38992063/","study_design":null,"title":"Evaluation of core Biomarkers of Alzheimer's disease in saliva and plasma measured by chemiluminescent enzyme immunoassays on a fully automated platform","title_match":false,"year":2024},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/assessment-of-the-correlation-and-diagnostic-accuracy-between-38731812","doi":"10.3390/ijms25094594","journal":"International journal of molecular sciences","n_participants":81,"pmid":"38731812","source_url":"https://pubmed.ncbi.nlm.nih.gov/38731812/","study_design":null,"title":"Assessment of the Correlation and Diagnostic Accuracy between Cerebrospinal Fluid and Plasma Alzheimer's Disease Biomarkers: A Comparison of the Lumipulse and Simoa Platforms","title_match":false,"year":2024},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/exploring-the-potential-of-fully-automated-lumipulse-g-plasma-assays-38454502","doi":"10.1186/s13195-024-01397-9","journal":"Alzheimer's research & therapy","n_participants":138,"pmid":"38454502","source_url":"https://pubmed.ncbi.nlm.nih.gov/38454502/","study_design":null,"title":"Exploring the potential of fully automated LUMIPULSE G plasma assays for detecting Alzheimer's disease pathology","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/correlation-of-serum-complement-factor-5a-level-with-inflammatory-37679689","doi":"10.1186/s12883-023-03256-w","journal":"BMC neurology","n_participants":null,"pmid":"37679689","source_url":"https://pubmed.ncbi.nlm.nih.gov/37679689/","study_design":null,"title":"Correlation of serum complement factor 5a level with inflammatory response and cognitive function in patients with Alzheimer's disease of different severity","title_match":false,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-neurofilament-light-chain-and-total-tau-as-37652185","doi":"10.1016/j.nbd.2023.106267","journal":"Neurobiology of disease","n_participants":72,"pmid":"37652185","source_url":"https://pubmed.ncbi.nlm.nih.gov/37652185/","study_design":null,"title":"Cerebrospinal fluid neurofilament light chain and total-tau as biomarkers of neurodegeneration in Alzheimer's disease and frontotemporal dementia","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/influence-of-kidney-function-and-csf-serum-albumin-ratio-on-plasma-37284933","doi":"10.1007/s10072-023-06882-x","journal":"Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology","n_participants":30,"pmid":"37284933","source_url":"https://pubmed.ncbi.nlm.nih.gov/37284933/","study_design":null,"title":"Influence of kidney function and CSF/serum albumin ratio on plasma A\u03b242 and A\u03b240 levels measured on a fully automated platform in patients with Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/evaluation-of-bcg-vaccination-and-plasma-amyloid-a-prospective-pilot-35208878","doi":"10.3390/microorganisms10020424","journal":"Microorganisms","n_participants":null,"pmid":"35208878","source_url":"https://pubmed.ncbi.nlm.nih.gov/35208878/","study_design":"open-label trial","title":"Evaluation of BCG Vaccination and Plasma Amyloid: A Prospective, Pilot Study with Implications for Alzheimer's Disease","title_match":true,"year":2022},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/biomarkers-of-inflammation-and-amyloid-beta-phagocytosis-in-patients-19699791","doi":"10.1016/j.exger.2009.08.003","journal":"Experimental gerontology","n_participants":null,"pmid":"19699791","source_url":"https://pubmed.ncbi.nlm.nih.gov/19699791/","study_design":null,"title":"Biomarkers of inflammation and amyloid-beta phagocytosis in patients at risk of Alzheimer disease","title_match":false,"year":2010},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/anxiety-correlates-with-cortical-surface-area-in-subjective-cognitive-31159873","doi":"10.1186/s13195-019-0505-0","journal":"Alzheimer's research & therapy","n_participants":65,"pmid":"31159873","source_url":"https://pubmed.ncbi.nlm.nih.gov/31159873/","study_design":null,"title":"Anxiety correlates with cortical surface area in subjective cognitive decline: APOE \u03b54 carriers versus APOE \u03b54 non-carriers","title_match":false,"year":2019},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/serum-nfl-discriminates-parkinson-disease-from-essential-tremor-and-35086487","doi":"10.1186/s12883-022-02558-9","journal":"BMC neurology","n_participants":null,"pmid":"35086487","source_url":"https://pubmed.ncbi.nlm.nih.gov/35086487/","study_design":"cross-sectional","title":"Serum NFL discriminates Parkinson disease from essential tremor and reflect motor and cognition severity","title_match":true,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/comparative-analyses-of-plasma-amyloid-levels-in-heterogeneous-and-31001580","doi":"10.1126/sciadv.aav1388","journal":"Science advances","n_participants":null,"pmid":"31001580","source_url":"https://pubmed.ncbi.nlm.nih.gov/31001580/","study_design":null,"title":"Comparative analyses of plasma amyloid-\u03b2 levels in heterogeneous and monomerized states by interdigitated microelectrode sensor system","title_match":true,"year":2019},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/vitamin-d-deficiency-was-common-among-nursing-home-residents-and-29017462","doi":"10.1186/s12877-017-0622-1","journal":"BMC geriatrics","n_participants":null,"pmid":"29017462","source_url":"https://pubmed.ncbi.nlm.nih.gov/29017462/","study_design":"cross-sectional","title":"Vitamin D deficiency was common among nursing home residents and associated with dementia: a cross sectional study of 545 Swedish nursing home residents","title_match":false,"year":2017},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-for-alzheimer-s-disease-much-promise-cautious-27738910","doi":"10.1007/s40291-016-0241-0","journal":"Molecular diagnosis & therapy","n_participants":null,"pmid":"27738910","source_url":"https://pubmed.ncbi.nlm.nih.gov/27738910/","study_design":"longitudinal study","title":"Blood Biomarkers for Alzheimer's Disease: Much Promise, Cautious Progress","title_match":false,"year":2017},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/longitudinal-progression-of-blood-biomarkers-reveals-a-key-role-of-40494355","doi":"10.1016/j.medj.2025.100724","journal":"Med (New York, N.Y.)","n_participants":158,"pmid":"40494355","source_url":"https://pubmed.ncbi.nlm.nih.gov/40494355/","study_design":"case-control study","title":"Longitudinal progression of blood biomarkers reveals a key role of reactive astrocytosis in preclinical Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-mia-crp-and-albumin-predict-cognitive-decline-in-parkinson-s-35593028","doi":"10.1002/ana.26410","journal":"Annals of neurology","n_participants":118,"pmid":"35593028","source_url":"https://pubmed.ncbi.nlm.nih.gov/35593028/","study_design":null,"title":"Plasma MIA, CRP, and Albumin Predict Cognitive Decline in Parkinson's Disease","title_match":false,"year":2022},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/a-candidate-plasma-protein-classifier-to-identify-alzheimer-s-disease-25114072","doi":"10.3233/jad-141149","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"25114072","source_url":"https://pubmed.ncbi.nlm.nih.gov/25114072/","study_design":null,"title":"A candidate plasma protein classifier to identify Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/a-blood-based-multi-pathway-biomarker-assay-for-early-detection-and-38183344","doi":"10.1002/alz.13676","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38183344","source_url":"https://pubmed.ncbi.nlm.nih.gov/38183344/","study_design":null,"title":"A blood-based multi-pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups","title_match":false,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/predicting-alzheimer-disease-from-a-blood-based-biomarker-profile-a-27534714","doi":"10.1212/wnl.0000000000003094","journal":"Neurology","n_participants":74,"pmid":"27534714","source_url":"https://pubmed.ncbi.nlm.nih.gov/27534714/","study_design":null,"title":"Predicting Alzheimer disease from a blood-based biomarker profile: A 54-month follow-up","title_match":true,"year":2016},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-apolipoprotein-j-as-a-potential-biomarker-for-alzheimer-s-27239546","doi":"10.1016/j.dadm.2015.12.001","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":833,"pmid":"27239546","source_url":"https://pubmed.ncbi.nlm.nih.gov/27239546/","study_design":null,"title":"Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging","title_match":false,"year":2016},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/association-of-midlife-plasma-amyloid-levels-with-cognitive-34349010","doi":"10.1212/wnl.0000000000012482","journal":"Neurology","n_participants":2284,"pmid":"34349010","source_url":"https://pubmed.ncbi.nlm.nih.gov/34349010/","study_design":"cohort study","title":"Association of Midlife Plasma Amyloid-\u03b2 Levels With Cognitive Impairment in Late Life: The ARIC Neurocognitive Study","title_match":true,"year":2021},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/altered-levels-of-blood-proteins-in-alzheimer-s-disease-longitudinal-28508031","doi":"10.1016/j.dadm.2017.04.003","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":14,"pmid":"28508031","source_url":"https://pubmed.ncbi.nlm.nih.gov/28508031/","study_design":"longitudinal study","title":"Altered levels of blood proteins in Alzheimer's disease longitudinal study: Results from Australian Imaging Biomarkers Lifestyle Study of Ageing cohort","title_match":false,"year":2017},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/an-enzyme-generated-fragment-of-tau-measured-in-serum-shows-an-23717682","doi":"10.1371/journal.pone.0064990","journal":"PloS one","n_participants":null,"pmid":"23717682","source_url":"https://pubmed.ncbi.nlm.nih.gov/23717682/","study_design":null,"title":"An enzyme-generated fragment of tau measured in serum shows an inverse correlation to cognitive function","title_match":false,"year":2013},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/potential-implications-of-mirnas-in-the-pathogenesis-diagnosis-and-38003448","doi":"10.3390/ijms242216259","journal":"International journal of molecular sciences","n_participants":null,"pmid":"38003448","source_url":"https://pubmed.ncbi.nlm.nih.gov/38003448/","study_design":null,"title":"Potential Implications of miRNAs in the Pathogenesis, Diagnosis, and Therapeutics of Alzheimer's Disease","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apoe-4-gene-dose-effect-on-imaging-and-blood-biomarkers-of-37016464","doi":"10.1186/s13195-023-01209-6","journal":"Alzheimer's research & therapy","n_participants":19,"pmid":"37016464","source_url":"https://pubmed.ncbi.nlm.nih.gov/37016464/","study_design":null,"title":"APOE \u03b54 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly","title_match":false,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/prognostic-plasma-protein-panel-for-a-deposition-in-the-brain-in-31605717","doi":"10.1016/j.pneurobio.2019.101690","journal":"Progress in neurobiology","n_participants":107,"pmid":"31605717","source_url":"https://pubmed.ncbi.nlm.nih.gov/31605717/","study_design":null,"title":"Prognostic plasma protein panel for A\u03b2 deposition in the brain in Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-blood-based-biomarker-panel-indicates-il-10-and-il-12-23p40-are-29070909","doi":"10.1038/s41598-017-14020-9","journal":"Scientific reports","n_participants":null,"pmid":"29070909","source_url":"https://pubmed.ncbi.nlm.nih.gov/29070909/","study_design":null,"title":"A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of \u03b2-amyloid load in an AD cohort","title_match":true,"year":2017},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/blood-metabolite-markers-of-neocortical-amyloid-burden-discovery-and-26812040","doi":"10.1038/tp.2015.205","journal":"Translational psychiatry","n_participants":91,"pmid":"26812040","source_url":"https://pubmed.ncbi.nlm.nih.gov/26812040/","study_design":null,"title":"Blood metabolite markers of neocortical amyloid-\u03b2 burden: discovery and enrichment using candidate proteins","title_match":false,"year":2016},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/practical-detection-of-a-definitive-biomarker-panel-for-alzheimer-s-24959311","doi":null,"journal":"International journal of molecular epidemiology and genetics","n_participants":null,"pmid":"24959311","source_url":"https://pubmed.ncbi.nlm.nih.gov/24959311/","study_design":null,"title":"Practical detection of a definitive biomarker panel for Alzheimer's disease; comparisons between matched plasma and cerebrospinal fluid","title_match":false,"year":2014},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/preferential-interactions-between-apoe-containing-lipoproteins-and-a-22138302","doi":"10.1016/j.bbalip.2011.11.005","journal":"Biochimica et biophysica acta","n_participants":null,"pmid":"22138302","source_url":"https://pubmed.ncbi.nlm.nih.gov/22138302/","study_design":null,"title":"Preferential interactions between ApoE-containing lipoproteins and A\u03b2 revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shift","title_match":false,"year":2012},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/comparative-methods-for-quantifying-plasma-biomarkers-in-alzheimer-s-37908054","doi":"10.1002/alz.13510","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37908054","source_url":"https://pubmed.ncbi.nlm.nih.gov/37908054/","study_design":null,"title":"Comparative methods for quantifying plasma biomarkers in Alzheimer's disease: Implications for the next frontier in cerebral amyloid angiopathy diagnostics","title_match":true,"year":2024},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/longitudinal-data-in-peripheral-blood-confirm-that-pm20d1-is-a-33298155","doi":"10.1186/s13148-020-00984-5","journal":"Clinical epigenetics","n_participants":649,"pmid":"33298155","source_url":"https://pubmed.ncbi.nlm.nih.gov/33298155/","study_design":"longitudinal study","title":"Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer's disease and implicate its dynamic role in disease progression","title_match":false,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/diagnostic-utility-of-vegf-and-soluble-cd40l-levels-in-serum-of-26706786","doi":"10.1016/j.cca.2015.12.018","journal":"Clinica chimica acta; international journal of clinical chemistry","n_participants":90,"pmid":"26706786","source_url":"https://pubmed.ncbi.nlm.nih.gov/26706786/","study_design":null,"title":"Diagnostic utility of VEGF and soluble CD40L levels in serum of Alzheimer's patients","title_match":false,"year":2016},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/utilization-of-fluid-based-biomarkers-as-endpoints-in-disease-38678292","doi":"10.1186/s13195-024-01456-1","journal":"Alzheimer's research & therapy","n_participants":121,"pmid":"38678292","source_url":"https://pubmed.ncbi.nlm.nih.gov/38678292/","study_design":null,"title":"Utilization of fluid-based biomarkers as endpoints in disease-modifying clinical trials for Alzheimer's disease: a systematic review","title_match":false,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/use-of-a-blood-biomarker-test-improves-economic-utility-in-the-38546435","doi":"10.1089/pop.2023.0309","journal":"Population health management","n_participants":null,"pmid":"38546435","source_url":"https://pubmed.ncbi.nlm.nih.gov/38546435/","study_design":null,"title":"Use of a Blood Biomarker Test Improves Economic Utility in the Evaluation of Older Patients Presenting with Cognitive Impairment","title_match":false,"year":2024},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-beta-oligomer-is-related-to-subjective-cognitive-36324157","doi":"10.1186/s13195-022-01104-6","journal":"Alzheimer's research & therapy","n_participants":126,"pmid":"36324157","source_url":"https://pubmed.ncbi.nlm.nih.gov/36324157/","study_design":"cross-sectional","title":"Plasma amyloid-beta oligomer is related to subjective cognitive decline and brain amyloid status","title_match":true,"year":2022},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/a-conformation-variant-of-p53-combined-with-machine-learning-33375220","doi":"10.3390/jpm11010014","journal":"Journal of personalized medicine","n_participants":null,"pmid":"33375220","source_url":"https://pubmed.ncbi.nlm.nih.gov/33375220/","study_design":"longitudinal study","title":"A Conformation Variant of p53 Combined with Machine Learning Identifies Alzheimer Disease in Preclinical and Prodromal Stages","title_match":false,"year":2020},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/nanoparticle-based-immunomagnetic-assay-of-plasma-biomarkers-for-32222476","doi":"10.1016/j.nano.2020.102182","journal":"Nanomedicine : nanotechnology, biology, and medicine","n_participants":160,"pmid":"32222476","source_url":"https://pubmed.ncbi.nlm.nih.gov/32222476/","study_design":null,"title":"Nanoparticle-based immunomagnetic assay of plasma biomarkers for differentiating dementia and prodromal states of Alzheimer's disease - A cross-validation study","title_match":true,"year":2020},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/blood-based-oligomeric-and-other-protein-variant-biomarkers-to-28372328","doi":"10.3233/jad-161116","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"28372328","source_url":"https://pubmed.ncbi.nlm.nih.gov/28372328/","study_design":"longitudinal study","title":"Blood-Based Oligomeric and Other Protein Variant Biomarkers to Facilitate Pre-Symptomatic Diagnosis and Staging of Alzheimer's Disease","title_match":false,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/tdp-43-protein-variants-as-biomarkers-in-amyotrophic-lateral-sclerosis-28122516","doi":"10.1186/s12868-017-0334-7","journal":"BMC neuroscience","n_participants":null,"pmid":"28122516","source_url":"https://pubmed.ncbi.nlm.nih.gov/28122516/","study_design":null,"title":"TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis","title_match":false,"year":2017},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/mri-and-fluid-biomarkers-reveal-determinants-of-myelin-and-axonal-36762407","doi":"10.1002/acn3.51730","journal":"Annals of clinical and translational neurology","n_participants":119,"pmid":"36762407","source_url":"https://pubmed.ncbi.nlm.nih.gov/36762407/","study_design":null,"title":"MRI and fluid biomarkers reveal determinants of myelin and axonal loss with aging","title_match":false,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/better-identification-of-cognitive-decline-with-interleukin-2-than-34122046","doi":"10.3389/fnagi.2021.670115","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"34122046","source_url":"https://pubmed.ncbi.nlm.nih.gov/34122046/","study_design":null,"title":"Better Identification of Cognitive Decline With Interleukin-2 Than With Amyloid and Tau Protein Biomarkers in Amnestic Mild Cognitive Impairment","title_match":false,"year":2021},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/plasma-total-prion-protein-as-a-potential-biomarker-for-31216593","doi":"10.1111/nan.12573","journal":"Neuropathology and applied neurobiology","n_participants":520,"pmid":"31216593","source_url":"https://pubmed.ncbi.nlm.nih.gov/31216593/","study_design":null,"title":"Plasma total prion protein as a potential biomarker for neurodegenerative dementia: diagnostic accuracy in the spectrum of prion diseases","title_match":false,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/discovering-and-targeting-the-basic-mechanism-of-neurodegeneration-23562497","doi":"10.1016/j.cbi.2013.03.015","journal":"Chemico-biological interactions","n_participants":null,"pmid":"23562497","source_url":"https://pubmed.ncbi.nlm.nih.gov/23562497/","study_design":null,"title":"Discovering and targeting the basic mechanism of neurodegeneration: the role of peptides from the C-terminus of acetylcholinesterase: non-hydrolytic effects of ache: the actions of peptides derived from the C-terminal and their relevance to neurodegeneration","title_match":false,"year":2013},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/alzheimer-s-pathology-is-associated-with-altered-cognition-brain-37480088","doi":"10.1186/s13195-023-01275-w","journal":"Alzheimer's research & therapy","n_participants":154,"pmid":"37480088","source_url":"https://pubmed.ncbi.nlm.nih.gov/37480088/","study_design":null,"title":"Alzheimer's pathology is associated with altered cognition, brain volume, and plasma biomarker patterns in traumatic encephalopathy syndrome","title_match":true,"year":2023},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/association-of-liver-disease-with-brain-volume-loss-cognitive-decline-36115133","doi":"10.1016/j.neurobiolaging.2022.08.004","journal":"Neurobiology of aging","n_participants":780,"pmid":"36115133","source_url":"https://pubmed.ncbi.nlm.nih.gov/36115133/","study_design":"longitudinal study","title":"Association of liver disease with brain volume loss, cognitive decline, and plasma neurodegenerative disease biomarkers","title_match":false,"year":2022},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/efficacy-and-safety-of-kami-guibi-tang-for-mild-cognitive-impairment-34620151","doi":"10.1186/s12906-021-03428-6","journal":"BMC complementary medicine and therapies","n_participants":16,"pmid":"34620151","source_url":"https://pubmed.ncbi.nlm.nih.gov/34620151/","study_design":null,"title":"Efficacy and safety of Kami-guibi-tang for mild cognitive impairment: a pilot, randomized, double-blind, placebo-controlled trial","title_match":false,"year":2021},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-and-alzheimer-s-disease-biomarkers-in-down-31156181","doi":"10.3233/jad-190322","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"31156181","source_url":"https://pubmed.ncbi.nlm.nih.gov/31156181/","study_design":null,"title":"Plasma Neurofilament Light and Alzheimer's Disease Biomarkers in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI)","title_match":false,"year":2019},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/preparedness-of-the-brazilian-health-care-system-to-provide-access-to-36063494","doi":"10.1002/alz.12778","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"36063494","source_url":"https://pubmed.ncbi.nlm.nih.gov/36063494/","study_design":null,"title":"Preparedness of the Brazilian health-care system to provide access to a disease-modifying Alzheimer's disease treatment","title_match":false,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/a-machine-learning-approach-to-identify-a-circulating-microrna-31811079","doi":"10.1373/jalm.2019.029595","journal":"The journal of applied laboratory medicine","n_participants":null,"pmid":"31811079","source_url":"https://pubmed.ncbi.nlm.nih.gov/31811079/","study_design":null,"title":"A Machine Learning Approach to Identify a Circulating MicroRNA Signature for Alzheimer Disease","title_match":false,"year":2020},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/frontal-variant-of-alzheimer-s-disease-with-asymmetric-presentation-31989779","doi":"10.1002/brb3.1548","journal":"Brain and behavior","n_participants":null,"pmid":"31989779","source_url":"https://pubmed.ncbi.nlm.nih.gov/31989779/","study_design":null,"title":"Frontal variant of Alzheimer's disease with asymmetric presentation mimicking frontotemporal dementia: Case report and literature review","title_match":false,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-potential-of-pathological-protein-fragmentation-in-blood-based-26029153","doi":"10.3389/fneur.2015.00090","journal":"Frontiers in neurology","n_participants":null,"pmid":"26029153","source_url":"https://pubmed.ncbi.nlm.nih.gov/26029153/","study_design":null,"title":"The potential of pathological protein fragmentation in blood-based biomarker development for dementia - with emphasis on Alzheimer's disease","title_match":true,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/reduced-levels-of-igm-autoantibodies-against-n-truncated-19781815","doi":"10.1016/j.neurobiolaging.2009.08.011","journal":"Neurobiology of aging","n_participants":null,"pmid":"19781815","source_url":"https://pubmed.ncbi.nlm.nih.gov/19781815/","study_design":null,"title":"Reduced levels of IgM autoantibodies against N-truncated pyroglutamate A\u03b2 in plasma of patients with Alzheimer's disease","title_match":false,"year":2011},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/ethnic-and-racial-influences-on-blood-biomarkers-for-alzheimer-s-39814528","doi":"10.1177/13872877241299047","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"39814528","source_url":"https://pubmed.ncbi.nlm.nih.gov/39814528/","study_design":"systematic review","title":"Ethnic and racial influences on blood biomarkers for Alzheimer's disease: A systematic review","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-of-neurodegeneration-associate-differently-with-38762725","doi":"10.1186/s13195-024-01477-w","journal":"Alzheimer's research & therapy","n_participants":19,"pmid":"38762725","source_url":"https://pubmed.ncbi.nlm.nih.gov/38762725/","study_design":null,"title":"Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE \u03b54-enriched cognitively unimpaired elderly","title_match":false,"year":2024},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/application-of-p7c3-compounds-to-investigating-and-treating-acute-and-37651054","doi":"10.1007/s13311-023-01427-8","journal":"Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics","n_participants":null,"pmid":"37651054","source_url":"https://pubmed.ncbi.nlm.nih.gov/37651054/","study_design":null,"title":"Application of P7C3 Compounds to Investigating and Treating Acute and Chronic Traumatic Brain Injury","title_match":false,"year":2023},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/classification-and-deep-learning-based-prediction-of-alzheimer-37386009","doi":"10.1038/s41398-023-02531-1","journal":"Translational psychiatry","n_participants":1947,"pmid":"37386009","source_url":"https://pubmed.ncbi.nlm.nih.gov/37386009/","study_design":null,"title":"Classification and deep-learning-based prediction of Alzheimer disease subtypes by using genomic data","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/preparedness-of-china-s-health-care-system-to-provide-access-to-a-37279385","doi":"10.1002/alz.13348","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37279385","source_url":"https://pubmed.ncbi.nlm.nih.gov/37279385/","study_design":null,"title":"Preparedness of China's health care system to provide access to a disease-modifying Alzheimer's treatment","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/involvement-of-the-chemokine-prokineticin-2-prok2-in-alzheimer-s-31766244","doi":"10.3390/cells8111430","journal":"Cells","n_participants":null,"pmid":"31766244","source_url":"https://pubmed.ncbi.nlm.nih.gov/31766244/","study_design":null,"title":"Involvement of the Chemokine Prokineticin-2 (PROK2) in Alzheimer's Disease: From Animal Models to the Human Pathology","title_match":false,"year":2019},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/nfl-strongly-correlates-with-tnf-r1-in-the-plasma-of-ad-patients-but-33986423","doi":"10.1038/s41598-021-89749-5","journal":"Scientific reports","n_participants":null,"pmid":"33986423","source_url":"https://pubmed.ncbi.nlm.nih.gov/33986423/","study_design":null,"title":"NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline","title_match":false,"year":2021},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/the-potential-emergence-of-disease-modifying-treatments-for-alzheimer-31704763","doi":"10.3122/jabfm.2019.06.180328","journal":"Journal of the American Board of Family Medicine : JABFM","n_participants":null,"pmid":"31704763","source_url":"https://pubmed.ncbi.nlm.nih.gov/31704763/","study_design":null,"title":"The Potential Emergence of Disease-Modifying Treatments for Alzheimer Disease: The Role of Primary Care in Managing the Patient Journey","title_match":false,"year":2019},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/slowly-progressive-behavioral-frontotemporal-dementia-with-c9orf72-29355451","doi":"10.1080/13554794.2018.1428353","journal":"Neurocase","n_participants":null,"pmid":"29355451","source_url":"https://pubmed.ncbi.nlm.nih.gov/29355451/","study_design":null,"title":"Slowly progressive behavioral frontotemporal dementia with C9orf72 mutation. Case report and review of the literature","title_match":false,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/identification-of-age-and-disease-related-alterations-in-circulating-25745387","doi":"10.3389/fncel.2015.00053","journal":"Frontiers in cellular neuroscience","n_participants":null,"pmid":"25745387","source_url":"https://pubmed.ncbi.nlm.nih.gov/25745387/","study_design":null,"title":"Identification of age- and disease-related alterations in circulating miRNAs in a mouse model of Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/higher-plasma-soluble-trem2-correlates-with-reduced-cerebral-tau-40169800","doi":"10.1038/s41380-025-02976-4","journal":"Molecular psychiatry","n_participants":129,"pmid":"40169800","source_url":"https://pubmed.ncbi.nlm.nih.gov/40169800/","study_design":null,"title":"Higher plasma soluble TREM2 correlates with reduced cerebral tau accumulation in Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/serum-neurofilament-indicates-accelerated-neurodegeneration-and-38195715","doi":"10.1038/s41531-023-00605-x","journal":"NPJ Parkinson's disease","n_participants":118,"pmid":"38195715","source_url":"https://pubmed.ncbi.nlm.nih.gov/38195715/","study_design":null,"title":"Serum neurofilament indicates accelerated neurodegeneration and predicts mortality in late-stage Parkinson's disease","title_match":false,"year":2024},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/the-role-of-glial-fibrillary-acidic-protein-in-the-neuropathology-of-40690136","doi":"10.1007/s12035-025-05219-3","journal":"Molecular neurobiology","n_participants":null,"pmid":"40690136","source_url":"https://pubmed.ncbi.nlm.nih.gov/40690136/","study_design":"longitudinal study","title":"The Role of Glial Fibrillary Acidic Protein in the Neuropathology of Alzheimer's Disease and Its Potential as a Blood Biomarker for Early Diagnosis and Progression","title_match":false,"year":2025},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/exploring-the-association-between-mild-behavioral-impairment-and-40406748","doi":"10.1002/dad2.70119","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":101,"pmid":"40406748","source_url":"https://pubmed.ncbi.nlm.nih.gov/40406748/","study_design":null,"title":"Exploring the association between mild behavioral impairment and plasma p-tau217: Implications for early detection of Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/ssris-reduce-plasma-tau-and-restore-dorsal-raphe-metabolism-in-39935329","doi":"10.1002/alz.14579","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":191,"pmid":"39935329","source_url":"https://pubmed.ncbi.nlm.nih.gov/39935329/","study_design":null,"title":"SSRIs reduce plasma tau and restore dorsal raphe metabolism in Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/white-matter-free-water-mediates-the-associations-between-placental-39692213","doi":"10.1002/alz.14408","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":370,"pmid":"39692213","source_url":"https://pubmed.ncbi.nlm.nih.gov/39692213/","study_design":null,"title":"White matter free water mediates the associations between placental growth factor, white matter hyperintensities, and cognitive status","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/peripheral-innate-immunophenotype-in-neurodegenerative-disease-blood-39472664","doi":"10.1038/s41380-024-02809-w","journal":"Molecular psychiatry","n_participants":148,"pmid":"39472664","source_url":"https://pubmed.ncbi.nlm.nih.gov/39472664/","study_design":null,"title":"Peripheral innate immunophenotype in neurodegenerative disease: blood-based profiles and links to survival","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/arteriolosclerosis-csvd-a-common-cause-of-dementia-and-stroke-and-its-37520130","doi":"10.3389/fnagi.2023.1163349","journal":"Frontiers in aging neuroscience","n_participants":146,"pmid":"37520130","source_url":"https://pubmed.ncbi.nlm.nih.gov/37520130/","study_design":null,"title":"Arteriolosclerosis CSVD: a common cause of dementia and stroke and its association with cognitive function and total MRI burden","title_match":false,"year":2023},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/fc-n-glycosylation-of-autoreactive-a-antibodies-as-a-blood-based-37260026","doi":"10.1002/alz.13124","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":40,"pmid":"37260026","source_url":"https://pubmed.ncbi.nlm.nih.gov/37260026/","study_design":null,"title":"Fc N-glycosylation of autoreactive A\u03b2 antibodies as a blood-based biomarker for Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/comparing-the-effects-of-olfactory-based-sensory-stimulation-and-36204759","doi":"10.3389/fpsyg.2022.1003325","journal":"Frontiers in psychology","n_participants":30,"pmid":"36204759","source_url":"https://pubmed.ncbi.nlm.nih.gov/36204759/","study_design":null,"title":"Comparing the effects of olfactory-based sensory stimulation and board game training on cognition, emotion, and blood biomarkers among individuals with dementia: A pilot randomized controlled trial","title_match":false,"year":2022},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/association-between-common-variants-of-apoe-abca7-a2m-bace1-and-34958020","doi":"10.3233/jad-215067","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"34958020","source_url":"https://pubmed.ncbi.nlm.nih.gov/34958020/","study_design":null,"title":"Association Between Common Variants of APOE, ABCA7, A2M, BACE1, and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease: Data from the PUMCH Dementia Cohort","title_match":false,"year":2022},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/the-potential-of-liquid-biopsy-of-the-brain-using-blood-extracellular-32975732","doi":"10.1007/s40291-020-00493-4","journal":"Molecular diagnosis & therapy","n_participants":null,"pmid":"32975732","source_url":"https://pubmed.ncbi.nlm.nih.gov/32975732/","study_design":null,"title":"The Potential of Liquid Biopsy of the Brain Using Blood Extracellular Vesicles: The First Step Toward Effective Neuroprotection Against Neurodegenerative Diseases","title_match":false,"year":2020},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/hypovitaminosis-d3-leukopenia-and-human-serotonin-transporter-26903713","doi":"10.1155/2016/8046479","journal":"Mediators of inflammation","n_participants":18,"pmid":"26903713","source_url":"https://pubmed.ncbi.nlm.nih.gov/26903713/","study_design":null,"title":"Hypovitaminosis D3, Leukopenia, and Human Serotonin Transporter Polymorphism in Anorexia Nervosa and Bulimia Nervosa","title_match":false,"year":2016},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/identify-biological-alzheimer-s-disease-using-a-novel-nucleic-acid-39845736","doi":"10.1093/braincomms/fcaf004","journal":"Brain communications","n_participants":397,"pmid":"39845736","source_url":"https://pubmed.ncbi.nlm.nih.gov/39845736/","study_design":null,"title":"Identify biological Alzheimer's disease using a novel nucleic acid-linked protein immunoassay","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/expected-wait-times-for-access-to-a-disease-modifying-alzheimer-s-37931615","doi":"10.1177/13558196231211141","journal":"Journal of health services research & policy","n_participants":null,"pmid":"37931615","source_url":"https://pubmed.ncbi.nlm.nih.gov/37931615/","study_design":null,"title":"Expected wait times for access to a disease-modifying Alzheimer's treatment in England: A modelling study","title_match":false,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/identification-of-plasma-proteins-as-biomarkers-for-mild-cognitive-37685872","doi":"10.3390/ijms241713064","journal":"International journal of molecular sciences","n_participants":192,"pmid":"37685872","source_url":"https://pubmed.ncbi.nlm.nih.gov/37685872/","study_design":null,"title":"Identification of Plasma Proteins as Biomarkers for Mild Cognitive Impairment and Alzheimer's Disease Using Liquid Chromatography-Tandem Mass Spectrometry","title_match":false,"year":2023},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/machine-learning-based-classification-of-subjective-cognitive-decline-36378559","doi":"10.1021/acschemneuro.2c00255","journal":"ACS chemical neuroscience","n_participants":206,"pmid":"36378559","source_url":"https://pubmed.ncbi.nlm.nih.gov/36378559/","study_design":null,"title":"Machine Learning-Based Classification of Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's Dementia Using Neuroimage and Plasma Biomarkers","title_match":true,"year":2022},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/a-conformational-variant-of-p53-u-p53az-as-blood-based-biomarker-for-35841248","doi":"10.14283/jpad.2022.52","journal":"The journal of prevention of Alzheimer's disease","n_participants":482,"pmid":"35841248","source_url":"https://pubmed.ncbi.nlm.nih.gov/35841248/","study_design":"longitudinal study","title":"A Conformational Variant of p53 (U-p53AZ) as Blood-Based Biomarker for the Prediction of the Onset of Symptomatic Alzheimer's Disease","title_match":true,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/circulatory-gsk-3-blood-based-biomarker-and-therapeutic-target-for-34776454","doi":"10.3233/jad-215347","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"34776454","source_url":"https://pubmed.ncbi.nlm.nih.gov/34776454/","study_design":null,"title":"Circulatory GSK-3\u03b2: Blood-Based Biomarker and Therapeutic Target for Alzheimer's Disease","title_match":true,"year":2022},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/methylomic-profiling-in-trisomy-21-identifies-cognition-and-alzheimer-31843015","doi":"10.1186/s13148-019-0787-x","journal":"Clinical epigenetics","n_participants":null,"pmid":"31843015","source_url":"https://pubmed.ncbi.nlm.nih.gov/31843015/","study_design":"longitudinal study","title":"Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer's disease-related dysregulation","title_match":false,"year":2019},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/two-novel-blood-based-biomarker-candidates-measuring-degradation-of-29641555","doi":"10.1371/journal.pone.0194802","journal":"PloS one","n_participants":null,"pmid":"29641555","source_url":"https://pubmed.ncbi.nlm.nih.gov/29641555/","study_design":"longitudinal study","title":"Two novel blood-based biomarker candidates measuring degradation of tau are associated with dementia: A prospective study","title_match":true,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/platelet-phosphorylated-tdp-43-an-exploratory-study-for-a-peripheral-29134122","doi":"10.4155/fsoa-2017-0090","journal":"Future science OA","n_participants":null,"pmid":"29134122","source_url":"https://pubmed.ncbi.nlm.nih.gov/29134122/","study_design":null,"title":"Platelet phosphorylated TDP-43: an exploratory study for a peripheral surrogate biomarker development for Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/population-pharmacokinetic-and-pharmacodynamic-analysis-of-plasma-a40-27129013","doi":"10.1002/cpdd.130","journal":"Clinical pharmacology in drug development","n_participants":null,"pmid":"27129013","source_url":"https://pubmed.ncbi.nlm.nih.gov/27129013/","study_design":null,"title":"Population pharmacokinetic and pharmacodynamic analysis of plasma A\u03b240 and A\u03b242 following single oral doses of the BACE1 inhibitor AZD3839 to healthy volunteers","title_match":true,"year":2014},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/biological-determinants-of-blood-based-biomarker-levels-in-alzheimer-41280310","doi":"10.3389/fnagi.2025.1614962","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"41280310","source_url":"https://pubmed.ncbi.nlm.nih.gov/41280310/","study_design":null,"title":"Biological determinants of blood-based biomarker levels in Alzheimer's disease: role of nutrition, inflammation, and metabolic factors","title_match":true,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/translational-disease-modeling-of-peripheral-blood-identifies-type-2-40442087","doi":"10.1038/s41540-025-00539-5","journal":"NPJ systems biology and applications","n_participants":null,"pmid":"40442087","source_url":"https://pubmed.ncbi.nlm.nih.gov/40442087/","study_design":null,"title":"Translational disease modeling of peripheral blood identifies type 2 diabetes biomarkers predictive of Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/prediction-of-longitudinal-synaptic-loss-in-alzheimer-s-disease-using-40432308","doi":"10.1002/alz.70333","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40432308","source_url":"https://pubmed.ncbi.nlm.nih.gov/40432308/","study_design":"longitudinal study","title":"Prediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers","title_match":true,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/cell-free-dna-as-peripheral-biomarker-of-alzheimer-s-disease-38607732","doi":"10.14336/ad.2024.0329","journal":"Aging and disease","n_participants":null,"pmid":"38607732","source_url":"https://pubmed.ncbi.nlm.nih.gov/38607732/","study_design":null,"title":"Cell-Free DNA As Peripheral Biomarker of Alzheimer's Disease","title_match":false,"year":2024},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/predictive-utility-of-plasma-amyloid-and-tau-for-cognitive-decline-in-36946444","doi":"10.14283/jpad.2023.15","journal":"The journal of prevention of Alzheimer's disease","n_participants":60,"pmid":"36946444","source_url":"https://pubmed.ncbi.nlm.nih.gov/36946444/","study_design":"longitudinal study","title":"Predictive Utility of Plasma Amyloid and Tau for Cognitive Decline in Cognitively Normal Adults","title_match":true,"year":2023},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/homocysteine-a-predictor-for-five-year-mortality-in-patients-with-36509298","doi":"10.1016/j.exger.2022.112045","journal":"Experimental gerontology","n_participants":null,"pmid":"36509298","source_url":"https://pubmed.ncbi.nlm.nih.gov/36509298/","study_design":null,"title":"Homocysteine - A predictor for five year-mortality in patients with subjective cognitive decline, mild cognitive impairment and Alzheimer's dementia","title_match":false,"year":2023},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-and-plasma-biomarkers-do-not-differ-in-the-32083577","doi":"10.3233/jad-190378","journal":"Journal of Alzheimer's disease : JAD","n_participants":44,"pmid":"32083577","source_url":"https://pubmed.ncbi.nlm.nih.gov/32083577/","study_design":null,"title":"Cerebrospinal Fluid and Plasma Biomarkers do not Differ in the Presenile and Late-Onset Behavioral Variants of Frontotemporal Dementia","title_match":true,"year":2020},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/erythrocytes-as-biomarkers-for-dementia-analysis-of-protein-content-31424413","doi":"10.3233/jad-190567","journal":"Journal of Alzheimer's disease : JAD","n_participants":114,"pmid":"31424413","source_url":"https://pubmed.ncbi.nlm.nih.gov/31424413/","study_design":null,"title":"Erythrocytes as Biomarkers for Dementia: Analysis of Protein Content and Alpha-Synuclein","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/blood-based-biomarker-screening-with-agnostic-biological-definitions-29512070","doi":"10.1007/978-1-4939-7704-8_9","journal":"Methods in molecular biology (Clifton, N.J.)","n_participants":null,"pmid":"29512070","source_url":"https://pubmed.ncbi.nlm.nih.gov/29512070/","study_design":null,"title":"Blood-Based Biomarker Screening with Agnostic Biological Definitions for an Accurate Diagnosis Within the Dimensional Spectrum of Neurodegenerative Diseases","title_match":true,"year":2018},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/prediction-of-amyloid-and-tau-brain-deposition-and-cognitive-decline-40541209","doi":"10.1016/s1474-4422(25)00158-9","journal":"The Lancet. Neurology","n_participants":220,"pmid":"40541209","source_url":"https://pubmed.ncbi.nlm.nih.gov/40541209/","study_design":"cohort study","title":"Prediction of amyloid and tau brain deposition and cognitive decline in people with Down syndrome using plasma biomarkers: a longitudinal cohort study","title_match":true,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/assessment-of-immunoprecipitation-with-subsequent-immunoassays-for-38316685","doi":"10.1007/s00406-023-01751-2","journal":"European archives of psychiatry and clinical neuroscience","n_participants":32,"pmid":"38316685","source_url":"https://pubmed.ncbi.nlm.nih.gov/38316685/","study_design":null,"title":"Assessment of immunoprecipitation with subsequent immunoassays for the blood-based diagnosis of Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/positive-association-between-plasmatic-levels-of-orexin-a-and-the-36466600","doi":"10.3389/fnagi.2022.1004002","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"36466600","source_url":"https://pubmed.ncbi.nlm.nih.gov/36466600/","study_design":null,"title":"Positive association between plasmatic levels of orexin A and the endocannabinoid-derived 2-arachidonoyl lysophosphatidic acid in Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-diagnosis-using-misfolding-proteins-in-blood-32174051","doi":"10.12779/dnd.2020.19.1.1","journal":"Dementia and neurocognitive disorders","n_participants":null,"pmid":"32174051","source_url":"https://pubmed.ncbi.nlm.nih.gov/32174051/","study_design":null,"title":"Alzheimer's Disease Diagnosis Using Misfolding Proteins in Blood","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/characterization-of-blood-surrogate-immune-methylation-biomarkers-for-31827492","doi":"10.3389/fgene.2019.01229","journal":"Frontiers in genetics","n_participants":null,"pmid":"31827492","source_url":"https://pubmed.ncbi.nlm.nih.gov/31827492/","study_design":null,"title":"Characterization of Blood Surrogate Immune-Methylation Biomarkers for Immune Cell Infiltration in Chronic Inflammaging Disorders","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/multivariate-platelet-analysis-differentiates-between-patients-with-31450503","doi":"10.3233/jad-190574","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"31450503","source_url":"https://pubmed.ncbi.nlm.nih.gov/31450503/","study_design":null,"title":"Multivariate Platelet Analysis Differentiates Between Patients with Alzheimer's Disease and Healthy Controls at First Clinical Diagnosis","title_match":false,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/progress-towards-a-consensus-on-biomarkers-for-alzheimer-s-disease-a-23905901","doi":"10.2217/bmm.13.59","journal":"Biomarkers in medicine","n_participants":null,"pmid":"23905901","source_url":"https://pubmed.ncbi.nlm.nih.gov/23905901/","study_design":null,"title":"Progress towards a consensus on biomarkers for Alzheimer's disease: a review of peripheral analytes","title_match":false,"year":2013},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/retinal-microvascular-alterations-in-alzheimer-s-disease-linking-41065118","doi":"10.1002/alz.70745","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":72,"pmid":"41065118","source_url":"https://pubmed.ncbi.nlm.nih.gov/41065118/","study_design":"cross-sectional","title":"Retinal microvascular alterations in Alzheimer's disease: Linking blood plasma biomarkers and cerebral small vessel pathology","title_match":true,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/multimodal-mri-reveals-impaired-glymphatic-function-with-choroid-40830653","doi":"10.1038/s41598-025-15923-8","journal":"Scientific reports","n_participants":188,"pmid":"40830653","source_url":"https://pubmed.ncbi.nlm.nih.gov/40830653/","study_design":null,"title":"Multimodal MRI reveals impaired glymphatic function with choroid plexus enlargement and cerebrospinal fluid expansion in alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/longitudinal-trajectory-of-plasma-p-tau217-in-cognitively-unimpaired-39702464","doi":"10.1186/s13195-024-01642-1","journal":"Alzheimer's research & therapy","n_participants":151,"pmid":"39702464","source_url":"https://pubmed.ncbi.nlm.nih.gov/39702464/","study_design":"longitudinal study","title":"Longitudinal trajectory of plasma p-tau217 in cognitively unimpaired subjects","title_match":true,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/high-affinity-antibodies-specific-to-the-core-region-of-the-tau-39358820","doi":"10.1186/s13195-024-01561-1","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"39358820","source_url":"https://pubmed.ncbi.nlm.nih.gov/39358820/","study_design":null,"title":"High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/effect-of-blood-collection-tube-containing-protease-inhibitors-on-the-38814273","doi":"10.1111/jnc.16130","journal":"Journal of neurochemistry","n_participants":null,"pmid":"38814273","source_url":"https://pubmed.ncbi.nlm.nih.gov/38814273/","study_design":null,"title":"Effect of blood collection tube containing protease inhibitors on the pre-analytical stability of Alzheimer's disease plasma biomarkers","title_match":true,"year":2024},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/recruiting-a-prospective-community-cohort-to-study-alzheimer-s-38756718","doi":"10.1002/trc2.12473","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":629,"pmid":"38756718","source_url":"https://pubmed.ncbi.nlm.nih.gov/38756718/","study_design":"longitudinal study","title":"Recruiting a prospective community cohort to study Alzheimer's disease and structural and social determinants of health among adults racialized as Black: The ARCHES cohort","title_match":false,"year":2024},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/estimation-of-cognitive-impairment-in-chronic-pain-patients-and-38523612","doi":"10.3389/fneur.2024.1344190","journal":"Frontiers in neurology","n_participants":114,"pmid":"38523612","source_url":"https://pubmed.ncbi.nlm.nih.gov/38523612/","study_design":null,"title":"Estimation of cognitive impairment in chronic pain patients and characteristics of estimated mild cognitive impairment","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/upregulated-blood-mir-150-5p-in-alzheimer-s-disease-dementia-is-35811521","doi":"10.3233/jad-220116","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"35811521","source_url":"https://pubmed.ncbi.nlm.nih.gov/35811521/","study_design":null,"title":"Upregulated Blood miR-150-5p in Alzheimer's Disease Dementia Is Associated with Cognition, Cerebrospinal Fluid Amyloid-\u03b2, and Cerebral Atrophy","title_match":false,"year":2022},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/relationship-of-amyloid-1-42-in-blood-and-brain-amyloid-ginkgo-31998865","doi":"10.1093/braincomms/fcz038","journal":"Brain communications","n_participants":160,"pmid":"31998865","source_url":"https://pubmed.ncbi.nlm.nih.gov/31998865/","study_design":"longitudinal study","title":"Relationship of amyloid-\u03b21-42 in blood and brain amyloid: Ginkgo Evaluation of Memory Study","title_match":false,"year":2020},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/risk-factors-of-behavioral-and-psychological-symptoms-in-patients-30369216","doi":"10.4082/kjfm.17.0061","journal":"Korean journal of family medicine","n_participants":1128,"pmid":"30369216","source_url":"https://pubmed.ncbi.nlm.nih.gov/30369216/","study_design":"cross-sectional","title":"Risk Factors of Behavioral and Psychological Symptoms in Patients with Alzheimer Disease: The Clinical Research of Dementia of South Korea Study","title_match":false,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/multivariate-analyses-of-peripheral-blood-leukocyte-transcripts-28716532","doi":"10.1016/j.neurobiolaging.2017.05.012","journal":"Neurobiology of aging","n_participants":null,"pmid":"28716532","source_url":"https://pubmed.ncbi.nlm.nih.gov/28716532/","study_design":null,"title":"Multivariate analyses of peripheral blood leukocyte transcripts distinguish Alzheimer's, Parkinson's, control, and those at risk for developing Alzheimer's","title_match":false,"year":2017},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/combined-assessment-of-serum-folate-and-hemoglobin-as-biomarkers-of-28406978","doi":"10.1371/journal.pone.0175854","journal":"PloS one","n_participants":null,"pmid":"28406978","source_url":"https://pubmed.ncbi.nlm.nih.gov/28406978/","study_design":null,"title":"Combined assessment of serum folate and hemoglobin as biomarkers of brain amyloid \u03b2 accumulation","title_match":false,"year":2017},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/platelet-membrane-secretase-activity-in-mild-cognitive-impairment-and-26639974","doi":"10.3233/jad-150795","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"26639974","source_url":"https://pubmed.ncbi.nlm.nih.gov/26639974/","study_design":"longitudinal study","title":"Platelet Membrane \u03b2-Secretase Activity in Mild Cognitive Impairment and Conversion to Dementia: a Longitudinal Study","title_match":false,"year":2016},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/attitudes-to-alzheimer-s-disease-testing-of-australian-general-26258761","doi":"10.1002/gps.4335","journal":"International journal of geriatric psychiatry","n_participants":489,"pmid":"26258761","source_url":"https://pubmed.ncbi.nlm.nih.gov/26258761/","study_design":"cross-sectional","title":"Attitudes to Alzheimer's disease testing of Australian general practice patients: a cross-sectional questionnaire-based study","title_match":false,"year":2016},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/association-between-brainage-and-alzheimer-s-disease-biomarkers-40018325","doi":"10.1002/dad2.70094","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"40018325","source_url":"https://pubmed.ncbi.nlm.nih.gov/40018325/","study_design":null,"title":"Association between BrainAGE and Alzheimer's disease biomarkers","title_match":false,"year":2025},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/plasma-p-tau181-and-gfap-reflect-7t-mr-derived-changes-in-alzheimer-s-39558898","doi":"10.1002/alz.14318","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":127,"pmid":"39558898","source_url":"https://pubmed.ncbi.nlm.nih.gov/39558898/","study_design":"longitudinal study","title":"Plasma p-tau181 and GFAP reflect 7T MR-derived changes in Alzheimer's disease: A longitudinal study of structural and functional MRI and MRS","title_match":true,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/performance-of-fully-automated-high-throughput-plasma-biomarker-39044519","doi":"10.14283/jpad.2024.58","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"39044519","source_url":"https://pubmed.ncbi.nlm.nih.gov/39044519/","study_design":null,"title":"Performance of Fully-Automated High-Throughput Plasma Biomarker Assays for Alzheimer's Disease in Amnestic Mild Cognitive Impairment Subjects","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/health-economic-considerations-in-the-deployment-of-an-alzheimer-s-38374736","doi":"10.14283/jpad.2024.23","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"38374736","source_url":"https://pubmed.ncbi.nlm.nih.gov/38374736/","study_design":null,"title":"Health Economic Considerations in the Deployment of an Alzheimer's Prevention Therapy","title_match":false,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/association-of-plasma-biomarkers-with-cognitive-function-in-persons-37954546","doi":"10.1002/dad2.12496","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"37954546","source_url":"https://pubmed.ncbi.nlm.nih.gov/37954546/","study_design":null,"title":"Association of plasma biomarkers with cognitive function in persons with dementia and cognitively healthy in the Democratic Republic of Congo","title_match":true,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/sex-specific-multiparameter-blood-test-for-the-early-diagnosis-of-36555310","doi":"10.3390/ijms232415670","journal":"International journal of molecular sciences","n_participants":null,"pmid":"36555310","source_url":"https://pubmed.ncbi.nlm.nih.gov/36555310/","study_design":"longitudinal study","title":"Sex-Specific Multiparameter Blood Test for the Early Diagnosis of Alzheimer's Disease","title_match":true,"year":2022},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/serum-levels-of-clusterin-pkr-and-rage-correlate-with-amyloid-burden-33646167","doi":"10.3233/jad-201443","journal":"Journal of Alzheimer's disease : JAD","n_participants":27,"pmid":"33646167","source_url":"https://pubmed.ncbi.nlm.nih.gov/33646167/","study_design":null,"title":"Serum Levels of Clusterin, PKR, and RAGE Correlate with Amyloid Burden in Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/is-korea-prepared-for-an-alzheimer-s-disease-modifying-therapy-33550774","doi":"10.4235/agmr.20.0082","journal":"Annals of geriatric medicine and research","n_participants":null,"pmid":"33550774","source_url":"https://pubmed.ncbi.nlm.nih.gov/33550774/","study_design":null,"title":"Is Korea Prepared for an Alzheimer's Disease-Modifying Therapy? Assessing the Korean Healthcare System Infrastructure and the Effect of Blood-Based Biomarker Tests","title_match":true,"year":2021},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/value-of-a-panel-of-6-serum-biomarkers-to-differentiate-between-32649324","doi":"10.1097/wad.0000000000000397","journal":"Alzheimer disease and associated disorders","n_participants":42,"pmid":"32649324","source_url":"https://pubmed.ncbi.nlm.nih.gov/32649324/","study_design":null,"title":"Value of a Panel of 6 Serum Biomarkers to Differentiate Between Healthy Controls and Mild Cognitive Impairment Due to Alzheimer Disease","title_match":true,"year":2020},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/an-exploration-of-the-oryza-sativa-l-cyanidin-3-glucoside-on-the-31558689","doi":"10.30773/pi.2019.06.17","journal":"Psychiatry investigation","n_participants":48,"pmid":"31558689","source_url":"https://pubmed.ncbi.nlm.nih.gov/31558689/","study_design":null,"title":"An Exploration of the Oryza sativa L. Cyanidin-3-glucoside on the Cognitive Function in Older Adults with Subjective Memory Impairment","title_match":false,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/potential-utility-of-soluble-p3-alcadein-plasma-levels-as-a-biomarker-22571980","doi":"10.3233/jad-2012-120601","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"22571980","source_url":"https://pubmed.ncbi.nlm.nih.gov/22571980/","study_design":null,"title":"Potential utility of soluble p3-alcadein \u03b1 plasma levels as a biomarker for sporadic Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/non-invasive-ultra-sensitive-high-throughput-assays-to-quantify-rare-18573345","doi":"10.1016/j.ymeth.2008.05.005","journal":"Methods (San Diego, Calif.)","n_participants":null,"pmid":"18573345","source_url":"https://pubmed.ncbi.nlm.nih.gov/18573345/","study_design":null,"title":"Non-invasive, ultra-sensitive, high-throughput assays to quantify rare biomarkers in the blood","title_match":false,"year":2008},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/melas-masquerading-as-a-systemic-vasculitis-18176143","doi":"10.1097/rhu.0b013e31815c2516","journal":"Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases","n_participants":null,"pmid":"18176143","source_url":"https://pubmed.ncbi.nlm.nih.gov/18176143/","study_design":null,"title":"MELAS masquerading as a systemic vasculitis","title_match":false,"year":2007},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/disclosure-of-alzheimer-s-disease-blood-based-biomarker-results-in-a-40713244","doi":"10.1016/j.tjpad.2025.100310","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"40713244","source_url":"https://pubmed.ncbi.nlm.nih.gov/40713244/","study_design":null,"title":"Disclosure of Alzheimer's disease blood-based biomarker results in a primary care setting: Opportunities and challenges","title_match":true,"year":2025},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/clinical-performance-of-the-fully-automated-lumipulse-plasma-p-tau217-39959359","doi":"10.1002/dad2.70080","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":148,"pmid":"39959359","source_url":"https://pubmed.ncbi.nlm.nih.gov/39959359/","study_design":null,"title":"Clinical performance of the fully automated Lumipulse plasma p-tau217 assay in mild cognitive impairment and mild dementia","title_match":true,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/clinical-utility-of-an-alzheimer-s-disease-blood-test-among-39857051","doi":"10.3390/diagnostics15020167","journal":"Diagnostics (Basel, Switzerland)","n_participants":203,"pmid":"39857051","source_url":"https://pubmed.ncbi.nlm.nih.gov/39857051/","study_design":null,"title":"Clinical Utility of an Alzheimer's Disease Blood Test Among Cognitively Impaired Patients: Results from the Quality Improvement PrecivityAD2 (QUIP II) Clinician Survey Study","title_match":true,"year":2025},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/exploring-the-ability-of-plasma-ptau217-ptau181-and-beta-amyloid-in-39838411","doi":"10.1186/s12987-025-00620-5","journal":"Fluids and barriers of the CNS","n_participants":306,"pmid":"39838411","source_url":"https://pubmed.ncbi.nlm.nih.gov/39838411/","study_design":null,"title":"Exploring the ability of plasma pTau217, pTau181 and beta-amyloid in mirroring cerebrospinal fluid biomarker profile of Mild Cognitive Impairment by the fully automated Lumipulse\u00ae platform","title_match":true,"year":2025},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/physical-function-is-associated-with-cognitive-status-brain-amyloid-39155519","doi":"10.1111/cns.14921","journal":"CNS neuroscience & therapeutics","n_participants":4189,"pmid":"39155519","source_url":"https://pubmed.ncbi.nlm.nih.gov/39155519/","study_design":null,"title":"Physical function is associated with cognitive status, brain amyloid-beta deposition, and blood biomarkers in Chinese Han population","title_match":false,"year":2024},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/relationship-between-topological-efficiency-of-white-matter-38224535","doi":"10.1002/hbm.26566","journal":"Human brain mapping","n_participants":null,"pmid":"38224535","source_url":"https://pubmed.ncbi.nlm.nih.gov/38224535/","study_design":"longitudinal study","title":"Relationship between topological efficiency of white matter structural connectome and plasma biomarkers across the Alzheimer's disease continuum","title_match":true,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/increased-oligomeric-tdp-43-in-the-plasma-of-korean-frontotemporal-37200243","doi":"10.1002/alz.13127","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":16,"pmid":"37200243","source_url":"https://pubmed.ncbi.nlm.nih.gov/37200243/","study_design":null,"title":"Increased oligomeric TDP-43 in the plasma of Korean frontotemporal dementia patients with semantic dementia","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-42-40-and-apolipoprotein-e-for-amyloid-pet-pre-36926368","doi":"10.1093/braincomms/fcad015","journal":"Brain communications","n_participants":null,"pmid":"36926368","source_url":"https://pubmed.ncbi.nlm.nih.gov/36926368/","study_design":null,"title":"Plasma amyloid-\u03b242/40 and apolipoprotein E for amyloid PET pre-screening in secondary prevention trials of Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/cyclic-glycine-proline-cgp-normalises-insulin-like-growth-factor-1-36770687","doi":"10.3390/molecules28031021","journal":"Molecules (Basel, Switzerland)","n_participants":null,"pmid":"36770687","source_url":"https://pubmed.ncbi.nlm.nih.gov/36770687/","study_design":null,"title":"Cyclic Glycine-Proline (cGP) Normalises Insulin-Like Growth Factor-1 (IGF-1) Function: Clinical Significance in the Ageing Brain and in Age-Related Neurological Conditions","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/a-public-resource-of-baseline-data-from-the-alzheimer-s-prevention-36373344","doi":"10.1002/alz.12843","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"36373344","source_url":"https://pubmed.ncbi.nlm.nih.gov/36373344/","study_design":null,"title":"A public resource of baseline data from the Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial","title_match":false,"year":2023},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/the-japan-multimodal-intervention-trial-for-prevention-of-dementia-36088747","doi":"10.1016/j.archger.2022.104803","journal":"Archives of gerontology and geriatrics","n_participants":200,"pmid":"36088747","source_url":"https://pubmed.ncbi.nlm.nih.gov/36088747/","study_design":"randomized controlled trial","title":"The Japan-Multimodal Intervention Trial for Prevention of Dementia PRIME Tamba (J-MINT PRIME Tamba): Study protocol of a randomised controlled multi-domain intervention trial","title_match":false,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/serum-neurofilament-light-in-patients-with-frontotemporal-dementia-33626531","doi":"10.1159/000513877","journal":"Dementia and geriatric cognitive disorders","n_participants":null,"pmid":"33626531","source_url":"https://pubmed.ncbi.nlm.nih.gov/33626531/","study_design":"cross-sectional","title":"Serum Neurofilament Light in Patients with Frontotemporal Dementia Caused by CHMP2B Mutation","title_match":false,"year":2020},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/early-detection-of-alzheimer-s-disease-and-dementia-prediction-in-32300816","doi":"10.1007/s00115-020-00907-y","journal":"Der Nervenarzt","n_participants":null,"pmid":"32300816","source_url":"https://pubmed.ncbi.nlm.nih.gov/32300816/","study_design":null,"title":"[Early detection of Alzheimer's disease and dementia prediction in patients with mild cognitive impairment : Summary of current recommendations]","title_match":false,"year":2020},{"alzhub_score":86,"alzhub_url":"https://alzhub.org/study/rates-of-screening-for-breast-colorectal-and-cervical-cancers-in-30246059","doi":"10.1177/2333721418799446","journal":"Gerontology & geriatric medicine","n_participants":18562,"pmid":"30246059","source_url":"https://pubmed.ncbi.nlm.nih.gov/30246059/","study_design":"meta-analysis","title":"Rates of Screening for Breast, Colorectal, and Cervical Cancers in Older People With Cognitive Impairment or Dementia: A Meta-Analysis","title_match":false,"year":2018},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/adherence-to-clinical-practice-guidelines-during-dementia-work-up-in-28697570","doi":"10.3233/jad-170284","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"28697570","source_url":"https://pubmed.ncbi.nlm.nih.gov/28697570/","study_design":null,"title":"Adherence to Clinical Practice Guidelines during Dementia Work-Up in a Real-World Setting: A Study from the Registry of Dementias of Girona","title_match":false,"year":2017},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/the-characteristics-of-camptocormia-in-patients-with-parkinson-s-26428310","doi":"10.1016/j.jns.2015.09.015","journal":"Journal of the neurological sciences","n_participants":null,"pmid":"26428310","source_url":"https://pubmed.ncbi.nlm.nih.gov/26428310/","study_design":"cross-sectional","title":"The characteristics of camptocormia in patients with Parkinson's disease: A large cross-sectional multicenter study in Japan","title_match":false,"year":2015},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/association-between-cell-bound-blood-amyloid-1-40-levels-and-25484928","doi":"10.1186/s13195-014-0056-3","journal":"Alzheimer's research & therapy","n_participants":96,"pmid":"25484928","source_url":"https://pubmed.ncbi.nlm.nih.gov/25484928/","study_design":"meta-analysis","title":"Association between cell-bound blood amyloid-\u03b2(1-40) levels and hippocampus volume","title_match":false,"year":2014},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/analytical-and-clinical-validation-of-a-high-accuracy-fully-automated-40708958","doi":"10.3389/fneur.2025.1568971","journal":"Frontiers in neurology","n_participants":null,"pmid":"40708958","source_url":"https://pubmed.ncbi.nlm.nih.gov/40708958/","study_design":null,"title":"Analytical and clinical validation of a high accuracy fully automated digital immunoassay for plasma phospho-Tau 217 for clinical use in detecting amyloid pathology","title_match":false,"year":2025},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/impact-of-cardiovascular-risk-factors-on-plasma-biomarkers-in-40506322","doi":"10.1016/j.tjpad.2025.100224","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"40506322","source_url":"https://pubmed.ncbi.nlm.nih.gov/40506322/","study_design":"case-control study","title":"Impact of cardiovascular risk factors on plasma biomarkers in prediction of Alzheimer's and cerebrovascular neuropathology","title_match":true,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-s100-is-a-predictor-for-pathology-and-cognitive-decline-in-39789614","doi":"10.1186/s12987-024-00615-8","journal":"Fluids and barriers of the CNS","n_participants":19,"pmid":"39789614","source_url":"https://pubmed.ncbi.nlm.nih.gov/39789614/","study_design":null,"title":"Plasma S100\u03b2 is a predictor for pathology and cognitive decline in Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/diagnosis-of-cognitive-impairment-and-dementia-blood-plasma-and-39749011","doi":"10.1093/braincomms/fcae472","journal":"Brain communications","n_participants":100,"pmid":"39749011","source_url":"https://pubmed.ncbi.nlm.nih.gov/39749011/","study_design":"cross-sectional","title":"Diagnosis of cognitive impairment and dementia: blood plasma and optical coherence tomography","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/the-association-of-alzheimer-s-disease-related-blood-based-biomarkers-38306056","doi":"10.3233/jad-230976","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"38306056","source_url":"https://pubmed.ncbi.nlm.nih.gov/38306056/","study_design":"cross-sectional","title":"The Association of Alzheimer's Disease-Related Blood-Based Biomarkers with Cognitive Screening Test Performance in the Congolese Population in Kinshasa","title_match":true,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/c-diadem-a-constrained-dual-input-deep-learning-model-to-identify-37833700","doi":"10.1186/s12920-023-01675-9","journal":"BMC medical genomics","n_participants":626,"pmid":"37833700","source_url":"https://pubmed.ncbi.nlm.nih.gov/37833700/","study_design":null,"title":"c-Diadem: a constrained dual-input deep learning model to identify novel biomarkers in Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/clinical-utility-of-an-antibody-free-lc-ms-method-to-detect-brain-37274930","doi":"10.1002/dad2.12451","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"37274930","source_url":"https://pubmed.ncbi.nlm.nih.gov/37274930/","study_design":null,"title":"Clinical utility of an antibody-free LC-MS method to detect brain amyloid deposition in cognitively unimpaired individuals from the screening visit of the A4 Study","title_match":false,"year":2023},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/parkinson-s-progression-markers-initiative-brain-autopsy-program-35803091","doi":"10.1016/j.parkreldis.2022.06.017","journal":"Parkinsonism & related disorders","n_participants":15,"pmid":"35803091","source_url":"https://pubmed.ncbi.nlm.nih.gov/35803091/","study_design":"longitudinal study","title":"Parkinson's Progression Markers Initiative brain autopsy program","title_match":false,"year":2022},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/analysis-of-plasma-proteins-using-2d-gels-and-novel-fluorescent-35081972","doi":"10.1186/s12953-021-00185-9","journal":"Proteome science","n_participants":null,"pmid":"35081972","source_url":"https://pubmed.ncbi.nlm.nih.gov/35081972/","study_design":null,"title":"Analysis of plasma proteins using 2D gels and novel fluorescent probes: in search of blood based biomarkers for Alzheimer's disease","title_match":true,"year":2022},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/investigation-of-the-number-of-tests-required-for-assaying-plasma-34515952","doi":"10.1007/s40120-021-00280-1","journal":"Neurology and therapy","n_participants":null,"pmid":"34515952","source_url":"https://pubmed.ncbi.nlm.nih.gov/34515952/","study_design":null,"title":"Investigation of the Number of Tests Required for Assaying Plasma Biomarkers Associated with Alzheimer's Disease Using Immunomagnetic Reduction","title_match":true,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/the-clinical-use-of-blood-test-factors-for-alzheimer-s-disease-34108650","doi":"10.1038/s12276-021-00638-3","journal":"Experimental & molecular medicine","n_participants":149,"pmid":"34108650","source_url":"https://pubmed.ncbi.nlm.nih.gov/34108650/","study_design":null,"title":"The clinical use of blood-test factors for Alzheimer's disease: improving the prediction of cerebral amyloid deposition by the QPLEXTM Alz plus assay kit","title_match":true,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/an-ensemble-method-for-diagnosis-of-parkinson-s-disease-based-on-31737550","doi":"10.4103/jmss.jmss_57_18","journal":"Journal of medical signals and sensors","n_participants":null,"pmid":"31737550","source_url":"https://pubmed.ncbi.nlm.nih.gov/31737550/","study_design":null,"title":"An Ensemble Method for Diagnosis of Parkinson's Disease Based on Voice Measurements","title_match":false,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/platelets-bioenergetics-screening-reflects-the-impact-of-brain-a-30357651","doi":"10.1007/s11064-018-2657-x","journal":"Neurochemical research","n_participants":null,"pmid":"30357651","source_url":"https://pubmed.ncbi.nlm.nih.gov/30357651/","study_design":null,"title":"Platelets Bioenergetics Screening Reflects the Impact of Brain A\u03b2 Plaque Accumulation in a Rat Model of Alzheimer","title_match":false,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/is-high-oral-dose-l-arginine-intake-effective-in-leukoaraiosis-23656351","doi":"10.2174/1874609811306020005","journal":"Current aging science","n_participants":null,"pmid":"23656351","source_url":"https://pubmed.ncbi.nlm.nih.gov/23656351/","study_design":null,"title":"Is high oral dose L-arginine intake effective in leukoaraiosis? Preliminary data, study protocol and expert's opinion","title_match":false,"year":2013},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-neuropathology-plasma-biomarkers-and-cognition-in-42208562","doi":"10.1016/s0140-6736(26)00515-5","journal":"Lancet (London, England)","n_participants":1500,"pmid":"42208562","source_url":"https://pubmed.ncbi.nlm.nih.gov/42208562/","study_design":"cohort study","title":"Alzheimer's disease neuropathology plasma biomarkers and cognition in midlife: a community-based cohort study","title_match":true,"year":2026},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/blood-based-biomarker-prescreening-with-different-testing-40065919","doi":"10.1002/trc2.70065","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":202,"pmid":"40065919","source_url":"https://pubmed.ncbi.nlm.nih.gov/40065919/","study_design":"cohort study","title":"Blood-based biomarker prescreening with different testing combinations and cutoffs: A simulation study examining efficacy and cost-effectiveness in Alzheimer's disease prevention studies","title_match":true,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-for-diagnosis-and-differentiation-and-their-40046335","doi":"10.1093/braincomms/fcaf094","journal":"Brain communications","n_participants":null,"pmid":"40046335","source_url":"https://pubmed.ncbi.nlm.nih.gov/40046335/","study_design":null,"title":"Plasma biomarkers for diagnosis and differentiation and their cognitive correlations in patients with Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/amino-terminally-elongated-a-peptides-are-generated-by-the-secreted-38867123","doi":"10.1111/nan.12991","journal":"Neuropathology and applied neurobiology","n_participants":null,"pmid":"38867123","source_url":"https://pubmed.ncbi.nlm.nih.gov/38867123/","study_design":null,"title":"Amino-terminally elongated A\u03b2 peptides are generated by the secreted metalloprotease ADAMTS4 and deposit in a subset of Alzheimer's disease brains","title_match":false,"year":2024},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/online-clinical-tools-to-support-the-use-of-new-plasma-biomarker-38090277","doi":"10.1093/braincomms/fcad322","journal":"Brain communications","n_participants":null,"pmid":"38090277","source_url":"https://pubmed.ncbi.nlm.nih.gov/38090277/","study_design":"narrative review","title":"Online clinical tools to support the use of new plasma biomarker diagnostic technology in the assessment of Alzheimer's disease: a narrative review","title_match":true,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/everyday-driving-and-plasma-biomarkers-in-alzheimer-s-disease-36938737","doi":"10.3233/jad-221268","journal":"Journal of Alzheimer's disease : JAD","n_participants":142,"pmid":"36938737","source_url":"https://pubmed.ncbi.nlm.nih.gov/36938737/","study_design":null,"title":"Everyday Driving and Plasma Biomarkers in Alzheimer's Disease: Leveraging Artificial Intelligence to Expand Our Diagnostic Toolkit","title_match":true,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/the-reliability-and-validity-of-dsm-5-diagnostic-criteria-for-34188117","doi":"10.1038/s41598-021-92887-5","journal":"Scientific reports","n_participants":165,"pmid":"34188117","source_url":"https://pubmed.ncbi.nlm.nih.gov/34188117/","study_design":null,"title":"The reliability and validity of DSM 5 diagnostic criteria for neurocognitive disorder and relationship with plasma neurofilament light in a down syndrome population","title_match":false,"year":2021},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/beyond-medical-actionability-public-perceptions-of-important-actions-30710467","doi":"10.1002/jgc4.1048","journal":"Journal of genetic counseling","n_participants":909,"pmid":"30710467","source_url":"https://pubmed.ncbi.nlm.nih.gov/30710467/","study_design":null,"title":"Beyond medical actionability: Public perceptions of important actions in response to hypothetical genetic testing results","title_match":false,"year":2019},{"alzhub_score":86,"alzhub_url":"https://alzhub.org/study/kidney-function-and-blood-and-cerebrospinal-fluid-biomarkers-in-41587095","doi":"10.1681/asn.0000001007","journal":"Journal of the American Society of Nephrology : JASN","n_participants":62503,"pmid":"41587095","source_url":"https://pubmed.ncbi.nlm.nih.gov/41587095/","study_design":"systematic review","title":"Kidney Function and Blood and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease and Related Dementias: Systematic Review and Meta-Analysis","title_match":false,"year":2026},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-for-alzheimer-s-disease-with-the-lumipulse-automated-39442787","doi":"10.1016/j.cca.2024.120014","journal":"Clinica chimica acta; international journal of clinical chemistry","n_participants":null,"pmid":"39442787","source_url":"https://pubmed.ncbi.nlm.nih.gov/39442787/","study_design":"cross-sectional","title":"Blood biomarkers for Alzheimer's disease with the Lumipulse automated platform: Age-effect and clinical value interpretation","title_match":false,"year":2025},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/storage-time-affects-the-level-and-diagnostic-efficacy-of-plasma-39359094","doi":"10.4103/nrr.nrr-d-23-01983","journal":"Neural regeneration research","n_participants":99,"pmid":"39359094","source_url":"https://pubmed.ncbi.nlm.nih.gov/39359094/","study_design":"cohort study","title":"Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/quantification-of-cox-2-level-in-alzheimer-s-disease-patients-to-38427490","doi":"10.3233/jad-231445","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"38427490","source_url":"https://pubmed.ncbi.nlm.nih.gov/38427490/","study_design":null,"title":"Quantification of COX-2 Level in Alzheimer's Disease Patients to Develop Potential Blood-Based Biomarker for Early Diagnosis and Therapeutic Target","title_match":true,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/merge-a-model-for-multi-input-biomedical-federated-learning-38035188","doi":"10.1016/j.patter.2023.100856","journal":"Patterns (New York, N.Y.)","n_participants":null,"pmid":"38035188","source_url":"https://pubmed.ncbi.nlm.nih.gov/38035188/","study_design":null,"title":"MERGE: A model for multi-input biomedical federated learning","title_match":false,"year":2023},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/remote-blood-collection-from-older-adults-in-the-brain-health-35226409","doi":"10.1002/alz.12617","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":7150,"pmid":"35226409","source_url":"https://pubmed.ncbi.nlm.nih.gov/35226409/","study_design":null,"title":"Remote blood collection from older adults in the Brain Health Registry for plasma biomarker and genetic analysis","title_match":true,"year":2022},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/covid-19-in-older-adults-retrospective-cohort-study-in-a-tertiary-32924229","doi":"10.1111/ggi.14034","journal":"Geriatrics & gerontology international","n_participants":null,"pmid":"32924229","source_url":"https://pubmed.ncbi.nlm.nih.gov/32924229/","study_design":null,"title":"COVID-19 in older adults: Retrospective cohort study in a tertiary hospital in Japan","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/expression-analysis-of-beta-secretase-1-bace1-enzyme-in-peripheral-31558988","doi":"10.22088/cjim.10.3.276","journal":"Caspian journal of internal medicine","n_participants":null,"pmid":"31558988","source_url":"https://pubmed.ncbi.nlm.nih.gov/31558988/","study_design":null,"title":"Expression analysis of beta-secretase 1 (BACE1) enzyme in peripheral blood of patients with Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/monocytes-exposed-to-plasma-from-patients-with-alzheimer-s-disease-30641113","doi":"10.1016/j.neures.2019.01.001","journal":"Neuroscience research","n_participants":null,"pmid":"30641113","source_url":"https://pubmed.ncbi.nlm.nih.gov/30641113/","study_design":null,"title":"Monocytes exposed to plasma from patients with Alzheimer's disease undergo metabolic reprogramming","title_match":false,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/identification-of-optimum-panel-of-blood-based-biomarkers-for-30441233","doi":"10.1109/embc.2018.8513293","journal":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","n_participants":null,"pmid":"30441233","source_url":"https://pubmed.ncbi.nlm.nih.gov/30441233/","study_design":null,"title":"Identification of Optimum Panel of Blood-based Biomarkers for Alzheimer's Disease Diagnosis Using Machine Learning","title_match":true,"year":2018},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-and-cognitive-impairment-evaluating-biomarker-equity-41767155","doi":"10.1002/dad2.70269","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":2798,"pmid":"41767155","source_url":"https://pubmed.ncbi.nlm.nih.gov/41767155/","study_design":null,"title":"Plasma p-tau217 and cognitive impairment: Evaluating biomarker equity across racial/ethnic groups in HABS-HD","title_match":true,"year":2026},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-for-alzheimer-s-disease-influence-of-kidney-41630037","doi":"10.1186/s13195-026-01970-4","journal":"Alzheimer's research & therapy","n_participants":112,"pmid":"41630037","source_url":"https://pubmed.ncbi.nlm.nih.gov/41630037/","study_design":null,"title":"Blood-based biomarkers for Alzheimer's disease: influence of kidney function","title_match":true,"year":2026},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/choroid-plexus-alterations-in-long-covid-and-their-associations-with-41612939","doi":"10.1002/alz.71020","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":86,"pmid":"41612939","source_url":"https://pubmed.ncbi.nlm.nih.gov/41612939/","study_design":null,"title":"Choroid plexus alterations in long COVID and their associations with Alzheimer's disease risks","title_match":false,"year":2026},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/glymphatic-dysfunction-links-vascular-pathology-to-alzheimer-s-41612483","doi":"10.1186/s13195-026-01964-2","journal":"Alzheimer's research & therapy","n_participants":1249,"pmid":"41612483","source_url":"https://pubmed.ncbi.nlm.nih.gov/41612483/","study_design":"longitudinal study","title":"Glymphatic dysfunction links vascular pathology to Alzheimer's biomarkers and cognitive decline","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/electrochemical-biosensors-combined-with-nanomaterial-signal-40920073","doi":"10.1021/acssensors.5c02453","journal":"ACS sensors","n_participants":null,"pmid":"40920073","source_url":"https://pubmed.ncbi.nlm.nih.gov/40920073/","study_design":null,"title":"Electrochemical Biosensors Combined with Nanomaterial Signal Amplification for the Detection of Alzheimer's Disease Biomarkers in Blood","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/assessing-diagnostic-performance-of-plasma-biomarkers-in-alzheimer-s-40207045","doi":"10.3389/fnagi.2025.1554805","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"40207045","source_url":"https://pubmed.ncbi.nlm.nih.gov/40207045/","study_design":null,"title":"Assessing diagnostic performance of plasma biomarkers in Alzheimer's disease versus cognitively unimpaired individuals: P-tau217 emerges as the optimal marker in Chinese cohorts","title_match":true,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/efficacy-of-lt-i-gt-ginkgo-biloba-lt-i-gt-as-an-adjunct-to-donepezil-40134691","doi":"10.3389/fneur.2025.1563056","journal":"Frontiers in neurology","n_participants":101,"pmid":"40134691","source_url":"https://pubmed.ncbi.nlm.nih.gov/40134691/","study_design":null,"title":"Efficacy of Ginkgo biloba as an adjunct to donepezil in amyloid PET-positive Alzheimer's patients","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/multiple-signal-amplification-strategy-to-fabricate-an-ultrasensitive-39835816","doi":"10.1021/acssensors.4c02916","journal":"ACS sensors","n_participants":null,"pmid":"39835816","source_url":"https://pubmed.ncbi.nlm.nih.gov/39835816/","study_design":null,"title":"Multiple-Signal Amplification Strategy to Fabricate an Ultrasensitive Electrochemiluminescence Magnetic Immunosensor for Detecting Biomarkers of Alzheimer's Disease via Iridium-Based Self-Enhancing Nanoemitters","title_match":false,"year":2025},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/the-impact-of-tau-pet-in-a-selected-memory-clinic-cohort-rationale-39427210","doi":"10.1186/s13195-024-01588-4","journal":"Alzheimer's research & therapy","n_participants":300,"pmid":"39427210","source_url":"https://pubmed.ncbi.nlm.nih.gov/39427210/","study_design":"longitudinal study","title":"The impact of tau-PET in a selected memory clinic cohort: rationale and design of the TAP-TAU study","title_match":false,"year":2024},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/the-alzmatch-pilot-study-feasibility-of-remote-blood-collection-of-39350391","doi":"10.14283/jpad.2024.101","journal":"The journal of prevention of Alzheimer's disease","n_participants":117,"pmid":"39350391","source_url":"https://pubmed.ncbi.nlm.nih.gov/39350391/","study_design":null,"title":"The AlzMatch Pilot Study - Feasibility of Remote Blood Collection of Plasma Biomarkers for Preclinical Alzheimer's Disease Trials","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/current-capacity-for-diagnosing-alzheimer-s-disease-in-germany-and-39302379","doi":"10.3233/jad-240728","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"39302379","source_url":"https://pubmed.ncbi.nlm.nih.gov/39302379/","study_design":null,"title":"Current Capacity for Diagnosing Alzheimer's Disease in Germany and Implications for Wait Times","title_match":false,"year":2024},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/impact-of-amyloid-and-cardiometabolic-risk-factors-on-prognostic-39267169","doi":"10.1186/s13195-024-01564-y","journal":"Alzheimer's research & therapy","n_participants":720,"pmid":"39267169","source_url":"https://pubmed.ncbi.nlm.nih.gov/39267169/","study_design":"longitudinal study","title":"Impact of amyloid and cardiometabolic risk factors on prognostic capacity of plasma neurofilament light chain for neurodegeneration","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/mirnas-and-stem-cells-as-promising-diagnostic-and-therapeutic-targets-37212107","doi":"10.3233/jad-221298","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"37212107","source_url":"https://pubmed.ncbi.nlm.nih.gov/37212107/","study_design":null,"title":"miRNAs and Stem Cells as Promising Diagnostic and Therapeutic Targets for Alzheimer's Disease","title_match":false,"year":2023},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/sleep-parameters-and-plasma-biomarkers-for-cognitive-impairment-36107008","doi":"10.1093/geronb/gbac137","journal":"The journals of gerontology. Series B, Psychological sciences and social sciences","n_participants":null,"pmid":"36107008","source_url":"https://pubmed.ncbi.nlm.nih.gov/36107008/","study_design":null,"title":"Sleep Parameters and Plasma Biomarkers for Cognitive Impairment Evaluation in Patients With Cerebral Small Vessel Disease","title_match":true,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/18-month-study-of-intravenous-immunoglobulin-for-treatment-of-mild-18294736","doi":"10.1016/j.neurobiolaging.2007.12.021","journal":"Neurobiology of aging","n_participants":null,"pmid":"18294736","source_url":"https://pubmed.ncbi.nlm.nih.gov/18294736/","study_design":null,"title":"18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease","title_match":false,"year":2009},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/blood-based-biomarkers-for-alzheimer-s-disease-current-state-and-37295421","doi":"10.1016/j.neuron.2023.05.017","journal":"Neuron","n_participants":null,"pmid":"37295421","source_url":"https://pubmed.ncbi.nlm.nih.gov/37295421/","study_design":null,"title":"Blood-based biomarkers for Alzheimer's disease: Current state and future use in a transformed global healthcare landscape","title_match":true,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/blood-based-molecular-biomarkers-for-alzheimer-s-disease-30922367","doi":"10.1186/s13041-019-0448-1","journal":"Molecular brain","n_participants":null,"pmid":"30922367","source_url":"https://pubmed.ncbi.nlm.nih.gov/30922367/","study_design":"narrative review","title":"Blood-based molecular biomarkers for Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/efns-ens-guidelines-on-the-diagnosis-and-management-of-disorders-22891773","doi":"10.1111/j.1468-1331.2012.03784.x","journal":"European journal of neurology","n_participants":null,"pmid":"22891773","source_url":"https://pubmed.ncbi.nlm.nih.gov/22891773/","study_design":"meta-analysis","title":"EFNS-ENS Guidelines on the diagnosis and management of disorders associated with dementia","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amyloid-beta-peptide-ratio-42-40-but-not-a-beta-42-correlates-with-17254013","doi":"10.1111/j.1471-4159.2006.04404.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"17254013","source_url":"https://pubmed.ncbi.nlm.nih.gov/17254013/","study_design":null,"title":"Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load","title_match":false,"year":2007},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/peripheral-abeta-subspecies-as-risk-biomarkers-of-alzheimer-s-disease-18779561","doi":"10.1073/pnas.0805902105","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"18779561","source_url":"https://pubmed.ncbi.nlm.nih.gov/18779561/","study_design":null,"title":"Peripheral Abeta subspecies as risk biomarkers of Alzheimer's disease","title_match":false,"year":2008},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/concurrent-detection-of-cognitive-impairment-and-amyloid-positivity-41382170","doi":"10.1186/s13195-025-01913-5","journal":"Alzheimer's research & therapy","n_participants":930,"pmid":"41382170","source_url":"https://pubmed.ncbi.nlm.nih.gov/41382170/","study_design":null,"title":"Concurrent detection of cognitive impairment and amyloid positivity with a multimodal machine learning-enabled digital cognitive assessment","title_match":false,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-blood-biomarkers-measured-through-remote-42091863","doi":"10.1038/s41467-026-71448-2","journal":"Nature communications","n_participants":174,"pmid":"42091863","source_url":"https://pubmed.ncbi.nlm.nih.gov/42091863/","study_design":null,"title":"Alzheimer's Disease blood biomarkers measured through remote capillary sampling correlate with cognition in older adults","title_match":false,"year":2026},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/predicting-brain-amyloid-load-with-digital-and-blood-based-biomarkers-40618175","doi":"10.1186/s13195-025-01801-y","journal":"Alzheimer's research & therapy","n_participants":349,"pmid":"40618175","source_url":"https://pubmed.ncbi.nlm.nih.gov/40618175/","study_design":null,"title":"Predicting brain amyloid load with digital and blood-based biomarkers","title_match":true,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/polygenic-risk-score-of-sporadic-late-onset-alzheimer-s-disease-28943286","doi":"10.1016/j.jalz.2017.08.013","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"28943286","source_url":"https://pubmed.ncbi.nlm.nih.gov/28943286/","study_design":null,"title":"Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms","title_match":false,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/biomarkers-in-sporadic-and-familial-alzheimer-s-disease-26401553","doi":"10.3233/jad-143006","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"26401553","source_url":"https://pubmed.ncbi.nlm.nih.gov/26401553/","study_design":null,"title":"Biomarkers in Sporadic and Familial Alzheimer's Disease","title_match":false,"year":2015},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/identification-of-genetic-risk-factors-in-the-chinese-population-29432188","doi":"10.1073/pnas.1715554115","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"29432188","source_url":"https://pubmed.ncbi.nlm.nih.gov/29432188/","study_design":null,"title":"Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer's disease pathogenesis","title_match":false,"year":2018},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/the-association-of-enlarged-perivascular-space-with-microglia-related-35577066","doi":"10.1016/j.nbd.2022.105755","journal":"Neurobiology of disease","n_participants":144,"pmid":"35577066","source_url":"https://pubmed.ncbi.nlm.nih.gov/35577066/","study_design":null,"title":"The association of enlarged perivascular space with microglia-related inflammation and Alzheimer's pathology in cognitively normal elderly","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/plasma-levels-of-soluble-trem2-and-neurofilament-light-chain-in-trem2-31779670","doi":"10.1186/s13195-019-0545-5","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"31779670","source_url":"https://pubmed.ncbi.nlm.nih.gov/31779670/","study_design":null,"title":"Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers","title_match":false,"year":2019},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-biomarkers-revisited-from-the-amyloid-cascade-35573283","doi":"10.3389/fnins.2022.837390","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"35573283","source_url":"https://pubmed.ncbi.nlm.nih.gov/35573283/","study_design":null,"title":"Alzheimer's Disease Biomarkers Revisited From the Amyloid Cascade Hypothesis Standpoint","title_match":false,"year":2022}]}