{"data_date":"2026-11-08","library_size":29380,"matched_against":"each record's title and abstract (summary field), case-insensitive","n":1711,"page":"https://alzhub.org/answers/apoe4-risk","query":"title or abstract mentions \"APOE4\", \"APOE \u03b54\", \"APOE e4\", \"\u03b54\", \"e4 allele/carrier\" or \"apolipoprotein E4\"","studies":[{"alzhub_score":14,"alzhub_url":"https://alzhub.org/study/fda-converts-novel-alzheimer-s-disease-treatment-to-traditional-826d45e8","doi":null,"journal":"U.S. Food and Drug Administration","n_participants":null,"pmid":null,"source_url":"https://www.fda.gov/news-events/press-announcements/fda-converts-novel-alzheimers-disease-treatment-traditional-approval","study_design":"regulatory decision","title":"FDA Converts Novel Alzheimer's Disease Treatment to Traditional Approval","title_match":false,"year":2023},{"alzhub_score":15,"alzhub_url":"https://alzhub.org/study/leqembi-recommended-for-treatment-of-early-alzheimer-s-disease-chmp-6280b4fa","doi":null,"journal":"European Medicines Agency","n_participants":null,"pmid":null,"source_url":"https://www.ema.europa.eu/en/news/leqembi-recommended-treatment-early-alzheimers-disease","study_design":"regulatory decision","title":"Leqembi Recommended for Treatment of Early Alzheimer's Disease (CHMP re-examination, reversing July 2024 refusal)","title_match":false,"year":2024},{"alzhub_score":15,"alzhub_url":"https://alzhub.org/study/kisunla-donanemab-eu-marketing-authorization-epar-following-chmp-re-87b2f0ae","doi":null,"journal":"European Medicines Agency","n_participants":null,"pmid":null,"source_url":"https://www.ema.europa.eu/en/medicines/human/EPAR/kisunla","study_design":"regulatory decision","title":"Kisunla (donanemab) \u2014 EU Marketing Authorization (EPAR), following CHMP re-examination","title_match":false,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/ucb-presents-data-on-bepranemab-anti-tau-antibody-in-early-alzheimer-c943abc5","doi":null,"journal":"UCB press release (data presented at CTAD 2024)","n_participants":466,"pmid":null,"source_url":"https://www.ucb.com/newsroom/press-releases/article/ucb-presents-encouraging-data-on-bepranemab-in-early-alzheimer-s-disease-in-phase-2a-study-at-ctad-2024","study_design":"phase-2-trial","title":"UCB Presents Data on Bepranemab (anti-tau antibody) in Early Alzheimer's Disease: Phase 2a TOGETHER Study","title_match":false,"year":2024},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/amyloid-related-imaging-abnormalities-aria-in-anti-amyloid-therapies-912127c4","doi":null,"journal":"Alzheimer's & Dementia","n_participants":null,"pmid":null,"source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13099593/","study_design":"systematic-review","title":"Amyloid-Related Imaging Abnormalities (ARIA) in Anti-Amyloid Therapies for Alzheimer's Disease: An Update from the Alzheimer's Association ARIA Workgroup","title_match":false,"year":2026},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/apoe4-homozygosity-represents-a-distinct-genetic-form-of-alzheimer-s-3b742ebe","doi":null,"journal":"Nature Medicine","n_participants":null,"pmid":null,"source_url":"https://www.nature.com/articles/s41591-024-02931-w","study_design":"cohort","title":"APOE4 homozygosity represents a distinct genetic form of Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":83,"alzhub_url":"https://alzhub.org/study/amyloid-related-imaging-abnormalities-with-donanemab-in-early-40063015","doi":"10.1001/jamaneurol.2025.0065","journal":"JAMA Neurology","n_participants":3030,"pmid":"40063015","source_url":"https://pubmed.ncbi.nlm.nih.gov/40063015/","study_design":"phase-3-trial","title":"Amyloid-Related Imaging Abnormalities With Donanemab in Early Symptomatic Alzheimer Disease: Secondary Analysis of the TRAILBLAZER-ALZ and ALZ 2 Randomized Clinical Trials","title_match":false,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/cost-effectiveness-of-lecanemab-for-individuals-with-early-stage-38484190","doi":"10.1212/WNL.0000000000209218","journal":"Neurology","n_participants":null,"pmid":"38484190","source_url":"https://pubmed.ncbi.nlm.nih.gov/38484190/","study_design":"modelling","title":"Cost-Effectiveness of Lecanemab for Individuals With Early-Stage Alzheimer Disease","title_match":false,"year":2024},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/consumption-of-olive-oil-and-diet-quality-and-risk-of-dementia-38709531","doi":"10.1001/jamanetworkopen.2024.10021","journal":"JAMA Network Open","n_participants":92383,"pmid":"38709531","source_url":"https://pubmed.ncbi.nlm.nih.gov/38709531/","study_design":"cohort","title":"Consumption of Olive Oil and Diet Quality and Risk of Dementia-Related Death","title_match":false,"year":2024},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/risk-factors-for-young-onset-dementia-in-the-uk-biobank-38147328","doi":"10.1001/jamaneurol.2023.4929","journal":"JAMA Neurology","n_participants":356052,"pmid":"38147328","source_url":"https://pubmed.ncbi.nlm.nih.gov/38147328/","study_design":"cohort","title":"Risk Factors for Young-Onset Dementia in the UK Biobank","title_match":false,"year":2024},{"alzhub_score":85,"alzhub_url":"https://alzhub.org/study/lifetime-risk-and-projected-burden-of-dementia-39806070","doi":"10.1038/s41591-024-03340-9","journal":"Nature Medicine","n_participants":15043,"pmid":"39806070","source_url":"https://pubmed.ncbi.nlm.nih.gov/39806070/","study_design":"cohort","title":"Lifetime risk and projected burden of dementia","title_match":false,"year":2025},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-217-and-incident-mild-cognitive-impairment-41805953","doi":"10.1001/jamanetworkopen.2026.1295","journal":"JAMA Network Open","n_participants":2766,"pmid":"41805953","source_url":"https://pubmed.ncbi.nlm.nih.gov/41805953/","study_design":"cohort","title":"Plasma Phosphorylated Tau 217 and Incident Mild Cognitive Impairment and Dementia in Older Women","title_match":false,"year":2026},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/impact-of-learning-apoe-genotype-on-cognitively-unimpaired-adults-a-41319675","doi":"10.1016/j.lanhl.2025.100778","journal":"The Lancet Healthy Longevity","n_participants":9496,"pmid":"41319675","source_url":"https://pubmed.ncbi.nlm.nih.gov/41319675/","study_design":"cohort","title":"Impact of learning APOE genotype on cognitively unimpaired adults: a pre-screening cohort study of the Alzheimer's Prevention Initiative Generation Study 1","title_match":false,"year":2025},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/apoe-and-alzheimer-s-disease-and-related-dementias-risk-among-12-221-40219824","doi":"10.1002/alz.70138","journal":"Alzheimer's & Dementia","n_participants":12221,"pmid":"40219824","source_url":"https://pubmed.ncbi.nlm.nih.gov/40219824/","study_design":"case-control","title":"APOE and Alzheimer's disease and related dementias risk among 12,221 Hispanics/Latinos","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/statin-initiation-and-risk-of-incident-alzheimer-disease-and-38447103","doi":"10.1212/WNL.0000000000209168","journal":"Neurology","n_participants":4807,"pmid":"38447103","source_url":"https://pubmed.ncbi.nlm.nih.gov/38447103/","study_design":"cohort","title":"Statin Initiation and Risk of Incident Alzheimer Disease and Cognitive Decline in Genetically Susceptible Older Adults","title_match":false,"year":2024},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/association-of-daily-driving-behaviors-with-mild-cognitive-impairment-41296993","doi":"10.1212/WNL.0000000000214440","journal":"Neurology","n_participants":298,"pmid":"41296993","source_url":"https://pubmed.ncbi.nlm.nih.gov/41296993/","study_design":"cohort","title":"Association of Daily Driving Behaviors With Mild Cognitive Impairment in Older Adults Followed Over 10 Years","title_match":false,"year":2025},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/the-relationship-of-omega-3-fatty-acids-with-dementia-and-cognitive-37028557","doi":"10.1016/j.ajcnut.2023.04.001","journal":"American Journal of Clinical Nutrition","n_participants":103651,"pmid":"37028557","source_url":"https://pubmed.ncbi.nlm.nih.gov/37028557/","study_design":"meta-analysis","title":"The Relationship of Omega-3 Fatty Acids with Dementia and Cognitive Decline: Evidence from Prospective Cohort Studies of Supplementation, Dietary Intake, and Blood Markers","title_match":false,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/associations-of-alcohol-drinking-with-incident-dementia-a-prospective-41014391","doi":"10.1007/s10654-025-01304-y","journal":"European Journal of Epidemiology","n_participants":296715,"pmid":"41014391","source_url":"https://pubmed.ncbi.nlm.nih.gov/41014391/","study_design":"cohort","title":"Associations of alcohol drinking with incident dementia: a prospective study from the UK Biobank","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/educational-attainment-and-dementia-mediation-by-mid-life-vascular-36966451","doi":"10.1002/ana.26647","journal":"Annals of Neurology","n_participants":13368,"pmid":"36966451","source_url":"https://pubmed.ncbi.nlm.nih.gov/36966451/","study_design":"cohort","title":"Educational Attainment and Dementia: Mediation by Mid-Life Vascular Risk Factors","title_match":false,"year":2023},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/cns-target-engagement-of-high-dose-dha-supplementation-in-older-42315445","doi":"10.1016/j.ebiom.2026.106316","journal":"EBioMedicine","n_participants":365,"pmid":"42315445","source_url":"https://pubmed.ncbi.nlm.nih.gov/42315445/","study_design":"phase-2-trial","title":"CNS target engagement of high-dose DHA supplementation in older adults at risk for dementia: a randomised, double-blind, placebo-controlled trial","title_match":false,"year":2026},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-217-concentrations-apoe-genotype-and-timing-42716078","doi":"10.1016/S1474-4422(26)00313-3","journal":"The Lancet. Neurology","n_participants":8582,"pmid":"42716078","source_url":"https://pubmed.ncbi.nlm.nih.gov/42716078/","study_design":"cohort","title":"Plasma phosphorylated tau 217 concentrations, APOE genotype, and timing of cognitive impairment in individuals across diverse racial and ethnic groups: a pooled analysis of prospective cohort studies","title_match":false,"year":2026},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/incidence-of-dementia-after-age-90-years-and-association-with-apoe-42551464","doi":"10.1016/j.lanhl.2026.100882","journal":"The lancet. Healthy longevity","n_participants":805,"pmid":"42551464","source_url":"https://pubmed.ncbi.nlm.nih.gov/42551464/","study_design":"cohort","title":"Incidence of dementia after age 90 years and association with APOE genotype, race, and sex in the USA: the LifeAfter90 prospective cohort study","title_match":false,"year":2026},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/cost-effectiveness-of-donanemab-for-early-alzheimer-disease-in-42015793","doi":"10.5694/mja2.70186","journal":"The Medical journal of Australia","n_participants":null,"pmid":"42015793","source_url":"https://pubmed.ncbi.nlm.nih.gov/42015793/","study_design":"modelling","title":"Cost-Effectiveness of Donanemab for Early Alzheimer Disease in Australia","title_match":false,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/cost-effectiveness-of-multimodal-intervention-for-the-prevention-of-41478834","doi":"10.1016/j.tjpad.2025.100460","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"41478834","source_url":"https://pubmed.ncbi.nlm.nih.gov/41478834/","study_design":"modelling","title":"Cost-effectiveness of multimodal intervention for the prevention of dementia in Japan","title_match":false,"year":2026},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/alzheimer-and-cardiovascular-genetic-scores-and-cognition-the-finger-40747850","doi":"10.1093/brain/awaf277","journal":"Brain : a journal of neurology","n_participants":1177,"pmid":"40747850","source_url":"https://pubmed.ncbi.nlm.nih.gov/40747850/","study_design":"RCT","title":"Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized controlled trial","title_match":false,"year":2026},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/sex-differences-in-amyloid-pathology-by-race-ancestry-and-41729539","doi":"10.1001/jamaneurol.2026.0054","journal":"JAMA neurology","n_participants":2268,"pmid":"41729539","source_url":"https://pubmed.ncbi.nlm.nih.gov/41729539/","study_design":"cross-sectional","title":"Sex Differences in Amyloid Pathology by Race, Ancestry, and Apolipoprotein E \u03b54 in an Admixed Autopsy Sample","title_match":true,"year":2026},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/association-of-african-ancestry-specific-apoe-missense-variant-r145c-36809323","doi":"10.1001/jama.2023.0268","journal":"JAMA","n_participants":31929,"pmid":"36809323","source_url":"https://pubmed.ncbi.nlm.nih.gov/36809323/","study_design":"case-control","title":"Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease","title_match":false,"year":2023},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/rare-genetic-variation-in-fibronectin-1-fn1-protects-against-apoe4-in-38598053","doi":"10.1007/s00401-024-02721-1","journal":"Acta Neuropathologica","n_participants":7185,"pmid":"38598053","source_url":"https://pubmed.ncbi.nlm.nih.gov/38598053/","study_design":"case-control","title":"Rare genetic variation in fibronectin 1 (FN1) protects against APOE\u03b54 in Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/validation-of-newly-derived-polygenic-risk-scores-for-dementia-in-a-37177856","doi":"10.1002/alz.13113","journal":"Alzheimer's & Dementia","n_participants":12031,"pmid":"37177856","source_url":"https://pubmed.ncbi.nlm.nih.gov/37177856/","study_design":"cohort","title":"Validation of newly derived polygenic risk scores for dementia in a prospective study of older individuals","title_match":false,"year":2023},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/polygenic-score-integrating-neurodegenerative-and-vascular-risk-40042447","doi":"10.1002/alz.70014","journal":"Alzheimer's & Dementia","n_participants":241935,"pmid":"40042447","source_url":"https://pubmed.ncbi.nlm.nih.gov/40042447/","study_design":"cohort","title":"Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/apoe-4-carriership-and-dementia-risk-over-10-years-among-asian-42427166","doi":"10.1002/alz.71615","journal":"Alzheimer's & Dementia","n_participants":46325,"pmid":"42427166","source_url":"https://pubmed.ncbi.nlm.nih.gov/42427166/","study_design":"cohort","title":"APOE-\u03b54 carriership and dementia risk over 10 years among Asian American and White older adults","title_match":true,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/aavrh-10-delivery-of-novel-apoe2-christchurch-variant-suppresses-39511891","doi":"10.1016/j.ymthe.2024.11.003","journal":"Molecular Therapy","n_participants":null,"pmid":"39511891","source_url":"https://pubmed.ncbi.nlm.nih.gov/39511891/","study_design":null,"title":"AAVrh.10 delivery of novel APOE2-Christchurch variant suppresses amyloid and Tau pathology in Alzheimer's disease mice","title_match":false,"year":2024},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/a-two-step-workflow-based-on-plasma-p-tau217-to-screen-for-amyloid-37653254","doi":"10.1038/s43587-023-00471-5","journal":"Nature Aging","n_participants":348,"pmid":"37653254","source_url":"https://pubmed.ncbi.nlm.nih.gov/37653254/","study_design":"cohort","title":"A two-step workflow based on plasma p-tau217 to screen for amyloid \u03b2 positivity with further confirmatory testing only in uncertain cases","title_match":false,"year":2023},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-217-to-identify-preclinical-alzheimer-40952756","doi":"10.1001/jamaneurol.2025.3217","journal":"JAMA Neurology","n_participants":2916,"pmid":"40952756","source_url":"https://pubmed.ncbi.nlm.nih.gov/40952756/","study_design":"cross-sectional","title":"Plasma Phosphorylated Tau 217 to Identify Preclinical Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/the-economic-burden-of-subjective-cognitive-decline-mild-cognitive-40571933","doi":"10.1186/s13195-025-01785-9","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"40571933","source_url":"https://pubmed.ncbi.nlm.nih.gov/40571933/","study_design":"cross-sectional","title":"The economic burden of subjective cognitive decline, mild cognitive impairment and Alzheimer's dementia: excess costs and associated clinical and risk factors","title_match":false,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/interplay-between-astrocyte-reactivity-and-apoe-4-status-is-41163175","doi":"10.1186/s13024-025-00906-0","journal":"Molecular Neurodegeneration","n_participants":806,"pmid":"41163175","source_url":"https://pubmed.ncbi.nlm.nih.gov/41163175/","study_design":"cohort","title":"Interplay between astrocyte reactivity and APOE \u03b54 status is associated with accelerated pTau-related tau pathology in Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/apoe4-lowers-the-ptau217-threshold-for-tau-aggregation-and-spread-in-41410687","doi":"10.1093/brain/awaf463","journal":"Brain","n_participants":401,"pmid":"41410687","source_url":"https://pubmed.ncbi.nlm.nih.gov/41410687/","study_design":"cohort","title":"ApoE4 lowers the ptau217 threshold for tau aggregation and spread in an allele dose-dependent manner","title_match":true,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apoe-stratified-genome-wide-association-analyses-provide-insights-42736378","doi":"10.1038/s41588-026-02713-9","journal":"Nature genetics","n_participants":null,"pmid":"42736378","source_url":"https://pubmed.ncbi.nlm.nih.gov/42736378/","study_design":"case-control","title":"APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease","title_match":false,"year":2026},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/a-common-19-bp-apoe-enhancer-deletion-is-protective-against-alzheimer-41629326","doi":"10.1038/s41467-026-68808-3","journal":"Nature Communications","n_participants":null,"pmid":"41629326","source_url":"https://pubmed.ncbi.nlm.nih.gov/41629326/","study_design":"case-control","title":"A common 19\u2009bp APOE enhancer deletion is protective against Alzheimer's disease in African Americans","title_match":false,"year":2026},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/proteomic-signatures-of-the-apoe-4-and-apoe-2-genetic-variants-and-42141098","doi":"10.1038/s43587-026-01123-0","journal":"Nature Aging","n_participants":null,"pmid":"42141098","source_url":"https://pubmed.ncbi.nlm.nih.gov/42141098/","study_design":"cohort","title":"Proteomic signatures of the APOE \u03b54 and APOE \u03b52 genetic variants and Alzheimer's disease","title_match":true,"year":2026},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/assessing-cognitive-decline-and-dementia-risk-in-black-and-white-41151002","doi":"10.1212/WNL.0000000000214317","journal":"Neurology","n_participants":1014,"pmid":"41151002","source_url":"https://pubmed.ncbi.nlm.nih.gov/41151002/","study_design":"cohort","title":"Assessing Cognitive Decline and Dementia Risk in Black and White Older Adults With Blood Biomarkers pTau217, GFAP, NfL, and A\u03b2 Ratio","title_match":false,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/electronic-health-records-to-test-multimorbidity-influences-to-plasma-41447112","doi":"10.1002/ana.78114","journal":"Annals of neurology","n_participants":617,"pmid":"41447112","source_url":"https://pubmed.ncbi.nlm.nih.gov/41447112/","study_design":"cross-sectional","title":"Electronic Health Records to Test Multimorbidity Influences to Plasma Biomarker Interpretation for Alzheimer's Disease","title_match":false,"year":2026},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/high-precision-plasma-amyloid-42-40-predicts-current-and-future-brain-31371569","doi":"10.1212/wnl.0000000000008081","journal":"Neurology","n_participants":null,"pmid":"31371569","source_url":"https://pubmed.ncbi.nlm.nih.gov/31371569/","study_design":null,"title":"High-precision plasma \u03b2-amyloid 42/40 predicts current and future brain amyloidosis","title_match":false,"year":2019},{"alzhub_score":82,"alzhub_url":"https://alzhub.org/study/prevalence-of-amyloid-pet-positivity-in-dementia-syndromes-a-meta-25988463","doi":"10.1001/jama.2015.4669","journal":"JAMA","n_participants":377,"pmid":"25988463","source_url":"https://pubmed.ncbi.nlm.nih.gov/25988463/","study_design":"meta-analysis","title":"Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis","title_match":false,"year":2015},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/age-sex-and-apoe-4-effects-on-memory-brain-structure-and-amyloid-25775353","doi":"10.1001/jamaneurol.2014.4821","journal":"JAMA neurology","n_participants":1246,"pmid":"25775353","source_url":"https://pubmed.ncbi.nlm.nih.gov/25775353/","study_design":"cross-sectional","title":"Age, Sex, and APOE \u03b54 Effects on Memory, Brain Structure, and \u03b2-Amyloid Across the Adult Life Span","title_match":true,"year":2015},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/association-of-factors-with-elevated-amyloid-burden-in-clinically-32250387","doi":"10.1001/jamaneurol.2020.0387","journal":"JAMA neurology","n_participants":4486,"pmid":"32250387","source_url":"https://pubmed.ncbi.nlm.nih.gov/32250387/","study_design":"cross-sectional","title":"Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals","title_match":false,"year":2020},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/plasma-glial-fibrillary-acidic-protein-detects-alzheimer-pathology-33773595","doi":"10.1186/s13195-021-00804-9","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"33773595","source_url":"https://pubmed.ncbi.nlm.nih.gov/33773595/","study_design":"longitudinal study","title":"Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive impairment","title_match":false,"year":2021},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/association-of-apolipoprotein-e-4-with-medial-temporal-tau-31860000","doi":"10.1001/jamaneurol.2019.4421","journal":"JAMA neurology","n_participants":124,"pmid":"31860000","source_url":"https://pubmed.ncbi.nlm.nih.gov/31860000/","study_design":"cross-sectional","title":"Association of Apolipoprotein E \u03b54 With Medial Temporal Tau Independent of Amyloid-\u03b2","title_match":true,"year":2020},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/validation-of-plasma-amyloid-42-40-for-detecting-alzheimer-disease-34906975","doi":"10.1212/wnl.0000000000013211","journal":"Neurology","n_participants":465,"pmid":"34906975","source_url":"https://pubmed.ncbi.nlm.nih.gov/34906975/","study_design":null,"title":"Validation of Plasma Amyloid-\u03b2 42/40 for Detecting Alzheimer Disease Amyloid Plaques","title_match":false,"year":2022},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-associated-with-the-apolipoprotein-e-genotype-and-22801723","doi":"10.1001/archneurol.2012.1070","journal":"Archives of neurology","n_participants":null,"pmid":"22801723","source_url":"https://pubmed.ncbi.nlm.nih.gov/22801723/","study_design":"cohort study","title":"Plasma biomarkers associated with the apolipoprotein E genotype and Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/diagnosis-across-the-spectrum-of-progressive-supranuclear-palsy-and-31860007","doi":"10.1001/jamaneurol.2019.4347","journal":"JAMA neurology","n_participants":76,"pmid":"31860007","source_url":"https://pubmed.ncbi.nlm.nih.gov/31860007/","study_design":"cohort study","title":"Diagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome","title_match":false,"year":2020},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/microarray-analysis-of-the-astrocyte-transcriptome-in-the-aging-brain-21705112","doi":"10.1016/j.neurobiolaging.2011.04.013","journal":"Neurobiology of aging","n_participants":null,"pmid":"21705112","source_url":"https://pubmed.ncbi.nlm.nih.gov/21705112/","study_design":null,"title":"Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype","title_match":false,"year":2011},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/selective-reduction-of-astrocyte-apoe3-and-apoe4-strongly-reduces-a-35109920","doi":"10.1186/s13024-022-00516-0","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"35109920","source_url":"https://pubmed.ncbi.nlm.nih.gov/35109920/","study_design":null,"title":"Selective reduction of astrocyte apoE3 and apoE4 strongly reduces A\u03b2 accumulation and plaque-related pathology in a mouse model of amyloidosis","title_match":true,"year":2022},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/association-of-i-apoe4-i-and-clinical-variability-in-alzheimer-33262228","doi":"10.1212/wnl.0000000000011270","journal":"Neurology","n_participants":119,"pmid":"33262228","source_url":"https://pubmed.ncbi.nlm.nih.gov/33262228/","study_design":null,"title":"Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET","title_match":true,"year":2021},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/spatial-temporal-patterns-of-amyloid-accumulation-a-subtype-and-stage-35292558","doi":"10.1212/wnl.0000000000200148","journal":"Neurology","n_participants":1890,"pmid":"35292558","source_url":"https://pubmed.ncbi.nlm.nih.gov/35292558/","study_design":null,"title":"Spatial-Temporal Patterns of \u03b2-Amyloid Accumulation: A Subtype and Stage Inference Model Analysis","title_match":false,"year":2022},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/amyloid-pet-screening-for-enrichment-of-early-stage-alzheimer-disease-26885819","doi":"10.1097/wad.0000000000000144","journal":"Alzheimer disease and associated disorders","n_participants":278,"pmid":"26885819","source_url":"https://pubmed.ncbi.nlm.nih.gov/26885819/","study_design":null,"title":"Amyloid PET Screening for Enrichment of Early-Stage Alzheimer Disease Clinical Trials: Experience in a Phase 1b Clinical Trial","title_match":false,"year":2016},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/csf-synaptic-biomarkers-in-the-preclinical-stage-of-alzheimer-disease-34556565","doi":"10.1212/wnl.0000000000012853","journal":"Neurology","n_participants":null,"pmid":"34556565","source_url":"https://pubmed.ncbi.nlm.nih.gov/34556565/","study_design":"cross-sectional","title":"CSF Synaptic Biomarkers in the Preclinical Stage of Alzheimer Disease and Their Association With MRI and PET: A Cross-sectional Study","title_match":false,"year":2021},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/plaque-associated-local-toxicity-increases-over-the-clinical-course-26687817","doi":"10.1016/j.ajpath.2015.10.010","journal":"The American journal of pathology","n_participants":null,"pmid":"26687817","source_url":"https://pubmed.ncbi.nlm.nih.gov/26687817/","study_design":null,"title":"Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease","title_match":false,"year":2016},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/frequency-of-biologically-defined-alzheimer-disease-in-relation-to-33443136","doi":"10.1212/wnl.0000000000011416","journal":"Neurology","n_participants":166,"pmid":"33443136","source_url":"https://pubmed.ncbi.nlm.nih.gov/33443136/","study_design":"cohort study","title":"Frequency of Biologically Defined Alzheimer Disease in Relation to Age, Sex, APOE \u03b54, and Cognitive Impairment","title_match":true,"year":2021},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/finding-treatment-effects-in-alzheimer-trials-in-the-face-of-disease-34550903","doi":"10.1212/wnl.0000000000012022","journal":"Neurology","n_participants":302,"pmid":"34550903","source_url":"https://pubmed.ncbi.nlm.nih.gov/34550903/","study_design":null,"title":"Finding Treatment Effects in Alzheimer Trials in the Face of Disease Progression Heterogeneity","title_match":false,"year":2021},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/apoe4-and-connectivity-mediated-spreading-of-tau-pathology-at-lower-37930695","doi":"10.1001/jamaneurol.2023.4038","journal":"JAMA neurology","n_participants":237,"pmid":"37930695","source_url":"https://pubmed.ncbi.nlm.nih.gov/37930695/","study_design":"cohort study","title":"ApoE4 and Connectivity-Mediated Spreading of Tau Pathology at Lower Amyloid Levels","title_match":true,"year":2023},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/association-of-aortic-stiffness-with-biomarkers-of-neuroinflammation-34031194","doi":"10.1212/wnl.0000000000012257","journal":"Neurology","n_participants":null,"pmid":"34031194","source_url":"https://pubmed.ncbi.nlm.nih.gov/34031194/","study_design":null,"title":"Association of Aortic Stiffness With Biomarkers of Neuroinflammation, Synaptic Dysfunction, and Neurodegeneration","title_match":false,"year":2021},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/associations-of-csf-pdgfr-with-aging-blood-brain-barrier-damage-37137722","doi":"10.1212/wnl.0000000000207358","journal":"Neurology","n_participants":408,"pmid":"37137722","source_url":"https://pubmed.ncbi.nlm.nih.gov/37137722/","study_design":null,"title":"Associations of CSF PDGFR\u03b2 With Aging, Blood-Brain Barrier Damage, Neuroinflammation, and Alzheimer Disease Pathologic Changes","title_match":false,"year":2023},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/sleep-24-hour-activity-rhythms-and-subsequent-amyloid-pathology-38913396","doi":"10.1001/jamaneurol.2024.1755","journal":"JAMA neurology","n_participants":639,"pmid":"38913396","source_url":"https://pubmed.ncbi.nlm.nih.gov/38913396/","study_design":"cohort study","title":"Sleep, 24-Hour Activity Rhythms, and Subsequent Amyloid-\u03b2 Pathology","title_match":false,"year":2024},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/population-variation-in-glial-fibrillary-acidic-protein-levels-in-19420941","doi":"10.1159/000217729","journal":"Dementia and geriatric cognitive disorders","n_participants":null,"pmid":"19420941","source_url":"https://pubmed.ncbi.nlm.nih.gov/19420941/","study_design":null,"title":"Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia","title_match":false,"year":2009},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-for-prediction-of-alzheimer-s-disease-37269398","doi":"10.1007/s00401-023-02594-w","journal":"Acta neuropathologica","n_participants":350,"pmid":"37269398","source_url":"https://pubmed.ncbi.nlm.nih.gov/37269398/","study_design":null,"title":"Plasma biomarkers for prediction of Alzheimer's disease neuropathologic change","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/atrophy-rates-in-asymptomatic-amyloidosis-implications-for-alzheimer-23554933","doi":"10.1371/journal.pone.0058816","journal":"PloS one","n_participants":null,"pmid":"23554933","source_url":"https://pubmed.ncbi.nlm.nih.gov/23554933/","study_design":null,"title":"Atrophy rates in asymptomatic amyloidosis: implications for Alzheimer prevention trials","title_match":false,"year":2013},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/biomarker-pattern-of-aria-e-participants-in-phase-3-randomized-29429971","doi":"10.1212/wnl.0000000000005060","journal":"Neurology","n_participants":1512,"pmid":"29429971","source_url":"https://pubmed.ncbi.nlm.nih.gov/29429971/","study_design":"longitudinal study","title":"Biomarker pattern of ARIA-E participants in phase 3 randomized clinical trials with bapineuzumab","title_match":false,"year":2018},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/can-studies-of-neuroinflammation-in-a-tspo-genetic-subgroup-hab-or-25840980","doi":"10.2967/jnumed.114.149443","journal":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","n_participants":798,"pmid":"25840980","source_url":"https://pubmed.ncbi.nlm.nih.gov/25840980/","study_design":"longitudinal study","title":"Can Studies of Neuroinflammation in a TSPO Genetic Subgroup (HAB or MAB) Be Applied to the Entire AD Cohort?","title_match":false,"year":2015},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/menopausal-vasomotor-symptoms-and-plasma-alzheimer-disease-biomarkers-37939982","doi":"10.1016/j.ajog.2023.11.002","journal":"American journal of obstetrics and gynecology","n_participants":274,"pmid":"37939982","source_url":"https://pubmed.ncbi.nlm.nih.gov/37939982/","study_design":null,"title":"Menopausal vasomotor symptoms and plasma Alzheimer disease biomarkers","title_match":false,"year":2024},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/plasma-tau-correlates-with-basal-forebrain-atrophy-rates-in-people-at-31801830","doi":"10.1212/wnl.0000000000008696","journal":"Neurology","n_participants":251,"pmid":"31801830","source_url":"https://pubmed.ncbi.nlm.nih.gov/31801830/","study_design":null,"title":"Plasma tau correlates with basal forebrain atrophy rates in people at risk for Alzheimer disease","title_match":false,"year":2020},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/association-of-dipeptidyl-peptidase-4-inhibitor-use-and-amyloid-34380754","doi":"10.1212/wnl.0000000000012534","journal":"Neurology","n_participants":70,"pmid":"34380754","source_url":"https://pubmed.ncbi.nlm.nih.gov/34380754/","study_design":"longitudinal study","title":"Association of Dipeptidyl Peptidase-4 Inhibitor Use and Amyloid Burden in Patients With Diabetes and AD-Related Cognitive Impairment","title_match":false,"year":2021},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/associations-of-stages-of-objective-memory-impairment-with-amyloid-35197359","doi":"10.1212/wnl.0000000000200046","journal":"Neurology","n_participants":null,"pmid":"35197359","source_url":"https://pubmed.ncbi.nlm.nih.gov/35197359/","study_design":null,"title":"Associations of Stages of Objective Memory Impairment With Amyloid PET and Structural MRI: The A4 Study","title_match":false,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/neuronal-pentraxin-1-a-synaptic-derived-plasma-biomarker-in-alzheimer-29501530","doi":"10.1016/j.nbd.2018.02.014","journal":"Neurobiology of disease","n_participants":null,"pmid":"29501530","source_url":"https://pubmed.ncbi.nlm.nih.gov/29501530/","study_design":null,"title":"Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/amyloid-pet-in-dementia-syndromes-a-chinese-multicenter-study-32385166","doi":"10.2967/jnumed.119.240325","journal":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","n_participants":null,"pmid":"32385166","source_url":"https://pubmed.ncbi.nlm.nih.gov/32385166/","study_design":null,"title":"Amyloid PET in Dementia Syndromes: A Chinese Multicenter Study","title_match":false,"year":2020},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/predicting-cognitive-decline-in-amyloid-positive-patients-with-mild-38986053","doi":"10.1212/wnl.0000000000209605","journal":"Neurology","n_participants":961,"pmid":"38986053","source_url":"https://pubmed.ncbi.nlm.nih.gov/38986053/","study_design":"longitudinal study","title":"Predicting Cognitive Decline in Amyloid-Positive Patients With Mild Cognitive Impairment or Mild Dementia","title_match":false,"year":2024},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-total-tau-and-neurofilament-light-chain-levels-and-the-35232820","doi":"10.1212/wnl.0000000000200004","journal":"Neurology","n_participants":379,"pmid":"35232820","source_url":"https://pubmed.ncbi.nlm.nih.gov/35232820/","study_design":null,"title":"Plasma \u03b2-Amyloid, Total-Tau, and Neurofilament Light Chain Levels and the Risk of Stroke: A Prospective Population-Based Study","title_match":false,"year":2022},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/association-of-plasma-biomarkers-with-longitudinal-atrophy-and-40063856","doi":"10.1212/wnl.0000000000213438","journal":"Neurology","n_participants":1240,"pmid":"40063856","source_url":"https://pubmed.ncbi.nlm.nih.gov/40063856/","study_design":"cohort study","title":"Association of Plasma Biomarkers With Longitudinal Atrophy and Microvascular Burden on MRI Across Neurodegenerative and Cerebrovascular Diseases","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/onset-of-preclinical-alzheimer-disease-in-monozygotic-twins-33583080","doi":"10.1002/ana.26048","journal":"Annals of neurology","n_participants":126,"pmid":"33583080","source_url":"https://pubmed.ncbi.nlm.nih.gov/33583080/","study_design":null,"title":"Onset of Preclinical Alzheimer Disease in Monozygotic Twins","title_match":false,"year":2021},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/cognitively-normal-apoe-4-carriers-have-specific-elevation-of-csf-33765432","doi":"10.1016/j.neurobiolaging.2021.02.008","journal":"Neurobiology of aging","n_participants":274,"pmid":"33765432","source_url":"https://pubmed.ncbi.nlm.nih.gov/33765432/","study_design":null,"title":"Cognitively normal APOE \u03b54 carriers have specific elevation of CSF SNAP-25","title_match":true,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/associations-of-microbleeds-and-their-topography-with-imaging-and-csf-39074338","doi":"10.1212/wnl.0000000000209676","journal":"Neurology","n_participants":276,"pmid":"39074338","source_url":"https://pubmed.ncbi.nlm.nih.gov/39074338/","study_design":"cross-sectional","title":"Associations of Microbleeds and Their Topography With Imaging and CSF Biomarkers of Alzheimer Pathology in Individuals With Down Syndrome","title_match":false,"year":2024},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/csf-biomarkers-in-olmsted-county-evidence-of-2-subclasses-and-32591471","doi":"10.1212/wnl.0000000000009874","journal":"Neurology","n_participants":547,"pmid":"32591471","source_url":"https://pubmed.ncbi.nlm.nih.gov/32591471/","study_design":null,"title":"CSF biomarkers in Olmsted County: Evidence of 2 subclasses and associations with demographics","title_match":false,"year":2020},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/aerobic-exercise-does-not-affect-serum-neurofilament-light-in-36761410","doi":"10.3389/fnins.2023.1108191","journal":"Frontiers in neuroscience","n_participants":136,"pmid":"36761410","source_url":"https://pubmed.ncbi.nlm.nih.gov/36761410/","study_design":null,"title":"Aerobic exercise does not affect serum neurofilament light in patients with mild Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/hippocampal-volume-loss-brain-amyloid-accumulation-and-apoe-status-in-31846965","doi":"10.1159/000504302","journal":"Neuro-degenerative diseases","n_participants":null,"pmid":"31846965","source_url":"https://pubmed.ncbi.nlm.nih.gov/31846965/","study_design":"longitudinal study","title":"Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects","title_match":false,"year":2019},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/tnfr-1-and-gdf-15-are-associated-with-plasma-neurofilament-light-36508390","doi":"10.1093/gerona/glac244","journal":"The journals of gerontology. Series A, Biological sciences and medical sciences","n_participants":116,"pmid":"36508390","source_url":"https://pubmed.ncbi.nlm.nih.gov/36508390/","study_design":"cross-sectional","title":"TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study","title_match":false,"year":2023},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/atrophy-patterns-in-cerebral-amyloid-angiopathy-with-and-without-29678935","doi":"10.1212/wnl.0000000000005524","journal":"Neurology","n_participants":27,"pmid":"29678935","source_url":"https://pubmed.ncbi.nlm.nih.gov/29678935/","study_design":null,"title":"Atrophy patterns in cerebral amyloid angiopathy with and without cortical superficial siderosis","title_match":false,"year":2018},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/effect-of-obicetrapib-a-potent-cholesteryl-ester-transfer-protein-41109840","doi":"10.1016/j.tjpad.2025.100394","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"41109840","source_url":"https://pubmed.ncbi.nlm.nih.gov/41109840/","study_design":"clinical trial","title":"Effect of obicetrapib, a potent cholesteryl ester transfer protein inhibitor, on p-tau217 levels in patients with cardiovascular disease","title_match":false,"year":2026},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/advanced-structural-brain-aging-in-preclinical-autosomal-dominant-38111006","doi":"10.1186/s13024-023-00688-3","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"38111006","source_url":"https://pubmed.ncbi.nlm.nih.gov/38111006/","study_design":null,"title":"Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease","title_match":false,"year":2023},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/integrating-plasma-p-tau217-and-digital-cognitive-assessments-for-40491259","doi":"10.1002/alz.70355","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":954,"pmid":"40491259","source_url":"https://pubmed.ncbi.nlm.nih.gov/40491259/","study_design":null,"title":"Integrating plasma p-tau217 and digital cognitive assessments for early detection in Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/evidence-of-pericyte-damage-in-a-cognitively-normal-cohort-38752577","doi":"10.1097/wad.0000000000000623","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"38752577","source_url":"https://pubmed.ncbi.nlm.nih.gov/38752577/","study_design":"cross-sectional","title":"Evidence of Pericyte Damage in a Cognitively Normal Cohort: Association With CSF and PET Biomarkers of Alzheimer Disease","title_match":false,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/demographic-and-clinical-characteristics-associated-with-serum-gfap-37813589","doi":"10.1212/wnl.0000000000207706","journal":"Neurology","n_participants":1156,"pmid":"37813589","source_url":"https://pubmed.ncbi.nlm.nih.gov/37813589/","study_design":null,"title":"Demographic and Clinical Characteristics Associated With Serum GFAP Levels in an Ethnically Diverse Cohort","title_match":false,"year":2023},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/sex-differences-in-the-associations-of-obesity-with-tau-amyloid-pet-37574737","doi":"10.3233/jad-230466","journal":"Journal of Alzheimer's disease : JAD","n_participants":387,"pmid":"37574737","source_url":"https://pubmed.ncbi.nlm.nih.gov/37574737/","study_design":null,"title":"Sex Differences in the Associations of Obesity with Tau, Amyloid PET, and Cognitive Outcomes in Preclinical Alzheimer's Disease: Cross-Sectional A4 Study","title_match":false,"year":2023},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/low-circulating-adropin-concentrations-predict-increased-risk-of-37233882","doi":"10.1007/s11357-023-00824-3","journal":"GeroScience","n_participants":452,"pmid":"37233882","source_url":"https://pubmed.ncbi.nlm.nih.gov/37233882/","study_design":null,"title":"Low circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adults","title_match":false,"year":2024},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/association-of-enlarged-perivascular-spaces-with-early-serum-and-40845262","doi":"10.1212/wnl.0000000000213836","journal":"Neurology","n_participants":979,"pmid":"40845262","source_url":"https://pubmed.ncbi.nlm.nih.gov/40845262/","study_design":"cross-sectional","title":"Association of Enlarged Perivascular Spaces With Early Serum and Neuroimaging Biomarkers of Alzheimer Disease Pathology","title_match":false,"year":2025},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/effects-of-age-sex-and-ethnicity-on-the-association-between-9343467","doi":"10.1001/jama.1997.03550160069041","journal":"JAMA","n_participants":5930,"pmid":"9343467","source_url":"https://pubmed.ncbi.nlm.nih.gov/9343467/","study_design":null,"title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","title_match":false,"year":1997},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-high-avidity-binding-to-beta-amyloid-and-increased-8446617","doi":"10.1073/pnas.90.5.1977","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"8446617","source_url":"https://pubmed.ncbi.nlm.nih.gov/8446617/","study_design":null,"title":"Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease","title_match":false,"year":1993},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-alzheimer-disease-risk-mechanisms-and-therapy-23296339","doi":"10.1038/nrneurol.2012.263","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"23296339","source_url":"https://pubmed.ncbi.nlm.nih.gov/23296339/","study_design":null,"title":"Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy","title_match":false,"year":2013},{"alzhub_score":85,"alzhub_url":"https://alzhub.org/study/two-phase-3-trials-of-bapineuzumab-in-mild-to-moderate-alzheimer-s-24450891","doi":"10.1056/nejmoa1304839","journal":"The New England journal of medicine","n_participants":1090,"pmid":"24450891","source_url":"https://pubmed.ncbi.nlm.nih.gov/24450891/","study_design":"clinical trial","title":"Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/oxidative-damage-is-the-earliest-event-in-alzheimer-disease-11487050","doi":"10.1093/jnen/60.8.759","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"11487050","source_url":"https://pubmed.ncbi.nlm.nih.gov/11487050/","study_design":null,"title":"Oxidative damage is the earliest event in Alzheimer disease","title_match":false,"year":2001},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-alzheimer-disease-pathobiology-and-targeting-31367008","doi":"10.1038/s41582-019-0228-7","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"31367008","source_url":"https://pubmed.ncbi.nlm.nih.gov/31367008/","study_design":null,"title":"Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies","title_match":false,"year":2019},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/apoe4-markedly-exacerbates-tau-mediated-neurodegeneration-in-a-mouse-28959956","doi":"10.1038/nature24016","journal":"Nature","n_participants":null,"pmid":"28959956","source_url":"https://pubmed.ncbi.nlm.nih.gov/28959956/","study_design":null,"title":"ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy","title_match":true,"year":2017},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/increased-amyloid-beta-peptide-deposition-in-cerebral-cortex-as-a-8415756","doi":"10.1073/pnas.90.20.9649","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"8415756","source_url":"https://pubmed.ncbi.nlm.nih.gov/8415756/","study_design":null,"title":"Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease","title_match":false,"year":1993},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/binding-of-human-apolipoprotein-e-to-synthetic-amyloid-beta-peptide-8367470","doi":"10.1073/pnas.90.17.8098","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"8367470","source_url":"https://pubmed.ncbi.nlm.nih.gov/8367470/","study_design":null,"title":"Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease","title_match":false,"year":1993},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/cognitive-decline-in-parkinson-disease-28257128","doi":"10.1038/nrneurol.2017.27","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"28257128","source_url":"https://pubmed.ncbi.nlm.nih.gov/28257128/","study_design":"longitudinal study","title":"Cognitive decline in Parkinson disease","title_match":false,"year":2017},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/the-preclinical-alzheimer-cognitive-composite-measuring-amyloid-24886908","doi":"10.1001/jamaneurol.2014.803","journal":"JAMA neurology","n_participants":null,"pmid":"24886908","source_url":"https://pubmed.ncbi.nlm.nih.gov/24886908/","study_design":null,"title":"The preclinical Alzheimer cognitive composite: measuring amyloid-related decline","title_match":false,"year":2014},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/sex-modifies-the-apoe-related-risk-of-developing-alzheimer-disease-24623176","doi":"10.1002/ana.24135","journal":"Annals of neurology","n_participants":5496,"pmid":"24623176","source_url":"https://pubmed.ncbi.nlm.nih.gov/24623176/","study_design":"case-control study","title":"Sex modifies the APOE-related risk of developing Alzheimer disease","title_match":false,"year":2014},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/imaging-beta-amyloid-burden-in-aging-and-dementia-17502554","doi":"10.1212/01.wnl.0000261919.22630.ea","journal":"Neurology","n_participants":null,"pmid":"17502554","source_url":"https://pubmed.ncbi.nlm.nih.gov/17502554/","study_design":"longitudinal study","title":"Imaging beta-amyloid burden in aging and dementia","title_match":false,"year":2007},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/increased-hippocampal-activation-in-mild-cognitive-impairment-16087905","doi":"10.1212/01.wnl.0000171450.97464.49","journal":"Neurology","n_participants":null,"pmid":"16087905","source_url":"https://pubmed.ncbi.nlm.nih.gov/16087905/","study_design":null,"title":"Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD","title_match":false,"year":2005},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/apoe-predicts-amyloid-beta-but-not-tau-alzheimer-pathology-in-20186853","doi":"10.1002/ana.21843","journal":"Annals of neurology","n_participants":241,"pmid":"20186853","source_url":"https://pubmed.ncbi.nlm.nih.gov/20186853/","study_design":null,"title":"APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging","title_match":false,"year":2010},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-apolipoprotein-e-receptors-normal-biology-and-22393530","doi":"10.1101/cshperspect.a006312","journal":"Cold Spring Harbor perspectives in medicine","n_participants":null,"pmid":"22393530","source_url":"https://pubmed.ncbi.nlm.nih.gov/22393530/","study_design":null,"title":"Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/longitudinal-assessment-of-a-and-cognition-in-aging-and-alzheimer-21280088","doi":"10.1002/ana.22248","journal":"Annals of neurology","n_participants":206,"pmid":"21280088","source_url":"https://pubmed.ncbi.nlm.nih.gov/21280088/","study_design":null,"title":"Longitudinal assessment of A\u03b2 and cognition in aging and Alzheimer disease","title_match":false,"year":2011},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/apoe-isoform-specific-disruption-of-amyloid-beta-peptide-clearance-19033669","doi":"10.1172/jci36663","journal":"The Journal of clinical investigation","n_participants":null,"pmid":"19033669","source_url":"https://pubmed.ncbi.nlm.nih.gov/19033669/","study_design":null,"title":"apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain","title_match":false,"year":2008},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-genotype-and-sex-risk-factors-for-alzheimer-disease-28846757","doi":"10.1001/jamaneurol.2017.2188","journal":"JAMA neurology","n_participants":null,"pmid":"28846757","source_url":"https://pubmed.ncbi.nlm.nih.gov/28846757/","study_design":"case-control study","title":"Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis","title_match":false,"year":2017},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/the-genetics-of-alzheimer-disease-23028126","doi":"10.1101/cshperspect.a006296","journal":"Cold Spring Harbor perspectives in medicine","n_participants":null,"pmid":"23028126","source_url":"https://pubmed.ncbi.nlm.nih.gov/23028126/","study_design":null,"title":"The genetics of Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/the-apoe-epsilon4-allele-and-the-risk-of-alzheimer-disease-among-9508150","doi":"10.1001/jama.279.10.751","journal":"JAMA","n_participants":1079,"pmid":"9508150","source_url":"https://pubmed.ncbi.nlm.nih.gov/9508150/","study_design":"longitudinal study","title":"The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics","title_match":true,"year":1998},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/apoe-and-alzheimer-disease-a-major-gene-with-semi-dominant-inheritance-21556001","doi":"10.1038/mp.2011.52","journal":"Molecular psychiatry","n_participants":null,"pmid":"21556001","source_url":"https://pubmed.ncbi.nlm.nih.gov/21556001/","study_design":null,"title":"APOE and Alzheimer disease: a major gene with semi-dominant inheritance","title_match":false,"year":2011},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/a-phase-2-multiple-ascending-dose-trial-of-bapineuzumab-in-mild-to-19923550","doi":"10.1212/wnl.0b013e3181c67808","journal":"Neurology","n_participants":234,"pmid":"19923550","source_url":"https://pubmed.ncbi.nlm.nih.gov/19923550/","study_design":"clinical trial","title":"A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease","title_match":false,"year":2009},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/improved-discrimination-of-ad-patients-using-beta-amyloid-1-42-and-10331678","doi":"10.1212/wnl.52.8.1555","journal":"Neurology","n_participants":84,"pmid":"10331678","source_url":"https://pubmed.ncbi.nlm.nih.gov/10331678/","study_design":null,"title":"Improved discrimination of AD patients using beta-amyloid(1-42) and tau levels in CSF","title_match":false,"year":1999},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-epsilon4-allele-elevated-midlife-total-cholesterol-12160362","doi":"10.7326/0003-4819-137-3-200208060-00006","journal":"Annals of internal medicine","n_participants":1449,"pmid":"12160362","source_url":"https://pubmed.ncbi.nlm.nih.gov/12160362/","study_design":null,"title":"Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease","title_match":true,"year":2002},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/clinical-genetic-and-neuropathologic-characteristics-of-posterior-15477533","doi":"10.1212/01.wnl.0000140289.18472.15","journal":"Neurology","n_participants":null,"pmid":"15477533","source_url":"https://pubmed.ncbi.nlm.nih.gov/15477533/","study_design":null,"title":"Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy","title_match":false,"year":2004},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/comparing-predictors-of-conversion-and-decline-in-mild-cognitive-20592257","doi":"10.1212/wnl.0b013e3181e8e8b8","journal":"Neurology","n_participants":85,"pmid":"20592257","source_url":"https://pubmed.ncbi.nlm.nih.gov/20592257/","study_design":"longitudinal study","title":"Comparing predictors of conversion and decline in mild cognitive impairment","title_match":false,"year":2010},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/duration-of-preclinical-prodromal-and-dementia-stages-of-alzheimer-s-31164314","doi":"10.1016/j.jalz.2019.04.001","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":3268,"pmid":"31164314","source_url":"https://pubmed.ncbi.nlm.nih.gov/31164314/","study_design":null,"title":"Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype","title_match":false,"year":2019},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-epsilon4-associated-with-chronic-traumatic-brain-9214529","doi":"10.1001/jama.1997.03550020068040","journal":"JAMA","n_participants":null,"pmid":"9214529","source_url":"https://pubmed.ncbi.nlm.nih.gov/9214529/","study_design":null,"title":"Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing","title_match":true,"year":1997},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/dietary-patterns-and-risk-of-dementia-the-three-city-cohort-study-17998483","doi":"10.1212/01.wnl.0000278116.37320.52","journal":"Neurology","n_participants":8085,"pmid":"17998483","source_url":"https://pubmed.ncbi.nlm.nih.gov/17998483/","study_design":"cohort study","title":"Dietary patterns and risk of dementia: the Three-City cohort study","title_match":false,"year":2007},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/alpha-2-macroglobulin-is-genetically-associated-with-alzheimer-disease-9697696","doi":"10.1038/1243","journal":"Nature genetics","n_participants":null,"pmid":"9697696","source_url":"https://pubmed.ncbi.nlm.nih.gov/9697696/","study_design":null,"title":"Alpha-2 macroglobulin is genetically associated with Alzheimer disease","title_match":false,"year":1998},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/dietary-intake-of-antioxidant-nutrients-and-the-risk-of-incident-12076219","doi":"10.1001/jama.287.24.3230","journal":"JAMA","n_participants":null,"pmid":"12076219","source_url":"https://pubmed.ncbi.nlm.nih.gov/12076219/","study_design":null,"title":"Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study","title_match":false,"year":2002},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/central-nervous-system-lipoproteins-apoe-and-regulation-of-27174096","doi":"10.1161/atvbaha.116.307023","journal":"Arteriosclerosis, thrombosis, and vascular biology","n_participants":null,"pmid":"27174096","source_url":"https://pubmed.ncbi.nlm.nih.gov/27174096/","study_design":null,"title":"Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism","title_match":false,"year":2016},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/the-probabilistic-model-of-alzheimer-disease-the-amyloid-hypothesis-34815562","doi":"10.1038/s41583-021-00533-w","journal":"Nature reviews. Neuroscience","n_participants":null,"pmid":"34815562","source_url":"https://pubmed.ncbi.nlm.nih.gov/34815562/","study_design":null,"title":"The probabilistic model of Alzheimer disease: the amyloid hypothesis revised","title_match":false,"year":2022},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-type-4-allele-and-cerebral-glucose-metabolism-in-7884953","doi":"10.1001/jama.1995.03520360056039","journal":"JAMA","n_participants":12,"pmid":"7884953","source_url":"https://pubmed.ncbi.nlm.nih.gov/7884953/","study_design":"longitudinal study","title":"Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease","title_match":false,"year":1995},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/biological-subtypes-of-alzheimer-disease-a-systematic-review-and-meta-32047067","doi":"10.1212/wnl.0000000000009058","journal":"Neurology","n_participants":null,"pmid":"32047067","source_url":"https://pubmed.ncbi.nlm.nih.gov/32047067/","study_design":"systematic review","title":"Biological subtypes of Alzheimer disease: A systematic review and meta-analysis","title_match":false,"year":2020},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/diabetes-alzheimer-disease-and-vascular-dementia-a-population-based-20739645","doi":"10.1212/wnl.0b013e3181f4d7f8","journal":"Neurology","n_participants":553,"pmid":"20739645","source_url":"https://pubmed.ncbi.nlm.nih.gov/20739645/","study_design":null,"title":"Diabetes, Alzheimer disease, and vascular dementia: a population-based neuropathologic study","title_match":false,"year":2010},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/evaluation-of-csf-tau-and-csf-abeta42-as-diagnostic-markers-for-11255440","doi":"10.1001/archneur.58.3.373","journal":"Archives of neurology","n_participants":105,"pmid":"11255440","source_url":"https://pubmed.ncbi.nlm.nih.gov/11255440/","study_design":null,"title":"Evaluation of CSF-tau and CSF-Abeta42 as diagnostic markers for Alzheimer disease in clinical practice","title_match":false,"year":2001},{"alzhub_score":78,"alzhub_url":"https://alzhub.org/study/variants-in-the-atp-binding-cassette-transporter-abca7-apolipoprotein-23571587","doi":"10.1001/jama.2013.2973","journal":"JAMA","n_participants":5896,"pmid":"23571587","source_url":"https://pubmed.ncbi.nlm.nih.gov/23571587/","study_design":"meta-analysis","title":"Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E \u03f54,and the risk of late-onset Alzheimer disease in African Americans","title_match":true,"year":2013},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/depressive-symptoms-and-risk-of-dementia-the-framingham-heart-study-20603483","doi":"10.1212/wnl.0b013e3181e62138","journal":"Neurology","n_participants":164,"pmid":"20603483","source_url":"https://pubmed.ncbi.nlm.nih.gov/20603483/","study_design":null,"title":"Depressive symptoms and risk of dementia: the Framingham Heart Study","title_match":false,"year":2010},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/amyloid-burden-in-healthy-aging-regional-distribution-and-cognitive-22302550","doi":"10.1212/wnl.0b013e318245d295","journal":"Neurology","n_participants":137,"pmid":"22302550","source_url":"https://pubmed.ncbi.nlm.nih.gov/22302550/","study_design":null,"title":"\u03b2-Amyloid burden in healthy aging: regional distribution and cognitive consequences","title_match":false,"year":2012},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/meta-analysis-confirms-cr1-clu-and-picalm-as-alzheimer-disease-risk-20697030","doi":"10.1001/archneurol.2010.201","journal":"Archives of neurology","n_participants":null,"pmid":"20697030","source_url":"https://pubmed.ncbi.nlm.nih.gov/20697030/","study_design":null,"title":"Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes","title_match":false,"year":2010},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-allele-as-a-predictor-of-cholinergic-deficits-and-8618881","doi":"10.1073/pnas.92.26.12260","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":40,"pmid":"8618881","source_url":"https://pubmed.ncbi.nlm.nih.gov/8618881/","study_design":null,"title":"Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease","title_match":true,"year":1995},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/two-types-of-sporadic-cerebral-amyloid-angiopathy-11895043","doi":"10.1093/jnen/61.3.282","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"11895043","source_url":"https://pubmed.ncbi.nlm.nih.gov/11895043/","study_design":null,"title":"Two types of sporadic cerebral amyloid angiopathy","title_match":false,"year":2002},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/head-injury-and-the-risk-of-ad-in-the-mirage-study-10746604","doi":"10.1212/wnl.54.6.1316","journal":"Neurology","n_participants":2233,"pmid":"10746604","source_url":"https://pubmed.ncbi.nlm.nih.gov/10746604/","study_design":null,"title":"Head injury and the risk of AD in the MIRAGE study","title_match":false,"year":2000},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/sex-differences-in-the-association-of-global-amyloid-and-regional-tau-30715078","doi":"10.1001/jamaneurol.2018.4693","journal":"JAMA neurology","n_participants":89,"pmid":"30715078","source_url":"https://pubmed.ncbi.nlm.nih.gov/30715078/","study_design":"cross-sectional","title":"Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults","title_match":false,"year":2019},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/assessment-of-racial-disparities-in-biomarkers-for-alzheimer-disease-30615028","doi":"10.1001/jamaneurol.2018.4249","journal":"JAMA neurology","n_participants":1255,"pmid":"30615028","source_url":"https://pubmed.ncbi.nlm.nih.gov/30615028/","study_design":"cross-sectional","title":"Assessment of Racial Disparities in Biomarkers for Alzheimer Disease","title_match":false,"year":2019},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/association-between-olfactory-dysfunction-and-amnestic-mild-cognitive-26569387","doi":"10.1001/jamaneurol.2015.2952","journal":"JAMA neurology","n_participants":1630,"pmid":"26569387","source_url":"https://pubmed.ncbi.nlm.nih.gov/26569387/","study_design":"longitudinal study","title":"Association Between Olfactory Dysfunction and Amnestic Mild Cognitive Impairment and Alzheimer Disease Dementia","title_match":false,"year":2016},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/apoe-4-increases-risk-for-dementia-in-pure-synucleinopathies-23407718","doi":"10.1001/jamaneurol.2013.600","journal":"JAMA neurology","n_participants":244,"pmid":"23407718","source_url":"https://pubmed.ncbi.nlm.nih.gov/23407718/","study_design":"case-control study","title":"APOE \u03b54 increases risk for dementia in pure synucleinopathies","title_match":true,"year":2013},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/insulin-resistance-is-associated-with-the-pathology-of-alzheimer-20739649","doi":"10.1212/wnl.0b013e3181eee25f","journal":"Neurology","n_participants":null,"pmid":"20739649","source_url":"https://pubmed.ncbi.nlm.nih.gov/20739649/","study_design":null,"title":"Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study","title_match":false,"year":2010},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/isoform-specific-interactions-of-apolipoprotein-e-with-microtubule-7972031","doi":"10.1073/pnas.91.23.11183","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"7972031","source_url":"https://pubmed.ncbi.nlm.nih.gov/7972031/","study_design":null,"title":"Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease","title_match":false,"year":1994},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/age-related-changes-in-the-default-mode-network-are-more-advanced-in-21975202","doi":"10.1212/wnl.0b013e318233b33d","journal":"Neurology","n_participants":28,"pmid":"21975202","source_url":"https://pubmed.ncbi.nlm.nih.gov/21975202/","study_design":null,"title":"Age-related changes in the default mode network are more advanced in Alzheimer disease","title_match":false,"year":2011},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/cognitive-aging-in-black-and-white-americans-cognition-cognitive-28863046","doi":"10.1097/ede.0000000000000747","journal":"Epidemiology (Cambridge, Mass.)","n_participants":7735,"pmid":"28863046","source_url":"https://pubmed.ncbi.nlm.nih.gov/28863046/","study_design":null,"title":"Cognitive Aging in Black and White Americans: Cognition, Cognitive Decline, and Incidence of Alzheimer Disease Dementia","title_match":false,"year":2018},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/sex-specific-association-of-apolipoprotein-e-with-cerebrospinal-fluid-29801024","doi":"10.1001/jamaneurol.2018.0821","journal":"JAMA neurology","n_participants":1798,"pmid":"29801024","source_url":"https://pubmed.ncbi.nlm.nih.gov/29801024/","study_design":"cohort study","title":"Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau","title_match":false,"year":2018},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/using-positron-emission-tomography-and-florbetapir-f18-to-image-21747008","doi":"10.1001/archneurol.2011.150","journal":"Archives of neurology","n_participants":46,"pmid":"21747008","source_url":"https://pubmed.ncbi.nlm.nih.gov/21747008/","study_design":null,"title":"Using positron emission tomography and florbetapir F18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to Alzheimer disease","title_match":false,"year":2011},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/safety-and-tolerability-of-the-secretase-inhibitor-avagacestat-in-a-22892585","doi":"10.1001/archneurol.2012.2194","journal":"Archives of neurology","n_participants":209,"pmid":"22892585","source_url":"https://pubmed.ncbi.nlm.nih.gov/22892585/","study_design":"clinical trial","title":"Safety and tolerability of the \u03b3-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/fmri-evidence-of-compensatory-mechanisms-in-older-adults-at-genetic-15699382","doi":"10.1212/01.wnl.0000150885.00929.7e","journal":"Neurology","n_participants":null,"pmid":"15699382","source_url":"https://pubmed.ncbi.nlm.nih.gov/15699382/","study_design":null,"title":"fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease","title_match":false,"year":2005},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/incidence-of-alzheimer-disease-in-a-biracial-urban-community-relation-12580702","doi":"10.1001/archneur.60.2.185","journal":"Archives of neurology","n_participants":6158,"pmid":"12580702","source_url":"https://pubmed.ncbi.nlm.nih.gov/12580702/","study_design":null,"title":"Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status","title_match":false,"year":2003},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/cerebral-amyloid-angiopathy-and-its-relationship-to-alzheimer-s-18369648","doi":"10.1007/s00401-008-0366-2","journal":"Acta neuropathologica","n_participants":null,"pmid":"18369648","source_url":"https://pubmed.ncbi.nlm.nih.gov/18369648/","study_design":null,"title":"Cerebral amyloid angiopathy and its relationship to Alzheimer's disease","title_match":false,"year":2008},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/risk-estimates-of-dementia-by-apolipoprotein-e-genotypes-from-a-9678314","doi":"10.1001/archneur.55.7.964","journal":"Archives of neurology","n_participants":134,"pmid":"9678314","source_url":"https://pubmed.ncbi.nlm.nih.gov/9678314/","study_design":"cohort study","title":"Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study","title_match":false,"year":1998},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/insulin-metabolism-and-the-risk-of-alzheimer-disease-the-rotterdam-21115952","doi":"10.1212/wnl.0b013e3181ffe4f6","journal":"Neurology","n_participants":3139,"pmid":"21115952","source_url":"https://pubmed.ncbi.nlm.nih.gov/21115952/","study_design":"cohort study","title":"Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study","title_match":false,"year":2010},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/amyloid-and-apoe-4-interact-to-influence-short-term-decline-in-24748674","doi":"10.1212/wnl.0000000000000431","journal":"Neurology","n_participants":null,"pmid":"24748674","source_url":"https://pubmed.ncbi.nlm.nih.gov/24748674/","study_design":"cohort study","title":"Amyloid and APOE \u03b54 interact to influence short-term decline in preclinical Alzheimer disease","title_match":true,"year":2014},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/risk-of-dementia-among-white-and-african-american-relatives-of-11790212","doi":"10.1001/jama.287.3.329","journal":"JAMA","n_participants":17,"pmid":"11790212","source_url":"https://pubmed.ncbi.nlm.nih.gov/11790212/","study_design":null,"title":"Risk of dementia among white and African American relatives of patients with Alzheimer disease","title_match":false,"year":2002},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/low-density-lipoprotein-receptor-related-protein-mediates-7568158","doi":"10.1073/pnas.92.21.9480","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"7568158","source_url":"https://pubmed.ncbi.nlm.nih.gov/7568158/","study_design":null,"title":"Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line","title_match":false,"year":1995},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/plasma-24s-hydroxycholesterol-cerebrosterol-is-increased-in-alzheimer-10681402","doi":"10.1016/s0022-2275(20)32052-6","journal":"Journal of lipid research","n_participants":12,"pmid":"10681402","source_url":"https://pubmed.ncbi.nlm.nih.gov/10681402/","study_design":null,"title":"Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients","title_match":false,"year":2000},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/sex-amyloid-and-apoe-4-and-risk-of-cognitive-decline-in-preclinical-29803541","doi":"10.1016/j.jalz.2018.04.010","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":755,"pmid":"29803541","source_url":"https://pubmed.ncbi.nlm.nih.gov/29803541/","study_design":null,"title":"Sex, amyloid, and APOE \u03b54 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts","title_match":true,"year":2018},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/suspected-non-alzheimer-disease-pathophysiology-concept-and-26782335","doi":"10.1038/nrneurol.2015.251","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"26782335","source_url":"https://pubmed.ncbi.nlm.nih.gov/26782335/","study_design":null,"title":"Suspected non-Alzheimer disease pathophysiology--concept and controversy","title_match":false,"year":2016},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/benefits-of-fatty-fish-on-dementia-risk-are-stronger-for-those-16275829","doi":"10.1212/01.wnl.0000183148.34197.2e","journal":"Neurology","n_participants":null,"pmid":"16275829","source_url":"https://pubmed.ncbi.nlm.nih.gov/16275829/","study_design":null,"title":"Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4","title_match":true,"year":2005},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/mci-conversion-to-dementia-and-the-apoe-genotype-a-prediction-study-15623696","doi":"10.1212/01.wnl.0000147469.18313.3b","journal":"Neurology","n_participants":37,"pmid":"15623696","source_url":"https://pubmed.ncbi.nlm.nih.gov/15623696/","study_design":null,"title":"MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET","title_match":false,"year":2004},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/antioxidant-vitamin-intake-and-risk-of-alzheimer-disease-12580704","doi":"10.1001/archneur.60.2.203","journal":"Archives of neurology","n_participants":null,"pmid":"12580704","source_url":"https://pubmed.ncbi.nlm.nih.gov/12580704/","study_design":null,"title":"Antioxidant vitamin intake and risk of Alzheimer disease","title_match":false,"year":2003},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-dependent-accumulation-of-alzheimer-disease-related-19557866","doi":"10.1002/ana.21696","journal":"Annals of neurology","n_participants":603,"pmid":"19557866","source_url":"https://pubmed.ncbi.nlm.nih.gov/19557866/","study_design":null,"title":"Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age","title_match":false,"year":2009},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-is-a-kinetic-but-not-a-thermodynamic-inhibitor-of-7846048","doi":"10.1073/pnas.92.3.763","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"7846048","source_url":"https://pubmed.ncbi.nlm.nih.gov/7846048/","study_design":null,"title":"Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease","title_match":false,"year":1995},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apoe4-specific-changes-in-a-accumulation-in-a-new-transgenic-mouse-23060451","doi":"10.1074/jbc.m112.407957","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"23060451","source_url":"https://pubmed.ncbi.nlm.nih.gov/23060451/","study_design":null,"title":"APOE4-specific changes in A\u03b2 accumulation in a new transgenic mouse model of Alzheimer disease","title_match":true,"year":2012},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/cerebrovascular-effects-of-apolipoprotein-e-implications-for-23400708","doi":"10.1001/jamaneurol.2013.2152","journal":"JAMA neurology","n_participants":null,"pmid":"23400708","source_url":"https://pubmed.ncbi.nlm.nih.gov/23400708/","study_design":null,"title":"Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease","title_match":false,"year":2013},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/serum-cholesterol-changes-after-midlife-and-late-life-cognition-17339582","doi":"10.1212/01.wnl.0000256368.57375.b7","journal":"Neurology","n_participants":1449,"pmid":"17339582","source_url":"https://pubmed.ncbi.nlm.nih.gov/17339582/","study_design":"longitudinal study","title":"Serum cholesterol changes after midlife and late-life cognition: twenty-one-year follow-up study","title_match":false,"year":2007},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/analysis-of-european-mitochondrial-haplogroups-with-alzheimer-disease-15234467","doi":"10.1016/j.neulet.2004.04.051","journal":"Neuroscience letters","n_participants":null,"pmid":"15234467","source_url":"https://pubmed.ncbi.nlm.nih.gov/15234467/","study_design":null,"title":"Analysis of European mitochondrial haplogroups with Alzheimer disease risk","title_match":false,"year":2004},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/brain-differences-in-infants-at-differential-genetic-risk-for-late-24276092","doi":"10.1001/jamaneurol.2013.4544","journal":"JAMA neurology","n_participants":null,"pmid":"24276092","source_url":"https://pubmed.ncbi.nlm.nih.gov/24276092/","study_design":"cross-sectional","title":"Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study","title_match":false,"year":2014},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/enhanced-risk-for-alzheimer-disease-in-persons-with-type-2-diabetes-18195144","doi":"10.1001/archneurol.2007.29","journal":"Archives of neurology","n_participants":null,"pmid":"18195144","source_url":"https://pubmed.ncbi.nlm.nih.gov/18195144/","study_design":null,"title":"Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study","title_match":true,"year":2008},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/course-of-cerebral-amyloid-angiopathy-related-inflammation-17452586","doi":"10.1212/01.wnl.0000260066.98681.2e","journal":"Neurology","n_participants":null,"pmid":"17452586","source_url":"https://pubmed.ncbi.nlm.nih.gov/17452586/","study_design":null,"title":"Course of cerebral amyloid angiopathy-related inflammation","title_match":false,"year":2007},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/association-of-chronic-low-grade-inflammation-with-risk-of-alzheimer-30646251","doi":"10.1001/jamanetworkopen.2018.3597","journal":"JAMA network open","n_participants":null,"pmid":"30646251","source_url":"https://pubmed.ncbi.nlm.nih.gov/30646251/","study_design":"cohort study","title":"Association of Chronic Low-grade Inflammation With Risk of Alzheimer Disease in ApoE4 Carriers","title_match":true,"year":2018},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/modification-of-the-relationship-of-the-apolipoprotein-e-4-allele-to-24145819","doi":"10.1001/jamaneurol.2013.4215","journal":"JAMA neurology","n_participants":698,"pmid":"24145819","source_url":"https://pubmed.ncbi.nlm.nih.gov/24145819/","study_design":"cohort study","title":"Modification of the relationship of the apolipoprotein E \u03b54 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep","title_match":true,"year":2013},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-regulates-the-integrity-of-tight-junctions-in-an-21471207","doi":"10.1074/jbc.m111.225532","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"21471207","source_url":"https://pubmed.ncbi.nlm.nih.gov/21471207/","study_design":null,"title":"Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model","title_match":false,"year":2011},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/ginkgo-biloba-for-preventing-cognitive-decline-in-older-adults-a-20040554","doi":"10.1001/jama.2009.1913","journal":"JAMA","n_participants":1545,"pmid":"20040554","source_url":"https://pubmed.ncbi.nlm.nih.gov/20040554/","study_design":null,"title":"Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial","title_match":false,"year":2009},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-epsilon4-and-the-risk-of-dementia-with-stroke-a-9052712","doi":"10.1001/jama.277.10.818","journal":"JAMA","n_participants":187,"pmid":"9052712","source_url":"https://pubmed.ncbi.nlm.nih.gov/9052712/","study_design":"case-control study","title":"Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation","title_match":true,"year":1997},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/dementia-with-lewy-bodies-and-parkinson-s-disease-dementia-current-29222591","doi":"10.1007/s00702-017-1821-9","journal":"Journal of neural transmission (Vienna, Austria : 1996)","n_participants":null,"pmid":"29222591","source_url":"https://pubmed.ncbi.nlm.nih.gov/29222591/","study_design":null,"title":"Dementia with Lewy bodies and Parkinson's disease-dementia: current concepts and controversies","title_match":false,"year":2018},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-polymorphism-and-alzheimer-disease-the-indo-us-cross-10867779","doi":"10.1001/archneur.57.6.824","journal":"Archives of neurology","n_participants":4450,"pmid":"10867779","source_url":"https://pubmed.ncbi.nlm.nih.gov/10867779/","study_design":"cohort study","title":"Apolipoprotein E polymorphism and Alzheimer disease: The Indo-US Cross-National Dementia Study","title_match":false,"year":2000},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/female-advantage-in-verbal-memory-evidence-of-sex-specific-cognitive-27708128","doi":"10.1212/wnl.0000000000003288","journal":"Neurology","n_participants":672,"pmid":"27708128","source_url":"https://pubmed.ncbi.nlm.nih.gov/27708128/","study_design":"cross-sectional","title":"Female advantage in verbal memory: Evidence of sex-specific cognitive reserve","title_match":false,"year":2016},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/cancer-linked-to-alzheimer-disease-but-not-vascular-dementia-20032288","doi":"10.1212/wnl.0b013e3181c91873","journal":"Neurology","n_participants":3020,"pmid":"20032288","source_url":"https://pubmed.ncbi.nlm.nih.gov/20032288/","study_design":"cohort study","title":"Cancer linked to Alzheimer disease but not vascular dementia","title_match":false,"year":2010},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/implementing-diagnostic-criteria-and-estimating-frequency-of-mild-16286549","doi":"10.1001/archneur.62.11.1739","journal":"Archives of neurology","n_participants":null,"pmid":"16286549","source_url":"https://pubmed.ncbi.nlm.nih.gov/16286549/","study_design":"cohort study","title":"Implementing diagnostic criteria and estimating frequency of mild cognitive impairment in an urban community","title_match":false,"year":2005},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/sex-apolipoprotein-e-epsilon-4-status-and-hippocampal-volume-in-mild-15956166","doi":"10.1001/archneur.62.6.953","journal":"Archives of neurology","n_participants":193,"pmid":"15956166","source_url":"https://pubmed.ncbi.nlm.nih.gov/15956166/","study_design":null,"title":"Sex, apolipoprotein E epsilon 4 status, and hippocampal volume in mild cognitive impairment","title_match":false,"year":2005},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/plasma-multianalyte-profiling-in-mild-cognitive-impairment-and-22855860","doi":"10.1212/wnl.0b013e318266fa70","journal":"Neurology","n_participants":566,"pmid":"22855860","source_url":"https://pubmed.ncbi.nlm.nih.gov/22855860/","study_design":null,"title":"Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/association-of-higher-levels-of-high-density-lipoprotein-cholesterol-21149810","doi":"10.1001/archneurol.2010.297","journal":"Archives of neurology","n_participants":null,"pmid":"21149810","source_url":"https://pubmed.ncbi.nlm.nih.gov/21149810/","study_design":"cohort study","title":"Association of higher levels of high-density lipoprotein cholesterol in elderly individuals and lower risk of late-onset Alzheimer disease","title_match":false,"year":2010},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/clinical-syndromes-associated-with-posterior-atrophy-early-age-at-19901249","doi":"10.1212/wnl.0b013e3181c0d427","journal":"Neurology","n_participants":30,"pmid":"19901249","source_url":"https://pubmed.ncbi.nlm.nih.gov/19901249/","study_design":null,"title":"Clinical syndromes associated with posterior atrophy: early age at onset AD spectrum","title_match":false,"year":2009},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/lt-i-gt-apoe-lt-i-gt-4-is-associated-with-severity-of-lewy-body-30143564","doi":"10.1212/wnl.0000000000006212","journal":"Neurology","n_participants":null,"pmid":"30143564","source_url":"https://pubmed.ncbi.nlm.nih.gov/30143564/","study_design":"case-control study","title":"APOE \u03b54 is associated with severity of Lewy body pathology independent of Alzheimer pathology","title_match":true,"year":2018},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/the-biphasic-relationship-between-regional-brain-senile-plaque-and-15246987","doi":"10.1196/annals.1297.005","journal":"Annals of the New York Academy of Sciences","n_participants":null,"pmid":"15246987","source_url":"https://pubmed.ncbi.nlm.nih.gov/15246987/","study_design":null,"title":"The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: modification by age, sex, and APOE polymorphism","title_match":false,"year":2004},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/transethnic-genome-wide-scan-identifies-novel-alzheimer-s-disease-loci-28183528","doi":"10.1016/j.jalz.2016.12.012","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"28183528","source_url":"https://pubmed.ncbi.nlm.nih.gov/28183528/","study_design":null,"title":"Transethnic genome-wide scan identifies novel Alzheimer's disease loci","title_match":false,"year":2017},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/apoe-epsilon4-genotype-and-longitudinal-changes-in-cerebral-blood-20065135","doi":"10.1001/archneurol.2009.913","journal":"Archives of neurology","n_participants":null,"pmid":"20065135","source_url":"https://pubmed.ncbi.nlm.nih.gov/20065135/","study_design":"longitudinal study","title":"APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging","title_match":true,"year":2010},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/apoe-isoform-dependent-sars-cov-2-neurotropism-and-cellular-response-33450186","doi":"10.1016/j.stem.2020.12.018","journal":"Cell stem cell","n_participants":null,"pmid":"33450186","source_url":"https://pubmed.ncbi.nlm.nih.gov/33450186/","study_design":null,"title":"ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response","title_match":false,"year":2021},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/episodic-memory-changes-are-associated-with-the-apoe-epsilon-4-allele-8848194","doi":"10.1212/wnl.45.12.2203","journal":"Neurology","n_participants":17,"pmid":"8848194","source_url":"https://pubmed.ncbi.nlm.nih.gov/8848194/","study_design":null,"title":"Episodic memory changes are associated with the APOE-epsilon 4 allele in nondemented older adults","title_match":true,"year":1995},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/prevalence-and-clinical-phenotype-of-quadruple-misfolded-proteins-in-32568358","doi":"10.1001/jamaneurol.2020.1741","journal":"JAMA neurology","n_participants":375,"pmid":"32568358","source_url":"https://pubmed.ncbi.nlm.nih.gov/32568358/","study_design":"cohort study","title":"Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults","title_match":false,"year":2020},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/ancestral-origin-of-apoe-4-alzheimer-disease-risk-in-puerto-rican-and-30517106","doi":"10.1371/journal.pgen.1007791","journal":"PLoS genetics","n_participants":1766,"pmid":"30517106","source_url":"https://pubmed.ncbi.nlm.nih.gov/30517106/","study_design":null,"title":"Ancestral origin of ApoE \u03b54 Alzheimer disease risk in Puerto Rican and African American populations","title_match":true,"year":2018},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/longitudinal-changes-in-cognition-and-behavior-in-asymptomatic-15184602","doi":"10.1212/01.wnl.0000129533.26544.bf","journal":"Neurology","n_participants":212,"pmid":"15184602","source_url":"https://pubmed.ncbi.nlm.nih.gov/15184602/","study_design":"longitudinal study","title":"Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOE e4 allele","title_match":true,"year":2004},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-risk-factor-for-alzheimer-disease-8128961","doi":null,"journal":"American journal of human genetics","n_participants":77,"pmid":"8128961","source_url":"https://pubmed.ncbi.nlm.nih.gov/8128961/","study_design":null,"title":"Apolipoprotein E: risk factor for Alzheimer disease","title_match":false,"year":1994},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/age-dependent-effects-of-apoe-reduction-using-antisense-29216448","doi":"10.1016/j.neuron.2017.11.014","journal":"Neuron","n_participants":null,"pmid":"29216448","source_url":"https://pubmed.ncbi.nlm.nih.gov/29216448/","study_design":null,"title":"Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of \u03b2-amyloidosis","title_match":false,"year":2017},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/insulin-like-growth-factor-1-and-risk-of-alzheimer-dementia-and-brain-24706014","doi":"10.1212/wnl.0000000000000382","journal":"Neurology","n_participants":789,"pmid":"24706014","source_url":"https://pubmed.ncbi.nlm.nih.gov/24706014/","study_design":null,"title":"Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy","title_match":false,"year":2014},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/rapidly-progressive-alzheimer-s-disease-features-distinct-structures-25688081","doi":"10.1093/brain/awv006","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"25688081","source_url":"https://pubmed.ncbi.nlm.nih.gov/25688081/","study_design":null,"title":"Rapidly progressive Alzheimer's disease features distinct structures of amyloid-\u03b2","title_match":false,"year":2015},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/apoe-mapt-and-snca-genes-and-cognitive-performance-in-parkinson-25178429","doi":"10.1001/jamaneurol.2014.1455","journal":"JAMA neurology","n_participants":1079,"pmid":"25178429","source_url":"https://pubmed.ncbi.nlm.nih.gov/25178429/","study_design":null,"title":"APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease","title_match":false,"year":2014},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/cognitive-and-neuroimaging-features-and-brain-amyloidosis-in-29500152","doi":"10.1016/s1474-4422(18)30029-2","journal":"The Lancet. Neurology","n_participants":318,"pmid":"29500152","source_url":"https://pubmed.ncbi.nlm.nih.gov/29500152/","study_design":null,"title":"Cognitive and neuroimaging features and brain \u03b2-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): a longitudinal observational study","title_match":false,"year":2018},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/apoe-epsilon-4-allele-predicts-faster-cognitive-decline-in-mild-18401023","doi":"10.1212/01.wnl.0000304038.37421.cc","journal":"Neurology","n_participants":null,"pmid":"18401023","source_url":"https://pubmed.ncbi.nlm.nih.gov/18401023/","study_design":"cohort study","title":"APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease","title_match":true,"year":2008},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/cell-type-specific-roles-of-apoe4-in-alzheimer-disease-38191720","doi":"10.1038/s41583-023-00776-9","journal":"Nature reviews. Neuroscience","n_participants":null,"pmid":"38191720","source_url":"https://pubmed.ncbi.nlm.nih.gov/38191720/","study_design":null,"title":"Cell type-specific roles of APOE4 in Alzheimer disease","title_match":true,"year":2024},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/better-verbal-memory-in-women-than-men-in-mci-despite-similar-levels-26984945","doi":"10.1212/wnl.0000000000002570","journal":"Neurology","n_participants":379,"pmid":"26984945","source_url":"https://pubmed.ncbi.nlm.nih.gov/26984945/","study_design":"cross-sectional","title":"Better verbal memory in women than men in MCI despite similar levels of hippocampal atrophy","title_match":false,"year":2016},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/hiv-infected-subjects-with-the-e4-allele-for-apoe-have-excess-9771753","doi":"10.1038/2677","journal":"Nature medicine","n_participants":null,"pmid":"9771753","source_url":"https://pubmed.ncbi.nlm.nih.gov/9771753/","study_design":null,"title":"HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy","title_match":true,"year":1998},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/csf-biomarkers-for-alzheimer-disease-correlate-with-cortical-brain-22517093","doi":"10.1212/wnl.0b013e3182563bd0","journal":"Neurology","n_participants":182,"pmid":"22517093","source_url":"https://pubmed.ncbi.nlm.nih.gov/22517093/","study_design":null,"title":"CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings","title_match":false,"year":2012},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/impact-of-apoe-genotype-on-neuropathologic-and-neurochemical-markers-15184600","doi":"10.1212/01.wnl.0000128091.92139.0f","journal":"Neurology","n_participants":296,"pmid":"15184600","source_url":"https://pubmed.ncbi.nlm.nih.gov/15184600/","study_design":null,"title":"Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease","title_match":false,"year":2004},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/tracking-early-decline-in-cognitive-function-in-older-individuals-at-25706191","doi":"10.1001/jamaneurol.2014.3375","journal":"JAMA neurology","n_participants":468,"pmid":"25706191","source_url":"https://pubmed.ncbi.nlm.nih.gov/25706191/","study_design":"longitudinal study","title":"Tracking early decline in cognitive function in older individuals at risk for Alzheimer disease dementia: the Alzheimer's Disease Cooperative Study Cognitive Function Instrument","title_match":false,"year":2015},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/apoe-alleles-predict-the-rate-of-cognitive-decline-in-alzheimer-16380608","doi":"10.1212/01.wnl.0000188871.74093.12","journal":"Neurology","n_participants":218,"pmid":"16380608","source_url":"https://pubmed.ncbi.nlm.nih.gov/16380608/","study_design":null,"title":"APOE alleles predict the rate of cognitive decline in Alzheimer disease: a nonlinear model","title_match":false,"year":2005},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/statin-therapy-and-risk-of-dementia-in-the-elderly-a-community-based-15534246","doi":"10.1212/01.wnl.0000142963.90204.58","journal":"Neurology","n_participants":312,"pmid":"15534246","source_url":"https://pubmed.ncbi.nlm.nih.gov/15534246/","study_design":"cohort study","title":"Statin therapy and risk of dementia in the elderly: a community-based prospective cohort study","title_match":false,"year":2004},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/association-of-amyloid-reduction-after-donanemab-treatment-with-tau-36094645","doi":"10.1001/jamaneurol.2022.2793","journal":"JAMA neurology","n_participants":272,"pmid":"36094645","source_url":"https://pubmed.ncbi.nlm.nih.gov/36094645/","study_design":"clinical trial","title":"Association of Amyloid Reduction After Donanemab Treatment With Tau Pathology and Clinical Outcomes: The TRAILBLAZER-ALZ Randomized Clinical Trial","title_match":false,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-domain-interaction-mediates-detrimental-effects-on-21118811","doi":"10.1074/jbc.m110.151084","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"21118811","source_url":"https://pubmed.ncbi.nlm.nih.gov/21118811/","study_design":null,"title":"Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease","title_match":true,"year":2011},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/prediction-of-individual-clinical-outcome-in-mci-by-means-of-genetic-16204712","doi":null,"journal":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","n_participants":22,"pmid":"16204712","source_url":"https://pubmed.ncbi.nlm.nih.gov/16204712/","study_design":"longitudinal study","title":"Prediction of individual clinical outcome in MCI by means of genetic assessment and (18)F-FDG PET","title_match":false,"year":2005},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/association-between-apolipoprotein-e-epsilon4-and-sleep-disordered-11401610","doi":"10.1001/jama.285.22.2888","journal":"JAMA","n_participants":null,"pmid":"11401610","source_url":"https://pubmed.ncbi.nlm.nih.gov/11401610/","study_design":"cohort study","title":"Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults","title_match":true,"year":2001},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/elevated-serum-pesticide-levels-and-risk-for-alzheimer-disease-24473795","doi":"10.1001/jamaneurol.2013.6030","journal":"JAMA neurology","n_participants":20,"pmid":"24473795","source_url":"https://pubmed.ncbi.nlm.nih.gov/24473795/","study_design":"case-control study","title":"Elevated serum pesticide levels and risk for Alzheimer disease","title_match":false,"year":2014},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/exploring-the-etiology-of-alzheimer-disease-using-molecular-genetics-9052714","doi":"10.1001/jama.1997.03540340059034","journal":"JAMA","n_participants":null,"pmid":"9052714","source_url":"https://pubmed.ncbi.nlm.nih.gov/9052714/","study_design":null,"title":"Exploring the etiology of Alzheimer disease using molecular genetics","title_match":false,"year":1997},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/impaired-insulin-secretion-increases-the-risk-of-alzheimer-disease-18401020","doi":"10.1212/01.wnl.0000310646.32212.3a","journal":"Neurology","n_participants":2322,"pmid":"18401020","source_url":"https://pubmed.ncbi.nlm.nih.gov/18401020/","study_design":"longitudinal study","title":"Impaired insulin secretion increases the risk of Alzheimer disease","title_match":false,"year":2008},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/differential-regulation-of-amyloid-endocytic-trafficking-and-23132858","doi":"10.1074/jbc.m112.420224","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"23132858","source_url":"https://pubmed.ncbi.nlm.nih.gov/23132858/","study_design":null,"title":"Differential regulation of amyloid-\u03b2 endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms","title_match":false,"year":2012},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/association-of-apolipoprotein-e-genotype-with-brain-levels-of-8774959","doi":"10.1016/0169-328x(95)00097-c","journal":"Brain research. Molecular brain research","n_participants":null,"pmid":"8774959","source_url":"https://pubmed.ncbi.nlm.nih.gov/8774959/","study_design":null,"title":"Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease","title_match":false,"year":1995},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/prevalence-of-amyloid-pathology-in-distinct-variants-of-primary-30255971","doi":"10.1002/ana.25333","journal":"Annals of neurology","n_participants":443,"pmid":"30255971","source_url":"https://pubmed.ncbi.nlm.nih.gov/30255971/","study_design":"meta-analysis","title":"Prevalence of amyloid-\u03b2 pathology in distinct variants of primary progressive aphasia","title_match":false,"year":2018},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/arterial-stiffness-and-dementia-pathology-atherosclerosis-risk-in-29549223","doi":"10.1212/wnl.0000000000005259","journal":"Neurology","n_participants":null,"pmid":"29549223","source_url":"https://pubmed.ncbi.nlm.nih.gov/29549223/","study_design":"cross-sectional","title":"Arterial stiffness and dementia pathology: Atherosclerosis Risk in Communities (ARIC)-PET Study","title_match":false,"year":2018},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/sleep-and-longitudinal-cognitive-performance-in-preclinical-and-early-34668959","doi":"10.1093/brain/awab272","journal":"Brain : a journal of neurology","n_participants":100,"pmid":"34668959","source_url":"https://pubmed.ncbi.nlm.nih.gov/34668959/","study_design":"cross-sectional","title":"Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/apoe2-is-associated-with-milder-clinical-and-pathological-alzheimer-25623662","doi":"10.1002/ana.24369","journal":"Annals of neurology","n_participants":null,"pmid":"25623662","source_url":"https://pubmed.ncbi.nlm.nih.gov/25623662/","study_design":null,"title":"APOE\u03b52 is associated with milder clinical and pathological Alzheimer disease","title_match":false,"year":2015},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/biomarkers-for-insulin-resistance-and-inflammation-and-the-risk-for-22213409","doi":"10.1001/archneurol.2011.670","journal":"Archives of neurology","n_participants":159,"pmid":"22213409","source_url":"https://pubmed.ncbi.nlm.nih.gov/22213409/","study_design":"cohort study","title":"Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study","title_match":false,"year":2012},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/targeting-of-nonlipidated-aggregated-apoe-with-antibodies-inhibits-29600961","doi":"10.1172/jci96429","journal":"The Journal of clinical investigation","n_participants":null,"pmid":"29600961","source_url":"https://pubmed.ncbi.nlm.nih.gov/29600961/","study_design":null,"title":"Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation","title_match":false,"year":2018},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/clinical-predictors-of-progression-to-alzheimer-disease-in-amnestic-17287448","doi":"10.1212/01.wnl.0000258542.58725.4c","journal":"Neurology","n_participants":539,"pmid":"17287448","source_url":"https://pubmed.ncbi.nlm.nih.gov/17287448/","study_design":null,"title":"Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment","title_match":false,"year":2007},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/effect-of-apolipoprotein-e-on-biomarkers-of-amyloid-load-and-neuronal-20373342","doi":"10.1002/ana.21953","journal":"Annals of neurology","n_participants":399,"pmid":"20373342","source_url":"https://pubmed.ncbi.nlm.nih.gov/20373342/","study_design":null,"title":"Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease","title_match":false,"year":2010},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/amyloid-related-imaging-abnormalities-and-amyloid-targeting-35099507","doi":"10.1001/jamaneurol.2021.5205","journal":"JAMA neurology","n_participants":null,"pmid":"35099507","source_url":"https://pubmed.ncbi.nlm.nih.gov/35099507/","study_design":"systematic review","title":"Amyloid-Related Imaging Abnormalities and \u03b2-Amyloid-Targeting Antibodies: A Systematic Review","title_match":false,"year":2022},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/the-apolipoprotein-e-epsilon-4-allele-and-decline-in-different-12117364","doi":"10.1001/archneur.59.7.1154","journal":"Archives of neurology","n_participants":624,"pmid":"12117364","source_url":"https://pubmed.ncbi.nlm.nih.gov/12117364/","study_design":"cohort study","title":"The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period","title_match":false,"year":2002},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/longitudinal-brain-imaging-in-preclinical-alzheimer-disease-impact-of-29672664","doi":"10.1093/brain/awy103","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"29672664","source_url":"https://pubmed.ncbi.nlm.nih.gov/29672664/","study_design":"longitudinal study","title":"Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE \u03b54 genotype","title_match":true,"year":2018},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/identification-of-novel-loci-for-alzheimer-disease-and-replication-of-21059989","doi":"10.1001/archneurol.2010.292","journal":"Archives of neurology","n_participants":null,"pmid":"21059989","source_url":"https://pubmed.ncbi.nlm.nih.gov/21059989/","study_design":"case-control study","title":"Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals","title_match":false,"year":2011},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/assessment-of-demographic-genetic-and-imaging-variables-associated-32091549","doi":"10.1001/jamaneurol.2019.5154","journal":"JAMA neurology","n_participants":260,"pmid":"32091549","source_url":"https://pubmed.ncbi.nlm.nih.gov/32091549/","study_design":"cross-sectional","title":"Assessment of Demographic, Genetic, and Imaging Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Patients With Alzheimer Disease","title_match":false,"year":2020},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/indicators-of-amyloid-burden-in-a-population-based-study-of-22972644","doi":"10.1212/wnl.0b013e31826e2696","journal":"Neurology","n_participants":100,"pmid":"22972644","source_url":"https://pubmed.ncbi.nlm.nih.gov/22972644/","study_design":null,"title":"Indicators of amyloid burden in a population-based study of cognitively normal elderly","title_match":false,"year":2012},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/modulation-of-alzheimer-like-synaptic-and-cholinergic-deficits-in-12486146","doi":"10.1523/jneurosci.22-24-10539.2002","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"12486146","source_url":"https://pubmed.ncbi.nlm.nih.gov/12486146/","study_design":null,"title":"Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation","title_match":false,"year":2002},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/the-role-of-apoe-and-trem2-in-alzheimer-s-disease-current-30587772","doi":"10.3390/ijms20010081","journal":"International journal of molecular sciences","n_participants":null,"pmid":"30587772","source_url":"https://pubmed.ncbi.nlm.nih.gov/30587772/","study_design":null,"title":"The Role of APOE and TREM2 in Alzheimer's Disease-Current Understanding and Perspectives","title_match":false,"year":2018},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-oxidative-stress-in-brain-with-relevance-to-32036033","doi":"10.1016/j.nbd.2020.104795","journal":"Neurobiology of disease","n_participants":null,"pmid":"32036033","source_url":"https://pubmed.ncbi.nlm.nih.gov/32036033/","study_design":null,"title":"Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/multifaceted-roles-of-apoe-in-alzheimer-disease-38906999","doi":"10.1038/s41582-024-00988-2","journal":"Nature reviews. Neurology","n_participants":null,"pmid":"38906999","source_url":"https://pubmed.ncbi.nlm.nih.gov/38906999/","study_design":null,"title":"Multifaceted roles of APOE in Alzheimer disease","title_match":false,"year":2024},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/a-summary-risk-score-for-the-prediction-of-alzheimer-disease-in-20625090","doi":"10.1001/archneurol.2010.136","journal":"Archives of neurology","n_participants":null,"pmid":"20625090","source_url":"https://pubmed.ncbi.nlm.nih.gov/20625090/","study_design":"longitudinal study","title":"A summary risk score for the prediction of Alzheimer disease in elderly persons","title_match":false,"year":2010},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/amyloid-precursor-protein-metabolism-and-inflammation-markers-in-26180139","doi":"10.1212/wnl.0000000000001859","journal":"Neurology","n_participants":null,"pmid":"26180139","source_url":"https://pubmed.ncbi.nlm.nih.gov/26180139/","study_design":"cross-sectional","title":"Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease","title_match":false,"year":2015},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/posterior-cingulate-glucose-metabolism-hippocampal-glucose-metabolism-23599929","doi":"10.1001/2013.jamaneurol.286","journal":"JAMA neurology","n_participants":31,"pmid":"23599929","source_url":"https://pubmed.ncbi.nlm.nih.gov/23599929/","study_design":"cross-sectional","title":"Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease","title_match":false,"year":2013},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/evidence-for-an-interaction-between-apolipoprotein-e-genotype-gender-10609670","doi":"10.1097/00002093-199910000-00007","journal":"Alzheimer disease and associated disorders","n_participants":195,"pmid":"10609670","source_url":"https://pubmed.ncbi.nlm.nih.gov/10609670/","study_design":"longitudinal study","title":"Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease","title_match":false,"year":1999},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/associations-between-cerebral-small-vessel-disease-and-alzheimer-24818585","doi":"10.1001/jamaneurol.2014.754","journal":"JAMA neurology","n_participants":914,"pmid":"24818585","source_url":"https://pubmed.ncbi.nlm.nih.gov/24818585/","study_design":"cross-sectional","title":"Associations between cerebral small-vessel disease and Alzheimer disease pathology as measured by cerebrospinal fluid biomarkers","title_match":false,"year":2014},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/nsaid-use-and-dementia-risk-in-the-cardiovascular-health-study-role-18003940","doi":"10.1212/01.wnl.0000284596.95156.48","journal":"Neurology","n_participants":3229,"pmid":"18003940","source_url":"https://pubmed.ncbi.nlm.nih.gov/18003940/","study_design":"cohort study","title":"NSAID use and dementia risk in the Cardiovascular Health Study: role of APOE and NSAID type","title_match":false,"year":2008},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/insulin-resistance-and-hippocampal-volume-in-women-at-risk-for-20031276","doi":"10.1016/j.neurobiolaging.2009.12.005","journal":"Neurobiology of aging","n_participants":null,"pmid":"20031276","source_url":"https://pubmed.ncbi.nlm.nih.gov/20031276/","study_design":"longitudinal study","title":"Insulin resistance and hippocampal volume in women at risk for Alzheimer's disease","title_match":false,"year":2011},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/association-of-dementia-with-mortality-among-adults-with-down-30452522","doi":"10.1001/jamaneurol.2018.3616","journal":"JAMA neurology","n_participants":300,"pmid":"30452522","source_url":"https://pubmed.ncbi.nlm.nih.gov/30452522/","study_design":"longitudinal study","title":"Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years","title_match":false,"year":2019},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/quantitative-analysis-of-senile-plaques-in-alzheimer-disease-7724603","doi":"10.1073/pnas.92.8.3586","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"7724603","source_url":"https://pubmed.ncbi.nlm.nih.gov/7724603/","study_design":null,"title":"Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome)","title_match":false,"year":1995},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/contribution-to-alzheimer-s-disease-risk-of-rare-variants-in-trem2-28789839","doi":"10.1016/j.neurobiolaging.2017.07.001","journal":"Neurobiology of aging","n_participants":null,"pmid":"28789839","source_url":"https://pubmed.ncbi.nlm.nih.gov/28789839/","study_design":null,"title":"Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls","title_match":false,"year":2017},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/plasma-levels-of-apolipoprotein-e-and-risk-of-dementia-in-the-general-25469919","doi":"10.1002/ana.24326","journal":"Annals of neurology","n_participants":75708,"pmid":"25469919","source_url":"https://pubmed.ncbi.nlm.nih.gov/25469919/","study_design":null,"title":"Plasma levels of apolipoprotein E and risk of dementia in the general population","title_match":false,"year":2015},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/incidence-of-cerebral-microbleeds-in-preclinical-alzheimer-disease-24623839","doi":"10.1212/wnl.0000000000000285","journal":"Neurology","n_participants":null,"pmid":"24623839","source_url":"https://pubmed.ncbi.nlm.nih.gov/24623839/","study_design":"longitudinal study","title":"Incidence of cerebral microbleeds in preclinical Alzheimer disease","title_match":false,"year":2014},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/systemic-inflammation-infection-apoe-alleles-and-alzheimer-disease-a-17430245","doi":"10.2174/156720507780362254","journal":"Current Alzheimer research","n_participants":null,"pmid":"17430245","source_url":"https://pubmed.ncbi.nlm.nih.gov/17430245/","study_design":null,"title":"Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper","title_match":false,"year":2007},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/conversion-to-dementia-from-mild-cognitive-disorder-the-cache-county-16864813","doi":"10.1212/01.wnl.0000224748.48011.84","journal":"Neurology","n_participants":120,"pmid":"16864813","source_url":"https://pubmed.ncbi.nlm.nih.gov/16864813/","study_design":null,"title":"Conversion to dementia from mild cognitive disorder: the Cache County Study","title_match":false,"year":2006},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/impact-of-apoe-in-mild-cognitive-impairment-15557508","doi":"10.1212/01.wnl.0000144279.21502.b7","journal":"Neurology","n_participants":494,"pmid":"15557508","source_url":"https://pubmed.ncbi.nlm.nih.gov/15557508/","study_design":null,"title":"Impact of APOE in mild cognitive impairment","title_match":false,"year":2004},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/increased-risk-of-late-posttraumatic-seizures-associated-with-12810485","doi":"10.1001/archneur.60.6.818","journal":"Archives of neurology","n_participants":106,"pmid":"12810485","source_url":"https://pubmed.ncbi.nlm.nih.gov/12810485/","study_design":null,"title":"Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 allele","title_match":true,"year":2003},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apoe-epsilon2-is-associated-with-intact-cognition-but-increased-19255410","doi":"10.1212/01.wnl.0000343853.00346.a4","journal":"Neurology","n_participants":null,"pmid":"19255410","source_url":"https://pubmed.ncbi.nlm.nih.gov/19255410/","study_design":null,"title":"APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old","title_match":false,"year":2009},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/apoe-related-risk-of-mild-cognitive-impairment-and-dementia-for-28323826","doi":"10.1371/journal.pmed.1002254","journal":"PLoS medicine","n_participants":5073,"pmid":"28323826","source_url":"https://pubmed.ncbi.nlm.nih.gov/28323826/","study_design":null,"title":"APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts","title_match":false,"year":2017},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/genetic-association-between-intronic-polymorphism-in-presenilin-1-8596269","doi":"10.1016/s0140-6736(96)91140-x","journal":"Lancet (London, England)","n_participants":29,"pmid":"8596269","source_url":"https://pubmed.ncbi.nlm.nih.gov/8596269/","study_design":null,"title":"Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group","title_match":false,"year":1996},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/neuropsychiatric-symptoms-as-risk-factors-for-progression-from-cind-23567370","doi":"10.1016/j.jagp.2013.01.049","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":230,"pmid":"23567370","source_url":"https://pubmed.ncbi.nlm.nih.gov/23567370/","study_design":null,"title":"Neuropsychiatric symptoms as risk factors for progression from CIND to dementia: the Cache County Study","title_match":false,"year":2013},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/altered-brain-white-matter-integrity-in-healthy-carriers-of-the-apoe-16606914","doi":"10.1212/01.wnl.0000204180.25361.48","journal":"Neurology","n_participants":null,"pmid":"16606914","source_url":"https://pubmed.ncbi.nlm.nih.gov/16606914/","study_design":null,"title":"Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD?","title_match":true,"year":2006},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/apoe-2-and-apoe-4-correlate-with-increased-amyloid-accumulation-in-23771217","doi":"10.1097/nen.0b013e31829a25b9","journal":"Journal of neuropathology and experimental neurology","n_participants":22,"pmid":"23771217","source_url":"https://pubmed.ncbi.nlm.nih.gov/23771217/","study_design":null,"title":"APOE-\u03b52 and APOE-\u03b54 correlate with increased amyloid accumulation in cerebral vasculature","title_match":true,"year":2013},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/levels-of-soluble-apolipoprotein-e-amyloid-a-complex-are-reduced-and-23293020","doi":"10.1074/jbc.m112.442103","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"23293020","source_url":"https://pubmed.ncbi.nlm.nih.gov/23293020/","study_design":null,"title":"Levels of soluble apolipoprotein E/amyloid-\u03b2 (A\u03b2) complex are reduced and oligomeric A\u03b2 increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples","title_match":true,"year":2013},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/association-of-mediterranean-dash-intervention-for-neurodegenerative-36889921","doi":"10.1212/wnl.0000000000207176","journal":"Neurology","n_participants":581,"pmid":"36889921","source_url":"https://pubmed.ncbi.nlm.nih.gov/36889921/","study_design":null,"title":"Association of Mediterranean-DASH Intervention for Neurodegenerative Delay and Mediterranean Diets With Alzheimer Disease Pathology","title_match":false,"year":2023},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/spontaneous-aria-like-events-in-cerebral-amyloid-angiopathy-related-34531298","doi":"10.1212/wnl.0000000000012778","journal":"Neurology","n_participants":113,"pmid":"34531298","source_url":"https://pubmed.ncbi.nlm.nih.gov/34531298/","study_design":"longitudinal study","title":"Spontaneous ARIA-like Events in Cerebral Amyloid Angiopathy-Related Inflammation: A Multicenter Prospective Longitudinal Cohort Study","title_match":false,"year":2021},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/a-randomized-controlled-study-on-effects-of-ibuprofen-on-cognitive-19448381","doi":"10.1007/bf03325217","journal":"Aging clinical and experimental research","n_participants":27,"pmid":"19448381","source_url":"https://pubmed.ncbi.nlm.nih.gov/19448381/","study_design":null,"title":"A randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease","title_match":false,"year":2009},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/decreased-expression-and-activity-of-neprilysin-in-alzheimer-disease-17021406","doi":"10.1097/01.jnen.0000240463.87886.9a","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"17021406","source_url":"https://pubmed.ncbi.nlm.nih.gov/17021406/","study_design":null,"title":"Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy","title_match":false,"year":2006},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/late-onset-alzheimer-disease-30707185","doi":"10.1212/con.0000000000000700","journal":"Continuum (Minneapolis, Minn.)","n_participants":null,"pmid":"30707185","source_url":"https://pubmed.ncbi.nlm.nih.gov/30707185/","study_design":null,"title":"Late-onset Alzheimer Disease","title_match":false,"year":2019},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/lack-of-hepatic-apoe-does-not-influence-early-a-deposition-31623648","doi":"10.1186/s13024-019-0337-1","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"31623648","source_url":"https://pubmed.ncbi.nlm.nih.gov/31623648/","study_design":null,"title":"Lack of hepatic apoE does not influence early A\u03b2 deposition: observations from a new APOE knock-in model","title_match":false,"year":2019},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/association-of-docosahexaenoic-acid-supplementation-with-alzheimer-28114437","doi":"10.1001/jamaneurol.2016.4899","journal":"JAMA neurology","n_participants":null,"pmid":"28114437","source_url":"https://pubmed.ncbi.nlm.nih.gov/28114437/","study_design":null,"title":"Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E \u03b54 Carriers: A Review","title_match":true,"year":2017},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/amyloid-11c-pib-pet-imaging-results-from-2-randomized-bapineuzumab-26208959","doi":"10.1212/wnl.0000000000001877","journal":"Neurology","n_participants":115,"pmid":"26208959","source_url":"https://pubmed.ncbi.nlm.nih.gov/26208959/","study_design":"clinical trial","title":"Amyloid-\u03b2 11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials","title_match":false,"year":2015},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-epsilon4-count-affects-age-at-onset-of-alzheimer-15123497","doi":"10.1001/archpsyc.61.5.518","journal":"Archives of general psychiatry","n_participants":3308,"pmid":"15123497","source_url":"https://pubmed.ncbi.nlm.nih.gov/15123497/","study_design":"longitudinal study","title":"Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County Study","title_match":true,"year":2004},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/why-are-stroke-patients-prone-to-develop-dementia-9050953","doi":"10.1007/s004150050064","journal":"Journal of neurology","n_participants":null,"pmid":"9050953","source_url":"https://pubmed.ncbi.nlm.nih.gov/9050953/","study_design":null,"title":"Why are stroke patients prone to develop dementia?","title_match":false,"year":1997},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-with-suspected-nonamyloid-pathology-snap-25568301","doi":"10.1212/wnl.0000000000001209","journal":"Neurology","n_participants":201,"pmid":"25568301","source_url":"https://pubmed.ncbi.nlm.nih.gov/25568301/","study_design":null,"title":"Mild cognitive impairment with suspected nonamyloid pathology (SNAP): Prediction of progression","title_match":false,"year":2015},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/plasma-apolipoprotein-e-and-alzheimer-disease-risk-the-aibl-study-of-21422459","doi":"10.1212/wnl.0b013e318211c352","journal":"Neurology","n_participants":1079,"pmid":"21422459","source_url":"https://pubmed.ncbi.nlm.nih.gov/21422459/","study_design":"cross-sectional","title":"Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging","title_match":false,"year":2011},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/neurofibrillary-tangle-predominant-dementia-comparison-with-classical-17089134","doi":"10.1007/s00401-006-0156-7","journal":"Acta neuropathologica","n_participants":null,"pmid":"17089134","source_url":"https://pubmed.ncbi.nlm.nih.gov/17089134/","study_design":null,"title":"Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease","title_match":false,"year":2007},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/chronic-divalproex-sodium-use-and-brain-atrophy-in-alzheimer-disease-21917762","doi":"10.1212/wnl.0b013e318230a16c","journal":"Neurology","n_participants":313,"pmid":"21917762","source_url":"https://pubmed.ncbi.nlm.nih.gov/21917762/","study_design":null,"title":"Chronic divalproex sodium use and brain atrophy in Alzheimer disease","title_match":false,"year":2011},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/relative-risk-of-alzheimer-disease-and-age-at-onset-distributions-8644717","doi":null,"journal":"American journal of human genetics","n_participants":null,"pmid":"8644717","source_url":"https://pubmed.ncbi.nlm.nih.gov/8644717/","study_design":null,"title":"Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City","title_match":false,"year":1996},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/cardiovascular-risk-factors-and-incident-alzheimer-disease-a-18703981","doi":"10.1097/wad.0b013e318187541c","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"18703981","source_url":"https://pubmed.ncbi.nlm.nih.gov/18703981/","study_design":"systematic review","title":"Cardiovascular risk factors and incident Alzheimer disease: a systematic review of the literature","title_match":false,"year":2009},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/serum-cholesterol-and-risk-of-alzheimer-disease-a-community-based-16217057","doi":"10.1212/01.wnl.0000178989.87072.11","journal":"Neurology","n_participants":null,"pmid":"16217057","source_url":"https://pubmed.ncbi.nlm.nih.gov/16217057/","study_design":"cohort study","title":"Serum cholesterol and risk of Alzheimer disease: a community-based cohort study","title_match":false,"year":2005},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/neuroimaging-in-alzheimer-disease-an-evidence-based-review-13677801","doi":"10.1016/s1052-5149(03)00025-x","journal":"Neuroimaging clinics of North America","n_participants":null,"pmid":"13677801","source_url":"https://pubmed.ncbi.nlm.nih.gov/13677801/","study_design":"longitudinal study","title":"Neuroimaging in Alzheimer disease: an evidence-based review","title_match":false,"year":2003},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/amyloid-and-tau-biomarkers-and-clinical-phenotype-in-dementia-with-32989106","doi":"10.1212/wnl.0000000000010943","journal":"Neurology","n_participants":417,"pmid":"32989106","source_url":"https://pubmed.ncbi.nlm.nih.gov/32989106/","study_design":null,"title":"\u03b2-Amyloid and tau biomarkers and clinical phenotype in dementia with Lewy bodies","title_match":false,"year":2020},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/the-influence-of-alzheimer-disease-family-history-and-apolipoprotein-16738250","doi":"10.1523/jneurosci.0959-06.2006","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"16738250","source_url":"https://pubmed.ncbi.nlm.nih.gov/16738250/","study_design":null,"title":"The influence of Alzheimer disease family history and apolipoprotein E epsilon4 on mesial temporal lobe activation","title_match":true,"year":2006},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/clinical-features-and-apoe-genotype-of-pathologically-proven-early-21576687","doi":"10.1212/wnl.0b013e31821a44dd","journal":"Neurology","n_participants":37,"pmid":"21576687","source_url":"https://pubmed.ncbi.nlm.nih.gov/21576687/","study_design":null,"title":"Clinical features and APOE genotype of pathologically proven early-onset Alzheimer disease","title_match":false,"year":2011},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-impairs-the-response-of-neurodegenerative-retinal-35977543","doi":"10.1016/j.immuni.2022.07.014","journal":"Immunity","n_participants":null,"pmid":"35977543","source_url":"https://pubmed.ncbi.nlm.nih.gov/35977543/","study_design":null,"title":"Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma","title_match":true,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/the-risk-of-incident-mild-cognitive-impairment-and-progression-to-28413413","doi":"10.1159/000452486","journal":"Dementia and geriatric cognitive disorders extra","n_participants":null,"pmid":"28413413","source_url":"https://pubmed.ncbi.nlm.nih.gov/28413413/","study_design":null,"title":"The Risk of Incident Mild Cognitive Impairment and Progression to Dementia Considering Mild Cognitive Impairment Subtypes","title_match":false,"year":2017},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/apoe-epsilon-2-allele-associated-with-higher-prevalence-of-sporadic-15210882","doi":"10.1212/01.wnl.0000130159.28215.6a","journal":"Neurology","n_participants":null,"pmid":"15210882","source_url":"https://pubmed.ncbi.nlm.nih.gov/15210882/","study_design":"systematic review","title":"APOE-[epsilon]2 allele associated with higher prevalence of sporadic Parkinson disease","title_match":false,"year":2004},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/neuronal-apolipoprotein-e4-increases-cell-death-and-phosphorylated-30840313","doi":"10.1002/ana.25455","journal":"Annals of neurology","n_participants":null,"pmid":"30840313","source_url":"https://pubmed.ncbi.nlm.nih.gov/30840313/","study_design":null,"title":"Neuronal apolipoprotein E4 increases cell death and phosphorylated tau release in alzheimer disease","title_match":true,"year":2019},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/odor-identification-as-a-biomarker-of-preclinical-ad-in-older-adults-28659431","doi":"10.1212/wnl.0000000000004159","journal":"Neurology","n_participants":101,"pmid":"28659431","source_url":"https://pubmed.ncbi.nlm.nih.gov/28659431/","study_design":"cross-sectional","title":"Odor identification as a biomarker of preclinical AD in older adults at risk","title_match":false,"year":2017},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/cognitive-domain-decline-in-healthy-apolipoprotein-e-epsilon4-17846270","doi":"10.1001/archneur.64.9.1306","journal":"Archives of neurology","n_participants":214,"pmid":"17846270","source_url":"https://pubmed.ncbi.nlm.nih.gov/17846270/","study_design":null,"title":"Cognitive domain decline in healthy apolipoprotein E epsilon4 homozygotes before the diagnosis of mild cognitive impairment","title_match":true,"year":2007},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/apoe-by-sex-interactions-on-brain-structure-and-metabolism-in-healthy-26397226","doi":"10.18632/oncotarget.5185","journal":"Oncotarget","n_participants":274,"pmid":"26397226","source_url":"https://pubmed.ncbi.nlm.nih.gov/26397226/","study_design":"cross-sectional","title":"APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls","title_match":false,"year":2015},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/n-3-fatty-acid-erythrocyte-membrane-content-apoe-varepsilon4-and-18258638","doi":"10.1093/ajcn/87.2.449","journal":"The American journal of clinical nutrition","n_participants":null,"pmid":"18258638","source_url":"https://pubmed.ncbi.nlm.nih.gov/18258638/","study_design":null,"title":"n-3 Fatty acid erythrocyte membrane content, APOE varepsilon4, and cognitive variation: an observational follow-up study in late adulthood","title_match":false,"year":2008},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/the-low-density-lipoprotein-receptor-regulates-the-level-of-central-15888448","doi":"10.1074/jbc.m502143200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"15888448","source_url":"https://pubmed.ncbi.nlm.nih.gov/15888448/","study_design":null,"title":"The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice","title_match":false,"year":2005},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/the-association-between-a-polygenic-alzheimer-score-and-cortical-22169231","doi":"10.1093/cercor/bhr348","journal":"Cerebral cortex (New York, N.Y. : 1991)","n_participants":104,"pmid":"22169231","source_url":"https://pubmed.ncbi.nlm.nih.gov/22169231/","study_design":null,"title":"The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects","title_match":false,"year":2012},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/evaluating-the-patterns-of-aging-related-tau-astrogliopathy-unravels-28340083","doi":"10.1093/jnen/nlx007","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"28340083","source_url":"https://pubmed.ncbi.nlm.nih.gov/28340083/","study_design":null,"title":"Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases","title_match":false,"year":2017},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/microglial-activation-in-alzheimer-disease-association-with-apoe-9669695","doi":"10.1111/j.1750-3639.1998.tb00166.x","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"9669695","source_url":"https://pubmed.ncbi.nlm.nih.gov/9669695/","study_design":null,"title":"Microglial activation in Alzheimer disease: Association with APOE genotype","title_match":false,"year":1998},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/prediction-of-alzheimer-disease-in-subjects-with-amnestic-and-23446677","doi":"10.1212/wnl.0b013e318288690c","journal":"Neurology","n_participants":231,"pmid":"23446677","source_url":"https://pubmed.ncbi.nlm.nih.gov/23446677/","study_design":null,"title":"Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI","title_match":false,"year":2013},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/apoe-vascular-pathology-and-the-ad-brain-16043796","doi":"10.1212/01.wnl.0000168863.49053.4d","journal":"Neurology","n_participants":null,"pmid":"16043796","source_url":"https://pubmed.ncbi.nlm.nih.gov/16043796/","study_design":null,"title":"APOE, vascular pathology, and the AD brain","title_match":false,"year":2005},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/temporal-dynamics-of-amyloid-accumulation-in-aging-and-alzheimer-33408147","doi":"10.1212/wnl.0000000000011524","journal":"Neurology","n_participants":475,"pmid":"33408147","source_url":"https://pubmed.ncbi.nlm.nih.gov/33408147/","study_design":null,"title":"Temporal Dynamics of \u03b2-Amyloid Accumulation in Aging and Alzheimer Disease","title_match":false,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/serial-mri-and-csf-biomarkers-in-normal-aging-mci-and-ad-20625167","doi":"10.1212/wnl.0b013e3181e7ca82","journal":"Neurology","n_participants":312,"pmid":"20625167","source_url":"https://pubmed.ncbi.nlm.nih.gov/20625167/","study_design":null,"title":"Serial MRI and CSF biomarkers in normal aging, MCI, and AD","title_match":false,"year":2010},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/single-nucleus-rna-sequencing-of-autosomal-dominant-alzheimer-disease-37085492","doi":"10.1038/s41467-023-37437-5","journal":"Nature communications","n_participants":null,"pmid":"37085492","source_url":"https://pubmed.ncbi.nlm.nih.gov/37085492/","study_design":null,"title":"Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers","title_match":false,"year":2023},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/melatonin-reverses-the-profibrillogenic-activity-of-apolipoprotein-e4-11732920","doi":"10.1021/bi0114269","journal":"Biochemistry","n_participants":null,"pmid":"11732920","source_url":"https://pubmed.ncbi.nlm.nih.gov/11732920/","study_design":null,"title":"Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide","title_match":true,"year":2001},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/association-of-apoe-4-genotype-and-lifestyle-with-cognitive-function-34061824","doi":"10.1371/journal.pmed.1003597","journal":"PLoS medicine","n_participants":null,"pmid":"34061824","source_url":"https://pubmed.ncbi.nlm.nih.gov/34061824/","study_design":"cohort study","title":"Association of APOE \u03b54 genotype and lifestyle with cognitive function among Chinese adults aged 80 years and older: A cross-sectional study","title_match":true,"year":2021},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/association-of-early-onset-alzheimer-disease-with-elevated-low-31135820","doi":"10.1001/jamaneurol.2019.0648","journal":"JAMA neurology","n_participants":null,"pmid":"31135820","source_url":"https://pubmed.ncbi.nlm.nih.gov/31135820/","study_design":null,"title":"Association of Early-Onset Alzheimer Disease With Elevated Low-Density Lipoprotein Cholesterol Levels and Rare Genetic Coding Variants of APOB","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/plasma-levels-of-apolipoprotein-e-apoe-genotype-and-risk-of-dementia-28340945","doi":"10.1016/j.atherosclerosis.2016.10.037","journal":"Atherosclerosis","n_participants":null,"pmid":"28340945","source_url":"https://pubmed.ncbi.nlm.nih.gov/28340945/","study_design":null,"title":"Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review","title_match":false,"year":2016},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-inhibits-autophagy-gene-products-through-direct-28945989","doi":"10.1016/j.jalz.2017.07.754","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"28945989","source_url":"https://pubmed.ncbi.nlm.nih.gov/28945989/","study_design":null,"title":"Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs","title_match":true,"year":2018},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/lower-cognitive-performance-in-normal-older-adult-male-twins-carrying-7986172","doi":"10.1001/archneur.1994.00540240033012","journal":"Archives of neurology","n_participants":null,"pmid":"7986172","source_url":"https://pubmed.ncbi.nlm.nih.gov/7986172/","study_design":null,"title":"Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E epsilon 4 allele","title_match":false,"year":1994},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/apoe2-e3-and-e4-differentially-modulate-cellular-homeostasis-34919811","doi":"10.1016/j.stemcr.2021.11.007","journal":"Stem cell reports","n_participants":null,"pmid":"34919811","source_url":"https://pubmed.ncbi.nlm.nih.gov/34919811/","study_design":null,"title":"APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes","title_match":false,"year":2022},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/measurement-of-alpha-and-beta-secretase-cleaved-amyloid-precursor-12957490","doi":"10.1016/s0014-4886(03)00027-x","journal":"Experimental neurology","n_participants":19,"pmid":"12957490","source_url":"https://pubmed.ncbi.nlm.nih.gov/12957490/","study_design":null,"title":"Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients","title_match":false,"year":2003},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/genetic-association-of-a-cystatin-c-gene-polymorphism-with-late-onset-11074789","doi":"10.1001/archneur.57.11.1579","journal":"Archives of neurology","n_participants":260,"pmid":"11074789","source_url":"https://pubmed.ncbi.nlm.nih.gov/11074789/","study_design":"case-control study","title":"Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease","title_match":false,"year":2000},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/distribution-of-reducible-4-hydroxynonenal-adduct-immunoreactivity-in-9596412","doi":"10.1097/00005072-199805000-00005","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"9596412","source_url":"https://pubmed.ncbi.nlm.nih.gov/9596412/","study_design":null,"title":"Distribution of reducible 4-hydroxynonenal adduct immunoreactivity in Alzheimer disease is associated with APOE genotype","title_match":false,"year":1998},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/hypothetical-preclinical-alzheimer-disease-groups-and-longitudinal-27064267","doi":"10.1001/jamaneurol.2016.0194","journal":"JAMA neurology","n_participants":null,"pmid":"27064267","source_url":"https://pubmed.ncbi.nlm.nih.gov/27064267/","study_design":"cohort study","title":"Hypothetical Preclinical Alzheimer Disease Groups and Longitudinal Cognitive Change","title_match":false,"year":2016},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/differential-effect-of-apoe-genotype-on-amyloid-load-and-glucose-23255822","doi":"10.1212/wnl.0b013e31827f0889","journal":"Neurology","n_participants":null,"pmid":"23255822","source_url":"https://pubmed.ncbi.nlm.nih.gov/23255822/","study_design":null,"title":"Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia","title_match":false,"year":2013},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/senile-dementia-with-tangles-tangle-predominant-form-of-senile-9546293","doi":"10.1111/j.1750-3639.1998.tb00160.x","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"9546293","source_url":"https://pubmed.ncbi.nlm.nih.gov/9546293/","study_design":null,"title":"Senile dementia with tangles (tangle predominant form of senile dementia)","title_match":false,"year":1998},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/vascular-risk-and-amyloid-are-synergistically-associated-with-30565287","doi":"10.1002/ana.25399","journal":"Annals of neurology","n_participants":null,"pmid":"30565287","source_url":"https://pubmed.ncbi.nlm.nih.gov/30565287/","study_design":null,"title":"Vascular Risk and \u03b2-Amyloid Are Synergistically Associated with Cortical Tau","title_match":false,"year":2019},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/associations-of-the-top-20-alzheimer-disease-risk-variants-with-brain-29340569","doi":"10.1001/jamaneurol.2017.4198","journal":"JAMA neurology","n_participants":977,"pmid":"29340569","source_url":"https://pubmed.ncbi.nlm.nih.gov/29340569/","study_design":null,"title":"Associations of the Top 20 Alzheimer Disease Risk Variants With Brain Amyloidosis","title_match":false,"year":2018},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-genotype-and-age-related-myelin-breakdown-in-healthy-16389198","doi":"10.1001/archpsyc.63.1.63","journal":"Archives of general psychiatry","n_participants":104,"pmid":"16389198","source_url":"https://pubmed.ncbi.nlm.nih.gov/16389198/","study_design":"cross-sectional","title":"Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementia","title_match":false,"year":2006},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-alzheimer-disease-an-update-on-genetic-and-11005255","doi":"10.1093/jnen/59.9.751","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"11005255","source_url":"https://pubmed.ncbi.nlm.nih.gov/11005255/","study_design":null,"title":"Apolipoprotein E and Alzheimer disease: an update on genetic and functional analyses","title_match":false,"year":2000},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/association-of-klotho-vs-heterozygosity-with-risk-of-alzheimer-32282020","doi":"10.1001/jamaneurol.2020.0414","journal":"JAMA neurology","n_participants":20,"pmid":"32282020","source_url":"https://pubmed.ncbi.nlm.nih.gov/32282020/","study_design":"case-control study","title":"Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4","title_match":true,"year":2020},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-dementia-in-parkinson-disease-a-meta-analysis-16476806","doi":"10.1001/archneur.63.2.189","journal":"Archives of neurology","n_participants":null,"pmid":"16476806","source_url":"https://pubmed.ncbi.nlm.nih.gov/16476806/","study_design":"case-control study","title":"Apolipoprotein E and dementia in Parkinson disease: a meta-analysis","title_match":false,"year":2006},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/association-of-loneliness-with-10-year-dementia-risk-and-early-35131906","doi":"10.1212/wnl.0000000000200039","journal":"Neurology","n_participants":2308,"pmid":"35131906","source_url":"https://pubmed.ncbi.nlm.nih.gov/35131906/","study_design":"cohort study","title":"Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline","title_match":false,"year":2022},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/meat-consumption-and-risk-of-incident-dementia-cohort-study-of-493-33748832","doi":"10.1093/ajcn/nqab028","journal":"The American journal of clinical nutrition","n_participants":493888,"pmid":"33748832","source_url":"https://pubmed.ncbi.nlm.nih.gov/33748832/","study_design":null,"title":"Meat consumption and risk of incident dementia: cohort study of 493,888 UK Biobank participants","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe-isoform-affects-ltp-in-human-targeted-replacement-mice-15570172","doi":"10.1097/00001756-200412030-00020","journal":"Neuroreport","n_participants":null,"pmid":"15570172","source_url":"https://pubmed.ncbi.nlm.nih.gov/15570172/","study_design":null,"title":"ApoE isoform affects LTP in human targeted replacement mice","title_match":false,"year":2004},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/cognitive-frailty-predementia-syndrome-and-vascular-risk-factors-16023766","doi":"10.1016/j.neurobiolaging.2005.05.008","journal":"Neurobiology of aging","n_participants":null,"pmid":"16023766","source_url":"https://pubmed.ncbi.nlm.nih.gov/16023766/","study_design":null,"title":"Cognitive frailty: Predementia syndrome and vascular risk factors","title_match":false,"year":2006},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/cerebral-glucose-metabolism-in-patients-with-ad-and-different-apoe-15642911","doi":"10.1212/01.wnl.0000148478.39691.d3","journal":"Neurology","n_participants":null,"pmid":"15642911","source_url":"https://pubmed.ncbi.nlm.nih.gov/15642911/","study_design":null,"title":"Cerebral glucose metabolism in patients with AD and different APOE genotypes","title_match":false,"year":2005},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/apoe-genotype-family-history-of-dementia-and-alzheimer-disease-risk-a-15596614","doi":"10.1001/archneur.61.12.1930","journal":"Archives of neurology","n_participants":907,"pmid":"15596614","source_url":"https://pubmed.ncbi.nlm.nih.gov/15596614/","study_design":"cohort study","title":"APOE genotype, family history of dementia, and Alzheimer disease risk: a 6-year follow-up study","title_match":false,"year":2004},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/evidence-for-an-alzheimer-disease-susceptibility-locus-on-chromosome-9718052","doi":"10.1001/jama.280.7.614","journal":"JAMA","n_participants":173,"pmid":"9718052","source_url":"https://pubmed.ncbi.nlm.nih.gov/9718052/","study_design":"cohort study","title":"Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity","title_match":false,"year":1998},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/frequency-of-the-apolipoprotein-e-epsilon-2-allele-is-diminished-in-7970208","doi":"10.1016/0304-3940(94)91074-x","journal":"Neuroscience letters","n_participants":null,"pmid":"7970208","source_url":"https://pubmed.ncbi.nlm.nih.gov/7970208/","study_design":null,"title":"Frequency of the apolipoprotein E epsilon 2 allele is diminished in sporadic Alzheimer disease","title_match":false,"year":1994},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/apoe2-eases-cognitive-decline-during-aging-clinical-and-preclinical-26933942","doi":"10.1002/ana.24628","journal":"Annals of neurology","n_participants":null,"pmid":"26933942","source_url":"https://pubmed.ncbi.nlm.nih.gov/26933942/","study_design":null,"title":"APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations","title_match":false,"year":2016},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/apoe-4-and-the-risk-for-alzheimer-disease-and-cognitive-decline-in-24565289","doi":"10.1017/s1041610214000167","journal":"International psychogeriatrics","n_participants":null,"pmid":"24565289","source_url":"https://pubmed.ncbi.nlm.nih.gov/24565289/","study_design":"longitudinal study","title":"APOE \u03b54 and the risk for Alzheimer disease and cognitive decline in African Americans and Yoruba","title_match":true,"year":2014},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/serum-triglycerides-in-alzheimer-disease-relation-to-neuroimaging-and-32358220","doi":"10.1212/wnl.0000000000009436","journal":"Neurology","n_participants":689,"pmid":"32358220","source_url":"https://pubmed.ncbi.nlm.nih.gov/32358220/","study_design":"longitudinal study","title":"Serum triglycerides in Alzheimer disease: Relation to neuroimaging and CSF biomarkers","title_match":false,"year":2020},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/omega-3-fatty-acids-and-risk-of-dementia-the-canadian-study-of-health-19474137","doi":"10.3945/ajcn.2008.26987","journal":"The American journal of clinical nutrition","n_participants":null,"pmid":"19474137","source_url":"https://pubmed.ncbi.nlm.nih.gov/19474137/","study_design":"cohort study","title":"Omega-3 fatty acids and risk of dementia: the Canadian Study of Health and Aging","title_match":false,"year":2009},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/cholesterol-apoe-genotype-and-alzheimer-disease-an-epidemiologic-16434658","doi":"10.1212/01.wnl.0000194507.39504.17","journal":"Neurology","n_participants":1075,"pmid":"16434658","source_url":"https://pubmed.ncbi.nlm.nih.gov/16434658/","study_design":"longitudinal study","title":"Cholesterol, APOE genotype, and Alzheimer disease: an epidemiologic study of Nigerian Yoruba","title_match":false,"year":2006},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-brain-injury-biomarker-vlp-1-is-increased-in-the-cerebrospinal-18703769","doi":"10.1373/clinchem.2008.104497","journal":"Clinical chemistry","n_participants":null,"pmid":"18703769","source_url":"https://pubmed.ncbi.nlm.nih.gov/18703769/","study_design":null,"title":"The brain injury biomarker VLP-1 is increased in the cerebrospinal fluid of Alzheimer disease patients","title_match":false,"year":2008},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-low-density-lipoprotein-receptor-related-protein-17012232","doi":"10.1074/jbc.m604436200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"17012232","source_url":"https://pubmed.ncbi.nlm.nih.gov/17012232/","study_design":null,"title":"Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice","title_match":false,"year":2006},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/apoe-epsilon4-allele-is-associated-with-reduced-cerebrospinal-fluid-15184629","doi":"10.1212/01.wnl.0000128088.08695.05","journal":"Neurology","n_participants":563,"pmid":"15184629","source_url":"https://pubmed.ncbi.nlm.nih.gov/15184629/","study_design":null,"title":"APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42","title_match":true,"year":2004},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/coronary-artery-disease-is-associated-with-alzheimer-disease-16682673","doi":"10.1212/01.wnl.0000210447.19748.0b","journal":"Neurology","n_participants":42,"pmid":"16682673","source_url":"https://pubmed.ncbi.nlm.nih.gov/16682673/","study_design":null,"title":"Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers","title_match":true,"year":2006},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/increased-midlife-triglycerides-predict-brain-amyloid-and-tau-29196581","doi":"10.1212/wnl.0000000000004749","journal":"Neurology","n_participants":134,"pmid":"29196581","source_url":"https://pubmed.ncbi.nlm.nih.gov/29196581/","study_design":"cohort study","title":"Increased midlife triglycerides predict brain \u03b2-amyloid and tau pathology 20 years later","title_match":false,"year":2018},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/screening-for-predementia-ad-time-dependent-operating-characteristics-23468542","doi":"10.1212/wnl.0b013e31828ab2c9","journal":"Neurology","n_participants":86,"pmid":"23468542","source_url":"https://pubmed.ncbi.nlm.nih.gov/23468542/","study_design":null,"title":"Screening for predementia AD: time-dependent operating characteristics of episodic memory tests","title_match":false,"year":2013},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/differential-associations-of-plasma-lipids-with-incident-dementia-and-28350817","doi":"10.1371/journal.pmed.1002265","journal":"PLoS medicine","n_participants":9294,"pmid":"28350817","source_url":"https://pubmed.ncbi.nlm.nih.gov/28350817/","study_design":"cohort study","title":"Differential associations of plasma lipids with incident dementia and dementia subtypes in the 3C Study: A longitudinal, population-based prospective cohort study","title_match":false,"year":2017},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/association-of-seafood-consumption-brain-mercury-level-and-apoe-4-26836731","doi":"10.1001/jama.2015.19451","journal":"JAMA","n_participants":286,"pmid":"26836731","source_url":"https://pubmed.ncbi.nlm.nih.gov/26836731/","study_design":"cohort study","title":"Association of Seafood Consumption, Brain Mercury Level, and APOE \u03b54 Status With Brain Neuropathology in Older Adults","title_match":true,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/homocysteine-and-holotranscobalamin-and-the-risk-of-alzheimer-disease-20956786","doi":"10.1212/wnl.0b013e3181f88162","journal":"Neurology","n_participants":271,"pmid":"20956786","source_url":"https://pubmed.ncbi.nlm.nih.gov/20956786/","study_design":null,"title":"Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study","title_match":false,"year":2010},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/association-of-apolipoprotein-e-4-with-transactive-response-dna-30422173","doi":"10.1001/jamaneurol.2018.3139","journal":"JAMA neurology","n_participants":604,"pmid":"30422173","source_url":"https://pubmed.ncbi.nlm.nih.gov/30422173/","study_design":"cross-sectional","title":"Association of Apolipoprotein E \u03b54 With Transactive Response DNA-Binding Protein 43","title_match":true,"year":2018},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/apoe-influences-regional-white-matter-axonal-density-loss-in-28578156","doi":"10.1016/j.neurobiolaging.2017.04.021","journal":"Neurobiology of aging","n_participants":37,"pmid":"28578156","source_url":"https://pubmed.ncbi.nlm.nih.gov/28578156/","study_design":null,"title":"ApoE influences regional white-matter axonal density loss in Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-genetics-of-the-human-apoe-polymorphism-21958003","doi":"10.1089/rej.2011.1169","journal":"Rejuvenation research","n_participants":null,"pmid":"21958003","source_url":"https://pubmed.ncbi.nlm.nih.gov/21958003/","study_design":null,"title":"The genetics of the human APOE polymorphism","title_match":false,"year":2011},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/disturbed-sleep-patterns-in-elders-with-mild-cognitive-impairment-the-22211488","doi":"10.2174/156720512800107609","journal":"Current Alzheimer research","n_participants":null,"pmid":"22211488","source_url":"https://pubmed.ncbi.nlm.nih.gov/22211488/","study_design":null,"title":"Disturbed sleep patterns in elders with mild cognitive impairment: the role of memory decline and ApoE \u03b54 genotype","title_match":true,"year":2012},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/whole-brain-atrophy-rate-in-alzheimer-disease-identifying-fast-18458218","doi":"10.1212/01.wnl.0000311446.61861.e3","journal":"Neurology","n_participants":65,"pmid":"18458218","source_url":"https://pubmed.ncbi.nlm.nih.gov/18458218/","study_design":null,"title":"Whole-brain atrophy rate in Alzheimer disease: identifying fast progressors","title_match":false,"year":2008},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/cognitive-performance-in-older-women-relative-to-apoe-epsilon4-17218903","doi":"10.1249/01.mss.0000239399.85955.5e","journal":"Medicine and science in sports and exercise","n_participants":90,"pmid":"17218903","source_url":"https://pubmed.ncbi.nlm.nih.gov/17218903/","study_design":null,"title":"Cognitive performance in older women relative to ApoE-epsilon4 genotype and aerobic fitness","title_match":true,"year":2007},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/prevalence-of-preclinical-alzheimer-disease-comparison-of-current-29653987","doi":"10.1212/wnl.0000000000005476","journal":"Neurology","n_participants":322,"pmid":"29653987","source_url":"https://pubmed.ncbi.nlm.nih.gov/29653987/","study_design":"cohort study","title":"Prevalence of preclinical Alzheimer disease: Comparison of current classification systems","title_match":false,"year":2018},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/dura-mater-is-a-potential-source-of-a-seeds-27016065","doi":"10.1007/s00401-016-1565-x","journal":"Acta neuropathologica","n_participants":null,"pmid":"27016065","source_url":"https://pubmed.ncbi.nlm.nih.gov/27016065/","study_design":null,"title":"Dura mater is a potential source of A\u03b2 seeds","title_match":false,"year":2016},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/neuropathologic-basis-of-age-associated-brain-atrophy-23552688","doi":"10.1001/jamaneurol.2013.1957","journal":"JAMA neurology","n_participants":null,"pmid":"23552688","source_url":"https://pubmed.ncbi.nlm.nih.gov/23552688/","study_design":"longitudinal study","title":"Neuropathologic basis of age-associated brain atrophy","title_match":false,"year":2013},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/comprehensive-search-for-alzheimer-disease-susceptibility-loci-in-the-22869155","doi":"10.1001/archneurol.2012.2052","journal":"Archives of neurology","n_participants":null,"pmid":"22869155","source_url":"https://pubmed.ncbi.nlm.nih.gov/22869155/","study_design":null,"title":"Comprehensive search for Alzheimer disease susceptibility loci in the APOE region","title_match":false,"year":2012},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/does-nsaid-use-modify-cognitive-trajectories-in-the-elderly-the-cache-17636065","doi":"10.1212/01.wnl.0000265223.25679.2a","journal":"Neurology","n_participants":3383,"pmid":"17636065","source_url":"https://pubmed.ncbi.nlm.nih.gov/17636065/","study_design":null,"title":"Does NSAID use modify cognitive trajectories in the elderly? The Cache County study","title_match":false,"year":2007},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/memory-performance-and-the-apolipoprotein-e-polymorphism-in-a-11121165","doi":"10.1002/1096-8628(20001204)96:6<707::aid-ajmg1>3.0.co;2-v","journal":"American journal of medical genetics","n_participants":null,"pmid":"11121165","source_url":"https://pubmed.ncbi.nlm.nih.gov/11121165/","study_design":null,"title":"Memory performance and the apolipoprotein E polymorphism in a community sample of middle-aged adults","title_match":false,"year":2000},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/association-between-severe-cerebral-amyloid-angiopathy-and-10867785","doi":"10.1001/archneur.57.6.869","journal":"Archives of neurology","n_participants":null,"pmid":"10867785","source_url":"https://pubmed.ncbi.nlm.nih.gov/10867785/","study_design":null,"title":"Association between severe cerebral amyloid angiopathy and cerebrovascular lesions in Alzheimer disease is not a spurious one attributable to apolipoprotein E4","title_match":true,"year":2000},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-genotype-and-the-diagnostic-accuracy-of-25162367","doi":"10.1001/jamapsychiatry.2014.1060","journal":"JAMA psychiatry","n_participants":105,"pmid":"25162367","source_url":"https://pubmed.ncbi.nlm.nih.gov/25162367/","study_design":null,"title":"Apolipoprotein E genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease","title_match":false,"year":2014},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/effect-of-apolipoprotein-e-genotype-and-diet-on-apolipoprotein-e-23779114","doi":"10.1001/jamaneurol.2013.396","journal":"JAMA neurology","n_participants":null,"pmid":"23779114","source_url":"https://pubmed.ncbi.nlm.nih.gov/23779114/","study_design":null,"title":"Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial","title_match":false,"year":2013},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-alzheimer-disease-genotype-specific-risks-by-age-9012418","doi":null,"journal":"American journal of human genetics","n_participants":null,"pmid":"9012418","source_url":"https://pubmed.ncbi.nlm.nih.gov/9012418/","study_design":null,"title":"Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex","title_match":false,"year":1997},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/increased-apoe-4-expression-is-associated-with-the-difference-in-33522086","doi":"10.1002/alz.12287","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":60908,"pmid":"33522086","source_url":"https://pubmed.ncbi.nlm.nih.gov/33522086/","study_design":null,"title":"Increased APOE \u03b54 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds","title_match":true,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/age-varying-association-between-statin-use-and-incident-alzheimer-s-20533968","doi":"10.1111/j.1532-5415.2010.02906.x","journal":"Journal of the American Geriatrics Society","n_participants":3099,"pmid":"20533968","source_url":"https://pubmed.ncbi.nlm.nih.gov/20533968/","study_design":null,"title":"Age-varying association between statin use and incident Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/chronic-kidney-disease-is-associated-with-dementia-independent-of-24553427","doi":"10.1212/wnl.0000000000000251","journal":"Neurology","n_participants":600,"pmid":"24553427","source_url":"https://pubmed.ncbi.nlm.nih.gov/24553427/","study_design":null,"title":"Chronic kidney disease is associated with dementia independent of cerebral small-vessel disease","title_match":false,"year":2014},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/apoe-and-cognitive-decline-in-preclinical-alzheimer-disease-and-non-15365129","doi":"10.1212/01.wnl.0000137041.86153.42","journal":"Neurology","n_participants":null,"pmid":"15365129","source_url":"https://pubmed.ncbi.nlm.nih.gov/15365129/","study_design":null,"title":"APOE and cognitive decline in preclinical Alzheimer disease and non-demented aging","title_match":false,"year":2004},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/apoe-4-worsens-hippocampal-ca1-apical-neuropil-atrophy-and-episodic-24453080","doi":"10.1212/wnl.0000000000000154","journal":"Neurology","n_participants":null,"pmid":"24453080","source_url":"https://pubmed.ncbi.nlm.nih.gov/24453080/","study_design":"cross-sectional","title":"APOE \u03b54 worsens hippocampal CA1 apical neuropil atrophy and episodic memory","title_match":true,"year":2014},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/an-inherited-variable-poly-t-repeat-genotype-in-tomm40-in-alzheimer-20457951","doi":"10.1001/archneurol.2010.88","journal":"Archives of neurology","n_participants":null,"pmid":"20457951","source_url":"https://pubmed.ncbi.nlm.nih.gov/20457951/","study_design":null,"title":"An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease","title_match":false,"year":2010},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/the-apolipoprotein-e-epsilon4-allele-increases-the-odds-of-chronic-15774818","doi":"10.1161/01.str.0000160747.27470.2a","journal":"Stroke","n_participants":96,"pmid":"15774818","source_url":"https://pubmed.ncbi.nlm.nih.gov/15774818/","study_design":"longitudinal study","title":"The apolipoprotein E epsilon4 allele increases the odds of chronic cerebral infarction [corrected] detected at autopsy in older persons","title_match":true,"year":2005},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/aberrant-phosphorylation-of-alpha-synuclein-in-human-niemann-pick-15099022","doi":"10.1093/jnen/63.4.323","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"15099022","source_url":"https://pubmed.ncbi.nlm.nih.gov/15099022/","study_design":null,"title":"Aberrant phosphorylation of alpha-synuclein in human Niemann-Pick type C1 disease","title_match":false,"year":2004},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/cholesterol-atherosclerosis-and-apoe-in-vascular-contributions-to-33841127","doi":"10.3389/fnagi.2021.647990","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"33841127","source_url":"https://pubmed.ncbi.nlm.nih.gov/33841127/","study_design":null,"title":"Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/genetic-heterogeneity-in-alzheimer-disease-and-implications-for-25217249","doi":"10.1007/s11910-014-0499-8","journal":"Current neurology and neuroscience reports","n_participants":null,"pmid":"25217249","source_url":"https://pubmed.ncbi.nlm.nih.gov/25217249/","study_design":null,"title":"Genetic heterogeneity in Alzheimer disease and implications for treatment strategies","title_match":false,"year":2014},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/late-onset-alzheimer-s-risk-variants-in-memory-decline-incident-mild-25189118","doi":"10.1016/j.neurobiolaging.2014.07.042","journal":"Neurobiology of aging","n_participants":null,"pmid":"25189118","source_url":"https://pubmed.ncbi.nlm.nih.gov/25189118/","study_design":null,"title":"Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/progressive-regional-atrophy-in-normal-adults-with-a-maternal-history-21357834","doi":"10.1212/wnl.0b013e31820e7b74","journal":"Neurology","n_participants":null,"pmid":"21357834","source_url":"https://pubmed.ncbi.nlm.nih.gov/21357834/","study_design":"longitudinal study","title":"Progressive regional atrophy in normal adults with a maternal history of Alzheimer disease","title_match":false,"year":2011},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/dissociable-influences-of-i-apoe-i-4-and-polygenic-risk-of-ad-29592889","doi":"10.1212/wnl.0000000000005415","journal":"Neurology","n_participants":702,"pmid":"29592889","source_url":"https://pubmed.ncbi.nlm.nih.gov/29592889/","study_design":"longitudinal study","title":"Dissociable influences of APOE \u03b54 and polygenic risk of AD dementia on amyloid and cognition","title_match":true,"year":2018},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/hippocampal-sclerosis-in-the-elderly-genetic-and-pathologic-findings-21346515","doi":"10.1097/wad.0b013e31820f8f50","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"21346515","source_url":"https://pubmed.ncbi.nlm.nih.gov/21346515/","study_design":null,"title":"Hippocampal sclerosis in the elderly: genetic and pathologic findings, some mimicking Alzheimer disease clinically","title_match":false,"year":2011},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/differential-effects-of-apolipoprotein-e-isoforms-on-metal-induced-10194381","doi":"10.1021/bi982437d","journal":"Biochemistry","n_participants":null,"pmid":"10194381","source_url":"https://pubmed.ncbi.nlm.nih.gov/10194381/","study_design":null,"title":"Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations","title_match":false,"year":1999},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/associations-of-dietary-choline-intake-with-risk-of-incident-dementia-31360988","doi":"10.1093/ajcn/nqz148","journal":"The American journal of clinical nutrition","n_participants":null,"pmid":"31360988","source_url":"https://pubmed.ncbi.nlm.nih.gov/31360988/","study_design":null,"title":"Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study","title_match":false,"year":2019},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/csf-beta-amyloid-1-42-concentration-predicts-delirium-following-31082921","doi":"10.1097/sla.0000000000002684","journal":"Annals of surgery","n_participants":282,"pmid":"31082921","source_url":"https://pubmed.ncbi.nlm.nih.gov/31082921/","study_design":"cohort study","title":"CSF Beta-amyloid 1-42 Concentration Predicts Delirium Following Elective Arthroplasty Surgery in an Observational Cohort Study","title_match":false,"year":2019},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/association-of-rare-apoe-missense-variants-v236e-and-r251g-with-risk-35639372","doi":"10.1001/jamaneurol.2022.1166","journal":"JAMA neurology","n_participants":37,"pmid":"35639372","source_url":"https://pubmed.ncbi.nlm.nih.gov/35639372/","study_design":"case-control study","title":"Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease","title_match":false,"year":2022},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/association-of-brain-amyloid-with-slow-gait-in-elderly-individuals-27842173","doi":"10.1001/jamaneurol.2016.3474","journal":"JAMA neurology","n_participants":183,"pmid":"27842173","source_url":"https://pubmed.ncbi.nlm.nih.gov/27842173/","study_design":"cross-sectional","title":"Association of Brain Amyloid-\u03b2 With Slow Gait in Elderly Individuals Without Dementia: Influence of Cognition and Apolipoprotein E \u03b54 Genotype","title_match":true,"year":2017},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/myo-inositol-changes-precede-amyloid-pathology-and-relate-to-apoe-27164711","doi":"10.1212/wnl.0000000000002672","journal":"Neurology","n_participants":null,"pmid":"27164711","source_url":"https://pubmed.ncbi.nlm.nih.gov/27164711/","study_design":"cross-sectional","title":"Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease","title_match":false,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/amyloid-pathology-and-apoe-genotype-modulate-retinoid-x-receptor-25217640","doi":"10.1074/jbc.m114.600833","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"25217640","source_url":"https://pubmed.ncbi.nlm.nih.gov/25217640/","study_design":null,"title":"Amyloid-\u03b2 pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo","title_match":false,"year":2014},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/longitudinal-modeling-of-frontal-cognition-in-apoe-4-homozygotes-21502596","doi":"10.1212/wnl.0b013e3182167147","journal":"Neurology","n_participants":27,"pmid":"21502596","source_url":"https://pubmed.ncbi.nlm.nih.gov/21502596/","study_design":null,"title":"Longitudinal modeling of frontal cognition in APOE \u03b54 homozygotes, heterozygotes, and noncarriers","title_match":true,"year":2011},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/neuropathologic-intermediate-phenotypes-enhance-association-to-19398704","doi":"10.1212/wnl.0b013e3181a2e87d","journal":"Neurology","n_participants":625,"pmid":"19398704","source_url":"https://pubmed.ncbi.nlm.nih.gov/19398704/","study_design":null,"title":"Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles","title_match":false,"year":2009},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/predictive-utility-of-apolipoprotein-e-genotype-for-alzheimer-disease-15956169","doi":"10.1001/archneur.62.6.975","journal":"Archives of neurology","n_participants":57,"pmid":"15956169","source_url":"https://pubmed.ncbi.nlm.nih.gov/15956169/","study_design":"longitudinal study","title":"Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairment","title_match":false,"year":2005},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/apoe-apolipoprotein-e-in-brain-pericytes-regulates-endothelial-31665905","doi":"10.1161/atvbaha.119.313169","journal":"Arteriosclerosis, thrombosis, and vascular biology","n_participants":null,"pmid":"31665905","source_url":"https://pubmed.ncbi.nlm.nih.gov/31665905/","study_design":null,"title":"ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components","title_match":false,"year":2020},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/modulation-of-apolipoprotein-e-structure-by-domain-interaction-16076841","doi":"10.1074/jbc.m506044200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"16076841","source_url":"https://pubmed.ncbi.nlm.nih.gov/16076841/","study_design":null,"title":"Modulation of apolipoprotein E structure by domain interaction: differences in lipid-bound and lipid-free forms","title_match":false,"year":2005},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/association-of-cardiovascular-risk-trajectory-with-cognitive-decline-35444051","doi":"10.1212/wnl.0000000000200255","journal":"Neurology","n_participants":1244,"pmid":"35444051","source_url":"https://pubmed.ncbi.nlm.nih.gov/35444051/","study_design":"prospective cohort","title":"Association of Cardiovascular Risk Trajectory With Cognitive Decline and Incident Dementia","title_match":false,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/association-of-hypometabolism-and-amyloid-levels-in-aging-normal-24793183","doi":"10.1212/wnl.0000000000000467","journal":"Neurology","n_participants":null,"pmid":"24793183","source_url":"https://pubmed.ncbi.nlm.nih.gov/24793183/","study_design":"cross-sectional","title":"Association of hypometabolism and amyloid levels in aging, normal subjects","title_match":false,"year":2014},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/effects-of-apoe-on-brain-white-matter-microstructure-in-healthy-adults-23100402","doi":"10.1212/wnl.0b013e3182735c9c","journal":"Neurology","n_participants":30,"pmid":"23100402","source_url":"https://pubmed.ncbi.nlm.nih.gov/23100402/","study_design":null,"title":"Effects of APOE on brain white matter microstructure in healthy adults","title_match":false,"year":2012},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/association-of-alzheimer-disease-pathology-with-abnormal-lipid-21911734","doi":"10.1212/wnl.0b013e31822e145d","journal":"Neurology","n_participants":null,"pmid":"21911734","source_url":"https://pubmed.ncbi.nlm.nih.gov/21911734/","study_design":null,"title":"Association of Alzheimer disease pathology with abnormal lipid metabolism: the Hisayama Study","title_match":false,"year":2011},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/quantitation-of-apoe-domains-in-alzheimer-disease-brain-suggests-a-11305869","doi":"10.1093/jnen/60.4.342","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"11305869","source_url":"https://pubmed.ncbi.nlm.nih.gov/11305869/","study_design":null,"title":"Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation","title_match":false,"year":2001},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-epsilon-4-allele-in-alzheimer-s-disease-and-vascular-7951679","doi":"10.1159/000106730","journal":"Dementia (Basel, Switzerland)","n_participants":null,"pmid":"7951679","source_url":"https://pubmed.ncbi.nlm.nih.gov/7951679/","study_design":null,"title":"Apolipoprotein E epsilon 4 allele in Alzheimer's disease and vascular dementia","title_match":false,"year":1994},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/sex-differences-in-csf-biomarkers-vary-by-alzheimer-disease-stage-and-32788242","doi":"10.1212/wnl.0000000000010629","journal":"Neurology","n_participants":1801,"pmid":"32788242","source_url":"https://pubmed.ncbi.nlm.nih.gov/32788242/","study_design":null,"title":"Sex differences in CSF biomarkers vary by Alzheimer disease stage and APOE \u03b54 genotype","title_match":true,"year":2020},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/fatty-acids-lipid-metabolism-and-alzheimer-pathology-18378224","doi":"10.1016/j.ejphar.2007.11.081","journal":"European journal of pharmacology","n_participants":null,"pmid":"18378224","source_url":"https://pubmed.ncbi.nlm.nih.gov/18378224/","study_design":null,"title":"Fatty acids, lipid metabolism and Alzheimer pathology","title_match":false,"year":2008},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/eeg-alterations-in-non-demented-individuals-related-to-apolipoprotein-17293007","doi":"10.1016/j.neurobiolaging.2006.12.019","journal":"Neurobiology of aging","n_participants":145,"pmid":"17293007","source_url":"https://pubmed.ncbi.nlm.nih.gov/17293007/","study_design":null,"title":"EEG alterations in non-demented individuals related to apolipoprotein E genotype and to risk of Alzheimer disease","title_match":false,"year":2008},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/multiple-or-mixed-cerebral-microbleeds-and-dementia-in-patients-with-25015364","doi":"10.1212/wnl.0000000000000692","journal":"Neurology","n_participants":524,"pmid":"25015364","source_url":"https://pubmed.ncbi.nlm.nih.gov/25015364/","study_design":null,"title":"Multiple or mixed cerebral microbleeds and dementia in patients with vascular risk factors","title_match":false,"year":2014},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/correlating-cerebral-hypometabolism-with-future-memory-decline-in-18779428","doi":"10.1001/archneurol.2008.1","journal":"Archives of neurology","n_participants":null,"pmid":"18779428","source_url":"https://pubmed.ncbi.nlm.nih.gov/18779428/","study_design":"longitudinal study","title":"Correlating cerebral hypometabolism with future memory decline in subsequent converters to amnestic pre-mild cognitive impairment","title_match":false,"year":2008},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/predictors-of-conversion-to-dementia-of-probable-alzheimer-type-in-16611017","doi":"10.2174/156720506776383103","journal":"Current Alzheimer research","n_participants":null,"pmid":"16611017","source_url":"https://pubmed.ncbi.nlm.nih.gov/16611017/","study_design":null,"title":"Predictors of conversion to dementia of probable Alzheimer type in patients with mild cognitive impairment","title_match":false,"year":2006},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/obesity-accelerates-alzheimer-related-pathology-in-i-apoe4-i-but-not-28612048","doi":"10.1523/eneuro.0077-17.2017","journal":"eNeuro","n_participants":null,"pmid":"28612048","source_url":"https://pubmed.ncbi.nlm.nih.gov/28612048/","study_design":null,"title":"Obesity Accelerates Alzheimer-Related Pathology in APOE4 but not APOE3 Mice","title_match":true,"year":2017},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/association-between-mentally-stimulating-activities-in-late-life-and-28135351","doi":"10.1001/jamaneurol.2016.3822","journal":"JAMA neurology","n_participants":973,"pmid":"28135351","source_url":"https://pubmed.ncbi.nlm.nih.gov/28135351/","study_design":"cohort study","title":"Association Between Mentally Stimulating Activities in Late Life and the Outcome of Incident Mild Cognitive Impairment, With an Analysis of the APOE \u03b54 Genotype","title_match":true,"year":2017},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/value-of-serum-nonceruloplasmin-copper-for-prediction-of-mild-24623259","doi":"10.1002/ana.24136","journal":"Annals of neurology","n_participants":42,"pmid":"24623259","source_url":"https://pubmed.ncbi.nlm.nih.gov/24623259/","study_design":"meta-analysis","title":"Value of serum nonceruloplasmin copper for prediction of mild cognitive impairment conversion to Alzheimer disease","title_match":false,"year":2014},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-alzheimer-disease-16432152","doi":"10.1212/01.wnl.0000192102.41141.9e","journal":"Neurology","n_participants":null,"pmid":"16432152","source_url":"https://pubmed.ncbi.nlm.nih.gov/16432152/","study_design":null,"title":"Apolipoprotein E and Alzheimer disease","title_match":false,"year":2006},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/specificity-of-brain-activation-patterns-in-people-at-genetic-risk-11790634","doi":"10.1097/00019442-200201000-00006","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":25,"pmid":"11790634","source_url":"https://pubmed.ncbi.nlm.nih.gov/11790634/","study_design":null,"title":"Specificity of brain activation patterns in people at genetic risk for Alzheimer disease","title_match":false,"year":2002},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/association-of-reproductive-history-with-brain-mri-biomarkers-of-34732544","doi":"10.1212/wnl.0000000000012941","journal":"Neurology","n_participants":null,"pmid":"34732544","source_url":"https://pubmed.ncbi.nlm.nih.gov/34732544/","study_design":null,"title":"Association of Reproductive History With Brain MRI Biomarkers of Dementia Risk in Midlife","title_match":false,"year":2021},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/dissection-of-synaptic-pathways-through-the-csf-biomarkers-for-32586895","doi":"10.1212/wnl.0000000000010131","journal":"Neurology","n_participants":81,"pmid":"32586895","source_url":"https://pubmed.ncbi.nlm.nih.gov/32586895/","study_design":"cross-sectional","title":"Dissection of synaptic pathways through the CSF biomarkers for predicting Alzheimer disease","title_match":false,"year":2020},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/clinical-predictors-of-severe-cerebral-amyloid-angiopathy-and-24797962","doi":"10.1001/jamaneurol.2014.681","journal":"JAMA neurology","n_participants":193,"pmid":"24797962","source_url":"https://pubmed.ncbi.nlm.nih.gov/24797962/","study_design":"longitudinal study","title":"Clinical predictors of severe cerebral amyloid angiopathy and influence of APOE genotype in persons with pathologically verified Alzheimer disease","title_match":false,"year":2014},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-amyloid-beta-and-blood-brain-barrier-permeability-in-18379441","doi":"10.1097/nen.0b013e31816a0dc8","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"18379441","source_url":"https://pubmed.ncbi.nlm.nih.gov/18379441/","study_design":null,"title":"Apolipoprotein E, amyloid-beta, and blood-brain barrier permeability in Alzheimer disease","title_match":false,"year":2008},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/a-genome-survey-for-novel-alzheimer-disease-risk-loci-results-at-10-9653640","doi":"10.1006/geno.1998.5306","journal":"Genomics","n_participants":null,"pmid":"9653640","source_url":"https://pubmed.ncbi.nlm.nih.gov/9653640/","study_design":null,"title":"A genome survey for novel Alzheimer disease risk loci: results at 10-cM resolution","title_match":false,"year":1998},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/regional-cerebral-perfusion-in-patients-with-alzheimer-s-disease-and-22828738","doi":"10.1007/s00234-012-1077-x","journal":"Neuroradiology","n_participants":null,"pmid":"22828738","source_url":"https://pubmed.ncbi.nlm.nih.gov/22828738/","study_design":null,"title":"Regional cerebral perfusion in patients with Alzheimer's disease and mild cognitive impairment: effect of APOE epsilon4 allele","title_match":true,"year":2013},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/double-blind-placebo-controlled-study-with-citicoline-in-apoe-10669911","doi":"10.1358/mf.1999.21.9.795632","journal":"Methods and findings in experimental and clinical pharmacology","n_participants":17,"pmid":"10669911","source_url":"https://pubmed.ncbi.nlm.nih.gov/10669911/","study_design":null,"title":"Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity and cerebral perfusion","title_match":false,"year":1999},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/neuron-derived-extracellular-vesicles-in-blood-reveal-effects-of-37730689","doi":"10.1186/s13195-023-01303-9","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"37730689","source_url":"https://pubmed.ncbi.nlm.nih.gov/37730689/","study_design":"randomized controlled trial","title":"Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/low-dose-ladostigil-for-mild-cognitive-impairment-a-phase-2-placebo-31492718","doi":"10.1212/wnl.0000000000008239","journal":"Neurology","n_participants":107,"pmid":"31492718","source_url":"https://pubmed.ncbi.nlm.nih.gov/31492718/","study_design":"clinical trial","title":"Low-dose ladostigil for mild cognitive impairment: A phase 2 placebo-controlled clinical trial","title_match":false,"year":2019},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/amyloid-related-imaging-abnormalities-aria-in-clinical-trials-of-39556389","doi":"10.1001/jamaneurol.2024.3937","journal":"JAMA neurology","n_participants":985,"pmid":"39556389","source_url":"https://pubmed.ncbi.nlm.nih.gov/39556389/","study_design":"clinical trial","title":"Amyloid-Related Imaging Abnormalities (ARIA) in Clinical Trials of Gantenerumab in Early Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/dha-rich-n-3-fatty-acid-supplementation-decreases-dna-methylation-in-28855224","doi":"10.3945/ajcn.117.155648","journal":"The American journal of clinical nutrition","n_participants":63,"pmid":"28855224","source_url":"https://pubmed.ncbi.nlm.nih.gov/28855224/","study_design":null,"title":"DHA-rich n-3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study","title_match":false,"year":2017},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/genetic-susceptibility-testing-versus-family-history-based-risk-15654228","doi":"10.1097/01.gim.0000151157.13716.6c","journal":"Genetics in medicine : official journal of the American College of Medical Genetics","n_participants":30,"pmid":"15654228","source_url":"https://pubmed.ncbi.nlm.nih.gov/15654228/","study_design":null,"title":"Genetic susceptibility testing versus family history-based risk assessment: Impact on perceived risk of Alzheimer disease","title_match":false,"year":2005},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/is-more-always-better-dose-effect-in-a-multidomain-intervention-in-35049127","doi":"10.1002/alz.12544","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":749,"pmid":"35049127","source_url":"https://pubmed.ncbi.nlm.nih.gov/35049127/","study_design":"randomized controlled trial","title":"Is more always better? Dose effect in a multidomain intervention in older adults at risk of dementia","title_match":false,"year":2022},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/slowing-cognitive-decline-in-major-depressive-disorder-and-mild-39476073","doi":"10.1001/jamapsychiatry.2024.3241","journal":"JAMA psychiatry","n_participants":null,"pmid":"39476073","source_url":"https://pubmed.ncbi.nlm.nih.gov/39476073/","study_design":null,"title":"Slowing Cognitive Decline in Major Depressive Disorder and Mild Cognitive Impairment: A Randomized Clinical Trial","title_match":false,"year":2025},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/disclosing-pleiotropic-effects-during-genetic-risk-assessment-for-26810768","doi":"10.7326/m15-0187","journal":"Annals of internal medicine","n_participants":null,"pmid":"26810768","source_url":"https://pubmed.ncbi.nlm.nih.gov/26810768/","study_design":null,"title":"Disclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial","title_match":false,"year":2016},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/prevention-of-cognitive-decline-in-subjective-cognitive-decline-apoe-33816762","doi":"10.1002/trc2.12155","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":200,"pmid":"33816762","source_url":"https://pubmed.ncbi.nlm.nih.gov/33816762/","study_design":null,"title":"Prevention of cognitive decline in subjective cognitive decline APOE \u03b54 carriers after EGCG and a multimodal intervention (PENSA): Study design","title_match":true,"year":2021},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/effect-of-simvastatin-on-csf-alzheimer-disease-biomarkers-in-28821686","doi":"10.1212/wnl.0000000000004392","journal":"Neurology","n_participants":null,"pmid":"28821686","source_url":"https://pubmed.ncbi.nlm.nih.gov/28821686/","study_design":null,"title":"Effect of simvastatin on CSF Alzheimer disease biomarkers in cognitively normal adults","title_match":false,"year":2017},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/association-of-sleep-disordered-breathing-and-medial-temporal-lobe-37258299","doi":"10.1212/wnl.0000000000207421","journal":"Neurology","n_participants":122,"pmid":"37258299","source_url":"https://pubmed.ncbi.nlm.nih.gov/37258299/","study_design":"randomized controlled trial","title":"Association of Sleep-Disordered Breathing and Medial Temporal Lobe Atrophy in Cognitively Unimpaired Amyloid-Positive Older Adults","title_match":false,"year":2023},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/incidence-of-amyloid-related-imaging-abnormalities-in-phase-iii-40112274","doi":"10.1212/wnl.0000000000213483","journal":"Neurology","n_participants":6315,"pmid":"40112274","source_url":"https://pubmed.ncbi.nlm.nih.gov/40112274/","study_design":"meta-analysis","title":"Incidence of Amyloid-Related Imaging Abnormalities in Phase III Clinical Trials of Anti-Amyloid-\u03b2 Immunotherapy: An Updated Meta-Analysis","title_match":false,"year":2025},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/3-pufa-for-secondary-prevention-of-white-matter-lesions-and-neuronal-39088212","doi":"10.1001/jamanetworkopen.2024.26872","journal":"JAMA network open","n_participants":102,"pmid":"39088212","source_url":"https://pubmed.ncbi.nlm.nih.gov/39088212/","study_design":null,"title":"\u03c9-3 PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older Adults: A Randomized Clinical Trial","title_match":false,"year":2024},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/trajectory-of-the-mapt-pacc-preclinical-alzheimer-cognitive-composite-29405230","doi":"10.14283/jpad.2017.21","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"29405230","source_url":"https://pubmed.ncbi.nlm.nih.gov/29405230/","study_design":"randomized controlled trial","title":"Trajectory of the MAPT-PACC-Preclinical Alzheimer Cognitive Composite in the Placebo Group of a Randomized Control Trial: Results from the MAPT Study: Lessons for Further Trials","title_match":false,"year":2018},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/citalopram-for-the-treatment-of-agitation-in-alzheimer-dementia-26303700","doi":"10.1177/0891988715601735","journal":"Journal of geriatric psychiatry and neurology","n_participants":null,"pmid":"26303700","source_url":"https://pubmed.ncbi.nlm.nih.gov/26303700/","study_design":null,"title":"Citalopram for the Treatment of Agitation in Alzheimer Dementia: Genetic Influences","title_match":false,"year":2016},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/pulse-pressure-as-a-predictor-of-alzheimer-s-disease-biomarkers-and-40908201","doi":"10.1016/j.tjpad.2025.100363","journal":"The journal of prevention of Alzheimer's disease","n_participants":1690,"pmid":"40908201","source_url":"https://pubmed.ncbi.nlm.nih.gov/40908201/","study_design":"cohort study","title":"Pulse pressure as a predictor of Alzheimer's disease biomarkers and cognitive decline: The moderating role of APOE \u03b54","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/apoe-genotype-disclosure-and-lifestyle-advice-in-a-randomized-33188400","doi":"10.1093/jn/nxaa316","journal":"The Journal of nutrition","n_participants":33,"pmid":"33188400","source_url":"https://pubmed.ncbi.nlm.nih.gov/33188400/","study_design":null,"title":"APOE Genotype Disclosure and Lifestyle Advice in a Randomized Intervention Study with Finnish Participants","title_match":false,"year":2021},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-4-dependent-associations-between-carotenoids-and-40876538","doi":"10.1016/j.ajcnut.2025.08.012","journal":"The American journal of clinical nutrition","n_participants":442,"pmid":"40876538","source_url":"https://pubmed.ncbi.nlm.nih.gov/40876538/","study_design":"randomized controlled trial","title":"Apolipoprotein E \u03b54-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention for Neurodegenerative delay) randomized controlled trial","title_match":true,"year":2025},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/exercise-is-associated-with-reduced-risk-for-incident-dementia-among-16418406","doi":"10.7326/0003-4819-144-2-200601170-00004","journal":"Annals of internal medicine","n_participants":1740,"pmid":"16418406","source_url":"https://pubmed.ncbi.nlm.nih.gov/16418406/","study_design":"cohort study","title":"Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older","title_match":false,"year":2006},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-and-vascular-dementia-in-developing-countries-18667359","doi":"10.1016/s1474-4422(08)70169-8","journal":"The Lancet. Neurology","n_participants":null,"pmid":"18667359","source_url":"https://pubmed.ncbi.nlm.nih.gov/18667359/","study_design":null,"title":"Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors","title_match":false,"year":2008},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/incidence-of-dementia-over-three-decades-in-the-framingham-heart-study-26863354","doi":"10.1056/nejmoa1504327","journal":"The New England journal of medicine","n_participants":5205,"pmid":"26863354","source_url":"https://pubmed.ncbi.nlm.nih.gov/26863354/","study_design":null,"title":"Incidence of Dementia over Three Decades in the Framingham Heart Study","title_match":false,"year":2016},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/associations-between-midlife-vascular-risk-factors-and-25-year-28783817","doi":"10.1001/jamaneurol.2017.1658","journal":"JAMA neurology","n_participants":744,"pmid":"28783817","source_url":"https://pubmed.ncbi.nlm.nih.gov/28783817/","study_design":"prospective cohort","title":"Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort","title_match":false,"year":2017},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/plasma-phosphatidylcholine-docosahexaenoic-acid-content-and-risk-of-17101822","doi":"10.1001/archneur.63.11.1545","journal":"Archives of neurology","n_participants":null,"pmid":"17101822","source_url":"https://pubmed.ncbi.nlm.nih.gov/17101822/","study_design":null,"title":"Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study","title_match":false,"year":2006},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/exceptionally-low-likelihood-of-alzheimer-s-dementia-in-apoe2-32015339","doi":"10.1038/s41467-019-14279-8","journal":"Nature communications","n_participants":null,"pmid":"32015339","source_url":"https://pubmed.ncbi.nlm.nih.gov/32015339/","study_design":null,"title":"Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study","title_match":false,"year":2020},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/caloric-intake-and-the-risk-of-alzheimer-disease-12164721","doi":"10.1001/archneur.59.8.1258","journal":"Archives of neurology","n_participants":980,"pmid":"12164721","source_url":"https://pubmed.ncbi.nlm.nih.gov/12164721/","study_design":null,"title":"Caloric intake and the risk of Alzheimer disease","title_match":false,"year":2002},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/risk-factors-associated-with-the-onset-and-progression-of-alzheimer-s-28363508","doi":"10.1016/j.neuro.2017.03.006","journal":"Neurotoxicology","n_participants":65,"pmid":"28363508","source_url":"https://pubmed.ncbi.nlm.nih.gov/28363508/","study_design":"systematic review","title":"Risk factors associated with the onset and progression of Alzheimer's disease: A systematic review of the evidence","title_match":false,"year":2017},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/midlife-coffee-and-tea-drinking-and-the-risk-of-late-life-dementia-a-19158424","doi":"10.3233/jad-2009-0920","journal":"Journal of Alzheimer's disease : JAD","n_participants":1409,"pmid":"19158424","source_url":"https://pubmed.ncbi.nlm.nih.gov/19158424/","study_design":null,"title":"Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study","title_match":false,"year":2009},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/hypertension-and-the-risk-of-mild-cognitive-impairment-18071036","doi":"10.1001/archneur.64.12.1734","journal":"Archives of neurology","n_participants":918,"pmid":"18071036","source_url":"https://pubmed.ncbi.nlm.nih.gov/18071036/","study_design":"cohort study","title":"Hypertension and the risk of mild cognitive impairment","title_match":false,"year":2007},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/design-and-first-baseline-data-of-the-dzne-multicenter-observational-29415768","doi":"10.1186/s13195-017-0314-2","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"29415768","source_url":"https://pubmed.ncbi.nlm.nih.gov/29415768/","study_design":"longitudinal study","title":"Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer's disease (DELCODE)","title_match":false,"year":2018},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/interactive-associations-of-vascular-risk-and-amyloid-burden-with-29799986","doi":"10.1001/jamaneurol.2018.1123","journal":"JAMA neurology","n_participants":223,"pmid":"29799986","source_url":"https://pubmed.ncbi.nlm.nih.gov/29799986/","study_design":"longitudinal study","title":"Interactive Associations of Vascular Risk and \u03b2-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals: Findings From the Harvard Aging Brain Study","title_match":false,"year":2018},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-epsilon4-magnifies-lifestyle-risks-for-dementia-a-18318693","doi":"10.1111/j.1582-4934.2008.00296.x","journal":"Journal of cellular and molecular medicine","n_participants":1449,"pmid":"18318693","source_url":"https://pubmed.ncbi.nlm.nih.gov/18318693/","study_design":null,"title":"Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study","title_match":true,"year":2008},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/education-and-dementia-what-lies-behind-the-association-17909157","doi":"10.1212/01.wnl.0000277456.29440.16","journal":"Neurology","n_participants":1449,"pmid":"17909157","source_url":"https://pubmed.ncbi.nlm.nih.gov/17909157/","study_design":null,"title":"Education and dementia: what lies behind the association?","title_match":false,"year":2007},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/vascular-basis-for-brain-degeneration-faltering-controls-and-risk-21091952","doi":"10.1111/j.1753-4887.2010.00352.x","journal":"Nutrition reviews","n_participants":null,"pmid":"21091952","source_url":"https://pubmed.ncbi.nlm.nih.gov/21091952/","study_design":null,"title":"Vascular basis for brain degeneration: faltering controls and risk factors for dementia","title_match":false,"year":2010},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/fat-intake-at-midlife-and-risk-of-dementia-and-alzheimer-s-disease-a-16710090","doi":"10.1159/000093478","journal":"Dementia and geriatric cognitive disorders","n_participants":117,"pmid":"16710090","source_url":"https://pubmed.ncbi.nlm.nih.gov/16710090/","study_design":null,"title":"Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study","title_match":false,"year":2006},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/predicting-alzheimer-disease-with-amyloid-imaging-results-from-the-24448836","doi":"10.1002/ana.24040","journal":"Annals of neurology","n_participants":87,"pmid":"24448836","source_url":"https://pubmed.ncbi.nlm.nih.gov/24448836/","study_design":null,"title":"Predicting Alzheimer disease with \u03b2-amyloid imaging: results from the Australian imaging, biomarkers, and lifestyle study of ageing","title_match":false,"year":2013},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/effect-of-the-apolipoprotein-e-genotype-on-cognitive-change-during-a-29356827","doi":"10.1001/jamaneurol.2017.4365","journal":"JAMA neurology","n_participants":1260,"pmid":"29356827","source_url":"https://pubmed.ncbi.nlm.nih.gov/29356827/","study_design":null,"title":"Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial","title_match":false,"year":2018},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/risk-of-dementia-in-elderly-patients-with-the-use-of-proton-pump-25341874","doi":"10.1007/s00406-014-0554-0","journal":"European archives of psychiatry and clinical neuroscience","n_participants":431,"pmid":"25341874","source_url":"https://pubmed.ncbi.nlm.nih.gov/25341874/","study_design":"cohort study","title":"Risk of dementia in elderly patients with the use of proton pump inhibitors","title_match":false,"year":2015},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/designing-prevention-programmes-to-reduce-incidence-of-dementia-20688841","doi":"10.1136/bmj.c3885","journal":"BMJ (Clinical research ed.)","n_participants":1433,"pmid":"20688841","source_url":"https://pubmed.ncbi.nlm.nih.gov/20688841/","study_design":"cohort study","title":"Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors","title_match":false,"year":2010},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/white-matter-changes-in-dementia-role-of-impaired-drainage-of-25521178","doi":"10.1111/bpa.12218","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"25521178","source_url":"https://pubmed.ncbi.nlm.nih.gov/25521178/","study_design":null,"title":"White matter changes in dementia: role of impaired drainage of interstitial fluid","title_match":false,"year":2015},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/predicting-risk-of-dementia-in-older-adults-the-late-life-dementia-19439724","doi":"10.1212/wnl.0b013e3181a81636","journal":"Neurology","n_participants":480,"pmid":"19439724","source_url":"https://pubmed.ncbi.nlm.nih.gov/19439724/","study_design":null,"title":"Predicting risk of dementia in older adults: The late-life dementia risk index","title_match":false,"year":2009},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/omega-3-fatty-acids-and-dementia-19523795","doi":"10.1016/j.plefa.2009.05.015","journal":"Prostaglandins, leukotrienes, and essential fatty acids","n_participants":null,"pmid":"19523795","source_url":"https://pubmed.ncbi.nlm.nih.gov/19523795/","study_design":null,"title":"Omega-3 fatty acids and dementia","title_match":false,"year":2009},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/a-change-in-sleep-pattern-may-predict-alzheimer-disease-23954041","doi":"10.1016/j.jagp.2013.04.015","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":null,"pmid":"23954041","source_url":"https://pubmed.ncbi.nlm.nih.gov/23954041/","study_design":"longitudinal study","title":"A change in sleep pattern may predict Alzheimer disease","title_match":false,"year":2014},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/mental-and-physical-activities-delay-cognitive-decline-in-older-23582750","doi":"10.1016/j.jagp.2013.01.060","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":null,"pmid":"23582750","source_url":"https://pubmed.ncbi.nlm.nih.gov/23582750/","study_design":"open-label trial","title":"Mental and physical activities delay cognitive decline in older persons with dementia","title_match":false,"year":2014},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/vascular-dementia-incidence-and-risk-factors-in-the-canadian-study-of-10884442","doi":"10.1161/01.str.31.7.1487","journal":"Stroke","n_participants":8623,"pmid":"10884442","source_url":"https://pubmed.ncbi.nlm.nih.gov/10884442/","study_design":"case-control study","title":"Vascular dementia : incidence and risk factors in the Canadian study of health and aging","title_match":false,"year":2000},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/age-related-cognitive-decline-and-associations-with-sex-education-and-28323832","doi":"10.1371/journal.pmed.1002261","journal":"PLoS medicine","n_participants":42170,"pmid":"28323832","source_url":"https://pubmed.ncbi.nlm.nih.gov/28323832/","study_design":"cohort study","title":"Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study","title_match":false,"year":2017},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/higher-risk-of-dementia-in-english-older-individuals-who-are-32575116","doi":"10.1093/ije/dyaa099","journal":"International journal of epidemiology","n_participants":453,"pmid":"32575116","source_url":"https://pubmed.ncbi.nlm.nih.gov/32575116/","study_design":"longitudinal study","title":"Higher risk of dementia in English older individuals who are overweight or obese","title_match":false,"year":2020},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/heart-diseases-and-long-term-risk-of-dementia-and-alzheimer-s-disease-24825565","doi":"10.3233/jad-132363","journal":"Journal of Alzheimer's disease : JAD","n_participants":2000,"pmid":"24825565","source_url":"https://pubmed.ncbi.nlm.nih.gov/24825565/","study_design":null,"title":"Heart diseases and long-term risk of dementia and Alzheimer's disease: a population-based CAIDE study","title_match":false,"year":2014},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/multimorbidity-burden-and-dementia-risk-in-older-adults-the-role-of-33403740","doi":"10.1002/alz.12237","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":2478,"pmid":"33403740","source_url":"https://pubmed.ncbi.nlm.nih.gov/33403740/","study_design":null,"title":"Multimorbidity burden and dementia risk in older adults: The role of inflammation and genetics","title_match":false,"year":2021},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/gene-environment-interactions-in-alzheimer-s-disease-a-potential-path-30877021","doi":"10.1016/j.pharmthera.2019.03.005","journal":"Pharmacology & therapeutics","n_participants":null,"pmid":"30877021","source_url":"https://pubmed.ncbi.nlm.nih.gov/30877021/","study_design":null,"title":"Gene-environment interactions in Alzheimer's disease: A potential path to precision medicine","title_match":false,"year":2019},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-in-general-practice-age-specific-prevalence-17848793","doi":"10.1159/000108099","journal":"Dementia and geriatric cognitive disorders","n_participants":3327,"pmid":"17848793","source_url":"https://pubmed.ncbi.nlm.nih.gov/17848793/","study_design":null,"title":"Mild cognitive impairment in general practice: age-specific prevalence and correlate results from the German study on ageing, cognition and dementia in primary care patients (AgeCoDe)","title_match":false,"year":2007},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/midlife-dietary-intake-of-antioxidants-and-risk-of-late-life-incident-15128608","doi":"10.1093/aje/kwh124","journal":"American journal of epidemiology","n_participants":2459,"pmid":"15128608","source_url":"https://pubmed.ncbi.nlm.nih.gov/15128608/","study_design":null,"title":"Midlife dietary intake of antioxidants and risk of late-life incident dementia: the Honolulu-Asia Aging Study","title_match":false,"year":2004},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/multi-method-investigation-of-factors-influencing-amyloid-onset-and-35856240","doi":"10.1093/brain/awac213","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"35856240","source_url":"https://pubmed.ncbi.nlm.nih.gov/35856240/","study_design":"longitudinal study","title":"Multi-method investigation of factors influencing amyloid onset and impairment in three cohorts","title_match":false,"year":2022},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/association-between-midlife-risk-factors-and-late-onset-epilepsy-30039175","doi":"10.1001/jamaneurol.2018.1935","journal":"JAMA neurology","n_participants":792,"pmid":"30039175","source_url":"https://pubmed.ncbi.nlm.nih.gov/30039175/","study_design":"cohort study","title":"Association Between Midlife Risk Factors and Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study","title_match":false,"year":2018},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/cognitive-effects-of-intentional-weight-loss-in-elderly-obese-26713821","doi":"10.1210/jc.2015-2315","journal":"The Journal of clinical endocrinology and metabolism","n_participants":40,"pmid":"26713821","source_url":"https://pubmed.ncbi.nlm.nih.gov/26713821/","study_design":null,"title":"Cognitive Effects of Intentional Weight Loss in Elderly Obese Individuals With Mild Cognitive Impairment","title_match":false,"year":2016},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/dietary-niacin-and-the-risk-of-incident-alzheimer-s-disease-and-of-15258207","doi":"10.1136/jnnp.2003.025858","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":3718,"pmid":"15258207","source_url":"https://pubmed.ncbi.nlm.nih.gov/15258207/","study_design":null,"title":"Dietary niacin and the risk of incident Alzheimer's disease and of cognitive decline","title_match":false,"year":2004},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/amyloid-related-imaging-abnormalities-with-anti-amyloid-antibodies-35401412","doi":"10.3389/fneur.2022.862369","journal":"Frontiers in neurology","n_participants":null,"pmid":"35401412","source_url":"https://pubmed.ncbi.nlm.nih.gov/35401412/","study_design":null,"title":"Amyloid-Related Imaging Abnormalities With Anti-amyloid Antibodies for the Treatment of Dementia Due to Alzheimer's Disease","title_match":false,"year":2022},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/hormone-replacement-therapy-is-associated-with-improved-cognition-and-36624497","doi":"10.1186/s13195-022-01121-5","journal":"Alzheimer's research & therapy","n_participants":1906,"pmid":"36624497","source_url":"https://pubmed.ncbi.nlm.nih.gov/36624497/","study_design":null,"title":"Hormone replacement therapy is associated with improved cognition and larger brain volumes in at-risk APOE4 women: results from the European Prevention of Alzheimer's Disease (EPAD) cohort","title_match":true,"year":2023},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/determinants-of-cognitive-performance-and-decline-in-20-diverse-ethno-31335910","doi":"10.1371/journal.pmed.1002853","journal":"PLoS medicine","n_participants":48522,"pmid":"31335910","source_url":"https://pubmed.ncbi.nlm.nih.gov/31335910/","study_design":"meta-analysis","title":"Determinants of cognitive performance and decline in 20 diverse ethno-regional groups: A COSMIC collaboration cohort study","title_match":false,"year":2019},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/i-apoe-i-genotype-and-early-amyloid-accumulation-in-older-adults-28794245","doi":"10.1212/wnl.0000000000004336","journal":"Neurology","n_participants":325,"pmid":"28794245","source_url":"https://pubmed.ncbi.nlm.nih.gov/28794245/","study_design":"longitudinal study","title":"APOE genotype and early \u03b2-amyloid accumulation in older adults without dementia","title_match":false,"year":2017},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-a-comprehensive-review-of-epidemiology-risk-39736972","doi":"10.3389/fmed.2024.1474043","journal":"Frontiers in medicine","n_participants":null,"pmid":"39736972","source_url":"https://pubmed.ncbi.nlm.nih.gov/39736972/","study_design":null,"title":"Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges","title_match":false,"year":2024},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/participation-in-cognitively-stimulating-activities-and-risk-of-11851541","doi":"10.1001/jama.287.6.742","journal":"JAMA","n_participants":111,"pmid":"11851541","source_url":"https://pubmed.ncbi.nlm.nih.gov/11851541/","study_design":"cohort study","title":"Participation in cognitively stimulating activities and risk of incident Alzheimer disease","title_match":false,"year":2002},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/mild-cognitive-impairment-can-be-distinguished-from-alzheimer-disease-14732621","doi":"10.1001/archneur.61.1.59","journal":"Archives of neurology","n_participants":769,"pmid":"14732621","source_url":"https://pubmed.ncbi.nlm.nih.gov/14732621/","study_design":null,"title":"Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials","title_match":false,"year":2004},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/documented-head-injury-in-early-adulthood-and-risk-of-alzheimer-s-11071494","doi":"10.1212/wnl.55.8.1158","journal":"Neurology","n_participants":null,"pmid":"11071494","source_url":"https://pubmed.ncbi.nlm.nih.gov/11071494/","study_design":null,"title":"Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias","title_match":false,"year":2000},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-status-as-a-predictor-of-the-development-of-7646655","doi":"10.1001/jama.1995.03520400044042","journal":"JAMA","n_participants":66,"pmid":"7646655","source_url":"https://pubmed.ncbi.nlm.nih.gov/7646655/","study_design":"longitudinal study","title":"Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals","title_match":false,"year":1995},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-epidemiology-and-clinical-progression-35286590","doi":"10.1007/s40120-022-00338-8","journal":"Neurology and therapy","n_participants":null,"pmid":"35286590","source_url":"https://pubmed.ncbi.nlm.nih.gov/35286590/","study_design":null,"title":"Alzheimer's Disease: Epidemiology and Clinical Progression","title_match":false,"year":2022},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/neuropathologic-substrates-of-parkinson-disease-dementia-23037886","doi":"10.1002/ana.23659","journal":"Annals of neurology","n_participants":null,"pmid":"23037886","source_url":"https://pubmed.ncbi.nlm.nih.gov/23037886/","study_design":null,"title":"Neuropathologic substrates of Parkinson disease dementia","title_match":false,"year":2012},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/the-behavioural-dysexecutive-variant-of-alzheimer-s-disease-clinical-26141491","doi":"10.1093/brain/awv191","journal":"Brain : a journal of neurology","n_participants":17,"pmid":"26141491","source_url":"https://pubmed.ncbi.nlm.nih.gov/26141491/","study_design":null,"title":"The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features","title_match":false,"year":2015},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/plasma-exosomal-mirnas-in-persons-with-and-without-alzheimer-disease-26426747","doi":"10.1371/journal.pone.0139233","journal":"PloS one","n_participants":35,"pmid":"26426747","source_url":"https://pubmed.ncbi.nlm.nih.gov/26426747/","study_design":null,"title":"Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers","title_match":false,"year":2015},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/utility-of-the-apolipoprotein-e-genotype-in-the-diagnosis-of-9468467","doi":"10.1056/nejm199802193380804","journal":"The New England journal of medicine","n_participants":2188,"pmid":"9468467","source_url":"https://pubmed.ncbi.nlm.nih.gov/9468467/","study_design":null,"title":"Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease","title_match":false,"year":1998},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/reversion-from-mild-cognitive-impairment-to-normal-or-near-normal-23019264","doi":"10.1212/wnl.0b013e31826e26b7","journal":"Neurology","n_participants":3020,"pmid":"23019264","source_url":"https://pubmed.ncbi.nlm.nih.gov/23019264/","study_design":null,"title":"Reversion from mild cognitive impairment to normal or near-normal cognition: risk factors and prognosis","title_match":false,"year":2012},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/high-cerebrospinal-fluid-tau-and-low-amyloid-beta42-levels-in-the-9678311","doi":"10.1001/archneur.55.7.937","journal":"Archives of neurology","n_participants":74,"pmid":"9678311","source_url":"https://pubmed.ncbi.nlm.nih.gov/9678311/","study_design":"cohort study","title":"High cerebrospinal fluid tau and low amyloid beta42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype","title_match":false,"year":1998},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/sex-differences-in-alzheimer-risk-brain-imaging-of-endocrine-vs-28855400","doi":"10.1212/wnl.0000000000004425","journal":"Neurology","n_participants":null,"pmid":"28855400","source_url":"https://pubmed.ncbi.nlm.nih.gov/28855400/","study_design":null,"title":"Sex differences in Alzheimer risk: Brain imaging of endocrine vs chronologic aging","title_match":false,"year":2017},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/prospective-study-of-alcohol-consumption-and-risk-of-dementia-in-12636463","doi":"10.1001/jama.289.11.1405","journal":"JAMA","n_participants":5888,"pmid":"12636463","source_url":"https://pubmed.ncbi.nlm.nih.gov/12636463/","study_design":"cohort study","title":"Prospective study of alcohol consumption and risk of dementia in older adults","title_match":false,"year":2003},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/choroid-plexus-volume-and-permeability-at-brain-mri-within-the-35579521","doi":"10.1148/radiol.212400","journal":"Radiology","n_participants":532,"pmid":"35579521","source_url":"https://pubmed.ncbi.nlm.nih.gov/35579521/","study_design":null,"title":"Choroid Plexus Volume and Permeability at Brain MRI within the Alzheimer Disease Clinical Spectrum","title_match":false,"year":2022},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/magnetic-resonance-images-implicate-that-glymphatic-alterations-36214568","doi":"10.1002/ana.26516","journal":"Annals of neurology","n_participants":50,"pmid":"36214568","source_url":"https://pubmed.ncbi.nlm.nih.gov/36214568/","study_design":null,"title":"Magnetic Resonance Images Implicate That Glymphatic Alterations Mediate Cognitive Dysfunction in Alzheimer Disease","title_match":false,"year":2023},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/type-2-diabetes-mellitus-and-biomarkers-of-neurodegeneration-26333802","doi":"10.1212/wnl.0000000000001982","journal":"Neurology","n_participants":816,"pmid":"26333802","source_url":"https://pubmed.ncbi.nlm.nih.gov/26333802/","study_design":"cross-sectional","title":"Type 2 diabetes mellitus and biomarkers of neurodegeneration","title_match":false,"year":2015},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-4-and-age-effects-on-florbetapir-positron-emission-22633529","doi":"10.1016/j.neurobiolaging.2012.04.017","journal":"Neurobiology of aging","n_participants":245,"pmid":"22633529","source_url":"https://pubmed.ncbi.nlm.nih.gov/22633529/","study_design":null,"title":"Apolipoprotein E \u03b54 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease","title_match":true,"year":2013},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/vascular-burden-and-alzheimer-disease-pathologic-progression-22972646","doi":"10.1212/wnl.0b013e31826c1b9d","journal":"Neurology","n_participants":null,"pmid":"22972646","source_url":"https://pubmed.ncbi.nlm.nih.gov/22972646/","study_design":"longitudinal study","title":"Vascular burden and Alzheimer disease pathologic progression","title_match":false,"year":2012},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/association-of-age-at-menopause-and-hormone-therapy-use-with-tau-and-37010830","doi":"10.1001/jamaneurol.2023.0455","journal":"JAMA neurology","n_participants":null,"pmid":"37010830","source_url":"https://pubmed.ncbi.nlm.nih.gov/37010830/","study_design":"cross-sectional","title":"Association of Age at Menopause and Hormone Therapy Use With Tau and \u03b2-Amyloid Positron Emission Tomography","title_match":false,"year":2023},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-levels-and-the-risk-of-ad-in-normal-subjects-in-the-18401021","doi":"10.1212/01.wnl.0000306696.82017.66","journal":"Neurology","n_participants":55,"pmid":"18401021","source_url":"https://pubmed.ncbi.nlm.nih.gov/18401021/","study_design":"cross-sectional","title":"Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study","title_match":false,"year":2008},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/bone-density-and-brain-atrophy-in-early-alzheimer-s-disease-19661621","doi":"10.3233/jad-2009-1185","journal":"Journal of Alzheimer's disease : JAD","n_participants":71,"pmid":"19661621","source_url":"https://pubmed.ncbi.nlm.nih.gov/19661621/","study_design":null,"title":"Bone density and brain atrophy in early Alzheimer's disease","title_match":false,"year":2009},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/amyloid-related-imaging-abnormalities-an-update-36321981","doi":"10.2214/ajr.22.28461","journal":"AJR. American journal of roentgenology","n_participants":null,"pmid":"36321981","source_url":"https://pubmed.ncbi.nlm.nih.gov/36321981/","study_design":null,"title":"Amyloid-Related Imaging Abnormalities: An Update","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/neuroimaging-correlates-of-cerebral-microbleeds-the-aric-study-29018129","doi":"10.1161/strokeaha.117.018336","journal":"Stroke","n_participants":null,"pmid":"29018129","source_url":"https://pubmed.ncbi.nlm.nih.gov/29018129/","study_design":null,"title":"Neuroimaging Correlates of Cerebral Microbleeds: The ARIC Study (Atherosclerosis Risk in Communities)","title_match":false,"year":2017},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/differences-in-brain-volume-hippocampal-volume-cerebrovascular-risk-19901172","doi":"10.1001/archneurol.2009.252","journal":"Archives of neurology","n_participants":153,"pmid":"19901172","source_url":"https://pubmed.ncbi.nlm.nih.gov/19901172/","study_design":"cross-sectional","title":"Differences in brain volume, hippocampal volume, cerebrovascular risk factors, and apolipoprotein E4 among mild cognitive impairment subtypes","title_match":true,"year":2009},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/association-of-amyloid-and-apolipoprotein-e-4-with-memory-decline-in-29356823","doi":"10.1001/jamaneurol.2017.4325","journal":"JAMA neurology","n_participants":1583,"pmid":"29356823","source_url":"https://pubmed.ncbi.nlm.nih.gov/29356823/","study_design":"longitudinal study","title":"Association of \u03b2-Amyloid and Apolipoprotein E \u03b54 With Memory Decline in Preclinical Alzheimer Disease","title_match":true,"year":2018},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/effect-of-intellectual-enrichment-on-ad-biomarker-trajectories-26911640","doi":"10.1212/wnl.0000000000002490","journal":"Neurology","n_participants":393,"pmid":"26911640","source_url":"https://pubmed.ncbi.nlm.nih.gov/26911640/","study_design":"longitudinal study","title":"Effect of intellectual enrichment on AD biomarker trajectories: Longitudinal imaging study","title_match":false,"year":2016},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/baseline-predictors-of-rates-of-hippocampal-atrophy-in-mild-cognitive-17923611","doi":"10.1212/01.wnl.0000277458.26846.96","journal":"Neurology","n_participants":323,"pmid":"17923611","source_url":"https://pubmed.ncbi.nlm.nih.gov/17923611/","study_design":null,"title":"Baseline predictors of rates of hippocampal atrophy in mild cognitive impairment","title_match":false,"year":2007},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/aphasic-variant-of-alzheimer-disease-clinical-anatomic-and-genetic-27566743","doi":"10.1212/wnl.0000000000003165","journal":"Neurology","n_participants":19,"pmid":"27566743","source_url":"https://pubmed.ncbi.nlm.nih.gov/27566743/","study_design":null,"title":"Aphasic variant of Alzheimer disease: Clinical, anatomic, and genetic features","title_match":false,"year":2016},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/alcohol-intake-in-relation-to-brain-magnetic-resonance-imaging-15447910","doi":"10.1093/ajcn/80.4.992","journal":"The American journal of clinical nutrition","n_participants":509,"pmid":"15447910","source_url":"https://pubmed.ncbi.nlm.nih.gov/15447910/","study_design":null,"title":"Alcohol intake in relation to brain magnetic resonance imaging findings in older persons without dementia","title_match":false,"year":2004},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/sex-differences-in-longitudinal-tau-pet-in-preclinical-alzheimer-40029638","doi":"10.1001/jamaneurol.2025.0013","journal":"JAMA neurology","n_participants":1376,"pmid":"40029638","source_url":"https://pubmed.ncbi.nlm.nih.gov/40029638/","study_design":"meta-analysis","title":"Sex Differences in Longitudinal Tau-PET in Preclinical Alzheimer Disease: A Meta-Analysis","title_match":false,"year":2025},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/i-apoe-i-4-white-matter-hyperintensities-and-cognition-in-alzheimer-31575706","doi":"10.1212/wnl.0000000000008377","journal":"Neurology","n_participants":167,"pmid":"31575706","source_url":"https://pubmed.ncbi.nlm.nih.gov/31575706/","study_design":"meta-analysis","title":"APOE \u03b54, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia","title_match":true,"year":2019},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/association-of-parental-dementia-with-cognitive-and-brain-mri-20007524","doi":"10.1212/wnl.0b013e3181c67833","journal":"Neurology","n_participants":717,"pmid":"20007524","source_url":"https://pubmed.ncbi.nlm.nih.gov/20007524/","study_design":null,"title":"Association of parental dementia with cognitive and brain MRI measures in middle-aged adults","title_match":false,"year":2009},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/microbleeds-do-not-affect-rate-of-cognitive-decline-in-alzheimer-22875093","doi":"10.1212/wnl.0b013e3182661f91","journal":"Neurology","n_participants":221,"pmid":"22875093","source_url":"https://pubmed.ncbi.nlm.nih.gov/22875093/","study_design":"cohort study","title":"Microbleeds do not affect rate of cognitive decline in Alzheimer disease","title_match":false,"year":2012},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/efficacy-and-safety-of-galantamine-in-patients-with-mild-to-moderate-11110737","doi":"10.1136/bmj.321.7274.1445","journal":"BMJ (Clinical research ed.)","n_participants":653,"pmid":"11110737","source_url":"https://pubmed.ncbi.nlm.nih.gov/11110737/","study_design":null,"title":"Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: multicentre randomised controlled trial. Galantamine International-1 Study Group","title_match":false,"year":2000},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/the-wisconsin-registry-for-alzheimer-s-prevention-a-review-of-29322089","doi":"10.1016/j.dadm.2017.11.007","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":1561,"pmid":"29322089","source_url":"https://pubmed.ncbi.nlm.nih.gov/29322089/","study_design":"cohort study","title":"The Wisconsin Registry for Alzheimer's Prevention: A review of findings and current directions","title_match":false,"year":2018},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/incidence-and-prevalence-of-dementia-in-the-cardiovascular-health-14728627","doi":"10.1111/j.1532-5415.2004.52058.x","journal":"Journal of the American Geriatrics Society","n_participants":227,"pmid":"14728627","source_url":"https://pubmed.ncbi.nlm.nih.gov/14728627/","study_design":"cohort study","title":"Incidence and prevalence of dementia in the Cardiovascular Health Study","title_match":false,"year":2004},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/clinical-imaging-and-pathological-heterogeneity-of-the-alzheimer-s-23302773","doi":"10.1186/alzrt155","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"23302773","source_url":"https://pubmed.ncbi.nlm.nih.gov/23302773/","study_design":null,"title":"Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome","title_match":false,"year":2013},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/rofecoxib-no-effect-on-alzheimer-s-disease-in-a-1-year-randomized-14718699","doi":"10.1212/wnl.62.1.66","journal":"Neurology","n_participants":692,"pmid":"14718699","source_url":"https://pubmed.ncbi.nlm.nih.gov/14718699/","study_design":null,"title":"Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study","title_match":false,"year":2004},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-especially-apolipoprotein-e4-increases-the-23100439","doi":"10.1523/jneurosci.1542-12.2012","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"23100439","source_url":"https://pubmed.ncbi.nlm.nih.gov/23100439/","study_design":null,"title":"Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid \u03b2 peptide","title_match":true,"year":2012},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/genes-associated-with-alzheimer-s-disease-an-overview-and-current-27274215","doi":"10.2147/cia.s105769","journal":"Clinical interventions in aging","n_participants":null,"pmid":"27274215","source_url":"https://pubmed.ncbi.nlm.nih.gov/27274215/","study_design":null,"title":"Genes associated with Alzheimer's disease: an overview and current status","title_match":false,"year":2016},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/florbetapir-f18-av-45-pet-to-assess-amyloid-burden-in-alzheimer-s-23375563","doi":"10.1016/j.jalz.2012.10.007","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":184,"pmid":"23375563","source_url":"https://pubmed.ncbi.nlm.nih.gov/23375563/","study_design":"clinical trial","title":"Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging","title_match":false,"year":2013},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/association-of-higher-cortical-amyloid-burden-with-loneliness-in-27806159","doi":"10.1001/jamapsychiatry.2016.2657","journal":"JAMA psychiatry","n_participants":25,"pmid":"27806159","source_url":"https://pubmed.ncbi.nlm.nih.gov/27806159/","study_design":"cross-sectional","title":"Association of Higher Cortical Amyloid Burden With Loneliness in Cognitively Normal Older Adults","title_match":false,"year":2016},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/cerebral-microbleeds-a-review-of-clinical-genetic-and-neuroimaging-24432010","doi":"10.3389/fneur.2013.00205","journal":"Frontiers in neurology","n_participants":null,"pmid":"24432010","source_url":"https://pubmed.ncbi.nlm.nih.gov/24432010/","study_design":null,"title":"Cerebral microbleeds: a review of clinical, genetic, and neuroimaging associations","title_match":false,"year":2014},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/pathological-combinations-in-neurodegenerative-disease-are-36864661","doi":"10.1093/brain/awad059","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"36864661","source_url":"https://pubmed.ncbi.nlm.nih.gov/36864661/","study_design":null,"title":"Pathological combinations in neurodegenerative disease are heterogeneous and disease-associated","title_match":false,"year":2023},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/i-apoe-i-genotype-regulates-pathology-and-disease-progression-in-32024799","doi":"10.1126/scitranslmed.aay3069","journal":"Science translational medicine","n_participants":null,"pmid":"32024799","source_url":"https://pubmed.ncbi.nlm.nih.gov/32024799/","study_design":null,"title":"APOE genotype regulates pathology and disease progression in synucleinopathy","title_match":false,"year":2020},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/double-blind-placebo-controlled-proof-of-concept-trial-of-bexarotene-26822146","doi":"10.1186/s13195-016-0173-2","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"26822146","source_url":"https://pubmed.ncbi.nlm.nih.gov/26822146/","study_design":null,"title":"Double-blind, placebo-controlled, proof-of-concept trial of bexarotene Xin moderate Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/pulse-wave-velocity-is-associated-with-amyloid-deposition-in-the-24132374","doi":"10.1212/01.wnl.0000435301.64776.37","journal":"Neurology","n_participants":91,"pmid":"24132374","source_url":"https://pubmed.ncbi.nlm.nih.gov/24132374/","study_design":null,"title":"Pulse wave velocity is associated with \u03b2-amyloid deposition in the brains of very elderly adults","title_match":false,"year":2013},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/use-of-anticholinergics-and-the-risk-of-cognitive-impairment-in-an-20625168","doi":"10.1212/wnl.0b013e3181e7f2ab","journal":"Neurology","n_participants":null,"pmid":"20625168","source_url":"https://pubmed.ncbi.nlm.nih.gov/20625168/","study_design":"longitudinal study","title":"Use of anticholinergics and the risk of cognitive impairment in an African American population","title_match":false,"year":2010},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/amyloid-is-linked-to-cognitive-decline-in-patients-with-parkinson-23243071","doi":"10.1212/wnl.0b013e31827b1a07","journal":"Neurology","n_participants":46,"pmid":"23243071","source_url":"https://pubmed.ncbi.nlm.nih.gov/23243071/","study_design":"cohort study","title":"Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia","title_match":false,"year":2013},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/cortical-alpha-synuclein-load-is-associated-with-amyloid-beta-plaque-18185940","doi":"10.1007/s00401-007-0336-0","journal":"Acta neuropathologica","n_participants":null,"pmid":"18185940","source_url":"https://pubmed.ncbi.nlm.nih.gov/18185940/","study_design":null,"title":"Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients","title_match":false,"year":2008},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/anemia-and-risk-of-dementia-in-older-adults-findings-from-the-health-23902706","doi":"10.1212/wnl.0b013e31829e701d","journal":"Neurology","n_participants":2552,"pmid":"23902706","source_url":"https://pubmed.ncbi.nlm.nih.gov/23902706/","study_design":null,"title":"Anemia and risk of dementia in older adults: findings from the Health ABC study","title_match":false,"year":2013},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/the-aric-pet-amyloid-imaging-study-brain-amyloid-differences-by-age-27371485","doi":"10.1212/wnl.0000000000002914","journal":"Neurology","n_participants":329,"pmid":"27371485","source_url":"https://pubmed.ncbi.nlm.nih.gov/27371485/","study_design":"longitudinal study","title":"The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE","title_match":false,"year":2016},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/shorter-telomeres-are-associated-with-mortality-in-those-with-apoe-16807921","doi":"10.1002/ana.20894","journal":"Annals of neurology","n_participants":257,"pmid":"16807921","source_url":"https://pubmed.ncbi.nlm.nih.gov/16807921/","study_design":"case-control study","title":"Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia","title_match":true,"year":2006},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/sex-differences-in-the-association-of-the-apolipoprotein-e-epsilon-4-20619505","doi":"10.1016/j.neurobiolaging.2010.05.017","journal":"Neurobiology of aging","n_participants":113,"pmid":"20619505","source_url":"https://pubmed.ncbi.nlm.nih.gov/20619505/","study_design":"longitudinal study","title":"Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline","title_match":false,"year":2012},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/olfaction-and-risk-of-dementia-in-a-biracial-cohort-of-older-adults-28039314","doi":"10.1212/wnl.0000000000003558","journal":"Neurology","n_participants":2428,"pmid":"28039314","source_url":"https://pubmed.ncbi.nlm.nih.gov/28039314/","study_design":null,"title":"Olfaction and risk of dementia in a biracial cohort of older adults","title_match":false,"year":2017},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/long-term-exposure-to-ambient-air-pollution-apoe-4-status-and-31926436","doi":"10.1016/j.envint.2019.105440","journal":"Environment international","n_participants":4821,"pmid":"31926436","source_url":"https://pubmed.ncbi.nlm.nih.gov/31926436/","study_design":null,"title":"Long-term exposure to ambient air pollution, APOE-\u03b54 status, and cognitive decline in a cohort of older adults in northern Manhattan","title_match":true,"year":2020},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/characterization-of-mexican-americans-with-mild-cognitive-impairment-22976076","doi":"10.3233/jad-2012-121420","journal":"Journal of Alzheimer's disease : JAD","n_participants":633,"pmid":"22976076","source_url":"https://pubmed.ncbi.nlm.nih.gov/22976076/","study_design":null,"title":"Characterization of Mexican Americans with mild cognitive impairment and Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/prevalence-and-correlates-of-mild-cognitive-impairment-among-diverse-31753701","doi":"10.1016/j.jalz.2019.08.202","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":6377,"pmid":"31753701","source_url":"https://pubmed.ncbi.nlm.nih.gov/31753701/","study_design":"cohort study","title":"Prevalence and correlates of mild cognitive impairment among diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging results","title_match":false,"year":2019},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/long-term-exposure-to-ambient-air-pollution-and-risk-of-dementia-33484961","doi":"10.1016/j.envint.2020.106376","journal":"Environment international","n_participants":541,"pmid":"33484961","source_url":"https://pubmed.ncbi.nlm.nih.gov/33484961/","study_design":null,"title":"Long-term exposure to ambient air pollution and risk of dementia: Results of the prospective Three-City Study","title_match":false,"year":2021},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/education-cognitive-test-scores-and-black-white-differences-in-16776783","doi":"10.1111/j.1532-5415.2006.00747.x","journal":"Journal of the American Geriatrics Society","n_participants":null,"pmid":"16776783","source_url":"https://pubmed.ncbi.nlm.nih.gov/16776783/","study_design":"longitudinal study","title":"Education, cognitive test scores, and black-white differences in dementia risk","title_match":false,"year":2006},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/the-effect-of-alcohol-and-tobacco-consumption-and-apolipoprotein-e-19750560","doi":"10.1002/gps.2372","journal":"International journal of geriatric psychiatry","n_participants":397,"pmid":"19750560","source_url":"https://pubmed.ncbi.nlm.nih.gov/19750560/","study_design":"cross-sectional","title":"The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/cognitive-resilience-to-apolipoprotein-e-4-contributing-factors-in-25599330","doi":"10.1001/jamaneurol.2014.3978","journal":"JAMA neurology","n_participants":2487,"pmid":"25599330","source_url":"https://pubmed.ncbi.nlm.nih.gov/25599330/","study_design":"prospective cohort","title":"Cognitive resilience to apolipoprotein E \u03b54: contributing factors in black and white older adults","title_match":true,"year":2015},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/total-and-cause-specific-mortality-in-the-cardiovascular-health-study-19723772","doi":"10.1093/gerona/glp127","journal":"The journals of gerontology. Series A, Biological sciences and medical sciences","n_participants":5888,"pmid":"19723772","source_url":"https://pubmed.ncbi.nlm.nih.gov/19723772/","study_design":"cohort study","title":"Total and cause-specific mortality in the cardiovascular health study","title_match":false,"year":2009},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/association-of-apoe-genotypes-and-chronic-traumatic-encephalopathy-35759276","doi":"10.1001/jamaneurol.2022.1634","journal":"JAMA neurology","n_participants":294,"pmid":"35759276","source_url":"https://pubmed.ncbi.nlm.nih.gov/35759276/","study_design":"cross-sectional","title":"Association of APOE Genotypes and Chronic Traumatic Encephalopathy","title_match":false,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/relationship-between-type-2-diabetes-mellitus-and-cognitive-change-in-26096383","doi":"10.1111/jgs.13441","journal":"Journal of the American Geriatrics Society","n_participants":1493,"pmid":"26096383","source_url":"https://pubmed.ncbi.nlm.nih.gov/26096383/","study_design":"cohort study","title":"Relationship Between Type 2 Diabetes Mellitus and Cognitive Change in a Multiethnic Elderly Cohort","title_match":false,"year":2015},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/epidemiology-of-dementia-in-nigeria-results-from-the-indianapolis-11054131","doi":"10.1046/j.1468-1331.2000.00124.x","journal":"European journal of neurology","n_participants":null,"pmid":"11054131","source_url":"https://pubmed.ncbi.nlm.nih.gov/11054131/","study_design":null,"title":"Epidemiology of dementia in Nigeria: results from the Indianapolis-Ibadan study","title_match":false,"year":2000},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/the-neuroinflammatory-biomarker-ykl-40-for-neurodegenerative-diseases-31195846","doi":"10.1080/14789450.2019.1628643","journal":"Expert review of proteomics","n_participants":null,"pmid":"31195846","source_url":"https://pubmed.ncbi.nlm.nih.gov/31195846/","study_design":null,"title":"The neuroinflammatory biomarker YKL-40 for neurodegenerative diseases: advances in development","title_match":false,"year":2019},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/type-2-diabetes-apoe-gene-and-the-risk-for-dementia-and-related-11916953","doi":"10.2337/diabetes.51.4.1256","journal":"Diabetes","n_participants":216,"pmid":"11916953","source_url":"https://pubmed.ncbi.nlm.nih.gov/11916953/","study_design":null,"title":"Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study","title_match":false,"year":2002},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/leisure-time-physical-activity-at-midlife-and-the-risk-of-dementia-16239176","doi":"10.1016/s1474-4422(05)70198-8","journal":"The Lancet. Neurology","n_participants":1449,"pmid":"16239176","source_url":"https://pubmed.ncbi.nlm.nih.gov/16239176/","study_design":null,"title":"Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease","title_match":false,"year":2005},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/apoe-in-alzheimer-s-disease-pathophysiology-and-therapeutic-strategies-36348357","doi":"10.1186/s13024-022-00574-4","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"36348357","source_url":"https://pubmed.ncbi.nlm.nih.gov/36348357/","study_design":null,"title":"ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies","title_match":false,"year":2022},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/epilepsy-and-cognitive-impairments-in-alzheimer-disease-19204149","doi":"10.1001/archneurol.2009.15","journal":"Archives of neurology","n_participants":null,"pmid":"19204149","source_url":"https://pubmed.ncbi.nlm.nih.gov/19204149/","study_design":null,"title":"Epilepsy and cognitive impairments in Alzheimer disease","title_match":false,"year":2009},{"alzhub_score":78,"alzhub_url":"https://alzhub.org/study/a-phase-iii-randomized-trial-of-gantenerumab-in-prodromal-alzheimer-s-29221491","doi":"10.1186/s13195-017-0318-y","journal":"Alzheimer's research & therapy","n_participants":3089,"pmid":"29221491","source_url":"https://pubmed.ncbi.nlm.nih.gov/29221491/","study_design":null,"title":"A phase III randomized trial of gantenerumab in prodromal Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/apoe4-homozygozity-represents-a-distinct-genetic-form-of-alzheimer-s-38710950","doi":"10.1038/s41591-024-02931-w","journal":"Nature medicine","n_participants":3297,"pmid":"38710950","source_url":"https://pubmed.ncbi.nlm.nih.gov/38710950/","study_design":null,"title":"APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/the-role-of-apoe-epsilon4-in-modulating-effects-of-other-risk-factors-10404910","doi":"10.1001/jama.282.1.40","journal":"JAMA","n_participants":5201,"pmid":"10404910","source_url":"https://pubmed.ncbi.nlm.nih.gov/10404910/","study_design":"cohort study","title":"The role of APOE epsilon4 in modulating effects of other risk factors for cognitive decline in elderly persons","title_match":true,"year":1999},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/subjective-cognitive-decline-and-rates-of-incident-alzheimer-s-30555032","doi":"10.1016/j.jalz.2018.10.003","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":2978,"pmid":"30555032","source_url":"https://pubmed.ncbi.nlm.nih.gov/30555032/","study_design":null,"title":"Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia","title_match":false,"year":2019},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/smoking-and-risk-of-dementia-and-alzheimer-s-disease-in-a-population-9652667","doi":"10.1016/s0140-6736(97)07541-7","journal":"Lancet (London, England)","n_participants":6870,"pmid":"9652667","source_url":"https://pubmed.ncbi.nlm.nih.gov/9652667/","study_design":"case-control study","title":"Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study","title_match":false,"year":1998},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/association-of-muscle-strength-with-the-risk-of-alzheimer-disease-and-19901164","doi":"10.1001/archneurol.2009.240","journal":"Archives of neurology","n_participants":138,"pmid":"19901164","source_url":"https://pubmed.ncbi.nlm.nih.gov/19901164/","study_design":"cohort study","title":"Association of muscle strength with the risk of Alzheimer disease and the rate of cognitive decline in community-dwelling older persons","title_match":false,"year":2009},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/risk-factors-for-mild-cognitive-impairment-in-the-cardiovascular-14568809","doi":"10.1001/archneur.60.10.1394","journal":"Archives of neurology","n_participants":927,"pmid":"14568809","source_url":"https://pubmed.ncbi.nlm.nih.gov/14568809/","study_design":"longitudinal study","title":"Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2","title_match":false,"year":2003},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/cognition-and-anatomy-in-three-variants-of-primary-progressive-aphasia-14991811","doi":"10.1002/ana.10825","journal":"Annals of neurology","n_participants":31,"pmid":"14991811","source_url":"https://pubmed.ncbi.nlm.nih.gov/14991811/","study_design":null,"title":"Cognition and anatomy in three variants of primary progressive aphasia","title_match":false,"year":2004},{"alzhub_score":77,"alzhub_url":"https://alzhub.org/study/a-cerebrospinal-fluid-synaptic-protein-biomarker-for-prediction-of-40164724","doi":"10.1038/s41591-025-03565-2","journal":"Nature medicine","n_participants":3397,"pmid":"40164724","source_url":"https://pubmed.ncbi.nlm.nih.gov/40164724/","study_design":"case-control study","title":"A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/neuropathologically-defined-subtypes-of-alzheimer-s-disease-differ-22968369","doi":"10.1007/s00401-012-1044-y","journal":"Acta neuropathologica","n_participants":18,"pmid":"22968369","source_url":"https://pubmed.ncbi.nlm.nih.gov/22968369/","study_design":null,"title":"Neuropathologically defined subtypes of Alzheimer's disease differ significantly from neurofibrillary tangle-predominant dementia","title_match":false,"year":2012},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/mri-predictors-of-amyloid-pathology-results-from-the-emif-ad-30261928","doi":"10.1186/s13195-018-0428-1","journal":"Alzheimer's research & therapy","n_participants":337,"pmid":"30261928","source_url":"https://pubmed.ncbi.nlm.nih.gov/30261928/","study_design":null,"title":"MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker Discovery study","title_match":false,"year":2018},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/apoe-4-carriers-share-immune-related-proteomic-changes-across-40665049","doi":"10.1038/s41591-025-03835-z","journal":"Nature medicine","n_participants":null,"pmid":"40665049","source_url":"https://pubmed.ncbi.nlm.nih.gov/40665049/","study_design":null,"title":"APOE \u03b54 carriers share immune-related proteomic changes across neurodegenerative diseases","title_match":true,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/gps-driving-a-digital-biomarker-for-preclinical-alzheimer-disease-34127064","doi":"10.1186/s13195-021-00852-1","journal":"Alzheimer's research & therapy","n_participants":64,"pmid":"34127064","source_url":"https://pubmed.ncbi.nlm.nih.gov/34127064/","study_design":null,"title":"GPS driving: a digital biomarker for preclinical Alzheimer disease","title_match":false,"year":2021},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/sex-specific-cross-tissue-meta-analysis-identifies-immune-34658838","doi":"10.3389/fnagi.2021.735611","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"34658838","source_url":"https://pubmed.ncbi.nlm.nih.gov/34658838/","study_design":"meta-analysis","title":"Sex-Specific Cross Tissue Meta-Analysis Identifies Immune Dysregulation in Women With Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/association-between-hearing-loss-and-development-of-dementia-using-36410368","doi":"10.1016/s2666-7568(22)00241-0","journal":"The lancet. Healthy longevity","n_participants":null,"pmid":"36410368","source_url":"https://pubmed.ncbi.nlm.nih.gov/36410368/","study_design":null,"title":"Association between hearing loss and development of dementia using formal behavioural audiometric testing within the Mayo Clinic Study of Aging (MCSA): a prospective population-based study","title_match":false,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/primary-progressive-aphasia-and-the-language-network-the-2013-h-23897873","doi":"10.1212/wnl.0b013e31829d87df","journal":"Neurology","n_participants":null,"pmid":"23897873","source_url":"https://pubmed.ncbi.nlm.nih.gov/23897873/","study_design":null,"title":"Primary progressive aphasia and the language network: the 2013 H. Houston Merritt Lecture","title_match":false,"year":2013},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/neuropsychological-performance-in-advanced-age-influences-of-18609337","doi":"10.1080/13854040801894730","journal":"The Clinical neuropsychologist","n_participants":507,"pmid":"18609337","source_url":"https://pubmed.ncbi.nlm.nih.gov/18609337/","study_design":null,"title":"Neuropsychological performance in advanced age: influences of demographic factors and Apolipoprotein E: findings from the Cache County Memory Study","title_match":false,"year":2009},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/prediction-models-for-dementia-and-neuropathology-in-the-oldest-old-30670070","doi":"10.1186/s13195-018-0450-3","journal":"Alzheimer's research & therapy","n_participants":245,"pmid":"30670070","source_url":"https://pubmed.ncbi.nlm.nih.gov/30670070/","study_design":null,"title":"Prediction models for dementia and neuropathology in the oldest old: the Vantaa 85+ cohort study","title_match":false,"year":2019},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/csf-complement-3-and-factor-h-are-staging-biomarkers-in-alzheimer-s-26887322","doi":"10.1186/s40478-016-0277-8","journal":"Acta neuropathologica communications","n_participants":230,"pmid":"26887322","source_url":"https://pubmed.ncbi.nlm.nih.gov/26887322/","study_design":null,"title":"CSF complement 3 and factor H are staging biomarkers in Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/the-vallecas-project-a-cohort-to-identify-early-markers-and-26483681","doi":"10.3389/fnagi.2015.00181","journal":"Frontiers in aging neuroscience","n_participants":1169,"pmid":"26483681","source_url":"https://pubmed.ncbi.nlm.nih.gov/26483681/","study_design":"cohort study","title":"The Vallecas Project: A Cohort to Identify Early Markers and Mechanisms of Alzheimer's Disease","title_match":false,"year":2015},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/independent-replication-of-advanced-brain-age-in-mild-cognitive-35974140","doi":"10.1038/s41380-022-01728-y","journal":"Molecular psychiatry","n_participants":757,"pmid":"35974140","source_url":"https://pubmed.ncbi.nlm.nih.gov/35974140/","study_design":null,"title":"Independent replication of advanced brain age in mild cognitive impairment and dementia: detection of future cognitive dysfunction","title_match":false,"year":2022},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-controls-cerebrovascular-integrity-via-cyclophilin-a-22622580","doi":"10.1038/nature11087","journal":"Nature","n_participants":null,"pmid":"22622580","source_url":"https://pubmed.ncbi.nlm.nih.gov/22622580/","study_design":null,"title":"Apolipoprotein E controls cerebrovascular integrity via cyclophilin A","title_match":false,"year":2012},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/patterns-of-brain-activation-in-people-at-risk-for-alzheimer-s-disease-10944562","doi":"10.1056/nejm200008173430701","journal":"The New England journal of medicine","n_participants":30,"pmid":"10944562","source_url":"https://pubmed.ncbi.nlm.nih.gov/10944562/","study_design":null,"title":"Patterns of brain activation in people at risk for Alzheimer's disease","title_match":false,"year":2000},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/risk-factors-for-alzheimer-s-disease-a-prospective-analysis-from-the-12196314","doi":"10.1093/aje/kwf074","journal":"American journal of epidemiology","n_participants":194,"pmid":"12196314","source_url":"https://pubmed.ncbi.nlm.nih.gov/12196314/","study_design":null,"title":"Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging","title_match":false,"year":2002},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-and-plasma-insulin-levels-in-alzheimer-s-disease-9443474","doi":"10.1212/wnl.50.1.164","journal":"Neurology","n_participants":25,"pmid":"9443474","source_url":"https://pubmed.ncbi.nlm.nih.gov/9443474/","study_design":null,"title":"Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype","title_match":false,"year":1998},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/predictors-of-cognitive-decline-and-mortality-of-aged-people-over-a-15031312","doi":"10.1093/gerona/59.3.m268","journal":"The journals of gerontology. Series A, Biological sciences and medical sciences","n_participants":650,"pmid":"15031312","source_url":"https://pubmed.ncbi.nlm.nih.gov/15031312/","study_design":null,"title":"Predictors of cognitive decline and mortality of aged people over a 10-year period","title_match":false,"year":2004},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/alzheimer-and-frontotemporal-pathology-in-subsets-of-primary-18412267","doi":"10.1002/ana.21388","journal":"Annals of neurology","n_participants":null,"pmid":"18412267","source_url":"https://pubmed.ncbi.nlm.nih.gov/18412267/","study_design":null,"title":"Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia","title_match":false,"year":2008},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/apoe4-exacerbates-synapse-loss-and-neurodegeneration-in-alzheimer-s-33139712","doi":"10.1038/s41467-020-19264-0","journal":"Nature communications","n_participants":null,"pmid":"33139712","source_url":"https://pubmed.ncbi.nlm.nih.gov/33139712/","study_design":null,"title":"APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids","title_match":true,"year":2020},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/cholesterol-as-a-risk-factor-for-dementia-and-cognitive-decline-a-18448847","doi":"10.1097/jgp.0b013e31816b72d4","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":14331,"pmid":"18448847","source_url":"https://pubmed.ncbi.nlm.nih.gov/18448847/","study_design":"systematic review","title":"Cholesterol as a risk factor for dementia and cognitive decline: a systematic review of prospective studies with meta-analysis","title_match":false,"year":2008},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/synuclein-in-the-pathophysiology-of-alzheimer-s-disease-31186026","doi":"10.1186/s13024-019-0320-x","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"31186026","source_url":"https://pubmed.ncbi.nlm.nih.gov/31186026/","study_design":null,"title":"\u03b1-synuclein in the pathophysiology of Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/apoe-epsilon4-count-predicts-age-when-prevalence-of-ad-increases-then-10430421","doi":"10.1212/wnl.53.2.321","journal":"Neurology","n_participants":null,"pmid":"10430421","source_url":"https://pubmed.ncbi.nlm.nih.gov/10430421/","study_design":null,"title":"APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study","title_match":true,"year":1999},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/apoe-cascade-hypothesis-in-the-pathogenesis-of-alzheimer-s-disease-35298921","doi":"10.1016/j.neuron.2022.03.004","journal":"Neuron","n_participants":null,"pmid":"35298921","source_url":"https://pubmed.ncbi.nlm.nih.gov/35298921/","study_design":null,"title":"ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias","title_match":false,"year":2022},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/long-term-metformin-usage-and-cognitive-function-among-older-adults-24577463","doi":"10.3233/jad-131901","journal":"Journal of Alzheimer's disease : JAD","n_participants":204,"pmid":"24577463","source_url":"https://pubmed.ncbi.nlm.nih.gov/24577463/","study_design":"cross-sectional","title":"Long-term metformin usage and cognitive function among older adults with diabetes","title_match":false,"year":2014},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-epsilon4-association-with-dementia-in-a-population-8618665","doi":"10.1212/wnl.46.3.673","journal":"Neurology","n_participants":21,"pmid":"8618665","source_url":"https://pubmed.ncbi.nlm.nih.gov/8618665/","study_design":null,"title":"Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study","title_match":true,"year":1996},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/down-syndrome-alzheimer-s-disease-and-seizures-15862185","doi":"10.1016/j.braindev.2004.07.008","journal":"Brain & development","n_participants":null,"pmid":"15862185","source_url":"https://pubmed.ncbi.nlm.nih.gov/15862185/","study_design":null,"title":"Down syndrome, Alzheimer's disease and seizures","title_match":false,"year":2005},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/are-hereditary-hemochromatosis-mutations-involved-in-alzheimer-disease-10861683","doi":"10.1002/1096-8628(20000703)93:1<58::aid-ajmg10>3.0.co;2-l","journal":"American journal of medical genetics","n_participants":26,"pmid":"10861683","source_url":"https://pubmed.ncbi.nlm.nih.gov/10861683/","study_design":null,"title":"Are hereditary hemochromatosis mutations involved in Alzheimer disease?","title_match":false,"year":2000},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/increased-amyloid-beta-protein-levels-in-children-and-adolescents-17275850","doi":"10.1016/j.jns.2006.12.010","journal":"Journal of the neurological sciences","n_participants":35,"pmid":"17275850","source_url":"https://pubmed.ncbi.nlm.nih.gov/17275850/","study_design":null,"title":"Increased amyloid beta protein levels in children and adolescents with Down syndrome","title_match":false,"year":2007},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/microglial-activation-induced-by-factor-s-contained-in-sera-from-9822164","doi":"10.1002/(sici)1097-4547(19981115)54:4<539::aid-jnr11>3.0.co;2-q","journal":"Journal of neuroscience research","n_participants":null,"pmid":"9822164","source_url":"https://pubmed.ncbi.nlm.nih.gov/9822164/","study_design":null,"title":"Microglial activation induced by factor(s) contained in sera from Alzheimer-related ApoE genotypes","title_match":false,"year":1998},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/differential-associations-of-apolipoprotein-e-4-genotype-with-32986108","doi":"10.1001/jamanetworkopen.2020.18221","journal":"JAMA network open","n_participants":240,"pmid":"32986108","source_url":"https://pubmed.ncbi.nlm.nih.gov/32986108/","study_design":"cross-sectional","title":"Differential Associations of Apolipoprotein E \u03b54 Genotype With Attentional Abilities Across the Life Span of Individuals With Down Syndrome","title_match":true,"year":2020},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/cross-sectional-fdg-in-down-syndrome-and-autosomal-dominant-alzheimer-40977577","doi":"10.1002/ana.78002","journal":"Annals of neurology","n_participants":76,"pmid":"40977577","source_url":"https://pubmed.ncbi.nlm.nih.gov/40977577/","study_design":"cross-sectional","title":"Cross-Sectional FDG in Down Syndrome and Autosomal Dominant Alzheimer's Disease","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/neurodegenerative-disease-concomitant-proteinopathies-are-prevalent-29878075","doi":"10.1093/brain/awy146","journal":"Brain : a journal of neurology","n_participants":247,"pmid":"29878075","source_url":"https://pubmed.ncbi.nlm.nih.gov/29878075/","study_design":null,"title":"Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated","title_match":true,"year":2018},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/tdp-43-pathology-in-alzheimer-s-disease-34930382","doi":"10.1186/s13024-021-00503-x","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"34930382","source_url":"https://pubmed.ncbi.nlm.nih.gov/34930382/","study_design":null,"title":"TDP-43 Pathology in Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-with-amygdala-lewy-bodies-a-distinct-form-of-alpha-16825955","doi":"10.1097/01.jnen.0000225908.90052.07","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"16825955","source_url":"https://pubmed.ncbi.nlm.nih.gov/16825955/","study_design":null,"title":"Alzheimer disease with amygdala Lewy bodies: a distinct form of alpha-synucleinopathy","title_match":false,"year":2006},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/new-insights-into-the-genetic-etiology-of-alzheimer-s-disease-and-35379992","doi":"10.1038/s41588-022-01024-z","journal":"Nature genetics","n_participants":null,"pmid":"35379992","source_url":"https://pubmed.ncbi.nlm.nih.gov/35379992/","study_design":null,"title":"New insights into the genetic etiology of Alzheimer's disease and related dementias","title_match":false,"year":2022},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/vitamin-e-and-donepezil-for-the-treatment-of-mild-cognitive-impairment-15829527","doi":"10.1056/nejmoa050151","journal":"The New England journal of medicine","n_participants":769,"pmid":"15829527","source_url":"https://pubmed.ncbi.nlm.nih.gov/15829527/","study_design":null,"title":"Vitamin E and donepezil for the treatment of mild cognitive impairment","title_match":false,"year":2005},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/age-apoe-and-sex-triad-of-risk-of-alzheimer-s-disease-26969397","doi":"10.1016/j.jsbmb.2016.03.012","journal":"The Journal of steroid biochemistry and molecular biology","n_participants":null,"pmid":"26969397","source_url":"https://pubmed.ncbi.nlm.nih.gov/26969397/","study_design":null,"title":"Age, APOE and sex: Triad of risk of Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/marked-gender-differences-in-progression-of-mild-cognitive-impairment-26451386","doi":"10.1016/j.trci.2015.07.001","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":null,"pmid":"26451386","source_url":"https://pubmed.ncbi.nlm.nih.gov/26451386/","study_design":"longitudinal study","title":"Marked gender differences in progression of mild cognitive impairment over 8 years","title_match":false,"year":2015},{"alzhub_score":75,"alzhub_url":"https://alzhub.org/study/risk-factors-for-predicting-progression-from-mild-cognitive-26001840","doi":"10.1136/jnnp-2014-310095","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":14821,"pmid":"26001840","source_url":"https://pubmed.ncbi.nlm.nih.gov/26001840/","study_design":"meta-analysis","title":"Risk factors for predicting progression from mild cognitive impairment to Alzheimer's disease: a systematic review and meta-analysis of cohort studies","title_match":false,"year":2016},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/independent-information-from-cerebrospinal-fluid-amyloid-and-25541191","doi":"10.1093/brain/awu367","journal":"Brain : a journal of neurology","n_participants":769,"pmid":"25541191","source_url":"https://pubmed.ncbi.nlm.nih.gov/25541191/","study_design":null,"title":"Independent information from cerebrospinal fluid amyloid-\u03b2 and florbetapir imaging in Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/risk-profiles-for-mild-cognitive-impairment-and-progression-to-18450788","doi":"10.1136/jnnp.2007.136903","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":6892,"pmid":"18450788","source_url":"https://pubmed.ncbi.nlm.nih.gov/18450788/","study_design":null,"title":"Risk profiles for mild cognitive impairment and progression to dementia are gender specific","title_match":false,"year":2008},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/sex-and-age-differences-in-atrophic-rates-an-adni-study-with-n-1368-20620666","doi":"10.1016/j.neurobiolaging.2010.04.033","journal":"Neurobiology of aging","n_participants":363,"pmid":"20620666","source_url":"https://pubmed.ncbi.nlm.nih.gov/20620666/","study_design":"longitudinal study","title":"Sex and age differences in atrophic rates: an ADNI study with n=1368 MRI scans","title_match":false,"year":2010},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/concerted-changes-in-transcripts-in-the-prefrontal-cortex-precede-20889584","doi":"10.1093/brain/awq258","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"20889584","source_url":"https://pubmed.ncbi.nlm.nih.gov/20889584/","study_design":null,"title":"Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/24s-hydroxycholesterol-in-cerebrospinal-fluid-is-elevated-in-early-11755458","doi":"10.1016/s0022-3956(01)00050-4","journal":"Journal of psychiatric research","n_participants":32,"pmid":"11755458","source_url":"https://pubmed.ncbi.nlm.nih.gov/11755458/","study_design":null,"title":"24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia","title_match":false,"year":2002},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/association-of-elevated-amyloid-levels-with-cognition-and-biomarkers-26595683","doi":"10.1001/jamaneurol.2015.3098","journal":"JAMA neurology","n_participants":286,"pmid":"26595683","source_url":"https://pubmed.ncbi.nlm.nih.gov/26595683/","study_design":"longitudinal study","title":"Association of Elevated Amyloid Levels With Cognition and Biomarkers in Cognitively Normal People From the Community","title_match":false,"year":2016},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/colocalization-of-cerebral-iron-with-amyloid-beta-in-mild-cognitive-27748454","doi":"10.1038/srep35514","journal":"Scientific reports","n_participants":null,"pmid":"27748454","source_url":"https://pubmed.ncbi.nlm.nih.gov/27748454/","study_design":null,"title":"Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment","title_match":false,"year":2016},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/csf-tau-protein-phosphorylated-at-threonine-231-correlates-with-12196665","doi":"10.1212/wnl.59.4.627","journal":"Neurology","n_participants":77,"pmid":"12196665","source_url":"https://pubmed.ncbi.nlm.nih.gov/12196665/","study_design":"longitudinal study","title":"CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects","title_match":false,"year":2002},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/prevalence-of-mild-cognitive-impairment-in-an-urban-community-in-24613707","doi":"10.1016/j.jalz.2013.11.002","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"24613707","source_url":"https://pubmed.ncbi.nlm.nih.gov/24613707/","study_design":null,"title":"Prevalence of mild cognitive impairment in an urban community in China: a cross-sectional analysis of the Shanghai Aging Study","title_match":false,"year":2015},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/can-ketones-help-rescue-brain-fuel-supply-in-later-life-implications-27458340","doi":"10.3389/fnmol.2016.00053","journal":"Frontiers in molecular neuroscience","n_participants":null,"pmid":"27458340","source_url":"https://pubmed.ncbi.nlm.nih.gov/27458340/","study_design":null,"title":"Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer's Disease","title_match":false,"year":2016},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/a-ketogenic-drink-improves-cognition-in-mild-cognitive-impairment-33103819","doi":"10.1002/alz.12206","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":39,"pmid":"33103819","source_url":"https://pubmed.ncbi.nlm.nih.gov/33103819/","study_design":null,"title":"A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6-month RCT","title_match":false,"year":2021},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/impact-of-ssri-therapy-on-risk-of-conversion-from-mild-cognitive-29179578","doi":"10.1176/appi.ajp.2017.17040404","journal":"The American journal of psychiatry","n_participants":null,"pmid":"29179578","source_url":"https://pubmed.ncbi.nlm.nih.gov/29179578/","study_design":"longitudinal study","title":"Impact of SSRI Therapy on Risk of Conversion From Mild Cognitive Impairment to Alzheimer's Dementia in Individuals With Previous Depression","title_match":false,"year":2018},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/late-life-depression-as-a-risk-factor-for-mild-cognitive-impairment-22543846","doi":"10.3233/jad-2012-111922","journal":"Journal of Alzheimer's disease : JAD","n_participants":5607,"pmid":"22543846","source_url":"https://pubmed.ncbi.nlm.nih.gov/22543846/","study_design":null,"title":"Late-life depression as a risk factor for mild cognitive impairment or Alzheimer's disease in 30 US Alzheimer's disease centers","title_match":false,"year":2012},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/a-european-multicentre-pet-study-of-fibrillar-amyloid-in-alzheimer-s-22961445","doi":"10.1007/s00259-012-2237-2","journal":"European journal of nuclear medicine and molecular imaging","n_participants":97,"pmid":"22961445","source_url":"https://pubmed.ncbi.nlm.nih.gov/22961445/","study_design":null,"title":"A European multicentre PET study of fibrillar amyloid in Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/cognitive-reserve-and-clinical-progression-in-alzheimer-disease-a-31266904","doi":"10.1212/wnl.0000000000007821","journal":"Neurology","n_participants":175,"pmid":"31266904","source_url":"https://pubmed.ncbi.nlm.nih.gov/31266904/","study_design":"longitudinal study","title":"Cognitive reserve and clinical progression in Alzheimer disease: A paradoxical relationship","title_match":false,"year":2019},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/the-accumulation-rate-of-tau-aggregates-is-higher-in-females-and-33439987","doi":"10.1093/brain/awaa327","journal":"Brain : a journal of neurology","n_participants":157,"pmid":"33439987","source_url":"https://pubmed.ncbi.nlm.nih.gov/33439987/","study_design":"cohort study","title":"The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects","title_match":false,"year":2020},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/predictive-value-of-apoe-4-allele-for-progression-from-mci-to-ad-type-21493755","doi":"10.1136/jnnp.2010.231555","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":35,"pmid":"21493755","source_url":"https://pubmed.ncbi.nlm.nih.gov/21493755/","study_design":"meta-analysis","title":"Predictive value of APOE-\u03b54 allele for progression from MCI to AD-type dementia: a meta-analysis","title_match":true,"year":2011},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/the-dynamics-of-alzheimer-s-disease-biomarkers-in-the-alzheimer-s-20538373","doi":"10.1016/j.neurobiolaging.2010.04.024","journal":"Neurobiology of aging","n_participants":null,"pmid":"20538373","source_url":"https://pubmed.ncbi.nlm.nih.gov/20538373/","study_design":null,"title":"The dynamics of Alzheimer's disease biomarkers in the Alzheimer's Disease Neuroimaging Initiative cohort","title_match":false,"year":2010},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/peripheral-oxidative-damage-in-mild-cognitive-impairment-and-mild-18780972","doi":"10.3233/jad-2008-15110","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"18780972","source_url":"https://pubmed.ncbi.nlm.nih.gov/18780972/","study_design":null,"title":"Peripheral oxidative damage in mild cognitive impairment and mild Alzheimer's disease","title_match":false,"year":2008},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/rapid-progression-from-mild-cognitive-impairment-to-alzheimer-s-19420940","doi":"10.1159/000216841","journal":"Dementia and geriatric cognitive disorders","n_participants":58,"pmid":"19420940","source_url":"https://pubmed.ncbi.nlm.nih.gov/19420940/","study_design":null,"title":"Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype","title_match":true,"year":2009},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/structural-covariance-of-the-default-network-in-healthy-and-24048852","doi":"10.1523/jneurosci.2261-13.2013","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":414,"pmid":"24048852","source_url":"https://pubmed.ncbi.nlm.nih.gov/24048852/","study_design":"cross-sectional","title":"Structural covariance of the default network in healthy and pathological aging","title_match":false,"year":2013},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/integration-and-relative-value-of-biomarkers-for-prediction-of-mci-to-24371799","doi":"10.1016/j.nicl.2013.11.010","journal":"NeuroImage. Clinical","n_participants":null,"pmid":"24371799","source_url":"https://pubmed.ncbi.nlm.nih.gov/24371799/","study_design":null,"title":"Integration and relative value of biomarkers for prediction of MCI to AD progression: spatial patterns of brain atrophy, cognitive scores, APOE genotype and CSF biomarkers","title_match":false,"year":2014},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/gender-differences-in-risk-factors-for-transition-from-mild-cognitive-26343475","doi":"10.1016/j.comppsych.2015.07.002","journal":"Comprehensive psychiatry","n_participants":294,"pmid":"26343475","source_url":"https://pubmed.ncbi.nlm.nih.gov/26343475/","study_design":"cohort study","title":"Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease: A CREDOS study","title_match":false,"year":2015},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/predicting-the-risk-of-mild-cognitive-impairment-in-the-mayo-clinic-25788555","doi":"10.1212/wnl.0000000000001437","journal":"Neurology","n_participants":null,"pmid":"25788555","source_url":"https://pubmed.ncbi.nlm.nih.gov/25788555/","study_design":"cohort study","title":"Predicting the risk of mild cognitive impairment in the Mayo Clinic Study of Aging","title_match":false,"year":2015},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/genetics-of-alzheimer-disease-21045163","doi":"10.1177/0891988710383571","journal":"Journal of geriatric psychiatry and neurology","n_participants":null,"pmid":"21045163","source_url":"https://pubmed.ncbi.nlm.nih.gov/21045163/","study_design":null,"title":"Genetics of Alzheimer disease","title_match":false,"year":2010},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/structure-dependent-impairment-of-intracellular-apolipoprotein-e4-21454574","doi":"10.1074/jbc.m110.217380","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"21454574","source_url":"https://pubmed.ncbi.nlm.nih.gov/21454574/","study_design":null,"title":"Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors","title_match":true,"year":2011},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/variant-of-trem2-associated-with-the-risk-of-alzheimer-s-disease-23150908","doi":"10.1056/nejmoa1211103","journal":"The New England journal of medicine","n_participants":null,"pmid":"23150908","source_url":"https://pubmed.ncbi.nlm.nih.gov/23150908/","study_design":"case-control study","title":"Variant of TREM2 associated with the risk of Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/increased-cerebrospinal-fluid-soluble-trem2-concentration-in-26754172","doi":"10.1186/s13024-016-0071-x","journal":"Molecular neurodegeneration","n_participants":37,"pmid":"26754172","source_url":"https://pubmed.ncbi.nlm.nih.gov/26754172/","study_design":null,"title":"Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/alzheimer-s-risk-factors-age-apoe-genotype-and-sex-drive-distinct-32199103","doi":"10.1016/j.neuron.2020.02.034","journal":"Neuron","n_participants":null,"pmid":"32199103","source_url":"https://pubmed.ncbi.nlm.nih.gov/32199103/","study_design":null,"title":"Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways","title_match":false,"year":2020},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-metabolism-and-functions-in-brain-and-its-role-in-27922847","doi":"10.1097/mol.0000000000000383","journal":"Current opinion in lipidology","n_participants":null,"pmid":"27922847","source_url":"https://pubmed.ncbi.nlm.nih.gov/27922847/","study_design":null,"title":"Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/investigating-the-role-of-rare-heterozygous-trem2-variants-in-24119542","doi":"10.1016/j.neurobiolaging.2013.09.009","journal":"Neurobiology of aging","n_participants":null,"pmid":"24119542","source_url":"https://pubmed.ncbi.nlm.nih.gov/24119542/","study_design":"meta-analysis","title":"Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia","title_match":false,"year":2014},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-genetics-of-alzheimer-s-disease-24729694","doi":"10.2147/cia.s51571","journal":"Clinical interventions in aging","n_participants":null,"pmid":"24729694","source_url":"https://pubmed.ncbi.nlm.nih.gov/24729694/","study_design":null,"title":"The genetics of Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/phospholipids-of-apoe-lipoproteins-activate-microglia-in-an-isoform-34099706","doi":"10.1038/s41467-021-23762-0","journal":"Nature communications","n_participants":null,"pmid":"34099706","source_url":"https://pubmed.ncbi.nlm.nih.gov/34099706/","study_design":null,"title":"Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/trem2-independent-microgliosis-promotes-tau-mediated-36368315","doi":"10.1016/j.neuron.2022.10.022","journal":"Neuron","n_participants":null,"pmid":"36368315","source_url":"https://pubmed.ncbi.nlm.nih.gov/36368315/","study_design":null,"title":"TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4","title_match":true,"year":2023},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/trem2-in-alzheimer-s-disease-23407992","doi":"10.1007/s12035-013-8424-8","journal":"Molecular neurobiology","n_participants":null,"pmid":"23407992","source_url":"https://pubmed.ncbi.nlm.nih.gov/23407992/","study_design":null,"title":"TREM2 in Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/disease-associated-mutations-of-trem2-alter-the-processing-of-n-25615530","doi":"10.1111/tra.12264","journal":"Traffic (Copenhagen, Denmark)","n_participants":null,"pmid":"25615530","source_url":"https://pubmed.ncbi.nlm.nih.gov/25615530/","study_design":null,"title":"Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus","title_match":false,"year":2015},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/could-alzheimer-s-disease-originate-in-the-periphery-and-if-so-how-so-29705945","doi":"10.1007/s12035-018-1092-y","journal":"Molecular neurobiology","n_participants":null,"pmid":"29705945","source_url":"https://pubmed.ncbi.nlm.nih.gov/29705945/","study_design":null,"title":"Could Alzheimer's Disease Originate in the Periphery and If So How So?","title_match":false,"year":2019},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/higher-csf-strem2-attenuates-apoe4-related-risk-for-cognitive-decline-33032659","doi":"10.1186/s13024-020-00407-2","journal":"Molecular neurodegeneration","n_participants":221,"pmid":"33032659","source_url":"https://pubmed.ncbi.nlm.nih.gov/33032659/","study_design":"longitudinal study","title":"Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration","title_match":true,"year":2020},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/trem2-deficiency-differentially-affects-phenotype-and-transcriptome-32703241","doi":"10.1186/s13024-020-00394-4","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"32703241","source_url":"https://pubmed.ncbi.nlm.nih.gov/32703241/","study_design":null,"title":"Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice","title_match":true,"year":2020},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-linked-risk-alleles-elevate-microglial-cgas-39353433","doi":"10.1016/j.neuron.2024.09.006","journal":"Neuron","n_participants":null,"pmid":"39353433","source_url":"https://pubmed.ncbi.nlm.nih.gov/39353433/","study_design":null,"title":"Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model","title_match":false,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/uncovering-disease-mechanisms-in-a-novel-mouse-model-expressing-34707490","doi":"10.3389/fnagi.2021.735524","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"34707490","source_url":"https://pubmed.ncbi.nlm.nih.gov/34707490/","study_design":"cross-sectional","title":"Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOE\u03b54 and Trem2*R47H","title_match":true,"year":2021},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/gene-co-expression-networks-identify-trem2-and-tyrobp-as-major-hubs-28502803","doi":"10.1016/j.nbd.2017.05.006","journal":"Neurobiology of disease","n_participants":null,"pmid":"28502803","source_url":"https://pubmed.ncbi.nlm.nih.gov/28502803/","study_design":null,"title":"Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury","title_match":false,"year":2017},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/age-and-the-association-between-apolipoprotein-e-genotype-and-32817639","doi":"10.1371/journal.pmed.1003289","journal":"PLoS medicine","n_participants":1593,"pmid":"32817639","source_url":"https://pubmed.ncbi.nlm.nih.gov/32817639/","study_design":"cohort study","title":"Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study","title_match":false,"year":2020},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/impact-of-c-reactive-protein-on-cognition-and-alzheimer-disease-34266923","doi":"10.1212/wnl.0000000000012512","journal":"Neurology","n_participants":null,"pmid":"34266923","source_url":"https://pubmed.ncbi.nlm.nih.gov/34266923/","study_design":null,"title":"Impact of C-Reactive Protein on Cognition and Alzheimer Disease Biomarkers in Homozygous APOE \u025b4 Carriers","title_match":false,"year":2021},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/cardiorespiratory-fitness-alters-the-influence-of-a-polygenic-risk-28341646","doi":"10.1212/wnl.0000000000003862","journal":"Neurology","n_participants":null,"pmid":"28341646","source_url":"https://pubmed.ncbi.nlm.nih.gov/28341646/","study_design":"cross-sectional","title":"Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD","title_match":false,"year":2017},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/visit-to-visit-blood-pressure-variability-and-csf-alzheimer-disease-35418462","doi":"10.1212/wnl.0000000000200302","journal":"Neurology","n_participants":null,"pmid":"35418462","source_url":"https://pubmed.ncbi.nlm.nih.gov/35418462/","study_design":"cohort study","title":"Visit-to-Visit Blood Pressure Variability and CSF Alzheimer Disease Biomarkers in Cognitively Unimpaired and Mildly Impaired Older Adults","title_match":false,"year":2022},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/csf-alzheimer-disease-biomarkers-time-varying-relationships-with-mci-36216518","doi":"10.1212/wnl.0000000000200953","journal":"Neurology","n_participants":273,"pmid":"36216518","source_url":"https://pubmed.ncbi.nlm.nih.gov/36216518/","study_design":"longitudinal study","title":"CSF Alzheimer Disease Biomarkers: Time-Varying Relationships With MCI Symptom Onset and Associations With Age, Sex, and ApoE4","title_match":true,"year":2022},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/leveraging-large-multi-center-cohorts-of-alzheimer-disease-35617280","doi":"10.1371/journal.pone.0267298","journal":"PloS one","n_participants":5541,"pmid":"35617280","source_url":"https://pubmed.ncbi.nlm.nih.gov/35617280/","study_design":null,"title":"Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk","title_match":false,"year":2022},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/interactions-between-apolipoprotein-e-sex-and-amyloid-beta-on-36041266","doi":"10.1016/j.ebiom.2022.104241","journal":"EBioMedicine","n_participants":null,"pmid":"36041266","source_url":"https://pubmed.ncbi.nlm.nih.gov/36041266/","study_design":"cohort study","title":"Interactions between apolipoprotein E, sex, and amyloid-beta on cerebrospinal fluid p-tau levels in the European prevention of Alzheimer's dementia longitudinal cohort study (EPAD LCS)","title_match":false,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/csf-beta-amyloid-1-42-and-tau-in-tunisian-patients-with-alzheimer-s-18555606","doi":"10.1016/j.neulet.2008.05.076","journal":"Neuroscience letters","n_participants":73,"pmid":"18555606","source_url":"https://pubmed.ncbi.nlm.nih.gov/18555606/","study_design":null,"title":"CSF beta-amyloid 1-42 and tau in Tunisian patients with Alzheimer's disease: the effect of APOE epsilon4 allele","title_match":true,"year":2008},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/association-of-nonmodifiable-risk-factors-with-alzheimer-disease-40239154","doi":"10.1212/wnl.0000000000213500","journal":"Neurology","n_participants":9940,"pmid":"40239154","source_url":"https://pubmed.ncbi.nlm.nih.gov/40239154/","study_design":"cohort study","title":"Association of Nonmodifiable Risk Factors With Alzheimer Disease Blood Biomarkers in Community-Dwelling Adults in the ESTHER Study","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/influence-of-apoe-4-on-performance-of-csf-biomarkers-in-39827005","doi":"10.1016/j.tjpad.2025.100065","journal":"The journal of prevention of Alzheimer's disease","n_participants":1610,"pmid":"39827005","source_url":"https://pubmed.ncbi.nlm.nih.gov/39827005/","study_design":null,"title":"Influence of APOE \u03b54 on performance of CSF biomarkers in differentiating clinical Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/onset-of-alzheimer-disease-in-apolipoprotein-4-carriers-is-earlier-in-38594621","doi":"10.1186/s12883-024-03611-5","journal":"BMC neurology","n_participants":33,"pmid":"38594621","source_url":"https://pubmed.ncbi.nlm.nih.gov/38594621/","study_design":"post-hoc analysis","title":"Onset of Alzheimer disease in apolipoprotein \u025b4 carriers is earlier in butyrylcholinesterase K variant carriers","title_match":false,"year":2024},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/early-alzheimer-s-disease-blood-biomarkers-are-associated-with-a-42449187","doi":"10.1002/alz.71631","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":394,"pmid":"42449187","source_url":"https://pubmed.ncbi.nlm.nih.gov/42449187/","study_design":null,"title":"Early Alzheimer\u00b4s disease blood biomarkers are associated with a higher risk for postoperative long-term cognitive decline: Insights from the FINDERI study","title_match":false,"year":2026},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/genome-wide-association-studies-of-aria-from-the-aducanumab-phase-3-38165296","doi":"10.1212/wnl.0000000000207919","journal":"Neurology","n_participants":1691,"pmid":"38165296","source_url":"https://pubmed.ncbi.nlm.nih.gov/38165296/","study_design":"clinical trial","title":"Genome-Wide Association Studies of ARIA From the Aducanumab Phase 3 ENGAGE and EMERGE Studies","title_match":false,"year":2024},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/refractory-status-epilepticus-in-a-patient-with-aducanumab-induced-39121445","doi":"10.1212/wnl.0000000000209582","journal":"Neurology","n_participants":null,"pmid":"39121445","source_url":"https://pubmed.ncbi.nlm.nih.gov/39121445/","study_design":"longitudinal study","title":"Refractory Status Epilepticus in a Patient With Aducanumab-Induced Amyloid-Related Imaging Abnormalities","title_match":false,"year":2024},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/a-time-to-event-exposure-response-model-for-amyloid-related-imaging-35285968","doi":"10.1002/jcph.2047","journal":"Journal of clinical pharmacology","n_participants":3251,"pmid":"35285968","source_url":"https://pubmed.ncbi.nlm.nih.gov/35285968/","study_design":"clinical trial","title":"A Time-to-Event Exposure-Response Model for Amyloid-Related Imaging Abnormalities Following Administration of Aducanumab to Subjects With Early Alzheimer Disease","title_match":false,"year":2022},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/rosiglitazone-does-not-improve-cognition-or-global-function-when-used-21592048","doi":"10.2174/156720511796391935","journal":"Current Alzheimer research","n_participants":1496,"pmid":"21592048","source_url":"https://pubmed.ncbi.nlm.nih.gov/21592048/","study_design":"clinical trial","title":"Rosiglitazone does not improve cognition or global function when used as adjunctive therapy to AChE inhibitors in mild-to-moderate Alzheimer's disease: two phase 3 studies","title_match":false,"year":2011},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/gba-and-apoe-impact-cognitive-decline-in-parkinson-s-disease-a-10-35106798","doi":"10.1002/mds.28932","journal":"Movement disorders : official journal of the Movement Disorder Society","n_participants":281,"pmid":"35106798","source_url":"https://pubmed.ncbi.nlm.nih.gov/35106798/","study_design":"longitudinal study","title":"GBA and APOE Impact Cognitive Decline in Parkinson's Disease: A 10-Year Population-Based Study","title_match":false,"year":2022},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/the-development-and-convergence-of-co-pathologies-in-alzheimer-s-33449993","doi":"10.1093/brain/awaa438","journal":"Brain : a journal of neurology","n_participants":522,"pmid":"33449993","source_url":"https://pubmed.ncbi.nlm.nih.gov/33449993/","study_design":null,"title":"The development and convergence of co-pathologies in Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/head-trauma-and-risk-of-dementia-and-alzheimer-s-disease-the-10599765","doi":"10.1212/wnl.53.9.1959","journal":"Neurology","n_participants":6645,"pmid":"10599765","source_url":"https://pubmed.ncbi.nlm.nih.gov/10599765/","study_design":"cross-sectional","title":"Head trauma and risk of dementia and Alzheimer's disease: The Rotterdam Study","title_match":false,"year":1999},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/exposure-to-air-pollution-and-risk-of-incident-dementia-in-the-uk-35149105","doi":"10.1016/j.envres.2022.112895","journal":"Environmental research","n_participants":680,"pmid":"35149105","source_url":"https://pubmed.ncbi.nlm.nih.gov/35149105/","study_design":null,"title":"Exposure to air pollution and risk of incident dementia in the UK Biobank","title_match":false,"year":2022},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/association-between-apoe-e4-and-white-matter-hyperintensity-volume-30903549","doi":"10.1007/s11682-019-00069-9","journal":"Brain imaging and behavior","n_participants":8395,"pmid":"30903549","source_url":"https://pubmed.ncbi.nlm.nih.gov/30903549/","study_design":"cross-sectional","title":"Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity","title_match":true,"year":2020},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/the-impact-of-apoe-genotype-on-survival-results-of-38-537-31356640","doi":"10.1371/journal.pone.0219668","journal":"PloS one","n_participants":38537,"pmid":"31356640","source_url":"https://pubmed.ncbi.nlm.nih.gov/31356640/","study_design":"cohort study","title":"The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE)","title_match":false,"year":2019},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-genetic-risk-factor-apoe-e4-and-cognitive-abilities-27103599","doi":"10.1093/ageing/afw068","journal":"Age and ageing","n_participants":111739,"pmid":"27103599","source_url":"https://pubmed.ncbi.nlm.nih.gov/27103599/","study_design":null,"title":"Alzheimer disease genetic risk factor APOE e4 and cognitive abilities in 111,739 UK Biobank participants","title_match":true,"year":2016},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/cardiovascular-health-genetic-risk-and-risk-of-dementia-in-the-32690788","doi":"10.1212/wnl.0000000000010306","journal":"Neurology","n_participants":null,"pmid":"32690788","source_url":"https://pubmed.ncbi.nlm.nih.gov/32690788/","study_design":null,"title":"Cardiovascular health, genetic risk, and risk of dementia in the Framingham Heart Study","title_match":false,"year":2020},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/life-s-essential-8-cardiovascular-health-and-dementia-risk-cognition-37369360","doi":"10.1016/j.jamda.2023.05.023","journal":"Journal of the American Medical Directors Association","n_participants":316669,"pmid":"37369360","source_url":"https://pubmed.ncbi.nlm.nih.gov/37369360/","study_design":"cohort study","title":"\"Life's Essential 8\" Cardiovascular Health and Dementia Risk, Cognition, and Neuroimaging Markers of Brain Health","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/determinants-mri-correlates-and-prognosis-of-mild-cognitive-24825566","doi":"10.3233/jad-132558","journal":"Journal of Alzheimer's disease : JAD","n_participants":4198,"pmid":"24825566","source_url":"https://pubmed.ncbi.nlm.nih.gov/24825566/","study_design":null,"title":"Determinants, MRI correlates, and prognosis of mild cognitive impairment: the Rotterdam Study","title_match":false,"year":2014},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/late-life-body-mass-index-rapid-weight-loss-apolipoprotein-e-4-and-29188888","doi":"10.1007/s12603-017-0906-3","journal":"The journal of nutrition, health & aging","n_participants":5061,"pmid":"29188888","source_url":"https://pubmed.ncbi.nlm.nih.gov/29188888/","study_design":"cohort study","title":"Late-Life Body Mass Index, Rapid Weight Loss, Apolipoprotein E \u03b54 and the Risk of Cognitive Decline and Incident Dementia","title_match":true,"year":2017},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/association-of-a-wide-range-of-chronic-diseases-and-apolipoprotein-e4-35299656","doi":"10.1016/j.eclinm.2022.101335","journal":"EClinicalMedicine","n_participants":471485,"pmid":"35299656","source_url":"https://pubmed.ncbi.nlm.nih.gov/35299656/","study_design":"cohort study","title":"Association of a wide range of chronic diseases and apolipoprotein E4 genotype with subsequent risk of dementia in community-dwelling adults: A retrospective cohort study","title_match":true,"year":2022},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/effects-of-apoe4-and-maternal-history-of-dementia-on-hippocampal-20833446","doi":"10.1016/j.neurobiolaging.2010.07.020","journal":"Neurobiology of aging","n_participants":243,"pmid":"20833446","source_url":"https://pubmed.ncbi.nlm.nih.gov/20833446/","study_design":null,"title":"Effects of ApoE4 and maternal history of dementia on hippocampal atrophy","title_match":true,"year":2012},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/quantitative-validation-of-a-visual-rating-scale-for-frontal-atrophy-26560730","doi":"10.1007/s00330-015-4101-9","journal":"European radiology","n_participants":329,"pmid":"26560730","source_url":"https://pubmed.ncbi.nlm.nih.gov/26560730/","study_design":null,"title":"Quantitative validation of a visual rating scale for frontal atrophy: associations with clinical status, APOE e4, CSF biomarkers and cognition","title_match":true,"year":2016},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/differential-associations-of-apoe-2-and-apoe-4-alleles-with-pet-33521872","doi":"10.1007/s00259-021-05192-8","journal":"European journal of nuclear medicine and molecular imaging","n_participants":156,"pmid":"33521872","source_url":"https://pubmed.ncbi.nlm.nih.gov/33521872/","study_design":"cross-sectional","title":"Differential associations of APOE-\u03b52 and APOE-\u03b54 alleles with PET-measured amyloid-\u03b2 and tau deposition in older individuals without dementia","title_match":true,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/insomnia-symptom-severity-and-cognitive-performance-moderating-role-34310026","doi":"10.1002/alz.12405","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"34310026","source_url":"https://pubmed.ncbi.nlm.nih.gov/34310026/","study_design":null,"title":"Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype","title_match":false,"year":2022},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/functional-brain-abnormalities-in-young-adults-at-genetic-risk-for-14688411","doi":"10.1073/pnas.2635903100","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"14688411","source_url":"https://pubmed.ncbi.nlm.nih.gov/14688411/","study_design":null,"title":"Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia","title_match":false,"year":2004},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/longitudinal-modeling-of-age-related-memory-decline-and-the-apoe-19605830","doi":"10.1056/nejmoa0809437","journal":"The New England journal of medicine","n_participants":815,"pmid":"19605830","source_url":"https://pubmed.ncbi.nlm.nih.gov/19605830/","study_design":"longitudinal study","title":"Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect","title_match":true,"year":2009},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/correlations-between-apolipoprotein-e-epsilon4-gene-dose-and-brain-15932949","doi":"10.1073/pnas.0500579102","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"15932949","source_url":"https://pubmed.ncbi.nlm.nih.gov/15932949/","study_design":null,"title":"Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism","title_match":true,"year":2005},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-allele-in-a-population-based-study-of-early-onset-8075646","doi":"10.1038/ng0594-74","journal":"Nature genetics","n_participants":null,"pmid":"8075646","source_url":"https://pubmed.ncbi.nlm.nih.gov/8075646/","study_design":null,"title":"Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease","title_match":true,"year":1994},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/hypothesis-microtubule-instability-and-paired-helical-filament-8313935","doi":"10.1006/exnr.1994.1019","journal":"Experimental neurology","n_participants":null,"pmid":"8313935","source_url":"https://pubmed.ncbi.nlm.nih.gov/8313935/","study_design":null,"title":"Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype","title_match":false,"year":1994},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/genetic-association-of-the-low-density-lipoprotein-receptor-related-9222170","doi":"10.1212/wnl.49.1.56","journal":"Neurology","n_participants":null,"pmid":"9222170","source_url":"https://pubmed.ncbi.nlm.nih.gov/9222170/","study_design":null,"title":"Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease","title_match":false,"year":1997},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/apoe-epsilon-4-lowers-age-at-onset-and-is-a-high-risk-factor-for-18416843","doi":"10.1186/1471-2377-8-9","journal":"BMC neurology","n_participants":376,"pmid":"18416843","source_url":"https://pubmed.ncbi.nlm.nih.gov/18416843/","study_design":null,"title":"APOE epsilon 4 lowers age at onset and is a high risk factor for Alzheimer's disease; a case control study from central Norway","title_match":true,"year":2008},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/higher-rates-of-decline-for-women-and-apolipoprotein-e-epsilon4-23828104","doi":"10.3174/ajnr.a3601","journal":"AJNR. American journal of neuroradiology","n_participants":null,"pmid":"23828104","source_url":"https://pubmed.ncbi.nlm.nih.gov/23828104/","study_design":"longitudinal study","title":"Higher rates of decline for women and apolipoprotein E epsilon4 carriers","title_match":true,"year":2013},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-allele-epsilon-4-dementia-and-cognitive-decline-in-a-7475820","doi":"10.1016/s0140-6736(95)92405-1","journal":"Lancet (London, England)","n_participants":638,"pmid":"7475820","source_url":"https://pubmed.ncbi.nlm.nih.gov/7475820/","study_design":null,"title":"Apolipoprotein E allele epsilon 4, dementia, and cognitive decline in a population sample","title_match":false,"year":1995},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/psen1e9-appswe-and-apoe4-confer-disparate-phenotypes-in-human-ipsc-31522977","doi":"10.1016/j.stemcr.2019.08.004","journal":"Stem cell reports","n_participants":null,"pmid":"31522977","source_url":"https://pubmed.ncbi.nlm.nih.gov/31522977/","study_design":null,"title":"PSEN1\u0394E9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia","title_match":true,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-induces-lipid-accumulation-through-dgat2-that-is-39596576","doi":"10.3390/genes15111376","journal":"Genes","n_participants":null,"pmid":"39596576","source_url":"https://pubmed.ncbi.nlm.nih.gov/39596576/","study_design":null,"title":"Apolipoprotein E Induces Lipid Accumulation Through Dgat2 That Is Prevented with Time-Restricted Feeding in Drosophila","title_match":false,"year":2024},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/depression-is-associated-with-dementia-and-accelerated-cognitive-a2039439","doi":"10.1002/alz.077404","journal":"Alzheimer s & Dementia","n_participants":261,"pmid":null,"source_url":"https://doi.org/10.1002/alz.077404","study_design":null,"title":"Depression is associated with dementia and accelerated cognitive decline in African Americans","title_match":false,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/both-targeted-mass-spectrometry-and-flow-sorting-analysis-methods-24319058","doi":"10.1074/mcp.m113.028639","journal":"Molecular & Cellular Proteomics","n_participants":null,"pmid":"24319058","source_url":"https://pubmed.ncbi.nlm.nih.gov/24319058/","study_design":null,"title":"Both Targeted Mass Spectrometry and Flow Sorting Analysis Methods Detected the Decreased Serum Apolipoprotein E Level in Alzheimer's Disease Patients","title_match":false,"year":2013},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/the-association-of-neighborhood-socioeconomic-status-with-executive-38663362","doi":"10.1159/000539035","journal":"Dementia and Geriatric Cognitive Disorders","n_participants":1312,"pmid":"38663362","source_url":"https://pubmed.ncbi.nlm.nih.gov/38663362/","study_design":"longitudinal study","title":"The Association of Neighborhood Socioeconomic Status with Executive Function and Processing Speed in Cognitively Normal Mexican American Elders from the Health and Aging Brains Study: Health Disparities Cohort","title_match":false,"year":2024},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/associations-among-cognitive-performance-vcam-1-and-gfap-in-black-42431159","doi":"10.1016/j.neurobiolaging.2026.07.003","journal":"Neurobiology of Aging","n_participants":313,"pmid":"42431159","source_url":"https://pubmed.ncbi.nlm.nih.gov/42431159/","study_design":"cross-sectional","title":"Associations among cognitive performance, VCAM-1, and GFAP in black adults: The ARCHES study","title_match":false,"year":2026},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/older-adults-in-more-disadvantaged-neighborhoods-exhibit-brain-75b8b974","doi":"10.1016/j.cccb.2026.100562","journal":"Cerebral Circulation - Cognition and Behavior","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1016/j.cccb.2026.100562","study_design":null,"title":"Older adults in more disadvantaged neighborhoods exhibit brain vascular dysfunction","title_match":false,"year":2026},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/socioeconomic-deprivation-and-medical-comorbidity-burden-associations-41444806","doi":"10.1002/alz70855_107360","journal":"Alzheimer s & Dementia","n_participants":75,"pmid":"41444806","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12738506/","study_design":null,"title":"Socioeconomic deprivation and medical comorbidity burden associations with clinicopathologic characteristics in an ethnoracially diverse Alzheimer's disease autopsy series","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/evaluation-of-a-panel-of-plasma-biomarkers-for-alzheimer-s-disease-in-41212652","doi":"10.1177/13872877251393405","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"41212652","source_url":"https://pubmed.ncbi.nlm.nih.gov/41212652/","study_design":null,"title":"Evaluation of a panel of plasma biomarkers for Alzheimer's disease in a diverse research cohort","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/associations-of-longitudinal-changes-in-blood-biomarkers-of-dementia-40779734","doi":"10.1212/wnl.0000000000213976","journal":"Neurology","n_participants":null,"pmid":"40779734","source_url":"https://pubmed.ncbi.nlm.nih.gov/40779734/","study_design":"cross-sectional","title":"Associations of Longitudinal Changes in Blood Biomarkers of Dementia With the Proportion of Genetically Inferred African Ancestry","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/impaired-lung-function-is-associated-with-elevated-blood-biomarkers-40492085","doi":"10.1038/s41598-026-48115-z","journal":"Scientific Reports","n_participants":4072,"pmid":"40492085","source_url":"https://pubmed.ncbi.nlm.nih.gov/40492085/","study_design":null,"title":"Impaired lung function is associated with elevated blood biomarkers of AD/ADRD: unraveling the interplay with risk of dementia","title_match":false,"year":2026},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/effects-of-lowintensity-ultrasound-on-amyloid-clearance-in-earlystage-c42da504","doi":"10.1155/ane/1538313","journal":"Acta Neurologica Scandinavica","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1155/ane/1538313","study_design":null,"title":"Effects of Low\u2010Intensity Ultrasound on Amyloid\u2010 \u03b2 Clearance in Early\u2010Stage Alzheimer\u2032s Disease: A Potential Role of Glymphatic Activity","title_match":false,"year":2026},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-blood-biomarkers-and-cognition-in-midlife-41447483","doi":"10.1002/alz70856_101201","journal":"Alzheimer s & Dementia","n_participants":1356,"pmid":"41447483","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12740106/","study_design":null,"title":"Alzheimer disease blood biomarkers and cognition in midlife","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/modulatory-effect-of-glial-fibrillary-acidic-protein-gfap-levels-on-ec93d4d3","doi":"10.1002/alz70856_106267","journal":"Alzheimer s & Dementia","n_participants":354,"pmid":null,"source_url":"https://doi.org/10.1002/alz70856_106267","study_design":"longitudinal study","title":"Modulatory effect of glial fibrillary acidic protein (GFAP) levels on the association between plasma p \u2010tau217 levels and cognitive decline in older adults","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/indices-of-arterial-stiffness-and-the-alzheimers-disease-biomarker-p-42325223","doi":"10.1159/000552328","journal":"Pulse","n_participants":871,"pmid":"42325223","source_url":"https://pubmed.ncbi.nlm.nih.gov/42325223/","study_design":"cross-sectional","title":"Indices of Arterial Stiffness and the Alzheimer\u2019s Disease Biomarker, p-tau217, in Non-Demented Midlife Women","title_match":false,"year":2026},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/apoe-genotyping-and-12month-longitudinal-tracking-of-p-tau217-using-bcf50737","doi":"10.1002/alz70856_106796","journal":"Alzheimer s & Dementia","n_participants":58,"pmid":null,"source_url":"https://doi.org/10.1002/alz70856_106796","study_design":"longitudinal study","title":"ApoE Genotyping and 12\u2010Month Longitudinal Tracking of p \u2010Tau217 Using Fingerstick Collection in a Population\u2010Based Cohort","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/dream-recall-in-cognitively-healthy-older-adults-associations-with-41444446","doi":"10.1002/alz70857_097922","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41444446","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12738213/","study_design":"longitudinal study","title":"Dream recall in cognitively healthy older adults: associations with blood p \u2010tau217 levels, APOE \u03b54 carriage, and cognitive decline","title_match":true,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/differing-network-patterns-of-functional-connectivity-and-amyloid-pet-41434143","doi":"10.1002/alz70862_109964","journal":"Alzheimer s & Dementia","n_participants":690,"pmid":"41434143","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12726122/","study_design":null,"title":"Differing network patterns of functional connectivity and amyloid PET between tau PET subtypes","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/age-related-prevalence-of-abnormal-plasma-p-tau217-across-racial-2e7b0be9","doi":"10.1212/wn9.0000000000000145","journal":"Neurology Open Access","n_participants":2798,"pmid":null,"source_url":"https://doi.org/10.1212/wn9.0000000000000145","study_design":"cross-sectional","title":"Age-Related Prevalence of Abnormal Plasma p-Tau217 Across Racial Ethnic Groups in the Health and Aging Brain Study-Health Disparities","title_match":false,"year":2026},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/differing-network-patterns-of-functional-connectivity-and-amyloid-pet-41442473","doi":"10.1002/alz70856_097884","journal":"Alzheimer s & Dementia","n_participants":690,"pmid":"41442473","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12734641/","study_design":null,"title":"Differing network patterns of functional connectivity and amyloid PET between tau PET subtypes","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/cross-sectional-associations-of-plasma-vitamin-d-with-plasma-40706903","doi":"10.1016/j.nbd.2025.107041","journal":"Neurobiology of Disease","n_participants":311,"pmid":"40706903","source_url":"https://pubmed.ncbi.nlm.nih.gov/40706903/","study_design":"cross-sectional","title":"Cross-sectional associations of plasma vitamin D with plasma phosphorylated tau-181 and plasma neurofilament light chain in older adults with memory complaints","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/associations-of-18-f-pi-2620-binding-with-memory-and-phosphorylated-42463287","doi":"10.2967/jnumed.125.271927","journal":"Journal of Nuclear Medicine","n_participants":null,"pmid":"42463287","source_url":"https://pubmed.ncbi.nlm.nih.gov/42463287/","study_design":null,"title":"Associations of [ 18 F]PI-2620 Binding with Memory and Phosphorylated Tau 217 in Cognitively Unimpaired Older Adults","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-spectrum-of-genetic-risk-in-alzheimer-disease-39885961","doi":"10.1212/nxg.0000000000200224","journal":"Neurology Genetics","n_participants":null,"pmid":"39885961","source_url":"https://pubmed.ncbi.nlm.nih.gov/39885961/","study_design":null,"title":"The Spectrum of Genetic Risk in Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/higher-level-of-3h-ucb-j-binding-in-apoe-4-allele-carriers-with-39900278","doi":"10.1016/j.neulet.2025.138135","journal":"Neuroscience Letters","n_participants":null,"pmid":"39900278","source_url":"https://pubmed.ncbi.nlm.nih.gov/39900278/","study_design":null,"title":"Higher level of [3H]UCB-J binding in ApoE \u01904 allele carriers with Alzheimer disease","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/clinical-biological-and-functional-connectivity-profile-of-patients-41348997","doi":"10.1212/wnl.0000000000214449","journal":"Neurology","n_participants":null,"pmid":"41348997","source_url":"https://pubmed.ncbi.nlm.nih.gov/41348997/","study_design":null,"title":"Clinical, Biological, and Functional Connectivity Profile of Patients With De Novo Parkinson Disease Who Are APOE \u03b54 Carriers","title_match":true,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/apoe-4-and-accelerated-cognitive-decline-among-cognitively-healthy-41790466","doi":"10.1001/jamanetworkopen.2026.0853","journal":"JAMA Network Open","n_participants":4392,"pmid":"41790466","source_url":"https://pubmed.ncbi.nlm.nih.gov/41790466/","study_design":"cohort study","title":"APOE \u03b54 and Accelerated Cognitive Decline Among Cognitively Healthy Middle-Aged and Older Adults","title_match":true,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/time-course-and-severity-of-cognitive-changes-as-a-function-of-a-40577676","doi":"10.1212/wnl.0000000000213853","journal":"Neurology","n_participants":1542,"pmid":"40577676","source_url":"https://pubmed.ncbi.nlm.nih.gov/40577676/","study_design":null,"title":"Time Course and Severity of Cognitive Changes as a Function of A\u03b2 Positivity and APOE Genotype in Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/apoe-4-and-risk-of-intracranial-hemorrhage-in-patients-with-atrial-40549373","doi":"10.1001/jamaneurol.2025.0182","journal":"JAMA Neurology","n_participants":26,"pmid":"40549373","source_url":"https://pubmed.ncbi.nlm.nih.gov/40549373/","study_design":"cohort study","title":"APOE \u03b54 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban","title_match":true,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apoe4-upregulates-gsk-3-to-aggravate-alzheimerlike-pathologies-and-40905109","doi":"10.1111/cns.70575","journal":"CNS Neuroscience & Therapeutics","n_participants":null,"pmid":"40905109","source_url":"https://pubmed.ncbi.nlm.nih.gov/40905109/","study_design":null,"title":"ApoE4 Upregulates GSK \u20103\u03b2 to Aggravate Alzheimer\u2010Like Pathologies and Cognitive Impairment in Type 2 Diabetic Mice","title_match":true,"year":2025},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/longitudinal-assessment-of-cognitive-decline-and-resilience-in-high-41339920","doi":"10.1186/s13195-025-01904-6","journal":"Alzheimer s Research & Therapy","n_participants":75,"pmid":"41339920","source_url":"https://pubmed.ncbi.nlm.nih.gov/41339920/","study_design":"cohort study","title":"Longitudinal assessment of cognitive decline and resilience in high-level Alzheimer disease neuropathologic change","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/sex-differences-in-alzheimer-disease-imaging-biomarkers-in-a-diverse-41591778","doi":"10.1001/jamanetworkopen.2025.54524","journal":"JAMA Network Open","n_participants":501,"pmid":"41591778","source_url":"https://pubmed.ncbi.nlm.nih.gov/41591778/","study_design":"cross-sectional","title":"Sex Differences in Alzheimer Disease Imaging Biomarkers in a Diverse, Community-Based Cohort","title_match":false,"year":2026},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/amyloid-imaging-and-apoe-genotype-disclosure-and-short-term-41910973","doi":"10.1001/jamanetworkopen.2026.3845","journal":"JAMA Network Open","n_participants":1184,"pmid":"41910973","source_url":"https://pubmed.ncbi.nlm.nih.gov/41910973/","study_design":"cohort study","title":"Amyloid Imaging and APOE Genotype Disclosure and Short-Term Psychological Distress","title_match":false,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apoe-4-linked-effects-on-clinical-features-and-neuropathology-in-41074912","doi":"10.1002/alz.70795","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41074912","source_url":"https://pubmed.ncbi.nlm.nih.gov/41074912/","study_design":null,"title":"APOE \u03b54 linked effects on clinical features and neuropathology in dementia with Lewy bodies","title_match":true,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/population-attributable-risk-in-alzheimer-and-parkinson-diseases-42639394","doi":"10.1212/nxg.0000000000200415","journal":"Neurology Genetics","n_participants":null,"pmid":"42639394","source_url":"https://pubmed.ncbi.nlm.nih.gov/42639394/","study_design":"meta-analysis","title":"Population Attributable Risk in Alzheimer and Parkinson Diseases","title_match":false,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/role-of-apolipoprotein-e-apoe-4-in-cognitive-impairment-after-a-40349252","doi":"10.18632/aging.206248","journal":"Aging","n_participants":null,"pmid":"40349252","source_url":"https://pubmed.ncbi.nlm.nih.gov/40349252/","study_design":"cohort study","title":"Role of apolipoprotein E (ApoE) \u03b54 in cognitive impairment after a stroke: a prospective cohort study","title_match":true,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/exploring-immediate-responses-to-apoe-4-4-genotype-and-alzheimer-s-41906765","doi":"10.1177/13872877261435633","journal":"Journal of Alzheimer s Disease","n_participants":61,"pmid":"41906765","source_url":"https://pubmed.ncbi.nlm.nih.gov/41906765/","study_design":null,"title":"Exploring immediate responses to APOE \u03b5 4/\u03b54 genotype and Alzheimer's disease risk disclosure in Latinos","title_match":true,"year":2026},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/red-blood-cell-3-status-and-longitudinal-cognition-in-individuals-at-41022152","doi":"10.1016/j.tjnut.2025.09.032","journal":"Journal of Nutrition","n_participants":323,"pmid":"41022152","source_url":"https://pubmed.ncbi.nlm.nih.gov/41022152/","study_design":"longitudinal study","title":"Red blood cell \u03c9-3 status and longitudinal cognition in individuals at risk of Alzheimer disease","title_match":false,"year":2025},{"alzhub_score":28,"alzhub_url":"https://alzhub.org/study/neuropsychiatric-symptoms-of-alzheimer-disease-parkinson-disease-and-371f2186","doi":"10.20900/agmr20250013","journal":"Advances in Geriatric Medicine and Research","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.20900/agmr20250013","study_design":null,"title":"Neuropsychiatric Symptoms of Alzheimer Disease, Parkinson Disease and Lewy Body Dementia: Genetic, Clinical and Therapeutic Overlaps","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/clinical-and-pathologic-correlations-of-machine-learning-41806384","doi":"10.1093/jnen/nlaf152","journal":"Journal of Neuropathology & Experimental Neurology","n_participants":273,"pmid":"41806384","source_url":"https://pubmed.ncbi.nlm.nih.gov/41806384/","study_design":null,"title":"Clinical and pathologic correlations of machine learning quantification of A\u03b2 deposits across 3 brain regions of decedents with Alzheimer disease","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/early-behavioral-and-cognitive-changes-in-patients-with-41809433","doi":"10.1212/wn9.0000000000000055","journal":"Neurology Open Access","n_participants":1028,"pmid":"41809433","source_url":"https://pubmed.ncbi.nlm.nih.gov/41809433/","study_design":"cohort study","title":"Early Behavioral and Cognitive Changes in Patients With Pathologically Confirmed Alzheimer Disease, Lewy Body Dementia, and Mixed Dementia","title_match":false,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/interaction-of-sortilin-with-apolipoprotein-e3-enables-neurons-to-use-41102453","doi":"10.1038/s42255-025-01389-5","journal":"Nature Metabolism","n_participants":null,"pmid":"41102453","source_url":"https://pubmed.ncbi.nlm.nih.gov/41102453/","study_design":null,"title":"Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel","title_match":false,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/combating-genetic-heterogeneity-for-polygenic-prediction-of-40703204","doi":"10.1212/nxg.0000000000200266","journal":"Neurology Genetics","n_participants":null,"pmid":"40703204","source_url":"https://pubmed.ncbi.nlm.nih.gov/40703204/","study_design":null,"title":"Combating Genetic Heterogeneity for Polygenic Prediction of Susceptibility to Brain \u03b2-Amyloid Deposition","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/predictive-value-of-the-alzheimer-polygenic-risk-score-on-cognitive-42594416","doi":"10.1016/j.tjpad.2026.100658","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":7233,"pmid":"42594416","source_url":"https://pubmed.ncbi.nlm.nih.gov/42594416/","study_design":"longitudinal study","title":"Predictive value of the Alzheimer polygenic risk score on cognitive decline in patients with mild cognitive impairment and Alzheimer's disease dementia","title_match":false,"year":2026},{"alzhub_score":30,"alzhub_url":"https://alzhub.org/study/genomewide-analysis-of-memory-language-and-executive-function-reveals-41442684","doi":"10.1002/alz70855_105459","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41442684","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12737550/","study_design":null,"title":"Genome\u2010Wide Analysis of Memory, Language, and Executive Function Reveals Domain\u2010Specific Genetic Architecture in Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/a-apolipoproteina-e-apoe-e-suas-isoformas-na-doenca-de-alzheimer-8439ddad","doi":"10.56083/rcv5n12-114","journal":"Revista Contempor\u00e2nea","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.56083/rcv5n12-114","study_design":null,"title":"A APOLIPOPROTEINA E (APOE) E SUAS ISOFORMAS NA DOEN\u00c7A DE ALZHEIMER","title_match":false,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/effects-of-sexual-differentiation-and-apoe-genotype-on-the-93b65e21","doi":"10.1186/s13293-026-00967-w","journal":"Biology of Sex Differences","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1186/s13293-026-00967-w","study_design":null,"title":"Effects of sexual differentiation and APOE genotype on the development of Alzheimer-related pathology in female EFAD mice","title_match":false,"year":2026},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/lysosomal-proteomics-reveals-mechanisms-of-neuronal-apoe4-associated-41103078","doi":"10.1080/15548627.2025.2576613","journal":"Autophagy","n_participants":null,"pmid":"41103078","source_url":"https://pubmed.ncbi.nlm.nih.gov/41103078/","study_design":null,"title":"Lysosomal proteomics reveals mechanisms of neuronal APOE4-associated lysosomal dysfunction","title_match":true,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/dissecting-alzheimer-disease-heritability-across-multiple-populations-41436227","doi":"10.1002/alz70855_102132","journal":"Alzheimer s & Dementia","n_participants":7024,"pmid":"41436227","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12727212/","study_design":null,"title":"Dissecting Alzheimer Disease Heritability Across Multiple Populations","title_match":false,"year":2025},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/novel-drug-delivery-system-a-pandora-box-for-the-manage-ment-of-f13bd11e","doi":"10.4238/0fganh12","journal":"Genetics and Molecular Research","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.4238/0fganh12","study_design":null,"title":"NOVEL DRUG DELIVERY SYSTEM: A PANDORA BOX FOR THE MANAGE MENT OF ALZHEIMER NOVEL DRUG DELIVERY IN ALZHEIMER","title_match":false,"year":2026},{"alzhub_score":28,"alzhub_url":"https://alzhub.org/study/prediction-of-alzheimer-patients-with-machine-learning-algorithms-3ad6cbcf","doi":"10.33022/ijcs.v14i3.4364","journal":"Indonesian Journal of Computer Science","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.33022/ijcs.v14i3.4364","study_design":null,"title":"Prediction Of Alzheimer Patients with Machine Learning Algorithms","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/active-travel-mode-and-incident-dementia-and-brain-structure-40489111","doi":"10.1001/jamanetworkopen.2025.14316","journal":"JAMA Network Open","n_participants":723,"pmid":"40489111","source_url":"https://pubmed.ncbi.nlm.nih.gov/40489111/","study_design":"cohort study","title":"Active Travel Mode and Incident Dementia and Brain Structure","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/peruvian-population-empowers-discovery-of-a-trem2-missense-variant-in-41444117","doi":"10.1002/alz70855_105970","journal":"Alzheimer s & Dementia","n_participants":567,"pmid":"41444117","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12738110/","study_design":null,"title":"Peruvian Population Empowers Discovery of a TREM2 Missense Variant in Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":26,"alzhub_url":"https://alzhub.org/study/tek-bir-gen-alzheimer-vakalarnn-buyuk-bolumunu-acklayabilir-b8311bc1","doi":"10.32739/uha.id.66186","journal":"\u00fcha","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.32739/uha.id.66186","study_design":null,"title":"Tek Bir Gen Alzheimer Vakalar\u0131n\u0131n B\u00fcy\u00fck B\u00f6l\u00fcm\u00fcn\u00fc A\u00e7\u0131klayabilir","title_match":false,"year":2026},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/dissecting-the-genetic-and-proteomic-risk-factors-for-delirium-41286463","doi":"10.1038/s43587-025-01018-6","journal":"Nature Aging","n_participants":1059130,"pmid":"41286463","source_url":"https://pubmed.ncbi.nlm.nih.gov/41286463/","study_design":"meta-analysis","title":"Dissecting the genetic and proteomic risk factors for delirium","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apoe-4-and-cognition-among-middle-aged-and-older-east-asian-adults-41790473","doi":"10.1001/jamanetworkopen.2026.0860","journal":"JAMA Network Open","n_participants":21,"pmid":"41790473","source_url":"https://pubmed.ncbi.nlm.nih.gov/41790473/","study_design":"longitudinal study","title":"APOE \u03b54 and Cognition Among Middle-Aged and Older East Asian Adults","title_match":true,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/tau-is-associated-with-atrophy-in-mci-independently-of-betaamyloid-41447351","doi":"10.1002/alz70856_102268","journal":"Alzheimer s & Dementia","n_participants":222,"pmid":"41447351","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12739983/","study_design":"cross-sectional","title":"Tau is associated with atrophy in MCI independently of beta\u2010amyloid and APOE e4 genotype","title_match":true,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/multimorbidity-cognition-and-alzheimer-disease-biomarkers-a-pathway-41434402","doi":"10.1002/alz70862_110144","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41434402","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12725342/","study_design":null,"title":"Multimorbidity, Cognition, and Alzheimer Disease Biomarkers: A Pathway Analysis","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-fall-dementia-connection-synergistic-effects-of-falls-with-40325974","doi":"10.1177/13872877251333799","journal":"Journal of Alzheimer s Disease","n_participants":403502,"pmid":"40325974","source_url":"https://pubmed.ncbi.nlm.nih.gov/40325974/","study_design":null,"title":"The fall-dementia connection: Synergistic effects of falls with genetic and health risk factors","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/anti-amyloid-monoclonal-antibodies-in-early-alzheimer-disease-42784125","doi":"10.3390/neurolint18090171","journal":"Neurology International","n_participants":null,"pmid":"42784125","source_url":"https://pubmed.ncbi.nlm.nih.gov/42784125/","study_design":"meta-analysis","title":"Anti-Amyloid Monoclonal Antibodies in Early Alzheimer Disease: Lecanemab and Donanemab","title_match":false,"year":2026},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/cerebral-microbleeds-and-amyloid-pathology-estimates-from-the-amyloid-39841474","doi":"10.1001/jamanetworkopen.2024.55571","journal":"JAMA Network Open","n_participants":4080,"pmid":"39841474","source_url":"https://pubmed.ncbi.nlm.nih.gov/39841474/","study_design":"cross-sectional","title":"Cerebral Microbleeds and Amyloid Pathology Estimates From the Amyloid Biomarker Study","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/exploring-potential-mechanisms-of-an-african-protective-locus-for-40704449","doi":"10.1002/alz.70500","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40704449","source_url":"https://pubmed.ncbi.nlm.nih.gov/40704449/","study_design":null,"title":"Exploring potential mechanisms of an African protective locus for Alzheimer's disease in APOE\u03b54 carriers","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/genetic-modifiers-of-abca1-activity-interact-with-apoe-isoforms-to-42548036","doi":"10.1002/ana.78303","journal":"Annals of Neurology","n_participants":null,"pmid":"42548036","source_url":"https://pubmed.ncbi.nlm.nih.gov/42548036/","study_design":null,"title":"Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk","title_match":false,"year":2026},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/apoe-genotype-modulates-the-relationship-of-stroke-with-dementia-risk-41404739","doi":"10.1161/jaha.125.043446","journal":"Journal of the American Heart Association","n_participants":336,"pmid":"41404739","source_url":"https://pubmed.ncbi.nlm.nih.gov/41404739/","study_design":"cohort study","title":"APOE Genotype Modulates the Relationship of Stroke With Dementia Risk: Associations and Peripheral Clues for Biological Mechanisms","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/sex-differences-in-alzheimer-disease-imaging-biomarkers-in-a-diverse-aaf27875","doi":"10.17615/nfd5-v552","journal":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","n_participants":501,"pmid":null,"source_url":"https://doi.org/10.17615/nfd5-v552","study_design":"cross-sectional","title":"Sex Differences in Alzheimer Disease Imaging Biomarkers in a Diverse, Community-Based Cohort","title_match":false,"year":2026},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/leveraging-african-ancestry-diversity-for-global-advances-in-41442731","doi":"10.1002/alz70855_105506","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41442731","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12737828/","study_design":null,"title":"Leveraging African Ancestry Diversity for Global Advances in Alzheimer Disease Genetics","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/interactive-effects-of-telomere-length-and-genetic-variants-on-41857676","doi":"10.1186/s13195-026-02005-8","journal":"Alzheimer s Research & Therapy","n_participants":6973,"pmid":"41857676","source_url":"https://pubmed.ncbi.nlm.nih.gov/41857676/","study_design":null,"title":"Interactive effects of telomere length and genetic variants on Alzheimer disease risk across multiple ancestral populations","title_match":false,"year":2026},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/the-interplay-of-picalm-with-apoe-4-on-alzheimers-disease-clues-from-0e28a66d","doi":"10.1038/s41398-026-04453-0","journal":"Translational Psychiatry","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1038/s41398-026-04453-0","study_design":null,"title":"The interplay of PICALM with APOE \u03b54 on Alzheimer\u2019s disease: clues from two longitudinal cohorts and proteomic studies","title_match":true,"year":2026},{"alzhub_score":32,"alzhub_url":"https://alzhub.org/study/ibuprofen-modulates-inflammatory-and-autophagy-associated-pathways-e38b6498","doi":"10.1186/s12974-026-04038-0","journal":"Journal of Neuroinflammation","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1186/s12974-026-04038-0","study_design":null,"title":"Ibuprofen modulates inflammatory and autophagy-associated pathways linked to neurodegenerative pathology in APOE-context-dependent cellular models","title_match":false,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/remote-assessments-of-sleep-and-cognition-in-cognitively-normal-older-41456359","doi":"10.1016/j.sleep.2025.108734","journal":"Sleep Medicine","n_participants":319,"pmid":"41456359","source_url":"https://pubmed.ncbi.nlm.nih.gov/41456359/","study_design":null,"title":"Remote assessments of sleep and cognition in cognitively normal older adults at risk for Alzheimer disease","title_match":false,"year":2025},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/o-impacto-da-genetica-e-fatores-epigeneticos-no-desenvolvimento-do-4f8b0b66","doi":"10.36557/2674-8169.2025v7n4p1163-1180","journal":"Brazilian Journal of Implantology and Health Sciences","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.36557/2674-8169.2025v7n4p1163-1180","study_design":null,"title":"O impacto da gen\u00e9tica e fatores epigen\u00e9ticos no desenvolvimento do Alzheimer","title_match":false,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/protection-against-apoe4-associated-phenotypes-with-the-longevity-40494894","doi":"10.1038/s43856-025-00942-3","journal":"Communications Medicine","n_participants":null,"pmid":"40494894","source_url":"https://pubmed.ncbi.nlm.nih.gov/40494894/","study_design":null,"title":"Protection against APOE4-associated phenotypes with the longevity-promoting intervention 17\u03b1-estradiol in middle-aged male mice","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/mapping-sex-differences-in-brain-and-cognition-in-relation-to-apoe-4-00ddbfb1","doi":"10.1002/trc2.70223","journal":"Alzheimer s & Dementia Translational Research & Clinical Interventions","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1002/trc2.70223","study_design":"longitudinal study","title":"Mapping sex differences in brain and cognition in relation to APOE \u03b54 and amyloid burden: A longitudinal normative modelling study","title_match":true,"year":2026},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/regional-distribution-of-mineralized-blood-vessels-in-alzheimer-f73fe408","doi":"10.1016/j.neurobiolaging.2026.09.001","journal":"Neurobiology of Aging","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1016/j.neurobiolaging.2026.09.001","study_design":null,"title":"Regional Distribution of Mineralized Blood Vessels in Alzheimer Disease and Clinicopathological Associations: A Multicenter Autopsy Study","title_match":false,"year":2026},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/alzheimerrelated-neuropathology-is-improved-by-treatment-with-41435356","doi":"10.1002/alz70855_099102","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41435356","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12726874/","study_design":null,"title":"Alzheimer\u2010related neuropathology is improved by treatment with longevity\u2010enhancing treatments in aged male EFAD mice","title_match":false,"year":2025},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/rs140926439-variant-in-the-fibronectin-fn1-gene-lowers-risk-of-41195593","doi":"10.1097/wad.0000000000000692","journal":"Alzheimer Disease & Associated Disorders","n_participants":null,"pmid":"41195593","source_url":"https://pubmed.ncbi.nlm.nih.gov/41195593/","study_design":null,"title":"rs140926439 Variant in the Fibronectin FN1 Gene Lowers Risk of Alzheimer Disease in APOE\u03b54 Carriers in the UK Biobank Cohort","title_match":true,"year":2025},{"alzhub_score":26,"alzhub_url":"https://alzhub.org/study/exploring-the-pathogenesis-of-alzheimer-disease-in-basal-forebrain-521df110","doi":"10.25258/ijddt.16.32s.128","journal":"International Journal of Drug Delivery Technology","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.25258/ijddt.16.32s.128","study_design":null,"title":"Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons and Converging Insights from Alternative Hypothesis","title_match":false,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/brain-tau-pet-based-identification-and-characterization-of-40488912","doi":"10.1186/s40658-025-00761-4","journal":"EJNMMI Physics","n_participants":615,"pmid":"40488912","source_url":"https://pubmed.ncbi.nlm.nih.gov/40488912/","study_design":null,"title":"Brain tau PET-based identification and characterization of subpopulations in patients with Alzheimer\u2019s disease using deep learning-derived saliency maps","title_match":false,"year":2025},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/panorama-clinico-e-epidemiologico-da-doenca-de-alzheimer-no-brasil-fb98eff3","doi":"10.55905/revconv.19n.9-010","journal":"Contribuciones a las Ciencias Sociales","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.55905/revconv.19n.9-010","study_design":null,"title":"Panorama cl\u00ednico e epidemiol\u00f3gico da doen\u00e7a de Alzheimer no Brasil: desafios atuais e perspectivas","title_match":false,"year":2026},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/pet-guided-assessment-of-amyloid-clearance-and-outcomes-in-a-real-42055956","doi":"10.3174/ajnr.a9387","journal":"American Journal of Neuroradiology","n_participants":15,"pmid":"42055956","source_url":"https://pubmed.ncbi.nlm.nih.gov/42055956/","study_design":"longitudinal study","title":"PET-guided Assessment of Amyloid Clearance and Outcomes in a Real-World Cohort of Patients with Alzheimer Disease undergoing Anti-Amyloid Therapy","title_match":false,"year":2026},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/apoegenotype-modifies-the-association-of-meat-consumption-with-41434470","doi":"10.1002/alz70860_107412","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41434470","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12726212/","study_design":"longitudinal study","title":"APOE\u2010Genotype Modifies the Association of Meat Consumption with Cognitive Decline: Longitudinal Analyses of The Swedish National Study on Aging and Care, SNAC\u2010K","title_match":false,"year":2025},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/mind-diet-and-hippocampal-sclerosis-among-community-based-older-adults-40773193","doi":"10.1001/jamanetworkopen.2025.26089","journal":"JAMA Network Open","n_participants":300,"pmid":"40773193","source_url":"https://pubmed.ncbi.nlm.nih.gov/40773193/","study_design":"cohort study","title":"MIND Diet and Hippocampal Sclerosis Among Community-Based Older Adults","title_match":false,"year":2025},{"alzhub_score":26,"alzhub_url":"https://alzhub.org/study/privacion-del-sueno-y-melatonina-factores-que-influyen-en-la-fcc8b6d3","doi":"10.37811/cl_rcm.v9i5.20119","journal":"Ciencia Latina Revista Cient\u00edfica Multidisciplinar","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.37811/cl_rcm.v9i5.20119","study_design":null,"title":"Privaci\u00f3n del Sue\u00f1o y Melatonina Factores que Influyen en la Enfermedad de Alzheimer: Revisi\u00f3n Sistem\u00e1tica","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/alzheimer-related-individual-factors-modulate-effects-of-transcranial-41408121","doi":"10.1038/s41598-025-27612-7","journal":"Scientific Reports","n_participants":55,"pmid":"41408121","source_url":"https://pubmed.ncbi.nlm.nih.gov/41408121/","study_design":"longitudinal study","title":"Alzheimer-related individual factors modulate effects of transcranial direct current stimulation strength on white matter integrity in mild cognitive impairment","title_match":false,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/relationship-between-within-session-digital-motor-skill-acquisition-40273338","doi":"10.2196/67298","journal":"JMIR Aging","n_participants":null,"pmid":"40273338","source_url":"https://pubmed.ncbi.nlm.nih.gov/40273338/","study_design":null,"title":"Relationship Between Within-Session Digital Motor Skill Acquisition and Alzheimer Disease Risk Factors Among the MindCrowd Cohort: Cross-Sectional Descriptive Study","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/searching-for-responders-to-multidomain-dementia-prevention-in-late-39821948","doi":"10.1002/alz.14472","journal":"Alzheimer s & Dementia","n_participants":5205,"pmid":"39821948","source_url":"https://pubmed.ncbi.nlm.nih.gov/39821948/","study_design":null,"title":"Searching for responders to multidomain dementia prevention in late life: A pooled analysis of individual participant data from the MAPT and preDIVA trials","title_match":false,"year":2025},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-an-integrated-multidisciplinary-perspective-on-2448a12c","doi":"10.64483/202522763","journal":"Saudi Journal of Medicine and Public Health","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64483/202522763","study_design":"narrative review","title":"Alzheimer Disease: An Integrated Multidisciplinary Perspective on Pathophysiology, Diagnosis, Management, and Contemporary Therapeutic Advances for Pharmacists, Neurologists, Nurses, Health Information Professionals, and Healthcare Assistants","title_match":false,"year":2025},{"alzhub_score":28,"alzhub_url":"https://alzhub.org/study/impact-of-triplicated-dyrk1a-on-neurogenesis-and-intellectual-f226c855","doi":"10.14218/ge.2025.00051","journal":"Gene Expression","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.14218/ge.2025.00051","study_design":null,"title":"Impact of Triplicated DYRK1A on Neurogenesis and Intellectual Disability in Down Syndrome and Therapeutic Potential","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/realworld-eligibility-for-antiamyloid-treatment-in-a-tertiary-memory-40506692","doi":"10.1002/alz.70375","journal":"Alzheimer s & Dementia","n_participants":1309,"pmid":"40506692","source_url":"https://pubmed.ncbi.nlm.nih.gov/40506692/","study_design":null,"title":"\u201cReal\u2010world\u201d eligibility for anti\u2010amyloid treatment in a tertiary memory clinic setting","title_match":false,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/krankheitsmodifizierende-therapie-mit-lecanemab-bei-fruher-alzheimer-41052542","doi":"10.1055/a-2681-4558","journal":"Fortschritte der Neurologie \u00b7 Psychiatrie","n_participants":null,"pmid":"41052542","source_url":"https://pubmed.ncbi.nlm.nih.gov/41052542/","study_design":null,"title":"Krankheitsmodifizierende Therapie mit Lecanemab bei fr\u00fcher Alzheimer-Demenz","title_match":false,"year":2025},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/changes-of-a-cerebral-cavernous-malformation-associated-with-40584633","doi":"10.1212/cpj.0000000000200508","journal":"Neurology Clinical Practice","n_participants":null,"pmid":"40584633","source_url":"https://pubmed.ncbi.nlm.nih.gov/40584633/","study_design":null,"title":"Changes of a Cerebral Cavernous Malformation Associated With Lecanemab Therapy in a Patient With Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/clinical-practice-outcomes-with-lecanemab-for-alzheimer-disease-42746606","doi":"10.1212/wn9.0000000000000121","journal":"Neurology Open Access","n_participants":null,"pmid":"42746606","source_url":"https://pubmed.ncbi.nlm.nih.gov/42746606/","study_design":null,"title":"Clinical Practice Outcomes With Lecanemab for Alzheimer Disease","title_match":false,"year":2026},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/anti-amyloid-monoclonal-antibodies-and-amyloid-related-imaging-4ee39e2d","doi":"10.5281/zenodo.22310606","journal":"Zenodo (CERN European Organization for Nuclear Research)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.5281/zenodo.22310606","study_design":"narrative review","title":"Anti-Amyloid Monoclonal Antibodies and Amyloid-Related Imaging Abnormalities in Early Alzheimer Disease","title_match":false,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/anti-amyloid-monoclonal-antibodies-and-amyloid-related-imaging-95d6b60f","doi":"10.5281/zenodo.22310607","journal":"Zenodo (CERN European Organization for Nuclear Research)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.5281/zenodo.22310607","study_design":"narrative review","title":"Anti-Amyloid Monoclonal Antibodies and Amyloid-Related Imaging Abnormalities in Early Alzheimer Disease","title_match":false,"year":2026},{"alzhub_score":28,"alzhub_url":"https://alzhub.org/study/lecanemab-leqembi-25dfc5ad","doi":"10.51731/cjht.2026.1514","journal":"Canadian Journal of Health Technologies","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.51731/cjht.2026.1514","study_design":null,"title":"Lecanemab (Leqembi)","title_match":false,"year":2026},{"alzhub_score":28,"alzhub_url":"https://alzhub.org/study/recomendaciones-de-uso-de-donanemab-ef1b4e53","doi":"10.22379/anc.1993","journal":"Acta neurol\u00f3gica colombiana","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.22379/anc.1993","study_design":null,"title":"Recomendaciones de uso de donanemab","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/assessing-family-history-and-approaches-for-identifying-patients-with-40621734","doi":"10.1016/j.gim.2025.101517","journal":"Genetics in Medicine","n_participants":701,"pmid":"40621734","source_url":"https://pubmed.ncbi.nlm.nih.gov/40621734/","study_design":null,"title":"Assessing family history and approaches for identifying patients with dementia with diagnostically significant genetic findings","title_match":false,"year":2025},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/lecanemab-autorizado-para-tratamiento-del-alzheimer-en-pacientes-que-d2104574","doi":"10.63105/pam8","journal":"Panorama actual del medicamento","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.63105/pam8","study_design":null,"title":"Lecanemab autorizado para tratamiento del Alzh\u00e9imer en pacientes que tienen una o ninguna copia de ApoE4: una reacci\u00f3n adversa grave limita su uso","title_match":true,"year":2025},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/redefining-alzheimers-disease-through-modern-biotechnology-from-92541794","doi":"10.65035/w1y9ey43","journal":"Journal of medical & health sciences review.","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.65035/w1y9ey43","study_design":null,"title":"REDEFINING ALZHEIMER\u2019S DISEASE THROUGH MODERN BIOTECHNOLOGY; FROM MOLECULAR PATHOGENESIS TO INNOVATIVE THERAPEUTICS AND DIAGNOSTIC FRONTIERS","title_match":false,"year":2025},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/terapia-anti-amiloide-y-enfermedad-cerebrovascular-nuevos-retos-para-7db0e4e9","doi":"10.22379/anc.2188","journal":"Acta neurol\u00f3gica colombiana","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.22379/anc.2188","study_design":null,"title":"Terapia anti \u03b2-amiloide y enfermedad cerebrovascular: nuevos retos para la neurolog\u00eda vascular","title_match":false,"year":2026},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/alzheimers-disease-pathophysiology-current-and-emerging-therapeutic-411be862","doi":"10.18231/j.ctppc.39626.1776405949","journal":"Current Trends in Pharmacy and Pharmaceutical Chemistry","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.18231/j.ctppc.39626.1776405949","study_design":null,"title":"Alzheimer\u2019s disease: Pathophysiology, current and emerging therapeutic approaches for Alzheimer\u2019s disease","title_match":false,"year":2026},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/interplay-of-genetic-predisposition-plasma-metabolome-and-40855194","doi":"10.1038/s41591-025-03891-5","journal":"Nature Medicine","n_participants":null,"pmid":"40855194","source_url":"https://pubmed.ncbi.nlm.nih.gov/40855194/","study_design":null,"title":"Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function","title_match":false,"year":2025},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/hearing-loss-brain-structure-cognition-and-dementia-risk-in-the-41191359","doi":"10.1001/jamanetworkopen.2025.39209","journal":"JAMA Network Open","n_participants":1656,"pmid":"41191359","source_url":"https://pubmed.ncbi.nlm.nih.gov/41191359/","study_design":"cohort study","title":"Hearing Loss, Brain Structure, Cognition, and Dementia Risk in the Framingham Heart Study","title_match":false,"year":2025},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/risk-factors-associated-with-late-onset-epilepsy-in-dementia-and-mild-40227723","doi":"10.1001/jamaneurol.2025.0552","journal":"JAMA Neurology","n_participants":713,"pmid":"40227723","source_url":"https://pubmed.ncbi.nlm.nih.gov/40227723/","study_design":"longitudinal study","title":"Risk Factors Associated With Late-Onset Epilepsy in Dementia and Mild Cognitive Impairment","title_match":false,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/associations-between-the-eat-lancet-planetary-health-diet-and-40222839","doi":"10.1016/j.tjpad.2025.100166","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":25898,"pmid":"40222839","source_url":"https://pubmed.ncbi.nlm.nih.gov/40222839/","study_design":null,"title":"Associations between the EAT-Lancet planetary health diet and incident dementia","title_match":false,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/dementia-in-severe-schizophrenia-41920573","doi":"10.1001/jamapsychiatry.2026.0171","journal":"JAMA Psychiatry","n_participants":155,"pmid":"41920573","source_url":"https://pubmed.ncbi.nlm.nih.gov/41920573/","study_design":"cohort study","title":"Dementia in Severe Schizophrenia","title_match":false,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/neuroimaging-compendium-of-microglia-amyloid-tau-and-41288284","doi":"10.1097/wad.0000000000000707","journal":"Alzheimer Disease & Associated Disorders","n_participants":null,"pmid":"41288284","source_url":"https://pubmed.ncbi.nlm.nih.gov/41288284/","study_design":"longitudinal study","title":"Neuroimaging Compendium of Microglia, Amyloid, Tau, and Neurodegeneration Across Clinical Variants of Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/characterizing-the-olfaction-and-dementia-association-in-the-39988999","doi":"10.1002/alz.14613","journal":"Alzheimer s & Dementia","n_participants":4470,"pmid":"39988999","source_url":"https://pubmed.ncbi.nlm.nih.gov/39988999/","study_design":null,"title":"Characterizing the olfaction and dementia association in the community\u2010based ARIC study","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/population-intervention-models-of-racial-ethnic-disparities-in-41035086","doi":"10.1186/s13195-025-01866-9","journal":"Alzheimer s Research & Therapy","n_participants":null,"pmid":"41035086","source_url":"https://pubmed.ncbi.nlm.nih.gov/41035086/","study_design":null,"title":"Population intervention models of racial ethnic disparities in cognitive outcomes from cardiometabolic risk factors \u2013 HABS-HD","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/predictors-of-transition-from-mild-cognitive-impairment-to-normal-41301354","doi":"10.3390/bs15111552","journal":"Behavioral Sciences","n_participants":272,"pmid":"41301354","source_url":"https://pubmed.ncbi.nlm.nih.gov/41301354/","study_design":null,"title":"Predictors of Transition from Mild Cognitive Impairment to Normal Cognition and Dementia","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/impact-of-apoe4related-dementia-risk-in-underrepresented-groups-from-40501118","doi":"10.1002/alz.70245","journal":"Alzheimer s & Dementia","n_participants":9784,"pmid":"40501118","source_url":"https://pubmed.ncbi.nlm.nih.gov/40501118/","study_design":"longitudinal study","title":"Impact of APOE4\u2010related dementia risk in underrepresented groups from the All of Us research program","title_match":true,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/blood-dna-methylation-signature-for-incident-dementia-evidence-from-40133250","doi":"10.1002/alz.14496","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40133250","source_url":"https://pubmed.ncbi.nlm.nih.gov/40133250/","study_design":"meta-analysis","title":"Blood DNA methylation signature for incident dementia: Evidence from longitudinal cohorts","title_match":false,"year":2025},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/association-of-mediterranean-high-quality-and-anti-inflammatory-diet-40315790","doi":"10.1016/j.jnha.2025.100564","journal":"The journal of nutrition health & aging","n_participants":131209,"pmid":"40315790","source_url":"https://pubmed.ncbi.nlm.nih.gov/40315790/","study_design":null,"title":"Association of Mediterranean, high-quality, and anti-inflammatory diet with dementia in UK Biobank cohort","title_match":false,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/cardiovascular-kidney-metabolic-health-genetic-susceptibility-and-the-40784862","doi":"10.1016/j.tjpad.2025.100325","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":331731,"pmid":"40784862","source_url":"https://pubmed.ncbi.nlm.nih.gov/40784862/","study_design":"cohort study","title":"Cardiovascular-kidney-metabolic health, genetic susceptibility, and the risk of dementia: A prospective cohort study","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/type-2-diabetes-and-late-onset-alzheimers-disease-and-related-40129417","doi":"10.1177/13872877251326107","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"40129417","source_url":"https://pubmed.ncbi.nlm.nih.gov/40129417/","study_design":null,"title":"Type 2 diabetes and late-onset Alzheimer\u2019s disease and related dementia: A longitudinal cohort study integrating polygenic risk score","title_match":false,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/integrative-machine-learning-approach-to-risk-prediction-for-dementia-40864401","doi":"10.1007/s11357-025-01828-x","journal":"GeroScience","n_participants":2878,"pmid":"40864401","source_url":"https://pubmed.ncbi.nlm.nih.gov/40864401/","study_design":null,"title":"Integrative machine learning approach to risk prediction for dementia and Alzheimer\u2019s disease","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/machine-learning-models-for-dementia-screening-to-classify-brain-39838434","doi":"10.1186/s13195-024-01650-1","journal":"Alzheimer s Research & Therapy","n_participants":15,"pmid":"39838434","source_url":"https://pubmed.ncbi.nlm.nih.gov/39838434/","study_design":null,"title":"Machine learning models for dementia screening to classify brain amyloid positivity on positron emission tomography using blood markers and demographic characteristics: a retrospective observational study","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/association-between-plasma-metabolomic-profile-and-machine-40888555","doi":"10.1111/acel.70208","journal":"Aging Cell","n_participants":17770,"pmid":"40888555","source_url":"https://pubmed.ncbi.nlm.nih.gov/40888555/","study_design":null,"title":"Association Between Plasma Metabolomic Profile and Machine Learning\u2010Based Brain Age","title_match":false,"year":2025},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/association-of-rapid-eye-movement-sleep-latency-with-multimodal-39868572","doi":"10.1002/alz.14495","journal":"Alzheimer s & Dementia","n_participants":128,"pmid":"39868572","source_url":"https://pubmed.ncbi.nlm.nih.gov/39868572/","study_design":null,"title":"Association of rapid eye movement sleep latency with multimodal biomarkers of Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/bace1-as-an-early-biomarker-and-its-relevance-to-risk-factors-for-40706761","doi":"10.1016/j.brainresbull.2025.111475","journal":"Brain Research Bulletin","n_participants":null,"pmid":"40706761","source_url":"https://pubmed.ncbi.nlm.nih.gov/40706761/","study_design":null,"title":"BACE1 as an early biomarker and its relevance to risk factors for Alzheimer\u2019s disease","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/type-2-diabetes-mellitus-cognitive-performance-and-incident-dementia-41342355","doi":"10.1111/jnc.70306","journal":"Journal of Neurochemistry","n_participants":9943,"pmid":"41342355","source_url":"https://pubmed.ncbi.nlm.nih.gov/41342355/","study_design":null,"title":"Type 2 Diabetes Mellitus, Cognitive Performance, and Incident Dementia; Identifying Mediating Pathways and Biomarkers From the Plasma Proteome","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/early-detection-of-white-matter-integrity-changes-in-down-syndrome-89e62d72","doi":"10.1002/alz70856_106537","journal":"Alzheimer s & Dementia","n_participants":70,"pmid":null,"source_url":"https://doi.org/10.1002/alz70856_106537","study_design":null,"title":"Early Detection of White Matter Integrity Changes in Down Syndrome: The Promise of PSMD as a Sensitive Biomarker","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/early-detection-of-white-matter-integrity-changes-in-down-syndrome-41433511","doi":"10.1002/alz70862_109982","journal":"Alzheimer s & Dementia","n_participants":70,"pmid":"41433511","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12725398/","study_design":"cross-sectional","title":"Early Detection of White Matter Integrity Changes in Down Syndrome: The Promise of PSMD as a Sensitive Biomarker","title_match":false,"year":2025},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/correlating-antemortem-amyloid-pet-burden-postmortem-mri-volumes-with-41453185","doi":"10.1002/alz70856_103737","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41453185","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12742906/","study_design":null,"title":"Correlating antemortem amyloid PET burden, postmortem MRI volumes, with neuropathological measures: Insights from Down syndrome and Alzheimer's disease cohorts","title_match":false,"year":2025},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/the-effect-of-lewy-body-co-pathology-on-the-clinical-and-imaging-39888600","doi":"10.1093/brain/awaf037","journal":"Brain","n_participants":661,"pmid":"39888600","source_url":"https://pubmed.ncbi.nlm.nih.gov/39888600/","study_design":"longitudinal study","title":"The effect of Lewy body (co-)pathology on the clinical and imaging phenotype of amnestic patients","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-hsp90aa1-hspa4-and-stub1-chip-levels-in-alzheimer-40116694","doi":"10.1177/13872877251329540","journal":"Journal of Alzheimer s Disease","n_participants":90,"pmid":"40116694","source_url":"https://pubmed.ncbi.nlm.nih.gov/40116694/","study_design":null,"title":"Cerebrospinal fluid HSP90AA1, HSPA4, and STUB1/CHIP levels in Alzheimer's disease, mild cognitive impairment, and frontotemporal dementia","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/genomewide-association-analysis-identifies-apoe-as-a-mitophagy-40309932","doi":"10.1002/alz.70198","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40309932","source_url":"https://pubmed.ncbi.nlm.nih.gov/40309932/","study_design":null,"title":"Genome\u2010wide association analysis identifies APOE as a mitophagy modifier in Lewy body disease","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/clinical-and-neuropathological-associations-of-plasma-a42-a40-ptau217-39886325","doi":"10.1002/dad2.70078","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","n_participants":620,"pmid":"39886325","source_url":"https://pubmed.ncbi.nlm.nih.gov/39886325/","study_design":"longitudinal study","title":"Clinical and neuropathological associations of plasma A\u03b242/A\u03b240, p\u2010tau217 and neurofilament light in sporadic frontotemporal dementia spectrum disorders","title_match":false,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/genome-wide-association-study-of-neuropathological-features-in-lewy-40091616","doi":"10.1093/brain/awaf105","journal":"Brain","n_participants":980,"pmid":"40091616","source_url":"https://pubmed.ncbi.nlm.nih.gov/40091616/","study_design":null,"title":"Genome-wide association study of neuropathological features in Lewy body disease","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/allostatic-load-dynamics-alzheimer-s-disease-biomarkers-and-40606518","doi":"10.1002/dad2.70140","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","n_participants":385,"pmid":"40606518","source_url":"https://pubmed.ncbi.nlm.nih.gov/40606518/","study_design":null,"title":"Allostatic load dynamics, Alzheimer's disease biomarkers, and progression in individuals with mild cognitive impairment: findings from the Alzheimer's Disease Neuroimaging Initiative","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/comparison-of-deep-learning-and-traditional-machine-learning-models-40141072","doi":"10.3390/ijms26062428","journal":"International Journal of Molecular Sciences","n_participants":239,"pmid":"40141072","source_url":"https://pubmed.ncbi.nlm.nih.gov/40141072/","study_design":null,"title":"Comparison of Deep Learning and Traditional Machine Learning Models for Predicting Mild Cognitive Impairment Using Plasma Proteomic Biomarkers","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/taurelated-reduction-of-glucose-metabolism-in-mild-cognitive-39989007","doi":"10.1002/alz.14625","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"39989007","source_url":"https://pubmed.ncbi.nlm.nih.gov/39989007/","study_design":null,"title":"Tau\u2010related reduction of glucose metabolism in mild cognitive impairment occurs independently of APOE \u03b54 genotype and is influenced by A\u03b2","title_match":true,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/integrated-amyloid-neurodegeneration-and-vascular-biomarkers-estimate-42159446","doi":"10.1177/13872877261445623","journal":"Journal of Alzheimer s Disease","n_participants":58,"pmid":"42159446","source_url":"https://pubmed.ncbi.nlm.nih.gov/42159446/","study_design":"longitudinal study","title":"Integrated amyloid, neurodegeneration, and vascular biomarkers estimate the risk of dementia progression in mild cognitive impairment","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/comprehensive-anatomical-staging-predicts-clinical-progression-in-40564976","doi":"10.3390/ijms26125514","journal":"International Journal of Molecular Sciences","n_participants":504,"pmid":"40564976","source_url":"https://pubmed.ncbi.nlm.nih.gov/40564976/","study_design":null,"title":"Comprehensive Anatomical Staging Predicts Clinical Progression in Mild Cognitive Impairment: A Data-Driven Approach","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/a-longitudinal-analysis-of-t1-weighted-mri-features-associated-with-42115951","doi":"10.1186/s12880-026-02404-1","journal":"BMC Medical Imaging","n_participants":947,"pmid":"42115951","source_url":"https://pubmed.ncbi.nlm.nih.gov/42115951/","study_design":"longitudinal study","title":"A longitudinal analysis of T1-weighted MRI features associated with progression from mild cognitive impairment to Alzheimer\u2019s disease","title_match":false,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/aperiodic-eeg-signatures-unveiling-the-interplay-between-apoe-4-and-41583006","doi":"10.3389/fnagi.2025.1675330","journal":"Frontiers in Aging Neuroscience","n_participants":null,"pmid":"41583006","source_url":"https://pubmed.ncbi.nlm.nih.gov/41583006/","study_design":null,"title":"Aperiodic EEG signatures: unveiling the interplay between APOE \u03b54 and mild cognitive impairment subtypes","title_match":true,"year":2026},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/genetic-drivers-of-hippocampal-atrophy-highlight-the-role-of-apoe-41092763","doi":"10.1016/j.nicl.2025.103889","journal":"NeuroImage Clinical","n_participants":1051,"pmid":"41092763","source_url":"https://pubmed.ncbi.nlm.nih.gov/41092763/","study_design":"longitudinal study","title":"Genetic drivers of hippocampal atrophy highlight the role of APOE functional variants and AD polygenicity in Mild Cognitive Impairment","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/towards-the-development-of-a-management-protocol-for-subjective-41603334","doi":"10.1177/13872877261416117","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"41603334","source_url":"https://pubmed.ncbi.nlm.nih.gov/41603334/","study_design":null,"title":"Towards the development of a management protocol for subjective cognitive decline: Insights from a cross-sectional and longitudinal analysis of multimodal data from a memory clinic","title_match":false,"year":2026},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/conversion-to-mild-cognitive-impairment-and-alzheimers-disease-40227643","doi":"10.1177/08919887251335002","journal":"Journal of Geriatric Psychiatry and Neurology","n_participants":null,"pmid":"40227643","source_url":"https://pubmed.ncbi.nlm.nih.gov/40227643/","study_design":null,"title":"Conversion to Mild Cognitive Impairment and Alzheimer\u2019s Disease Dementia Related to Apathy, APOE Genotype and Antidepressant Use","title_match":false,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/sensitivity-comparison-of-longitudinal-cognitive-function-indicators-41866365","doi":"10.1038/s41598-026-44192-2","journal":"Scientific Reports","n_participants":596,"pmid":"41866365","source_url":"https://pubmed.ncbi.nlm.nih.gov/41866365/","study_design":"longitudinal study","title":"Sensitivity comparison of longitudinal cognitive function indicators of Alzheimer\u2019s disease after mild cognitive impairment: a prospective cohort study","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/nonpharmacological-multicomponent-intervention-for-mild-cognitive-12e6dfb4","doi":"10.1186/s40814-026-01871-1","journal":"PubMed Central","n_participants":40,"pmid":null,"source_url":"https://doi.org/10.1186/s40814-026-01871-1","study_design":null,"title":"Nonpharmacological multicomponent intervention for mild cognitive impairment with a family-patient approach: protocol for the pilot clinical trial\u2014INTERCOG study","title_match":false,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/sex-specific-effects-of-apolipoprotein-e-4-genotype-on-longitudinal-39924830","doi":"10.1177/13872877241313066","journal":"Journal of Alzheimer s Disease","n_participants":73,"pmid":"39924830","source_url":"https://pubmed.ncbi.nlm.nih.gov/39924830/","study_design":"longitudinal study","title":"Sex-specific effects of apolipoprotein E \u03b54 genotype on longitudinal hippocampal atrophy in amnestic mild cognitive impairment over a 2-year evaluation period","title_match":true,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/the-connection-between-autophagy-and-alzheimers-disease-41123674","doi":"10.1007/s00011-025-02118-0","journal":"Inflammation Research","n_participants":null,"pmid":"41123674","source_url":"https://pubmed.ncbi.nlm.nih.gov/41123674/","study_design":null,"title":"The connection between autophagy and Alzheimer\u2019s disease","title_match":false,"year":2025},{"alzhub_score":25,"alzhub_url":"https://alzhub.org/study/enfermedad-de-alzheimer-en-la-mujer-76f633af","doi":"10.36104/amc.2025.4956","journal":"Acta M\u00e9dica Colombiana","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.36104/amc.2025.4956","study_design":null,"title":"Enfermedad de Alzheimer en la mujer","title_match":false,"year":2025},{"alzhub_score":27,"alzhub_url":"https://alzhub.org/study/transformative-approaches-to-alzheimer-disease-treatment-current-b059f7db","doi":"10.52783/cana.v32.5141","journal":"Communications on Applied Nonlinear Analysis","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.52783/cana.v32.5141","study_design":null,"title":"\"Transformative Approaches to Alzheimer Disease Treatment: Current Progress and Future Direction\u201d","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/genetic-insights-into-alzheimer-s-disease-from-cuban-american-studies-41442102","doi":"10.1002/alz70855_106251","journal":"Alzheimer s & Dementia","n_participants":239,"pmid":"41442102","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12731481/","study_design":null,"title":"Genetic Insights into Alzheimer's Disease from Cuban American Studies","title_match":false,"year":2025},{"alzhub_score":28,"alzhub_url":"https://alzhub.org/study/crisprcas9mediated-genetic-correction-for-alzheimer-s-disease-a-8dfd48d1","doi":"10.5281/zenodo.18032007","journal":"Zenodo (CERN European Organization for Nuclear Research)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.5281/zenodo.18032007","study_design":null,"title":"CRISPR\u2013Cas9\u2013Mediated Genetic Correction for Alzheimer's Disease A Hypothetical Therapeutic Framework","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/crisprcas9mediated-genetic-correction-for-alzheimer-s-disease-a-a93d1dcb","doi":"10.5281/zenodo.18032008","journal":"Zenodo (CERN European Organization for Nuclear Research)","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.5281/zenodo.18032008","study_design":null,"title":"CRISPR\u2013Cas9\u2013Mediated Genetic Correction for Alzheimer's Disease A Hypothetical Therapeutic Framework","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/baseline-participant-characteristics-in-the-diantu001-trial-41450326","doi":"10.1002/alz70859_105299","journal":"Alzheimer s & Dementia","n_participants":243,"pmid":"41450326","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12741730/","study_design":null,"title":"Baseline Participant Characteristics in the DIAN\u2010TU\u2010001 Trial","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/mosaic-loss-of-chromosome-y-and-plasma-a42-ptau181-ratio-as-dff7ac55","doi":"10.1002/alz70856_106620","journal":"Alzheimer s & Dementia","n_participants":30,"pmid":null,"source_url":"https://doi.org/10.1002/alz70856_106620","study_design":null,"title":"Mosaic Loss of Chromosome Y and Plasma A\u03b242/p\u2010tau181 Ratio as Biomarkers for Alzheimer's Disease in the Midwestern Amish","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-seed-aggregation-assay-and-alzheimer-biomarkers-41511749","doi":"10.1002/alz70856_107531","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41511749","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12787306/","study_design":"longitudinal study","title":"Cerebrospinal fluid seed aggregation assay and Alzheimer biomarkers in a Dementia with Lewy Body cohort","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/contribution-of-genetic-and-lifestyle-factors-in-resistance-and-41447325","doi":"10.1002/alz70856_101525","journal":"Alzheimer s & Dementia","n_participants":529,"pmid":"41447325","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12739984/","study_design":"longitudinal study","title":"Contribution of genetic and lifestyle factors in resistance\u2010 and resilience\u2010related variability in longitudinal pathologic and neurodegeneration trajectory in Dominantly Inherited Alzheimer's Disease","title_match":false,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/a-positive-tau-biomarker-negative-cognitive-impairment-is-associated-256d8475","doi":"10.1002/alz70856_104812","journal":"Alzheimer s & Dementia","n_participants":77,"pmid":null,"source_url":"https://doi.org/10.1002/alz70856_104812","study_design":null,"title":"A\u03b2 positive, tau biomarker negative cognitive impairment is associated with significant non\u2010Alzheimer's disease neuropathologies","title_match":false,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/at-n-biomarkers-across-modalities-in-the-pathways-between-41434330","doi":"10.1002/alz70861_108709","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41434330","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12725982/","study_design":null,"title":"AT(N) Biomarkers Across Modalities in the Pathways Between Multimorbidity and Cognition","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/data-driven-characterization-of-distinct-cognitive-subtypes-in-40346094","doi":"10.1038/s41531-025-00970-9","journal":"npj Parkinson s Disease","n_participants":50,"pmid":"40346094","source_url":"https://pubmed.ncbi.nlm.nih.gov/40346094/","study_design":null,"title":"Data-driven characterization of distinct cognitive subtypes in Parkinson\u2019s disease dementia","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/elevated-gonadotropins-and-risk-of-dementia-in-chinese-adults-aged-41180813","doi":"10.3389/fnagi.2025.1651723","journal":"Frontiers in Aging Neuroscience","n_participants":509,"pmid":"41180813","source_url":"https://pubmed.ncbi.nlm.nih.gov/41180813/","study_design":"cross-sectional","title":"Elevated gonadotropins and risk of dementia in Chinese adults aged over 80: a cross-sectional study","title_match":false,"year":2025},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/clinical-efficacy-safety-and-imaging-effects-of-oral-41015981","doi":"10.1007/s40265-025-02250-5","journal":"Drugs","n_participants":320,"pmid":"41015981","source_url":"https://pubmed.ncbi.nlm.nih.gov/41015981/","study_design":null,"title":"Clinical Efficacy, Safety and Imaging Effects of Oral Valiltramiprosate in APOE\u03b54/\u03b54 Homozygotes with Early Alzheimer\u2019s Disease: Results of the Phase III, Randomized, Double-Blind, Placebo-Controlled, 78-Week APOLLOE4 Trial","title_match":true,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/apoe-genotype-age-and-cognitive-decline-in-old-chinese-individuals-39814697","doi":"10.1002/gps.70045","journal":"International Journal of Geriatric Psychiatry","n_participants":null,"pmid":"39814697","source_url":"https://pubmed.ncbi.nlm.nih.gov/39814697/","study_design":null,"title":"ApoE Genotype, Age, and Cognitive Decline in Old Chinese Individuals Without Dementia: A Population\u2010Based Study With Five\u2010Year Follow\u2010Up","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/associations-of-plasma-ptau231-with-serial-position-recall-40986437","doi":"10.1111/jnp.70012","journal":"Journal of Neuropsychology","n_participants":327,"pmid":"40986437","source_url":"https://pubmed.ncbi.nlm.nih.gov/40986437/","study_design":null,"title":"Associations of plasma p\u2010tau231 with serial position recall performance in free\u2010of\u2010dementia individuals","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/livermetabolic-stress-apolipoprotein-e-4-and-cognition-and-amyloid-41890209","doi":"10.3389/fnagi.2026.1773977","journal":"Frontiers in Aging Neuroscience","n_participants":507,"pmid":"41890209","source_url":"https://pubmed.ncbi.nlm.nih.gov/41890209/","study_design":"longitudinal study","title":"Liver\u2013metabolic stress, apolipoprotein E \u03b54, and cognition and amyloid burden: findings from the dementia platform Korea trial-ready registry","title_match":true,"year":2026},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/alzheimers-disease-polygenic-risks-association-with-all-cause-40588577","doi":"10.1007/s11357-025-01724-4","journal":"GeroScience","n_participants":249,"pmid":"40588577","source_url":"https://pubmed.ncbi.nlm.nih.gov/40588577/","study_design":null,"title":"Alzheimer\u2019s disease polygenic risk\u2019s association with all-cause dementia through the plasma metabolome in the UK Biobank study","title_match":false,"year":2025},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/age-at-diabetes-diagnosis-genetic-susceptibility-and-dementia-risk-a-5709812f","doi":"10.1016/j.medp.2025.100111","journal":"Medicine Plus","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1016/j.medp.2025.100111","study_design":null,"title":"Age at diabetes diagnosis, genetic susceptibility and dementia risk: a prospective study of 13,126 participants from the UK Biobank","title_match":false,"year":2025},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/objective-physical-activity-and-alzheimer-s-disease-burden-in-the-40965463","doi":"10.1002/alz.70655","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"40965463","source_url":"https://pubmed.ncbi.nlm.nih.gov/40965463/","study_design":null,"title":"Objective physical activity and Alzheimer's disease burden in the population\u2010based Rotterdam Study","title_match":false,"year":2025},{"alzhub_score":33,"alzhub_url":"https://alzhub.org/study/the-bidirectional-association-of-epilepsy-with-alzheimer-s-disease-42135610","doi":"10.1177/13872877261450962","journal":"Journal of Alzheimer s Disease","n_participants":null,"pmid":"42135610","source_url":"https://pubmed.ncbi.nlm.nih.gov/42135610/","study_design":null,"title":"The bidirectional association of epilepsy with Alzheimer's disease and other neurodegenerative dementias: A longitudinal observational study on the UK Biobank","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/imaging-genetics-based-dementia-risk-prediction-using-deep-survival-41041540","doi":"10.1038/s41598-026-47047-y","journal":"Scientific Reports","n_participants":3521,"pmid":"41041540","source_url":"https://pubmed.ncbi.nlm.nih.gov/41041540/","study_design":"post-hoc analysis","title":"Imaging-genetics-based dementia risk prediction using deep survival neural networks in the Rotterdam Study","title_match":false,"year":2026},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/crosssectional-study-of-plasma-phosphorylated-tau-217-in-persons-40352683","doi":"10.1002/dad2.70107","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","n_participants":697,"pmid":"40352683","source_url":"https://pubmed.ncbi.nlm.nih.gov/40352683/","study_design":null,"title":"Cross\u2010sectional study of plasma phosphorylated tau 217 in persons without dementia","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/mediation-of-the-association-between-apoe-4-genotype-cognition-and-40344552","doi":"10.1212/wnl.0000000000213679","journal":"Neurology","n_participants":null,"pmid":"40344552","source_url":"https://pubmed.ncbi.nlm.nih.gov/40344552/","study_design":null,"title":"Mediation of the Association Between APOE \u03b54 Genotype, Cognition, and Dementia by Neuropathology Imaging Markers in the Rotterdam Study","title_match":true,"year":2025},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/common-neuropathologic-change-drivers-of-hippocampal-sclerosis-of-40323260","doi":"10.1093/brain/awaf158","journal":"Brain","n_participants":1933,"pmid":"40323260","source_url":"https://pubmed.ncbi.nlm.nih.gov/40323260/","study_design":null,"title":"Common neuropathologic change drivers of hippocampal sclerosis of ageing","title_match":false,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/cerebral-amyloid-angiopathy-and-risk-of-dementia-in-patients-with-42081781","doi":"10.1212/wnl.0000000000218009","journal":"Neurology","n_participants":307,"pmid":"42081781","source_url":"https://pubmed.ncbi.nlm.nih.gov/42081781/","study_design":"prospective cohort","title":"Cerebral Amyloid Angiopathy and Risk of Dementia in Patients With Cognitive Complaint","title_match":false,"year":2026},{"alzhub_score":31,"alzhub_url":"https://alzhub.org/study/tdp43-and-apoe-a-complex-interaction-41443591","doi":"10.1002/alz70855_105886","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41443591","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12737955/","study_design":null,"title":"TDP\u201043 and APOE: A complex interaction","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/datadriven-discovery-of-midlife-cardiometabolic-profile-associated-40045775","doi":"10.1111/dom.16292","journal":"Diabetes Obesity and Metabolism","n_participants":249,"pmid":"40045775","source_url":"https://pubmed.ncbi.nlm.nih.gov/40045775/","study_design":null,"title":"Data\u2010driven discovery of midlife cardiometabolic profile associated with incident early\u2010onset and late\u2010onset dementia","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/human-ipsc-derived-apoe4-4-alzheimer-s-disease-astrocytes-exhibit-a-41388301","doi":"10.1186/s12974-025-03607-z","journal":"Journal of Neuroinflammation","n_participants":null,"pmid":"41388301","source_url":"https://pubmed.ncbi.nlm.nih.gov/41388301/","study_design":null,"title":"Human iPSC-derived APOE4/4 Alzheimer\u00b4s disease astrocytes exhibit a senescent and pro-inflammatory state that compromises neuronal support","title_match":true,"year":2025},{"alzhub_score":49,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-of-amyloid-tau-neuroinflammation-in-alzheimers-40314736","doi":"10.1007/s00406-025-02013-z","journal":"European Archives of Psychiatry and Clinical Neuroscience","n_participants":27,"pmid":"40314736","source_url":"https://pubmed.ncbi.nlm.nih.gov/40314736/","study_design":null,"title":"Plasma biomarkers of amyloid, tau & neuroinflammation in Alzheimer\u2019s disease and corticobasal syndrome","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/the-biological-intersection-between-chemotherapy-related-cognitive-39863251","doi":"10.1016/j.ajpath.2024.12.013","journal":"American Journal Of Pathology","n_participants":null,"pmid":"39863251","source_url":"https://pubmed.ncbi.nlm.nih.gov/39863251/","study_design":null,"title":"The Biological Intersection Between Chemotherapy-Related Cognitive Impairment and Alzheimer Disease","title_match":false,"year":2025},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/navigation-between-alzheimers-disease-ad-and-its-various-40943177","doi":"10.3390/ijms26178253","journal":"International Journal of Molecular Sciences","n_participants":null,"pmid":"40943177","source_url":"https://pubmed.ncbi.nlm.nih.gov/40943177/","study_design":null,"title":"Navigation Between Alzheimer\u2019s Disease (AD) and Its Various Pathophysiological Trajectories: The Pathogenic Link to Neuroimmunology\u2014Genetics and Neuroinflammation","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/convergence-of-neuroinflammation-across-major-neurotropic-viral-42215997","doi":"10.1186/s12974-026-03876-2","journal":"Journal of Neuroinflammation","n_participants":null,"pmid":"42215997","source_url":"https://pubmed.ncbi.nlm.nih.gov/42215997/","study_design":null,"title":"Convergence of neuroinflammation across major neurotropic viral exposomes in AD and ADRD","title_match":false,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/the-association-of-alzheimer-s-disease-and-related-dementias-41476029","doi":"10.1002/alz.71007","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"41476029","source_url":"https://pubmed.ncbi.nlm.nih.gov/41476029/","study_design":"cross-sectional","title":"The association of Alzheimer's disease and related dementias blood\u2010based biomarkers with depressive symptoms","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/pathological-mechanisms-and-treatment-progression-of-alzheimers-40660381","doi":"10.1186/s40001-025-02886-9","journal":"European journal of medical research","n_participants":null,"pmid":"40660381","source_url":"https://pubmed.ncbi.nlm.nih.gov/40660381/","study_design":null,"title":"Pathological mechanisms and treatment progression of Alzheimer\u2019s disease","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/apoe-calypse-tau-apoetau-synergy-in-alzheimers-disease-40856646","doi":"10.1084/jem.20250965","journal":"The Journal of Experimental Medicine","n_participants":null,"pmid":"40856646","source_url":"https://pubmed.ncbi.nlm.nih.gov/40856646/","study_design":null,"title":"ApoE-calypse tau: ApoE\u2013tau synergy in Alzheimer\u2019s disease","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/multi-functional-role-of-apolipoprotein-e-in-neurodegenerative-39944166","doi":"10.3389/fnagi.2025.1535280","journal":"Frontiers in Aging Neuroscience","n_participants":null,"pmid":"39944166","source_url":"https://pubmed.ncbi.nlm.nih.gov/39944166/","study_design":null,"title":"Multi-functional role of apolipoprotein E in neurodegenerative diseases","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/organ-specific-proteomic-aging-clocks-predict-disease-and-longevity-41299092","doi":"10.1038/s43587-025-01016-8","journal":"Nature Aging","n_participants":43616,"pmid":"41299092","source_url":"https://pubmed.ncbi.nlm.nih.gov/41299092/","study_design":null,"title":"Organ-specific proteomic aging clocks predict disease and longevity across diverse populations","title_match":false,"year":2025},{"alzhub_score":34,"alzhub_url":"https://alzhub.org/study/temporal-progression-of-auditory-brainstem-dysfunction-and-behavioral-42660657","doi":"10.1523/jneurosci.0511-26.2026","journal":"Journal of Neuroscience","n_participants":null,"pmid":"42660657","source_url":"https://pubmed.ncbi.nlm.nih.gov/42660657/","study_design":null,"title":"Temporal progression of auditory brainstem dysfunction and behavioral phenotypes in mouse models of tauopathy","title_match":false,"year":2026},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/comprehensive-metabolomics-profiling-reveals-novel-biomarkers-and-41229615","doi":"10.1093/braincomms/fcaf410","journal":"Brain Communications","n_participants":25,"pmid":"41229615","source_url":"https://pubmed.ncbi.nlm.nih.gov/41229615/","study_design":"cross-sectional","title":"Comprehensive metabolomics profiling reveals novel biomarkers and pathways for early detection of Alzheimer\u2019s disease","title_match":false,"year":2025},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/associations-of-klotho-vs-heterozygosity-and-klotho-protein-with-40112321","doi":"10.1177/13872877251326199","journal":"Journal of Alzheimer s Disease","n_participants":223,"pmid":"40112321","source_url":"https://pubmed.ncbi.nlm.nih.gov/40112321/","study_design":null,"title":"Associations of KLOTHO-VS heterozygosity and \u03b1-Klotho protein with cerebrospinal fluid Alzheimer's disease biomarkers","title_match":false,"year":2025},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/the-long-term-neuroprotective-effect-of-mind-and-mediterranean-diet-40993193","doi":"10.1038/s41598-025-17055-5","journal":"Scientific Reports","n_participants":1500,"pmid":"40993193","source_url":"https://pubmed.ncbi.nlm.nih.gov/40993193/","study_design":"cohort study","title":"The long-term neuroprotective effect of MIND and Mediterranean diet on patients with Alzheimer\u2019s disease","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/multidomain-interventions-for-preventing-cognitive-decline-in-older-40546712","doi":"10.1016/j.jarlif.2025.100016","journal":"Journal of Aging Research and Lifestyle","n_participants":531,"pmid":"40546712","source_url":"https://pubmed.ncbi.nlm.nih.gov/40546712/","study_design":null,"title":"Multidomain interventions for preventing cognitive decline in older adults with type 2 diabetes and mild cognitive impairment: Secondary analysis of the J-MINT","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/south-korean-study-to-prevent-cognitive-impairment-and-protect-brain-39840755","doi":"10.1002/alz.14517","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":"39840755","source_url":"https://pubmed.ncbi.nlm.nih.gov/39840755/","study_design":"randomized controlled trial","title":"South Korean study to prevent cognitive impairment and protect brain health through multidomain interventions via face\u2010to\u2010face and video communication platforms in mild cognitive impairment (SUPERBRAIN\u2010MEET): A randomized controlled trial","title_match":false,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/the-role-of-the-mediterranean-diet-in-the-treatment-of-cognitive-40896190","doi":"10.3389/fnut.2025.1654684","journal":"Frontiers in Nutrition","n_participants":250000,"pmid":"40896190","source_url":"https://pubmed.ncbi.nlm.nih.gov/40896190/","study_design":"meta-analysis","title":"The role of the Mediterranean diet in the treatment of cognitive dysfunction in patients with type 2 diabetes mellitus","title_match":false,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/baseline-predictors-of-neurophysiological-response-to-combined-41781884","doi":"10.1186/s12877-026-07270-8","journal":"BMC Geriatrics","n_participants":21,"pmid":"41781884","source_url":"https://pubmed.ncbi.nlm.nih.gov/41781884/","study_design":"randomized controlled trial","title":"Baseline predictors of neurophysiological response to combined physical and cognitive training in older adults with subjective cognitive decline","title_match":false,"year":2026},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-executive-function-and-falls-across-cognitive-status-40875685","doi":"10.1159/000548084","journal":"Dementia and Geriatric Cognitive Disorders","n_participants":486,"pmid":"40875685","source_url":"https://pubmed.ncbi.nlm.nih.gov/40875685/","study_design":"cross-sectional","title":"Apolipoprotein E, Executive Function, and Falls across Cognitive Status: A Cross-Sectional Study","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/the-genetic-architecture-of-postoperative-delirium-after-major-41770756","doi":"10.1371/journal.pmed.1004963","journal":"PLoS Medicine","n_participants":null,"pmid":"41770756","source_url":"https://pubmed.ncbi.nlm.nih.gov/41770756/","study_design":"case-control study","title":"The genetic architecture of postoperative delirium after major surgery and its relationship with nonpostoperative neurocognitive conditions: A genome-wide association study","title_match":false,"year":2026},{"alzhub_score":42,"alzhub_url":"https://alzhub.org/study/unifying-vascular-injury-and-neurodegeneration-a-mechanistic-40913504","doi":"10.1111/ejn.70246","journal":"European Journal of Neuroscience","n_participants":null,"pmid":"40913504","source_url":"https://pubmed.ncbi.nlm.nih.gov/40913504/","study_design":null,"title":"Unifying Vascular Injury and Neurodegeneration: A Mechanistic Continuum in Cerebral Small Vessel Disease and Dementia","title_match":false,"year":2025},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/white-matter-hyperintensity-burden-predicts-domain-specific-cognitive-41290806","doi":"10.1038/s41598-025-25694-x","journal":"Scientific Reports","n_participants":158,"pmid":"41290806","source_url":"https://pubmed.ncbi.nlm.nih.gov/41290806/","study_design":"cross-sectional","title":"White matter hyperintensity burden predicts domain-specific cognitive decline across the Alzheimer\u2019s disease continuum","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/endothelial-progenitor-cells-and-cerebral-small-vessel-disease-in-40034682","doi":"10.1016/j.cccb.2025.100378","journal":"Cerebral Circulation - Cognition and Behavior","n_participants":109,"pmid":"40034682","source_url":"https://pubmed.ncbi.nlm.nih.gov/40034682/","study_design":null,"title":"Endothelial progenitor cells and cerebral small vessel disease in APOE4 carriers","title_match":true,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/association-of-increase-in-white-matter-hyperintensity-volume-with-40829101","doi":"10.1212/wnl.0000000000213975","journal":"Neurology","n_participants":null,"pmid":"40829101","source_url":"https://pubmed.ncbi.nlm.nih.gov/40829101/","study_design":null,"title":"Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/additive-effects-of-white-matter-hyperintensity-and-apoe-4-status-on-41267647","doi":"10.1002/ana.78103","journal":"Annals of Neurology","n_participants":1736,"pmid":"41267647","source_url":"https://pubmed.ncbi.nlm.nih.gov/41267647/","study_design":"cohort study","title":"Additive Effects of White Matter Hyperintensity and APOE \u03b54 Status on Risk of Incident Dementia in Two Large Longitudinal Cohorts","title_match":true,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/cerebral-small-vessel-disease-burden-relates-to-cognitive-decline-via-41958244","doi":"10.1177/0271678x261437577","journal":"Journal of Cerebral Blood Flow & Metabolism","n_participants":1026,"pmid":"41958244","source_url":"https://pubmed.ncbi.nlm.nih.gov/41958244/","study_design":"cross-sectional","title":"Cerebral small vessel disease burden relates to cognitive decline via impaired amyloid clearance in the general population","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/glymphatic-dysfunction-associates-with-regional-white-matter-42411051","doi":"10.1017/s0033291726105005","journal":"Psychological Medicine","n_participants":216,"pmid":"42411051","source_url":"https://pubmed.ncbi.nlm.nih.gov/42411051/","study_design":null,"title":"Glymphatic dysfunction associates with regional white matter hyperintensities and plasma amyloid-\u03b2 burden across the Alzheimer\u2019s disease continuum","title_match":false,"year":2026},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/associations-of-modifiable-and-non-modifiable-risk-factors-with-41478835","doi":"10.1016/j.tjpad.2025.100448","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":494,"pmid":"41478835","source_url":"https://pubmed.ncbi.nlm.nih.gov/41478835/","study_design":"longitudinal study","title":"Associations of modifiable and non-modifiable risk factors with longitudinal white matter hyperintensities, amyloid-\u03b2 and tau - a prospective cohort study","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/plasma-inflammatory-biomarker-associations-with-alzheimers-disease-0c982ec3","doi":"10.64898/2026.08.12.26360207","journal":"medRxiv (preprint)","n_participants":261,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.12.26360207","study_design":"cross-sectional","title":"Plasma inflammatory biomarker associations with Alzheimers disease clinical stage and CSF biomarkers: evaluation of sex effects","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/predicting-conversion-from-scd-to-mci-a-machine-learning-study-13d655ad","doi":"10.64898/2026.09.04.26362240","journal":"medRxiv (preprint)","n_participants":1352,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.04.26362240","study_design":"longitudinal study","title":"Predicting Conversion from SCD to MCI: A Machine Learning Study","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/associations-of-menopause-hormone-therapy-with-late-life-cognition-e370555c","doi":"10.64898/2026.09.16.26363120","journal":"medRxiv (preprint)","n_participants":8741,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.16.26363120","study_design":null,"title":"Associations of menopause hormone therapy with late-life cognition and brain health vary by formulation and APOE\u03b54 presence","title_match":true,"year":2026},{"alzhub_score":37,"alzhub_url":"https://alzhub.org/study/real-world-safety-and-implementation-challenges-of-lecanemab-therapy-42449395","doi":"10.1186/s13195-026-02141-1","journal":"Alzheimer's research & therapy","n_participants":112,"pmid":"42449395","source_url":"https://pubmed.ncbi.nlm.nih.gov/42449395/","study_design":null,"title":"Real-world safety and implementation challenges of lecanemab therapy for Alzheimer's disease in South Korea: a single-center experience","title_match":false,"year":2026},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/genetic-validation-of-abi3-p-ser209phe-variant-and-its-effects-on-41709289","doi":"10.1186/s13195-026-01984-y","journal":"Alzheimer's research & therapy","n_participants":500000,"pmid":"41709289","source_url":"https://pubmed.ncbi.nlm.nih.gov/41709289/","study_design":null,"title":"Genetic validation of ABI3 p.Ser209Phe variant and its effects on early brain pathology in asymptomatic elderly individuals","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/association-of-neighborhood-deprivation-with-alzheimer-s-disease-42145634","doi":"10.64898/2026.05.05.26352370","journal":"medRxiv : the preprint server for health sciences","n_participants":null,"pmid":"42145634","source_url":"https://pubmed.ncbi.nlm.nih.gov/42145634/","study_design":null,"title":"Association of neighborhood deprivation with Alzheimer's Disease pathology, brain structure, and cognition by race and ethnicity, sex, and APOE \u03b54 status","title_match":true,"year":2026},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/neighborhood-socioeconomic-deprivation-is-associated-with-worse-41674810","doi":"10.21203/rs.3.rs-8546338/v1","journal":"NPJ dementia","n_participants":1110,"pmid":"41674810","source_url":"https://pubmed.ncbi.nlm.nih.gov/41674810/","study_design":null,"title":"Neighborhood Socioeconomic Deprivation is Associated with Worse Cognitive Performance and in vivo Amyloid Accumulation","title_match":false,"year":2026},{"alzhub_score":35,"alzhub_url":"https://alzhub.org/study/the-association-between-neighborhood-deprivation-and-dna-methylation-38663907","doi":"10.18632/aging.205764","journal":"Aging","n_participants":null,"pmid":"38663907","source_url":"https://pubmed.ncbi.nlm.nih.gov/38663907/","study_design":null,"title":"The association between neighborhood deprivation and DNA methylation in an autopsy cohort","title_match":false,"year":2024},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/gene-dose-of-apolipoprotein-e-type-4-allele-and-the-risk-of-alzheimer-8346443","doi":"10.1126/science.8346443","journal":"Science","n_participants":null,"pmid":"8346443","source_url":"https://pubmed.ncbi.nlm.nih.gov/8346443/","study_design":null,"title":"Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families","title_match":false,"year":1993},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/association-of-apolipoprotein-e-allele-4-with-lateonset-familial-and-8350998","doi":"10.1212/wnl.43.8.1467","journal":"Neurology","n_participants":null,"pmid":"8350998","source_url":"https://pubmed.ncbi.nlm.nih.gov/8350998/","study_design":null,"title":"Association of apolipoprotein E allele \u03f54 with late\u2010onset familial and sporadic Alzheimer's disease","title_match":true,"year":1993},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/the-amyloid-hypothesis-of-alzheimer-s-disease-at-25-years-27025652","doi":"10.15252/emmm.201606210","journal":"EMBO Molecular Medicine","n_participants":null,"pmid":"27025652","source_url":"https://pubmed.ncbi.nlm.nih.gov/27025652/","study_design":null,"title":"The amyloid hypothesis of Alzheimer's disease at 25 years","title_match":false,"year":2016},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/amyloid-imaging-results-from-the-australian-imaging-biomarkers-and-20472326","doi":"10.1016/j.neurobiolaging.2010.04.007","journal":"Neurobiology of Aging","n_participants":null,"pmid":"20472326","source_url":"https://pubmed.ncbi.nlm.nih.gov/20472326/","study_design":null,"title":"Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging","title_match":false,"year":2010},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/inflammatory-biomarkers-predict-domain-specific-cognitive-decline-in-27522059","doi":"10.1093/gerona/glw155","journal":"The journals of gerontology. Series A, Biological sciences and medical sciences","n_participants":1159,"pmid":"27522059","source_url":"https://pubmed.ncbi.nlm.nih.gov/27522059/","study_design":"randomized controlled trial","title":"Inflammatory Biomarkers Predict Domain-Specific Cognitive Decline in Older Adults","title_match":false,"year":2017},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/systematic-review-of-genetic-association-studies-in-people-with-lewy-31898332","doi":"10.1002/gps.5260","journal":"International journal of geriatric psychiatry","n_participants":null,"pmid":"31898332","source_url":"https://pubmed.ncbi.nlm.nih.gov/31898332/","study_design":"systematic review","title":"Systematic review of genetic association studies in people with Lewy body dementia","title_match":false,"year":2020},{"alzhub_score":65,"alzhub_url":"https://alzhub.org/study/the-rare-trem2-r47h-variant-exerts-only-a-modest-effect-on-alzheimer-25186855","doi":"10.1212/wnl.0000000000000855","journal":"Neurology","n_participants":null,"pmid":"25186855","source_url":"https://pubmed.ncbi.nlm.nih.gov/25186855/","study_design":"meta-analysis","title":"The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk","title_match":false,"year":2014},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/interaction-between-variants-in-clu-and-ms4a4e-modulates-alzheimer-s-26449541","doi":"10.1016/j.jalz.2015.08.163","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"26449541","source_url":"https://pubmed.ncbi.nlm.nih.gov/26449541/","study_design":"meta-analysis","title":"Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk","title_match":false,"year":2016},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-genotype-and-deposits-of-abeta40-and-abeta42-in-9678319","doi":"10.1001/archneur.55.7.1001","journal":"Archives of neurology","n_participants":null,"pmid":"9678319","source_url":"https://pubmed.ncbi.nlm.nih.gov/9678319/","study_design":"clinical trial","title":"Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease","title_match":false,"year":1998},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-effect-of-apoe-4-on-alzheimer-s-disease-fluid-biomarkers-a-cross-39749650","doi":"10.1111/cns.70202","journal":"CNS neuroscience & therapeutics","n_participants":575,"pmid":"39749650","source_url":"https://pubmed.ncbi.nlm.nih.gov/39749650/","study_design":null,"title":"The Effect of APOE \u03b54 on Alzheimer's Disease Fluid Biomarkers: A Cross-Sectional Study Based on the COAST","title_match":true,"year":2025},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/chf5074-reduces-biomarkers-of-neuroinflammation-in-patients-with-mild-23968157","doi":"10.2174/13892037113149990144","journal":"Current Alzheimer research","n_participants":null,"pmid":"23968157","source_url":"https://pubmed.ncbi.nlm.nih.gov/23968157/","study_design":"randomized controlled trial","title":"CHF5074 reduces biomarkers of neuroinflammation in patients with mild cognitive impairment: a 12-week, double-blind, placebo-controlled study","title_match":false,"year":2013},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/lecanemab-appropriate-use-recommendations-37357276","doi":"10.14283/jpad.2023.30","journal":"The Journal of Prevention of Alzheimer s Disease","n_participants":null,"pmid":"37357276","source_url":"https://pubmed.ncbi.nlm.nih.gov/37357276/","study_design":null,"title":"Lecanemab: Appropriate Use Recommendations","title_match":false,"year":2023},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/fibrillar-amyloid-burden-in-cognitively-normal-people-at-3-levels-of-19346482","doi":"10.1073/pnas.0900345106","journal":"Proceedings of the National Academy of Sciences","n_participants":null,"pmid":"19346482","source_url":"https://pubmed.ncbi.nlm.nih.gov/19346482/","study_design":null,"title":"Fibrillar amyloid-\u03b2 burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease","title_match":false,"year":2009},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/human-apoe-isoforms-differentially-regulate-brain-amyloid-peptide-21715678","doi":"10.1126/scitranslmed.3002156","journal":"Science Translational Medicine","n_participants":null,"pmid":"21715678","source_url":"https://pubmed.ncbi.nlm.nih.gov/21715678/","study_design":null,"title":"Human apoE Isoforms Differentially Regulate Brain Amyloid-\u03b2 Peptide Clearance","title_match":false,"year":2011},{"alzhub_score":51,"alzhub_url":"https://alzhub.org/study/trem2-and-neurodegenerative-disease-1f8a1527","doi":"10.1056/nejmc1306509","journal":"New England Journal of Medicine","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1056/nejmc1306509","study_design":null,"title":"TREM2 and Neurodegenerative Disease","title_match":false,"year":2013},{"alzhub_score":44,"alzhub_url":"https://alzhub.org/study/consensus-report-of-the-working-group-on-molecular-and-biochemical-73d1d490","doi":"10.1016/s0197-4580(98)00022-0","journal":"Neurobiology of Aging","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1016/s0197-4580(98)00022-0","study_design":null,"title":"Consensus Report of the Working Group on: \u201cMolecular and Biochemical Markers of Alzheimer\u2019s Disease\u201d","title_match":false,"year":1998},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-isoform-dependent-amyloid-deposition-and-neuritic-10694577","doi":"10.1073/pnas.050004797","journal":"Proceedings of the National Academy of Sciences","n_participants":null,"pmid":"10694577","source_url":"https://pubmed.ncbi.nlm.nih.gov/10694577/","study_design":null,"title":"Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease","title_match":false,"year":2000},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/onset-of-alzheimer-disease-in-apolipoprotein-4-carriers-is-earlier-in-2fcd5460","doi":"10.1101/2024.01.02.24300718","journal":"BMC neurology","n_participants":33,"pmid":null,"source_url":"https://doi.org/10.1101/2024.01.02.24300718","study_design":null,"title":"Onset of Alzheimer disease in apolipoprotein \u025b4 carriers is earlier in butyrylcholinesterase K variant carriers","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/network-medicine-links-sars-cov-2-covid-19-infection-to-brain-34108016","doi":"10.1186/s13195-021-00850-3","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"34108016","source_url":"https://pubmed.ncbi.nlm.nih.gov/34108016/","study_design":null,"title":"Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment","title_match":false,"year":2021},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/opposing-effects-of-viral-mediated-brain-expression-of-apolipoprotein-25871773","doi":"10.1186/s13024-015-0001-3","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"25871773","source_url":"https://pubmed.ncbi.nlm.nih.gov/25871773/","study_design":null,"title":"Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and A\u03b2 metabolism in apoE4-targeted replacement mice","title_match":true,"year":2015},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/beta-amyloid-deposition-in-chronic-traumatic-encephalopathy-25943889","doi":"10.1007/s00401-015-1435-y","journal":"Acta neuropathologica","n_participants":114,"pmid":"25943889","source_url":"https://pubmed.ncbi.nlm.nih.gov/25943889/","study_design":null,"title":"Beta-amyloid deposition in chronic traumatic encephalopathy","title_match":false,"year":2015},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/blood-brain-barrier-breakdown-in-alzheimer-s-disease-mechanisms-and-38003477","doi":"10.3390/ijms242216288","journal":"International journal of molecular sciences","n_participants":null,"pmid":"38003477","source_url":"https://pubmed.ncbi.nlm.nih.gov/38003477/","study_design":null,"title":"Blood-Brain Barrier Breakdown in Alzheimer's Disease: Mechanisms and Targeted Strategies","title_match":false,"year":2023},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apoe4-exacerbates-synuclein-pathology-and-related-toxicity-32024798","doi":"10.1126/scitranslmed.aay1809","journal":"Science translational medicine","n_participants":null,"pmid":"32024798","source_url":"https://pubmed.ncbi.nlm.nih.gov/32024798/","study_design":null,"title":"APOE4 exacerbates \u03b1-synuclein pathology and related toxicity independent of amyloid","title_match":true,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-as-a-therapeutic-target-in-alzheimer-s-disease-a-27328687","doi":"10.1007/s40263-016-0361-4","journal":"CNS drugs","n_participants":null,"pmid":"27328687","source_url":"https://pubmed.ncbi.nlm.nih.gov/27328687/","study_design":null,"title":"Apolipoprotein E as a Therapeutic Target in Alzheimer's Disease: A Review of Basic Research and Clinical Evidence","title_match":false,"year":2016},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-biomarkers-of-neurodegeneration-synaptic-30853464","doi":"10.1016/j.jalz.2019.01.004","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":770,"pmid":"30853464","source_url":"https://pubmed.ncbi.nlm.nih.gov/30853464/","study_design":null,"title":"Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum","title_match":false,"year":2019},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-24234352","doi":"10.1055/s-0033-1359319","journal":"Seminars in neurology","n_participants":null,"pmid":"24234352","source_url":"https://pubmed.ncbi.nlm.nih.gov/24234352/","study_design":null,"title":"Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/genetic-restoration-of-plasma-apoe-improves-cognition-and-partially-27683909","doi":"10.1523/jneurosci.1054-16.2016","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"27683909","source_url":"https://pubmed.ncbi.nlm.nih.gov/27683909/","study_design":null,"title":"Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice","title_match":false,"year":2016},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/reelin-protects-against-amyloid-toxicity-in-vivo-26152694","doi":"10.1126/scisignal.aaa6674","journal":"Science signaling","n_participants":null,"pmid":"26152694","source_url":"https://pubmed.ncbi.nlm.nih.gov/26152694/","study_design":null,"title":"Reelin protects against amyloid \u03b2 toxicity in vivo","title_match":false,"year":2015},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-including-focal-presentations-30925614","doi":"10.1055/s-0039-1681041","journal":"Seminars in neurology","n_participants":null,"pmid":"30925614","source_url":"https://pubmed.ncbi.nlm.nih.gov/30925614/","study_design":null,"title":"Alzheimer's Disease Including Focal Presentations","title_match":false,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/stress-as-risk-factor-for-alzheimer-s-disease-29689315","doi":"10.1016/j.phrs.2018.04.017","journal":"Pharmacological research","n_participants":null,"pmid":"29689315","source_url":"https://pubmed.ncbi.nlm.nih.gov/29689315/","study_design":null,"title":"Stress as risk factor for Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/the-sigma-2-receptor-tmem97-pgrmc1-and-ldl-receptor-complex-are-32572762","doi":"10.1007/s12035-020-01988-1","journal":"Molecular neurobiology","n_participants":null,"pmid":"32572762","source_url":"https://pubmed.ncbi.nlm.nih.gov/32572762/","study_design":null,"title":"The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of A\u03b242 and Its Protein Aggregates","title_match":false,"year":2020},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/apoe2-gene-therapy-reduces-amyloid-deposition-and-improves-markers-of-38504517","doi":"10.1016/j.ymthe.2024.03.024","journal":"Molecular therapy : the journal of the American Society of Gene Therapy","n_participants":null,"pmid":"38504517","source_url":"https://pubmed.ncbi.nlm.nih.gov/38504517/","study_design":null,"title":"APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease","title_match":false,"year":2024},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/consequences-of-metabolic-disruption-in-alzheimer-s-disease-pathology-31270743","doi":"10.1007/s13311-019-00755-y","journal":"Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics","n_participants":null,"pmid":"31270743","source_url":"https://pubmed.ncbi.nlm.nih.gov/31270743/","study_design":null,"title":"Consequences of Metabolic Disruption in Alzheimer's Disease Pathology","title_match":false,"year":2019},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/systematic-review-factors-associated-with-risk-for-and-possible-20547887","doi":"10.7326/0003-4819-153-3-201008030-00258","journal":"Annals of internal medicine","n_participants":null,"pmid":"20547887","source_url":"https://pubmed.ncbi.nlm.nih.gov/20547887/","study_design":null,"title":"Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life","title_match":false,"year":2010},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/association-of-long-term-adherence-to-the-mind-diet-with-cognitive-29380849","doi":"10.1007/s12603-017-0909-0","journal":"The journal of nutrition, health & aging","n_participants":16058,"pmid":"29380849","source_url":"https://pubmed.ncbi.nlm.nih.gov/29380849/","study_design":"cohort study","title":"Association of Long-Term Adherence to the MIND Diet with Cognitive Function and Cognitive Decline in American Women","title_match":false,"year":2018},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/mediterranean-dash-intervention-for-neurodegenerative-delay-mind-diet-31686099","doi":"10.14283/jpad.2019.28","journal":"The journal of prevention of Alzheimer's disease","n_participants":106,"pmid":"31686099","source_url":"https://pubmed.ncbi.nlm.nih.gov/31686099/","study_design":"cohort study","title":"Mediterranean-Dash Intervention for Neurodegenerative Delay (MIND) Diet Slows Cognitive Decline After Stroke","title_match":false,"year":2019},{"alzhub_score":84,"alzhub_url":"https://alzhub.org/study/japan-multimodal-intervention-trial-for-the-prevention-of-dementia-a-38646854","doi":"10.1002/alz.13838","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":531,"pmid":"38646854","source_url":"https://pubmed.ncbi.nlm.nih.gov/38646854/","study_design":null,"title":"Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial","title_match":false,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/mediterranean-diet-adherence-and-rate-of-cerebral-a-amyloid-30375373","doi":"10.1038/s41398-018-0293-5","journal":"Translational psychiatry","n_participants":77,"pmid":"30375373","source_url":"https://pubmed.ncbi.nlm.nih.gov/30375373/","study_design":null,"title":"Mediterranean diet adherence and rate of cerebral A\u03b2-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing","title_match":false,"year":2018},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/genotype-patterns-at-clu-cr1-picalm-and-apoe-cognition-and-24643340","doi":"10.1007/s12263-014-0393-7","journal":"Genes & nutrition","n_participants":522,"pmid":"24643340","source_url":"https://pubmed.ncbi.nlm.nih.gov/24643340/","study_design":"randomized controlled trial","title":"Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMED-NAVARRA trial","title_match":false,"year":2014},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/a-multimodal-precision-prevention-approach-combining-lifestyle-38297399","doi":"10.1186/s13195-023-01355-x","journal":"Alzheimer's research & therapy","n_participants":600,"pmid":"38297399","source_url":"https://pubmed.ncbi.nlm.nih.gov/38297399/","study_design":null,"title":"A multimodal precision-prevention approach combining lifestyle intervention with metformin repurposing to prevent cognitive impairment and disability: the MET-FINGER randomised controlled trial protocol","title_match":false,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/lifespan-intellectual-factors-genetic-susceptibility-and-cognitive-31214016","doi":"10.3389/fnagi.2019.00129","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"31214016","source_url":"https://pubmed.ncbi.nlm.nih.gov/31214016/","study_design":"narrative review","title":"Lifespan Intellectual Factors, Genetic Susceptibility, and Cognitive Phenotypes in Aging: Implications for Interventions","title_match":false,"year":2019},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/dietary-patterns-are-related-to-cognitive-functioning-in-elderly-32472387","doi":"10.1007/s00394-020-02257-6","journal":"European journal of nutrition","n_participants":60,"pmid":"32472387","source_url":"https://pubmed.ncbi.nlm.nih.gov/32472387/","study_design":"cross-sectional","title":"Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/n-3-fatty-acids-mediterranean-diet-and-cognitive-function-in-normal-28213052","doi":"10.1016/j.exger.2017.02.008","journal":"Experimental gerontology","n_participants":null,"pmid":"28213052","source_url":"https://pubmed.ncbi.nlm.nih.gov/28213052/","study_design":"systematic review","title":"n-3 Fatty acids, Mediterranean diet and cognitive function in normal aging: A systematic review","title_match":false,"year":2017},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/vitamin-d-intake-is-associated-with-dementia-risk-in-the-washington-32921000","doi":"10.1002/alz.12096","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":329,"pmid":"32921000","source_url":"https://pubmed.ncbi.nlm.nih.gov/32921000/","study_design":"longitudinal study","title":"Vitamin D intake is associated with dementia risk in the Washington Heights-Inwood Columbia Aging Project (WHICAP)","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-and-insulin-resistance-interact-to-impair-cognition-28272510","doi":"10.1038/srep43701","journal":"Scientific reports","n_participants":null,"pmid":"28272510","source_url":"https://pubmed.ncbi.nlm.nih.gov/28272510/","study_design":null,"title":"Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome","title_match":true,"year":2017},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/evaluation-of-tdp-43-proteinopathy-and-hippocampal-sclerosis-in-30093249","doi":"10.1016/s1474-4422(18)30251-5","journal":"The Lancet. Neurology","n_participants":15,"pmid":"30093249","source_url":"https://pubmed.ncbi.nlm.nih.gov/30093249/","study_design":"cohort study","title":"Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE \u03b54 haplotype status: a community-based cohort study","title_match":true,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/effects-of-age-on-tissues-and-regions-of-the-cerebrum-and-cerebellum-11445259","doi":"10.1016/s0197-4580(01)00217-2","journal":"Neurobiology of aging","n_participants":null,"pmid":"11445259","source_url":"https://pubmed.ncbi.nlm.nih.gov/11445259/","study_design":null,"title":"Effects of age on tissues and regions of the cerebrum and cerebellum","title_match":false,"year":2001},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/memory-loss-in-alzheimer-s-disease-24459411","doi":"10.31887/dcns.2013.15.4/hjahn","journal":"Dialogues in clinical neuroscience","n_participants":null,"pmid":"24459411","source_url":"https://pubmed.ncbi.nlm.nih.gov/24459411/","study_design":null,"title":"Memory loss in Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/sex-differences-in-the-association-between-ad-biomarkers-and-26843008","doi":"10.1007/s11682-016-9523-8","journal":"Brain imaging and behavior","n_participants":348,"pmid":"26843008","source_url":"https://pubmed.ncbi.nlm.nih.gov/26843008/","study_design":"cross-sectional","title":"Sex differences in the association between AD biomarkers and cognitive decline","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neurocognitive-impairment-in-obstructive-sleep-apnea-22670023","doi":"10.1378/chest.11-2214","journal":"Chest","n_participants":null,"pmid":"22670023","source_url":"https://pubmed.ncbi.nlm.nih.gov/22670023/","study_design":null,"title":"Neurocognitive impairment in obstructive sleep apnea","title_match":false,"year":2012},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/aducanumab-gantenerumab-ban2401-and-alz-801-the-first-wave-of-amyloid-32787971","doi":"10.1186/s13195-020-00663-w","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"32787971","source_url":"https://pubmed.ncbi.nlm.nih.gov/32787971/","study_design":"clinical trial","title":"Aducanumab, gantenerumab, BAN2401, and ALZ-801-the first wave of amyloid-targeting drugs for Alzheimer's disease with potential for near term approval","title_match":false,"year":2020},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/independent-predictors-of-cognitive-decline-in-healthy-elderly-persons-11939895","doi":"10.1001/archneur.59.4.601","journal":"Archives of neurology","n_participants":48,"pmid":"11939895","source_url":"https://pubmed.ncbi.nlm.nih.gov/11939895/","study_design":"cohort study","title":"Independent predictors of cognitive decline in healthy elderly persons","title_match":false,"year":2002},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/diagnostic-and-prognostic-plasma-biomarkers-for-preclinical-alzheimer-34494715","doi":"10.1002/alz.12447","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"34494715","source_url":"https://pubmed.ncbi.nlm.nih.gov/34494715/","study_design":"longitudinal study","title":"Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/increased-alzheimer-s-risk-during-the-menopause-transition-a-3-year-30540774","doi":"10.1371/journal.pone.0207885","journal":"PloS one","n_participants":41,"pmid":"30540774","source_url":"https://pubmed.ncbi.nlm.nih.gov/30540774/","study_design":null,"title":"Increased Alzheimer's risk during the menopause transition: A 3-year longitudinal brain imaging study","title_match":false,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/reduced-hippocampal-volume-in-healthy-young-apoe4-carriers-an-mri-23152815","doi":"10.1371/journal.pone.0048895","journal":"PloS one","n_participants":null,"pmid":"23152815","source_url":"https://pubmed.ncbi.nlm.nih.gov/23152815/","study_design":null,"title":"Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study","title_match":true,"year":2012},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/longitudinal-change-of-biomarkers-in-cognitive-decline-21670386","doi":"10.1001/archneurol.2011.123","journal":"Archives of neurology","n_participants":819,"pmid":"21670386","source_url":"https://pubmed.ncbi.nlm.nih.gov/21670386/","study_design":"cohort study","title":"Longitudinal change of biomarkers in cognitive decline","title_match":false,"year":2011},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/memory-decline-accompanies-subthreshold-amyloid-accumulation-29572282","doi":"10.1212/wnl.0000000000005354","journal":"Neurology","n_participants":13,"pmid":"29572282","source_url":"https://pubmed.ncbi.nlm.nih.gov/29572282/","study_design":"longitudinal study","title":"Memory decline accompanies subthreshold amyloid accumulation","title_match":false,"year":2018},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/longitudinal-change-in-hippocampal-volume-as-a-function-of-10891924","doi":"10.1212/wnl.55.1.134","journal":"Neurology","n_participants":null,"pmid":"10891924","source_url":"https://pubmed.ncbi.nlm.nih.gov/10891924/","study_design":"longitudinal study","title":"Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype","title_match":false,"year":2000},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/effect-of-apolipoprotein-e-genotype-on-hippocampal-volume-loss-in-11756601","doi":"10.1212/wnl.57.12.2223","journal":"Neurology","n_participants":null,"pmid":"11756601","source_url":"https://pubmed.ncbi.nlm.nih.gov/11756601/","study_design":null,"title":"Effect of apolipoprotein E genotype on hippocampal volume loss in aging healthy women","title_match":false,"year":2001},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/longitudinal-neuroimaging-correlates-of-subjective-memory-impairment-21357878","doi":"10.1192/bjp.bp.110.078683","journal":"The British journal of psychiatry : the journal of mental science","n_participants":1336,"pmid":"21357878","source_url":"https://pubmed.ncbi.nlm.nih.gov/21357878/","study_design":"cohort study","title":"Longitudinal neuroimaging correlates of subjective memory impairment: 4-year prospective community study","title_match":false,"year":2011},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/association-of-metabolic-dysregulation-with-volumetric-brain-magnetic-21680719","doi":"10.2337/dc11-0308","journal":"Diabetes care","n_participants":2439,"pmid":"21680719","source_url":"https://pubmed.ncbi.nlm.nih.gov/21680719/","study_design":"cross-sectional","title":"Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the Framingham Offspring Study","title_match":false,"year":2011},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/cognitive-and-brain-profiles-associated-with-current-neuroimaging-26203136","doi":"10.1523/jneurosci.0150-15.2015","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"26203136","source_url":"https://pubmed.ncbi.nlm.nih.gov/26203136/","study_design":null,"title":"Cognitive and Brain Profiles Associated with Current Neuroimaging Biomarkers of Preclinical Alzheimer's Disease","title_match":false,"year":2015},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/3d-pib-and-csf-biomarker-associations-with-hippocampal-atrophy-in-20538372","doi":"10.1016/j.neurobiolaging.2010.05.003","journal":"Neurobiology of aging","n_participants":98,"pmid":"20538372","source_url":"https://pubmed.ncbi.nlm.nih.gov/20538372/","study_design":null,"title":"3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects","title_match":false,"year":2010},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/physical-activity-reduces-hippocampal-atrophy-in-elders-at-genetic-24795624","doi":"10.3389/fnagi.2014.00061","journal":"Frontiers in aging neuroscience","n_participants":24,"pmid":"24795624","source_url":"https://pubmed.ncbi.nlm.nih.gov/24795624/","study_design":"longitudinal study","title":"Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":78,"alzhub_url":"https://alzhub.org/study/brain-delivery-of-supplemental-docosahexaenoic-acid-dha-a-randomized-32690472","doi":"10.1016/j.ebiom.2020.102883","journal":"EBioMedicine","n_participants":33,"pmid":"32690472","source_url":"https://pubmed.ncbi.nlm.nih.gov/32690472/","study_design":null,"title":"Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial","title_match":false,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-epsilon-4-allele-and-hippocampal-volume-in-twins-9109888","doi":"10.1212/wnl.48.4.985","journal":"Neurology","n_participants":null,"pmid":"9109888","source_url":"https://pubmed.ncbi.nlm.nih.gov/9109888/","study_design":null,"title":"Apolipoprotein E epsilon 4 allele and hippocampal volume in twins with normal cognition","title_match":false,"year":1997},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-epsilon-4-and-the-pattern-of-regional-brain-atrophy-11673590","doi":"10.1212/wnl.57.8.1461","journal":"Neurology","n_participants":46,"pmid":"11673590","source_url":"https://pubmed.ncbi.nlm.nih.gov/11673590/","study_design":null,"title":"Apolipoprotein E epsilon 4 and the pattern of regional brain atrophy in Alzheimer's disease","title_match":false,"year":2001},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/rate-of-memory-decline-in-ad-is-related-to-education-and-occupation-10599762","doi":"10.1212/wnl.53.9.1942","journal":"Neurology","n_participants":177,"pmid":"10599762","source_url":"https://pubmed.ncbi.nlm.nih.gov/10599762/","study_design":null,"title":"Rate of memory decline in AD is related to education and occupation: cognitive reserve?","title_match":false,"year":1999},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/motor-dysfunction-in-mild-cognitive-impairment-and-the-risk-of-17172617","doi":"10.1001/archneur.63.12.1763","journal":"Archives of neurology","n_participants":558,"pmid":"17172617","source_url":"https://pubmed.ncbi.nlm.nih.gov/17172617/","study_design":"cohort study","title":"Motor dysfunction in mild cognitive impairment and the risk of incident Alzheimer disease","title_match":false,"year":2006},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/associations-between-serum-cholesterol-levels-and-cerebral-amyloidosis-24378418","doi":"10.1001/jamaneurol.2013.5390","journal":"JAMA neurology","n_participants":33,"pmid":"24378418","source_url":"https://pubmed.ncbi.nlm.nih.gov/24378418/","study_design":"cross-sectional","title":"Associations between serum cholesterol levels and cerebral amyloidosis","title_match":false,"year":2014},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/epidemiological-studies-of-the-effect-of-stroke-on-incident-dementia-19910553","doi":"10.1161/strokeaha.109.559880","journal":"Stroke","n_participants":null,"pmid":"19910553","source_url":"https://pubmed.ncbi.nlm.nih.gov/19910553/","study_design":"systematic review","title":"Epidemiological studies of the effect of stroke on incident dementia: a systematic review","title_match":false,"year":2010},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/alcohol-intake-and-risk-of-dementia-15066068","doi":"10.1111/j.1532-5415.2004.52159.x","journal":"Journal of the American Geriatrics Society","n_participants":260,"pmid":"15066068","source_url":"https://pubmed.ncbi.nlm.nih.gov/15066068/","study_design":"cohort study","title":"Alcohol intake and risk of dementia","title_match":false,"year":2004},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/diabetes-mellitus-and-risk-of-developing-alzheimer-disease-results-17101823","doi":"10.1001/archneur.63.11.1551","journal":"Archives of neurology","n_participants":2210,"pmid":"17101823","source_url":"https://pubmed.ncbi.nlm.nih.gov/17101823/","study_design":"cohort study","title":"Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study","title_match":false,"year":2006},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/association-of-metabolic-syndrome-with-alzheimer-disease-a-population-16966548","doi":"10.1212/01.wnl.0000234037.91185.99","journal":"Neurology","n_participants":959,"pmid":"16966548","source_url":"https://pubmed.ncbi.nlm.nih.gov/16966548/","study_design":null,"title":"Association of metabolic syndrome with Alzheimer disease: a population-based study","title_match":false,"year":2006},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/use-of-statins-and-incidence-of-dementia-and-cognitive-impairment-18663180","doi":"10.1212/01.wnl.0000319647.15752.7b","journal":"Neurology","n_participants":1674,"pmid":"18663180","source_url":"https://pubmed.ncbi.nlm.nih.gov/18663180/","study_design":"cohort study","title":"Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study","title_match":false,"year":2008},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/cerebrovascular-and-brain-morphologic-correlates-of-mild-cognitive-11295996","doi":"10.1001/archneur.58.4.643","journal":"Archives of neurology","n_participants":null,"pmid":"11295996","source_url":"https://pubmed.ncbi.nlm.nih.gov/11295996/","study_design":"longitudinal study","title":"Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart, Lung, and Blood Institute Twin Study","title_match":false,"year":2001},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/higher-aortic-stiffness-is-related-to-lower-cerebral-blood-flow-and-30018169","doi":"10.1161/circulationaha.118.032410","journal":"Circulation","n_participants":155,"pmid":"30018169","source_url":"https://pubmed.ncbi.nlm.nih.gov/30018169/","study_design":null,"title":"Higher Aortic Stiffness Is Related to Lower Cerebral Blood Flow and Preserved Cerebrovascular Reactivity in Older Adults","title_match":false,"year":2018},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/metformin-use-is-associated-with-slowed-cognitive-decline-and-reduced-32967921","doi":"10.2337/dc20-0892","journal":"Diabetes care","n_participants":1037,"pmid":"32967921","source_url":"https://pubmed.ncbi.nlm.nih.gov/32967921/","study_design":null,"title":"Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes: The Sydney Memory and Ageing Study","title_match":false,"year":2020},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/measures-of-adiposity-and-dementia-risk-in-elderly-persons-17353383","doi":"10.1001/archneur.64.3.392","journal":"Archives of neurology","n_participants":893,"pmid":"17353383","source_url":"https://pubmed.ncbi.nlm.nih.gov/17353383/","study_design":null,"title":"Measures of adiposity and dementia risk in elderly persons","title_match":false,"year":2007},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/endogenous-estrogen-levels-and-alzheimer-s-disease-among-10690972","doi":"10.1212/wnl.54.4.833","journal":"Neurology","n_participants":50,"pmid":"10690972","source_url":"https://pubmed.ncbi.nlm.nih.gov/10690972/","study_design":"case-control study","title":"Endogenous estrogen levels and Alzheimer's disease among postmenopausal women","title_match":false,"year":2000},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/thyroid-function-and-the-risk-of-alzheimer-disease-the-framingham-18663163","doi":"10.1001/archinte.168.14.1514","journal":"Archives of internal medicine","n_participants":209,"pmid":"18663163","source_url":"https://pubmed.ncbi.nlm.nih.gov/18663163/","study_design":null,"title":"Thyroid function and the risk of Alzheimer disease: the Framingham Study","title_match":false,"year":2008},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/dementia-stroke-and-vascular-risk-factors-a-review-22188853","doi":"10.1111/j.1747-4949.2011.00731.x","journal":"International journal of stroke : official journal of the International Stroke Society","n_participants":null,"pmid":"22188853","source_url":"https://pubmed.ncbi.nlm.nih.gov/22188853/","study_design":null,"title":"Dementia, stroke, and vascular risk factors; a review","title_match":false,"year":2012},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/tau-extent-is-associated-with-lower-cognition-in-down-syndrome-42928420","doi":"10.1002/alz.71925","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"42928420","source_url":"https://pubmed.ncbi.nlm.nih.gov/42928420/","study_design":null,"title":"Tau extent is associated with lower cognition in Down syndrome-related Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/dementia-in-africa-current-evidence-knowledge-gaps-and-future-34569714","doi":"10.1002/alz.12432","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"34569714","source_url":"https://pubmed.ncbi.nlm.nih.gov/34569714/","study_design":"longitudinal study","title":"Dementia in Africa: Current evidence, knowledge gaps, and future directions","title_match":false,"year":2022},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-and-genetics-in-the-diagnosis-and-prediction-of-35383826","doi":"10.1093/brain/awac128","journal":"Brain : a journal of neurology","n_participants":1439,"pmid":"35383826","source_url":"https://pubmed.ncbi.nlm.nih.gov/35383826/","study_design":"case-control study","title":"Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/an-accurate-fully-automated-panel-of-plasma-biomarkers-for-alzheimer-35950735","doi":"10.1002/alz.12751","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":920,"pmid":"35950735","source_url":"https://pubmed.ncbi.nlm.nih.gov/35950735/","study_design":null,"title":"An accurate fully automated panel of plasma biomarkers for Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/markers-of-neuroinflammation-associated-with-alzheimer-s-disease-28161476","doi":"10.1016/j.bbi.2017.01.020","journal":"Brain, behavior, and immunity","n_participants":48,"pmid":"28161476","source_url":"https://pubmed.ncbi.nlm.nih.gov/28161476/","study_design":"cross-sectional","title":"Markers of neuroinflammation associated with Alzheimer's disease pathology in older adults","title_match":false,"year":2017},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/cerebral-and-extracerebral-cholesterol-metabolism-and-csf-markers-of-23291240","doi":"10.1016/j.bcp.2012.12.007","journal":"Biochemical pharmacology","n_participants":86,"pmid":"23291240","source_url":"https://pubmed.ncbi.nlm.nih.gov/23291240/","study_design":null,"title":"Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/multi-analyte-proteomic-analysis-identifies-blood-based-39385222","doi":"10.1186/s13024-024-00753-5","journal":"Molecular neurodegeneration","n_participants":113,"pmid":"39385222","source_url":"https://pubmed.ncbi.nlm.nih.gov/39385222/","study_design":"cross-sectional","title":"Multi-analyte proteomic analysis identifies blood-based neuroinflammation, cerebrovascular and synaptic biomarkers in preclinical Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/application-of-the-atn-classification-scheme-in-a-population-without-33811742","doi":"10.1002/alz.12292","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"33811742","source_url":"https://pubmed.ncbi.nlm.nih.gov/33811742/","study_design":null,"title":"Application of the ATN classification scheme in a population without dementia: Findings from the EPAD cohort","title_match":false,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-lipid-homeostasis-in-the-etiology-and-treatment-24973118","doi":"10.1016/j.neurobiolaging.2014.03.037","journal":"Neurobiology of aging","n_participants":null,"pmid":"24973118","source_url":"https://pubmed.ncbi.nlm.nih.gov/24973118/","study_design":null,"title":"Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-and-p-tau217-a1-42-are-effective-biomarkers-for-39887504","doi":"10.1002/alz.14536","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39887504","source_url":"https://pubmed.ncbi.nlm.nih.gov/39887504/","study_design":null,"title":"Plasma p-tau217 and p-tau217/A\u03b21-42 are effective biomarkers for identifying CSF- and PET imaging-diagnosed Alzheimer's disease: Insights for research and clinical practice","title_match":false,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-181-predicts-amyloid-status-and-conversion-37012068","doi":"10.1136/jnnp-2022-330540","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"37012068","source_url":"https://pubmed.ncbi.nlm.nih.gov/37012068/","study_design":null,"title":"Plasma phosphorylated tau 181 predicts amyloid status and conversion to dementia stage dependent on renal function","title_match":false,"year":2023},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/the-bio-hermes-study-biomarker-database-developed-to-investigate-38415908","doi":"10.1002/alz.13722","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":417,"pmid":"38415908","source_url":"https://pubmed.ncbi.nlm.nih.gov/38415908/","study_design":null,"title":"The Bio-Hermes Study: Biomarker database developed to investigate blood-based and digital biomarkers in community-based, diverse populations clinically screened for Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/plasma-glial-fibrillary-acidic-protein-is-elevated-in-cognitively-33431793","doi":"10.1038/s41398-020-01137-1","journal":"Translational psychiatry","n_participants":63,"pmid":"33431793","source_url":"https://pubmed.ncbi.nlm.nih.gov/33431793/","study_design":"cross-sectional","title":"Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/the-gut-microbiota-derived-metabolite-trimethylamine-n-oxide-is-30579367","doi":"10.1186/s13195-018-0451-2","journal":"Alzheimer's research & therapy","n_participants":410,"pmid":"30579367","source_url":"https://pubmed.ncbi.nlm.nih.gov/30579367/","study_design":null,"title":"The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease","title_match":false,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neuron-specific-apolipoprotein-e4-proteolysis-is-associated-with-15014128","doi":"10.1523/jneurosci.4315-03.2004","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"15014128","source_url":"https://pubmed.ncbi.nlm.nih.gov/15014128/","study_design":null,"title":"Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice","title_match":true,"year":2004},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/glial-fibrillary-acidic-protein-apolipoprotein-e-apoe-transgenic-mice-9547235","doi":"10.1523/jneurosci.18-09-03261.1998","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"9547235","source_url":"https://pubmed.ncbi.nlm.nih.gov/9547235/","study_design":null,"title":"Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins","title_match":true,"year":1998},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/a-blood-based-diagnostic-test-incorporating-plasma-a42-40-ratio-apoe-33933117","doi":"10.1186/s13024-021-00451-6","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"33933117","source_url":"https://pubmed.ncbi.nlm.nih.gov/33933117/","study_design":null,"title":"A blood-based diagnostic test incorporating plasma A\u03b242/40 ratio, ApoE proteotype, and age accurately identifies brain amyloid status: findings from a multi cohort validity analysis","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-precivityadtm-test-accurate-and-reliable-lc-ms-ms-assays-for-34015303","doi":"10.1016/j.cca.2021.05.011","journal":"Clinica chimica acta; international journal of clinical chemistry","n_participants":null,"pmid":"34015303","source_url":"https://pubmed.ncbi.nlm.nih.gov/34015303/","study_design":null,"title":"The PrecivityAD\u2122 test: Accurate and reliable LC-MS/MS assays for quantifying plasma amyloid beta 40 and 42 and apolipoprotein E proteotype for the assessment of brain amyloidosis","title_match":false,"year":2021},{"alzhub_score":81,"alzhub_url":"https://alzhub.org/study/assessment-of-plasma-amyloid-42-40-and-cognitive-decline-among-33331917","doi":"10.1001/jamanetworkopen.2020.28634","journal":"JAMA network open","n_participants":448,"pmid":"33331917","source_url":"https://pubmed.ncbi.nlm.nih.gov/33331917/","study_design":"cohort study","title":"Assessment of Plasma Amyloid-\u03b242/40 and Cognitive Decline Among Community-Dwelling Older Adults","title_match":false,"year":2020},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/associations-between-air-pollution-and-biomarkers-of-alzheimer-s-34537521","doi":"10.1016/j.envint.2021.106864","journal":"Environment international","n_participants":156,"pmid":"34537521","source_url":"https://pubmed.ncbi.nlm.nih.gov/34537521/","study_design":null,"title":"Associations between air pollution and biomarkers of Alzheimer's disease in cognitively unimpaired individuals","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/linkage-whole-genome-sequence-and-biological-data-implicate-variants-29183403","doi":"10.1186/s13073-017-0486-1","journal":"Genome medicine","n_participants":null,"pmid":"29183403","source_url":"https://pubmed.ncbi.nlm.nih.gov/29183403/","study_design":null,"title":"Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience","title_match":false,"year":2017},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/the-psen1-p-e318g-variant-increases-the-risk-of-alzheimer-s-disease-23990795","doi":"10.1371/journal.pgen.1003685","journal":"PLoS genetics","n_participants":5161,"pmid":"23990795","source_url":"https://pubmed.ncbi.nlm.nih.gov/23990795/","study_design":"case-control study","title":"The PSEN1, p.E318G variant increases the risk of Alzheimer's disease in APOE-\u03b54 carriers","title_match":true,"year":2013},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/a-blood-based-screening-tool-for-alzheimer-s-disease-that-spans-serum-22163278","doi":"10.1371/journal.pone.0028092","journal":"PloS one","n_participants":null,"pmid":"22163278","source_url":"https://pubmed.ncbi.nlm.nih.gov/22163278/","study_design":null,"title":"A blood-based screening tool for Alzheimer's disease that spans serum and plasma: findings from TARC and ADNI","title_match":false,"year":2011},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/longitudinal-blood-biomarker-trajectories-in-preclinical-alzheimer-s-37294682","doi":"10.1002/alz.13318","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":373,"pmid":"37294682","source_url":"https://pubmed.ncbi.nlm.nih.gov/37294682/","study_design":"longitudinal study","title":"Longitudinal blood biomarker trajectories in preclinical Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/amyloid-misfolding-as-a-plasma-biomarker-indicates-risk-for-future-33357241","doi":"10.1186/s13195-020-00738-8","journal":"Alzheimer's research & therapy","n_participants":203,"pmid":"33357241","source_url":"https://pubmed.ncbi.nlm.nih.gov/33357241/","study_design":null,"title":"Amyloid-\u03b2 misfolding as a plasma biomarker indicates risk for future clinical Alzheimer's disease in individuals with subjective cognitive decline","title_match":false,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-involvement-of-lipids-in-alzheimer-s-disease-24894353","doi":"10.1016/j.jgg.2014.04.003","journal":"Journal of genetics and genomics = Yi chuan xue bao","n_participants":null,"pmid":"24894353","source_url":"https://pubmed.ncbi.nlm.nih.gov/24894353/","study_design":null,"title":"The involvement of lipids in Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/neurofilament-light-as-a-blood-biomarker-for-neurodegeneration-in-29631614","doi":"10.1186/s13195-018-0367-x","journal":"Alzheimer's research & therapy","n_participants":100,"pmid":"29631614","source_url":"https://pubmed.ncbi.nlm.nih.gov/29631614/","study_design":"cross-sectional","title":"Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome","title_match":false,"year":2018},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/transthyretin-decrease-in-plasma-of-mci-and-ad-patients-investigation-22698061","doi":"10.2174/156720512803251057","journal":"Current Alzheimer research","n_participants":55,"pmid":"22698061","source_url":"https://pubmed.ncbi.nlm.nih.gov/22698061/","study_design":null,"title":"Transthyretin decrease in plasma of MCI and AD patients: investigation of mechanisms for disease modulation","title_match":false,"year":2012},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/alzheimer-s-polygenic-risk-scores-apoe-alzheimer-s-disease-risk-and-37516890","doi":"10.1186/s13195-023-01277-8","journal":"Alzheimer's research & therapy","n_participants":712,"pmid":"37516890","source_url":"https://pubmed.ncbi.nlm.nih.gov/37516890/","study_design":"cohort study","title":"Alzheimer's polygenic risk scores, APOE, Alzheimer's disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-identify-older-adults-at-risk-of-alzheimer-s-36876954","doi":"10.1002/alz.12986","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":847,"pmid":"36876954","source_url":"https://pubmed.ncbi.nlm.nih.gov/36876954/","study_design":null,"title":"Plasma biomarkers identify older adults at risk of Alzheimer's disease and related dementias in a real-world population-based cohort","title_match":false,"year":2023},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/plasma-gfap-nfl-and-ptau-181-detect-preclinical-stages-of-dementia-38654932","doi":"10.3389/fendo.2024.1375302","journal":"Frontiers in endocrinology","n_participants":152,"pmid":"38654932","source_url":"https://pubmed.ncbi.nlm.nih.gov/38654932/","study_design":null,"title":"Plasma GFAP, NfL and pTau 181 detect preclinical stages of dementia","title_match":false,"year":2024},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/impact-of-pre-analytical-sample-handling-factors-on-plasma-biomarkers-36625424","doi":"10.1111/jnc.15757","journal":"Journal of neurochemistry","n_participants":null,"pmid":"36625424","source_url":"https://pubmed.ncbi.nlm.nih.gov/36625424/","study_design":null,"title":"Impact of pre-analytical sample handling factors on plasma biomarkers of Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/apoe4-leads-to-blood-brain-barrier-dysfunction-predicting-cognitive-32376954","doi":"10.1038/s41586-020-2247-3","journal":"Nature","n_participants":null,"pmid":"32376954","source_url":"https://pubmed.ncbi.nlm.nih.gov/32376954/","study_design":null,"title":"APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline","title_match":true,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apoe-influences-amyloid-a-clearance-despite-minimal-apoe-a-23620513","doi":"10.1073/pnas.1220484110","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"23620513","source_url":"https://pubmed.ncbi.nlm.nih.gov/23620513/","study_design":null,"title":"ApoE influences amyloid-\u03b2 (A\u03b2) clearance despite minimal apoE/A\u03b2 association in physiological conditions","title_match":false,"year":2013},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/associations-between-performance-on-an-abbreviated-cogstate-battery-27589532","doi":"10.3233/jad-160528","journal":"Journal of Alzheimer's disease : JAD","n_participants":71,"pmid":"27589532","source_url":"https://pubmed.ncbi.nlm.nih.gov/27589532/","study_design":null,"title":"Associations between Performance on an Abbreviated CogState Battery, Other Measures of Cognitive Function, and Biomarkers in People at Risk for Alzheimer's Disease","title_match":false,"year":2016},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/the-midlife-cognitive-profiles-of-adults-at-high-risk-of-late-onset-28365321","doi":"10.1016/j.jalz.2017.02.008","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":210,"pmid":"28365321","source_url":"https://pubmed.ncbi.nlm.nih.gov/28365321/","study_design":null,"title":"The midlife cognitive profiles of adults at high risk of late-onset Alzheimer's disease: The PREVENT study","title_match":false,"year":2017},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/sharper-in-the-morning-cognitive-time-of-day-effects-revealed-with-35037593","doi":"10.1080/13803395.2021.2009447","journal":"Journal of clinical and experimental neuropsychology","n_participants":169,"pmid":"35037593","source_url":"https://pubmed.ncbi.nlm.nih.gov/35037593/","study_design":null,"title":"Sharper in the morning: Cognitive time of day effects revealed with high-frequency smartphone testing","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/relationships-between-hourly-cognitive-variability-and-risk-of-37079810","doi":"10.1037/neu0000905","journal":"Neuropsychology","n_participants":null,"pmid":"37079810","source_url":"https://pubmed.ncbi.nlm.nih.gov/37079810/","study_design":null,"title":"Relationships between hourly cognitive variability and risk of Alzheimer's disease revealed with mixed-effects location scale models","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/naturalistic-assessment-of-reaction-time-variability-in-older-adults-38282413","doi":"10.1017/s1355617723011475","journal":"Journal of the International Neuropsychological Society : JINS","n_participants":null,"pmid":"38282413","source_url":"https://pubmed.ncbi.nlm.nih.gov/38282413/","study_design":null,"title":"Naturalistic assessment of reaction time variability in older adults at risk for Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/demonstrated-brain-insulin-resistance-in-alzheimer-s-disease-patients-22476197","doi":"10.1172/jci59903","journal":"The Journal of clinical investigation","n_participants":null,"pmid":"22476197","source_url":"https://pubmed.ncbi.nlm.nih.gov/22476197/","study_design":null,"title":"Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-far-more-than-a-lipid-transport-protein-11701639","doi":"10.1146/annurev.genom.1.1.507","journal":"Annual review of genomics and human genetics","n_participants":null,"pmid":"11701639","source_url":"https://pubmed.ncbi.nlm.nih.gov/11701639/","study_design":null,"title":"Apolipoprotein E: far more than a lipid transport protein","title_match":false,"year":2000},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/apoe-and-alzheimer-s-disease-advances-in-genetics-pathophysiology-and-33340485","doi":"10.1016/s1474-4422(20)30412-9","journal":"The Lancet. Neurology","n_participants":null,"pmid":"33340485","source_url":"https://pubmed.ncbi.nlm.nih.gov/33340485/","study_design":"meta-analysis","title":"APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches","title_match":false,"year":2021},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apoe4-causes-widespread-molecular-and-cellular-alterations-associated-29861287","doi":"10.1016/j.neuron.2018.05.008","journal":"Neuron","n_participants":null,"pmid":"29861287","source_url":"https://pubmed.ncbi.nlm.nih.gov/29861287/","study_design":null,"title":"APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types","title_match":true,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-a-causative-factor-and-therapeutic-target-in-16567625","doi":"10.1073/pnas.0600549103","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"16567625","source_url":"https://pubmed.ncbi.nlm.nih.gov/16567625/","study_design":null,"title":"Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease","title_match":true,"year":2006},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-structure-and-function-in-lipid-metabolism-25173806","doi":"10.1016/j.nbd.2014.08.025","journal":"Neurobiology of disease","n_participants":null,"pmid":"25173806","source_url":"https://pubmed.ncbi.nlm.nih.gov/25173806/","study_design":null,"title":"Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases","title_match":false,"year":2014},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-allele-specific-antioxidant-activity-and-effects-on-8782820","doi":"10.1038/ng0996-55","journal":"Nature genetics","n_participants":null,"pmid":"8782820","source_url":"https://pubmed.ncbi.nlm.nih.gov/8782820/","study_design":null,"title":"Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides","title_match":false,"year":1996},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/large-scale-deep-multi-layer-analysis-of-alzheimer-s-disease-brain-35115731","doi":"10.1038/s41593-021-00999-y","journal":"Nature neuroscience","n_participants":null,"pmid":"35115731","source_url":"https://pubmed.ncbi.nlm.nih.gov/35115731/","study_design":null,"title":"Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level","title_match":false,"year":2022},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apoe4-4-is-linked-to-damaging-lipid-droplets-in-alzheimer-s-disease-38480892","doi":"10.1038/s41586-024-07185-7","journal":"Nature","n_participants":null,"pmid":"38480892","source_url":"https://pubmed.ncbi.nlm.nih.gov/38480892/","study_design":null,"title":"APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia","title_match":true,"year":2024},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/accelerated-pericyte-degeneration-and-blood-brain-barrier-breakdown-25757756","doi":"10.1038/jcbfm.2015.44","journal":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","n_participants":null,"pmid":"25757756","source_url":"https://pubmed.ncbi.nlm.nih.gov/25757756/","study_design":null,"title":"Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease","title_match":true,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/differential-effects-of-apolipoproteins-e3-and-e4-on-neuronal-growth-8171342","doi":"10.1126/science.8171342","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"8171342","source_url":"https://pubmed.ncbi.nlm.nih.gov/8171342/","study_design":null,"title":"Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro","title_match":false,"year":1994},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/cerebral-metabolic-and-cognitive-decline-in-persons-at-genetic-risk-10811879","doi":"10.1073/pnas.090106797","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"10811879","source_url":"https://pubmed.ncbi.nlm.nih.gov/10811879/","study_design":"longitudinal study","title":"Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease","title_match":false,"year":2000},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amyloid-beta-peptide-1-42-induced-oxidative-stress-and-neurotoxicity-12607822","doi":"10.1080/1071576021000049890","journal":"Free radical research","n_participants":null,"pmid":"12607822","source_url":"https://pubmed.ncbi.nlm.nih.gov/12607822/","study_design":null,"title":"Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review","title_match":false,"year":2002},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/the-glia-neuron-lactate-shuttle-and-elevated-ros-promote-lipid-28965825","doi":"10.1016/j.cmet.2017.08.024","journal":"Cell metabolism","n_participants":null,"pmid":"28965825","source_url":"https://pubmed.ncbi.nlm.nih.gov/28965825/","study_design":null,"title":"The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apoe-and-a-in-alzheimer-s-disease-accidental-encounters-or-partners-24559670","doi":"10.1016/j.neuron.2014.01.045","journal":"Neuron","n_participants":null,"pmid":"24559670","source_url":"https://pubmed.ncbi.nlm.nih.gov/24559670/","study_design":null,"title":"ApoE and A\u03b2 in Alzheimer's disease: accidental encounters or partners?","title_match":false,"year":2014},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/meta-analysis-of-alzheimer-s-disease-risk-with-obesity-diabetes-and-19358976","doi":"10.1016/j.biopsych.2009.02.013","journal":"Biological psychiatry","n_participants":null,"pmid":"19358976","source_url":"https://pubmed.ncbi.nlm.nih.gov/19358976/","study_design":"meta-analysis","title":"Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders","title_match":false,"year":2010},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/a-quarter-century-of-apoe-and-alzheimer-s-disease-progress-to-date-30844401","doi":"10.1016/j.neuron.2019.01.056","journal":"Neuron","n_participants":null,"pmid":"30844401","source_url":"https://pubmed.ncbi.nlm.nih.gov/30844401/","study_design":null,"title":"A Quarter Century of APOE and Alzheimer's Disease: Progress to Date and the Path Forward","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/effects-of-intranasal-insulin-on-cognition-in-memory-impaired-older-15964100","doi":"10.1016/j.neurobiolaging.2005.03.016","journal":"Neurobiology of aging","n_participants":null,"pmid":"15964100","source_url":"https://pubmed.ncbi.nlm.nih.gov/15964100/","study_design":null,"title":"Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype","title_match":false,"year":2006},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/serum-total-cholesterol-apolipoprotein-e-epsilon-4-allele-and-9549720","doi":"10.1159/000026149","journal":"Neuroepidemiology","n_participants":null,"pmid":"9549720","source_url":"https://pubmed.ncbi.nlm.nih.gov/9549720/","study_design":null,"title":"Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease","title_match":false,"year":1998},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/herpes-simplex-virus-type-1-in-brain-and-risk-of-alzheimer-s-disease-9014911","doi":"10.1016/s0140-6736(96)10149-5","journal":"Lancet (London, England)","n_participants":40,"pmid":"9014911","source_url":"https://pubmed.ncbi.nlm.nih.gov/9014911/","study_design":null,"title":"Herpes simplex virus type 1 in brain and risk of Alzheimer's disease","title_match":false,"year":1997},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/efficacy-of-rosiglitazone-in-a-genetically-defined-population-with-16446752","doi":"10.1038/sj.tpj.6500369","journal":"The pharmacogenomics journal","n_participants":511,"pmid":"16446752","source_url":"https://pubmed.ncbi.nlm.nih.gov/16446752/","study_design":null,"title":"Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease","title_match":false,"year":2006},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/apoe4-impairs-myelination-via-cholesterol-dysregulation-in-36385529","doi":"10.1038/s41586-022-05439-w","journal":"Nature","n_participants":null,"pmid":"36385529","source_url":"https://pubmed.ncbi.nlm.nih.gov/36385529/","study_design":null,"title":"APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes","title_match":true,"year":2022},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/molecular-genetics-of-early-onset-alzheimer-s-disease-revisited-27016693","doi":"10.1016/j.jalz.2016.01.012","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"27016693","source_url":"https://pubmed.ncbi.nlm.nih.gov/27016693/","study_design":null,"title":"Molecular genetics of early-onset Alzheimer's disease revisited","title_match":false,"year":2016},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apoe2-apoe3-and-apoe4-differentially-stimulate-app-transcription-and-28111074","doi":"10.1016/j.cell.2016.12.044","journal":"Cell","n_participants":null,"pmid":"28111074","source_url":"https://pubmed.ncbi.nlm.nih.gov/28111074/","study_design":null,"title":"ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and A\u03b2 Secretion","title_match":true,"year":2017},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/prediction-of-cognitive-decline-in-normal-elderly-subjects-with-2-18-11526211","doi":"10.1073/pnas.191044198","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":12,"pmid":"11526211","source_url":"https://pubmed.ncbi.nlm.nih.gov/11526211/","study_design":"longitudinal study","title":"Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-D-glucose/poitron-emission tomography (FDG/PET)","title_match":false,"year":2001},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-structure-determines-function-from-atherosclerosis-19106071","doi":"10.1194/jlr.r800069-jlr200","journal":"Journal of lipid research","n_participants":null,"pmid":"19106071","source_url":"https://pubmed.ncbi.nlm.nih.gov/19106071/","study_design":null,"title":"Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS","title_match":false,"year":2009},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/genome-wide-association-analysis-reveals-putative-alzheimer-s-disease-18976728","doi":"10.1016/j.ajhg.2008.10.008","journal":"American journal of human genetics","n_participants":2700,"pmid":"18976728","source_url":"https://pubmed.ncbi.nlm.nih.gov/18976728/","study_design":null,"title":"Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE","title_match":false,"year":2008},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/integrating-human-brain-proteomes-with-genome-wide-association-data-33510477","doi":"10.1038/s41588-020-00773-z","journal":"Nature genetics","n_participants":null,"pmid":"33510477","source_url":"https://pubmed.ncbi.nlm.nih.gov/33510477/","study_design":null,"title":"Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis","title_match":false,"year":2021},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/hippocampal-atrophy-as-a-quantitative-trait-in-a-genome-wide-19668339","doi":"10.1371/journal.pone.0006501","journal":"PloS one","n_participants":381,"pmid":"19668339","source_url":"https://pubmed.ncbi.nlm.nih.gov/19668339/","study_design":"case-control study","title":"Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease","title_match":false,"year":2009},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/cell-subtype-specific-effects-of-genetic-variation-in-the-alzheimer-s-38514782","doi":"10.1038/s41588-024-01685-y","journal":"Nature genetics","n_participants":424,"pmid":"38514782","source_url":"https://pubmed.ncbi.nlm.nih.gov/38514782/","study_design":null,"title":"Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain","title_match":false,"year":2024},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-genetic-architecture-of-alzheimer-s-disease-beyond-app-psens-and-20594621","doi":"10.1016/j.neurobiolaging.2010.03.025","journal":"Neurobiology of aging","n_participants":null,"pmid":"20594621","source_url":"https://pubmed.ncbi.nlm.nih.gov/20594621/","study_design":null,"title":"The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE","title_match":false,"year":2012},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/evidence-for-novel-susceptibility-genes-for-late-onset-alzheimer-s-17317784","doi":"10.1093/hmg/ddm031","journal":"Human molecular genetics","n_participants":null,"pmid":"17317784","source_url":"https://pubmed.ncbi.nlm.nih.gov/17317784/","study_design":"meta-analysis","title":"Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants","title_match":false,"year":2007},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-apoe-levels-an-endophenotype-for-genetic-studies-22821396","doi":"10.1093/hmg/dds296","journal":"Human molecular genetics","n_participants":641,"pmid":"22821396","source_url":"https://pubmed.ncbi.nlm.nih.gov/22821396/","study_design":null,"title":"Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/accumulation-of-amyloid-precursor-protein-in-the-mitochondrial-import-16943564","doi":"10.1523/jneurosci.1469-06.2006","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"16943564","source_url":"https://pubmed.ncbi.nlm.nih.gov/16943564/","study_design":null,"title":"Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction","title_match":false,"year":2006},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/a-transcriptomic-atlas-of-aged-human-microglia-29416036","doi":"10.1038/s41467-018-02926-5","journal":"Nature communications","n_participants":null,"pmid":"29416036","source_url":"https://pubmed.ncbi.nlm.nih.gov/29416036/","study_design":null,"title":"A transcriptomic atlas of aged human microglia","title_match":false,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/cholesterol-and-matrisome-pathways-dysregulated-in-astrocytes-and-35750033","doi":"10.1016/j.cell.2022.05.017","journal":"Cell","n_participants":null,"pmid":"35750033","source_url":"https://pubmed.ncbi.nlm.nih.gov/35750033/","study_design":null,"title":"Cholesterol and matrisome pathways dysregulated in astrocytes and microglia","title_match":false,"year":2022},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/selective-removal-of-astrocytic-apoe4-strongly-protects-against-tau-33831349","doi":"10.1016/j.neuron.2021.03.024","journal":"Neuron","n_participants":null,"pmid":"33831349","source_url":"https://pubmed.ncbi.nlm.nih.gov/33831349/","study_design":null,"title":"Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia","title_match":true,"year":2021},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/age-specific-and-sex-specific-prevalence-of-cerebral-amyloidosis-28456479","doi":"10.1016/s1474-4422(17)30077-7","journal":"The Lancet. Neurology","n_participants":435,"pmid":"28456479","source_url":"https://pubmed.ncbi.nlm.nih.gov/28456479/","study_design":null,"title":"Age-specific and sex-specific prevalence of cerebral \u03b2-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50-95 years: a cross-sectional study","title_match":false,"year":2017},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/sex-mediates-relationships-between-regional-tau-pathology-and-32799367","doi":"10.1002/ana.25878","journal":"Annals of neurology","n_participants":55,"pmid":"32799367","source_url":"https://pubmed.ncbi.nlm.nih.gov/32799367/","study_design":null,"title":"Sex Mediates Relationships Between Regional Tau Pathology and Cognitive Decline","title_match":false,"year":2020},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/tau-accumulation-in-clinically-normal-older-adults-is-associated-with-30482786","doi":"10.1523/jneurosci.1397-18.2018","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":120,"pmid":"30482786","source_url":"https://pubmed.ncbi.nlm.nih.gov/30482786/","study_design":null,"title":"Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity","title_match":false,"year":2019},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/effect-of-apoe-4-genotype-on-amyloid-and-tau-accumulation-in-33129364","doi":"10.1186/s13195-020-00710-6","journal":"Alzheimer's research & therapy","n_participants":272,"pmid":"33129364","source_url":"https://pubmed.ncbi.nlm.nih.gov/33129364/","study_design":"longitudinal study","title":"Effect of APOE \u03b54 genotype on amyloid-\u03b2 and tau accumulation in Alzheimer's disease","title_match":true,"year":2020},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/predicting-future-rates-of-tau-accumulation-on-pet-33094327","doi":"10.1093/brain/awaa248","journal":"Brain : a journal of neurology","n_participants":203,"pmid":"33094327","source_url":"https://pubmed.ncbi.nlm.nih.gov/33094327/","study_design":null,"title":"Predicting future rates of tau accumulation on PET","title_match":false,"year":2020},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/menopause-status-moderates-sex-differences-in-tau-burden-a-framingham-35471588","doi":"10.1002/ana.26382","journal":"Annals of neurology","n_participants":null,"pmid":"35471588","source_url":"https://pubmed.ncbi.nlm.nih.gov/35471588/","study_design":null,"title":"Menopause Status Moderates Sex Differences in Tau Burden: A Framingham PET Study","title_match":false,"year":2022},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/apoe4-allele-disrupts-resting-state-fmri-connectivity-in-the-absence-21159973","doi":"10.1523/jneurosci.3987-10.2010","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":100,"pmid":"21159973","source_url":"https://pubmed.ncbi.nlm.nih.gov/21159973/","study_design":"longitudinal study","title":"APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF A\u03b242","title_match":true,"year":2010},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/comparing-positron-emission-tomography-imaging-and-cerebrospinal-23536396","doi":"10.1002/ana.23908","journal":"Annals of neurology","n_participants":374,"pmid":"23536396","source_url":"https://pubmed.ncbi.nlm.nih.gov/23536396/","study_design":"cross-sectional","title":"Comparing positron emission tomography imaging and cerebrospinal fluid measurements of \u03b2-amyloid","title_match":false,"year":2013},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/longitudinal-association-of-amyloid-beta-and-anxious-depressive-29325447","doi":"10.1176/appi.ajp.2017.17040442","journal":"The American journal of psychiatry","n_participants":270,"pmid":"29325447","source_url":"https://pubmed.ncbi.nlm.nih.gov/29325447/","study_design":"longitudinal study","title":"Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults","title_match":false,"year":2018},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/exercise-and-alzheimer-s-disease-biomarkers-in-cognitively-normal-20818789","doi":"10.1002/ana.22096","journal":"Annals of neurology","n_participants":56,"pmid":"20818789","source_url":"https://pubmed.ncbi.nlm.nih.gov/20818789/","study_design":null,"title":"Exercise and Alzheimer's disease biomarkers in cognitively normal older adults","title_match":false,"year":2010},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/pib-is-a-non-specific-imaging-marker-of-amyloid-beta-abeta-peptide-17698496","doi":"10.1093/brain/awm191","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"17698496","source_url":"https://pubmed.ncbi.nlm.nih.gov/17698496/","study_design":null,"title":"PIB is a non-specific imaging marker of amyloid-beta (Abeta) peptide-related cerebral amyloidosis","title_match":false,"year":2007},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/tdp-43-is-a-key-player-in-the-clinical-features-associated-with-24659241","doi":"10.1007/s00401-014-1269-z","journal":"Acta neuropathologica","n_participants":null,"pmid":"24659241","source_url":"https://pubmed.ncbi.nlm.nih.gov/24659241/","study_design":null,"title":"TDP-43 is a key player in the clinical features associated with Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-allele-dependent-pathogenesis-a-model-for-age-16079201","doi":"10.1073/pnas.0503015102","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"16079201","source_url":"https://pubmed.ncbi.nlm.nih.gov/16079201/","study_design":null,"title":"Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration","title_match":false,"year":2005},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-path-forward-in-alzheimer-s-disease-therapeutics-reevaluating-the-31706733","doi":"10.1016/j.jalz.2019.09.075","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"31706733","source_url":"https://pubmed.ncbi.nlm.nih.gov/31706733/","study_design":"clinical trial","title":"The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis","title_match":false,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/neurotoxic-soluble-amyloid-oligomers-drive-alzheimer-s-pathogenesis-34198582","doi":"10.3390/ijms22126355","journal":"International journal of molecular sciences","n_participants":null,"pmid":"34198582","source_url":"https://pubmed.ncbi.nlm.nih.gov/34198582/","study_design":null,"title":"Neurotoxic Soluble Amyloid Oligomers Drive Alzheimer's Pathogenesis and Represent a Clinically Validated Target for Slowing Disease Progression","title_match":false,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/anti-amyloid-therapy-protects-against-retinal-pigmented-epithelium-21690377","doi":"10.1073/pnas.1100901108","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"21690377","source_url":"https://pubmed.ncbi.nlm.nih.gov/21690377/","study_design":null,"title":"Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration","title_match":false,"year":2011},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/aducanumab-appropriate-use-recommendations-update-35542993","doi":"10.14283/jpad.2022.34","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"35542993","source_url":"https://pubmed.ncbi.nlm.nih.gov/35542993/","study_design":null,"title":"Aducanumab: Appropriate Use Recommendations Update","title_match":false,"year":2022},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/fatal-iatrogenic-cerebral-amyloid-related-arteritis-in-a-woman-38086820","doi":"10.1038/s41467-023-43933-5","journal":"Nature communications","n_participants":null,"pmid":"38086820","source_url":"https://pubmed.ncbi.nlm.nih.gov/38086820/","study_design":"randomized controlled trial","title":"Fatal iatrogenic cerebral \u03b2-amyloid-related arteritis in a woman treated with lecanemab for Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/amyloid-pet-imaging-in-self-identified-non-hispanic-black-33568538","doi":"10.1212/wnl.0000000000011599","journal":"Neurology","n_participants":null,"pmid":"33568538","source_url":"https://pubmed.ncbi.nlm.nih.gov/33568538/","study_design":null,"title":"Amyloid PET Imaging in Self-Identified Non-Hispanic Black Participants of the Anti-Amyloid in Asymptomatic Alzheimer's Disease (A4) Study","title_match":false,"year":2021},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/apoe-immunotherapy-reduces-cerebral-amyloid-angiopathy-and-amyloid-33597265","doi":"10.1126/scitranslmed.abd7522","journal":"Science translational medicine","n_participants":null,"pmid":"33597265","source_url":"https://pubmed.ncbi.nlm.nih.gov/33597265/","study_design":null,"title":"APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function","title_match":false,"year":2021},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/aria-in-patients-treated-with-lecanemab-ban2401-in-a-phase-2-study-in-36949897","doi":"10.1002/trc2.12377","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":null,"pmid":"36949897","source_url":"https://pubmed.ncbi.nlm.nih.gov/36949897/","study_design":"clinical trial","title":"ARIA in patients treated with lecanemab (BAN2401) in a phase 2 study in early Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/clinical-development-of-aducanumab-an-anti-a-human-monoclonal-29181491","doi":"10.14283/jpad.2017.39","journal":"The journal of prevention of Alzheimer's disease","n_participants":196,"pmid":"29181491","source_url":"https://pubmed.ncbi.nlm.nih.gov/29181491/","study_design":null,"title":"Clinical Development of Aducanumab, an Anti-A\u03b2 Human Monoclonal Antibody Being Investigated for the Treatment of Early Alzheimer's Disease","title_match":false,"year":2017},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/efficacy-and-safety-of-anti-amyloid-monoclonal-antibodies-in-current-37423541","doi":"10.1016/j.arr.2023.102012","journal":"Ageing research reviews","n_participants":14980,"pmid":"37423541","source_url":"https://pubmed.ncbi.nlm.nih.gov/37423541/","study_design":"meta-analysis","title":"Efficacy and safety of anti-amyloid-\u03b2 monoclonal antibodies in current Alzheimer's disease phase III clinical trials: A systematic review and interactive web app-based meta-analysis","title_match":false,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/donanemab-population-pharmacokinetics-amyloid-plaque-reduction-and-36805552","doi":"10.1002/cpt.2875","journal":"Clinical pharmacology and therapeutics","n_participants":null,"pmid":"36805552","source_url":"https://pubmed.ncbi.nlm.nih.gov/36805552/","study_design":null,"title":"Donanemab Population Pharmacokinetics, Amyloid Plaque Reduction, and Safety in Participants with Alzheimer's Disease","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/amyloid-related-imaging-abnormalities-haemosiderin-aria-h-in-patients-25669746","doi":"10.1136/jnnp-2014-309493","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":262,"pmid":"25669746","source_url":"https://pubmed.ncbi.nlm.nih.gov/25669746/","study_design":"open-label trial","title":"Amyloid-related imaging abnormalities-haemosiderin (ARIA-H) in patients with Alzheimer's disease treated with bapineuzumab: a historical, prospective secondary analysis","title_match":false,"year":2016},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/three-major-effects-of-apoe-4-on-a-immunotherapy-induced-aria-38756535","doi":"10.3389/fnagi.2024.1412006","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"38756535","source_url":"https://pubmed.ncbi.nlm.nih.gov/38756535/","study_design":null,"title":"Three major effects of APOE \u03b54 on A\u03b2 immunotherapy induced ARIA","title_match":true,"year":2024},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/a-immunotherapy-for-alzheimer-s-disease-effects-on-apoe-and-cerebral-25195061","doi":"10.1007/s00401-014-1340-9","journal":"Acta neuropathologica","n_participants":null,"pmid":"25195061","source_url":"https://pubmed.ncbi.nlm.nih.gov/25195061/","study_design":null,"title":"A\u03b2 immunotherapy for Alzheimer's disease: effects on apoE and cerebral vasculopathy","title_match":false,"year":2014},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/lecanemab-for-early-alzheimer-s-disease-appropriate-use-40011173","doi":"10.1016/j.tjpad.2025.100094","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"40011173","source_url":"https://pubmed.ncbi.nlm.nih.gov/40011173/","study_design":null,"title":"Lecanemab for early Alzheimer's disease: Appropriate use recommendations from the French federation of memory clinics","title_match":false,"year":2025},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/implications-of-the-approval-of-lecanemab-for-alzheimer-disease-37295957","doi":"10.1212/wnl.0000000000207438","journal":"Neurology","n_participants":null,"pmid":"37295957","source_url":"https://pubmed.ncbi.nlm.nih.gov/37295957/","study_design":"clinical trial","title":"Implications of the Approval of Lecanemab for Alzheimer Disease Patient Care: Incremental Step or Paradigm Shift?","title_match":false,"year":2023},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/effects-of-oral-alz-801-valiltramiprosate-on-plasma-biomarkers-brain-38902571","doi":"10.1007/s40265-024-02067-8","journal":"Drugs","n_participants":80,"pmid":"38902571","source_url":"https://pubmed.ncbi.nlm.nih.gov/38902571/","study_design":"clinical trial","title":"Effects of Oral ALZ-801/Valiltramiprosate on Plasma Biomarkers, Brain Hippocampal Volume, and Cognition: Results of 2-Year Single-Arm, Open-Label, Phase 2 Trial in APOE4 Carriers with Early Alzheimer's Disease","title_match":true,"year":2024},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/monoclonal-therapy-with-lecanemab-in-the-treatment-of-mild-alzheimer-39638097","doi":"10.1016/j.arr.2024.102620","journal":"Ageing research reviews","n_participants":null,"pmid":"39638097","source_url":"https://pubmed.ncbi.nlm.nih.gov/39638097/","study_design":"systematic review","title":"Monoclonal therapy with lecanemab in the treatment of mild Alzheimer's disease: A systematic review and meta-analysis","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/longitudinal-accumulation-of-cerebral-microhemorrhages-in-dominantly-33495373","doi":"10.1212/wnl.0000000000011542","journal":"Neurology","n_participants":310,"pmid":"33495373","source_url":"https://pubmed.ncbi.nlm.nih.gov/33495373/","study_design":"cross-sectional","title":"Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/spontaneous-aria-amyloid-related-imaging-abnormalities-and-cerebral-25408217","doi":"10.3233/jad-142325","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"25408217","source_url":"https://pubmed.ncbi.nlm.nih.gov/25408217/","study_design":null,"title":"Spontaneous ARIA (amyloid-related imaging abnormalities) and cerebral amyloid angiopathy related inflammation in presenilin 1-associated familial Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/anti-amyloid-monoclonal-antibodies-for-alzheimer-s-disease-evidence-41003140","doi":"10.3390/jpm15090437","journal":"Journal of personalized medicine","n_participants":null,"pmid":"41003140","source_url":"https://pubmed.ncbi.nlm.nih.gov/41003140/","study_design":null,"title":"Anti-Amyloid Monoclonal Antibodies for Alzheimer's Disease: Evidence, ARIA Risk, and Precision Patient Selection","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/prognostic-and-predictive-factors-in-early-alzheimer-s-disease-a-38405341","doi":"10.3233/adr-230045","journal":"Journal of Alzheimer's disease reports","n_participants":null,"pmid":"38405341","source_url":"https://pubmed.ncbi.nlm.nih.gov/38405341/","study_design":null,"title":"Prognostic and Predictive Factors in Early Alzheimer's Disease: A Systematic Review","title_match":false,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/population-pharmacokinetics-and-exposure-response-analyses-of-safety-39207112","doi":"10.1002/psp4.13224","journal":"CPT: pharmacometrics & systems pharmacology","n_participants":2641,"pmid":"39207112","source_url":"https://pubmed.ncbi.nlm.nih.gov/39207112/","study_design":null,"title":"Population pharmacokinetics and exposure-response analyses of safety (ARIA-E and isolated ARIA-H) of lecanemab in subjects with early Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":83,"alzhub_url":"https://alzhub.org/study/the-efficacy-and-safety-of-anti-amyloid-monoclonal-antibody-versus-40316479","doi":"10.1016/j.tjpad.2025.100195","journal":"The journal of prevention of Alzheimer's disease","n_participants":8010,"pmid":"40316479","source_url":"https://pubmed.ncbi.nlm.nih.gov/40316479/","study_design":"randomized controlled trial","title":"The efficacy and safety of anti-amyloid monoclonal antibody versus acetylcholinesterase inhibitor with an in-depth analysis across genotypes and disease stages: a systematic review and meta-analysis","title_match":false,"year":2025},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/clinical-pharmacokinetics-of-oral-alz-801-valiltramiprosate-in-a-2-39907966","doi":"10.1007/s40262-025-01482-8","journal":"Clinical pharmacokinetics","n_participants":24,"pmid":"39907966","source_url":"https://pubmed.ncbi.nlm.nih.gov/39907966/","study_design":"longitudinal study","title":"Clinical Pharmacokinetics of Oral ALZ-801/Valiltramiprosate in a 2-Year Phase 2 Trial of APOE4 Carriers with Early Alzheimer's Disease","title_match":true,"year":2025},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/amyloid-related-imaging-abnormalities-and-other-mri-findings-in-a-36281665","doi":"10.14283/jpad.2022.56","journal":"The journal of prevention of Alzheimer's disease","n_participants":1250,"pmid":"36281665","source_url":"https://pubmed.ncbi.nlm.nih.gov/36281665/","study_design":"cross-sectional","title":"Amyloid-Related Imaging Abnormalities and Other MRI Findings in a Cognitively Unimpaired Population With and Without Cerebral Amyloid","title_match":false,"year":2022},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/lecanemab-treatment-for-alzheimer-s-disease-of-varying-severities-and-41070709","doi":"10.1002/alz.70750","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":68,"pmid":"41070709","source_url":"https://pubmed.ncbi.nlm.nih.gov/41070709/","study_design":"cohort study","title":"Lecanemab treatment for Alzheimer's Disease of varying severities and associated plasma biomarkers monitoring: A multi-center real-world study in China","title_match":false,"year":2025},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/greater-white-matter-hyperintensity-volume-is-associated-with-the-39044495","doi":"10.14283/jpad.2024.139","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"39044495","source_url":"https://pubmed.ncbi.nlm.nih.gov/39044495/","study_design":"longitudinal study","title":"Greater White Matter Hyperintensity Volume Is Associated with the Number of Microhemorrhages in Preclinical Alzheimer's Disease","title_match":false,"year":2024},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/initial-experiences-with-amyloid-related-imaging-abnormalities-in-37874098","doi":"10.14283/jpad.2023.96","journal":"The journal of prevention of Alzheimer's disease","n_participants":24,"pmid":"37874098","source_url":"https://pubmed.ncbi.nlm.nih.gov/37874098/","study_design":null,"title":"Initial Experiences with Amyloid-Related Imaging Abnormalities in Patients Receiving Aducanumab Following Accelerated Approval","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/two-cases-of-amyloid-related-imaging-abnormalities-aria-following-40624486","doi":"10.1186/s12883-025-04302-5","journal":"BMC neurology","n_participants":null,"pmid":"40624486","source_url":"https://pubmed.ncbi.nlm.nih.gov/40624486/","study_design":null,"title":"Two cases of Amyloid-Related Imaging Abnormalities (ARIA) following lecanemab treatment for alzheimer's disease and a literature review","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/review-of-anti-amyloid-beta-a-monoclonal-antibodies-for-the-treatment-40940304","doi":"10.1080/17512433.2025.2556122","journal":"Expert review of clinical pharmacology","n_participants":null,"pmid":"40940304","source_url":"https://pubmed.ncbi.nlm.nih.gov/40940304/","study_design":null,"title":"Review of anti-amyloid-beta (A\u03b2) monoclonal antibodies for the treatment of Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":84,"alzhub_url":"https://alzhub.org/study/japanese-subgroup-analyses-from-emerge-and-engage-phase-3-clinical-39350371","doi":"10.14283/jpad.2024.106","journal":"The journal of prevention of Alzheimer's disease","n_participants":121,"pmid":"39350371","source_url":"https://pubmed.ncbi.nlm.nih.gov/39350371/","study_design":"clinical trial","title":"Japanese Subgroup Analyses from EMERGE and ENGAGE, Phase 3 Clinical Trials of Aducanumab in Patients with Early Alzheimer's Disease","title_match":false,"year":2024},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/efficacy-and-apoe-4-stratified-risk-of-donanemab-in-alzheimer-s-40692324","doi":"10.1177/13872877251361044","journal":"Journal of Alzheimer's disease : JAD","n_participants":2054,"pmid":"40692324","source_url":"https://pubmed.ncbi.nlm.nih.gov/40692324/","study_design":"systematic review","title":"Efficacy and APOE \u03b54-stratified risk of donanemab in Alzheimer's disease: A systematic review and meta-analysis of randomized clinical trials","title_match":true,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/apoe-4-allele-s-associated-adverse-events-reported-from-placebo-arm-39081988","doi":"10.3389/frdem.2023.1320329","journal":"Frontiers in dementia","n_participants":6313,"pmid":"39081988","source_url":"https://pubmed.ncbi.nlm.nih.gov/39081988/","study_design":null,"title":"APOE -\u03b54 allele[s]-associated adverse events reported from placebo arm in clinical trials for Alzheimer's disease: implications for anti-amyloid beta therapy","title_match":true,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/fda-approved-passive-immunization-treatments-against-a-in-alzheimer-s-41596530","doi":"10.3390/ijms27020883","journal":"International journal of molecular sciences","n_participants":null,"pmid":"41596530","source_url":"https://pubmed.ncbi.nlm.nih.gov/41596530/","study_design":null,"title":"FDA-Approved Passive Immunization Treatments Against A\u03b2 in Alzheimer's Disease: Where Are We Now?","title_match":false,"year":2026},{"alzhub_score":81,"alzhub_url":"https://alzhub.org/study/influence-of-patient-characteristics-on-efficacy-and-safety-of-anti-41352683","doi":"10.1016/j.arr.2025.102981","journal":"Ageing research reviews","n_participants":5633,"pmid":"41352683","source_url":"https://pubmed.ncbi.nlm.nih.gov/41352683/","study_design":"systematic review","title":"Influence of patient characteristics on efficacy and safety of anti-amyloid monoclonal antibodies in Alzheimer's disease: A systematic review and meta-analysis","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/advances-of-therapeutic-strategies-for-alzheimer-s-disease-41107537","doi":"10.1007/s00415-025-13456-8","journal":"Journal of neurology","n_participants":null,"pmid":"41107537","source_url":"https://pubmed.ncbi.nlm.nih.gov/41107537/","study_design":null,"title":"Advances of therapeutic strategies for Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/predicting-severity-of-cerebral-amyloid-angiopathy-neuropathology-a-41057989","doi":"10.1002/alz.70057","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"41057989","source_url":"https://pubmed.ncbi.nlm.nih.gov/41057989/","study_design":null,"title":"Predicting severity of cerebral amyloid angiopathy neuropathology: A modeling approach using NACC and ROSMAP data","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/a-novel-biochemical-analysis-for-apoe4-quantification-in-plasma-and-40671162","doi":"10.1186/s13195-025-01811-w","journal":"Alzheimer's research & therapy","n_participants":160,"pmid":"40671162","source_url":"https://pubmed.ncbi.nlm.nih.gov/40671162/","study_design":null,"title":"A novel biochemical analysis for ApoE4 quantification in plasma and discrimination of homozygous and heterozygous APOE \u03b54 carriers","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/anti-amyloid-monoclonal-antibody-therapies-in-alzheimer-s-disease-a-41077117","doi":"10.1016/j.neuroscience.2025.10.011","journal":"Neuroscience","n_participants":null,"pmid":"41077117","source_url":"https://pubmed.ncbi.nlm.nih.gov/41077117/","study_design":null,"title":"Anti-amyloid monoclonal antibody therapies in Alzheimer's disease - a scoping review","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/imaging-of-amyloid-related-imaging-abnormalities-aria-37995736","doi":"10.1055/a-2185-8472","journal":"RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin","n_participants":null,"pmid":"37995736","source_url":"https://pubmed.ncbi.nlm.nih.gov/37995736/","study_design":null,"title":"Imaging of Amyloid-Related Imaging Abnormalities (ARIA)","title_match":false,"year":2024},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/amyloid-related-imaging-abnormalities-aria-in-alzheimer-s-disease-41904593","doi":"10.1186/s13195-026-02022-7","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"41904593","source_url":"https://pubmed.ncbi.nlm.nih.gov/41904593/","study_design":null,"title":"Amyloid-related imaging abnormalities (ARIA) in Alzheimer's disease: from pathophysiology to individualized risk assessment","title_match":false,"year":2026},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/real-world-experience-with-baseline-characteristics-and-safety-of-41396015","doi":"10.1177/13872877251406619","journal":"Journal of Alzheimer's disease : JAD","n_participants":190,"pmid":"41396015","source_url":"https://pubmed.ncbi.nlm.nih.gov/41396015/","study_design":null,"title":"Real-world experience with baseline characteristics and safety of lecanemab for Alzheimer's disease in Eastern China","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/amyloid-beta-peptide-and-tau-protein-crosstalk-in-alzheimer-s-disease-35017413","doi":"10.4103/1673-5374.332127","journal":"Neural regeneration research","n_participants":null,"pmid":"35017413","source_url":"https://pubmed.ncbi.nlm.nih.gov/35017413/","study_design":null,"title":"Amyloid-beta peptide and tau protein crosstalk in Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neuronal-apoptosis-by-apolipoprotein-e4-through-low-density-11069947","doi":"10.1523/jneurosci.20-22-08401.2000","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"11069947","source_url":"https://pubmed.ncbi.nlm.nih.gov/11069947/","study_design":null,"title":"Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases","title_match":true,"year":2000},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/link-between-type-2-diabetes-and-alzheimer-s-disease-from-25792818","doi":"10.2147/cia.s74042","journal":"Clinical interventions in aging","n_participants":null,"pmid":"25792818","source_url":"https://pubmed.ncbi.nlm.nih.gov/25792818/","study_design":null,"title":"Link between type 2 diabetes and Alzheimer's disease: from epidemiology to mechanism and treatment","title_match":false,"year":2015},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/rosiglitazone-monotherapy-in-mild-to-moderate-alzheimer-s-disease-20733306","doi":"10.1159/000318845","journal":"Dementia and geriatric cognitive disorders","n_participants":693,"pmid":"20733306","source_url":"https://pubmed.ncbi.nlm.nih.gov/20733306/","study_design":"open-label trial","title":"Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study","title_match":false,"year":2010},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/evidence-for-benefit-of-statins-to-modify-cognitive-decline-and-risk-28212683","doi":"10.1186/s13195-017-0237-y","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"28212683","source_url":"https://pubmed.ncbi.nlm.nih.gov/28212683/","study_design":null,"title":"Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/study-of-the-ketogenic-agent-ac-1202-in-mild-to-moderate-alzheimer-s-19664276","doi":"10.1186/1743-7075-6-31","journal":"Nutrition & metabolism","n_participants":55,"pmid":"19664276","source_url":"https://pubmed.ncbi.nlm.nih.gov/19664276/","study_design":null,"title":"Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial","title_match":false,"year":2009},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/disclosure-of-apoe-genotype-for-risk-of-alzheimer-s-disease-19605829","doi":"10.1056/nejmoa0809578","journal":"The New England journal of medicine","n_participants":null,"pmid":"19605829","source_url":"https://pubmed.ncbi.nlm.nih.gov/19605829/","study_design":null,"title":"Disclosure of APOE genotype for risk of Alzheimer's disease","title_match":false,"year":2009},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/cognitive-activity-and-incident-ad-in-a-population-based-sample-of-12499482","doi":"10.1212/01.wnl.0000036905.59156.a1","journal":"Neurology","n_participants":139,"pmid":"12499482","source_url":"https://pubmed.ncbi.nlm.nih.gov/12499482/","study_design":null,"title":"Cognitive activity and incident AD in a population-based sample of older persons","title_match":false,"year":2002},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/physical-activity-and-amyloid-plasma-and-brain-levels-results-from-22889922","doi":"10.1038/mp.2012.107","journal":"Molecular psychiatry","n_participants":116,"pmid":"22889922","source_url":"https://pubmed.ncbi.nlm.nih.gov/22889922/","study_design":null,"title":"Physical activity and amyloid-\u03b2 plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing","title_match":false,"year":2013},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/red-blood-cell-3-fatty-acid-levels-and-markers-of-accelerated-brain-22371413","doi":"10.1212/wnl.0b013e318249f6a9","journal":"Neurology","n_participants":1575,"pmid":"22371413","source_url":"https://pubmed.ncbi.nlm.nih.gov/22371413/","study_design":"cross-sectional","title":"Red blood cell \u03c9-3 fatty acid levels and markers of accelerated brain aging","title_match":false,"year":2012},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/physical-activity-brain-volume-and-dementia-risk-the-framingham-study-27422439","doi":"10.1093/gerona/glw130","journal":"The journals of gerontology. Series A, Biological sciences and medical sciences","n_participants":3714,"pmid":"27422439","source_url":"https://pubmed.ncbi.nlm.nih.gov/27422439/","study_design":"longitudinal study","title":"Physical Activity, Brain Volume, and Dementia Risk: The Framingham Study","title_match":false,"year":2017},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/observed-hearing-loss-and-incident-dementia-in-a-multiethnic-cohort-28323321","doi":"10.1111/jgs.14848","journal":"Journal of the American Geriatrics Society","n_participants":1881,"pmid":"28323321","source_url":"https://pubmed.ncbi.nlm.nih.gov/28323321/","study_design":"cohort study","title":"Observed Hearing Loss and Incident Dementia in a Multiethnic Cohort","title_match":false,"year":2017},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/urban-air-pollution-influences-on-olfactory-function-and-pathology-in-19297138","doi":"10.1016/j.etp.2009.02.117","journal":"Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie","n_participants":null,"pmid":"19297138","source_url":"https://pubmed.ncbi.nlm.nih.gov/19297138/","study_design":null,"title":"Urban air pollution: influences on olfactory function and pathology in exposed children and young adults","title_match":false,"year":2010},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neuroinflammation-hyperphosphorylated-tau-diffuse-amyloid-plaques-and-21955814","doi":"10.3233/jad-2011-110722","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"21955814","source_url":"https://pubmed.ncbi.nlm.nih.gov/21955814/","study_design":null,"title":"Neuroinflammation, hyperphosphorylated tau, diffuse amyloid plaques, and down-regulation of the cellular prion protein in air pollution exposed children and young adults","title_match":false,"year":2012},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/hallmarks-of-alzheimer-disease-are-evolving-relentlessly-in-29587223","doi":"10.1016/j.envres.2018.03.023","journal":"Environmental research","n_participants":null,"pmid":"29587223","source_url":"https://pubmed.ncbi.nlm.nih.gov/29587223/","study_design":null,"title":"Hallmarks of Alzheimer disease are evolving relentlessly in Metropolitan Mexico City infants, children and young adults. APOE4 carriers have higher suicide risk and higher odds of reaching NFT stage V at \u2264 40 years of age","title_match":true,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neuronal-death-and-survival-under-oxidative-stress-in-alzheimer-and-18220780","doi":"10.2174/187152707783399201","journal":"CNS & neurological disorders drug targets","n_participants":null,"pmid":"18220780","source_url":"https://pubmed.ncbi.nlm.nih.gov/18220780/","study_design":null,"title":"Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases","title_match":false,"year":2007},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-and-alpha-synuclein-pathology-in-the-olfactory-29935448","doi":"10.1016/j.envres.2018.06.027","journal":"Environmental research","n_participants":null,"pmid":"29935448","source_url":"https://pubmed.ncbi.nlm.nih.gov/29935448/","study_design":null,"title":"Alzheimer's disease and alpha-synuclein pathology in the olfactory bulbs of infants, children, teens and adults \u2264 40 years in Metropolitan Mexico City. APOE4 carriers at higher risk of suicide accelerate their olfactory bulb pathology","title_match":true,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/interactions-between-inflammation-sex-steroids-and-alzheimer-s-27651175","doi":"10.1016/j.yfrne.2016.09.001","journal":"Frontiers in neuroendocrinology","n_participants":null,"pmid":"27651175","source_url":"https://pubmed.ncbi.nlm.nih.gov/27651175/","study_design":null,"title":"Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors","title_match":false,"year":2016},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/association-of-low-level-ozone-with-cognitive-decline-in-older-adults-29103040","doi":"10.3233/jad-170658","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"29103040","source_url":"https://pubmed.ncbi.nlm.nih.gov/29103040/","study_design":null,"title":"Association of Low-Level Ozone with Cognitive Decline in Older Adults","title_match":false,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/apoe-genotype-and-alzheimer-s-disease-the-influence-of-lifestyle-and-34275270","doi":"10.1021/acschemneuro.1c00295","journal":"ACS chemical neuroscience","n_participants":null,"pmid":"34275270","source_url":"https://pubmed.ncbi.nlm.nih.gov/34275270/","study_design":null,"title":"APOE Genotype and Alzheimer's Disease: The Influence of Lifestyle and Environmental Factors","title_match":false,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/decreases-in-short-term-memory-iq-and-altered-brain-metabolic-ratios-25633678","doi":"10.3233/jad-142685","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"25633678","source_url":"https://pubmed.ncbi.nlm.nih.gov/25633678/","study_design":null,"title":"Decreases in Short Term Memory, IQ, and Altered Brain Metabolic Ratios in Urban Apolipoprotein \u03b54 Children Exposed to Air Pollution","title_match":true,"year":2015},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-in-lipoprotein-metabolism-health-and-cardiovascular-30598326","doi":"10.1016/j.pathol.2018.11.002","journal":"Pathology","n_participants":null,"pmid":"30598326","source_url":"https://pubmed.ncbi.nlm.nih.gov/30598326/","study_design":null,"title":"Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-endotoxin-hypothesis-of-neurodegeneration-31519175","doi":"10.1186/s12974-019-1564-7","journal":"Journal of neuroinflammation","n_participants":null,"pmid":"31519175","source_url":"https://pubmed.ncbi.nlm.nih.gov/31519175/","study_design":null,"title":"The endotoxin hypothesis of neurodegeneration","title_match":false,"year":2019},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe-genotype-influences-the-gut-microbiome-structure-and-function-in-30958695","doi":"10.1096/fj.201900071r","journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","n_participants":null,"pmid":"30958695","source_url":"https://pubmed.ncbi.nlm.nih.gov/30958695/","study_design":null,"title":"APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiology","title_match":false,"year":2019},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/corroboration-of-a-major-role-for-herpes-simplex-virus-type-1-in-30405395","doi":"10.3389/fnagi.2018.00324","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"30405395","source_url":"https://pubmed.ncbi.nlm.nih.gov/30405395/","study_design":null,"title":"Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer's Disease","title_match":false,"year":2018},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/hydra-revealing-heterogeneity-of-imaging-and-genetic-patterns-through-26923371","doi":"10.1016/j.neuroimage.2016.02.041","journal":"NeuroImage","n_participants":null,"pmid":"26923371","source_url":"https://pubmed.ncbi.nlm.nih.gov/26923371/","study_design":null,"title":"HYDRA: Revealing heterogeneity of imaging and genetic patterns through a multiple max-margin discriminative analysis framework","title_match":false,"year":2017},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-alzheimer-s-disease-findings-hypotheses-and-34460318","doi":"10.1146/annurev-pathmechdis-030421-112756","journal":"Annual review of pathology","n_participants":null,"pmid":"34460318","source_url":"https://pubmed.ncbi.nlm.nih.gov/34460318/","study_design":null,"title":"Apolipoprotein E and Alzheimer's Disease: Findings, Hypotheses, and Potential Mechanisms","title_match":false,"year":2022},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-40-42-ratio-predicts-cerebral-amyloidosis-in-31113759","doi":"10.1016/j.jalz.2019.03.009","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":276,"pmid":"31113759","source_url":"https://pubmed.ncbi.nlm.nih.gov/31113759/","study_design":"cohort study","title":"Plasma amyloid \u03b2 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/gabaergic-dysfunction-neural-network-hyperactivity-and-memory-33573856","doi":"10.1016/j.semcdb.2021.01.005","journal":"Seminars in cell & developmental biology","n_participants":null,"pmid":"33573856","source_url":"https://pubmed.ncbi.nlm.nih.gov/33573856/","study_design":null,"title":"GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/experimental-and-real-world-evidence-supporting-the-computational-36172600","doi":"10.1038/s43587-021-00122-7","journal":"Nature aging","n_participants":null,"pmid":"36172600","source_url":"https://pubmed.ncbi.nlm.nih.gov/36172600/","study_design":null,"title":"Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4 -related Alzheimer's disease","title_match":true,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/endosome-function-and-dysfunction-in-alzheimer-s-disease-and-other-15639316","doi":"10.1016/j.neurobiolaging.2004.09.018","journal":"Neurobiology of aging","n_participants":null,"pmid":"15639316","source_url":"https://pubmed.ncbi.nlm.nih.gov/15639316/","study_design":null,"title":"Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases","title_match":false,"year":2005},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-and-gfap-predict-widespread-cognitive-decline-in-41402627","doi":"10.1007/s00415-025-13556-5","journal":"Journal of neurology","n_participants":136,"pmid":"41402627","source_url":"https://pubmed.ncbi.nlm.nih.gov/41402627/","study_design":null,"title":"Plasma p-Tau217 and GFAP predict widespread cognitive decline in Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":56,"alzhub_url":"https://alzhub.org/study/effectiveness-safety-and-biomarker-dynamics-of-lecanemab-in-chinese-41823189","doi":"10.1002/alz.71231","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"41823189","source_url":"https://pubmed.ncbi.nlm.nih.gov/41823189/","study_design":null,"title":"Effectiveness, safety, and biomarker dynamics of lecanemab in Chinese Alzheimer's disease population: a multicenter real-world study","title_match":false,"year":2026},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-p-tau181-and-a42-predict-amyloid-pet-positivity-in-42163294","doi":"10.1186/s13195-026-02080-x","journal":"Alzheimer's research & therapy","n_participants":1407,"pmid":"42163294","source_url":"https://pubmed.ncbi.nlm.nih.gov/42163294/","study_design":"cohort study","title":"Plasma p-tau217, p-tau181, and A\u03b242 predict amyloid PET positivity in cognitively unimpaired adults","title_match":false,"year":2026},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/plasma-phosphorylated-tau-217-and-amyloid-42-40-for-amyloid-risk-in-40775788","doi":"10.1186/s13195-025-01826-3","journal":"Alzheimer's research & therapy","n_participants":1545,"pmid":"40775788","source_url":"https://pubmed.ncbi.nlm.nih.gov/40775788/","study_design":null,"title":"Plasma phosphorylated tau 217 and amyloid\u2011\u03b2 42/40 for amyloid risk in subgroups","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/head-to-head-comparison-of-plasma-p-tau181-p-tau231-and-glial-37268240","doi":"10.1016/j.nbd.2023.106175","journal":"Neurobiology of disease","n_participants":88,"pmid":"37268240","source_url":"https://pubmed.ncbi.nlm.nih.gov/37268240/","study_design":null,"title":"Head-to-head comparison of plasma p-tau181, p-tau231 and glial fibrillary acidic protein in clinically unimpaired elderly with three levels of APOE4-related risk for Alzheimer's disease","title_match":true,"year":2023},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/csf-and-plasma-tau-biomarkers-in-the-down-syndrome-alzheimer-s-42435584","doi":"10.1016/j.ebiom.2026.106370","journal":"EBioMedicine","n_participants":461,"pmid":"42435584","source_url":"https://pubmed.ncbi.nlm.nih.gov/42435584/","study_design":"cross-sectional","title":"CSF and plasma tau biomarkers in the Down syndrome-Alzheimer's disease continuum","title_match":false,"year":2026},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/polygenic-scores-of-core-1-alzheimer-s-disease-biomarkers-predict-41307156","doi":"10.1002/alz.70937","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":515,"pmid":"41307156","source_url":"https://pubmed.ncbi.nlm.nih.gov/41307156/","study_design":"longitudinal study","title":"Polygenic scores of Core 1 Alzheimer's disease biomarkers predict early cognitive and pathological change","title_match":false,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/plasma-p-tau217-and-apoe-genotype-prodromal-alzheimer-s-disease-41809502","doi":"10.1002/dad2.70279","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"41809502","source_url":"https://pubmed.ncbi.nlm.nih.gov/41809502/","study_design":null,"title":"Plasma p-tau217 and APOE genotype: Prodromal Alzheimer's disease staging","title_match":false,"year":2026},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/day-to-day-sleep-variability-with-alzheimer-s-biomarkers-in-at-risk-38371359","doi":"10.1002/dad2.12521","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"38371359","source_url":"https://pubmed.ncbi.nlm.nih.gov/38371359/","study_design":null,"title":"Day-to-day sleep variability with Alzheimer's biomarkers in at-risk elderly","title_match":false,"year":2024},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/in-an-older-age-vascular-cohort-carotid-stenosis-is-associated-with-41249770","doi":"10.1002/alz.70893","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":182,"pmid":"41249770","source_url":"https://pubmed.ncbi.nlm.nih.gov/41249770/","study_design":null,"title":"In an older-age vascular cohort, carotid stenosis is associated with processing speed and executive function cognitive deficits, which correlate with p-tau217","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/clinical-and-demographic-factors-modify-the-association-between-39713247","doi":"10.1002/dad2.70047","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":1185,"pmid":"39713247","source_url":"https://pubmed.ncbi.nlm.nih.gov/39713247/","study_design":null,"title":"Clinical and demographic factors modify the association between plasma phosphorylated tau-181 and cognition","title_match":false,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/real-world-applicability-of-glial-fibrillary-acidic-protein-and-36072480","doi":"10.3389/fnagi.2022.887498","journal":"Frontiers in aging neuroscience","n_participants":63,"pmid":"36072480","source_url":"https://pubmed.ncbi.nlm.nih.gov/36072480/","study_design":"cross-sectional","title":"Real-world applicability of glial fibrillary acidic protein and neurofilament light chain in Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":80,"alzhub_url":"https://alzhub.org/study/central-autonomic-network-dysfunction-and-plasma-alzheimer-s-disease-38851772","doi":"10.1186/s13195-024-01486-9","journal":"Alzheimer's research & therapy","n_participants":122,"pmid":"38851772","source_url":"https://pubmed.ncbi.nlm.nih.gov/38851772/","study_design":"meta-analysis","title":"Central autonomic network dysfunction and plasma Alzheimer's disease biomarkers in older adults","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/plasma-neurodegenerative-biomarkers-in-cognitively-preserved-39571163","doi":"10.14336/ad.2024.1260","journal":"Aging and disease","n_participants":null,"pmid":"39571163","source_url":"https://pubmed.ncbi.nlm.nih.gov/39571163/","study_design":null,"title":"Plasma Neurodegenerative Biomarkers in Cognitively Preserved Nonagenarians","title_match":false,"year":2024},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/differential-associations-of-apoe-and-trem2-variants-with-glial-40659842","doi":"10.1038/s41380-025-03098-7","journal":"Molecular psychiatry","n_participants":50000,"pmid":"40659842","source_url":"https://pubmed.ncbi.nlm.nih.gov/40659842/","study_design":null,"title":"Differential associations of APOE and TREM2 variants with glial fibrillary acidic protein and neurofilament light in plasma of UK Biobank participants support distinct disease mechanisms","title_match":false,"year":2025},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/plasma-neurofilament-light-chain-in-memory-clinic-practice-evidence-36462720","doi":"10.1016/j.nbd.2022.105937","journal":"Neurobiology of disease","n_participants":558,"pmid":"36462720","source_url":"https://pubmed.ncbi.nlm.nih.gov/36462720/","study_design":"cross-sectional","title":"Plasma neurofilament light chain in memory clinic practice: Evidence from a real-life study","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/genetic-risk-and-plasma-biomarkers-of-dementia-with-lewy-bodies-in-a-40374660","doi":"10.1038/s41531-025-00988-z","journal":"NPJ Parkinson's disease","n_participants":151,"pmid":"40374660","source_url":"https://pubmed.ncbi.nlm.nih.gov/40374660/","study_design":null,"title":"Genetic risk and plasma biomarkers of dementia with Lewy bodies in a Chinese population","title_match":false,"year":2025},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/alzheimer-s-and-neurodegenerative-disease-biomarkers-in-blood-predict-38689358","doi":"10.1186/s13195-024-01459-y","journal":"Alzheimer's research & therapy","n_participants":622,"pmid":"38689358","source_url":"https://pubmed.ncbi.nlm.nih.gov/38689358/","study_design":"longitudinal study","title":"Alzheimer's and neurodegenerative disease biomarkers in blood predict brain atrophy and cognitive decline","title_match":false,"year":2024},{"alzhub_score":88,"alzhub_url":"https://alzhub.org/study/alzheimer-s-blood-based-biomarkers-incident-dementia-and-interactions-42509652","doi":"10.1002/alz.71704","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":2467,"pmid":"42509652","source_url":"https://pubmed.ncbi.nlm.nih.gov/42509652/","study_design":null,"title":"Alzheimer's blood-based biomarkers, incident dementia, and interactions with age, APOE status, and hormone therapy","title_match":false,"year":2026},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/plasma-biomarker-trajectories-impact-of-ad-genetic-risk-and-clinical-40151521","doi":"10.1002/dad2.70081","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"40151521","source_url":"https://pubmed.ncbi.nlm.nih.gov/40151521/","study_design":"longitudinal study","title":"Plasma biomarker trajectories: Impact of AD genetic risk and clinical progression","title_match":false,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/apoe-4-carrier-status-modifies-plasma-p-tau181-concentrations-in-38752508","doi":"10.1002/alz.13804","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38752508","source_url":"https://pubmed.ncbi.nlm.nih.gov/38752508/","study_design":null,"title":"APOE \u03b54 carrier status modifies plasma p-tau181 concentrations in cognitively healthy super-seniors","title_match":true,"year":2024},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/plasma-a42-40-predicts-progression-from-a-amyloid-negative-to-41478830","doi":"10.1016/j.tjpad.2025.100455","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"41478830","source_url":"https://pubmed.ncbi.nlm.nih.gov/41478830/","study_design":"cohort study","title":"Plasma A\u03b242/40 predicts progression from A\u03b2-amyloid negative to positive PET scans","title_match":false,"year":2026},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-discriminate-cerebral-amyloid-status-and-cognitive-38047367","doi":"10.2174/0115672050271523231111192725","journal":"Current Alzheimer research","n_participants":null,"pmid":"38047367","source_url":"https://pubmed.ncbi.nlm.nih.gov/38047367/","study_design":"cross-sectional","title":"Blood Biomarkers Discriminate Cerebral Amyloid Status and Cognitive Diagnosis when Collected with ACD-A Anticoagulant","title_match":false,"year":2023},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-alzheimer-s-disease-biomarker-relationships-with-incident-39989078","doi":"10.1002/alz.14629","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":290,"pmid":"39989078","source_url":"https://pubmed.ncbi.nlm.nih.gov/39989078/","study_design":null,"title":"Plasma Alzheimer's disease biomarker relationships with incident abnormal amyloid PET","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/cerebral-amyloid-angiopathy-pathogenetic-mechanisms-and-link-to-dense-18184371","doi":"10.1111/j.1601-183x.2007.00380.x","journal":"Genes, brain, and behavior","n_participants":null,"pmid":"18184371","source_url":"https://pubmed.ncbi.nlm.nih.gov/18184371/","study_design":null,"title":"Cerebral amyloid angiopathy: pathogenetic mechanisms and link to dense amyloid plaques","title_match":false,"year":2008},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-amyloid-beta-42-38-ratio-as-a-plasma-biomarker-of-early-memory-39241563","doi":"10.1016/j.neurobiolaging.2024.08.009","journal":"Neurobiology of aging","n_participants":null,"pmid":"39241563","source_url":"https://pubmed.ncbi.nlm.nih.gov/39241563/","study_design":null,"title":"The amyloid beta 42/38 ratio as a plasma biomarker of early memory deficits in cognitively unimpaired older adults","title_match":false,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/high-throughput-mass-spectrometry-assay-for-quantifying-amyloid-40-31628138","doi":"10.1373/clinchem.2018.300947","journal":"Clinical chemistry","n_participants":102,"pmid":"31628138","source_url":"https://pubmed.ncbi.nlm.nih.gov/31628138/","study_design":null,"title":"High-Throughput Mass Spectrometry Assay for Quantifying \u03b2-Amyloid 40 and 42 in Cerebrospinal Fluid","title_match":false,"year":2019},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/vascular-risk-predicts-plasma-amyloid-42-40-through-cerebral-amyloid-37021572","doi":"10.1161/strokeaha.122.041854","journal":"Stroke","n_participants":96,"pmid":"37021572","source_url":"https://pubmed.ncbi.nlm.nih.gov/37021572/","study_design":"cross-sectional","title":"Vascular Risk Predicts Plasma Amyloid \u03b2 42/40 Through Cerebral Amyloid Burden in Apolipoprotein E \u03b54 Carriers","title_match":true,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/exploring-the-effect-of-apoe-4-on-biomarkers-of-neurodegeneration-in-39025198","doi":"10.1016/j.cca.2024.119876","journal":"Clinica chimica acta; international journal of clinical chemistry","n_participants":194,"pmid":"39025198","source_url":"https://pubmed.ncbi.nlm.nih.gov/39025198/","study_design":null,"title":"Exploring the effect of APOE \u03b54 on biomarkers of neurodegeneration in Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/diagnostic-accuracy-of-blood-based-biomarker-panels-a-systematic-35360215","doi":"10.3389/fnagi.2022.683689","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"35360215","source_url":"https://pubmed.ncbi.nlm.nih.gov/35360215/","study_design":"systematic review","title":"Diagnostic Accuracy of Blood-Based Biomarker Panels: A Systematic Review","title_match":false,"year":2022},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/a-glycan-epitope-correlates-with-tau-in-serum-and-predicts-37042462","doi":"10.1002/alz.13024","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":233,"pmid":"37042462","source_url":"https://pubmed.ncbi.nlm.nih.gov/37042462/","study_design":"retrospective cohort","title":"A glycan epitope correlates with tau in serum and predicts progression to Alzheimer's disease in combination with APOE4 allele status","title_match":true,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/biological-age-acceleration-associates-with-alzheimer-s-disease-41572665","doi":"10.1002/alz.71005","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"41572665","source_url":"https://pubmed.ncbi.nlm.nih.gov/41572665/","study_design":null,"title":"Biological age acceleration associates with Alzheimer's disease plasma biomarker levels","title_match":false,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/low-serum-phosphorus-correlates-with-cerebral-a-deposition-in-29163142","doi":"10.3389/fnagi.2017.00362","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"29163142","source_url":"https://pubmed.ncbi.nlm.nih.gov/29163142/","study_design":null,"title":"Low Serum Phosphorus Correlates with Cerebral A\u03b2 Deposition in Cognitively Impaired Subjects: Results from the KBASE Study","title_match":false,"year":2017},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/a-genome-wide-association-study-of-plasma-phosphorylated-tau181-34119372","doi":"10.1016/j.neurobiolaging.2021.04.018","journal":"Neurobiology of aging","n_participants":1153,"pmid":"34119372","source_url":"https://pubmed.ncbi.nlm.nih.gov/34119372/","study_design":null,"title":"A genome-wide association study of plasma phosphorylated tau181","title_match":false,"year":2021},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/biological-age-and-age-acceleration-predict-alzheimer-s-disease-40661306","doi":"10.1101/2025.05.22.25328181","journal":"medRxiv : the preprint server for health sciences","n_participants":null,"pmid":"40661306","source_url":"https://pubmed.ncbi.nlm.nih.gov/40661306/","study_design":null,"title":"Biological Age and Age Acceleration Predict Alzheimer's Disease Plasma Biomarker Levels","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/health-related-factors-and-their-impact-on-blood-based-biomarkers-of-42733904","doi":"10.1016/j.nbas.2026.100166","journal":"Aging brain","n_participants":116,"pmid":"42733904","source_url":"https://pubmed.ncbi.nlm.nih.gov/42733904/","study_design":null,"title":"Health-related factors and their impact on blood-based biomarkers of Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/cerebral-amyloid-angiopathy-related-microbleeds-and-cerebrospinal-27802236","doi":"10.3233/jad-160651","journal":"Journal of Alzheimer's disease : JAD","n_participants":88,"pmid":"27802236","source_url":"https://pubmed.ncbi.nlm.nih.gov/27802236/","study_design":null,"title":"Cerebral Amyloid Angiopathy-Related Microbleeds and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease","title_match":false,"year":2017},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-levels-of-ykl-40-in-prodromal-alzheimer-s-disease-31794792","doi":"10.1016/j.neulet.2019.134658","journal":"Neuroscience letters","n_participants":63,"pmid":"31794792","source_url":"https://pubmed.ncbi.nlm.nih.gov/31794792/","study_design":"cross-sectional","title":"Cerebrospinal fluid levels of YKL-40 in prodromal Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/exploration-of-salient-risk-factors-involved-in-mild-cognitive-35388543","doi":"10.1111/ejn.15665","journal":"The European journal of neuroscience","n_participants":null,"pmid":"35388543","source_url":"https://pubmed.ncbi.nlm.nih.gov/35388543/","study_design":null,"title":"Exploration of salient risk factors involved in mild cognitive impairment","title_match":false,"year":2022},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/delusional-severity-is-associated-with-abnormal-texture-in-flair-mri-35624987","doi":"10.3390/brainsci12050600","journal":"Brain sciences","n_participants":24,"pmid":"35624987","source_url":"https://pubmed.ncbi.nlm.nih.gov/35624987/","study_design":"longitudinal study","title":"Delusional Severity Is Associated with Abnormal Texture in FLAIR MRI","title_match":false,"year":2022},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/a-potential-endophenotype-for-alzheimer-s-disease-cerebrospinal-fluid-26545630","doi":"10.1016/j.neurobiolaging.2015.09.009","journal":"Neurobiology of aging","n_participants":null,"pmid":"26545630","source_url":"https://pubmed.ncbi.nlm.nih.gov/26545630/","study_design":null,"title":"A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin","title_match":false,"year":2016},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/soluble-lr11-competes-with-amyloid-in-binding-to-cerebrospinal-fluid-30448281","doi":"10.1016/j.cca.2018.11.024","journal":"Clinica chimica acta; international journal of clinical chemistry","n_participants":16,"pmid":"30448281","source_url":"https://pubmed.ncbi.nlm.nih.gov/30448281/","study_design":null,"title":"Soluble LR11 competes with amyloid \u03b2 in binding to cerebrospinal fluid-high-density lipoprotein","title_match":false,"year":2019},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/associations-between-baseline-amyloid-sex-and-apoe-on-subsequent-tau-30947113","doi":"10.1016/j.neurobiolaging.2019.02.019","journal":"Neurobiology of aging","n_participants":null,"pmid":"30947113","source_url":"https://pubmed.ncbi.nlm.nih.gov/30947113/","study_design":"cross-sectional","title":"Associations between baseline amyloid, sex, and APOE on subsequent tau accumulation in cerebrospinal fluid","title_match":false,"year":2019},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/differences-between-ante-mortem-alzheimer-s-disease-biomarkers-in-36840620","doi":"10.1002/alz.12997","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":100,"pmid":"36840620","source_url":"https://pubmed.ncbi.nlm.nih.gov/36840620/","study_design":null,"title":"Differences between ante mortem Alzheimer's disease biomarkers in predicting neuropathology at autopsy","title_match":false,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/neuropathology-based-apoe-genetic-risk-score-better-quantifies-36795776","doi":"10.1002/alz.12990","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"36795776","source_url":"https://pubmed.ncbi.nlm.nih.gov/36795776/","study_design":null,"title":"Neuropathology-based APOE genetic risk score better quantifies Alzheimer's risk","title_match":false,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/decreased-cerebrospinal-fluid-acetylcholinesterase-in-patients-with-14512714","doi":"10.1159/000072803","journal":"Dementia and geriatric cognitive disorders","n_participants":17,"pmid":"14512714","source_url":"https://pubmed.ncbi.nlm.nih.gov/14512714/","study_design":null,"title":"Decreased cerebrospinal fluid acetylcholinesterase in patients with subcortical ischemic vascular dementia","title_match":false,"year":2003},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/amyloid-pathology-influences-a1-42-cerebrospinal-fluid-levels-in-23364139","doi":"10.3233/jad-122176","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"23364139","source_url":"https://pubmed.ncbi.nlm.nih.gov/23364139/","study_design":null,"title":"Amyloid pathology influences a\u03b21-42 cerebrospinal fluid levels in dementia with lewy bodies","title_match":false,"year":2013},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-cell-biology-of-apoe-in-the-brain-37805344","doi":"10.1016/j.tcb.2023.09.004","journal":"Trends in cell biology","n_participants":null,"pmid":"37805344","source_url":"https://pubmed.ncbi.nlm.nih.gov/37805344/","study_design":null,"title":"The cell biology of APOE in the brain","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe-targeted-therapeutics-for-alzheimer-s-disease-41224653","doi":"10.1523/jneurosci.1388-25.2025","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"41224653","source_url":"https://pubmed.ncbi.nlm.nih.gov/41224653/","study_design":null,"title":"APOE-Targeted Therapeutics for Alzheimer's Disease","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/amelioration-of-tau-and-apoe4-linked-glial-lipid-accumulation-and-37995685","doi":"10.1016/j.neuron.2023.10.023","journal":"Neuron","n_participants":null,"pmid":"37995685","source_url":"https://pubmed.ncbi.nlm.nih.gov/37995685/","study_design":null,"title":"Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist","title_match":true,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe-genotype-determines-cell-type-specific-pathological-landscape-of-40112813","doi":"10.1016/j.neuron.2025.02.017","journal":"Neuron","n_participants":null,"pmid":"40112813","source_url":"https://pubmed.ncbi.nlm.nih.gov/40112813/","study_design":null,"title":"APOE genotype determines cell-type-specific pathological landscape of Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/apoe4-derived-from-astrocytes-leads-to-blood-brain-barrier-impairment-34957486","doi":"10.1093/brain/awab478","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"34957486","source_url":"https://pubmed.ncbi.nlm.nih.gov/34957486/","study_design":"longitudinal study","title":"APOE4 derived from astrocytes leads to blood-brain barrier impairment","title_match":true,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/decreased-lipidated-apoe-receptor-interactions-confer-protection-39532095","doi":"10.1016/j.cell.2024.10.027","journal":"Cell","n_participants":null,"pmid":"39532095","source_url":"https://pubmed.ncbi.nlm.nih.gov/39532095/","study_design":null,"title":"Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/roles-of-apoe4-on-the-pathogenesis-in-alzheimer-s-disease-and-the-37227619","doi":"10.1007/s10571-023-01365-1","journal":"Cellular and molecular neurobiology","n_participants":null,"pmid":"37227619","source_url":"https://pubmed.ncbi.nlm.nih.gov/37227619/","study_design":null,"title":"Roles of ApoE4 on the Pathogenesis in Alzheimer's Disease and the Potential Therapeutic Approaches","title_match":true,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe-in-the-bullseye-of-neurodegenerative-diseases-impact-of-the-apoe-36153580","doi":"10.1186/s13024-022-00566-4","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"36153580","source_url":"https://pubmed.ncbi.nlm.nih.gov/36153580/","study_design":null,"title":"APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases","title_match":false,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/protective-apoe-variants-support-neuronal-function-by-effluxing-41338186","doi":"10.1016/j.neuron.2025.10.040","journal":"Neuron","n_participants":null,"pmid":"41338186","source_url":"https://pubmed.ncbi.nlm.nih.gov/41338186/","study_design":null,"title":"Protective ApoE variants support neuronal function by effluxing oxidized phospholipids","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/microglial-apoe4-more-is-less-and-less-is-more-38115077","doi":"10.1186/s13024-023-00693-6","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"38115077","source_url":"https://pubmed.ncbi.nlm.nih.gov/38115077/","study_design":null,"title":"Microglial APOE4: more is less and less is more","title_match":true,"year":2023},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/metabolomics-profiling-reveals-distinct-sex-specific-signatures-in-38676929","doi":"10.1002/alz.13851","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38676929","source_url":"https://pubmed.ncbi.nlm.nih.gov/38676929/","study_design":null,"title":"Metabolomics profiling reveals distinct, sex-specific signatures in serum and brain metabolomes in mouse models of Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/apoe4-to-apoe2-allelic-switching-in-mice-improves-alzheimer-s-disease-41219507","doi":"10.1038/s41593-025-02094-y","journal":"Nature neuroscience","n_participants":null,"pmid":"41219507","source_url":"https://pubmed.ncbi.nlm.nih.gov/41219507/","study_design":null,"title":"APOE4 to APOE2 allelic switching in mice improves Alzheimer's disease-related metabolic signatures, neuropathology and cognition","title_match":true,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apoe2-protective-mechanism-and-therapeutic-implications-for-alzheimer-33148290","doi":"10.1186/s13024-020-00413-4","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"33148290","source_url":"https://pubmed.ncbi.nlm.nih.gov/33148290/","study_design":null,"title":"APOE2: protective mechanism and therapeutic implications for Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe-from-astrocytes-restores-alzheimer-s-a-pathology-and-dam-like-39528861","doi":"10.1038/s44321-024-00162-7","journal":"EMBO molecular medicine","n_participants":null,"pmid":"39528861","source_url":"https://pubmed.ncbi.nlm.nih.gov/39528861/","study_design":null,"title":"APOE from astrocytes restores Alzheimer's A\u03b2-pathology and DAM-like responses in APOE deficient microglia","title_match":false,"year":2024},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-the-resilience-gene-28299413","doi":"10.1007/s00221-017-4941-4","journal":"Experimental brain research","n_participants":null,"pmid":"28299413","source_url":"https://pubmed.ncbi.nlm.nih.gov/28299413/","study_design":null,"title":"Apolipoprotein E: the resilience gene","title_match":false,"year":2017},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-alleles-and-motor-signs-in-older-adults-with-40943487","doi":"10.3390/ijms26178562","journal":"International journal of molecular sciences","n_participants":389,"pmid":"40943487","source_url":"https://pubmed.ncbi.nlm.nih.gov/40943487/","study_design":null,"title":"Apolipoprotein E Alleles and Motor Signs in Older Adults with Alzheimer's Dementia","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/expression-and-secretion-of-apoe-isoforms-in-astrocytes-and-microglia-33556209","doi":"10.1002/glia.23974","journal":"Glia","n_participants":null,"pmid":"33556209","source_url":"https://pubmed.ncbi.nlm.nih.gov/33556209/","study_design":null,"title":"Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/ipsc-derived-blood-brain-barrier-modeling-reveals-apoe-isoform-39394110","doi":"10.1186/s12987-024-00580-2","journal":"Fluids and barriers of the CNS","n_participants":null,"pmid":"39394110","source_url":"https://pubmed.ncbi.nlm.nih.gov/39394110/","study_design":null,"title":"iPSC-derived blood-brain barrier modeling reveals APOE isoform-dependent interactions with amyloid beta","title_match":false,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/apoe2-exacerbates-tdp-43-related-toxicity-in-the-absence-of-alzheimer-36546684","doi":"10.1002/ana.26580","journal":"Annals of neurology","n_participants":null,"pmid":"36546684","source_url":"https://pubmed.ncbi.nlm.nih.gov/36546684/","study_design":null,"title":"APOE2 Exacerbates TDP-43 Related Toxicity in the Absence of Alzheimer Pathology","title_match":false,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apoe-alleles-and-diet-in-brain-aging-and-alzheimer-s-disease-32587511","doi":"10.3389/fnagi.2020.00150","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"32587511","source_url":"https://pubmed.ncbi.nlm.nih.gov/32587511/","study_design":null,"title":"APOE Alleles and Diet in Brain Aging and Alzheimer's Disease","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-recognizes-alzheimer-s-disease-associated-3-o-37014788","doi":"10.1002/anie.202212636","journal":"Angewandte Chemie (International ed. in English)","n_participants":null,"pmid":"37014788","source_url":"https://pubmed.ncbi.nlm.nih.gov/37014788/","study_design":null,"title":"Apolipoprotein E Recognizes Alzheimer's Disease Associated 3-O Sulfation of Heparan Sulfate","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-causal-effect-between-obesity-and-apoe-gene-37686334","doi":"10.3390/ijms241713531","journal":"International journal of molecular sciences","n_participants":null,"pmid":"37686334","source_url":"https://pubmed.ncbi.nlm.nih.gov/37686334/","study_design":null,"title":"Alzheimer's Disease: Causal Effect between Obesity and APOE Gene Polymorphisms","title_match":false,"year":2023},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/interaction-between-apoe-genotype-and-diabetes-in-longevity-34092638","doi":"10.3233/jad-210125","journal":"Journal of Alzheimer's disease : JAD","n_participants":12415,"pmid":"34092638","source_url":"https://pubmed.ncbi.nlm.nih.gov/34092638/","study_design":null,"title":"Interaction Between APOE Genotype and Diabetes in Longevity","title_match":false,"year":2021},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-polymorphisms-in-andean-population-of-jujuy-argentina-38312530","doi":"10.3233/adr-230061","journal":"Journal of Alzheimer's disease reports","n_participants":76,"pmid":"38312530","source_url":"https://pubmed.ncbi.nlm.nih.gov/38312530/","study_design":null,"title":"Apolipoprotein E Polymorphisms in Andean Population of Jujuy, Argentina","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e2-stimulates-protein-synthesis-and-promotes-melanoma-37335131","doi":"10.1158/0008-5472.can-23-1252","journal":"Cancer research","n_participants":null,"pmid":"37335131","source_url":"https://pubmed.ncbi.nlm.nih.gov/37335131/","study_design":null,"title":"Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression and Metastasis","title_match":false,"year":2023},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-alzheimer-s-disease-8833436","doi":"10.1146/annurev.ne.19.030196.000413","journal":"Annual review of neuroscience","n_participants":null,"pmid":"8833436","source_url":"https://pubmed.ncbi.nlm.nih.gov/8833436/","study_design":null,"title":"Apolipoprotein E and Alzheimer's disease","title_match":false,"year":1996},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-isoform-dependent-effects-on-the-processing-of-34044125","doi":"10.1016/j.bbalip.2021.158980","journal":"Biochimica et biophysica acta. Molecular and cell biology of lipids","n_participants":null,"pmid":"34044125","source_url":"https://pubmed.ncbi.nlm.nih.gov/34044125/","study_design":null,"title":"Apolipoprotein E isoform-dependent effects on the processing of Alzheimer's amyloid-\u03b2","title_match":false,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-regulates-lipid-metabolism-and-synuclein-pathology-34453582","doi":"10.1007/s00401-021-02361-9","journal":"Acta neuropathologica","n_participants":null,"pmid":"34453582","source_url":"https://pubmed.ncbi.nlm.nih.gov/34453582/","study_design":null,"title":"Apolipoprotein E regulates lipid metabolism and \u03b1-synuclein pathology in human iPSC-derived cerebral organoids","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-in-cardiometabolic-and-neurological-health-and-36077289","doi":"10.3390/ijms23179892","journal":"International journal of molecular sciences","n_participants":null,"pmid":"36077289","source_url":"https://pubmed.ncbi.nlm.nih.gov/36077289/","study_design":null,"title":"Apolipoprotein E in Cardiometabolic and Neurological Health and Diseases","title_match":false,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-interferes-with-iapp-aggregation-and-protects-31947546","doi":"10.3390/biom10010134","journal":"Biomolecules","n_participants":null,"pmid":"31947546","source_url":"https://pubmed.ncbi.nlm.nih.gov/31947546/","study_design":null,"title":"Apolipoprotein E Interferes with IAPP Aggregation and Protects Pericytes from IAPP-Induced Toxicity","title_match":false,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/human-apolipoprotein-e-glycosylation-and-sialylation-from-structure-39169951","doi":"10.3389/fnmol.2024.1399965","journal":"Frontiers in molecular neuroscience","n_participants":null,"pmid":"39169951","source_url":"https://pubmed.ncbi.nlm.nih.gov/39169951/","study_design":null,"title":"Human apolipoprotein E glycosylation and sialylation: from structure to function","title_match":false,"year":2024},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-isoforms-differentially-regulate-matrix-32758917","doi":"10.1016/j.neurobiolaging.2020.06.018","journal":"Neurobiology of aging","n_participants":null,"pmid":"32758917","source_url":"https://pubmed.ncbi.nlm.nih.gov/32758917/","study_design":null,"title":"Apolipoprotein E isoforms differentially regulate matrix metallopeptidase 9 function in Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe-genotypes-modify-the-obesity-paradox-in-dementia-37414536","doi":"10.1136/jnnp-2022-331034","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"37414536","source_url":"https://pubmed.ncbi.nlm.nih.gov/37414536/","study_design":null,"title":"APOE genotypes modify the obesity paradox in dementia","title_match":false,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/targeting-apolipoprotein-e-for-alzheimer-s-disease-an-industry-31052389","doi":"10.3390/ijms20092161","journal":"International journal of molecular sciences","n_participants":null,"pmid":"31052389","source_url":"https://pubmed.ncbi.nlm.nih.gov/31052389/","study_design":null,"title":"Targeting Apolipoprotein E for Alzheimer's Disease: An Industry Perspective","title_match":false,"year":2019},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-gene-in-synucleinopathies-a-narrative-review-38339074","doi":"10.3390/ijms25031795","journal":"International journal of molecular sciences","n_participants":null,"pmid":"38339074","source_url":"https://pubmed.ncbi.nlm.nih.gov/38339074/","study_design":"narrative review","title":"Apolipoprotein E Gene in \u03b1-Synucleinopathies: A Narrative Review","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/isoform-dependent-effects-of-apolipoprotein-e-on-sphingolipid-34958030","doi":"10.3233/jad-215205","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"34958030","source_url":"https://pubmed.ncbi.nlm.nih.gov/34958030/","study_design":null,"title":"Isoform-Dependent Effects of Apolipoprotein E on Sphingolipid Metabolism in Neural Cells","title_match":false,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/aavrh-10-mediated-apoe2-central-nervous-system-gene-therapy-for-apoe4-29409358","doi":"10.1089/humc.2017.231","journal":"Human gene therapy. Clinical development","n_participants":null,"pmid":"29409358","source_url":"https://pubmed.ncbi.nlm.nih.gov/29409358/","study_design":null,"title":"AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease","title_match":true,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/human-apolipoprotein-e-isoforms-are-differentially-sialylated-and-the-35041991","doi":"10.1016/j.nbd.2022.105631","journal":"Neurobiology of disease","n_participants":null,"pmid":"35041991","source_url":"https://pubmed.ncbi.nlm.nih.gov/35041991/","study_design":null,"title":"Human apolipoprotein E isoforms are differentially sialylated and the sialic acid moiety in ApoE2 attenuates ApoE2-A\u03b2 interaction and A\u03b2 fibrillation","title_match":false,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apoe-and-neurodegenerative-diseases-in-aging-30232753","doi":"10.1007/978-981-13-1117-8_5","journal":"Advances in experimental medicine and biology","n_participants":null,"pmid":"30232753","source_url":"https://pubmed.ncbi.nlm.nih.gov/30232753/","study_design":null,"title":"ApoE and Neurodegenerative Diseases in Aging","title_match":false,"year":2018},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/apoe2-mitigates-disease-related-phenotypes-in-an-isogenic-hipsc-based-33837271","doi":"10.1038/s41380-021-01076-3","journal":"Molecular psychiatry","n_participants":null,"pmid":"33837271","source_url":"https://pubmed.ncbi.nlm.nih.gov/33837271/","study_design":"longitudinal study","title":"APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-associated-with-reconstituted-high-density-31058310","doi":"10.1002/1873-3468.13428","journal":"FEBS letters","n_participants":null,"pmid":"31058310","source_url":"https://pubmed.ncbi.nlm.nih.gov/31058310/","study_design":null,"title":"Apolipoprotein E associated with reconstituted high-density lipoprotein-like particles is protected from aggregation","title_match":false,"year":2019},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe4-increases-energy-metabolism-in-apoe-isogenic-ipsc-derived-39056789","doi":"10.3390/cells13141207","journal":"Cells","n_participants":null,"pmid":"39056789","source_url":"https://pubmed.ncbi.nlm.nih.gov/39056789/","study_design":null,"title":"APOE4 Increases Energy Metabolism in APOE-Isogenic iPSC-Derived Neurons","title_match":true,"year":2024},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/apoe-genotypes-differentially-remodel-the-astrocytic-lipid-droplet-40894647","doi":"10.1101/2025.08.19.669163","journal":"bioRxiv : the preprint server for biology","n_participants":null,"pmid":"40894647","source_url":"https://pubmed.ncbi.nlm.nih.gov/40894647/","study_design":null,"title":"APOE genotypes differentially remodel the astrocytic lipid droplet-associated proteome to shape lipid droplet dynamics","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/interaction-between-apoe-genotype-and-diabetes-in-cognitive-decline-32211501","doi":"10.1002/dad2.12006","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"32211501","source_url":"https://pubmed.ncbi.nlm.nih.gov/32211501/","study_design":null,"title":"Interaction between APOE genotype and diabetes in cognitive decline","title_match":false,"year":2020},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/how-proteomic-apoe-serotyping-could-impact-alzheimer-s-disease-risk-24992828","doi":"10.1586/14789450.2014.936390","journal":"Expert review of proteomics","n_participants":null,"pmid":"24992828","source_url":"https://pubmed.ncbi.nlm.nih.gov/24992828/","study_design":null,"title":"How proteomic ApoE serotyping could impact Alzheimer's disease risk assessment: genetic testing by proteomics","title_match":false,"year":2014},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/molecular-recognition-of-the-interaction-between-apoe-and-the-trem2-35582645","doi":"10.1515/tnsci-2022-0218","journal":"Translational neuroscience","n_participants":null,"pmid":"35582645","source_url":"https://pubmed.ncbi.nlm.nih.gov/35582645/","study_design":null,"title":"Molecular recognition of the interaction between ApoE and the TREM2 protein","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/clearance-of-beta-amyloid-is-facilitated-by-apolipoprotein-e-and-28994390","doi":"10.7554/elife.29595","journal":"eLife","n_participants":null,"pmid":"28994390","source_url":"https://pubmed.ncbi.nlm.nih.gov/28994390/","study_design":null,"title":"Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels","title_match":false,"year":2017},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/central-and-peripheral-mechanisms-in-apoe4-driven-diabetic-pathology-32075060","doi":"10.3390/ijms21041289","journal":"International journal of molecular sciences","n_participants":null,"pmid":"32075060","source_url":"https://pubmed.ncbi.nlm.nih.gov/32075060/","study_design":null,"title":"Central and Peripheral Mechanisms in ApoE4-Driven Diabetic Pathology","title_match":true,"year":2020},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/clinical-application-of-apoe-in-alzheimer-s-prevention-a-precision-30298183","doi":"10.14283/jpad.2018.35","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"30298183","source_url":"https://pubmed.ncbi.nlm.nih.gov/30298183/","study_design":null,"title":"Clinical Application of APOE in Alzheimer's Prevention: A Precision Medicine Approach","title_match":false,"year":2018},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/role-of-apolipoprotein-e-in-alzheimer-s-disease-pathogenesis-39463215","doi":"10.24976/discov.med.202436189.179","journal":"Discovery medicine","n_participants":null,"pmid":"39463215","source_url":"https://pubmed.ncbi.nlm.nih.gov/39463215/","study_design":null,"title":"Role of Apolipoprotein E in Alzheimer's Disease Pathogenesis, Prognosis and Treatment","title_match":false,"year":2024},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/validation-of-a-novel-and-accurate-apoe4-assay-for-automated-32034174","doi":"10.1038/s41598-020-58841-7","journal":"Scientific reports","n_participants":null,"pmid":"32034174","source_url":"https://pubmed.ncbi.nlm.nih.gov/32034174/","study_design":null,"title":"Validation of a novel and accurate ApoE4 assay for automated chemistry analyzers","title_match":true,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-has-extensive-conformational-heterogeneity-in-lipid-36749730","doi":"10.1073/pnas.2215371120","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"36749730","source_url":"https://pubmed.ncbi.nlm.nih.gov/36749730/","study_design":null,"title":"Apolipoprotein E4 has extensive conformational heterogeneity in lipid-free and lipid-bound forms","title_match":true,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/interactions-between-apolipoprotein-e-metabolism-and-retinal-34210002","doi":"10.3390/life11070635","journal":"Life (Basel, Switzerland)","n_participants":null,"pmid":"34210002","source_url":"https://pubmed.ncbi.nlm.nih.gov/34210002/","study_design":null,"title":"Interactions between Apolipoprotein E Metabolism and Retinal Inflammation in Age-Related Macular Degeneration","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/quantitative-and-kinetic-proteomics-reveal-apoe-isoform-dependent-39666759","doi":"10.1371/journal.pcbi.1012407","journal":"PLoS computational biology","n_participants":null,"pmid":"39666759","source_url":"https://pubmed.ncbi.nlm.nih.gov/39666759/","study_design":null,"title":"Quantitative and Kinetic Proteomics Reveal ApoE Isoform-dependent Proteostasis Adaptations in Mouse Brain","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe-isoforms-differentially-regulates-cleavage-and-secretion-of-bdnf-28569173","doi":"10.1186/s13041-017-0301-3","journal":"Molecular brain","n_participants":null,"pmid":"28569173","source_url":"https://pubmed.ncbi.nlm.nih.gov/28569173/","study_design":null,"title":"ApoE isoforms differentially regulates cleavage and secretion of BDNF","title_match":false,"year":2017},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apoe-lipidation-as-a-therapeutic-target-in-alzheimer-s-disease-32882843","doi":"10.3390/ijms21176336","journal":"International journal of molecular sciences","n_participants":null,"pmid":"32882843","source_url":"https://pubmed.ncbi.nlm.nih.gov/32882843/","study_design":null,"title":"ApoE Lipidation as a Therapeutic Target in Alzheimer's Disease","title_match":false,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/evaluation-of-apolipoprotein-e-fragmentation-as-a-biomarker-for-29520379","doi":"10.15744/2454-4981.3.204","journal":"Journal of neurology and neurological disorders","n_participants":null,"pmid":"29520379","source_url":"https://pubmed.ncbi.nlm.nih.gov/29520379/","study_design":null,"title":"Evaluation of Apolipoprotein E Fragmentation as a Biomarker for Alzheimer's Disease","title_match":false,"year":2017},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/apoe-interacts-with-ace2-inhibiting-sars-cov-2-cellular-entry-and-35915083","doi":"10.1038/s41392-022-01118-4","journal":"Signal transduction and targeted therapy","n_participants":19,"pmid":"35915083","source_url":"https://pubmed.ncbi.nlm.nih.gov/35915083/","study_design":null,"title":"APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-genotype-affects-size-of-apoe-complexes-in-27516118","doi":"10.1093/jnen/nlw067","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"27516118","source_url":"https://pubmed.ncbi.nlm.nih.gov/27516118/","study_design":null,"title":"Apolipoprotein E Genotype Affects Size of ApoE Complexes in Cerebrospinal Fluid","title_match":false,"year":2016},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/effects-of-apoe4-and-apoe2-genotypes-on-subcortical-magnetic-34890142","doi":null,"journal":"Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing","n_participants":27535,"pmid":"34890142","source_url":"https://pubmed.ncbi.nlm.nih.gov/34890142/","study_design":null,"title":"Effects of ApoE4 and ApoE2 genotypes on subcortical magnetic susceptibility and microstructure in 27,535 participants from the UK Biobank","title_match":true,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-polymorphisms-and-female-fertility-in-a-transgenic-38982272","doi":"10.1038/s41598-024-66489-w","journal":"Scientific reports","n_participants":null,"pmid":"38982272","source_url":"https://pubmed.ncbi.nlm.nih.gov/38982272/","study_design":null,"title":"Apolipoprotein E polymorphisms and female fertility in a transgenic mouse model of Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe-genotype-and-sex-drive-microbiome-divergence-after-microbiome-41114585","doi":"10.1128/msphere.00429-25","journal":"mSphere","n_participants":null,"pmid":"41114585","source_url":"https://pubmed.ncbi.nlm.nih.gov/41114585/","study_design":null,"title":"APOE genotype and sex drive microbiome divergence after microbiome standardization in APOE-humanized mice","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/differential-and-substrate-specific-inhibition-of-secretase-by-the-c-37040764","doi":"10.1016/j.neuron.2023.03.024","journal":"Neuron","n_participants":null,"pmid":"37040764","source_url":"https://pubmed.ncbi.nlm.nih.gov/37040764/","study_design":null,"title":"Differential and substrate-specific inhibition of \u03b3-secretase by the C-terminal region of ApoE2, ApoE3, and ApoE4","title_match":true,"year":2023},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/increased-apolipoprotein-e-and-decreased-tnf-in-the-cerebrospinal-32426945","doi":"10.1002/npr2.12110","journal":"Neuropsychopharmacology reports","n_participants":28,"pmid":"32426945","source_url":"https://pubmed.ncbi.nlm.nih.gov/32426945/","study_design":null,"title":"Increased apolipoprotein E and decreased TNF-\u03b1 in the cerebrospinal fluid of nondemented APOE-\u03b54 carriers","title_match":true,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/are-apolipoprotein-e-fragments-a-promising-new-therapeutic-target-for-35321401","doi":"10.1177/20406223221081605","journal":"Therapeutic advances in chronic disease","n_participants":null,"pmid":"35321401","source_url":"https://pubmed.ncbi.nlm.nih.gov/35321401/","study_design":"narrative review","title":"Are apolipoprotein E fragments a promising new therapeutic target for Alzheimer's disease?","title_match":false,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/the-important-interface-between-apolipoprotein-e-and-32425941","doi":"10.3389/fimmu.2020.00754","journal":"Frontiers in immunology","n_participants":null,"pmid":"32425941","source_url":"https://pubmed.ncbi.nlm.nih.gov/32425941/","study_design":null,"title":"The Important Interface Between Apolipoprotein E and Neuroinflammation in Alzheimer's Disease","title_match":false,"year":2020},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/crispr-editing-of-mir-33-restores-apoe-lipidation-and-amyloid-41288387","doi":"10.1093/brain/awaf244","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"41288387","source_url":"https://pubmed.ncbi.nlm.nih.gov/41288387/","study_design":null,"title":"CRISPR editing of miR-33 restores ApoE lipidation and amyloid-\u03b2 metabolism in ApoE4 sporadic Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/common-human-genetic-variants-of-apoe-impact-murine-covid-19-mortality-36130725","doi":"10.1038/s41586-022-05344-2","journal":"Nature","n_participants":null,"pmid":"36130725","source_url":"https://pubmed.ncbi.nlm.nih.gov/36130725/","study_design":null,"title":"Common human genetic variants of APOE impact murine COVID-19 mortality","title_match":false,"year":2022},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe4-increases-susceptibility-to-stress-induced-age-dependent-34530340","doi":"10.1016/j.jpsychires.2021.09.029","journal":"Journal of psychiatric research","n_participants":null,"pmid":"34530340","source_url":"https://pubmed.ncbi.nlm.nih.gov/34530340/","study_design":null,"title":"ApoE4 increases susceptibility to stress-induced age-dependent depression-like behavior and cognitive impairment","title_match":true,"year":2021},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/the-longevity-gene-apoe2-enhances-pericyte-function-and-reduces-lipid-42744302","doi":"10.1093/brain/awag311","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"42744302","source_url":"https://pubmed.ncbi.nlm.nih.gov/42744302/","study_design":null,"title":"The longevity gene APOE2 enhances pericyte function and reduces lipid droplets","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/comparison-of-the-apoe-allelic-variants-in-the-formation-of-40962157","doi":"10.1016/j.nbd.2025.107105","journal":"Neurobiology of disease","n_participants":null,"pmid":"40962157","source_url":"https://pubmed.ncbi.nlm.nih.gov/40962157/","study_design":null,"title":"Comparison of the ApoE allelic variants in the formation of intracerebral A\u03b2 deposits","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/deciphering-apoe-genotype-driven-proteomic-and-lipidomic-alterations-38236019","doi":"10.1021/acs.jproteome.3c00604","journal":"Journal of proteome research","n_participants":null,"pmid":"38236019","source_url":"https://pubmed.ncbi.nlm.nih.gov/38236019/","study_design":null,"title":"Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer's Disease Across Distinct Brain Regions","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe-genotype-dependent-differences-in-human-astrocytic-energy-40958776","doi":"10.3389/fncel.2025.1603657","journal":"Frontiers in cellular neuroscience","n_participants":null,"pmid":"40958776","source_url":"https://pubmed.ncbi.nlm.nih.gov/40958776/","study_design":null,"title":"APOE genotype-dependent differences in human astrocytic energy metabolism","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/differential-signaling-mediated-by-apoe2-apoe3-and-apoe4-in-human-31331998","doi":"10.1523/jneurosci.2994-18.2019","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"31331998","source_url":"https://pubmed.ncbi.nlm.nih.gov/31331998/","study_design":null,"title":"Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk","title_match":true,"year":2019},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/brain-integrity-is-altered-by-hepatic-apoe-4-in-humanized-liver-mice-35418601","doi":"10.1038/s41380-022-01548-0","journal":"Molecular psychiatry","n_participants":null,"pmid":"35418601","source_url":"https://pubmed.ncbi.nlm.nih.gov/35418601/","study_design":null,"title":"Brain integrity is altered by hepatic APOE \u03b54 in humanized-liver mice","title_match":true,"year":2022},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apoe-genotype-and-stress-response-a-mini-review-27457486","doi":"10.1186/s12944-016-0288-2","journal":"Lipids in health and disease","n_participants":null,"pmid":"27457486","source_url":"https://pubmed.ncbi.nlm.nih.gov/27457486/","study_design":null,"title":"APOE genotype and stress response - a mini review","title_match":false,"year":2016},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/haptoglobin-interacts-with-apolipoprotein-e-and-beta-amyloid-and-25058565","doi":"10.1021/cn500099f","journal":"ACS chemical neuroscience","n_participants":null,"pmid":"25058565","source_url":"https://pubmed.ncbi.nlm.nih.gov/25058565/","study_design":null,"title":"Haptoglobin interacts with apolipoprotein E and beta-amyloid and influences their crosstalk","title_match":false,"year":2014},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/apoe-4-carrier-status-moderates-the-effect-of-lifestyle-factors-on-39392181","doi":"10.1002/alz.14304","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":157,"pmid":"39392181","source_url":"https://pubmed.ncbi.nlm.nih.gov/39392181/","study_design":null,"title":"APOE \u03b54 carrier status moderates the effect of lifestyle factors on cognitive reserve","title_match":true,"year":2024},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/glymphatic-distribution-of-csf-derived-apoe-into-brain-is-isoform-27931262","doi":"10.1186/s13024-016-0138-8","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"27931262","source_url":"https://pubmed.ncbi.nlm.nih.gov/27931262/","study_design":null,"title":"Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation","title_match":false,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe4-affects-basal-and-nmdar-mediated-protein-synthesis-in-neurons-34475200","doi":"10.1523/jneurosci.0435-21.2021","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"34475200","source_url":"https://pubmed.ncbi.nlm.nih.gov/34475200/","study_design":null,"title":"APOE4 Affects Basal and NMDAR-Mediated Protein Synthesis in Neurons by Perturbing Calcium Homeostasis","title_match":true,"year":2021},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-familial-dysbetalipoproteinemia-clinical-15630634","doi":"10.1055/s-2004-861492","journal":"Seminars in vascular medicine","n_participants":170,"pmid":"15630634","source_url":"https://pubmed.ncbi.nlm.nih.gov/15630634/","study_design":null,"title":"Apolipoprotein E and familial dysbetalipoproteinemia: clinical, biochemical, and genetic aspects","title_match":false,"year":2004},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/app-induced-patterned-neurodegeneration-is-exacerbated-by-apoe4-in-32580938","doi":"10.1534/g3.120.401486","journal":"G3 (Bethesda, Md.)","n_participants":null,"pmid":"32580938","source_url":"https://pubmed.ncbi.nlm.nih.gov/32580938/","study_design":null,"title":"APP-Induced Patterned Neurodegeneration Is Exacerbated by APOE4 in Caenorhabditis elegans","title_match":true,"year":2020},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-regulates-the-maturation-of-injury-induced-adult-32119690","doi":"10.1371/journal.pone.0229240","journal":"PloS one","n_participants":null,"pmid":"32119690","source_url":"https://pubmed.ncbi.nlm.nih.gov/32119690/","study_design":null,"title":"Apolipoprotein E regulates the maturation of injury-induced adult-born hippocampal neurons following traumatic brain injury","title_match":false,"year":2020},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/apoe-lipoprotein-particles-pathophysiology-therapy-and-the-crosstalk-41436721","doi":"10.1007/s12035-025-05629-3","journal":"Molecular neurobiology","n_participants":null,"pmid":"41436721","source_url":"https://pubmed.ncbi.nlm.nih.gov/41436721/","study_design":null,"title":"APOE Lipoprotein Particles: Pathophysiology, Therapy, and the Crosstalk in Alzheimer's Disease and Cardiovascular Disease","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-mediated-modulation-of-adam10-in-alzheimer-s-disease-28164773","doi":"10.2174/1567205014666170203093219","journal":"Current Alzheimer research","n_participants":null,"pmid":"28164773","source_url":"https://pubmed.ncbi.nlm.nih.gov/28164773/","study_design":null,"title":"Apolipoprotein E-mediated Modulation of ADAM10 in Alzheimer's Disease","title_match":false,"year":2017},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-genotype-modifies-the-association-between-cardiac-31364446","doi":"10.1161/jaha.118.011146","journal":"Journal of the American Heart Association","n_participants":306,"pmid":"31364446","source_url":"https://pubmed.ncbi.nlm.nih.gov/31364446/","study_design":"cross-sectional","title":"Apolipoprotein E Genotype Modifies the Association Between Cardiac Output and Cognition in Older Adults","title_match":false,"year":2019},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-risk-factor-apoe4-exerts-dimorphic-effects-on-41972397","doi":"10.1002/advs.202523511","journal":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","n_participants":null,"pmid":"41972397","source_url":"https://pubmed.ncbi.nlm.nih.gov/41972397/","study_design":null,"title":"Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone","title_match":true,"year":2026},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-from-cardiovascular-disease-to-neurodegenerative-27277824","doi":"10.1007/s00109-016-1427-y","journal":"Journal of molecular medicine (Berlin, Germany)","n_participants":null,"pmid":"27277824","source_url":"https://pubmed.ncbi.nlm.nih.gov/27277824/","study_design":null,"title":"Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders","title_match":false,"year":2016},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/apoe-genotypes-differentially-remodel-the-astrocytic-lipid-droplet-42749735","doi":"10.1038/s41467-026-76565-6","journal":"Nature communications","n_participants":null,"pmid":"42749735","source_url":"https://pubmed.ncbi.nlm.nih.gov/42749735/","study_design":null,"title":"APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-isoform-does-not-influence-trans-synaptic-spread-of-37600228","doi":"10.1177/23982128231191046","journal":"Brain and neuroscience advances","n_participants":null,"pmid":"37600228","source_url":"https://pubmed.ncbi.nlm.nih.gov/37600228/","study_design":null,"title":"Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe-is-secreted-as-a-lipid-nanoparticle-by-mammalian-cells-41134549","doi":"10.1021/acs.biochem.5c00503","journal":"Biochemistry","n_participants":null,"pmid":"41134549","source_url":"https://pubmed.ncbi.nlm.nih.gov/41134549/","study_design":null,"title":"ApoE is Secreted as a Lipid Nanoparticle by Mammalian Cells: Implications for Alzheimer's Disease Pathogenesis","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/human-apolipoprotein-e-resequencing-by-proteomic-analysis-and-its-24454848","doi":"10.1371/journal.pone.0085356","journal":"PloS one","n_participants":null,"pmid":"24454848","source_url":"https://pubmed.ncbi.nlm.nih.gov/24454848/","study_design":null,"title":"Human apolipoprotein e resequencing by proteomic analysis and its application to serotyping","title_match":false,"year":2014},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-genotype-and-neurological-disease-onset-in-niemann-23023945","doi":"10.1002/ajmg.a.35395","journal":"American journal of medical genetics. Part A","n_participants":null,"pmid":"23023945","source_url":"https://pubmed.ncbi.nlm.nih.gov/23023945/","study_design":"longitudinal study","title":"Apolipoprotein E genotype and neurological disease onset in Niemann-Pick disease, type C1","title_match":false,"year":2012},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/impact-of-apoe-genotype-on-prion-type-propagation-of-tauopathy-35440098","doi":"10.1186/s40478-022-01359-y","journal":"Acta neuropathologica communications","n_participants":null,"pmid":"35440098","source_url":"https://pubmed.ncbi.nlm.nih.gov/35440098/","study_design":null,"title":"Impact of APOE genotype on prion-type propagation of tauopathy","title_match":false,"year":2022},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/brain-targeting-liposome-based-apoe2-gene-delivery-exacerbates-39506961","doi":"10.1016/j.heliyon.2024.e39607","journal":"Heliyon","n_participants":null,"pmid":"39506961","source_url":"https://pubmed.ncbi.nlm.nih.gov/39506961/","study_design":null,"title":"Brain-targeting liposome-based APOE2 gene delivery exacerbates soluble amyloid-\u03b2 accumulation in App NL-G-F mice","title_match":false,"year":2024},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/human-apolipoprotein-e-genotype-differentially-affects-olfactory-29678753","doi":"10.1016/j.neuroscience.2018.04.009","journal":"Neuroscience","n_participants":null,"pmid":"29678753","source_url":"https://pubmed.ncbi.nlm.nih.gov/29678753/","study_design":null,"title":"Human Apolipoprotein E Genotype Differentially Affects Olfactory Behavior and Sensory Physiology in Mice","title_match":false,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/amyloid-peptide-effects-on-glucose-regulation-are-dependent-on-37163733","doi":"10.1523/eneuro.0376-22.2023","journal":"eNeuro","n_participants":null,"pmid":"37163733","source_url":"https://pubmed.ncbi.nlm.nih.gov/37163733/","study_design":null,"title":"Amyloid \u03b2-Peptide Effects on Glucose Regulation Are Dependent on Apolipoprotein E Genotype","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/impaired-cellular-copper-regulation-in-the-presence-of-apoe4-39135362","doi":"10.1111/jnc.16198","journal":"Journal of neurochemistry","n_participants":null,"pmid":"39135362","source_url":"https://pubmed.ncbi.nlm.nih.gov/39135362/","study_design":null,"title":"Impaired cellular copper regulation in the presence of ApoE4","title_match":true,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-apoe-4-status-moderates-the-relationship-between-33138883","doi":"10.1017/s1355617720001034","journal":"Journal of the International Neuropsychological Society : JINS","n_participants":null,"pmid":"33138883","source_url":"https://pubmed.ncbi.nlm.nih.gov/33138883/","study_design":null,"title":"Apolipoprotein E (APOE) \u03b54 Status Moderates the Relationship Between Close-Range Blast Exposure and Cognitive Functioning","title_match":true,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe4-exacerbates-the-senescence-of-hippocampal-neurons-and-spatial-37594184","doi":"10.1111/acel.13932","journal":"Aging cell","n_participants":null,"pmid":"37594184","source_url":"https://pubmed.ncbi.nlm.nih.gov/37594184/","study_design":null,"title":"ApoE4 exacerbates the senescence of hippocampal neurons and spatial cognitive impairment by downregulating acetyl-CoA level","title_match":true,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/exceptional-longevity-modifying-allele-apoe2-promotes-dna-signaling-42103698","doi":"10.1111/acel.70494","journal":"Aging cell","n_participants":null,"pmid":"42103698","source_url":"https://pubmed.ncbi.nlm.nih.gov/42103698/","study_design":null,"title":"Exceptional Longevity Modifying Allele APOE2 Promotes DNA Signaling Pathways Resisting Cellular Senescence in Human Neurons","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-roles-of-apolipoprotein-e-4-on-neuropathology-and-37697966","doi":"10.1111/cns.14440","journal":"CNS neuroscience & therapeutics","n_participants":null,"pmid":"37697966","source_url":"https://pubmed.ncbi.nlm.nih.gov/37697966/","study_design":null,"title":"The roles of apolipoprotein E \u03b54 on neuropathology and neuroinflammation in patients with Alzheimer's disease","title_match":true,"year":2024},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/understanding-the-role-of-apoe-fragments-in-alzheimer-s-disease-30225748","doi":"10.1007/s11064-018-2629-1","journal":"Neurochemical research","n_participants":null,"pmid":"30225748","source_url":"https://pubmed.ncbi.nlm.nih.gov/30225748/","study_design":null,"title":"Understanding the Role of ApoE Fragments in Alzheimer's Disease","title_match":false,"year":2019},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/effects-of-apoe2-and-apoe4-on-brain-microstructure-in-older-adults-38212861","doi":"10.1186/s13195-023-01380-w","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"38212861","source_url":"https://pubmed.ncbi.nlm.nih.gov/38212861/","study_design":null,"title":"Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status","title_match":true,"year":2024},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-affects-amyloid-formation-but-not-amyloid-growth-in-12000192","doi":"10.3109/13506120209072439","journal":"Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis","n_participants":null,"pmid":"12000192","source_url":"https://pubmed.ncbi.nlm.nih.gov/12000192/","study_design":null,"title":"Apolipoprotein E affects amyloid formation but not amyloid growth in vitro: mechanistic implications for apoE4 enhanced amyloid burden and risk for Alzheimer's disease","title_match":true,"year":2002},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/structural-and-functional-variations-in-human-apolipoprotein-e3-and-e4-16540478","doi":"10.1074/jbc.m511077200","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"16540478","source_url":"https://pubmed.ncbi.nlm.nih.gov/16540478/","study_design":null,"title":"Structural and functional variations in human apolipoprotein E3 and E4","title_match":false,"year":2006},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/unraveling-apoe4-s-role-in-alzheimer-s-disease-pathologies-and-39722484","doi":"10.2174/0113892037326839241014054430","journal":"Current protein & peptide science","n_participants":null,"pmid":"39722484","source_url":"https://pubmed.ncbi.nlm.nih.gov/39722484/","study_design":null,"title":"Unraveling APOE4's Role in Alzheimer's Disease: Pathologies and Therapeutic Strategies","title_match":true,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/focused-ultrasound-mediated-apoe4-knockdown-in-mouse-brain-40665471","doi":"10.1002/alz.70464","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40665471","source_url":"https://pubmed.ncbi.nlm.nih.gov/40665471/","study_design":null,"title":"Focused ultrasound-mediated APOE4 knockdown in mouse brain","title_match":true,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/when-time-s-arrow-doesn-t-bend-apoe-4-influences-episodic-memory-31473197","doi":"10.1016/j.neuropsychologia.2019.107180","journal":"Neuropsychologia","n_participants":null,"pmid":"31473197","source_url":"https://pubmed.ncbi.nlm.nih.gov/31473197/","study_design":null,"title":"When time's arrow doesn't bend: APOE-\u03b54 influences episodic memory before old age","title_match":true,"year":2019},{"alzhub_score":58,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-genetic-polymorphism-serum-lipoproteins-and-breast-10642431","doi":"10.1002/(sici)1098-2744(200001)27:1<2::aid-mc2>3.0.co;2-w","journal":"Molecular carcinogenesis","n_participants":null,"pmid":"10642431","source_url":"https://pubmed.ncbi.nlm.nih.gov/10642431/","study_design":"case-control study","title":"Apolipoprotein E genetic polymorphism, serum lipoproteins, and breast cancer risk","title_match":false,"year":2000},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe4-impairs-autophagy-and-a-clearance-by-microglial-cells-40164781","doi":"10.1007/s00011-025-02016-5","journal":"Inflammation research : official journal of the European Histamine Research Society ... [et al.]","n_participants":null,"pmid":"40164781","source_url":"https://pubmed.ncbi.nlm.nih.gov/40164781/","study_design":null,"title":"APOE4 impairs autophagy and A\u03b2 clearance by microglial cells","title_match":true,"year":2025},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/apoe-variants-in-an-iberian-alzheimer-cohort-detected-through-an-33375167","doi":"10.3390/genes12010004","journal":"Genes","n_participants":null,"pmid":"33375167","source_url":"https://pubmed.ncbi.nlm.nih.gov/33375167/","study_design":"meta-analysis","title":"APOE Variants in an Iberian Alzheimer Cohort Detected through an Optimized Sanger Sequencing Protocol","title_match":false,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe-isoforms-inhibit-amyloid-aggregation-of-proinflammatory-protein-38396791","doi":"10.3390/ijms25042114","journal":"International journal of molecular sciences","n_participants":null,"pmid":"38396791","source_url":"https://pubmed.ncbi.nlm.nih.gov/38396791/","study_design":null,"title":"ApoE Isoforms Inhibit Amyloid Aggregation of Proinflammatory Protein S100A9","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/structural-analysis-of-missense-mutations-on-the-stability-of-apoe3-41465183","doi":"10.3390/genes16121509","journal":"Genes","n_participants":null,"pmid":"41465183","source_url":"https://pubmed.ncbi.nlm.nih.gov/41465183/","study_design":null,"title":"Structural Analysis of Missense Mutations on the Stability of APOE3 and APOE4","title_match":true,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apoe-4-allele-and-csf-apoe-on-cognition-in-hiv-infected-subjects-21184197","doi":"10.1007/s11481-010-9254-3","journal":"Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology","n_participants":null,"pmid":"21184197","source_url":"https://pubmed.ncbi.nlm.nih.gov/21184197/","study_design":null,"title":"APOE \u03b5 4 allele and CSF APOE on cognition in HIV-infected subjects","title_match":true,"year":2011},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/association-of-apolipoprotein-e-gene-with-risk-cognition-and-42799898","doi":"10.1007/s00439-026-02876-9","journal":"Human genetics","n_participants":null,"pmid":"42799898","source_url":"https://pubmed.ncbi.nlm.nih.gov/42799898/","study_design":"cohort study","title":"Association of apolipoprotein E gene with risk, cognition, and prognosis of epilepsy","title_match":false,"year":2026},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-lipoprotein-particles-inhibit-amyloid-uptake-through-27151330","doi":"10.1186/s13024-016-0099-y","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"27151330","source_url":"https://pubmed.ncbi.nlm.nih.gov/27151330/","study_design":null,"title":"Apolipoprotein E lipoprotein particles inhibit amyloid-\u03b2 uptake through cell surface heparan sulphate proteoglycan","title_match":false,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/reduced-binding-of-apoe4-to-complement-factor-h-promotes-amyloid-37155564","doi":"10.15252/embr.202256467","journal":"EMBO reports","n_participants":null,"pmid":"37155564","source_url":"https://pubmed.ncbi.nlm.nih.gov/37155564/","study_design":null,"title":"Reduced binding of apoE4 to complement factor H promotes amyloid-\u03b2 oligomerization and neuroinflammation","title_match":true,"year":2023},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/plasma-apoe-proteotyping-for-apoe-4-stratification-in-the-anti-42169086","doi":"10.1186/s13195-026-02089-2","journal":"Alzheimer's research & therapy","n_participants":110,"pmid":"42169086","source_url":"https://pubmed.ncbi.nlm.nih.gov/42169086/","study_design":null,"title":"Plasma ApoE proteotyping for ApoE \u03b54 stratification in the anti-amyloid therapies era","title_match":true,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-friend-and-a-foe-50-years-of-the-apolipoprotein-e-research-trail-34672451","doi":null,"journal":"The Israel Medical Association journal : IMAJ","n_participants":null,"pmid":"34672451","source_url":"https://pubmed.ncbi.nlm.nih.gov/34672451/","study_design":null,"title":"A Friend and a Foe: 50 Years of the Apolipoprotein E Research Trail","title_match":false,"year":2021},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/molecular-insight-into-the-therapeutic-promise-of-targeting-apoe4-for-32509144","doi":"10.1155/2020/5086250","journal":"Oxidative medicine and cellular longevity","n_participants":null,"pmid":"32509144","source_url":"https://pubmed.ncbi.nlm.nih.gov/32509144/","study_design":null,"title":"Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer's Disease","title_match":true,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe-4-the-most-prevalent-yet-understudied-risk-factor-for-alzheimer-25217293","doi":"10.1016/j.jalz.2014.06.015","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"25217293","source_url":"https://pubmed.ncbi.nlm.nih.gov/25217293/","study_design":null,"title":"APOE \u03b54: the most prevalent yet understudied risk factor for Alzheimer's disease","title_match":true,"year":2014},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/plasma-oxysterols-are-associated-with-serum-lipids-and-dementia-risk-38574442","doi":"10.1002/alz.13811","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38574442","source_url":"https://pubmed.ncbi.nlm.nih.gov/38574442/","study_design":null,"title":"Plasma oxysterols are associated with serum lipids and dementia risk in older women","title_match":false,"year":2024},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe4-decreases-spine-density-and-dendritic-complexity-in-cortical-19955384","doi":"10.1523/jneurosci.4026-09.2009","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"19955384","source_url":"https://pubmed.ncbi.nlm.nih.gov/19955384/","study_design":null,"title":"ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo","title_match":true,"year":2009},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/mechanisms-linking-apolipoprotein-e-isoforms-with-cardiovascular-and-20531185","doi":"10.1097/mol.0b013e32833af368","journal":"Current opinion in lipidology","n_participants":null,"pmid":"20531185","source_url":"https://pubmed.ncbi.nlm.nih.gov/20531185/","study_design":null,"title":"Mechanisms linking apolipoprotein E isoforms with cardiovascular and neurological diseases","title_match":false,"year":2010},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/impact-of-apolipoprotein-e-isoforms-on-sporadic-alzheimer-s-disease-37488848","doi":"10.4103/1673-5374.375316","journal":"Neural regeneration research","n_participants":null,"pmid":"37488848","source_url":"https://pubmed.ncbi.nlm.nih.gov/37488848/","study_design":null,"title":"Impact of apolipoprotein E isoforms on sporadic Alzheimer's disease: beyond the role of amyloid beta","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe4-requires-lipidation-enhancement-to-resolve-cellular-lipid-and-40301465","doi":"10.1038/s41598-025-96531-4","journal":"Scientific reports","n_participants":null,"pmid":"40301465","source_url":"https://pubmed.ncbi.nlm.nih.gov/40301465/","study_design":null,"title":"ApoE4 requires lipidation enhancement to resolve cellular lipid and protein abnormalities following NPC1 inhibition","title_match":true,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe4-impairs-macrophage-lipophagy-and-promotes-demyelination-of-40258814","doi":"10.1038/s41420-025-02454-4","journal":"Cell death discovery","n_participants":null,"pmid":"40258814","source_url":"https://pubmed.ncbi.nlm.nih.gov/40258814/","study_design":null,"title":"APOE4 impairs macrophage lipophagy and promotes demyelination of spiral ganglion neurons in mouse cochleae","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-review-of-apoe4-interference-targeting-mitophagy-molecular-pathways-35669462","doi":"10.3389/fnagi.2022.881239","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"35669462","source_url":"https://pubmed.ncbi.nlm.nih.gov/35669462/","study_design":null,"title":"A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease","title_match":true,"year":2022},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/androgens-apoe-and-alzheimer-s-disease-15028864","doi":"10.1126/sageke.2004.11.re2","journal":"Science of aging knowledge environment : SAGE KE","n_participants":null,"pmid":"15028864","source_url":"https://pubmed.ncbi.nlm.nih.gov/15028864/","study_design":null,"title":"Androgens, apoE, and Alzheimer's disease","title_match":false,"year":2004},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe4-carrying-human-astrocytes-oversupply-cholesterol-to-promote-34450034","doi":"10.1016/j.stemcr.2021.07.017","journal":"Stem cell reports","n_participants":null,"pmid":"34450034","source_url":"https://pubmed.ncbi.nlm.nih.gov/34450034/","study_design":null,"title":"APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and A\u03b2 generation","title_match":true,"year":2021},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-amyloid-beta-peptide-modulates-apolipoprotein-e-16131732","doi":"10.3233/jad-2005-7406","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"16131732","source_url":"https://pubmed.ncbi.nlm.nih.gov/16131732/","study_design":null,"title":"Alzheimer's disease amyloid-beta peptide modulates apolipoprotein E isoform specific receptor binding","title_match":false,"year":2005},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-synaptic-plasticity-and-alzheimer-s-disease-8652146","doi":"10.3109/07853899509019253","journal":"Annals of medicine","n_participants":null,"pmid":"8652146","source_url":"https://pubmed.ncbi.nlm.nih.gov/8652146/","study_design":null,"title":"Apolipoprotein E, synaptic plasticity and Alzheimer's disease","title_match":false,"year":1995},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/sex-and-apoe-isoform-dependent-effects-of-radiation-on-cognitive-17149978","doi":"10.1667/rr0642.1","journal":"Radiation research","n_participants":null,"pmid":"17149978","source_url":"https://pubmed.ncbi.nlm.nih.gov/17149978/","study_design":null,"title":"Sex- and APOE isoform-dependent effects of radiation on cognitive function","title_match":false,"year":2006},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-forms-dimers-in-human-frontal-cortex-and-hippocampus-20170526","doi":"10.1186/1471-2202-11-23","journal":"BMC neuroscience","n_participants":null,"pmid":"20170526","source_url":"https://pubmed.ncbi.nlm.nih.gov/20170526/","study_design":null,"title":"Apolipoprotein-E forms dimers in human frontal cortex and hippocampus","title_match":false,"year":2010},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apoe4-accelerates-early-seeding-of-amyloid-pathology-29216449","doi":"10.1016/j.neuron.2017.11.013","journal":"Neuron","n_participants":null,"pmid":"29216449","source_url":"https://pubmed.ncbi.nlm.nih.gov/29216449/","study_design":null,"title":"ApoE4 Accelerates Early Seeding of Amyloid Pathology","title_match":true,"year":2017},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/the-role-of-apolipoprotein-e-in-neurodegeneration-and-cardiovascular-24754513","doi":"10.1586/14789450.2014.901892","journal":"Expert review of proteomics","n_participants":null,"pmid":"24754513","source_url":"https://pubmed.ncbi.nlm.nih.gov/24754513/","study_design":null,"title":"The role of apolipoprotein E in neurodegeneration and cardiovascular disease","title_match":false,"year":2014},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/human-apolipoprotein-e-4-expression-impairs-cerebral-vascularization-25335802","doi":"10.1038/jcbfm.2014.172","journal":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","n_participants":null,"pmid":"25335802","source_url":"https://pubmed.ncbi.nlm.nih.gov/25335802/","study_design":null,"title":"Human apolipoprotein E \u025b4 expression impairs cerebral vascularization and blood-brain barrier function in mice","title_match":false,"year":2015},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-isoforms-in-alzheimer-s-disease-pathology-and-10936880","doi":"10.1002/1097-0029(20000815)50:4<278::aid-jemt5>3.0.co;2-t","journal":"Microscopy research and technique","n_participants":null,"pmid":"10936880","source_url":"https://pubmed.ncbi.nlm.nih.gov/10936880/","study_design":null,"title":"Apolipoprotein E isoforms in Alzheimer's disease pathology and etiology","title_match":false,"year":2000},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-as-vascular-risk-factor-in-neurodegenerative-dementia-15375590","doi":null,"journal":"International journal of molecular medicine","n_participants":null,"pmid":"15375590","source_url":"https://pubmed.ncbi.nlm.nih.gov/15375590/","study_design":null,"title":"Apolipoprotein E as vascular risk factor in neurodegenerative dementia","title_match":false,"year":2004},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-sets-the-stage-response-to-injury-triggers-23217737","doi":"10.1016/j.neuron.2012.11.020","journal":"Neuron","n_participants":null,"pmid":"23217737","source_url":"https://pubmed.ncbi.nlm.nih.gov/23217737/","study_design":null,"title":"Apolipoprotein e sets the stage: response to injury triggers neuropathology","title_match":false,"year":2012},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/relationships-between-apoe-type-2-diabetes-and-cardiovascular-disease-39364911","doi":"10.1093/gerona/glae246","journal":"The journals of gerontology. Series A, Biological sciences and medical sciences","n_participants":564,"pmid":"39364911","source_url":"https://pubmed.ncbi.nlm.nih.gov/39364911/","study_design":null,"title":"Relationships Between APOE, Type 2 Diabetes, and Cardiovascular Disease in Postmenopausal Women","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/crosslinking-of-apolipoprotein-e-by-products-of-lipid-peroxidation-8786379","doi":"10.1097/00005072-199602000-00009","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"8786379","source_url":"https://pubmed.ncbi.nlm.nih.gov/8786379/","study_design":null,"title":"Crosslinking of apolipoprotein E by products of lipid peroxidation","title_match":false,"year":1996},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apoe-genotype-alters-glial-activation-and-loss-of-synaptic-markers-in-22228589","doi":"10.1002/glia.22289","journal":"Glia","n_participants":null,"pmid":"22228589","source_url":"https://pubmed.ncbi.nlm.nih.gov/22228589/","study_design":null,"title":"APOE genotype alters glial activation and loss of synaptic markers in mice","title_match":false,"year":2012},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/does-apolipoprotein-e-genotype-modify-the-clinical-expression-of-als-20880000","doi":"10.1111/j.1468-1331.2010.03225.x","journal":"European journal of neurology","n_participants":null,"pmid":"20880000","source_url":"https://pubmed.ncbi.nlm.nih.gov/20880000/","study_design":null,"title":"Does apolipoprotein E genotype modify the clinical expression of ALS?","title_match":false,"year":2011},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-genotype-alzheimer-s-pathologies-and-related-gene-7770005","doi":"10.1016/0169-328x(94)00233-5","journal":"Brain research. Molecular brain research","n_participants":null,"pmid":"7770005","source_url":"https://pubmed.ncbi.nlm.nih.gov/7770005/","study_design":null,"title":"Apolipoprotein E genotype, Alzheimer's pathologies and related gene expression in the aged population","title_match":false,"year":1995},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe-effect-on-alzheimer-s-disease-biomarkers-in-older-adults-with-25960448","doi":"10.1016/j.jalz.2015.03.003","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"25960448","source_url":"https://pubmed.ncbi.nlm.nih.gov/25960448/","study_design":null,"title":"APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern","title_match":false,"year":2015},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe4-related-differences-in-cortical-thickness-are-modulated-by-sex-39196521","doi":"10.1007/s11682-024-00911-9","journal":"Brain imaging and behavior","n_participants":null,"pmid":"39196521","source_url":"https://pubmed.ncbi.nlm.nih.gov/39196521/","study_design":null,"title":"APOE4-related differences in cortical thickness are modulated by sex in middle age","title_match":true,"year":2024},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-expression-and-purification-20967588","doi":"10.1007/978-1-60761-744-0_10","journal":"Methods in molecular biology (Clifton, N.J.)","n_participants":null,"pmid":"20967588","source_url":"https://pubmed.ncbi.nlm.nih.gov/20967588/","study_design":null,"title":"Apolipoprotein E expression and purification","title_match":false,"year":2011},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/brain-apolipoprotein-e-levels-in-mice-challenged-by-a-western-diet-38058491","doi":"10.1016/j.nbas.2023.100102","journal":"Aging brain","n_participants":null,"pmid":"38058491","source_url":"https://pubmed.ncbi.nlm.nih.gov/38058491/","study_design":null,"title":"Brain apolipoprotein E levels in mice challenged by a Western diet increase in an allele-dependent manner","title_match":false,"year":2023},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/human-apolipoprotein-e-isoform-specific-differences-in-neuronal-10582625","doi":"10.1046/j.1471-4159.1999.0732613.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"10582625","source_url":"https://pubmed.ncbi.nlm.nih.gov/10582625/","study_design":null,"title":"Human apolipoprotein E isoform-specific differences in neuronal sprouting in organotypic hippocampal culture","title_match":false,"year":1999},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/a-dual-role-for-apolipoprotein-e-in-neuroinflammation-anti-and-pro-15181248","doi":"10.1385/jmn:23:3:205","journal":"Journal of molecular neuroscience : MN","n_participants":null,"pmid":"15181248","source_url":"https://pubmed.ncbi.nlm.nih.gov/15181248/","study_design":null,"title":"A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity","title_match":false,"year":2004},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/association-of-human-rat-and-rabbit-apolipoprotein-e-with-beta-amyloid-9211985","doi":null,"journal":"Journal of neuroscience research","n_participants":null,"pmid":"9211985","source_url":"https://pubmed.ncbi.nlm.nih.gov/9211985/","study_design":null,"title":"Association of human, rat, and rabbit apolipoprotein E with beta-amyloid","title_match":false,"year":1997},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/opposing-effects-of-apoe2-and-apoe4-on-glycolytic-metabolism-in-36766752","doi":"10.3390/cells12030410","journal":"Cells","n_participants":null,"pmid":"36766752","source_url":"https://pubmed.ncbi.nlm.nih.gov/36766752/","study_design":null,"title":"Opposing Effects of ApoE2 and ApoE4 on Glycolytic Metabolism in Neuronal Aging Supports a Warburg Neuroprotective Cascade against Alzheimer's Disease","title_match":true,"year":2023},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/functional-characterization-of-apolipoprotein-e-isoforms-10419818","doi":"10.1006/prep.1999.1069","journal":"Protein expression and purification","n_participants":null,"pmid":"10419818","source_url":"https://pubmed.ncbi.nlm.nih.gov/10419818/","study_design":null,"title":"Functional characterization of apolipoprotein E isoforms overexpressed in Escherichia coli","title_match":false,"year":1999},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/a-biophysical-approach-to-the-identification-of-novel-apoe-chemical-30700058","doi":"10.3390/biom9020048","journal":"Biomolecules","n_participants":null,"pmid":"30700058","source_url":"https://pubmed.ncbi.nlm.nih.gov/30700058/","study_design":null,"title":"A Biophysical Approach to the Identification of Novel ApoE Chemical Probes","title_match":false,"year":2019},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/retinal-dysfunction-in-apoe4-knock-in-mouse-model-of-alzheimer-s-39749840","doi":"10.1002/alz.14433","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39749840","source_url":"https://pubmed.ncbi.nlm.nih.gov/39749840/","study_design":null,"title":"Retinal dysfunction in APOE4 knock-in mouse model of Alzheimer's disease","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/from-degenerative-disease-to-malignant-tumors-insight-to-the-function-36516696","doi":"10.1016/j.biopha.2022.114127","journal":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","n_participants":null,"pmid":"36516696","source_url":"https://pubmed.ncbi.nlm.nih.gov/36516696/","study_design":null,"title":"From degenerative disease to malignant tumors: Insight to the function of ApoE","title_match":false,"year":2023},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-amyloid-beta-and-neuroinflammation-in-alzheimer-s-24652457","doi":"10.1007/s12264-013-1422-z","journal":"Neuroscience bulletin","n_participants":null,"pmid":"24652457","source_url":"https://pubmed.ncbi.nlm.nih.gov/24652457/","study_design":null,"title":"Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/multiomics-integrative-analysis-identifies-apoe-allele-specific-blood-33846280","doi":"10.18632/aging.202950","journal":"Aging","n_participants":null,"pmid":"33846280","source_url":"https://pubmed.ncbi.nlm.nih.gov/33846280/","study_design":null,"title":"Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer's disease etiopathogenesis","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-influences-of-apoe-isoforms-on-endothelial-adherens-junctions-and-39276310","doi":"10.1007/s10456-024-09946-4","journal":"Angiogenesis","n_participants":null,"pmid":"39276310","source_url":"https://pubmed.ncbi.nlm.nih.gov/39276310/","study_design":null,"title":"The influences of ApoE isoforms on endothelial adherens junctions and actin cytoskeleton responding to mCRP","title_match":false,"year":2024},{"alzhub_score":10,"alzhub_url":"https://alzhub.org/study/integrative-genomics-identifies-apoe-4-effectors-in-alzheimer-s-23883936","doi":"10.1038/nature12415","journal":"Nature","n_participants":null,"pmid":"23883936","source_url":"https://pubmed.ncbi.nlm.nih.gov/23883936/","study_design":null,"title":"Integrative genomics identifies APOE \u03b54 effectors in Alzheimer's disease","title_match":true,"year":2013},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/polygenic-risk-score-analysis-of-alzheimer-s-disease-in-cases-without-30569081","doi":"10.14283/jpad.2018.46","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"30569081","source_url":"https://pubmed.ncbi.nlm.nih.gov/30569081/","study_design":null,"title":"Polygenic Risk Score Analysis of Alzheimer's Disease in Cases without APOE4 or APOE2 Alleles","title_match":true,"year":2019},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apoe-differentially-moderates-cerebrospinal-fluid-and-plasma-36780762","doi":"10.1016/j.neurobiolaging.2022.10.016","journal":"Neurobiology of aging","n_participants":727,"pmid":"36780762","source_url":"https://pubmed.ncbi.nlm.nih.gov/36780762/","study_design":null,"title":"APOE differentially moderates cerebrospinal fluid and plasma phosphorylated tau181 associations with multi-domain cognition","title_match":false,"year":2023},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/impaired-fasting-glucose-is-associated-with-increased-regional-27318141","doi":"10.1016/j.neurobiolaging.2016.04.017","journal":"Neurobiology of aging","n_participants":73,"pmid":"27318141","source_url":"https://pubmed.ncbi.nlm.nih.gov/27318141/","study_design":null,"title":"Impaired fasting glucose is associated with increased regional cerebral amyloid","title_match":false,"year":2016},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/tacrine-and-rate-of-progression-in-alzheimer-s-disease-relation-to-11475012","doi":"10.1007/s007020170066","journal":"Journal of neural transmission (Vienna, Austria : 1996)","n_participants":null,"pmid":"11475012","source_url":"https://pubmed.ncbi.nlm.nih.gov/11475012/","study_design":null,"title":"Tacrine and rate of progression in Alzheimer's disease--relation to ApoE allele genotype","title_match":false,"year":2001},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-multi-hit-hypothesis-for-an-apoe4-dependent-pathophysiological-state-35510513","doi":"10.1111/ejn.15685","journal":"The European journal of neuroscience","n_participants":null,"pmid":"35510513","source_url":"https://pubmed.ncbi.nlm.nih.gov/35510513/","study_design":null,"title":"A multi-hit hypothesis for an APOE4-dependent pathophysiological state","title_match":true,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/polygenic-effects-on-the-risk-of-alzheimer-s-disease-in-the-japanese-38414085","doi":"10.1186/s13195-024-01414-x","journal":"Alzheimer's research & therapy","n_participants":565,"pmid":"38414085","source_url":"https://pubmed.ncbi.nlm.nih.gov/38414085/","study_design":null,"title":"Polygenic effects on the risk of Alzheimer's disease in the Japanese population","title_match":false,"year":2024},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/polygenic-score-modifies-risk-for-alzheimer-s-disease-in-apoe-4-34386572","doi":"10.1002/dad2.12226","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":213,"pmid":"34386572","source_url":"https://pubmed.ncbi.nlm.nih.gov/34386572/","study_design":null,"title":"Polygenic score modifies risk for Alzheimer's disease in APOE \u03b54 homozygotes at phenotypic extremes","title_match":true,"year":2021},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/genome-wide-association-studies-identify-novel-loci-in-rapidly-38184787","doi":"10.1002/alz.13655","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38184787","source_url":"https://pubmed.ncbi.nlm.nih.gov/38184787/","study_design":null,"title":"Genome-wide association studies identify novel loci in rapidly progressive Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/gwas-linked-loci-and-neuroimaging-measures-in-alzheimer-s-disease-26732597","doi":"10.1007/s12035-015-9669-1","journal":"Molecular neurobiology","n_participants":null,"pmid":"26732597","source_url":"https://pubmed.ncbi.nlm.nih.gov/26732597/","study_design":"meta-analysis","title":"GWAS-Linked Loci and Neuroimaging Measures in Alzheimer's Disease","title_match":false,"year":2017},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/genetic-drivers-of-progression-in-alzheimer-s-disease-are-distinct-41332834","doi":"10.1101/2025.11.17.25340247","journal":"medRxiv : the preprint server for health sciences","n_participants":222,"pmid":"41332834","source_url":"https://pubmed.ncbi.nlm.nih.gov/41332834/","study_design":"meta-analysis","title":"Genetic drivers of progression in Alzheimer's disease are distinct from disease risk","title_match":false,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/gwas-links-apoe-to-neuropsychiatric-symptoms-in-mild-cognitive-40495575","doi":"10.1002/alz.70329","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":12800,"pmid":"40495575","source_url":"https://pubmed.ncbi.nlm.nih.gov/40495575/","study_design":null,"title":"GWAS links APOE to neuropsychiatric symptoms in mild cognitive impairment and dementia","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/genetic-effects-and-gene-by-education-interactions-on-episodic-memory-30449520","doi":"10.1016/j.socscimed.2018.11.019","journal":"Social science & medicine (1982)","n_participants":null,"pmid":"30449520","source_url":"https://pubmed.ncbi.nlm.nih.gov/30449520/","study_design":null,"title":"Genetic effects and gene-by-education interactions on episodic memory performance and decline in an aging population","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-genetic-architecture-of-alzheimer-disease-risk-in-the-ohio-and-35599847","doi":"10.1016/j.xhgg.2022.100114","journal":"HGG advances","n_participants":null,"pmid":"35599847","source_url":"https://pubmed.ncbi.nlm.nih.gov/35599847/","study_design":null,"title":"The genetic architecture of Alzheimer disease risk in the Ohio and Indiana Amish","title_match":false,"year":2022},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-genetic-risk-variants-beyond-apoe-4-predict-28983503","doi":"10.1016/j.dadm.2017.07.002","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"28983503","source_url":"https://pubmed.ncbi.nlm.nih.gov/28983503/","study_design":"case-control study","title":"Alzheimer's disease genetic risk variants beyond APOE \u03b54 predict mortality","title_match":true,"year":2017},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/the-genetic-variability-of-apoe-in-different-human-populations-and-30884759","doi":"10.3390/genes10030222","journal":"Genes","n_participants":null,"pmid":"30884759","source_url":"https://pubmed.ncbi.nlm.nih.gov/30884759/","study_design":null,"title":"The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity","title_match":false,"year":2019},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/cross-ancestry-genome-wide-association-study-identifies-implications-40175353","doi":"10.1038/s41467-025-57751-4","journal":"Nature communications","n_participants":null,"pmid":"40175353","source_url":"https://pubmed.ncbi.nlm.nih.gov/40175353/","study_design":"meta-analysis","title":"Cross-ancestry genome-wide association study identifies implications of SORL1 in cerebral beta-amyloid deposition","title_match":false,"year":2025},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/genetics-of-alzheimer-s-disease-the-importance-of-polygenic-and-28825204","doi":"10.1007/s11910-017-0787-1","journal":"Current neurology and neuroscience reports","n_participants":null,"pmid":"28825204","source_url":"https://pubmed.ncbi.nlm.nih.gov/28825204/","study_design":null,"title":"Genetics of Alzheimer's Disease: the Importance of Polygenic and Epistatic Components","title_match":false,"year":2017},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/genetic-risk-scores-enhance-the-diagnostic-value-of-plasma-biomarkers-37279785","doi":"10.1093/brain/awad196","journal":"Brain : a journal of neurology","n_participants":962,"pmid":"37279785","source_url":"https://pubmed.ncbi.nlm.nih.gov/37279785/","study_design":null,"title":"Genetic risk scores enhance the diagnostic value of plasma biomarkers of brain amyloidosis","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/novel-alzheimer-s-disease-risk-variants-identified-based-on-whole-34011927","doi":"10.1038/s41398-021-01412-9","journal":"Translational psychiatry","n_participants":null,"pmid":"34011927","source_url":"https://pubmed.ncbi.nlm.nih.gov/34011927/","study_design":null,"title":"Novel Alzheimer's disease risk variants identified based on whole-genome sequencing of APOE \u03b54 carriers","title_match":true,"year":2021},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/interplay-between-socioeconomic-markers-and-polygenic-predisposition-32187654","doi":"10.1111/jgs.16406","journal":"Journal of the American Geriatrics Society","n_participants":7039,"pmid":"32187654","source_url":"https://pubmed.ncbi.nlm.nih.gov/32187654/","study_design":"prospective cohort","title":"Interplay between Socioeconomic Markers and Polygenic Predisposition on Timing of Dementia Diagnosis","title_match":false,"year":2020},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/integrating-neuroinflammation-biomarkers-into-the-atn-x-framework-40801241","doi":"10.1002/alz.70472","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40801241","source_url":"https://pubmed.ncbi.nlm.nih.gov/40801241/","study_design":null,"title":"Integrating neuroinflammation biomarkers into the ATN(X) framework: Advances in Alzheimer's pathogenesis, diagnosis, and insights from non-human primate models","title_match":false,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/trem2-coding-variants-in-slovak-alzheimer-s-disease-patients-35864757","doi":"10.31083/j.jin2104105","journal":"Journal of integrative neuroscience","n_participants":null,"pmid":"35864757","source_url":"https://pubmed.ncbi.nlm.nih.gov/35864757/","study_design":null,"title":"TREM2 coding variants in Slovak Alzheimer's disease patients","title_match":false,"year":2022},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/peripheral-trem2-mrna-levels-in-early-and-late-onset-alzheimer-32681391","doi":"10.1007/s11033-020-05661-7","journal":"Molecular biology reports","n_participants":null,"pmid":"32681391","source_url":"https://pubmed.ncbi.nlm.nih.gov/32681391/","study_design":null,"title":"Peripheral TREM2 mRNA levels in early and late-onset Alzheimer disease's patients","title_match":false,"year":2020},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/neuroimaging-biomarkers-and-csf-strem2-levels-in-alzheimer-s-disease-38961148","doi":"10.1038/s41598-024-66211-w","journal":"Scientific reports","n_participants":1001,"pmid":"38961148","source_url":"https://pubmed.ncbi.nlm.nih.gov/38961148/","study_design":"longitudinal study","title":"Neuroimaging biomarkers and CSF sTREM2 levels in Alzheimer's disease: a longitudinal study","title_match":false,"year":2024},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/different-mechanisms-of-apolipoprotein-e-isoform-dependent-modulation-25593125","doi":"10.1096/fj.14-262683","journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","n_participants":null,"pmid":"25593125","source_url":"https://pubmed.ncbi.nlm.nih.gov/25593125/","study_design":null,"title":"Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia","title_match":false,"year":2015},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe4-and-risk-of-alzheimer-s-disease-time-to-move-forward-37274212","doi":"10.3389/fnins.2023.1195724","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"37274212","source_url":"https://pubmed.ncbi.nlm.nih.gov/37274212/","study_design":null,"title":"APOE\u03b54 and risk of Alzheimer's disease - time to move forward","title_match":true,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/the-emerging-roles-and-therapeutic-potential-of-soluble-trem2-in-32038221","doi":"10.3389/fnagi.2019.00328","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"32038221","source_url":"https://pubmed.ncbi.nlm.nih.gov/32038221/","study_design":null,"title":"The Emerging Roles and Therapeutic Potential of Soluble TREM2 in Alzheimer's Disease","title_match":false,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/genetics-of-early-onset-alzheimer-dementia-12847300","doi":"10.1100/tsw.2003.39","journal":"TheScientificWorldJournal","n_participants":null,"pmid":"12847300","source_url":"https://pubmed.ncbi.nlm.nih.gov/12847300/","study_design":null,"title":"Genetics of early-onset Alzheimer dementia","title_match":false,"year":2003},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/variability-in-the-type-and-layer-distribution-of-cortical-a-34319632","doi":"10.1111/bpa.13009","journal":"Brain pathology (Zurich, Switzerland)","n_participants":null,"pmid":"34319632","source_url":"https://pubmed.ncbi.nlm.nih.gov/34319632/","study_design":null,"title":"Variability in the type and layer distribution of cortical A\u03b2 pathology in familial Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/single-nucleus-multiregion-transcriptomic-analysis-of-brain-37264161","doi":"10.1038/s41593-023-01334-3","journal":"Nature neuroscience","n_participants":220,"pmid":"37264161","source_url":"https://pubmed.ncbi.nlm.nih.gov/37264161/","study_design":null,"title":"Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/tau-pet-positivity-in-individuals-with-and-without-cognitive-40670684","doi":"10.1038/s41593-025-02000-6","journal":"Nature neuroscience","n_participants":12048,"pmid":"40670684","source_url":"https://pubmed.ncbi.nlm.nih.gov/40670684/","study_design":null,"title":"Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-\u03b2 status, APOE genotype and sex","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/association-of-the-top-20-alzheimer-s-disease-risk-genes-with-18f-35592828","doi":"10.1002/dad2.12308","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"35592828","source_url":"https://pubmed.ncbi.nlm.nih.gov/35592828/","study_design":null,"title":"Association of the top 20 Alzheimer's disease risk genes with [18F]flortaucipir PET","title_match":false,"year":2022},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/predicting-amyloid-pet-positivity-using-plasma-p-tau181-and-other-38026758","doi":"10.1002/dad2.12502","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"38026758","source_url":"https://pubmed.ncbi.nlm.nih.gov/38026758/","study_design":"cohort study","title":"Predicting amyloid PET positivity using plasma p-tau181 and other blood-based biomarkers","title_match":false,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/prognostic-value-of-amyloid-pet-scan-in-normal-pressure-hydrocephalus-29128930","doi":"10.1007/s00415-017-8650-5","journal":"Journal of neurology","n_participants":31,"pmid":"29128930","source_url":"https://pubmed.ncbi.nlm.nih.gov/29128930/","study_design":null,"title":"Prognostic value of amyloid PET scan in normal pressure hydrocephalus","title_match":false,"year":2018},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/added-value-of-amyloid-pet-in-individualized-risk-predictions-for-mci-31388557","doi":"10.1016/j.dadm.2019.04.011","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":411,"pmid":"31388557","source_url":"https://pubmed.ncbi.nlm.nih.gov/31388557/","study_design":null,"title":"Added value of amyloid PET in individualized risk predictions for MCI patients","title_match":false,"year":2019},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/apoe4-potentiates-the-relationship-between-amyloid-and-tau-pathologies-32161362","doi":"10.1038/s41380-020-0688-6","journal":"Molecular psychiatry","n_participants":211,"pmid":"32161362","source_url":"https://pubmed.ncbi.nlm.nih.gov/32161362/","study_design":null,"title":"APOE\u03b54 potentiates the relationship between amyloid-\u03b2 and tau pathologies","title_match":true,"year":2021},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/brain-amyloid-burden-and-resting-state-functional-connectivity-in-33123070","doi":"10.3389/fneur.2020.529930","journal":"Frontiers in neurology","n_participants":null,"pmid":"33123070","source_url":"https://pubmed.ncbi.nlm.nih.gov/33123070/","study_design":null,"title":"Brain Amyloid Burden and Resting-State Functional Connectivity in Late Middle-Aged Hispanics","title_match":false,"year":2020},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/differential-default-mode-network-trajectories-in-asymptomatic-31113760","doi":"10.1016/j.jalz.2019.03.006","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"31113760","source_url":"https://pubmed.ncbi.nlm.nih.gov/31113760/","study_design":"cross-sectional","title":"Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/sex-differences-in-interacting-genetic-and-functional-connectivity-38598069","doi":"10.1007/s11357-024-01151-x","journal":"GeroScience","n_participants":30,"pmid":"38598069","source_url":"https://pubmed.ncbi.nlm.nih.gov/38598069/","study_design":null,"title":"Sex differences in interacting genetic and functional connectivity biomarkers in Alzheimer's disease","title_match":false,"year":2024},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/apoe-4-and-resting-state-functional-connectivity-in-racially-32999914","doi":"10.1002/dad2.12094","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":166,"pmid":"32999914","source_url":"https://pubmed.ncbi.nlm.nih.gov/32999914/","study_design":null,"title":"APOE \u03b54 and resting-state functional connectivity in racially/ethnically diverse older adults","title_match":true,"year":2020},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/retinal-microvasculature-and-incident-dementia-over-10-years-the-37915467","doi":"10.1002/dad2.12480","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":584,"pmid":"37915467","source_url":"https://pubmed.ncbi.nlm.nih.gov/37915467/","study_design":"longitudinal study","title":"Retinal microvasculature and incident dementia over 10 years: The Three-City-Alienor cohort","title_match":false,"year":2023},{"alzhub_score":68,"alzhub_url":"https://alzhub.org/study/longitudinal-multimodal-retinal-imaging-in-cognitively-normal-42937433","doi":"10.1167/tvst.15.10.45","journal":"Translational vision science & technology","n_participants":58,"pmid":"42937433","source_url":"https://pubmed.ncbi.nlm.nih.gov/42937433/","study_design":"longitudinal study","title":"Longitudinal Multimodal Retinal Imaging in Cognitively Normal Apolipoprotein E4 Carriers and Noncarriers","title_match":true,"year":2026},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/assessing-outer-retinal-and-choroidal-changes-in-scd-potential-for-41315191","doi":"10.1038/s41398-025-03781-x","journal":"Translational psychiatry","n_participants":57,"pmid":"41315191","source_url":"https://pubmed.ncbi.nlm.nih.gov/41315191/","study_design":null,"title":"Assessing outer retinal and choroidal changes in scd: potential for high-risk screening using SS-OCTA","title_match":false,"year":2025},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/retinal-imaging-demonstrates-reduced-capillary-density-in-clinically-34013017","doi":"10.1002/dad2.12181","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"34013017","source_url":"https://pubmed.ncbi.nlm.nih.gov/34013017/","study_design":null,"title":"Retinal imaging demonstrates reduced capillary density in clinically unimpaired APOE \u03b54 gene carriers","title_match":true,"year":2021},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/lecanemab-appropriate-use-recommendations-for-clinical-practice-in-41390238","doi":"10.1136/jnnp-2025-336597","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"41390238","source_url":"https://pubmed.ncbi.nlm.nih.gov/41390238/","study_design":null,"title":"Lecanemab appropriate use recommendations for clinical practice in the UK","title_match":false,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/lecanemab-leqembi-is-not-the-right-drug-for-patients-with-alzheimer-s-37676096","doi":"10.17219/acem/171379","journal":"Advances in clinical and experimental medicine : official organ Wroclaw Medical University","n_participants":null,"pmid":"37676096","source_url":"https://pubmed.ncbi.nlm.nih.gov/37676096/","study_design":null,"title":"Lecanemab (Leqembi) is not the right drug for patients with Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/anti-amyloid-agents-a-self-fulfilling-prophecy-40393205","doi":"10.1016/j.jocn.2025.111338","journal":"Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia","n_participants":null,"pmid":"40393205","source_url":"https://pubmed.ncbi.nlm.nih.gov/40393205/","study_design":null,"title":"Anti-Amyloid Agents: A Self-Fulfilling prophecy","title_match":false,"year":2025},{"alzhub_score":83,"alzhub_url":"https://alzhub.org/study/lecanemab-for-treatment-of-individuals-with-early-alzheimer-s-disease-41689888","doi":"10.1016/j.tjpad.2026.100507","journal":"The journal of prevention of Alzheimer's disease","n_participants":1795,"pmid":"41689888","source_url":"https://pubmed.ncbi.nlm.nih.gov/41689888/","study_design":"clinical trial","title":"Lecanemab for treatment of individuals with early Alzheimer's Disease (AD) who are apolipoprotein E \u03b54 (ApoE \u03b54) non-carriers or heterozygotes","title_match":true,"year":2026},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/real-world-application-of-lecanemab-in-early-stage-alzheimer-s-41250246","doi":"10.1186/s13195-025-01886-5","journal":"Alzheimer's research & therapy","n_participants":14,"pmid":"41250246","source_url":"https://pubmed.ncbi.nlm.nih.gov/41250246/","study_design":"cohort study","title":"Real-world application of lecanemab in early-stage alzheimer's disease: a single-center prospective cohort analysis","title_match":false,"year":2025},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/amyloid-related-imaging-abnormalities-in-japanese-patients-with-41936348","doi":"10.1016/j.tjpad.2026.100562","journal":"The journal of prevention of Alzheimer's disease","n_participants":120,"pmid":"41936348","source_url":"https://pubmed.ncbi.nlm.nih.gov/41936348/","study_design":"longitudinal study","title":"Amyloid-related imaging abnormalities in Japanese patients with Alzheimer's disease treated with Lecanemab: A real-world study","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/symptomatic-amyloid-related-imaging-abnormalities-in-an-apoe-4-4-33072846","doi":"10.1002/dad2.12101","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"33072846","source_url":"https://pubmed.ncbi.nlm.nih.gov/33072846/","study_design":null,"title":"Symptomatic amyloid-related imaging abnormalities in an APOE \u03b54/\u03b54 patient treated with aducanumab","title_match":true,"year":2020},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/antibody-therapy-in-alzheimer-s-disease-42714614","doi":"10.1007/s00391-026-02640-8","journal":"Zeitschrift fur Gerontologie und Geriatrie","n_participants":null,"pmid":"42714614","source_url":"https://pubmed.ncbi.nlm.nih.gov/42714614/","study_design":null,"title":"[Antibody therapy in Alzheimer's disease]","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/from-bench-to-bedside-cutting-edge-and-emerging-therapies-for-40993929","doi":"10.2174/0118715249388723250910140541","journal":"Central nervous system agents in medicinal chemistry","n_participants":null,"pmid":"40993929","source_url":"https://pubmed.ncbi.nlm.nih.gov/40993929/","study_design":null,"title":"From Bench to Bedside: Cutting-Edge and Emerging Therapies for Alzheimer's Disease","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/amyloid-related-imaging-abnormality-aria-beyond-the-apoe-4-allele-40951730","doi":"10.1002/cdt3.70006","journal":"Chronic diseases and translational medicine","n_participants":null,"pmid":"40951730","source_url":"https://pubmed.ncbi.nlm.nih.gov/40951730/","study_design":null,"title":"Amyloid-Related Imaging Abnormality (ARIA) Beyond the APOE-\u03b54 Allele","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/guidelines-for-pharmacotherapy-in-alzheimer-s-disease-a-primer-on-fda-38059250","doi":"10.25259/jnrp_356_2023","journal":"Journal of neurosciences in rural practice","n_participants":null,"pmid":"38059250","source_url":"https://pubmed.ncbi.nlm.nih.gov/38059250/","study_design":null,"title":"Guidelines for pharmacotherapy in Alzheimer's disease - A primer on FDA-approved drugs","title_match":false,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/deciphering-the-roles-of-metformin-in-alzheimer-s-disease-a-snapshot-35153733","doi":"10.3389/fphar.2021.728315","journal":"Frontiers in pharmacology","n_participants":null,"pmid":"35153733","source_url":"https://pubmed.ncbi.nlm.nih.gov/35153733/","study_design":null,"title":"Deciphering the Roles of Metformin in Alzheimer's Disease: A Snapshot","title_match":false,"year":2021},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/clinical-effects-of-tramiprosate-in-apoe4-4-homozygous-patients-with-29182706","doi":"10.14283/jpad.2017.26","journal":"The journal of prevention of Alzheimer's disease","n_participants":147,"pmid":"29182706","source_url":"https://pubmed.ncbi.nlm.nih.gov/29182706/","study_design":"clinical trial","title":"Clinical Effects of Tramiprosate in APOE4/4 Homozygous Patients with Mild Alzheimer's Disease Suggest Disease Modification Potential","title_match":true,"year":2017},{"alzhub_score":80,"alzhub_url":"https://alzhub.org/study/a-phase-ii-single-center-randomized-double-blind-placebo-controlled-33719017","doi":"10.1007/s40266-021-00845-7","journal":"Drugs & aging","n_participants":null,"pmid":"33719017","source_url":"https://pubmed.ncbi.nlm.nih.gov/33719017/","study_design":null,"title":"A Phase II, Single-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Therapeutic Efficacy of Intranasal Glulisine in Amnestic Mild Cognitive Impairment and Probable Mild Alzheimer's Disease","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/sulfopropanoic-acid-derivatives-for-treating-neurodegenerative-40828109","doi":"10.1080/20468954.2024.2363657","journal":"Pharmaceutical patent analyst","n_participants":null,"pmid":"40828109","source_url":"https://pubmed.ncbi.nlm.nih.gov/40828109/","study_design":null,"title":"Sulfopropanoic acid derivatives for treating neurodegenerative disorders: a patent spotlight","title_match":false,"year":2024},{"alzhub_score":73,"alzhub_url":"https://alzhub.org/study/effects-of-anserine-carnosine-supplementation-on-mild-cognitive-31319510","doi":"10.3390/nu11071626","journal":"Nutrients","n_participants":null,"pmid":"31319510","source_url":"https://pubmed.ncbi.nlm.nih.gov/31319510/","study_design":null,"title":"Effects of Anserine/Carnosine Supplementation on Mild Cognitive Impairment with APOE4","title_match":true,"year":2019},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/risk-reduction-and-precision-prevention-across-the-alzheimer-s-41145344","doi":"10.1016/j.tjpad.2025.100367","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"41145344","source_url":"https://pubmed.ncbi.nlm.nih.gov/41145344/","study_design":null,"title":"Risk reduction and precision prevention across the Alzheimer's disease continuum: a systematic review of clinical trials combining multidomain lifestyle interventions and pharmacological or nutraceutical approaches","title_match":false,"year":2025},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/polygenicity-and-apoe-4-shape-response-to-intervention-in-mild-41388319","doi":"10.1186/s13195-025-01907-3","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"41388319","source_url":"https://pubmed.ncbi.nlm.nih.gov/41388319/","study_design":null,"title":"Polygenicity and APOE \u03b54 shape response to intervention in mild cognitive impairment","title_match":true,"year":2025},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/aerobic-exercise-improves-hippocampal-blood-flow-for-hypertensive-33509035","doi":"10.1177/0271678x21990342","journal":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","n_participants":44,"pmid":"33509035","source_url":"https://pubmed.ncbi.nlm.nih.gov/33509035/","study_design":null,"title":"Aerobic exercise improves hippocampal blood flow for hypertensive Apolipoprotein E4 carriers","title_match":true,"year":2021},{"alzhub_score":84,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-genetic-risk-score-and-neuroimaging-in-the-finger-38647197","doi":"10.1002/alz.13843","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":126,"pmid":"38647197","source_url":"https://pubmed.ncbi.nlm.nih.gov/38647197/","study_design":null,"title":"Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial","title_match":false,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/sleep-and-neurodegeneration-42544975","doi":"10.1212/cont.0000000000001734","journal":"Continuum (Minneapolis, Minn.)","n_participants":null,"pmid":"42544975","source_url":"https://pubmed.ncbi.nlm.nih.gov/42544975/","study_design":null,"title":"Sleep and Neurodegeneration","title_match":false,"year":2026},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/obstructive-sleep-apnea-and-cognitive-decline-a-review-of-potential-34071739","doi":"10.3390/brainsci11060706","journal":"Brain sciences","n_participants":null,"pmid":"34071739","source_url":"https://pubmed.ncbi.nlm.nih.gov/34071739/","study_design":"cohort study","title":"Obstructive Sleep Apnea and Cognitive Decline: A Review of Potential Vulnerability and Protective Factors","title_match":false,"year":2021},{"alzhub_score":70,"alzhub_url":"https://alzhub.org/study/hearing-impairment-and-cognitive-decline-in-older-community-dwelling-30753308","doi":"10.1093/gerona/glz035","journal":"The journals of gerontology. Series A, Biological sciences and medical sciences","n_participants":1164,"pmid":"30753308","source_url":"https://pubmed.ncbi.nlm.nih.gov/30753308/","study_design":"longitudinal study","title":"Hearing Impairment and Cognitive Decline in Older, Community-Dwelling Adults","title_match":false,"year":2020},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-allele-and-hearing-thresholds-in-older-adults-24906966","doi":"10.1177/1533317514537549","journal":"American journal of Alzheimer's disease and other dementias","n_participants":1833,"pmid":"24906966","source_url":"https://pubmed.ncbi.nlm.nih.gov/24906966/","study_design":"cross-sectional","title":"Apolipoprotein E Allele and Hearing Thresholds in Older Adults","title_match":false,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/role-of-diet-and-exercise-in-aging-alzheimer-s-disease-and-other-37832608","doi":"10.1016/j.arr.2023.102091","journal":"Ageing research reviews","n_participants":null,"pmid":"37832608","source_url":"https://pubmed.ncbi.nlm.nih.gov/37832608/","study_design":null,"title":"Role of diet and exercise in aging, Alzheimer's disease, and other chronic diseases","title_match":false,"year":2023},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/cardiometabolic-and-vascular-disease-factors-and-mild-cognitive-35081540","doi":"10.1159/000521547","journal":"Gerontology","n_participants":null,"pmid":"35081540","source_url":"https://pubmed.ncbi.nlm.nih.gov/35081540/","study_design":"longitudinal study","title":"Cardiometabolic and Vascular Disease Factors and Mild Cognitive Impairment and Dementia","title_match":false,"year":2022},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/multisystem-failure-tipping-points-and-risk-of-alzheimer-s-disease-40346724","doi":"10.1002/alz.70249","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"40346724","source_url":"https://pubmed.ncbi.nlm.nih.gov/40346724/","study_design":null,"title":"Multisystem failure, tipping points, and risk of Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/education-and-genetic-risk-modulate-hippocampal-structure-in-27699079","doi":"10.14336/ad.2016.0305","journal":"Aging and disease","n_participants":null,"pmid":"27699079","source_url":"https://pubmed.ncbi.nlm.nih.gov/27699079/","study_design":null,"title":"Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer's Disease","title_match":false,"year":2016},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/quantitative-estimate-of-cognitive-resilience-and-its-medical-and-37926851","doi":"10.1186/s13195-023-01329-z","journal":"Alzheimer's research & therapy","n_participants":844,"pmid":"37926851","source_url":"https://pubmed.ncbi.nlm.nih.gov/37926851/","study_design":null,"title":"Quantitative estimate of cognitive resilience and its medical and genetic associations","title_match":false,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/regional-tau-pathology-and-loneliness-in-cognitively-normal-older-30563962","doi":"10.1038/s41398-018-0345-x","journal":"Translational psychiatry","n_participants":null,"pmid":"30563962","source_url":"https://pubmed.ncbi.nlm.nih.gov/30563962/","study_design":null,"title":"Regional tau pathology and loneliness in cognitively normal older adults","title_match":false,"year":2018},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/air-pollution-is-associated-with-faster-cognitive-decline-in-37106569","doi":"10.1002/acn3.51779","journal":"Annals of clinical and translational neurology","n_participants":269,"pmid":"37106569","source_url":"https://pubmed.ncbi.nlm.nih.gov/37106569/","study_design":"longitudinal study","title":"Air pollution is associated with faster cognitive decline in Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/long-term-exposure-to-low-level-air-pollution-genetic-susceptibility-35849335","doi":"10.1093/ije/dyac146","journal":"International journal of epidemiology","n_participants":447,"pmid":"35849335","source_url":"https://pubmed.ncbi.nlm.nih.gov/35849335/","study_design":null,"title":"Long-term exposure to low-level air pollution, genetic susceptibility and risk of dementia","title_match":false,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/ozone-and-particulate-matter-exposure-and-alzheimer-s-disease-a-32568209","doi":"10.3233/jad-200435","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"32568209","source_url":"https://pubmed.ncbi.nlm.nih.gov/32568209/","study_design":null,"title":"Ozone and Particulate Matter Exposure and Alzheimer's Disease: A Review of Human and Animal Studies","title_match":false,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/effects-of-apoe4-on-omega-3-brain-metabolism-across-the-lifespan-38609814","doi":"10.1016/j.tem.2024.03.003","journal":"Trends in endocrinology and metabolism: TEM","n_participants":null,"pmid":"38609814","source_url":"https://pubmed.ncbi.nlm.nih.gov/38609814/","study_design":null,"title":"Effects of APOE4 on omega-3 brain metabolism across the lifespan","title_match":true,"year":2024},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/dementia-and-osteoporosis-in-a-geriatric-population-is-there-a-common-28567345","doi":"10.5312/wjo.v8.i5.412","journal":"World journal of orthopedics","n_participants":null,"pmid":"28567345","source_url":"https://pubmed.ncbi.nlm.nih.gov/28567345/","study_design":null,"title":"Dementia and osteoporosis in a geriatric population: Is there a common link?","title_match":false,"year":2017},{"alzhub_score":63,"alzhub_url":"https://alzhub.org/study/interactions-between-dietary-patterns-and-genetic-factors-in-relation-34632537","doi":"10.1007/s00394-021-02688-9","journal":"European journal of nutrition","n_participants":null,"pmid":"34632537","source_url":"https://pubmed.ncbi.nlm.nih.gov/34632537/","study_design":"cohort study","title":"Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds","title_match":false,"year":2022},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/identification-of-chlamydia-pneumoniae-and-nlrp3-inflammasome-41571675","doi":"10.1038/s41467-026-68580-4","journal":"Nature communications","n_participants":null,"pmid":"41571675","source_url":"https://pubmed.ncbi.nlm.nih.gov/41571675/","study_design":null,"title":"Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina","title_match":false,"year":2026},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/gut-brain-relationship-in-dementia-and-alzheimer-s-disease-impact-on-40712930","doi":"10.1016/j.arr.2025.102843","journal":"Ageing research reviews","n_participants":null,"pmid":"40712930","source_url":"https://pubmed.ncbi.nlm.nih.gov/40712930/","study_design":null,"title":"Gut-brain relationship in dementia and Alzheimer's disease: Impact on stress and immunity","title_match":false,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/apoe4-promotes-cerebrovascular-fibrosis-and-amyloid-deposition-via-a-40964350","doi":"10.1101/2025.09.04.674192","journal":"bioRxiv : the preprint server for biology","n_participants":null,"pmid":"40964350","source_url":"https://pubmed.ncbi.nlm.nih.gov/40964350/","study_design":null,"title":"APOE4 promotes cerebrovascular fibrosis and amyloid deposition via a pericyte-to-myofibroblast transition","title_match":true,"year":2025},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/astrocytic-apoe4-removal-confers-cerebrovascular-protection-despite-36922879","doi":"10.1186/s13024-023-00610-x","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"36922879","source_url":"https://pubmed.ncbi.nlm.nih.gov/36922879/","study_design":null,"title":"Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy","title_match":true,"year":2023},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/leaky-memories-impact-of-apoe4-on-blood-brain-barrier-and-dementia-32600092","doi":"10.1177/0271678x20938146","journal":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","n_participants":null,"pmid":"32600092","source_url":"https://pubmed.ncbi.nlm.nih.gov/32600092/","study_design":null,"title":"Leaky memories: Impact of APOE4 on blood-brain barrier and dementia","title_match":true,"year":2020},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/a-pericyte-to-myofibroblast-transition-links-apoe4-to-cerebrovascular-42785300","doi":"10.1016/j.cell.2026.08.058","journal":"Cell","n_participants":null,"pmid":"42785300","source_url":"https://pubmed.ncbi.nlm.nih.gov/42785300/","study_design":null,"title":"A pericyte-to-myofibroblast transition links APOE4 to cerebrovascular degeneration","title_match":true,"year":2026},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/the-vascular-risk-factors-and-vascular-neuropathology-in-subjects-35128731","doi":"10.1002/gps.5683","journal":"International journal of geriatric psychiatry","n_participants":363,"pmid":"35128731","source_url":"https://pubmed.ncbi.nlm.nih.gov/35128731/","study_design":null,"title":"The vascular risk factors and vascular neuropathology in subjects with autopsy-confirmed dementia with Lewy bodies","title_match":false,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/older-adults-with-reduced-cerebrovascular-reactivity-exhibit-high-38579393","doi":"10.1016/j.neurobiolaging.2024.03.006","journal":"Neurobiology of aging","n_participants":125,"pmid":"38579393","source_url":"https://pubmed.ncbi.nlm.nih.gov/38579393/","study_design":null,"title":"Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/primary-tau-pathology-not-copathology-correlates-with-clinical-31999351","doi":"10.1093/jnen/nlz141","journal":"Journal of neuropathology and experimental neurology","n_participants":null,"pmid":"31999351","source_url":"https://pubmed.ncbi.nlm.nih.gov/31999351/","study_design":null,"title":"Primary Tau Pathology, Not Copathology, Correlates With Clinical Symptoms in PSP and CBD","title_match":false,"year":2020},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/disentangling-and-quantifying-the-relative-cognitive-impact-of-38520489","doi":"10.1007/s00401-024-02716-y","journal":"Acta neuropathologica","n_participants":6262,"pmid":"38520489","source_url":"https://pubmed.ncbi.nlm.nih.gov/38520489/","study_design":null,"title":"Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies","title_match":false,"year":2024},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-deposition-patterns-in-alzheimer-s-disease-41165827","doi":"10.1007/s00401-025-02952-w","journal":"Acta neuropathologica","n_participants":null,"pmid":"41165827","source_url":"https://pubmed.ncbi.nlm.nih.gov/41165827/","study_design":null,"title":"Alpha-synuclein deposition patterns in Alzheimer's disease: association with cortical amyloid beta and variable tau load","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/limbic-alzheimer-s-co-pathology-in-multiple-system-atrophy-is-40968282","doi":"10.1007/s00401-025-02940-0","journal":"Acta neuropathologica","n_participants":70,"pmid":"40968282","source_url":"https://pubmed.ncbi.nlm.nih.gov/40968282/","study_design":null,"title":"Limbic Alzheimer's co-pathology in multiple system atrophy is associated with cognitive impairment and diagnostic inaccuracy","title_match":false,"year":2025},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/tmem106b-is-a-selective-modulator-of-tdp-43-pathology-in-alzheimer-s-42720122","doi":"10.1002/alz.71713","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":2604,"pmid":"42720122","source_url":"https://pubmed.ncbi.nlm.nih.gov/42720122/","study_design":null,"title":"TMEM106B is a selective modulator of TDP-43 pathology in Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":39,"alzhub_url":"https://alzhub.org/study/apoe-apoe-receptors-and-the-synapse-in-alzheimer-s-disease-28057414","doi":"10.1016/j.tem.2016.12.001","journal":"Trends in endocrinology and metabolism: TEM","n_participants":null,"pmid":"28057414","source_url":"https://pubmed.ncbi.nlm.nih.gov/28057414/","study_design":null,"title":"ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease","title_match":false,"year":2017},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/racial-and-ethnic-disparities-in-dementia-risk-among-individuals-with-30005921","doi":"10.1016/j.jagp.2018.05.011","journal":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","n_participants":819,"pmid":"30005921","source_url":"https://pubmed.ncbi.nlm.nih.gov/30005921/","study_design":null,"title":"Racial and Ethnic Disparities in Dementia Risk Among Individuals With Low Education","title_match":false,"year":2018},{"alzhub_score":54,"alzhub_url":"https://alzhub.org/study/why-inclusion-matters-for-alzheimer-s-disease-biomarker-discovery-in-33427747","doi":"10.3233/jad-201318","journal":"Journal of Alzheimer's disease : JAD","n_participants":113,"pmid":"33427747","source_url":"https://pubmed.ncbi.nlm.nih.gov/33427747/","study_design":null,"title":"Why Inclusion Matters for Alzheimer's Disease Biomarker Discovery in Plasma","title_match":false,"year":2021},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/racial-and-ethnic-differences-in-the-population-attributable-38232335","doi":"10.1212/wnl.0000000000208116","journal":"Neurology","n_participants":91881,"pmid":"38232335","source_url":"https://pubmed.ncbi.nlm.nih.gov/38232335/","study_design":"cohort study","title":"Racial and Ethnic Differences in the Population-Attributable Fractions of Alzheimer Disease and Related Dementias","title_match":false,"year":2024},{"alzhub_score":61,"alzhub_url":"https://alzhub.org/study/risk-of-alzheimer-s-disease-and-related-dementia-by-sex-and-race-34882963","doi":"10.1002/alz.12528","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":16410,"pmid":"34882963","source_url":"https://pubmed.ncbi.nlm.nih.gov/34882963/","study_design":null,"title":"Risk of Alzheimer's disease and related dementia by sex and race/ethnicity: The Multiethnic Cohort Study","title_match":false,"year":2022},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/apoe-effects-on-late-life-cognitive-trajectories-in-diverse-racial-35243969","doi":"10.1017/s1355617722000030","journal":"Journal of the International Neuropsychological Society : JINS","n_participants":297,"pmid":"35243969","source_url":"https://pubmed.ncbi.nlm.nih.gov/35243969/","study_design":"longitudinal study","title":"APOE Effects on Late Life Cognitive Trajectories in Diverse Racial/Ethnic Groups","title_match":false,"year":2023},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/longitudinal-plasma-biomarkers-and-multimodal-pet-across-apoe-4-19abfe03","doi":"10.21203/rs.3.rs-11294615/v1","journal":"Research Square","n_participants":60,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11294615/v1","study_design":"longitudinal study","title":"Longitudinal plasma biomarkers and multimodal PET across APOE \u03b54 genotypes: a prospective cohort study","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/brain-derived-ptau217-and-plasma-proteomic-profiles-across-cognitive-b635ff16","doi":"10.64898/2026.10.26.26366533","journal":"medRxiv","n_participants":786,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.26.26366533","study_design":null,"title":"Brain-Derived pTau217 and Plasma Proteomic Profiles Across Cognitive and Dementia Groups in Congolese Older Adults","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/associations-of-genetic-predisposition-to-alzheimers-disease-with-a6466441","doi":"10.21203/rs.3.rs-11220681/v1","journal":"Research Square","n_participants":3947,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11220681/v1","study_design":null,"title":"Associations of genetic predisposition to Alzheimer\u2019s disease with blood-based biomarkers: a community-based study","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/synuclein-seed-amplification-status-modifies-the-relationship-between-af4554ea","doi":"10.21203/rs.3.rs-11271891/v1","journal":"Research Square","n_participants":193,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11271891/v1","study_design":"cross-sectional","title":"\u03b1-Synuclein Seed Amplification Status Modifies the Relationship Between Plasma p-tau217, Amyloid and Fibrillar Tau","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/multimodal-mediators-connecting-apoe4-to-dementia-e0e0d44c","doi":"10.21203/rs.3.rs-11445203/v1","journal":"Research Square","n_participants":58876,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11445203/v1","study_design":null,"title":"Multimodal mediators connecting APOE4 to dementia","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/comparative-analysis-of-plasma-ptau217-nfl-and-eight-modifiable-risk-d52f05ae","doi":"10.64898/2026.10.15.26365615","journal":"medRxiv","n_participants":3935,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.15.26365615","study_design":null,"title":"Comparative analysis of plasma pTau217, NfL and eight modifiable risk scores for 11-year dementia prediction in the HUNT Study","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/tau-pet-subtype-modifies-the-association-between-plasma-p-tau217-and-ada7a142","doi":"10.64898/2026.09.25.26363629","journal":"medRxiv","n_participants":396,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.25.26363629","study_design":"cross-sectional","title":"Tau-PET subtype modifies the association between plasma p-tau217 and memory in Alzheimer\u2019s disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/plasma-fibrinogen-correlates-with-a-clearance-of-monocytes-and-ad-074ef6d2","doi":"10.21203/rs.3.rs-10658330/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10658330/v1","study_design":"cross-sectional","title":"Plasma Fibrinogen Correlates with A\u03b2 Clearance of monocytes and AD Biomarkers in Cognitively Normal Individuals","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/quantitative-systems-pharmacology-analysis-of-amyloid-aggregation-and-a02492d7","doi":"10.21203/rs.3.rs-10570608/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10570608/v1","study_design":"clinical trial","title":"Quantitative Systems Pharmacology Analysis of Amyloid Aggregation and Hippocampal Atrophy Trajectories in Alzheimer\u2019s Disease by APOE4 Genotype and Valiltramiprosate/ALZ-801 Treatment","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/epigenetic-clock-trajectories-and-brain-health-in-midlife-23452582","doi":"10.64898/2026.07.16.26358251","journal":"medRxiv","n_participants":2833,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.16.26358251","study_design":null,"title":"Epigenetic Clock Trajectories and Brain Health in Midlife","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/proteomic-biomarkers-of-cognitive-function-apoe-4-status-and-dementia-2d2f572b","doi":"10.64898/2026.01.27.26344912","journal":"medRxiv","n_participants":14258,"pmid":null,"source_url":"https://doi.org/10.64898/2026.01.27.26344912","study_design":null,"title":"Proteomic biomarkers of cognitive function, APOE \u03b54 status, and dementia in Generation Scotland","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/apoe-genotype-and-fluid-biomarkers-of-blood-brain-barrier-integrity-a-9a749401","doi":"10.64898/2026.09.27.26364123","journal":"medRxiv","n_participants":5375,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.27.26364123","study_design":"systematic review","title":"APOE Genotype and Fluid Biomarkers of Blood-Brain Barrier Integrity: A Systematic Review and Meta-Analysis","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/apoe4-and-psychosis-in-neurodegenerative-and-non-neurodegenerative-1d706ebb","doi":"10.20944/preprints202610.2617.v1","journal":"Preprints.org","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.20944/preprints202610.2617.v1","study_design":null,"title":"ApoE4 and Psychosis in Neurodegenerative and Non-Neurodegenerative Disease: A Scoping Review","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/genetic-susceptibility-to-lewy-body-disease-and-the-distribution-of-87ec1c1b","doi":"10.64898/2026.10.21.26366146","journal":"medRxiv","n_participants":1362,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.21.26366146","study_design":"meta-analysis","title":"Genetic susceptibility to Lewy body disease and the distribution of Lewy pathology","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/spatial-proximity-to-ad-pathology-defines-cell-type-and-genotype-06f6a958","doi":"10.64898/2026.10.15.759523","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.15.759523","study_design":null,"title":"Spatial proximity to AD pathology defines cell-type and genotype-specific characteristics in human AD hippocampus","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/reproductive-aging-fsh-and-apolipoprotein-biology-in-alzheimers-afc592dc","doi":"10.20944/preprints202604.0104.v4","journal":"Preprints.org","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.20944/preprints202604.0104.v4","study_design":null,"title":"Reproductive Aging, FSH, and Apolipoprotein Biology in Alzheimer\u2019s Disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/location-specific-longitudinal-patterns-of-subcortical-and-lobar-1e2a59ae","doi":"10.64898/2026.10.12.26365339","journal":"medRxiv","n_participants":1146,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.12.26365339","study_design":"longitudinal study","title":"Location-specific Longitudinal Patterns of Subcortical and Lobar Cerebral Microhemorrhages in Preclinical Alzheimer Disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/clinical-utility-of-plasma-apoe-proteotyping-for-alzheimers-disease-4dfb2d6c","doi":"10.64898/2026.10.08.26364972","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.08.26364972","study_design":"cross-sectional","title":"Clinical utility of plasma APOE proteotyping for Alzheimer\u2019s disease risk and prognosis","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/mthfr-677c-t-produces-distinct-prodromal-disease-signatures-in-a-6da14e5f","doi":"10.21203/rs.3.rs-11166891/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-11166891/v1","study_design":null,"title":"MTHFR*677C>T produces distinct prodromal disease signatures in a mouse model of late-onset Alzheimer\u2019s disease","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/a-sphingomyelin-cholesterol-complex-regulates-tlr4-activation-in-0ceb195a","doi":"10.64898/2026.09.10.750647","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.10.750647","study_design":null,"title":"A sphingomyelin-cholesterol complex regulates TLR4 activation in microglia","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/apoe4-attenuates-early-trem2-mediated-microglial-responses-and-ef1dd141","doi":"10.21203/rs.3.rs-10429506/v1","journal":"Research Square","n_participants":129,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10429506/v1","study_design":"longitudinal study","title":"APOE\u03b54 attenuates early TREM2-mediated microglial responses and influences disease trajectories in dementia with Lewy bodies","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/amyloid-tau-pet-fusion-reveals-covarying-network-territories-linked-f355a22f","doi":"10.64898/2026.08.11.744123","journal":"bioRxiv","n_participants":320,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.11.744123","study_design":null,"title":"Amyloid-Tau PET Fusion Reveals Covarying Network Territories Linked to Disease Stage, Cognition, and APOE4 in Alzheimer\u2019s Disease","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/when-is-amyloid-really-cleared-substantial-discordance-between-fc03ab7d","doi":"10.64898/2026.10.03.26364642","journal":"medRxiv","n_participants":15,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.03.26364642","study_design":null,"title":"When Is Amyloid Really Cleared? Substantial Discordance Between Centiloid Quantitation and Visual Reads of Amyloid PET after Amyloid-Targeting Therapy","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/orthogonal-contributions-of-genetic-clinical-and-social-determinants-b68cebbb","doi":"10.64898/2026.07.07.26357509","journal":"medRxiv","n_participants":2276,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.07.26357509","study_design":"cohort study","title":"Orthogonal Contributions of Genetic, Clinical, and Social Determinants of Health Risk Burdens on Alzheimer\u2019s Disease Pathophysiology","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/investigating-the-amyloid-tau-neurodegeneration-framework-in-b01fb94a","doi":"10.64898/2025.12.11.25341830","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2025.12.11.25341830","study_design":null,"title":"Investigating the Amyloid-Tau-Neurodegeneration Framework in Alzheimer\u2019s Disease Using Semi-Supervised Multimodal Imaging Data Fusion","title_match":false,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/apoe-4-carrier-status-and-cognitive-decline-in-mild-to-moderate-8aa9046f","doi":"10.64898/2026.09.27.26364131","journal":"medRxiv","n_participants":370,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.27.26364131","study_design":"clinical trial","title":"APOE \u03b54 Carrier Status and Cognitive Decline in Mild-to-Moderate Alzheimer\u2019s Disease: A Linear Mixed-Effects Analysis of the Placebo Arm of EXPEDITION 1","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/amyloid-and-tau-cerebrospinal-fluid-biomarker-normalization-in-a-1d9e787e","doi":"10.21203/rs.3.rs-10778388/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10778388/v1","study_design":null,"title":"Amyloid and Tau Cerebrospinal Fluid Biomarker Normalization in a Patient with Alzheimer\u2019s Disease treated with Lecanemab: A Case Report","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/real-world-characterization-of-amyloid-related-imaging-abnormalities-4202aa20","doi":"10.64898/2026.01.23.26344739","journal":"medRxiv","n_participants":468,"pmid":null,"source_url":"https://doi.org/10.64898/2026.01.23.26344739","study_design":"cohort study","title":"Real-World Characterization of Amyloid-Related Imaging Abnormalities (ARIA) in Lecanemab Treatment at an Academic Health System","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/anti-amyloid-immunotherapy-drives-apoe4-specific-increases-in-glial-922ec944","doi":"10.64898/2026.06.26.734793","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.06.26.734793","study_design":null,"title":"Anti-amyloid immunotherapy drives APOE4 specific increases in glial reactivity, perivascular immune activation, and ARIA-like events","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/intravenous-anti-a-immunotherapy-acutely-increases-cerebral-amyloid-5846ffcd","doi":"10.64898/2026.02.09.704876","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.02.09.704876","study_design":null,"title":"Intravenous anti-A\u03b2 immunotherapy acutely increases cerebral amyloid angiopathy and vascular damages in APOE4 mice","title_match":true,"year":2026},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/early-binding-of-anti-amyloid-antibodies-to-caa-drives-complement-7ec97b6f","doi":"10.64898/2026.03.04.709591","journal":"Molecular neurodegeneration","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.03.04.709591","study_design":null,"title":"Early Binding of Anti-Amyloid Antibodies to CAA Drives Complement Activation, Inflammation and ARIA in Mice","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/scfv-h3d6-prevents-bapineuzumab-induced-hemorrhagic-events-in-the-343d96ed","doi":"10.20944/preprints202511.0180.v1","journal":"Preprints.org","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.20944/preprints202511.0180.v1","study_design":null,"title":"ScFv-h3D6 Prevents Bapineuzumab-Induced Hemorrhagic Events in the APP23 Mouse Model of Alzheimer\u2019s Disease","title_match":false,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/plasma-ptau-181-exhibits-flat-longitudinal-trajectories-and-weak-eaeb6aee","doi":"10.21203/rs.3.rs-8204349/v1","journal":"Research Square","n_participants":2523,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-8204349/v1","study_design":"cross-sectional","title":"Plasma pTau-181 Exhibits Flat Longitudinal Trajectories and Weak Cognitive Correlation in UK Biobank: Implications for Anti-Tau Antibody Trial Failures","title_match":false,"year":2025},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/plasma-proteomic-analysis-of-apoe-4-homozygotes-identifies-827b8960","doi":"10.64898/2026.02.14.26346321","journal":"medRxiv","n_participants":413,"pmid":null,"source_url":"https://doi.org/10.64898/2026.02.14.26346321","study_design":null,"title":"Plasma Proteomic Analysis of APOE \u03b54 Homozygotes Identifies Preclinical Alzheimer\u2019s Disease Alterations Potentially Modulated by Semaglutide","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/randomized-metformin-and-cognitive-outcomes-in-the-diabetes-f474ce0b","doi":"10.64898/2026.08.05.26359234","journal":"medRxiv","n_participants":1483,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.05.26359234","study_design":"longitudinal study","title":"Randomized metformin and cognitive outcomes in the Diabetes Prevention Program Outcomes Study","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/age-related-speech-in-noise-hearing-loss-in-parkinsons-disease-and-a3ec8995","doi":"10.64898/2026.06.08.26355175","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.06.08.26355175","study_design":"longitudinal study","title":"Age-Related Speech-in-Noise Hearing Loss in Parkinson\u2019s Disease and APOE E4 Carriers","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/dna-polymerase-kappa-supports-repair-associated-dna-synthesis-and-f0e1911c","doi":"10.64898/2026.10.01.756094","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.01.756094","study_design":null,"title":"DNA polymerase kappa supports repair-associated DNA synthesis and neuronal genome resilience","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/biopsychosocial-risk-factors-for-alzheimers-disease-and-related-a9a32f32","doi":"10.64898/2026.05.08.26352762","journal":"medRxiv","n_participants":3552,"pmid":null,"source_url":"https://doi.org/10.64898/2026.05.08.26352762","study_design":null,"title":"Biopsychosocial risk factors for Alzheimer\u2019s disease and related dementias in UK immigrants from the Middle East and North Africa (MENA)","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/prenatal-pesticide-exposure-and-early-alzheimer-disease-related-71e2ee29","doi":"10.64898/2026.05.13.26352896","journal":"medRxiv","n_participants":179,"pmid":null,"source_url":"https://doi.org/10.64898/2026.05.13.26352896","study_design":"cohort study","title":"Prenatal Pesticide Exposure and Early Alzheimer Disease-Related Biomarker and Cognitive Changes in Midlife","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/associations-of-lifestyle-factors-and-genetic-risk-with-risk-and-rate-dc6dfca0","doi":"10.31234/osf.io/9tsj3_v1","journal":"PsyArXiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.31234/osf.io/9tsj3_v1","study_design":null,"title":"Associations of lifestyle factors and genetic risk with risk and rate advancement periods of dementia","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/the-microbial-soy-metabolite-s-equol-mitigates-cadmium-neurotoxicity-026f9a99","doi":"10.64898/2026.10.01.756095","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.01.756095","study_design":null,"title":"The microbial soy metabolite S-equol mitigates cadmium neurotoxicity in mice","title_match":false,"year":2026},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/gut-microbial-metabolism-as-a-dynamic-interface-in-neurodegenerative-99d180f0","doi":"10.20944/preprints202608.0510.v1","journal":"Metabolites","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.20944/preprints202608.0510.v1","study_design":"longitudinal study","title":"Gut Microbial Metabolism as a Dynamic Interface in Neurodegenerative Diseases","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/apoe4-reduction-in-vascular-associated-fibroblasts-decreases-cerebral-e9af705a","doi":"10.64898/2026.10.02.756327","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.10.02.756327","study_design":null,"title":"APOE4 reduction in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and associated vascular dysfunction","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/ion-modulation-restores-local-synaptic-function-in-apoe4-neuronal-816ff7e2","doi":"10.64898/2026.09.08.750089","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.08.750089","study_design":null,"title":"Ion modulation restores local synaptic function in APOE4 neuronal networks despite persistent impairments in global network organization","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/curation-of-mini-mental-state-examination-mmse-scores-in-the-va-c1897ac7","doi":"10.64898/2026.07.14.26358064","journal":"medRxiv","n_participants":49555,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.14.26358064","study_design":"cross-sectional","title":"Curation of Mini Mental State Examination (MMSE) Scores in the VA Million Veteran Program (MVP): Applications for Cognitive Aging Research","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/effect-of-intensive-vs-standard-blood-pressure-control-according-to-e75ce35c","doi":"10.64898/2026.07.02.26357167","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.02.26357167","study_design":"randomized controlled trial","title":"Effect of Intensive vs Standard Blood Pressure Control According to APOE \u03b54 Genotype: A Secondary Analysis of SPRINT","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/detecting-preclinical-alzheimers-disease-risk-in-cognitively-normal-7e9f0fc0","doi":"10.64898/2026.01.15.26344226","journal":"medRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.01.15.26344226","study_design":null,"title":"Detecting Preclinical Alzheimer\u2019s Disease Risk in Cognitively Normal Adults Using Speech Acoustics: Validation with Plasma p-Tau217 and APOE-\u03b54 Status","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/phenome-wide-and-proteomic-analysis-of-apoe-alleles-across-different-600a905d","doi":"10.64898/2026.09.26.26364080","journal":"medRxiv","n_participants":181880,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.26.26364080","study_design":null,"title":"Phenome-wide and proteomic analysis of APOE alleles across different ancestries in the All of Us Research Program","title_match":false,"year":2026},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/clinical-phenotype-of-apoe-4-carriers-in-patients-with-vascular-88426919","doi":"10.12688/f1000research.188901.1","journal":"F1000Res","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.12688/f1000research.188901.1","study_design":"cross-sectional","title":"Clinical Phenotype of Apoe \u01904 Carriers In Patients With Vascular Dementia: A Cross-Sectional Study From Indonesia","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/trisomy-21-cerebral-organoids-exhibit-alzheimers-disease-amyloid-and-c6cd8c6a","doi":"10.64898/2026.07.01.735908","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.07.01.735908","study_design":null,"title":"Trisomy 21 cerebral organoids exhibit Alzheimer\u2019s disease amyloid and apolipoprotein E co-pathologies","title_match":false,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/progressive-behavioral-and-cognitive-decline-in-drosophila-harboring-bb67e0bb","doi":"10.64898/2026.09.08.750261","journal":"bioRxiv","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.64898/2026.09.08.750261","study_design":null,"title":"Progressive behavioral and cognitive decline in Drosophila harboring AD- associated APOE4 variants","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/proteomic-signatures-of-apoe-4-across-human-tissues-and-cell-types-in-04732701","doi":"10.64898/2026.08.27.746928","journal":"bioRxiv","n_participants":1691,"pmid":null,"source_url":"https://doi.org/10.64898/2026.08.27.746928","study_design":null,"title":"Proteomic signatures of APOE \u03b54 across human tissues and cell types in Alzheimer\u2019s disease","title_match":true,"year":2026},{"alzhub_score":16,"alzhub_url":"https://alzhub.org/study/stable-brain-architecture-but-flexible-dynamics-distinct-structure-c3c57035","doi":"10.21203/rs.3.rs-10563433/v1","journal":"Research Square","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.21203/rs.3.rs-10563433/v1","study_design":null,"title":"Stable brain architecture but flexible dynamics: distinct structure - function coupling signatures link aging and genetic Alzheimer's risk to cognitive decline in 34,067 adults","title_match":false,"year":2026},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/population-based-blood-screening-for-pre-clinical-alzheimers-disease-ab059739","doi":"10.1136/jnnp-2022-abn.297","journal":"Journal of Neurology Neurosurgery & Psychiatry","n_participants":543,"pmid":null,"source_url":"https://doi.org/10.1136/jnnp-2022-abn.297","study_design":null,"title":"Population-based blood screening for pre-clinical Alzheimer\u2019s disease: a British birth cohort at age 70","title_match":false,"year":2022},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/cytoskeleton-proteins-in-csf-distinguish-frontotemporal-dementia-from-10822437","doi":"10.1212/wnl.54.10.1960","journal":"Neurology","n_participants":18,"pmid":"10822437","source_url":"https://pubmed.ncbi.nlm.nih.gov/10822437/","study_design":null,"title":"Cytoskeleton proteins in CSF distinguish frontotemporal dementia from AD","title_match":false,"year":2000},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-4-and-cerebral-hemorrhage-associated-with-amyloid-7654074","doi":"10.1002/ana.410380219","journal":"Annals of Neurology","n_participants":15,"pmid":"7654074","source_url":"https://pubmed.ncbi.nlm.nih.gov/7654074/","study_design":null,"title":"Apolipoprotein E \u03f54 and cerebral hemorrhage associated with amyloid angiopathy","title_match":true,"year":1995},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/isoform-specific-binding-of-apolipoprotein-e-to-beta-amyloid-8089103","doi":"10.1016/s0021-9258(17)31529-6","journal":"Journal of Biological Chemistry","n_participants":null,"pmid":"8089103","source_url":"https://pubmed.ncbi.nlm.nih.gov/8089103/","study_design":null,"title":"Isoform-specific binding of apolipoprotein E to beta-amyloid","title_match":false,"year":1994},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/long-acting-intranasal-insulin-detemir-improves-cognition-for-adults-25374101","doi":"10.3233/jad-141791","journal":"Journal of Alzheimer s Disease","n_participants":20,"pmid":"25374101","source_url":"https://pubmed.ncbi.nlm.nih.gov/25374101/","study_design":null,"title":"Long-Acting Intranasal Insulin Detemir Improves Cognition for Adults with Mild Cognitive Impairment or Early-Stage Alzheimer's Disease Dementia","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/herpes-simplex-virus-type-1-dna-is-located-within-alzheimer-s-disease-18973185","doi":"10.1002/path.2449","journal":"The Journal of Pathology","n_participants":null,"pmid":"18973185","source_url":"https://pubmed.ncbi.nlm.nih.gov/18973185/","study_design":null,"title":"Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques","title_match":false,"year":2008},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/association-of-gwaslinked-loci-with-lateonset-alzheimer-s-disease-in-23232270","doi":"10.1016/j.jalz.2012.08.007","journal":"Alzheimer s & Dementia","n_participants":1224,"pmid":"23232270","source_url":"https://pubmed.ncbi.nlm.nih.gov/23232270/","study_design":null,"title":"Association of GWAS\u2010linked loci with late\u2010onset Alzheimer's disease in a northern Han Chinese population","title_match":false,"year":2012},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/gwas-of-longitudinal-amyloid-accumulation-on18f-florbetapir-pet-in-26268530","doi":"10.1093/brain/awv231","journal":"Brain","n_participants":null,"pmid":"26268530","source_url":"https://pubmed.ncbi.nlm.nih.gov/26268530/","study_design":"longitudinal study","title":"GWAS of longitudinal amyloid accumulation on18F-florbetapir PET in Alzheimer\u2019s disease implicates microglial activation geneIL1RAP","title_match":false,"year":2015},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/risk-factors-for-amyloid-deposition-in-healthy-aging-23553344","doi":"10.1001/jamaneurol.2013.1342","journal":"JAMA Neurology","n_participants":null,"pmid":"23553344","source_url":"https://pubmed.ncbi.nlm.nih.gov/23553344/","study_design":"cross-sectional","title":"Risk Factors for \u03b2-Amyloid Deposition in Healthy Aging","title_match":false,"year":2013},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/inflammation-in-alzheimers-disease-insights-from-immunotherapy-23983027","doi":"10.1093/brain/awt231","journal":"Brain","n_participants":39,"pmid":"23983027","source_url":"https://pubmed.ncbi.nlm.nih.gov/23983027/","study_design":null,"title":"Inflammation in Alzheimer\u2019s disease: insights from immunotherapy","title_match":false,"year":2013},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/o40405-aducanumab-biib037-an-antiamyloid-beta-monoclonal-antibody-in-204cb97e","doi":"10.1016/j.jalz.2015.07.367","journal":"Alzheimer s & Dementia","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1016/j.jalz.2015.07.367","study_design":null,"title":"O4\u201004\u201005: Aducanumab (BIIB037), an anti\u2010amyloid beta monoclonal antibody, in patients with prodromal or mild Alzheimer's disease: Interim results of a randomized, double\u2010blind, placebo\u2010controlled, phase 1b study","title_match":false,"year":2015},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/o41106-a-randomized-doubleblind-placebocontrolled-phase-2-study-to-a7c335d7","doi":"10.1016/j.jalz.2014.04.450","journal":"Alzheimer s & Dementia","n_participants":433,"pmid":null,"source_url":"https://doi.org/10.1016/j.jalz.2014.04.450","study_design":"clinical trial","title":"O4\u201011\u201006: A RANDOMIZED, DOUBLE\u2010BLIND, PLACEBO\u2010CONTROLLED PHASE 2 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF CRENEZUMAB IN PATIENTS WITH MILD TO MODERATE ALZHEIMER'S DISEASE","title_match":false,"year":2014},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/dt0103-efficacy-and-safety-of-gantenerumab-in-prodromal-alzheimer-s-f0473682","doi":"10.1016/j.jalz.2015.08.153","journal":"Alzheimer s & Dementia","n_participants":312,"pmid":null,"source_url":"https://doi.org/10.1016/j.jalz.2015.08.153","study_design":"clinical trial","title":"DT\u201001\u201003: Efficacy and safety of gantenerumab in prodromal Alzheimer's disease: Results from scarlet road\u2014a global, multicenter trial","title_match":false,"year":2015},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/decreased-melatonin-levels-in-postmortem-cerebrospinal-fluid-in-9920102","doi":"10.1210/jcem.84.1.5394","journal":"The Journal of Clinical Endocrinology & Metabolism","n_participants":29,"pmid":"9920102","source_url":"https://pubmed.ncbi.nlm.nih.gov/9920102/","study_design":null,"title":"Decreased Melatonin Levels in Postmortem Cerebrospinal Fluid in Relation to Aging, Alzheimer\u2019s Disease, and Apolipoprotein E-\u03b54/4 Genotype1","title_match":true,"year":1999},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/dietary-fats-and-the-risk-of-incident-alzheimer-disease-12580703","doi":"10.1001/archneur.60.2.194","journal":"Archives of Neurology","n_participants":131,"pmid":"12580703","source_url":"https://pubmed.ncbi.nlm.nih.gov/12580703/","study_design":null,"title":"Dietary Fats and the Risk of Incident Alzheimer Disease","title_match":false,"year":2003},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/association-between-features-of-the-insulin-resistance-syndrome-and-9366728","doi":"10.1136/bmj.315.7115.1045","journal":"BMJ","n_participants":980,"pmid":"9366728","source_url":"https://pubmed.ncbi.nlm.nih.gov/9366728/","study_design":null,"title":"Association between features of the insulin resistance syndrome and alzheimer's disease independently of apolipoprotein e4 phenotype: cross sectional population based study","title_match":true,"year":1997},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/traffic-related-air-pollution-apoe-4-status-and-neurodevelopmental-30073950","doi":"10.1289/ehp2246","journal":"Environmental Health Perspectives","n_participants":null,"pmid":"30073950","source_url":"https://pubmed.ncbi.nlm.nih.gov/30073950/","study_design":null,"title":"Traffic-Related Air Pollution, APOE \u03b54 Status, and Neurodevelopmental Outcomes among School Children Enrolled in the BREATHE Project (Catalonia, Spain)","title_match":true,"year":2018},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/alcohol-drinking-in-middle-age-and-subsequent-risk-of-mild-cognitive-15304383","doi":"10.1136/bmj.38181.418958.be","journal":"BMJ","n_participants":null,"pmid":"15304383","source_url":"https://pubmed.ncbi.nlm.nih.gov/15304383/","study_design":null,"title":"Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study","title_match":false,"year":2004},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/apoe-e4-genotype-predicts-severe-covid-19-in-the-uk-biobank-community-32451547","doi":"10.1093/gerona/glaa131","journal":"The Journals of Gerontology Series A","n_participants":16749,"pmid":"32451547","source_url":"https://pubmed.ncbi.nlm.nih.gov/32451547/","study_design":null,"title":"APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort","title_match":true,"year":2020},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/association-of-plasma-p-tau181-with-memory-decline-in-non-demented-cf62d2ac","doi":"10.1093/braincomms/fcab136","journal":"Brain Communications","n_participants":604,"pmid":null,"source_url":"https://doi.org/10.1093/braincomms/fcab136","study_design":"longitudinal study","title":"Association of plasma P-tau181 with memory decline in non-demented adults","title_match":false,"year":2021},{"alzhub_score":80,"alzhub_url":"https://alzhub.org/study/the-apoe-gene-is-related-with-exceptional-longevity-a-systematic-975b7ad3","doi":"10.1089/rej.2014.1605","journal":"Rejuvenation Research","n_participants":2776,"pmid":null,"source_url":"https://doi.org/10.1089/rej.2014.1605","study_design":"meta-analysis","title":"The ApoE Gene Is Related with Exceptional Longevity: A Systematic Review and Meta-Analysis","title_match":false,"year":2015},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/elevated-levels-of-ldl-c-are-associated-with-apoe4-but-not-with-the-aa9d6443","doi":"10.1177/1076029614568714","journal":"Clinical and Applied Thrombosis/Hemostasis","n_participants":400,"pmid":null,"source_url":"https://doi.org/10.1177/1076029614568714","study_design":null,"title":"Elevated Levels of LDL-C are Associated With ApoE4 but Not With the rs688 Polymorphism in the LDLR Gene","title_match":true,"year":2015},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/the-relationship-between-obstructive-sleep-apnea-syndrome-and-153a84d1","doi":"10.1159/000369560","journal":"Respiration","n_participants":73,"pmid":null,"source_url":"https://doi.org/10.1159/000369560","study_design":null,"title":"The Relationship between Obstructive Sleep Apnea Syndrome and Apolipoprotein E Genetic Variants","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/scp-apoe-scp-modulated-ainduced-neuroinflammation-in-alzheimer-s-6a932752","doi":"10.1111/jnc.13072","journal":"Journal of Neurochemistry","n_participants":null,"pmid":null,"source_url":"https://doi.org/10.1111/jnc.13072","study_design":null,"title":"APOE \u2010modulated A\u03b2\u2010induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective","title_match":false,"year":2015},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/associations-between-brain-inflammatory-profiles-and-human-32076055","doi":"10.1038/s41598-020-59869-5","journal":"Scientific reports","n_participants":154,"pmid":"32076055","source_url":"https://pubmed.ncbi.nlm.nih.gov/32076055/","study_design":null,"title":"Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E \u03b54 genotype","title_match":true,"year":2020},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/the-global-neurodegeneration-proteomics-consortium-biomarker-and-drug-40665048","doi":"10.1038/s41591-025-03834-0","journal":"Nature medicine","n_participants":null,"pmid":"40665048","source_url":"https://pubmed.ncbi.nlm.nih.gov/40665048/","study_design":null,"title":"The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/clinical-validation-of-the-precivityad2-blood-test-a-mass-38491912","doi":"10.1002/alz.13764","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":583,"pmid":"38491912","source_url":"https://pubmed.ncbi.nlm.nih.gov/38491912/","study_design":null,"title":"Clinical validation of the PrecivityAD2 blood test: A mass spectrometry-based test with algorithm combining %p-tau217 and A\u03b242/40 ratio to identify presence of brain amyloid","title_match":false,"year":2024},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/head-to-head-comparison-between-plasma-p-tau217-and-flortaucipir-pet-37740209","doi":"10.1186/s13195-023-01302-w","journal":"Alzheimer's research & therapy","n_participants":85,"pmid":"37740209","source_url":"https://pubmed.ncbi.nlm.nih.gov/37740209/","study_design":"longitudinal study","title":"Head-to-head comparison between plasma p-tau217 and flortaucipir-PET in amyloid-positive patients with cognitive impairment","title_match":false,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/clinical-value-of-plasma-alzpath-ptau217-immunoassay-for-assessing-38658136","doi":"10.1136/jnnp-2024-333467","journal":"Journal of neurology, neurosurgery, and psychiatry","n_participants":null,"pmid":"38658136","source_url":"https://pubmed.ncbi.nlm.nih.gov/38658136/","study_design":null,"title":"Clinical value of plasma ALZpath pTau217 immunoassay for assessing mild cognitive impairment","title_match":false,"year":2024},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/decreasing-body-mass-index-is-associated-with-cerebrospinal-fluid-29054536","doi":"10.1016/j.exger.2017.10.013","journal":"Experimental gerontology","n_participants":null,"pmid":"29054536","source_url":"https://pubmed.ncbi.nlm.nih.gov/29054536/","study_design":null,"title":"Decreasing body mass index is associated with cerebrospinal fluid markers of Alzheimer's pathology in MCI and mild dementia","title_match":false,"year":2017},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/association-of-plasma-p-tau181-with-memory-decline-in-non-demented-34222875","doi":"10.1093/braincomms/fcab136","journal":"Brain communications","n_participants":604,"pmid":"34222875","source_url":"https://pubmed.ncbi.nlm.nih.gov/34222875/","study_design":"longitudinal study","title":"Association of plasma P-tau181 with memory decline in non-demented adults","title_match":false,"year":2021},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/accuracy-of-plasma-a40-a42-and-p-tau181-to-detect-csf-alzheimer-s-37784138","doi":"10.1186/s13195-023-01319-1","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"37784138","source_url":"https://pubmed.ncbi.nlm.nih.gov/37784138/","study_design":null,"title":"Accuracy of plasma A\u03b240, A\u03b242, and p-tau181 to detect CSF Alzheimer's pathological changes in cognitively unimpaired subjects using the Lumipulse automated platform","title_match":false,"year":2023},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/apoe4-potentiates-amyloid-effects-on-longitudinal-tau-pathology-37749258","doi":"10.1038/s43587-023-00490-2","journal":"Nature aging","n_participants":94,"pmid":"37749258","source_url":"https://pubmed.ncbi.nlm.nih.gov/37749258/","study_design":"longitudinal study","title":"APOE\u03b54 potentiates amyloid \u03b2 effects on longitudinal tau pathology","title_match":true,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/acute-phase-markers-in-csf-reveal-inflammatory-changes-in-alzheimer-s-32882319","doi":"10.1016/j.pneurobio.2020.101904","journal":"Progress in neurobiology","n_participants":1291,"pmid":"32882319","source_url":"https://pubmed.ncbi.nlm.nih.gov/32882319/","study_design":null,"title":"Acute phase markers in CSF reveal inflammatory changes in Alzheimer's disease that intersect with pathology, APOE \u03b54, sex and age","title_match":true,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/homocysteine-metabolism-and-cerebrospinal-fluid-markers-for-alzheimer-19661622","doi":"10.3233/jad-2009-1187","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"19661622","source_url":"https://pubmed.ncbi.nlm.nih.gov/19661622/","study_design":null,"title":"Homocysteine metabolism and cerebrospinal fluid markers for Alzheimer's disease","title_match":false,"year":2009},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/associating-alzheimer-s-disease-pathology-with-its-cerebrospinal-35026840","doi":"10.1093/brain/awac013","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"35026840","source_url":"https://pubmed.ncbi.nlm.nih.gov/35026840/","study_design":null,"title":"Associating Alzheimer's disease pathology with its cerebrospinal fluid biomarkers","title_match":false,"year":2022},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/csf-biomarkers-of-immune-activation-and-alzheimer-s-disease-for-38569027","doi":"10.1126/sciadv.adk3674","journal":"Science advances","n_participants":298,"pmid":"38569027","source_url":"https://pubmed.ncbi.nlm.nih.gov/38569027/","study_design":null,"title":"CSF biomarkers of immune activation and Alzheimer's disease for predicting cognitive impairment risk in the elderly","title_match":false,"year":2024},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/csf-beta-amyloid-1-42-what-are-we-measuring-in-alzheimer-s-disease-25750918","doi":"10.1002/acn3.160","journal":"Annals of clinical and translational neurology","n_participants":69,"pmid":"25750918","source_url":"https://pubmed.ncbi.nlm.nih.gov/25750918/","study_design":null,"title":"CSF beta-amyloid 1-42 - what are we measuring in Alzheimer's disease?","title_match":false,"year":2015},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/apoe4-impact-on-soluble-and-insoluble-tau-pathology-is-mostly-39817469","doi":"10.1093/brain/awaf016","journal":"Brain : a journal of neurology","n_participants":1370,"pmid":"39817469","source_url":"https://pubmed.ncbi.nlm.nih.gov/39817469/","study_design":"cross-sectional","title":"APOE4 impact on soluble and insoluble tau pathology is mostly influenced by amyloid-\u03b2","title_match":true,"year":2025},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/blood-phosphorylated-tau-181-as-a-biomarker-for-amyloid-burden-on-35491781","doi":"10.3233/jad-215639","journal":"Journal of Alzheimer's disease : JAD","n_participants":18,"pmid":"35491781","source_url":"https://pubmed.ncbi.nlm.nih.gov/35491781/","study_design":null,"title":"Blood Phosphorylated Tau 181 as a Biomarker for Amyloid Burden on Brain PET in Cognitively Healthy Adults","title_match":false,"year":2022},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/plasma-phospho-tau217-as-a-predictive-biomarker-for-alzheimer-s-39743558","doi":"10.1186/s13195-024-01655-w","journal":"Alzheimer's research & therapy","n_participants":234,"pmid":"39743558","source_url":"https://pubmed.ncbi.nlm.nih.gov/39743558/","study_design":null,"title":"Plasma phospho-tau217 as a predictive biomarker for Alzheimer's disease in a large south American cohort","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/low-levels-of-cerebrospinal-fluid-complement-3-and-factor-h-predict-25478014","doi":"10.1186/alzrt266","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"25478014","source_url":"https://pubmed.ncbi.nlm.nih.gov/25478014/","study_design":"longitudinal study","title":"Low levels of cerebrospinal fluid complement 3 and factor H predict faster cognitive decline in mild cognitive impairment","title_match":false,"year":2014},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/associations-among-plasma-mri-and-amyloid-pet-biomarkers-of-alzheimer-38747525","doi":"10.1002/alz.13835","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":299,"pmid":"38747525","source_url":"https://pubmed.ncbi.nlm.nih.gov/38747525/","study_design":null,"title":"Associations among plasma, MRI, and amyloid PET biomarkers of Alzheimer's disease and related dementias and the impact of health-related comorbidities in a community-dwelling cohort","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/sleep-time-estimated-by-an-actigraphy-watch-correlates-with-csf-tau-34408639","doi":"10.3389/fnagi.2021.663446","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"34408639","source_url":"https://pubmed.ncbi.nlm.nih.gov/34408639/","study_design":null,"title":"Sleep Time Estimated by an Actigraphy Watch Correlates With CSF Tau in Cognitively Unimpaired Elders: The Modulatory Role of APOE","title_match":false,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/relationship-between-plasma-p-tau217-and-amyloid-pet-in-racial-and-39044491","doi":"10.14283/jpad.2024.124","journal":"The journal of prevention of Alzheimer's disease","n_participants":1018,"pmid":"39044491","source_url":"https://pubmed.ncbi.nlm.nih.gov/39044491/","study_design":null,"title":"Relationship between Plasma P-Tau217 and Amyloid PET in Racial and Ethnic Underrepresented Groups (RE-URG) Compared with Non RE-URG in LEARN and A4","title_match":false,"year":2024},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/sex-differences-in-risk-factors-that-predict-progression-from-mild-35968841","doi":"10.1017/s1355617722000297","journal":"Journal of the International Neuropsychological Society : JINS","n_participants":449,"pmid":"35968841","source_url":"https://pubmed.ncbi.nlm.nih.gov/35968841/","study_design":null,"title":"Sex differences in risk factors that predict progression from mild cognitive impairment to Alzheimer's dementia","title_match":false,"year":2023},{"alzhub_score":71,"alzhub_url":"https://alzhub.org/study/the-impact-of-exercise-on-blood-based-biomarkers-of-alzheimer-s-38488949","doi":"10.1007/s11357-024-01130-2","journal":"GeroScience","n_participants":null,"pmid":"38488949","source_url":"https://pubmed.ncbi.nlm.nih.gov/38488949/","study_design":null,"title":"The impact of exercise on blood-based biomarkers of Alzheimer's disease in cognitively unimpaired older adults","title_match":false,"year":2024},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/associations-of-plasma-phosphorylated-tau181-and-neurofilament-light-36074638","doi":"10.1111/cns.13962","journal":"CNS neuroscience & therapeutics","n_participants":234,"pmid":"36074638","source_url":"https://pubmed.ncbi.nlm.nih.gov/36074638/","study_design":null,"title":"Associations of plasma phosphorylated tau181 and neurofilament light chain with brain amyloid burden and cognition in objectively defined subtle cognitive decline patients","title_match":false,"year":2022},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/plasma-levels-of-phosphorylated-tau-181-are-associated-with-cerebral-33959711","doi":"10.1093/braincomms/fcab073","journal":"Brain communications","n_participants":389,"pmid":"33959711","source_url":"https://pubmed.ncbi.nlm.nih.gov/33959711/","study_design":"cross-sectional","title":"Plasma levels of phosphorylated tau 181 are associated with cerebral metabolic dysfunction in cognitively impaired and amyloid-positive individuals","title_match":false,"year":2021},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/inhibition-of-asparagine-endopeptidase-aep-effectively-treats-38030711","doi":"10.1038/s41386-023-01774-2","journal":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","n_participants":null,"pmid":"38030711","source_url":"https://pubmed.ncbi.nlm.nih.gov/38030711/","study_design":null,"title":"Inhibition of asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer's disease in mice","title_match":false,"year":2024},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/diagnostic-accuracy-of-plasma-p-tau217-for-detecting-pathological-39559871","doi":"10.14283/jpad.2024.152","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"39559871","source_url":"https://pubmed.ncbi.nlm.nih.gov/39559871/","study_design":"prospective cohort","title":"Diagnostic Accuracy of Plasma p-tau217 for Detecting Pathological Cerebrospinal Fluid Changes in Cognitively Unimpaired Subjects Using the Lumipulse Platform","title_match":false,"year":2024},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/subjective-cognitive-complaints-and-blood-biomarkers-of-37951931","doi":"10.1186/s13195-023-01341-3","journal":"Alzheimer's research & therapy","n_participants":6357,"pmid":"37951931","source_url":"https://pubmed.ncbi.nlm.nih.gov/37951931/","study_design":"case-control study","title":"Subjective cognitive complaints and blood biomarkers of neurodegenerative diseases: a longitudinal cohort study","title_match":false,"year":2023},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/associations-of-the-a-t-n-profiles-in-pet-csf-and-plasma-biomarkers-37506291","doi":"10.1002/alz.13413","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":100,"pmid":"37506291","source_url":"https://pubmed.ncbi.nlm.nih.gov/37506291/","study_design":null,"title":"Associations of the A/T/N profiles in PET, CSF, and plasma biomarkers with Alzheimer's disease neuropathology at autopsy","title_match":false,"year":2023},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/establishment-of-combined-diagnostic-models-of-alzheimer-s-disease-in-35710549","doi":"10.1038/s41398-022-02016-7","journal":"Translational psychiatry","n_participants":64,"pmid":"35710549","source_url":"https://pubmed.ncbi.nlm.nih.gov/35710549/","study_design":null,"title":"Establishment of combined diagnostic models of Alzheimer's disease in a Chinese cohort: the Chongqing Ageing & Dementia Study (CADS)","title_match":false,"year":2022},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/csf-a142-levels-and-glucose-metabolism-in-alzheimer-s-disease-21897007","doi":"10.3233/jad-2011-111007","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"21897007","source_url":"https://pubmed.ncbi.nlm.nih.gov/21897007/","study_design":null,"title":"CSF A\u03b2\u2081\u208b\u2084\u2082 levels and glucose metabolism in Alzheimer's disease","title_match":false,"year":2011},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/behavioral-phenotyping-of-gfap-apoe3-and-apoe4-transgenic-mice-apoe4-11476599","doi":"10.1006/exnr.2001.7715","journal":"Experimental neurology","n_participants":null,"pmid":"11476599","source_url":"https://pubmed.ncbi.nlm.nih.gov/11476599/","study_design":"longitudinal study","title":"Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology","title_match":true,"year":2001},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/the-coarse-grained-plaque-a-divergent-a-plaque-type-in-early-onset-32926214","doi":"10.1007/s00401-020-02198-8","journal":"Acta neuropathologica","n_participants":74,"pmid":"32926214","source_url":"https://pubmed.ncbi.nlm.nih.gov/32926214/","study_design":null,"title":"The coarse-grained plaque: a divergent A\u03b2 plaque-type in early-onset Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/is-there-chronic-brain-damage-in-retired-nfl-players-neuroradiology-25177413","doi":"10.1177/1941738114540270","journal":"Sports health","n_participants":null,"pmid":"25177413","source_url":"https://pubmed.ncbi.nlm.nih.gov/25177413/","study_design":null,"title":"Is There Chronic Brain Damage in Retired NFL Players? Neuroradiology, Neuropsychology, and Neurology Examinations of 45 Retired Players","title_match":false,"year":2014},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-reduction-with-antisense-oligonucleotides-decreases-33550655","doi":"10.1002/ana.26043","journal":"Annals of neurology","n_participants":null,"pmid":"33550655","source_url":"https://pubmed.ncbi.nlm.nih.gov/33550655/","study_design":null,"title":"Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model","title_match":true,"year":2021},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/the-dynamics-of-biomarkers-across-the-clinical-spectrum-of-alzheimer-32534594","doi":"10.1186/s13195-020-00636-z","journal":"Alzheimer's research & therapy","n_participants":2014,"pmid":"32534594","source_url":"https://pubmed.ncbi.nlm.nih.gov/32534594/","study_design":"longitudinal study","title":"The dynamics of biomarkers across the clinical spectrum of Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe-4-specific-imbalance-of-arachidonic-acid-and-docosahexaenoic-28333036","doi":"10.18632/aging.101203","journal":"Aging","n_participants":null,"pmid":"28333036","source_url":"https://pubmed.ncbi.nlm.nih.gov/28333036/","study_design":null,"title":"APOE \u03b54 specific imbalance of arachidonic acid and docosahexaenoic acid in serum phospholipids identifies individuals with preclinical Mild Cognitive Impairment/Alzheimer's Disease","title_match":true,"year":2017},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/prospective-biomarkers-of-alzheimer-s-disease-a-systematic-review-and-35905816","doi":"10.1016/j.arr.2022.101699","journal":"Ageing research reviews","n_participants":70,"pmid":"35905816","source_url":"https://pubmed.ncbi.nlm.nih.gov/35905816/","study_design":"meta-analysis","title":"Prospective biomarkers of Alzheimer's disease: A systematic review and meta-analysis","title_match":false,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/performance-of-the-plasma-a42-a40-ratio-measured-with-a-novel-hplc-ms-34686209","doi":"10.1186/s13195-021-00911-7","journal":"Alzheimer's research & therapy","n_participants":134,"pmid":"34686209","source_url":"https://pubmed.ncbi.nlm.nih.gov/34686209/","study_design":null,"title":"Performance of the plasma A\u03b242/A\u03b240 ratio, measured with a novel HPLC-MS/MS method, as a biomarker of amyloid PET status in a DPUK-KOREAN cohort","title_match":false,"year":2021},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/the-contribution-of-vascular-risk-factors-in-neurodegenerative-32753051","doi":"10.1186/s13195-020-00658-7","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"32753051","source_url":"https://pubmed.ncbi.nlm.nih.gov/32753051/","study_design":"cross-sectional","title":"The contribution of vascular risk factors in neurodegenerative disorders: from mild cognitive impairment to Alzheimer's disease","title_match":false,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/neuronal-or-glial-expression-of-human-apolipoprotein-e4-affects-16400027","doi":"10.2353/ajpath.2006.050752","journal":"The American journal of pathology","n_participants":null,"pmid":"16400027","source_url":"https://pubmed.ncbi.nlm.nih.gov/16400027/","study_design":null,"title":"Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice","title_match":true,"year":2006},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/plasma-beta-amyloid-level-and-depression-in-older-adults-22499763","doi":"10.1093/gerona/gls093","journal":"The journals of gerontology. Series A, Biological sciences and medical sciences","n_participants":null,"pmid":"22499763","source_url":"https://pubmed.ncbi.nlm.nih.gov/22499763/","study_design":"longitudinal study","title":"Plasma beta amyloid level and depression in older adults","title_match":false,"year":2013},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/plasma-biomarkers-of-alzheimer-s-disease-and-neurodegeneration-39350363","doi":"10.14283/jpad.2024.142","journal":"The journal of prevention of Alzheimer's disease","n_participants":null,"pmid":"39350363","source_url":"https://pubmed.ncbi.nlm.nih.gov/39350363/","study_design":null,"title":"Plasma Biomarkers of Alzheimer's Disease and Neurodegeneration According to Sociodemographic Characteristics and Chronic Health Conditions","title_match":false,"year":2024},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/sorl1-gene-plasma-biomarkers-and-the-risk-of-alzheimer-s-disease-for-28034305","doi":"10.1186/s13195-016-0222-x","journal":"Alzheimer's research & therapy","n_participants":798,"pmid":"28034305","source_url":"https://pubmed.ncbi.nlm.nih.gov/28034305/","study_design":null,"title":"SORL1 gene, plasma biomarkers, and the risk of Alzheimer's disease for the Han Chinese population in Taiwan","title_match":false,"year":2016},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/candidate-genes-for-alzheimer-s-disease-are-associated-with-26166206","doi":"10.1016/j.neurobiolaging.2015.06.020","journal":"Neurobiology of aging","n_participants":null,"pmid":"26166206","source_url":"https://pubmed.ncbi.nlm.nih.gov/26166206/","study_design":null,"title":"Candidate genes for Alzheimer's disease are associated with individual differences in plasma levels of beta amyloid peptides in adults with Down syndrome","title_match":false,"year":2015},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/the-demographic-and-medical-correlates-of-plasma-a40-and-a42-22732677","doi":"10.1097/wad.0b013e318260a8cb","journal":"Alzheimer disease and associated disorders","n_participants":null,"pmid":"22732677","source_url":"https://pubmed.ncbi.nlm.nih.gov/22732677/","study_design":"cross-sectional","title":"The demographic and medical correlates of plasma a\u03b240 and a\u03b242","title_match":false,"year":2013},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/plasma-a42-as-a-biomarker-of-prodromal-alzheimer-s-disease-30149449","doi":"10.3233/jad-180321","journal":"Journal of Alzheimer's disease : JAD","n_participants":76,"pmid":"30149449","source_url":"https://pubmed.ncbi.nlm.nih.gov/30149449/","study_design":"longitudinal study","title":"Plasma A\u03b242 as a Biomarker of Prodromal Alzheimer's Disease Progression in Patients with Amnestic Mild Cognitive Impairment: Evidence from the PharmaCog/E-ADNI Study","title_match":false,"year":2019},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/menopausal-hormone-therapy-is-associated-with-worse-levels-of-39783876","doi":"10.1002/alz.14456","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"39783876","source_url":"https://pubmed.ncbi.nlm.nih.gov/39783876/","study_design":null,"title":"Menopausal hormone therapy is associated with worse levels of Alzheimer's disease biomarkers in APOE \u03b54-carrying women: An observational study","title_match":true,"year":2025},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/association-of-plasma-a-sub-42-sub-a-sub-40-sub-ratio-and-late-onset-37541842","doi":"10.1212/wnl.0000000000207635","journal":"Neurology","n_participants":null,"pmid":"37541842","source_url":"https://pubmed.ncbi.nlm.nih.gov/37541842/","study_design":null,"title":"Association of Plasma A\u03b242/A\u03b240 Ratio and Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study","title_match":false,"year":2023},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/midlife-occupational-cognitive-requirements-protect-cognitive-36571008","doi":"10.3389/fpsyg.2022.957308","journal":"Frontiers in psychology","n_participants":2369,"pmid":"36571008","source_url":"https://pubmed.ncbi.nlm.nih.gov/36571008/","study_design":"cross-sectional","title":"Midlife occupational cognitive requirements protect cognitive function in old age by increasing cognitive reserve","title_match":false,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/apoe-4-modulates-the-association-among-plasma-a-lt-sub-gt-42-lt-sub-35351867","doi":"10.1038/s41398-022-01899-w","journal":"Translational psychiatry","n_participants":null,"pmid":"35351867","source_url":"https://pubmed.ncbi.nlm.nih.gov/35351867/","study_design":"longitudinal study","title":"APOE-\u03b54 modulates the association among plasma A\u03b242/A\u03b240, vascular diseases, neurodegeneration and cognitive decline in non-demented elderly adults","title_match":true,"year":2022},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/fatty-acid-binding-protein-3-fabp3-and-apolipoprotein-e4-apoe4-as-34300173","doi":"10.3390/jcm10143009","journal":"Journal of clinical medicine","n_participants":70,"pmid":"34300173","source_url":"https://pubmed.ncbi.nlm.nih.gov/34300173/","study_design":null,"title":"Fatty Acid Binding Protein 3 (FABP3) and Apolipoprotein E4 (ApoE4) as Lipid Metabolism-Related Biomarkers of Alzheimer's Disease","title_match":true,"year":2021},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/age-sex-and-apoe-4-modify-the-balance-between-soluble-and-fibrillar-35236958","doi":"10.1038/s41380-022-01436-7","journal":"Molecular psychiatry","n_participants":320,"pmid":"35236958","source_url":"https://pubmed.ncbi.nlm.nih.gov/35236958/","study_design":null,"title":"Age, sex and APOE-\u03b54 modify the balance between soluble and fibrillar \u03b2-amyloid in non-demented individuals: topographical patterns across two independent cohorts","title_match":true,"year":2022},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/presenilin-is-essential-for-apoe-secretion-a-novel-role-of-presenilin-34987110","doi":"10.1523/jneurosci.2039-21.2021","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"34987110","source_url":"https://pubmed.ncbi.nlm.nih.gov/34987110/","study_design":null,"title":"Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis","title_match":false,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/erlangen-score-as-a-tool-to-predict-progression-from-mild-cognitive-30611311","doi":"10.1186/s13195-018-0456-x","journal":"Alzheimer's research & therapy","n_participants":47,"pmid":"30611311","source_url":"https://pubmed.ncbi.nlm.nih.gov/30611311/","study_design":null,"title":"Erlangen Score as a tool to predict progression from mild cognitive impairment to dementia in Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":78,"alzhub_url":"https://alzhub.org/study/whole-exome-sequence-based-association-analyses-of-plasma-amyloid-in-28704393","doi":"10.1371/journal.pone.0180046","journal":"PloS one","n_participants":725,"pmid":"28704393","source_url":"https://pubmed.ncbi.nlm.nih.gov/28704393/","study_design":"meta-analysis","title":"Whole exome sequence-based association analyses of plasma amyloid-\u03b2 in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/impact-of-cerebrospinal-fluid-matrix-on-the-detection-of-alzheimer-s-26332787","doi":"10.1111/jnc.13297","journal":"Journal of neurochemistry","n_participants":null,"pmid":"26332787","source_url":"https://pubmed.ncbi.nlm.nih.gov/26332787/","study_design":null,"title":"Impact of cerebrospinal fluid matrix on the detection of Alzheimer's disease with A\u03b242 and influence of disease on the total-A\u03b242/A\u03b240 ratio","title_match":false,"year":2015},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/serum-ngal-is-associated-with-distinct-plasma-amyloid-peptides-25613101","doi":"10.3233/jad-142514","journal":"Journal of Alzheimer's disease : JAD","n_participants":67,"pmid":"25613101","source_url":"https://pubmed.ncbi.nlm.nih.gov/25613101/","study_design":null,"title":"Serum NGAL is Associated with Distinct Plasma Amyloid-\u03b2 Peptides According to the Clinical Diagnosis of Dementia in Down Syndrome","title_match":false,"year":2015},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/combination-of-plasma-tumor-necrosis-factor-receptors-signaling-23500026","doi":"10.1016/j.neulet.2013.03.007","journal":"Neuroscience letters","n_participants":153,"pmid":"23500026","source_url":"https://pubmed.ncbi.nlm.nih.gov/23500026/","study_design":null,"title":"Combination of plasma tumor necrosis factor receptors signaling proteins, beta-amyloid and apolipoprotein E for the detection of Alzheimer's disease","title_match":false,"year":2013},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/comparison-of-plasma-soluble-and-extracellular-vesicles-associated-38943196","doi":"10.1186/s13195-024-01508-6","journal":"Alzheimer's research & therapy","n_participants":168,"pmid":"38943196","source_url":"https://pubmed.ncbi.nlm.nih.gov/38943196/","study_design":null,"title":"Comparison of plasma soluble and extracellular vesicles-associated biomarkers in Alzheimer's disease patients and cognitively normal individuals","title_match":false,"year":2024},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/alzheimer-s-polygenic-risk-scores-are-associated-with-cognitive-37855447","doi":"10.1002/alz.13506","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"37855447","source_url":"https://pubmed.ncbi.nlm.nih.gov/37855447/","study_design":null,"title":"Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome","title_match":false,"year":2024},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/association-between-life-s-simple-7-and-cerebrospinal-fluid-35619174","doi":"10.1186/s13195-022-01019-2","journal":"Alzheimer's research & therapy","n_participants":null,"pmid":"35619174","source_url":"https://pubmed.ncbi.nlm.nih.gov/35619174/","study_design":null,"title":"Association between Life's Simple 7 and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: the CABLE study","title_match":false,"year":2022},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/associations-of-risk-genes-with-onset-age-and-plasma-biomarkers-of-35001095","doi":"10.1038/s41386-021-01258-1","journal":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","n_participants":3604,"pmid":"35001095","source_url":"https://pubmed.ncbi.nlm.nih.gov/35001095/","study_design":null,"title":"Associations of risk genes with onset age and plasma biomarkers of Alzheimer's disease: a large case-control study in mainland China","title_match":false,"year":2022},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/lysophosphatidylcholines-are-associated-with-amyloidosis-in-early-41407938","doi":"10.1038/s43587-025-01025-7","journal":"Nature aging","n_participants":1068,"pmid":"41407938","source_url":"https://pubmed.ncbi.nlm.nih.gov/41407938/","study_design":null,"title":"Lysophosphatidylcholines are associated with amyloidosis in early stages of Alzheimer's disease","title_match":false,"year":2026},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/anxiety-correlates-with-cortical-surface-area-in-subjective-cognitive-31159873","doi":"10.1186/s13195-019-0505-0","journal":"Alzheimer's research & therapy","n_participants":65,"pmid":"31159873","source_url":"https://pubmed.ncbi.nlm.nih.gov/31159873/","study_design":null,"title":"Anxiety correlates with cortical surface area in subjective cognitive decline: APOE \u03b54 carriers versus APOE \u03b54 non-carriers","title_match":true,"year":2019},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/plasma-apolipoprotein-j-as-a-potential-biomarker-for-alzheimer-s-27239546","doi":"10.1016/j.dadm.2015.12.001","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":833,"pmid":"27239546","source_url":"https://pubmed.ncbi.nlm.nih.gov/27239546/","study_design":null,"title":"Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging","title_match":false,"year":2016},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/apoe-4-gene-dose-effect-on-imaging-and-blood-biomarkers-of-37016464","doi":"10.1186/s13195-023-01209-6","journal":"Alzheimer's research & therapy","n_participants":19,"pmid":"37016464","source_url":"https://pubmed.ncbi.nlm.nih.gov/37016464/","study_design":null,"title":"APOE \u03b54 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly","title_match":true,"year":2023},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/a-blood-based-biomarker-panel-indicates-il-10-and-il-12-23p40-are-29070909","doi":"10.1038/s41598-017-14020-9","journal":"Scientific reports","n_participants":null,"pmid":"29070909","source_url":"https://pubmed.ncbi.nlm.nih.gov/29070909/","study_design":null,"title":"A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of \u03b2-amyloid load in an AD cohort","title_match":false,"year":2017},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-beta-oligomer-is-related-to-subjective-cognitive-36324157","doi":"10.1186/s13195-022-01104-6","journal":"Alzheimer's research & therapy","n_participants":126,"pmid":"36324157","source_url":"https://pubmed.ncbi.nlm.nih.gov/36324157/","study_design":"cross-sectional","title":"Plasma amyloid-beta oligomer is related to subjective cognitive decline and brain amyloid status","title_match":false,"year":2022},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/a-conformation-variant-of-p53-combined-with-machine-learning-33375220","doi":"10.3390/jpm11010014","journal":"Journal of personalized medicine","n_participants":null,"pmid":"33375220","source_url":"https://pubmed.ncbi.nlm.nih.gov/33375220/","study_design":"longitudinal study","title":"A Conformation Variant of p53 Combined with Machine Learning Identifies Alzheimer Disease in Preclinical and Prodromal Stages","title_match":false,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/gender-related-increase-of-tropomyosin-1-abundance-in-platelets-of-29278785","doi":"10.1016/j.jprot.2017.12.018","journal":"Journal of proteomics","n_participants":null,"pmid":"29278785","source_url":"https://pubmed.ncbi.nlm.nih.gov/29278785/","study_design":null,"title":"Gender-related increase of tropomyosin-1 abundance in platelets of Alzheimer's disease and mild cognitive impairment patients","title_match":false,"year":2018},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/blood-biomarkers-of-neurodegeneration-associate-differently-with-38762725","doi":"10.1186/s13195-024-01477-w","journal":"Alzheimer's research & therapy","n_participants":19,"pmid":"38762725","source_url":"https://pubmed.ncbi.nlm.nih.gov/38762725/","study_design":null,"title":"Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE \u03b54-enriched cognitively unimpaired elderly","title_match":true,"year":2024},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/a-conformational-variant-of-p53-u-p53az-as-blood-based-biomarker-for-35841248","doi":"10.14283/jpad.2022.52","journal":"The journal of prevention of Alzheimer's disease","n_participants":482,"pmid":"35841248","source_url":"https://pubmed.ncbi.nlm.nih.gov/35841248/","study_design":"longitudinal study","title":"A Conformational Variant of p53 (U-p53AZ) as Blood-Based Biomarker for the Prediction of the Onset of Symptomatic Alzheimer's Disease","title_match":false,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/cell-free-dna-as-peripheral-biomarker-of-alzheimer-s-disease-38607732","doi":"10.14336/ad.2024.0329","journal":"Aging and disease","n_participants":null,"pmid":"38607732","source_url":"https://pubmed.ncbi.nlm.nih.gov/38607732/","study_design":null,"title":"Cell-Free DNA As Peripheral Biomarker of Alzheimer's Disease","title_match":false,"year":2024},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/retinal-microvascular-alterations-in-alzheimer-s-disease-linking-41065118","doi":"10.1002/alz.70745","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":72,"pmid":"41065118","source_url":"https://pubmed.ncbi.nlm.nih.gov/41065118/","study_design":"cross-sectional","title":"Retinal microvascular alterations in Alzheimer's disease: Linking blood plasma biomarkers and cerebral small vessel pathology","title_match":false,"year":2025},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/longitudinal-trajectory-of-plasma-p-tau217-in-cognitively-unimpaired-39702464","doi":"10.1186/s13195-024-01642-1","journal":"Alzheimer's research & therapy","n_participants":151,"pmid":"39702464","source_url":"https://pubmed.ncbi.nlm.nih.gov/39702464/","study_design":"longitudinal study","title":"Longitudinal trajectory of plasma p-tau217 in cognitively unimpaired subjects","title_match":false,"year":2024},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/multivariate-analyses-of-peripheral-blood-leukocyte-transcripts-28716532","doi":"10.1016/j.neurobiolaging.2017.05.012","journal":"Neurobiology of aging","n_participants":null,"pmid":"28716532","source_url":"https://pubmed.ncbi.nlm.nih.gov/28716532/","study_design":null,"title":"Multivariate analyses of peripheral blood leukocyte transcripts distinguish Alzheimer's, Parkinson's, control, and those at risk for developing Alzheimer's","title_match":false,"year":2017},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/association-of-plasma-biomarkers-with-cognitive-function-in-persons-37954546","doi":"10.1002/dad2.12496","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"37954546","source_url":"https://pubmed.ncbi.nlm.nih.gov/37954546/","study_design":null,"title":"Association of plasma biomarkers with cognitive function in persons with dementia and cognitively healthy in the Democratic Republic of Congo","title_match":false,"year":2023},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/asic-e4-interplay-of-beta-amyloid-synaptic-density-and-35222254","doi":"10.3389/fneur.2022.826423","journal":"Frontiers in neurology","n_participants":19,"pmid":"35222254","source_url":"https://pubmed.ncbi.nlm.nih.gov/35222254/","study_design":null,"title":"ASIC-E4: Interplay of Beta-Amyloid, Synaptic Density and Neuroinflammation in Cognitively Normal Volunteers With Three Levels of Genetic Risk for Late-Onset Alzheimer's Disease - Study Protocol and Baseline Characteristics","title_match":false,"year":2022},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/potential-utility-of-soluble-p3-alcadein-plasma-levels-as-a-biomarker-22571980","doi":"10.3233/jad-2012-120601","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"22571980","source_url":"https://pubmed.ncbi.nlm.nih.gov/22571980/","study_design":null,"title":"Potential utility of soluble p3-alcadein \u03b1 plasma levels as a biomarker for sporadic Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":60,"alzhub_url":"https://alzhub.org/study/physical-function-is-associated-with-cognitive-status-brain-amyloid-39155519","doi":"10.1111/cns.14921","journal":"CNS neuroscience & therapeutics","n_participants":4189,"pmid":"39155519","source_url":"https://pubmed.ncbi.nlm.nih.gov/39155519/","study_design":null,"title":"Physical function is associated with cognitive status, brain amyloid-beta deposition, and blood biomarkers in Chinese Han population","title_match":false,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/plasma-amyloid-42-40-and-apolipoprotein-e-for-amyloid-pet-pre-36926368","doi":"10.1093/braincomms/fcad015","journal":"Brain communications","n_participants":null,"pmid":"36926368","source_url":"https://pubmed.ncbi.nlm.nih.gov/36926368/","study_design":null,"title":"Plasma amyloid-\u03b242/40 and apolipoprotein E for amyloid PET pre-screening in secondary prevention trials of Alzheimer's disease","title_match":false,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/clinical-utility-of-an-antibody-free-lc-ms-method-to-detect-brain-37274930","doi":"10.1002/dad2.12451","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":null,"pmid":"37274930","source_url":"https://pubmed.ncbi.nlm.nih.gov/37274930/","study_design":null,"title":"Clinical utility of an antibody-free LC-MS method to detect brain amyloid deposition in cognitively unimpaired individuals from the screening visit of the A4 Study","title_match":false,"year":2023},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/parkinson-s-progression-markers-initiative-brain-autopsy-program-35803091","doi":"10.1016/j.parkreldis.2022.06.017","journal":"Parkinsonism & related disorders","n_participants":15,"pmid":"35803091","source_url":"https://pubmed.ncbi.nlm.nih.gov/35803091/","study_design":"longitudinal study","title":"Parkinson's Progression Markers Initiative brain autopsy program","title_match":false,"year":2022},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/analysis-of-plasma-proteins-using-2d-gels-and-novel-fluorescent-35081972","doi":"10.1186/s12953-021-00185-9","journal":"Proteome science","n_participants":null,"pmid":"35081972","source_url":"https://pubmed.ncbi.nlm.nih.gov/35081972/","study_design":null,"title":"Analysis of plasma proteins using 2D gels and novel fluorescent probes: in search of blood based biomarkers for Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/dysregulated-calcium-signaling-in-the-aged-primate-association-40735190","doi":"10.3389/fnagi.2025.1610350","journal":"Frontiers in aging neuroscience","n_participants":null,"pmid":"40735190","source_url":"https://pubmed.ncbi.nlm.nih.gov/40735190/","study_design":null,"title":"Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer's disease neuropathology","title_match":false,"year":2025},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe-and-alzheimer-s-disease-from-lipid-transport-to-physiopathology-33679311","doi":"10.3389/fnins.2021.630502","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"33679311","source_url":"https://pubmed.ncbi.nlm.nih.gov/33679311/","study_design":null,"title":"APOE and Alzheimer's Disease: From Lipid Transport to Physiopathology and Therapeutics","title_match":false,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alzheimer-s-prevention-initiative-a-plan-to-accelerate-the-evaluation-21971471","doi":"10.3233/jad-2011-0059","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"21971471","source_url":"https://pubmed.ncbi.nlm.nih.gov/21971471/","study_design":null,"title":"Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments","title_match":false,"year":2011},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/increased-8-12-iso-ipf2alpha-vi-in-alzheimer-s-disease-correlation-of-11079549","doi":"10.1002/1531-8249(200011)48:5<809::aid-ana19>3.0.co;2-9","journal":"Annals of neurology","n_participants":null,"pmid":"11079549","source_url":"https://pubmed.ncbi.nlm.nih.gov/11079549/","study_design":null,"title":"Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity","title_match":false,"year":2000},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/consensus-report-of-the-working-group-on-molecular-and-biochemical-9558143","doi":null,"journal":"Neurobiology of aging","n_participants":null,"pmid":"9558143","source_url":"https://pubmed.ncbi.nlm.nih.gov/9558143/","study_design":null,"title":"Consensus report of the Working Group on: \"Molecular and Biochemical Markers of Alzheimer's Disease\". The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group","title_match":false,"year":1998},{"alzhub_score":80,"alzhub_url":"https://alzhub.org/study/bapineuzumab-for-mild-to-moderate-alzheimer-s-disease-in-two-global-27176461","doi":"10.1186/s13195-016-0189-7","journal":"Alzheimer's research & therapy","n_participants":329,"pmid":"27176461","source_url":"https://pubmed.ncbi.nlm.nih.gov/27176461/","study_design":"clinical trial","title":"Bapineuzumab for mild to moderate Alzheimer's disease in two global, randomized, phase 3 trials","title_match":false,"year":2016},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/stable-expression-and-secretion-of-apolipoproteins-e3-and-e4-in-mouse-7592957","doi":"10.1074/jbc.270.45.27063","journal":"The Journal of biological chemistry","n_participants":null,"pmid":"7592957","source_url":"https://pubmed.ncbi.nlm.nih.gov/7592957/","study_design":null,"title":"Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth","title_match":false,"year":1995},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/value-of-csf-beta-amyloid1-42-and-tau-as-predictors-of-alzheimer-s-14699432","doi":"10.1038/sj.mp.4001473","journal":"Molecular psychiatry","n_participants":52,"pmid":"14699432","source_url":"https://pubmed.ncbi.nlm.nih.gov/14699432/","study_design":null,"title":"Value of CSF beta-amyloid1-42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment","title_match":false,"year":2004},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/exercise-engagement-as-a-moderator-of-the-effects-of-apoe-genotype-on-22232206","doi":"10.1001/archneurol.2011.845","journal":"Archives of neurology","n_participants":165,"pmid":"22232206","source_url":"https://pubmed.ncbi.nlm.nih.gov/22232206/","study_design":null,"title":"Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition","title_match":false,"year":2012},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/obstructive-sleep-apnea-severity-affects-amyloid-burden-in-29125327","doi":"10.1164/rccm.201704-0704oc","journal":"American journal of respiratory and critical care medicine","n_participants":null,"pmid":"29125327","source_url":"https://pubmed.ncbi.nlm.nih.gov/29125327/","study_design":"longitudinal study","title":"Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly. A Longitudinal Study","title_match":false,"year":2018},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amyloid-beta-peptide-ratio-42-40-but-not-a-beta-42-correlates-with-17254013","doi":"10.1111/j.1471-4159.2006.04404.x","journal":"Journal of neurochemistry","n_participants":null,"pmid":"17254013","source_url":"https://pubmed.ncbi.nlm.nih.gov/17254013/","study_design":null,"title":"Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load","title_match":false,"year":2007},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/hypometabolism-and-altered-cerebrospinal-fluid-markers-in-normal-17720148","doi":"10.1016/j.biopsych.2007.05.030","journal":"Biological psychiatry","n_participants":null,"pmid":"17720148","source_url":"https://pubmed.ncbi.nlm.nih.gov/17720148/","study_design":"longitudinal study","title":"Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaints","title_match":true,"year":2008},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/sex-differences-in-the-association-between-tau-pet-and-cognitive-37641484","doi":"10.1002/alz.13432","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":343,"pmid":"37641484","source_url":"https://pubmed.ncbi.nlm.nih.gov/37641484/","study_design":null,"title":"Sex differences in the association between tau PET and cognitive performance in a non-Hispanic White cohort with preclinical AD","title_match":false,"year":2024},{"alzhub_score":79,"alzhub_url":"https://alzhub.org/study/impact-of-short-term-computerized-cognitive-training-on-cognition-in-38642588","doi":"10.1016/j.jamda.2024.03.008","journal":"Journal of the American Medical Directors Association","n_participants":6544,"pmid":"38642588","source_url":"https://pubmed.ncbi.nlm.nih.gov/38642588/","study_design":"randomized controlled trial","title":"Impact of Short-Term Computerized Cognitive Training on Cognition in Older Adults With and Without Genetic Risk of Alzheimer's Disease: Outcomes From the START Randomized Controlled Trial","title_match":false,"year":2024},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/the-preventing-alzheimer-s-with-cognitive-training-pact-randomized-36341846","doi":"10.1016/j.cct.2022.106978","journal":"Contemporary clinical trials","n_participants":null,"pmid":"36341846","source_url":"https://pubmed.ncbi.nlm.nih.gov/36341846/","study_design":null,"title":"The Preventing Alzheimer's with Cognitive Training (PACT) randomized clinical trial","title_match":false,"year":2022},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/driving-into-diagnosis-leveraging-high-resolution-telematics-and-41393339","doi":"10.1177/25424823251407543","journal":"Journal of Alzheimer's disease reports","n_participants":254,"pmid":"41393339","source_url":"https://pubmed.ncbi.nlm.nih.gov/41393339/","study_design":null,"title":"Driving into diagnosis: Leveraging high-resolution telematics and sensorimotor profiling to identify preclinical Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/recent-advances-in-the-detection-and-management-of-motor-dysfunction-40400272","doi":"10.22365/jpsych.2025.012","journal":"Psychiatrike = Psychiatriki","n_participants":null,"pmid":"40400272","source_url":"https://pubmed.ncbi.nlm.nih.gov/40400272/","study_design":"longitudinal study","title":"Recent advances in the detection and management of motor dysfunction in Alzheimer's disease","title_match":false,"year":2025},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/development-and-validation-of-cognitive-ageing-risk-score-cars-for-38515012","doi":"10.1186/s12877-024-04879-5","journal":"BMC geriatrics","n_participants":null,"pmid":"38515012","source_url":"https://pubmed.ncbi.nlm.nih.gov/38515012/","study_design":null,"title":"Development and validation of cognitive ageing risk score (CARS) for early detection of subtle cognitive deficits in older people","title_match":false,"year":2024},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/intensive-assessment-of-executive-functions-derived-from-performance-37260752","doi":"10.1016/j.isci.2023.106886","journal":"iScience","n_participants":56,"pmid":"37260752","source_url":"https://pubmed.ncbi.nlm.nih.gov/37260752/","study_design":null,"title":"Intensive assessment of executive functions derived from performance in cognitive training games","title_match":false,"year":2023},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apoe-genotype-accounts-for-the-vast-majority-of-ad-risk-and-ad-15172743","doi":"10.1016/j.neurobiolaging.2003.12.023","journal":"Neurobiology of aging","n_participants":null,"pmid":"15172743","source_url":"https://pubmed.ncbi.nlm.nih.gov/15172743/","study_design":null,"title":"ApoE genotype accounts for the vast majority of AD risk and AD pathology","title_match":false,"year":2004},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/evidence-for-human-transmission-of-amyloid-pathology-and-cerebral-26354483","doi":"10.1038/nature15369","journal":"Nature","n_participants":116,"pmid":"26354483","source_url":"https://pubmed.ncbi.nlm.nih.gov/26354483/","study_design":"cohort study","title":"Evidence for human transmission of amyloid-\u03b2 pathology and cerebral amyloid angiopathy","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/insulin-insulin-degrading-enzyme-and-amyloid-beta-peptide-in-16399206","doi":"10.1016/j.neurobiolaging.2005.01.004","journal":"Neurobiology of aging","n_participants":null,"pmid":"16399206","source_url":"https://pubmed.ncbi.nlm.nih.gov/16399206/","study_design":null,"title":"Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis","title_match":false,"year":2006},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/microvascular-injury-and-blood-brain-barrier-leakage-in-alzheimer-s-16782234","doi":"10.1016/j.neurobiolaging.2006.05.016","journal":"Neurobiology of aging","n_participants":null,"pmid":"16782234","source_url":"https://pubmed.ncbi.nlm.nih.gov/16782234/","study_design":null,"title":"Microvascular injury and blood-brain barrier leakage in Alzheimer's disease","title_match":false,"year":2007},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/apoe4-impairs-neuron-astrocyte-coupling-of-fatty-acid-metabolism-33406436","doi":"10.1016/j.celrep.2020.108572","journal":"Cell reports","n_participants":null,"pmid":"33406436","source_url":"https://pubmed.ncbi.nlm.nih.gov/33406436/","study_design":null,"title":"ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism","title_match":true,"year":2021},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/gain-of-toxic-apolipoprotein-e4-effects-in-human-ipsc-derived-neurons-29632371","doi":"10.1038/s41591-018-0004-z","journal":"Nature medicine","n_participants":null,"pmid":"29632371","source_url":"https://pubmed.ncbi.nlm.nih.gov/29632371/","study_design":null,"title":"Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector","title_match":true,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/apoe4-an-emerging-therapeutic-target-for-alzheimer-s-disease-30890171","doi":"10.1186/s12916-019-1299-4","journal":"BMC medicine","n_participants":null,"pmid":"30890171","source_url":"https://pubmed.ncbi.nlm.nih.gov/30890171/","study_design":null,"title":"ApoE4: an emerging therapeutic target for Alzheimer's disease","title_match":true,"year":2019},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/amyloid-precursor-protein-and-endosomal-lysosomal-dysfunction-in-28663518","doi":"10.1096/fj.201700359","journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","n_participants":null,"pmid":"28663518","source_url":"https://pubmed.ncbi.nlm.nih.gov/28663518/","study_design":null,"title":"Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/gab2-alleles-modify-alzheimer-s-risk-in-apoe-epsilon4-carriers-17553421","doi":"10.1016/j.neuron.2007.05.022","journal":"Neuron","n_participants":null,"pmid":"17553421","source_url":"https://pubmed.ncbi.nlm.nih.gov/17553421/","study_design":null,"title":"GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers","title_match":true,"year":2007},{"alzhub_score":64,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-and-cognitive-performance-a-meta-analysis-15584785","doi":"10.1037/0882-7974.19.4.592","journal":"Psychology and aging","n_participants":null,"pmid":"15584785","source_url":"https://pubmed.ncbi.nlm.nih.gov/15584785/","study_design":"meta-analysis","title":"Apolipoprotein E and cognitive performance: a meta-analysis","title_match":false,"year":2004},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/confidence-intervals-for-predictive-values-with-an-emphasis-to-case-16927452","doi":"10.1002/sim.2677","journal":"Statistics in medicine","n_participants":null,"pmid":"16927452","source_url":"https://pubmed.ncbi.nlm.nih.gov/16927452/","study_design":"case-control study","title":"Confidence intervals for predictive values with an emphasis to case-control studies","title_match":false,"year":2007},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/acceleration-of-alzheimer-s-fibril-formation-by-apolipoprotein-e-in-7977635","doi":null,"journal":"The American journal of pathology","n_participants":null,"pmid":"7977635","source_url":"https://pubmed.ncbi.nlm.nih.gov/7977635/","study_design":null,"title":"Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro","title_match":false,"year":1994},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apoe4-reduces-glutamate-receptor-function-and-synaptic-plasticity-by-20547867","doi":"10.1073/pnas.0914984107","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"20547867","source_url":"https://pubmed.ncbi.nlm.nih.gov/20547867/","study_design":null,"title":"ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling","title_match":true,"year":2010},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-receptors-and-modulation-of-alzheimer-s-disease-28434655","doi":"10.1016/j.biopsych.2017.03.003","journal":"Biological psychiatry","n_participants":null,"pmid":"28434655","source_url":"https://pubmed.ncbi.nlm.nih.gov/28434655/","study_design":null,"title":"Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease","title_match":false,"year":2018},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/lt-i-gt-apoe4-lt-i-gt-disrupts-intracellular-lipid-homeostasis-in-33658354","doi":"10.1126/scitranslmed.aaz4564","journal":"Science translational medicine","n_participants":null,"pmid":"33658354","source_url":"https://pubmed.ncbi.nlm.nih.gov/33658354/","study_design":null,"title":"APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia","title_match":true,"year":2021},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/synaptic-basis-of-alzheimer-s-disease-focus-on-synaptic-amyloid-beta-33157321","doi":"10.1016/j.arr.2020.101208","journal":"Ageing research reviews","n_participants":null,"pmid":"33157321","source_url":"https://pubmed.ncbi.nlm.nih.gov/33157321/","study_design":null,"title":"Synaptic basis of Alzheimer's disease: Focus on synaptic amyloid beta, P-tau and mitochondria","title_match":false,"year":2021},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-fragments-present-in-alzheimer-s-disease-brains-11447277","doi":"10.1073/pnas.151254698","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"11447277","source_url":"https://pubmed.ncbi.nlm.nih.gov/11447277/","study_design":null,"title":"Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons","title_match":false,"year":2001},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/lipid-accumulation-induced-by-apoe4-impairs-microglial-surveillance-35931030","doi":"10.1016/j.stem.2022.07.005","journal":"Cell stem cell","n_participants":null,"pmid":"35931030","source_url":"https://pubmed.ncbi.nlm.nih.gov/35931030/","study_design":null,"title":"Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity","title_match":true,"year":2022},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/isoform-specific-effects-of-human-apolipoprotein-e-on-brain-function-9724804","doi":"10.1073/pnas.95.18.10914","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"9724804","source_url":"https://pubmed.ncbi.nlm.nih.gov/9724804/","study_design":null,"title":"Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females","title_match":false,"year":1998},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-associates-with-beta-amyloid-peptide-of-alzheimer-s-8040342","doi":"10.1172/jci117407","journal":"The Journal of clinical investigation","n_participants":null,"pmid":"8040342","source_url":"https://pubmed.ncbi.nlm.nih.gov/8040342/","study_design":null,"title":"Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3","title_match":true,"year":1994},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/reduced-grid-cell-like-representations-in-adults-at-genetic-risk-for-26494756","doi":"10.1126/science.aac8128","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"26494756","source_url":"https://pubmed.ncbi.nlm.nih.gov/26494756/","study_design":null,"title":"Reduced grid-cell-like representations in adults at genetic risk for Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-causes-age-and-tau-dependent-impairment-of-20943911","doi":"10.1523/jneurosci.4040-10.2010","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"20943911","source_url":"https://pubmed.ncbi.nlm.nih.gov/20943911/","study_design":null,"title":"Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice","title_match":true,"year":2010},{"alzhub_score":67,"alzhub_url":"https://alzhub.org/study/prevalence-of-apolipoprotein-e4-genotype-and-homozygotes-apoe-e4-4-22179327","doi":"10.1159/000334607","journal":"Neuroepidemiology","n_participants":null,"pmid":"22179327","source_url":"https://pubmed.ncbi.nlm.nih.gov/22179327/","study_design":"systematic review","title":"Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer's disease: a systematic review and meta-analysis","title_match":true,"year":2012},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-effects-in-alzheimer-s-disease-are-mediated-by-22637583","doi":"10.1093/brain/aws127","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"22637583","source_url":"https://pubmed.ncbi.nlm.nih.gov/22637583/","study_design":null,"title":"Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-\u03b2","title_match":true,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/role-of-inflammation-in-cognitive-impairment-results-of-observational-20955439","doi":"10.1111/j.1749-6632.2010.05726.x","journal":"Annals of the New York Academy of Sciences","n_participants":null,"pmid":"20955439","source_url":"https://pubmed.ncbi.nlm.nih.gov/20955439/","study_design":null,"title":"Role of inflammation in cognitive impairment: results of observational epidemiological studies and clinical trials","title_match":false,"year":2010},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/impact-of-apolipoprotein-e-apoe-polymorphism-on-brain-apoe-levels-18987181","doi":"10.1523/jneurosci.1972-08.2008","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"18987181","source_url":"https://pubmed.ncbi.nlm.nih.gov/18987181/","study_design":null,"title":"Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels","title_match":false,"year":2008},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/herpes-simplex-virus-infection-causes-cellular-beta-amyloid-17980964","doi":"10.1016/j.neulet.2007.09.077","journal":"Neuroscience letters","n_participants":null,"pmid":"17980964","source_url":"https://pubmed.ncbi.nlm.nih.gov/17980964/","study_design":null,"title":"Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation","title_match":false,"year":2007},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/altered-lipid-metabolism-in-brain-injury-and-disorders-18751914","doi":"10.1007/978-1-4020-8831-5_9","journal":"Sub-cellular biochemistry","n_participants":null,"pmid":"18751914","source_url":"https://pubmed.ncbi.nlm.nih.gov/18751914/","study_design":null,"title":"Altered lipid metabolism in brain injury and disorders","title_match":false,"year":2008},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/involvement-of-lipids-in-alzheimer-s-disease-pathology-and-potential-32581851","doi":"10.3389/fphys.2020.00598","journal":"Frontiers in physiology","n_participants":null,"pmid":"32581851","source_url":"https://pubmed.ncbi.nlm.nih.gov/32581851/","study_design":null,"title":"Involvement of Lipids in Alzheimer's Disease Pathology and Potential Therapies","title_match":false,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/carboxyl-terminal-truncated-apolipoprotein-e4-causes-alzheimer-s-12939405","doi":"10.1073/pnas.1434398100","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"12939405","source_url":"https://pubmed.ncbi.nlm.nih.gov/12939405/","study_design":null,"title":"Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice","title_match":true,"year":2003},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/atrophy-of-the-medial-occipitotemporal-inferior-and-middle-temporal-10794844","doi":"10.1016/s0197-4580(99)00107-4","journal":"Neurobiology of aging","n_participants":20,"pmid":"10794844","source_url":"https://pubmed.ncbi.nlm.nih.gov/10794844/","study_design":null,"title":"Atrophy of the medial occipitotemporal, inferior, and middle temporal gyri in non-demented elderly predict decline to Alzheimer's disease","title_match":false,"year":2000},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-from-atherosclerosis-to-alzheimer-s-disease-and-10431657","doi":"10.1097/00041433-199906000-00003","journal":"Current opinion in lipidology","n_participants":null,"pmid":"10431657","source_url":"https://pubmed.ncbi.nlm.nih.gov/10431657/","study_design":null,"title":"Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond","title_match":false,"year":1999},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-cholesterol-metabolism-diabetes-and-the-convergence-16786033","doi":"10.1038/sj.mp.4001854","journal":"Molecular psychiatry","n_participants":null,"pmid":"16786033","source_url":"https://pubmed.ncbi.nlm.nih.gov/16786033/","study_design":null,"title":"Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease","title_match":false,"year":2006},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/expression-of-human-apolipoprotein-e3-or-e4-in-the-brains-of-apoe-10366621","doi":"10.1523/jneurosci.19-12-04867.1999","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"10366621","source_url":"https://pubmed.ncbi.nlm.nih.gov/10366621/","study_design":null,"title":"Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration","title_match":false,"year":1999},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-apoe-genotype-associated-disease-risks-a-phenome-32818802","doi":"10.1016/j.ebiom.2020.102954","journal":"EBioMedicine","n_participants":null,"pmid":"32818802","source_url":"https://pubmed.ncbi.nlm.nih.gov/32818802/","study_design":null,"title":"Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank","title_match":false,"year":2020},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/alpha-synuclein-immunoreactive-cortical-lewy-bodies-are-associated-10965798","doi":"10.1007/s004019900168","journal":"Acta neuropathologica","n_participants":45,"pmid":"10965798","source_url":"https://pubmed.ncbi.nlm.nih.gov/10965798/","study_design":null,"title":"Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease","title_match":false,"year":2000},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/lipid-and-receptor-binding-regions-of-apolipoprotein-e4-fragments-act-16344479","doi":"10.1073/pnas.0508254102","journal":"Proceedings of the National Academy of Sciences of the United States of America","n_participants":null,"pmid":"16344479","source_url":"https://pubmed.ncbi.nlm.nih.gov/16344479/","study_design":null,"title":"Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity","title_match":true,"year":2005},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/clinical-and-pathological-correlates-of-apolipoprotein-e-epsilon-4-in-8572669","doi":"10.1002/ana.410390110","journal":"Annals of neurology","n_participants":null,"pmid":"8572669","source_url":"https://pubmed.ncbi.nlm.nih.gov/8572669/","study_design":"longitudinal study","title":"Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease","title_match":false,"year":1996},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-epsilon4-alleles-in-cerebral-amyloid-angiopathy-and-8669492","doi":null,"journal":"The American journal of pathology","n_participants":null,"pmid":"8669492","source_url":"https://pubmed.ncbi.nlm.nih.gov/8669492/","study_design":null,"title":"Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease","title_match":true,"year":1996},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-from-lipid-transport-to-neurobiology-20854843","doi":"10.1016/j.plipres.2010.09.001","journal":"Progress in lipid research","n_participants":null,"pmid":"20854843","source_url":"https://pubmed.ncbi.nlm.nih.gov/20854843/","study_design":null,"title":"Apolipoprotein E: from lipid transport to neurobiology","title_match":false,"year":2011},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e4-impairs-neuronal-insulin-signaling-by-trapping-28957663","doi":"10.1016/j.neuron.2017.09.003","journal":"Neuron","n_participants":null,"pmid":"28957663","source_url":"https://pubmed.ncbi.nlm.nih.gov/28957663/","study_design":null,"title":"Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes","title_match":true,"year":2017},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/menopause-impacts-human-brain-structure-connectivity-energy-34108509","doi":"10.1038/s41598-021-90084-y","journal":"Scientific reports","n_participants":null,"pmid":"34108509","source_url":"https://pubmed.ncbi.nlm.nih.gov/34108509/","study_design":null,"title":"Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition","title_match":false,"year":2021},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/reconstruction-of-the-human-blood-brain-barrier-in-vitro-reveals-a-32514169","doi":"10.1038/s41591-020-0886-4","journal":"Nature medicine","n_participants":null,"pmid":"32514169","source_url":"https://pubmed.ncbi.nlm.nih.gov/32514169/","study_design":null,"title":"Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes","title_match":true,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/sex-differences-in-cognitive-impairment-in-alzheimer-s-disease-27014598","doi":"10.5498/wjp.v6.i1.54","journal":"World journal of psychiatry","n_participants":null,"pmid":"27014598","source_url":"https://pubmed.ncbi.nlm.nih.gov/27014598/","study_design":null,"title":"Sex differences in cognitive impairment in Alzheimer's disease","title_match":false,"year":2016},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/blood-brain-barrier-associated-pericytes-internalize-and-clear-30340601","doi":"10.1186/s13024-018-0286-0","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"30340601","source_url":"https://pubmed.ncbi.nlm.nih.gov/30340601/","study_design":"post-hoc analysis","title":"Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-\u03b242 by LRP1-dependent apolipoprotein E isoform-specific mechanism","title_match":false,"year":2018},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/susceptibility-locus-for-alzheimer-s-disease-on-chromosome-10-11125144","doi":"10.1126/science.290.5500.2304","journal":"Science (New York, N.Y.)","n_participants":null,"pmid":"11125144","source_url":"https://pubmed.ncbi.nlm.nih.gov/11125144/","study_design":null,"title":"Susceptibility locus for Alzheimer's disease on chromosome 10","title_match":false,"year":2000},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/apolipoprotein-e-epsilon4-allele-ad-pathology-and-the-clinical-12552039","doi":"10.1212/01.wnl.0000042478.08543.f7","journal":"Neurology","n_participants":77,"pmid":"12552039","source_url":"https://pubmed.ncbi.nlm.nih.gov/12552039/","study_design":null,"title":"Apolipoprotein E epsilon4 allele, AD pathology, and the clinical expression of Alzheimer's disease","title_match":true,"year":2003},{"alzhub_score":66,"alzhub_url":"https://alzhub.org/study/smoking-is-associated-with-an-increased-risk-of-dementia-a-meta-25763939","doi":"10.1371/journal.pone.0118333","journal":"PloS one","n_participants":null,"pmid":"25763939","source_url":"https://pubmed.ncbi.nlm.nih.gov/25763939/","study_design":null,"title":"Smoking is associated with an increased risk of dementia: a meta-analysis of prospective cohort studies with investigation of potential effect modifiers","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/reduced-hippocampal-insulin-degrading-enzyme-in-late-onset-alzheimer-12507914","doi":"10.1016/s0002-9440(10)63822-9","journal":"The American journal of pathology","n_participants":null,"pmid":"12507914","source_url":"https://pubmed.ncbi.nlm.nih.gov/12507914/","study_design":null,"title":"Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele","title_match":true,"year":2003},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/amyloid-beta-protein-clearance-and-degradation-abcd-pathways-and-25523424","doi":"10.2174/1567205012666141218140953","journal":"Current Alzheimer research","n_participants":null,"pmid":"25523424","source_url":"https://pubmed.ncbi.nlm.nih.gov/25523424/","study_design":null,"title":"Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/myeloperoxidase-polymorphism-is-associated-with-gender-specific-risk-9918702","doi":"10.1006/exnr.1998.6977","journal":"Experimental neurology","n_participants":null,"pmid":"9918702","source_url":"https://pubmed.ncbi.nlm.nih.gov/9918702/","study_design":null,"title":"Myeloperoxidase polymorphism is associated with gender specific risk for Alzheimer's disease","title_match":false,"year":1999},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/human-and-murine-apoe-markedly-alters-a-beta-metabolism-before-and-11950276","doi":"10.1006/nbdi.2002.0483","journal":"Neurobiology of disease","n_participants":null,"pmid":"11950276","source_url":"https://pubmed.ncbi.nlm.nih.gov/11950276/","study_design":null,"title":"Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease","title_match":false,"year":2002},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/an-effector-reduced-anti-amyloid-a-antibody-with-unique-a-binding-22787053","doi":"10.1523/jneurosci.4742-11.2012","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"22787053","source_url":"https://pubmed.ncbi.nlm.nih.gov/22787053/","study_design":null,"title":"An effector-reduced anti-\u03b2-amyloid (A\u03b2) antibody with unique a\u03b2 binding properties promotes neuroprotection and glial engulfment of A\u03b2","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/imaging-the-default-mode-network-in-aging-and-dementia-21807094","doi":"10.1016/j.bbadis.2011.07.008","journal":"Biochimica et biophysica acta","n_participants":null,"pmid":"21807094","source_url":"https://pubmed.ncbi.nlm.nih.gov/21807094/","study_design":null,"title":"Imaging the default mode network in aging and dementia","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/gabaergic-interneuron-dysfunction-impairs-hippocampal-neurogenesis-in-19951691","doi":"10.1016/j.stem.2009.10.015","journal":"Cell stem cell","n_participants":null,"pmid":"19951691","source_url":"https://pubmed.ncbi.nlm.nih.gov/19951691/","study_design":null,"title":"GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice","title_match":true,"year":2009},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/plastic-neuronal-remodeling-is-impaired-in-patients-with-alzheimer-s-8987775","doi":"10.1523/jneurosci.17-02-00516.1997","journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","n_participants":null,"pmid":"8987775","source_url":"https://pubmed.ncbi.nlm.nih.gov/8987775/","study_design":null,"title":"Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein epsilon 4 allele","title_match":false,"year":1997},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/the-role-of-cholesterol-in-the-biosynthesis-of-beta-amyloid-10501560","doi":"10.1097/00001756-199906030-00014","journal":"Neuroreport","n_participants":null,"pmid":"10501560","source_url":"https://pubmed.ncbi.nlm.nih.gov/10501560/","study_design":null,"title":"The role of cholesterol in the biosynthesis of beta-amyloid","title_match":false,"year":1999},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/monoaminergic-neuropathology-in-alzheimer-s-disease-27084356","doi":"10.1016/j.pneurobio.2016.04.001","journal":"Progress in neurobiology","n_participants":null,"pmid":"27084356","source_url":"https://pubmed.ncbi.nlm.nih.gov/27084356/","study_design":null,"title":"Monoaminergic neuropathology in Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-default-mode-network-in-healthy-aging-and-alzheimer-s-disease-21760988","doi":"10.4061/2011/535816","journal":"International journal of Alzheimer's disease","n_participants":null,"pmid":"21760988","source_url":"https://pubmed.ncbi.nlm.nih.gov/21760988/","study_design":null,"title":"The default mode network in healthy aging and Alzheimer's disease","title_match":false,"year":2011},{"alzhub_score":69,"alzhub_url":"https://alzhub.org/study/dissecting-the-genetic-relationship-between-cardiovascular-risk-30413934","doi":"10.1007/s00401-018-1928-6","journal":"Acta neuropathologica","n_participants":null,"pmid":"30413934","source_url":"https://pubmed.ncbi.nlm.nih.gov/30413934/","study_design":"meta-analysis","title":"Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease","title_match":false,"year":2019},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/snps-associated-with-cerebrospinal-fluid-phospho-tau-levels-influence-20862329","doi":"10.1371/journal.pgen.1001101","journal":"PLoS genetics","n_participants":null,"pmid":"20862329","source_url":"https://pubmed.ncbi.nlm.nih.gov/20862329/","study_design":"case-control study","title":"SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/25-hydroxycholesterol-amplifies-microglial-il-1-production-in-an-apoe-32552741","doi":"10.1186/s12974-020-01869-3","journal":"Journal of neuroinflammation","n_participants":null,"pmid":"32552741","source_url":"https://pubmed.ncbi.nlm.nih.gov/32552741/","study_design":null,"title":"25-Hydroxycholesterol amplifies microglial IL-1\u03b2 production in an apoE isoform-dependent manner","title_match":false,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/genome-wide-scan-of-copy-number-variation-in-late-onset-alzheimer-s-20061627","doi":"10.3233/jad-2010-1212","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"20061627","source_url":"https://pubmed.ncbi.nlm.nih.gov/20061627/","study_design":null,"title":"Genome-wide scan of copy number variation in late-onset Alzheimer's disease","title_match":false,"year":2010},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/complement-receptor-1-cr1-and-alzheimer-s-disease-21840620","doi":"10.1016/j.imbio.2011.07.017","journal":"Immunobiology","n_participants":null,"pmid":"21840620","source_url":"https://pubmed.ncbi.nlm.nih.gov/21840620/","study_design":null,"title":"Complement receptor 1 (CR1) and Alzheimer's disease","title_match":false,"year":2012},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/genetic-markers-for-diagnosis-and-pathogenesis-of-alzheimer-s-disease-24838203","doi":"10.1016/j.gene.2014.05.031","journal":"Gene","n_participants":null,"pmid":"24838203","source_url":"https://pubmed.ncbi.nlm.nih.gov/24838203/","study_design":null,"title":"Genetic markers for diagnosis and pathogenesis of Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":62,"alzhub_url":"https://alzhub.org/study/systemic-inflammation-as-a-predictor-of-brain-aging-contributions-of-29357308","doi":"10.1016/j.neuroimage.2017.12.027","journal":"NeuroImage","n_participants":226,"pmid":"29357308","source_url":"https://pubmed.ncbi.nlm.nih.gov/29357308/","study_design":"longitudinal study","title":"Systemic inflammation as a predictor of brain aging: Contributions of physical activity, metabolic risk, and genetic risk","title_match":false,"year":2018},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/a-22-single-nucleotide-polymorphism-alzheimer-s-disease-risk-score-26086184","doi":"10.1016/j.jalz.2015.02.013","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"26086184","source_url":"https://pubmed.ncbi.nlm.nih.gov/26086184/","study_design":null,"title":"A 22-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid A\u03b242","title_match":false,"year":2015},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/alzheimer-s-disease-genes-and-cognition-in-the-nondemented-general-22592056","doi":"10.1016/j.biopsych.2012.04.009","journal":"Biological psychiatry","n_participants":null,"pmid":"22592056","source_url":"https://pubmed.ncbi.nlm.nih.gov/22592056/","study_design":null,"title":"Alzheimer's disease genes and cognition in the nondemented general population","title_match":false,"year":2013},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/mild-traumatic-brain-injury-is-associated-with-reduced-cortical-28077398","doi":"10.1093/brain/aww344","journal":"Brain : a journal of neurology","n_participants":null,"pmid":"28077398","source_url":"https://pubmed.ncbi.nlm.nih.gov/28077398/","study_design":"cross-sectional","title":"Mild traumatic brain injury is associated with reduced cortical thickness in those at risk for Alzheimer's disease","title_match":false,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-genetics-of-dementia-with-lewy-bodies-current-understanding-and-30097731","doi":"10.1007/s11910-018-0874-y","journal":"Current neurology and neuroscience reports","n_participants":null,"pmid":"30097731","source_url":"https://pubmed.ncbi.nlm.nih.gov/30097731/","study_design":null,"title":"The Genetics of Dementia with Lewy Bodies: Current Understanding and Future Directions","title_match":false,"year":2018},{"alzhub_score":76,"alzhub_url":"https://alzhub.org/study/whole-exome-sequencing-and-imaging-genetics-identify-functional-23608917","doi":"10.1038/mp.2013.24","journal":"Molecular psychiatry","n_participants":315,"pmid":"23608917","source_url":"https://pubmed.ncbi.nlm.nih.gov/23608917/","study_design":"meta-analysis","title":"Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment","title_match":false,"year":2013},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-tau-levels-are-associated-with-abnormal-neuronal-35346299","doi":"10.1186/s13024-022-00521-3","journal":"Molecular neurodegeneration","n_participants":1380,"pmid":"35346299","source_url":"https://pubmed.ncbi.nlm.nih.gov/35346299/","study_design":null,"title":"Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/gba-and-apoe-4-associate-with-sporadic-dementia-with-lewy-bodies-in-31065058","doi":"10.1038/s41598-019-43458-2","journal":"Scientific reports","n_participants":19,"pmid":"31065058","source_url":"https://pubmed.ncbi.nlm.nih.gov/31065058/","study_design":null,"title":"GBA and APOE \u03b54 associate with sporadic dementia with Lewy bodies in European genome wide association study","title_match":true,"year":2019},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/genome-wide-association-reveals-genetic-effects-on-human-a42-and-20932310","doi":"10.1186/1471-2377-10-90","journal":"BMC neurology","n_participants":410,"pmid":"20932310","source_url":"https://pubmed.ncbi.nlm.nih.gov/20932310/","study_design":null,"title":"Genome-wide association reveals genetic effects on human A\u03b242 and \u03c4 protein levels in cerebrospinal fluids: a case control study","title_match":false,"year":2010},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/apoe-variant-p-v236e-is-associated-with-markedly-reduced-risk-of-24607147","doi":"10.1186/1750-1326-9-11","journal":"Molecular neurodegeneration","n_participants":9114,"pmid":"24607147","source_url":"https://pubmed.ncbi.nlm.nih.gov/24607147/","study_design":null,"title":"ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/intracellular-clusterin-interacts-with-brain-isoforms-of-the-bridging-25051234","doi":"10.1371/journal.pone.0103187","journal":"PloS one","n_participants":null,"pmid":"25051234","source_url":"https://pubmed.ncbi.nlm.nih.gov/25051234/","study_design":null,"title":"Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease","title_match":false,"year":2014},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/a-locus-at-19q13-31-significantly-reduces-the-apoe-4-risk-for-35788729","doi":"10.1371/journal.pgen.1009977","journal":"PLoS genetics","n_participants":null,"pmid":"35788729","source_url":"https://pubmed.ncbi.nlm.nih.gov/35788729/","study_design":null,"title":"A locus at 19q13.31 significantly reduces the ApoE \u03b54 risk for Alzheimer's Disease in African Ancestry","title_match":true,"year":2022},{"alzhub_score":59,"alzhub_url":"https://alzhub.org/study/apoe4-exacerbates-synuclein-seeding-activity-and-contributes-to-35471463","doi":"10.1007/s00401-022-02421-8","journal":"Acta neuropathologica","n_participants":469,"pmid":"35471463","source_url":"https://pubmed.ncbi.nlm.nih.gov/35471463/","study_design":null,"title":"APOE4 exacerbates \u03b1-synuclein seeding activity and contributes to neurotoxicity in Alzheimer's disease with Lewy body pathology","title_match":true,"year":2022},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/a-comprehensive-analysis-of-methods-for-assessing-polygenic-burden-on-32226939","doi":"10.1093/braincomms/fcz047","journal":"Brain communications","n_participants":null,"pmid":"32226939","source_url":"https://pubmed.ncbi.nlm.nih.gov/32226939/","study_design":"cross-sectional","title":"A comprehensive analysis of methods for assessing polygenic burden on Alzheimer's disease pathology and risk beyond APOE","title_match":false,"year":2020},{"alzhub_score":72,"alzhub_url":"https://alzhub.org/study/replication-of-epha1-and-cd33-associations-with-late-onset-alzheimer-21798052","doi":"10.1186/1750-1326-6-54","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"21798052","source_url":"https://pubmed.ncbi.nlm.nih.gov/21798052/","study_design":"meta-analysis","title":"Replication of EPHA1 and CD33 associations with late-onset Alzheimer's disease: a multi-centre case-control study","title_match":false,"year":2011},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/polygenic-risk-scores-in-familial-alzheimer-disease-28213371","doi":"10.1212/wnl.0000000000003734","journal":"Neurology","n_participants":null,"pmid":"28213371","source_url":"https://pubmed.ncbi.nlm.nih.gov/28213371/","study_design":null,"title":"Polygenic risk scores in familial Alzheimer disease","title_match":false,"year":2017},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/polymorphisms-of-cr1-clu-and-picalm-confer-susceptibility-of-22015308","doi":"10.1016/j.neurobiolaging.2011.09.016","journal":"Neurobiology of aging","n_participants":null,"pmid":"22015308","source_url":"https://pubmed.ncbi.nlm.nih.gov/22015308/","study_design":null,"title":"Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population","title_match":false,"year":2012},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/genetic-evaluation-of-dementia-with-lewy-bodies-implicates-distinct-35381062","doi":"10.1093/brain/awab402","journal":"Brain : a journal of neurology","n_participants":88,"pmid":"35381062","source_url":"https://pubmed.ncbi.nlm.nih.gov/35381062/","study_design":null,"title":"Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups","title_match":false,"year":2022},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/alzheimer-disease-scientific-breakthroughs-and-translational-28578785","doi":"10.1016/j.mayocp.2017.02.011","journal":"Mayo Clinic proceedings","n_participants":null,"pmid":"28578785","source_url":"https://pubmed.ncbi.nlm.nih.gov/28578785/","study_design":null,"title":"Alzheimer Disease: Scientific Breakthroughs and Translational Challenges","title_match":false,"year":2017},{"alzhub_score":41,"alzhub_url":"https://alzhub.org/study/the-contribution-of-genetic-factors-to-cognitive-impairment-and-30866553","doi":"10.3390/ijms20051177","journal":"International journal of molecular sciences","n_participants":null,"pmid":"30866553","source_url":"https://pubmed.ncbi.nlm.nih.gov/30866553/","study_design":null,"title":"The Contribution of Genetic Factors to Cognitive Impairment and Dementia: Apolipoprotein E Gene, Gene Interactions, and Polygenic Risk","title_match":false,"year":2019},{"alzhub_score":74,"alzhub_url":"https://alzhub.org/study/genome-wide-association-identifies-the-first-risk-loci-for-psychosis-34112972","doi":"10.1038/s41380-021-01152-8","journal":"Molecular psychiatry","n_participants":null,"pmid":"34112972","source_url":"https://pubmed.ncbi.nlm.nih.gov/34112972/","study_design":"meta-analysis","title":"Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease","title_match":false,"year":2021},{"alzhub_score":38,"alzhub_url":"https://alzhub.org/study/higher-peripheral-trem2-mrna-levels-relate-to-cognitive-deficits-and-28453482","doi":"10.3233/jad-161277","journal":"Journal of Alzheimer's disease : JAD","n_participants":null,"pmid":"28453482","source_url":"https://pubmed.ncbi.nlm.nih.gov/28453482/","study_design":null,"title":"Higher Peripheral TREM2 mRNA Levels Relate to Cognitive Deficits and Hippocampal Atrophy in Alzheimer's Disease and Amnestic Mild Cognitive Impairment","title_match":false,"year":2017},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/effect-of-i-apoe-i-alleles-on-the-glial-transcriptome-in-normal-aging-36199750","doi":"10.1038/s43587-021-00123-6","journal":"Nature aging","n_participants":null,"pmid":"36199750","source_url":"https://pubmed.ncbi.nlm.nih.gov/36199750/","study_design":null,"title":"Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer's disease","title_match":false,"year":2021},{"alzhub_score":57,"alzhub_url":"https://alzhub.org/study/the-apoe-4-exerts-differential-effects-on-familial-and-other-subtypes-32881347","doi":"10.1002/alz.12153","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":119,"pmid":"32881347","source_url":"https://pubmed.ncbi.nlm.nih.gov/32881347/","study_design":null,"title":"The APOE \u03b54 exerts differential effects on familial and other subtypes of Alzheimer's disease","title_match":true,"year":2020},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/isoform-specific-effects-of-apolipoprotein-e-on-markers-of-34071762","doi":"10.3390/cimb43010018","journal":"Current issues in molecular biology","n_participants":null,"pmid":"34071762","source_url":"https://pubmed.ncbi.nlm.nih.gov/34071762/","study_design":null,"title":"Isoform-Specific Effects of Apolipoprotein E on Markers of Inflammation and Toxicity in Brain Glia and Neuronal Cells In Vitro","title_match":false,"year":2021},{"alzhub_score":53,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-strem2-in-alzheimer-s-disease-comparisons-between-32985583","doi":"10.1038/s41598-020-72878-8","journal":"Scientific reports","n_participants":299,"pmid":"32985583","source_url":"https://pubmed.ncbi.nlm.nih.gov/32985583/","study_design":null,"title":"Cerebrospinal fluid sTREM2 in Alzheimer's disease: comparisons between clinical presentation and AT classification","title_match":false,"year":2020},{"alzhub_score":46,"alzhub_url":"https://alzhub.org/study/association-of-apoe-with-primary-open-angle-glaucoma-suggests-a-32614373","doi":"10.1167/iovs.61.8.3","journal":"Investigative ophthalmology & visual science","n_participants":null,"pmid":"32614373","source_url":"https://pubmed.ncbi.nlm.nih.gov/32614373/","study_design":null,"title":"Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE \u03b54","title_match":true,"year":2020},{"alzhub_score":36,"alzhub_url":"https://alzhub.org/study/from-common-to-rare-variants-the-genetic-component-of-alzheimer-28002825","doi":"10.1159/000452256","journal":"Human heredity","n_participants":null,"pmid":"28002825","source_url":"https://pubmed.ncbi.nlm.nih.gov/28002825/","study_design":null,"title":"From Common to Rare Variants: The Genetic Component of Alzheimer Disease","title_match":false,"year":2016},{"alzhub_score":48,"alzhub_url":"https://alzhub.org/study/characterizing-molecular-and-synaptic-signatures-in-mouse-models-of-38735056","doi":"10.1002/alz.13828","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","n_participants":null,"pmid":"38735056","source_url":"https://pubmed.ncbi.nlm.nih.gov/38735056/","study_design":null,"title":"Characterizing molecular and synaptic signatures in mouse models of late-onset Alzheimer's disease independent of amyloid and tau pathology","title_match":false,"year":2024},{"alzhub_score":43,"alzhub_url":"https://alzhub.org/study/genetic-phenotypes-of-alzheimer-s-disease-mechanisms-and-potential-37589021","doi":"10.1007/s43657-023-00098-x","journal":"Phenomics (Cham, Switzerland)","n_participants":null,"pmid":"37589021","source_url":"https://pubmed.ncbi.nlm.nih.gov/37589021/","study_design":null,"title":"Genetic Phenotypes of Alzheimer's Disease: Mechanisms and Potential Therapy","title_match":false,"year":2023},{"alzhub_score":47,"alzhub_url":"https://alzhub.org/study/the-alzheimer-s-cell-atlas-taca-a-single-cell-molecular-map-for-36254161","doi":"10.1002/trc2.12350","journal":"Alzheimer's & dementia (New York, N. Y.)","n_participants":null,"pmid":"36254161","source_url":"https://pubmed.ncbi.nlm.nih.gov/36254161/","study_design":null,"title":"The Alzheimer's Cell Atlas (TACA): A single-cell molecular map for translational therapeutics accelerator in Alzheimer's disease","title_match":false,"year":2022},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/the-alzheimer-s-disease-associated-r47h-variant-of-trem2-has-an-28149270","doi":"10.3389/fnins.2016.00618","journal":"Frontiers in neuroscience","n_participants":null,"pmid":"28149270","source_url":"https://pubmed.ncbi.nlm.nih.gov/28149270/","study_design":null,"title":"The Alzheimer's Disease-Associated R47H Variant of TREM2 Has an Altered Glycosylation Pattern and Protein Stability","title_match":false,"year":2016},{"alzhub_score":50,"alzhub_url":"https://alzhub.org/study/association-study-of-trem2-polymorphism-rs75932628-with-late-onset-24725293","doi":"10.1179/1743132814y.0000000376","journal":"Neurological research","n_participants":null,"pmid":"24725293","source_url":"https://pubmed.ncbi.nlm.nih.gov/24725293/","study_design":"case-control study","title":"Association study of TREM2 polymorphism rs75932628 with late-onset Alzheimer's disease in Chinese Han population","title_match":false,"year":2014},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/biophysical-mapping-of-trem2-ligand-interactions-reveals-shared-39789647","doi":"10.1186/s13024-024-00795-9","journal":"Molecular neurodegeneration","n_participants":null,"pmid":"39789647","source_url":"https://pubmed.ncbi.nlm.nih.gov/39789647/","study_design":null,"title":"Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands","title_match":false,"year":2025},{"alzhub_score":55,"alzhub_url":"https://alzhub.org/study/cerebrospinal-fluid-biomarkers-of-alzheimer-s-disease-in-a-cohort-of-32671183","doi":"10.1002/dad2.12057","journal":"Alzheimer's & dementia (Amsterdam, Netherlands)","n_participants":44,"pmid":"32671183","source_url":"https://pubmed.ncbi.nlm.nih.gov/32671183/","study_design":null,"title":"Cerebrospinal fluid biomarkers of Alzheimer's disease in a cohort of adults with Down syndrome","title_match":false,"year":2020},{"alzhub_score":52,"alzhub_url":"https://alzhub.org/study/genome-sequencing-for-early-onset-or-atypical-dementia-high-31836585","doi":"10.1101/mcs.a003491","journal":"Cold Spring Harbor molecular case studies","n_participants":32,"pmid":"31836585","source_url":"https://pubmed.ncbi.nlm.nih.gov/31836585/","study_design":null,"title":"Genome sequencing for early-onset or atypical dementia: high diagnostic yield and frequent observation of multiple contributory alleles","title_match":false,"year":2019},{"alzhub_score":40,"alzhub_url":"https://alzhub.org/study/misframed-ubiquitin-and-impaired-protein-quality-control-an-early-26388726","doi":"10.3389/fnmol.2015.00047","journal":"Frontiers in molecular neuroscience","n_participants":null,"pmid":"26388726","source_url":"https://pubmed.ncbi.nlm.nih.gov/26388726/","study_design":null,"title":"Misframed ubiquitin and impaired protein quality control: an early event in Alzheimer's disease","title_match":false,"year":2015},{"alzhub_score":45,"alzhub_url":"https://alzhub.org/study/microglia-gravitate-toward-amyloid-plaques-surrounded-by-externalized-38981007","doi":"10.1002/advs.202400064","journal":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","n_participants":null,"pmid":"38981007","source_url":"https://pubmed.ncbi.nlm.nih.gov/38981007/","study_design":null,"title":"Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2","title_match":false,"year":2024}]}